Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentchromosome passenger complex

AURKA AURKC AURKB

9.32e-0661643GO:0032133
DomainAur

AURKA AURKC AURKB

6.53e-0731633IPR030616
Pubmed

Differential Selective Pressures Experienced by the Aurora Kinase Gene Family.

AURKA AURKC AURKB

1.09e-073167329283376
Pubmed

Gene expression of Aurora kinases in prostate cancer and nodular hyperplasia tissues.

AURKA AURKC AURKB

1.09e-073167323075505
Pubmed

Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.

AURKA AURKC AURKB

1.09e-073167334636397
Pubmed

Deregulation of Aurora kinase gene expression in human testicular germ cell tumours.

AURKA AURKC AURKB

1.09e-073167320629650
Pubmed

SAR156497, an exquisitely selective inhibitor of aurora kinases.

AURKA AURKC AURKB

1.09e-073167325369539
Pubmed

Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.

AURKA AURKC AURKB

1.09e-073167328359584
Pubmed

Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases.

AURKA AURKC AURKB

1.09e-073167318353803
Pubmed

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.

AURKA AURKC AURKB

1.09e-073167332452402
Pubmed

Genetic Interactions between the Aurora Kinases Reveal New Requirements for AURKB and AURKC during Oocyte Meiosis.

AURKA AURKC AURKB

1.09e-073167330415701
Pubmed

Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development.

AURKA AURKC AURKB

1.09e-073167331521144
Pubmed

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.

AURKA AURKC AURKB

1.09e-073167319649632
Pubmed

Stabilization of AURKA by the E3 ubiquitin ligase CBLC in lung adenocarcinoma.

CBLC AURKA AURKB

1.09e-073167335149839
Pubmed

The aurora kinases in cell cycle and leukemia.

AURKA AURKC AURKB

1.09e-073167324632603
Pubmed

Aurora A, centrosome structure, and the centrosome cycle.

AURKA AURKC AURKB

1.09e-073167319774610
Pubmed

Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development.

AURKA AURKC AURKB

1.09e-073167312434334
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

DSC3 CFTR MTMR1 FGFRL1 SIRPA RALGAPA2 FMNL2 SLC4A2 SLC12A2 PROM2 ANO6 SIGLEC6 PLEKHA7 ARHGAP21 EPB41

1.20e-075691671530639242
Pubmed

Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.

SLC4A3 SLC4A2 SLC12A2

5.98e-068167326110920
Pubmed

Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.

AURKA AURKC AURKB

5.98e-068167314602875
Pubmed

Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.

DDB1 DDB2 JARID2

8.94e-069167328035050
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

FRYL FMNL2 DDB1 DDB2 OTUD4 ACIN1 RPL3

1.11e-05156167722952844
Pubmed

A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype.

INHBB NDST4 HEATR5A HEG1

1.66e-0532167430926747
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

MBTD1 ZC3H13 GEMIN5 FRYL MSH5 GPATCH8 NEMP2 AURKA COL18A1 TSR1 OTUD4 ACIN1 NUP188 PLEKHA7 ARHGAP21 UTP14C BRWD1

2.02e-0510841671711544199
Pubmed

Aurora B expression in metastatic effusions from advanced-stage ovarian serous carcinoma is predictive of intrinsic chemotherapy resistance.

AURKA AURKB

2.29e-052167223114921
Pubmed

NKCC1-dependent GABAergic excitation drives synaptic network maturation during early hippocampal development.

SLC4A3 SLC12A2

2.29e-052167219295148
Pubmed

Validating Aurora B as an anti-cancer drug target.

AURKA AURKB

2.29e-052167216912073
Pubmed

Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.

AURKA AURKB

2.29e-052167223092930
Pubmed

Sepsis-Induced Immunosuppression Is Marked by an Expansion of a Highly Suppressive Repertoire of FOXP3+ T-Regulatory Cells Expressing TIGIT.

TIGIT FOXP3

2.29e-052167234379757
Pubmed

Expression of Cl- channels/transporters in nasal polyps.

CFTR SLC12A2

2.29e-052167232333139
Pubmed

Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

CBS MTRR

2.29e-052167222665368
Pubmed

Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.

NUP210 FOXP3

2.29e-052167230323813
Pubmed

Purging human ovarian cortex of contaminating leukaemic cells by targeting the mitotic catastrophe signalling pathway.

AURKC AURKB

2.29e-052167233725274
Pubmed

Deregulated expression of Aurora kinases is not a prognostic biomarker in papillary thyroid cancer patients.

AURKA AURKB

2.29e-052167225807528
Pubmed

An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.

AURKA AURKB

2.29e-052167222222631
Pubmed

True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product.

DDB1 DDB2

2.29e-052167212812979
Pubmed

Mitotic kinases as regulators of cell division and its checkpoints.

AURKA AURKB

2.29e-052167211413462
Pubmed

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.

AURKA AURKB

2.29e-052167210523496
Pubmed

Protein Kinase C-η Deficiency Does Not Impair Antiviral Immunity and CD8+ T Cell Activation.

PRKCH FOXP3

2.29e-052167232198145
Pubmed

High expression of AURKA and AURKB is associated with unfavorable cytogenetic abnormalities and high white blood cell count in patients with acute myeloid leukemia.

AURKA AURKB

2.29e-052167220732714
Pubmed

Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the normal and CFTR-deficient murine colon.

CFTR SLC12A2

2.29e-052167212692180
Pubmed

Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.

SLC4A3 SLC12A2

2.29e-052167218779325
Pubmed

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer.

DDB1 DDB2

2.29e-052167232739133
Pubmed

Homocysteine activates autophagy by inhibition of CFTR expression via interaction between DNA methylation and H3K27me3 in mouse liver.

CFTR CBS

2.29e-052167229415998
Pubmed

High aurora kinase expression identifies patients with muscle-invasive bladder cancer who have poor survival after neoadjuvant chemotherapy.

AURKA AURKB

2.29e-052167231597600
Pubmed

Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.

AURKA AURKB

2.29e-052167219059698
Pubmed

Proteomic Analysis of Nuclear Hepatitis B Virus Relaxed Circular DNA-Associated Proteins Identifies UV-Damaged DNA Binding Protein as a Host Factor Involved in Covalently Closed Circular DNA Formation.

DDB1 DDB2

2.29e-052167234705558
Pubmed

Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target.

AURKA AURKB

2.29e-052167222940834
Pubmed

Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2.

DDB1 DDB2

2.29e-052167212151405
Pubmed

Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.

DDB1 DDB2

2.29e-052167218936169
Pubmed

Aurora kinases as prognostic biomarkers in ovarian carcinoma.

AURKA AURKB

2.29e-052167219157502
Pubmed

Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.

AURKC AURKB

2.29e-052167234465813
Pubmed

Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.

F8 FOXP3

2.29e-052167236107620
Pubmed

Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis.

AURKC AURKB

2.29e-052167217192404
Pubmed

Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.

DDB1 DDB2

2.29e-052167214751237
Pubmed

DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.

DDB1 DDB2

2.29e-052167216223728
Pubmed

Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.

SLC4A3 SLC4A2

2.29e-052167211248201
Pubmed

Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia.

AURKA AURKB

2.29e-052167233277547
Pubmed

Thrombophilic polymorphisms and intrauterine growth restriction.

F8 SERPINE1

2.29e-052167215824541
Pubmed

Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells.

AURKA MMP2

2.29e-052167227125974
Pubmed

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.

AURKA AURKB

2.29e-052167211784863
Pubmed

Association of the AURKA and AURKC gene polymorphisms with an increased risk of gastric cancer.

AURKA AURKB

2.29e-052167227270838
Pubmed

The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.

IL4I1 FOXP3

2.29e-052167225778793
Pubmed

Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.

AURKC AURKB

2.29e-052167224586209
Pubmed

FCRL3 expression is upregulated and closely correlates with TIGIT expression in regulatory T cells of patients with systemic lupus erythematosus.

FCRL3 TIGIT

2.29e-052167238461541
Pubmed

Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

AURKA AURKB

2.29e-052167233172929
Pubmed

Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.

TRPV1 SLC12A2

2.29e-052167223139219
Pubmed

Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.

AURKC AURKB

2.29e-052167233172986
Pubmed

TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens.

TRPV1 SLC12A2

2.29e-052167232293931
Pubmed

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity.

AURKA AURKB

2.29e-052167233123754
Pubmed

Spindle assembly checkpoint gene expression in childhood adrenocortical tumors (ACT): Overexpression of Aurora kinases A and B is associated with a poor prognosis.

AURKA AURKB

2.29e-052167223788275
Pubmed

Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.

AURKA AURKB

2.29e-052167226141684
Pubmed

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.

CFTR ANO6

2.29e-052167222006324
Pubmed

New Treatment of Medullary and Papillary Human Thyroid Cancer: Biological Effects of Hyaluronic Acid Hydrogel Loaded With Quercetin Alone or in Combination to an Inhibitor of Aurora Kinase.

AURKA AURKB

2.29e-052167226660542
Pubmed

Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression.

AURKA AURKB

2.29e-052167225882311
Pubmed

Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis.

TG FOXP3

2.29e-052167217644307
Pubmed

Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.

CFTR SLC4A2

2.29e-052167226542396
Pubmed

Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.

FCRL3 FOXP3

2.29e-052167222341374
Pubmed

Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes.

AURKA AURKC

2.29e-052167235255953
Pubmed

Dynamics of DDB2-DDB1 complex under different naturally-occurring mutants in Xeroderma Pigmentosum disease.

DDB1 DDB2

2.29e-052167230251654
Pubmed

Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.

AURKA AURKC

2.29e-052167235218477
Pubmed

Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B.

AURKC AURKB

2.29e-052167224603334
Pubmed

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.

AURKC AURKB

2.29e-052167228369513
Pubmed

Overexpression of Aurora-A enhances invasion and matrix metalloproteinase-2 expression in esophageal squamous cell carcinoma cells.

AURKA MMP2

2.29e-052167222522455
Pubmed

Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen.

CFTR SLC12A2

2.29e-052167216093421
Pubmed

Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex.

DDB1 DDB2

2.29e-052167212050362
Pubmed

Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.

AURKA AURKB

2.29e-052167220865660
Pubmed

Damage sensor role of UV-DDB during base excision repair.

DDB1 DDB2

2.29e-052167231332353
Pubmed

Growth suppression and mitotic defect induced by JNJ-7706621, an inhibitor of cyclin-dependent kinases and aurora kinases.

AURKA AURKB

2.29e-052167222463590
Pubmed

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

FCRL3 TIGIT

2.29e-052167225762785
Pubmed

Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates.

DDB1 DDB2

2.29e-052167224760829
Pubmed

A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition.

AURKA AURKB

2.29e-052167226808391
Pubmed

Potentiation of ABCA3 lipid transport function by ivacaftor and genistein.

ABCA3 CFTR

2.29e-052167231210424
Pubmed

Studies of the murine DDB1 and DDB2 genes.

DDB1 DDB2

2.29e-052167210713455
Pubmed

Antiproliferative effect of Aurora kinase targeting in mesothelioma.

AURKA AURKB

2.29e-052167220371132
Pubmed

Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B.

AURKA AURKB

2.29e-052167225987563
Pubmed

Basolateral chloride transporters in autosomal dominant polycystic kidney disease.

CFTR SLC12A2

2.29e-052167212355171
Pubmed

Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis.

ITGAE FOXP3

2.29e-052167222068168
Pubmed

Gene expression profiles of the aurora family kinases.

AURKA AURKB

2.29e-052167216572587
Pubmed

Clinical significance of the expression of FOXP3 and TIGIT in Merkel cell carcinoma.

TIGIT FOXP3

2.29e-052167237573372
Pubmed

SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma.

SLC35E2B SLC35E2A

2.29e-052167235247439
Pubmed

Aurora kinases as targets in drug-resistant neuroblastoma cells.

AURKA AURKB

2.29e-052167225268132
GeneFamilyEF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2

DDB1 DDB2 GTF2H1

1.42e-041810431269
GeneFamilyG-patch domain containing|Minor histocompatibility antigens

GPATCH2 GPATCH8 GPANK1

2.63e-04221043579
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

KIF23 DPP3 AURKA TMUB1 MOGS FLAD1 YDJC AURKB

8.06e-0719916588ee3dbc0a92de5f3865e5484970ae2aab7d1a956
ToppCellTCGA-Bladder-Primary_Tumor|TCGA-Bladder / Sample_Type by Project: Shred V9

KIF23 DPP3 AURKA TMUB1 MOGS FLAD1 YDJC AURKB

8.06e-071991658c403e28def2e14f5931cd73b4fb9a4078c0439f8
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

DPP3 AURKA RHPN1 MOGS FLAD1 NUP210 ELF3 AURKB

8.37e-072001658e3ad8d592686a5d1e1fb8dd05c2f00eac4c5738f
ToppCellTCGA-Endometrium-Primary_Tumor|TCGA-Endometrium / Sample_Type by Project: Shred V9

DPP3 AURKA RHPN1 MOGS FLAD1 NUP210 ELF3 AURKB

8.37e-0720016581cbb62df4ea1631fef8497e1702175605d0869e7
ToppCellStriatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Striatum / BrainAtlas - Mouse McCarroll V32

CPA5 NDST4 CPS1 PROKR2 ADAMTS17 CORO6

1.47e-0695165656350551af6a1ae15652d596002124d8f7885d4f
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 GHDC CFTR MTMR1 DPP3 SERPINE1 AURKB

4.98e-0618016571bc01bb76d0d3f8db74f9244436d3e6d6015ed5d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 GHDC CFTR MTMR1 DPP3 SERPINE1 AURKB

4.98e-0618016572a28fbfe10a340c8662c2c8be33792f41fc09088
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

DMXL2 GHDC CFTR MTMR1 DPP3 SERPINE1 AURKB

4.98e-06180165712f3c4c4aa7fe03c0ef847bd4d4942c808015f5f
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CPA5 CDHR3 FCRL3 LRIG1 TIGIT EPB41 FOXP3

5.75e-06184165708bff25390e3484b75c860738396a405141b69fd
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A3 LRIG1 NFATC4 C11orf96 SERPINE1 JRKL NOTCH3

5.96e-06185165738486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A3 LRIG1 NFATC4 C11orf96 SERPINE1 JRKL NOTCH3

5.96e-0618516573c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCelldroplet-Kidney-nan-21m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG DDN IRX4 COL18A1 BST1 SP6 ELF3

6.17e-061861657393f00ea6b434d4c8854dd8070d176579b71cd3b
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CPA5 CDHR3 FCRL3 LRIG1 TIGIT EPB41 FOXP3

6.62e-0618816579db3d3010cb8a1f3ee1cdccaf3cbaac3cf983fc5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CPA5 CDHR3 FCRL3 LRIG1 TIGIT EPB41 FOXP3

6.62e-06188165772be6fe654f3a5f654d3b9680145bce7ae9b721d
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

ST6GALNAC1 DSC3 CFTR LRIG1 PROM2 ELF3 PLEKHA7

6.86e-06189165784d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellIPF-Epithelial-Goblet|World / Disease state, Lineage and Cell class

ST6GALNAC1 CFTR CBLC PTPRK PROM2 ELF3 SDK1

7.10e-061901657c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

DMXL2 ZC3H13 SIRPA DDB1 BST1 TNFAIP2 LY75

7.34e-0619116577bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellIPF-Epithelial-Basal|World / Disease state, Lineage and Cell class

ZCWPW2 DSC3 CBLC PTPRK PROM2 ELF3 SDK1

7.60e-0619216579b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

AHI1-DT ZCWPW2 CDHR3 PTPRK ELF3 SDK1 AURKB

8.69e-0619616576d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

AHI1-DT ZCWPW2 CDHR3 PTPRK ELF3 SDK1 AURKB

8.69e-061961657af4cdc61830685a888a1209826c23bcf54a43084
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGMB CFTR CBLC CPS1 SLC12A2 PROM2 ELF3

8.69e-06196165797324c9e93f833e1f218e81fb53066d44c6892df
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TRPV1 CFTR MAGI2 PLEKHG6 ELF3 NOTCH3 FOXP3

8.98e-06197165701e9505d947e5a5f005d1eab96301f84fc194809
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

INHBB HEG1 LRIG1 NFATC4 NUP210 PLEKHA7 NOTCH3

8.98e-06197165761749ccafeb938c310cff1de5ff924a1c794325a
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-epithelial_progenitor_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGMB CFTR CBLC CPS1 SLC12A2 PROM2 ELF3

8.98e-061971657c0250509836f1be04f5e54386191d7bb1e1da652
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

INHBB HEG1 LRIG1 NFATC4 NUP210 PLEKHA7 NOTCH3

8.98e-0619716579d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DSC3 CFTR CBLC PROM2 ELF3 SDK1 NOTCH3

9.28e-06198165719d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KIF23 DSC3 CBLC CPS1 AURKA AURKB PNLIPRP3

9.59e-06199165793450257180d918c310bca7b5defc74390c48091
ToppCelldistal-Epithelial-Proliferating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KIF23 DSC3 CBLC CPS1 AURKA AURKB PNLIPRP3

9.91e-06200165725cc494ef831511840d8c02ec1bd086635cc7edd
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-Treg|COVID-19_Mild / Disease, condition lineage and cell class

CPA5 CDHR3 FCRL3 LRIG1 TIGIT EPB41 FOXP3

9.91e-062001657c6ae15f7deba26008af5b647855675003bb2ebcd
ToppCelldistal-Epithelial-Proliferating_Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KIF23 DSC3 CBLC CPS1 AURKA AURKB PNLIPRP3

9.91e-062001657cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4-L1|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGMB RELN NDST4 CBLC MAGI2 PLEKHA7 SDK1

9.91e-062001657e2ced6eb1de9a526c34c7558b9c637854916e624
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-CHRNA4|Neuronal / cells hierarchy compared to all cells using T-Statistic

RGMB RELN NDST4 CBLC MAGI2 PLEKHA7 SDK1

9.91e-0620016579bc924755e5a4c464408e6103b86bf1b4e8c58b5
ToppCellICU-SEP-Lymphocyte-T_NK-CD8_Naive|ICU-SEP / Disease, Lineage and Cell Type

CPA5 DPP3 F8 TIGIT SERPINE1 PRKCH

1.98e-051491656a66f3ebf6214b269b137ddd5f4d8d7fb3ef2d962
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

PRTG AOC2 HEATR5A JARID2 JRKL EPB41

1.98e-051491656768877bade04ca0321593b8470b5011ad8270431
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CASP8AP2 FCRL3 TIGIT GAB4 EPB41 FOXP3

2.30e-0515316567480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CASP8AP2 FCRL3 TIGIT GAB4 EPB41 FOXP3

2.56e-05156165653ded973358e3e48054130131e959f0d1f4ef60f
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 SIRPA SNAI3 BST1 YDJC TNFAIP2

2.75e-051581656f61ebe3a316e4259387cd9da83707f15e6473cae
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST6GALNAC1 ACSM1 AURKA TIGIT AURKB FOXP3

3.39e-051641656e5258efd6765acfc394708f697ec76acaef09079
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-prox-progenitor_intermediate_|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ZCWPW2 CFTR NDST4 PLEKHG6 PROM2 ELF3

3.51e-051651656f6887c64af0f26e33316bc5587487e24d76ece2a
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intermediate_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

DMXL2 SIRPA AHRR TNFAIP2 MMP2 MN1

3.51e-051651656c3fa9225d2f9c9e821d4fbd2315fcc98ce1f1c55
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC1 CFTR SLC4A3 ELF3 IGSF1 PLEKHA7

3.75e-051671656cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 PLCD4 SIRPA MOGS TNFAIP2 LY75

3.88e-051681656a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LINC01547 CBLC MSH5 FCRL3 BST1 UTP14C

4.01e-051691656818ab7a6fd1940a22d3bd99fe15f0af888af6b3e
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ST6GALNAC1 CFTR SLC4A3 ELF3 IGSF1 PLEKHA7

4.01e-05169165630141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell356C-Epithelial_cells-Epithelial-D_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LINC01547 CBLC MSH5 FCRL3 BST1 UTP14C

4.01e-051691656f982f2e0d341fa27229f443ebe5c0e4a9e63bda6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

PRTG CFTR SLC12A2 LRIG1 PTPRK ELF3

4.15e-051701656269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RGMB KIF23 SIRPA MOGS TNFAIP2 LY75

4.28e-051711656845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAE LRIG1 TIGIT SP6 PRKCH FOXP3

4.28e-0517116568719a18c9e6b6f5d8ec4e937c2bda1e36441c9ec
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGAE LRIG1 TIGIT SP6 PRKCH FOXP3

4.28e-051711656f4cdd7862c8fe99ee765a2f3ed375b584f4976c5
ToppCellfacs-Heart-RV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN TIGIT NUP210 SP6 YDJC LY75

4.43e-05172165664d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCellNasal_Brush-Epithelial-Basal_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

ZCWPW2 DSC3 COL18A1 ZNF263 NFATC4 KLHDC8B

4.43e-05172165658eaadf12366701103a0d1f133462c9495fedc30
ToppCellfacs-Heart-RV-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN TIGIT NUP210 SP6 YDJC LY75

4.43e-0517216562dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCellNasal_Brush-Epithelial-Basal_1|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

ZCWPW2 DSC3 COL18A1 ZNF263 NFATC4 KLHDC8B

4.43e-0517216564483073469001770015526303772fd54906c5d68
ToppCellfacs-Heart-RV-18m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN TIGIT NUP210 SP6 YDJC LY75

4.43e-051721656d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DSC3 CBLC PROM2 ELF3 PLSCR2 VGLL1

4.72e-051741656edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

DSC3 CBLC PROM2 ELF3 PLSCR2 VGLL1

4.72e-05174165665539f69100db0b7d90b1b39ee15ab8281f86461
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 KIF23 SIRPA TNFAIP2 LY75 AURKB

4.72e-05174165665147b0f8c2ccadd5685430d31081520c157536a
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

DMXL2 GPATCH2 TIGIT SERPINE1 LY75 FOXP3

4.72e-05174165658300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35E2B ZNF461 ZNF75D TNFAIP2 SDK1

4.91e-051071655410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SLC35E2B ZNF461 ZNF75D TNFAIP2 SDK1

4.91e-0510716555bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 SIRPA TG BST1 TNFAIP2 LY75

5.03e-051761656b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCellsevere-Myeloid-Neutrophils_1|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

INHBB AOC2 TG TNFAIP2 STK40 EPB41

5.19e-051771656d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRTG SIRPA FMNL2 SLC4A3 ANO6 TNFAIP2

5.19e-05177165614fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 CFTR SLC35E2B ZNF461 ZNF75D ELF3

5.19e-051771656d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 CFTR SLC35E2B ZNF461 ZNF75D ELF3

5.19e-051771656ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCellClub_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ST6GALNAC1 INHBB PROM2 ELF3 SDK1 NOTCH3

5.36e-051781656be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|390C / Donor, Lineage, Cell class and subclass (all cells)

ST6GALNAC1 CBLC MAGI2 PROM2 ELF3 TNFAIP2

5.36e-051781656fce60ce6b662f1bdaa3b4da43800c6c22fe89533
ToppCell390C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|390C / Donor, Lineage, Cell class and subclass (all cells)

ST6GALNAC1 CBLC MAGI2 PROM2 ELF3 TNFAIP2

5.36e-051781656b19c906e067b07eadfd68934d9330b447e24c708
ToppCell10x5'v1-week_17-19-Lymphocytic_NK-T_NK-ILC_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RGMB PGLYRP2 CPS1 AHRR PRKCH IL4I1

5.52e-051791656d18a520568cf4b031972d3dd7d4d4bd073ac1fea
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGMB RELN NDST4 APOL5 MN1 SDK1

5.52e-051791656c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellT_cells-GZMK+_CD8+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SLF1 AOC2 TIGIT GYG1 TNFAIP2 EXOC2

5.52e-051791656798f208014f2229c597934775646ddbbacf94b69
ToppCelldroplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 SIRPA BST1 SERPINE1 TNFAIP2 LY75

5.88e-0518116568fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGMB NDST4 HEG1 PLEKHA7 MN1 SDK1

5.88e-0518116562f3d04d22d4ac016e61709ea5af3d48885c946c4
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 KIF23 MOGS TNFAIP2 LY75 AURKB

6.06e-05182165621dcab170ffeef89faa9fee5008568cb6e15c694
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL18A1 SLC12A2 PTPRK NFATC4 C11orf96 NOTCH3

6.06e-051821656fc4a5bf784705efe7965ce43ac23c2a8e602e90a
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC1 CFTR LRIG1 PROM2 ELF3 SDK1

6.06e-0518216563f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 SIRPA BST1 SERPINE1 TNFAIP2 LY75

6.06e-051821656be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABCA3 TSPEAR C1orf167 F8 SERPINE1 GPAT2

6.06e-051821656f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

ST6GALNAC1 CFTR LRIG1 PROM2 ELF3 SDK1

6.24e-051831656940cbe298e9c53b5622af09264586ed823d3141f
ToppCellmild_COVID-19_(asymptomatic)-T/NK_proliferative|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

KIF23 CPA5 LINC01547 LCT AURKA AURKB

6.24e-051831656df8568751205313d149939ea2683097e3652a60b
ToppCell10x5'-blood-Lymphocytic_T_CD4-Tregs|blood / Manually curated celltypes from each tissue

CDHR3 FCRL3 LRIG1 TIGIT EPB41 FOXP3

6.44e-05184165622c15ce30171c687ab564f4383ae74d38b759272
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 CFTR TSPEAR ADAMTS17 ELF3 PLEKHA7

6.63e-0518516560d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CFTR LRIG1 PTPRK ELF3 PLEKHA7 SDK1

6.63e-051851656cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RELN CDHR3 NIPSNAP1 COL18A1 PTPRK TMEM245

6.63e-0518516561d874608aa2062024323512f68889219471b2f00
ToppCell(230)_CD4+/CD25+_Reg_T_cell|World / immune cells in Peripheral Blood (logTPM normalization)

CPA5 FCRL3 LRIG1 TIGIT RPL3 FOXP3

6.63e-051851656f846166cec84985d6a09a45d045acd686174b6d9
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma|TCGA-Kidney / Sample_Type by Project: Shred V9

ACSM1 TMEM104 AXIN1 RHPN1 CORO6 ELF3

6.63e-05185165646f4f6f20b1e152922f6f2ba1244c56e48a49b79
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGMB SLC35E2B PLEKHG6 PROM2 BST1 ELF3

7.04e-05187165622fd1959879705a8c1128faa9de66696c4e0b7e3
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGMB SLC35E2B PLEKHG6 PROM2 BST1 ELF3

7.04e-0518716565fae538de481367cf6d9a2d52190d77b99f6922c
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGMB SLC35E2B PLEKHG6 PROM2 BST1 ELF3

7.04e-0518716560526c0a818cf28fd5b6ff65fe260e3c3a4a98a2a
ToppCellCOVID-19_Mild-Lymphoid_T/NK-Treg|COVID-19_Mild / Disease group, lineage and cell class

CPA5 CDHR3 LRIG1 TIGIT EPB41 FOXP3

7.25e-05188165642553fdc127e5f613ffd5067620a768a40f1a8a1
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

PRTG ABCA3 CFTR PTPRK MTRR ELF3

7.46e-051891656dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDHR3 ACSM1 PTPRK TNFAIP2 PLEKHA7 SDK1

7.46e-0518916563b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

ZCWPW2 CFTR PTPRK PROM2 ELF3 SDK1

7.46e-051891656f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellT_cells-GZMK+_CD8+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SLF1 AOC2 TIGIT GYG1 PRKCH EXOC2

7.46e-051891656e2ca075aedf7c370ab4ede6272254ffd06cbcdec
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

ZCWPW2 DSC3 CBLC PTPRK PROM2 ELF3

7.68e-051901656ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CPA5 LRIG1 TIGIT PRKCH EPB41 FOXP3

7.68e-051901656b69709323a9f1b368b5a4f87295b9f7fd9c9be8e
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

ST6GALNAC1 CFTR MAGI2 LRIG1 ELF3 NOTCH3

7.68e-051901656756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CBLC ELF3 TNFAIP2 PLSCR2 RPL3 NOTCH3

7.68e-0519016560bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ST6GALNAC1 CFTR PROM2 ELF3 PLEKHA7 SDK1

7.68e-05190165651ca9ef4df3220487152fcf684147730637c7cc1
ToppCell(7)_Epithelial-G_(Club-Clara_cells)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ST6GALNAC1 CBLC PROM2 ELF3 VGLL1 NOTCH3

7.68e-051901656593fd1451038b155826a48de4caa38f44406d0b9
Diseasebrain cancer (implicated_via_orthology)

AURKA AURKC NOTCH3 AURKB

1.05e-05261574DOID:1319 (implicated_via_orthology)
Diseasehomocystinuria (is_implicated_in)

CBS MTRR

2.81e-0521572DOID:9263 (is_implicated_in)
DiseaseCystathionine beta-Synthase Deficiency Disease

CBS MTRR

2.81e-0521572C0751202
DiseaseHomocystinuria

CBS MTRR

2.81e-0521572C0019880
Diseasecortical surface area measurement

PRTG RELN APCDD1 ZC3H13 FGFRL1 FRYL MSH5 CPS1 RGP1 FMNL2 KIAA1614 AXIN1 TG TIGD2 LRIG1 YDJC EXOC2 PLEKHA7 GPANK1 ARHGAP21

3.27e-05134515720EFO_0010736
Diseasecervical cancer

SIRPA MAGI2 JARID2 COL18A1

6.07e-05401574MONDO_0002974
Diseaseage at menarche

CPA5 NDST4 DDN MSH5 MAGI2 PTPRK TMEM245 SP6 IGSF1 PLEKHA7 KLHDC8B BRWD1

8.56e-0559415712EFO_0004703
DiseaseAutoimmune thyroiditis

TG FCRL3

1.68e-0441572C0920350
DiseaseCholedochal Cyst, Type I

CFTR SLC4A2

2.78e-0451572C0009439
DiseaseCholedochal Cyst, Type II

CFTR SLC4A2

2.78e-0451572C1257796
DiseaseCholedochal Cyst, Type III

CFTR SLC4A2

2.78e-0451572C1257797
DiseaseCholedochal Cyst, Type IV

CFTR SLC4A2

2.78e-0451572C1257798
DiseaseCholedochal Cyst, Type V

CFTR SLC4A2

2.78e-0451572C1257799
DiseaseCholedochal Cyst

CFTR SLC4A2

2.78e-0451572C0008340
Diseasemeningioma (is_implicated_in)

MTRR MN1

4.16e-0461572DOID:3565 (is_implicated_in)
Diseaseretinal vein occlusion (is_implicated_in)

SERPINE1 MMP2

5.80e-0471572DOID:1727 (is_implicated_in)
Diseaseglycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) measurement

CPS1 RGP1

7.71e-0481572EFO_0800533
Diseaseplasma betaine measurement

CPS1 CBS LY75

7.83e-04341573EFO_0007787
Diseasetropical spastic paraparesis (is_marker_for)

MMP2 FOXP3

9.88e-0491572DOID:321 (is_marker_for)
DiseaseAutosomal Recessive Polycystic Kidney Disease

CFTR SLC4A2

9.88e-0491572C0085548
Diseaseabdominal aortic aneurysm (implicated_via_orthology)

SERPINE1 MMP2

9.88e-0491572DOID:7693 (implicated_via_orthology)
Diseaseage at menopause

APCDD1 INHBB GEMIN5 FRYL MSH5 NMRK2 IL4I1

1.21e-033021577EFO_0004704
Diseasecutaneous leishmaniasis (is_marker_for)

MMP2 FOXP3

1.23e-03101572DOID:9111 (is_marker_for)
Diseaseresponse to carboplatin, response to antineoplastic agent

PRTG LRIG1

1.23e-03101572GO_0097327, GO_0097328
Diseaseglomerulosclerosis (implicated_via_orthology)

SERPINE1 PLEKHA7

1.50e-03111572DOID:0050851 (implicated_via_orthology)
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CFTR SLC4A2

1.50e-03111572DOID:0110861 (biomarker_via_orthology)
DiseaseHyperhomocysteinemia

CBS MTRR

1.50e-03111572C0598608
Diseasehyperhomocysteinemia (implicated_via_orthology)

CBS F8

1.50e-03111572DOID:9279 (implicated_via_orthology)
DiseaseMarfan Syndrome

CBS MMP2

1.50e-03111572C0024796
DiseaseAdenocarcinoma of large intestine

AXIN1 AURKA PRKCH STK40

1.75e-03961574C1319315
Diseasefocal segmental glomerulosclerosis (biomarker_via_orthology)

SERPINE1 MMP2

1.79e-03121572DOID:1312 (biomarker_via_orthology)
Diseasehomocysteine measurement

C1orf167 CPS1 CBS

1.90e-03461573EFO_0004578
Diseasedisease progression measurement, Crohn's disease

CDHR3 CBLC SDK1

2.02e-03471573EFO_0000384, EFO_0008336
DiseaseCongenital Hypothyroidism

TG IGSF1

2.11e-03131572C0010308
DiseaseMale sterility

CFTR AURKC MTRR

2.14e-03481573C0917731
DiseaseMale infertility

CFTR AURKC MTRR

2.14e-03481573C0021364
DiseaseSubfertility, Male

CFTR AURKC MTRR

2.14e-03481573C0848676
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

TXNDC11 FCRL3 SIGLEC6 PRKCH EXOC2

2.21e-031701575EFO_0000685, EFO_0007791, EFO_0007837
DiseaseGraves' disease (is_marker_for)

TG SERPINE1

2.82e-03151572DOID:12361 (is_marker_for)
Diseaseanemia (implicated_via_orthology)

SLC4A3 SLC4A2

2.82e-03151572DOID:2355 (implicated_via_orthology)
Diseasevision disorder

MAGI2 SDK1

3.21e-03161572MONDO_0021084
Diseasehippocampal atrophy

MAGI2 COL18A1 ARSB

3.33e-03561573EFO_0005039
DiseaseAdenocarcinoma of prostate

AXIN1 AURKA

5.02e-03201572C0007112
Diseasemyocardial infarction (implicated_via_orthology)

TRPV1 SERPINE1 MMP2

5.29e-03661573DOID:5844 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
EAVATRTALHGVKWP

ACIN1

1061

Q9UKV3
WTAGKHSEDGARPRL

AHRR

406

A9YTQ3
HSSRWAIRGRSKINP

LINC01547

141

P58512
PSEWDKRLSTHSPFR

EPB41

701

P11171
LSRHSIPRDKSLFWE

BST1

96

Q10588
ETERWGKPHVASLSF

SLC4A2

356

P04920
ERWGKPHVASLSFRS

SLC4A3

356

P48751
VKAAREAFPSWSSRS

ALDH8A1

51

Q9H2A2
RGQVSRAHASWKPRA

C1orf167

1151

Q5SNV9
KIADFGWSVHTPSLR

AURKC

181

Q9UQB9
SIVAVDWKHPRITSF

EIF2D

341

P41214
LHRFSLEGDAPVSWT

CFTR

666

P13569
KIADFGWSVHAPSSR

AURKA

271

O14965
LTKAPAHTFWRESCG

CBLC

151

Q9ULV8
HLPGRDLSWAKVFGI

ABCA3

1651

Q99758
SKHAPRGTHLWEFIR

ELF3

266

P78545
TWAKPGNRTHRILTD

ANKRD61

126

A6NGH8
RRSHPSLSFSWLSKA

AHI1-DT

246

P0C7V0
HPRAVTGFSWRKTSK

DMXL2

231

Q8TDJ6
TLEGWKATRRAHTLP

DDN

426

O94850
SWEKETPGERSHSRV

CASP8AP2

321

Q9UKL3
GPFSGREHLIRRKWS

ADAMTS17

171

Q8TE56
WSDVTPLRFSRIHDG

MMP2

151

P08253
AFRAKGRVPVLSWIH

MTMR1

281

Q13613
HVRSEESWKGQPSRS

OTUD4

1066

Q01804
GLEAKPRIWSLAHTA

IRX4

361

P78413
FHRVSGSEKITPRWE

ANO6

636

Q4KMQ2
HATPRGLRSGDRATW

AOC2

206

O75106
EVPRKRHLGDNTFWT

ANKRD53

481

Q8N9V6
NGFGTHTWFLKRIRS

RSPH10B

261

P0C881
NGFGTHTWFLKRIRS

RSPH10B2

261

B2RC85
PGLTFHWSVTKRDVL

NUP210

1206

Q8TEM1
SGLLKRRFHWTAPAA

PDHB

16

P11177
FARSHLRPKHAWAVS

P2RY11

136

Q96G91
TGSLSPFARWRHKLS

PNLIPRP3

346

Q17RR3
SLIIHRGGFFSPWKT

MAGI2

676

Q86UL8
SIHSVLFRKDPFLWR

KIAA0895

371

Q8NCT3
WFKGDRPLSLTERHH

LRIG1

726

Q96JA1
IGWSRSIGHRFKRSD

MBTD1

341

Q05BQ5
APDSLFAVRRHLWGS

FOXP3

301

Q9BZS1
VTHFPAWDTRAVAGR

GPANK1

306

O95872
PGSFLHKWSSSDDIR

GPR162

426

Q16538
EKRVDLKRSGWHTFP

INHBB

216

P09529
LKRSGWHTFPLTEAI

INHBB

221

P09529
LWPALRKHFRSSRGQ

MTRR

146

Q9UBK8
GSRPRGHRWSKKAEA

KIAA1614

651

Q5VZ46
VLKFSTGGSRHPAIW

CPA5

176

Q8WXQ8
HWDGLSASPSQRIRA

ITGAE

621

P38570
ASTGLLWKRAHAESP

MICU1

46

Q9BPX6
QRSGSRKRSWGHESP

GPATCH8

1001

Q9UKJ3
RISKHWSGFLREAFT

PLSCR2

246

Q9NRY7
GRDDTWRYKTPHRVA

EXOC2

436

Q96KP1
HSGWSRFRVLPQGLK

FGFRL1

71

Q8N441
FDLLRTWPHFTATVK

PGLYRP2

536

Q96PD5
WLVVSRLHTPSKFAD

NEMP2

366

A6NFY4
IFSFDGKDVLRHPTW

COL18A1

1671

P39060
FITSRKRGPLWNHED

FRYL

1756

O94915
KSLRFWGSVGPARVH

GHDC

471

Q8N2G8
EAFVALPRWSAKRTG

NRXN2

501

Q9P2S2
RRKREHSTLWFPEGF

NOTCH3

1666

Q9UM47
KGLSIWDTFSHTPLR

LCT

1401

P09848
FDKTPLSYTHWRAGR

LY75

1326

O60449
TQGSIEAHKRGSRFW

DPP3

286

Q9NY33
TWSPSKARLHLQGRS

F8

2221

P00451
PSAGWLTRFKQRHSI

JRKL

121

Q9Y4A0
LLKPRVVIDGSWHSF

NLRP5

1176

P59047
RKRNSSGPDLSWLHF

HEG1

276

Q9ULI3
TRLSHSGKRSWEEPN

MIEF1

61

Q9NQG6
LRTALPAWHKSIVSF

TWNK

356

Q96RR1
TGHWAPSDLKTLQRR

NDST4

726

Q9H3R1
KAAPFDRRATSLAWH

DDB2

106

Q92466
VGRSFSLSWRSHPDV

RALGAPA2

691

Q2PPJ7
RVGTKPSASLRWHQA

OXER1

241

Q8TDS5
DFTTLDSRKWLLHPG

RELN

2326

P78509
LADSRHLWSPFGLRS

MOGS

716

Q13724
KANTSSSIFLHWRRP

PRTG

731

Q2VWP7
IRTHRSFWDEVLGPT

PLEKHG6

216

Q3KR16
TKIPRWDLDRFHGTS

CPS1

771

P31327
RTHTEKRPFKWSEPS

IGSF1

751

Q8N6C5
DEKSHPFTNPRWATR

HEATR5A

1206

Q86XA9
FSSWATTDIRKHLPF

GYG1

171

P46976
WHSFTQPRLGEKLHR

DSC3

821

Q14574
RPSFWEARKHSLSVQ

DYTN

46

A2CJ06
WKESSHQGAAPRRVT

CDHR3

811

Q6ZTQ4
RSGHVLYSGWLRKSP

GAB4

36

Q2WGN9
AEFRGSTHRIPWSLA

GAB4

281

Q2WGN9
RRAQSSFAWGLEPHS

AXIN1

556

O15169
PKSWESLFHRSITDL

GPAT2

56

Q6NUI2
RFDSPESHVGVAWRL

CBS

196

P35520
DSRSHPRSLEKSAWR

APCDD1

31

Q8J025
SKRVGILSWHPTARN

CORO6

131

Q6QEF8
TVWKGSAFAALHRGR

BRWD1

121

Q9NSI6
KPWSRSIEDLHRGSN

FMNL2

166

Q96PY5
GTVTFSWHKEGRVRS

FCRL3

316

Q96P31
SDWLPTLVKLARGHT

ARSB

351

P15848
FDLEHGSWTKLPRSL

KLHDC8B

251

Q8IXV7
WLGGIKSFTPRHAIT

GLIPR1L1

101

Q6UWM5
VRGKRPLWHESDFAV

GPATCH2

136

Q9NW75
GWEKLSLVPSSARLH

FLAD1

216

Q8NFF5
KAEAGPFSWITLVRH

ERVFC1

221

P60507
GATHDPRVSLRYVWK

SDK1

596

Q7Z5N4
HKPFIIIARAWSSGG

PKD1L1

136

Q8TDX9
SFWRSFHTERKTEPA

DDB1

1071

Q16531
LGWASHREVPGSKRS

PTPRK

1336

Q15262
KSEPFSRHGWNLTVL

JARID2

881

Q92833
RSRSAGDRWVDHKPA

KIF23

811

Q02241
PHGWVETAVKSALRA

IL4I1

486

Q96RQ9
GQWKTPFPDSSTHRR

SERPINE1

196

P05121
DAKARASVPTWRSLH

MN1

1291

Q10571
GEKLLRLWFTRPTHD

MSH5

266

O43196
AWLSSPQKFARAHGV

NMRK2

71

Q9NPI5
GSWFRSLFVHKVDPR

NIPSNAP1

41

Q9BPW8
RKERWHIFPSSGNGT

RGMB

401

Q6NW40
SIHDARSWVPKRQFG

STK40

391

Q8N2I9
TVWHARQARGSAKPS

PLCD4

46

Q9BRC7
AKHWFSSLRPSRNVV

SNAP47

121

Q5SQN1
RGLHPFVRTEAWKFL

TBC1D21

56

Q8IYX1
WSKARIGGHSPIFRT

NFATC4

386

Q14934
HPRTRYSAGWDAKLL

RDH16

276

O75452
AWHPARVAFSVARAG

RPL3

256

P39023
KWRLHFEFVTSREPG

RGP1

321

Q92546
EHWARAQKGDSRSLP

PLEKHA7

436

Q6IQ23
SLSLFVHWKPEGRAG

SIGLEC6

331

O43699
SKTLDGAHWRIYRPT

ST6GALNAC1

506

Q9NSC7
ESHGFSPRDITLKWF

SIRPA

171

P78324
PLSWGSLFGHRSEKI

SLC35E2A

26

P0CK97
LKAHLRWHSGDRPFV

SP6

271

Q3SY56
VFSAKNRWRLVGPVH

RHPN1

501

Q8TCX5
KAFSRPWLLQGHVRT

SNAI3

216

Q3KNW1
GPAKRAVWVRHTSSE

ACTL7A

36

Q9Y615
NFVAKRHIPFWTARG

APOL5

261

Q9BWW9
WLDFRSLVKSASPEH

ACSM1

196

Q08AH1
AGRARFKWHSLSSEL

C11orf96

191

Q7Z7L8
IADFGWSVHAPSLRR

AURKB

216

Q96GD4
ASSGWLTRFKQRHGI

TIGD2

121

Q4W5G0
IAWAPEGKDRFTISH

GTF2H1

31

P32780
LFKRFTHTRWAAPVE

TNFAIP2

476

Q03169
KVFSVWPSGARSEQR

ZNF488

146

Q96MN9
HRWFFTSARPGDLHV

TSR1

131

Q2NL82
AIAPIEHALSGWKAR

UTP14C

166

Q5TAP6
SRVSGRHWKNFALVP

TRPV1

781

Q8NER1
AEHLTFTPAARARWL

PROM2

36

Q8N271
FLSSPRHKEWLFASR

VPS18

526

Q9P253
FSVFHASLAKSPGWR

SLC12A2

691

P55011
KITSVAWSPHHDGRL

GEMIN5

641

Q8TEQ6
GVSNKHRSPFRHTFW

TMEM104

456

Q8NE00
AVGPFSRHGLRWTDA

YDJC

191

A8MPS7
ISHEDGTLWRRQTPK

NUP188

486

Q5SRE5
HWRPSQRGSKSSADL

PROKR2

351

Q8NFJ6
PLSWGSLFGHRSEKI

SLC35E2B

26

P0CK96
SRPGLRLWKADVHGT

TECPR2

236

O15040
HVVPRGTASATKWAF

TECPR2

1111

O15040
ADLGWHISPSFKDRV

TIGIT

71

Q495A1
WREELKRTGAPGAFH

SLF1

111

Q9BQI6
QETLFRWLRPHGGKS

TXNDC11

351

Q6PKC3
PFKSSLTRLGRHWLQ

TMEM245

96

Q9H330
GDTHSVQKWHRAFPR

ZNF75D

321

P51815
GAKYRPDWTRDSTHL

XRCC1

346

P18887
SFRSPALVDGRWHTL

TSPEAR

146

Q8WU66
FLGDPHSRSWIKATF

ZCWPW2

141

Q504Y3
VARAWPHDTIGSLKR

TMUB1

116

Q9BVT8
DAAKEGWLHFRPLVT

ARHGAP21

931

Q5T5U3
HDLFSSPEKRWASPR

TG

386

P01266
RRASVRPGELWHFSS

VGLL1

121

Q99990
GKAFIWSSGLTEHRR

ZNF726P1

136

Q15940
KRASAGLQRVHEPTW

TMEM234

26

Q8WY98
LSPSHLTEDRQGRWK

ZC3H13

876

Q5T200
FKSHSPERSIFSAIW

ZNF461

131

Q8TAF7
WGHQDPSKRALSRDT

ZNF263

231

O14978
GLQPTRWSLRHSLFK

PRKCH

21

P24723
VDAGFVWTEPHSKRL

NMD3

96

Q96D46