Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionO-acyltransferase activity

CRAT CASD1 DGAT2L6

3.14e-0559213GO:0008374
GeneOntologyMolecularFunctionO-acetyltransferase activity

CRAT CASD1

3.78e-059212GO:0016413
GeneOntologyMolecularFunctionacyltransferase activity

TRIM27 CRAT TRIM21 CASD1 DGAT2L6

1.05e-03775215GO:0016746
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

CRAT CASD1 DGAT2L6

1.90e-03238213GO:0016747
GeneOntologyMolecularFunctionacetyltransferase activity

CRAT CASD1

5.29e-03104212GO:0016407
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A13 SLC7A5

5.39e-03105212GO:0015171
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP15 USP4

6.32e-03114212GO:0004843
GeneOntologyMolecularFunctiondeubiquitinase activity

USP15 USP4

7.44e-03124212GO:0101005
GeneOntologyMolecularFunctionubiquitin-like protein peptidase activity

USP15 USP4

9.01e-03137212GO:0019783
GeneOntologyMolecularFunctionzinc ion binding

TRIM27 SLU7 TRIM21 ZMYM4

1.28e-02891214GO:0008270
DomainUb_USP-typ

USP15 USP4

7.21e-064212IPR028135
DomainZnf_B-box_chordata

TRIM27 TRIM21

7.21e-064212IPR020457
DomainUbiquitin_3

USP15 USP4

7.21e-064212PF14836
DomainDUSP

USP15 USP4

1.80e-056212PF06337
DomainDUSP

USP15 USP4

1.80e-056212SM00695
Domain-

USP15 USP4

2.52e-0572123.30.2230.10
DomainPept_C19_DUSP

USP15 USP4

2.52e-057212IPR006615
DomainDUSP

USP15 USP4

2.52e-057212PS51283
DomainPRY

TRIM27 TRIM21

1.01e-0342212PF13765
DomainPRY

TRIM27 TRIM21

1.32e-0348212SM00589
DomainPRY

TRIM27 TRIM21

1.32e-0348212IPR006574
DomainUSP_CS

USP15 USP4

2.47e-0366212IPR018200
DomainBBOX

TRIM27 TRIM21

2.70e-0369212SM00336
DomainButyrophylin

TRIM27 TRIM21

2.78e-0370212IPR003879
DomainUSP_1

USP15 USP4

2.78e-0370212PS00972
DomainUCH

USP15 USP4

2.86e-0371212PF00443
Domain-

TRIM27 TRIM21

2.86e-03712124.10.45.10
DomainUSP_2

USP15 USP4

2.86e-0371212PS00973
DomainUSP_dom

USP15 USP4

2.94e-0372212IPR028889
Domainzf-B_box

TRIM27 TRIM21

2.94e-0372212PF00643
DomainPeptidase_C19_UCH

USP15 USP4

2.94e-0372212IPR001394
DomainUSP_3

USP15 USP4

2.94e-0372212PS50235
DomainZF_BBOX

TRIM27 TRIM21

3.61e-0380212PS50119
DomainZnf_B-box

TRIM27 TRIM21

3.70e-0381212IPR000315
DomainSPRY

TRIM27 TRIM21

4.25e-0387212SM00449
DomainSPRY

TRIM27 TRIM21

4.95e-0394212PF00622
DomainSPRY_dom

TRIM27 TRIM21

4.95e-0394212IPR003877
DomainB30.2/SPRY

TRIM27 TRIM21

5.05e-0395212IPR001870
DomainB302_SPRY

TRIM27 TRIM21

5.05e-0395212PS50188
DomainTPR

TTC8 TTC39A

9.12e-03129212SM00028
DomainTPR_repeat

TTC8 TTC39A

9.67e-03133212IPR019734
DomainZnf_RING_CS

TRIM27 TRIM21

1.43e-02163212IPR017907
DomainTPR

TTC8 TTC39A

1.46e-02165212PS50005
DomainTPR_REGION

TTC8 TTC39A

1.46e-02165212PS50293
DomainZnf_C3HC4_RING-type

TRIM27 TRIM21

1.58e-02172212IPR018957
Domain-

TTC8 TTC39A

2.24e-022072121.25.40.10
Pubmed

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

TRIM27 USP15 USP4 TRIM21

5.72e-086321423105109
Pubmed

Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.

USP4 TRIM21

3.47e-07221216316627
Pubmed

Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function.

USP4 TRIM21

3.47e-07221211461834
Pubmed

Structural variability of the ubiquitin specific protease DUSP-UBL double domains.

USP15 USP4

1.04e-06321222001210
Pubmed

Phosphorylation of USP15 and USP4 Regulates Localization and Spliceosomal Deubiquitination.

USP15 USP4

1.04e-06321231330151
Pubmed

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.

USP15 USP4

1.04e-06321226503449
Pubmed

Function and subcellular location of Ro52beta.

USP4 TRIM21

1.04e-06321216403452
Pubmed

Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3.

USP15 USP4

2.08e-06421227060135
Pubmed

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31.

USP15 USP4

5.20e-06621228088760
Pubmed

Unique features of TRIM5alpha among closely related human TRIM family members.

TRIM27 TRIM21

7.28e-06721217156811
Pubmed

UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself.

USP4 TRIM21

7.28e-06721216472766
Pubmed

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.

USP15 USP4

9.70e-06821222706160
Pubmed

USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

USP15 USP4

9.70e-06821226455393
Pubmed

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

TRIM27 TRIM21

1.25e-05921222829933
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP15 USP4 TRIM21 CNKSR2 ZMYM4 TAF1A

2.15e-05100521619615732
Pubmed

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling.

SLC7A5 PMEL

2.70e-051321220374249
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP15 USP4

3.63e-05152129827704
Pubmed

A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

GPD2 USP4

4.15e-051621225082827
Pubmed

Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.

USP15 USP4

4.70e-051721229299163
Pubmed

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

TRIM27 TRIM21

5.28e-051821223077300
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

SLC6A13 GABBR1

5.28e-051821218985723
Pubmed

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

TRIM27 TRIM21

7.24e-052121218248090
Pubmed

Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.

USP15 SLU7 USP4

7.55e-0513721337039823
Pubmed

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

TRIM27 TRIM21

7.96e-052221224981174
Pubmed

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

USP15 USP4

1.30e-042821222118674
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

KIF1A USP15 SLC7A5 USP4

1.79e-0448121428190767
Pubmed

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.

USP15 USP4

1.81e-043321230323974
Pubmed

An atlas of genetic influences on human blood metabolites.

CRAT SLC6A13 SLC7A5

1.99e-0419021324816252
Pubmed

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.

USP15 USP4

2.04e-043521233378683
Pubmed

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.

USP15 USP4

2.16e-043621222626734
Pubmed

The tripartite motif family identifies cell compartments.

TRIM27 TRIM21

2.81e-044121211331580
Pubmed

The in vivo brain interactome of the amyloid precursor protein.

KIF1A GABBR1

4.18e-045021217934213
CytobandEnsembl 112 genes in cytogenetic band chr6p22

TRIM27 GABBR1

1.28e-02378212chr6p22
GeneFamilyUbiquitin specific peptidases

USP15 USP4

9.64e-0456152366
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM27 TRIM21

2.74e-039515259
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

TTC8 TTC39A

3.99e-03115152769
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

KIF1A CNKSR2

1.23e-02206152682
GeneFamilyRing finger proteins

TRIM27 TRIM21

2.12e-0227515258
ToppCell390C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRIM21 TAF1A PMEL SULT1E1

7.17e-07152214ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell390C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TRIM21 TAF1A PMEL SULT1E1

7.17e-071522144a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells-RBC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF1A USP15 SLC7A5 TTC39A

1.44e-06181214a16079b1c832456b974d9d06dd1a3eda63ac1bce
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Red_blood_cells|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF1A USP15 SLC7A5 TTC39A

1.44e-06181214fe2f8b4bd8b09be8ba933529a16e1dca08740dab
ToppCelldroplet-Lung-nan-3m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1A TTC8 TTC39A

4.81e-0515221377b319f594d5e4df29034bbf69c7490076f89dd3
ToppCellHealthy_Control-Lymphoid-pDC-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SLC7A5 TTC39A GABBR1

6.59e-05169213338ce99897cb522b86edd603f75bc15ec4dfcda3
ToppCellHealthy_Control-Lymphoid-pDC|Healthy_Control / Condition, Lineage, Cell class and cell subclass

SLC7A5 TTC39A GABBR1

6.59e-05169213a4e9b8b2f0338203455ba941b8f99bf4884d26f0
ToppCelldroplet-Bladder-nan-24m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A13 TRIM21 SULT1E1

7.81e-05179213dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1|TCGA-Adrenal / Sample_Type by Project: Shred V9

KIF1A GPD2 CNKSR2

7.81e-05179213431e1b29015ec817f778499106d24b19cfc825ae
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTC8 CNKSR2 SULT1E1

7.94e-051802139b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTC8 CNKSR2 SULT1E1

7.94e-0518021308ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDR1 CNKSR2 DGAT2L6

7.94e-05180213f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TTC8 CNKSR2 SULT1E1

8.07e-051812139e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KIF1A SLC6A13 SULT1E1

8.89e-05187213fa8f221b4c2df61eadaa9c77e4cf45848b00330b
Drugmonastrol; Down 200; 100uM; PC3; HG-U133A

USP15 SLC6A13 ZMYM4 CASD1 PMEL

8.81e-07199215668_DN
DrugKF 1492

GPD2 CRAT

1.21e-056212CID000127825
Drugbis(tri-n-hexylsiloxy) silicon phthalocyanine

PMEL SULT1E1

2.26e-058212CID000163602
Drug2-naphthyl laurate

GPD2 CRAT

2.26e-058212CID000080656
Drugvalinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A

KIF1A GPD2 CNKSR2 SULT1E1

2.84e-051962145962_DN
Drugisopropyldiiodothyronine

GPD2 CRAT

2.91e-059212CID000151510
Druggb1a

GABBR1 PMEL

2.91e-059212CID000467746
Drugthyropropic acid

GPD2 CRAT

2.91e-059212CID000005804
Drugtibric acid

GPD2 CRAT

2.91e-059212CID000032335
Drugnopol

GPD2 CRAT

7.32e-0514212CID000031408
Diseasecomplement factor H-related protein 4 measurement

KIF1A CNKSR2

4.54e-0449192EFO_0600091
DiseaseAbnormality of refraction

GPD2 TTC8 SLC6A13 CNKSR2

7.91e-04673194HP_0000539
Diseaseserum metabolite measurement

GPD2 CRAT SLC6A13 SLC7A5

2.76e-03945194EFO_0005653
Diseaseunipolar depression, mood disorder

USP4 GABBR1

3.33e-03134192EFO_0003761, EFO_0004247
Diseaserefractive error, age at onset, Myopia

GPD2 TTC8

6.76e-03193192EFO_0004847, HP_0000545, MONDO_0004892
DiseaseDiabetes Mellitus, Non-Insulin-Dependent

GPD2 CNKSR2

8.78e-03221192C0011860

Protein segments in the cluster

PeptideGeneStartEntry
NWLSEWWLKTAYLQY

CRAT

96

P43155
GGYWKTWIFWKTWIF

CDR1

176

P51861
KWWQLPYYWVGIKLY

GPD2

166

P43304
KKYVWFLIGWYADNW

GABBR1

386

Q9UBS5
VYFFGVWWKNKPKWL

SLC7A5

471

Q01650
CFELKGNVYEWWFRW

CASD1

586

Q96PB1
AWVRNWTLWKYFRNY

DGAT2L6

71

Q6ZPD8
LALWAFRKWKWYQFT

KIF1A

706

Q12756
FWAVSLWYGKEYWAL

TRIM27

406

P14373
KNWWPGFHFSYFWAK

TAF1A

376

Q15573
KRSFVYVWKTWGQYW

PMEL

146

P40967
WKKYWFVLKDASLYW

CNKSR2

591

Q8WXI2
WFKQWKKYVGFDSWD

USP4

41

Q13107
WWWKVQIGKCYYRLG

TTC8

251

Q8TAM2
VPYGSWYKHVKSWWE

SULT1E1

166

P49888
NKKYTYPWWGDALGW

SLC6A13

521

Q9NSD5
RWFKQWKKYVGFDSW

USP15

36

Q9Y4E8
IWGSYWKEGRWGYKC

SLU7

431

O95391
GFWTIWLWNKQKYEA

TRIM21

376

P19474
YWELMWCFTYKGQWK

TTC39A

356

Q5SRH9
KYMYGVNAWKNWVQW

ZMYM4

1206

Q5VZL5