Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNMB2 CACNA1E PANX1 SLC1A3 SLC1A6 RYR2 RYR3 ATP2C1 SCN1A SCN2A SCN3A SCN5A

1.30e-0546511312GO:0046873
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN5A

1.32e-05261134GO:0005248
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A

6.14e-05141133GO:0031402
GeneOntologyMolecularFunctioncalcium ion binding

CACNA1E CABP5 PCDHGB3 S100A7L2 ASAH2 EFHD2 ACTN3 RYR2 RYR3 MYOF ATP2C1 ITSN2 PITPNM3 AIF1

8.53e-0574911314GO:0005509
GeneOntologyMolecularFunctionactin binding

HDAC6 SPATA31A3 SYNE1 SPATA31A7 TMOD3 PANX1 ACTN3 SPATA31A6 SPATA31A5 SPATA31A1 AIF1

8.69e-0547911311GO:0003779
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNMB2 CACNA1E PANX1 RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

1.46e-043431139GO:0005261
GeneOntologyMolecularFunctionmodification-dependent protein binding

MBTD1 HDAC6 KDM5A TNIP1 ZRANB3 PARP10 L3MBTL1

1.72e-042061137GO:0140030
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR2 RYR3

1.89e-0441132GO:0005219
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN5A

2.13e-04521134GO:0005272
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNMB2 CACNA1E PANX1 SLC1A3 SLC1A6 RYR2 RYR3 ATP2C1 SCN1A SCN2A SCN3A SCN5A

2.27e-0462711312GO:0022890
GeneOntologyMolecularFunctionhigh-affinity L-glutamate transmembrane transporter activity

SLC1A3 SLC1A6

3.14e-0451132GO:0005314
GeneOntologyMolecularFunctionglutamate:sodium symporter activity

SLC1A3 SLC1A6

3.14e-0451132GO:0015501
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

HDAC6 TNIP1 ZRANB3 PARP10

3.48e-04591134GO:0031593
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNMB2 CACNA1E PANX1 SLC1A3 SLC1A6 RYR2 RYR3 ATP2C1 SCN1A SCN2A SCN3A SCN5A

3.82e-0466411312GO:0008324
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A

4.17e-04261133GO:0031420
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC1A3 SLC1A6 SCN1A SCN2A SCN3A SCN5A

4.28e-041711136GO:0015081
GeneOntologyMolecularFunctioncytoskeletal protein binding

HDAC6 SPATA31A3 RTCB KIF26B SYNE1 SPATA31A7 EML6 TMOD3 PANX1 ACTN3 SPATA31A6 SPATA31A5 SPATA31A1 SCN5A AIF1 KIF3C

4.58e-04109911316GO:0008092
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR2 RYR3

4.69e-0461132GO:0048763
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNMB2 CACNA1E PANX1 RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

1.20e-034591139GO:0005216
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNMB2 CACNA1E PANX1 SLC1A3 SLC1A6 RYR2 RYR3 ATP2C1 SCN1A SCN2A SCN3A SCN5A

1.22e-0375811312GO:0015318
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1E PANX1 RYR2 RYR3 ATP2C1

1.69e-031511135GO:0015085
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNMB2 CACNA1E PANX1 SLC1A3 SLC1A6 RYR2 RYR3 ATP2C1 SCN1A SCN2A SCN3A SCN5A

1.78e-0379311312GO:0015075
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

1.13e-06621136GO:0086002
GeneOntologyBiologicalProcesstransmission of nerve impulse

KCNMB2 CACNA1E SCN1A SCN2A SCN3A SCN5A TNR

2.77e-061121137GO:0019226
GeneOntologyBiologicalProcesscardiac muscle cell action potential

RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

8.33e-06871136GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

1.22e-05931136GO:0086003
GeneOntologyBiologicalProcessneuronal action potential

KCNMB2 SCN1A SCN2A SCN3A SCN5A

2.46e-05631135GO:0019228
GeneOntologyBiologicalProcessstriated muscle contraction

ACTN3 RYR2 RYR3 GPD1L SCN1A SCN2A SCN3A SCN5A

2.62e-052171138GO:0006941
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN5A

4.39e-05361134GO:0086010
GeneOntologyBiologicalProcessmuscle contraction

TMOD3 ACTN3 RYR2 RYR3 GPD1L MYOF SCN1A SCN2A SCN3A SCN5A

7.08e-0540011310GO:0006936
GeneOntologyBiologicalProcessactin-mediated cell contraction

RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

7.14e-051271136GO:0070252
GeneOntologyBiologicalProcessaction potential

KCNMB2 RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

1.21e-042011137GO:0001508
GeneOntologyBiologicalProcessactin filament-based process

ILK HDAC6 TMOD3 ACTN3 PIP5K1C RYR2 ARF6 GPD1L ATP2C1 ABI2 SCN1A SCN2A SCN3A SCN5A AIF1

1.36e-0491211315GO:0030029
GeneOntologyBiologicalProcesssynaptic vesicle endocytosis

BTBD8 SH3GL3 PIP5K1C ARF6 ITSN2

1.86e-04961135GO:0048488
GeneOntologyBiologicalProcessactin filament-based movement

RYR2 GPD1L SCN1A SCN2A SCN3A SCN5A

1.99e-041531136GO:0030048
GeneOntologyBiologicalProcessmuscle system process

TMOD3 ACTN3 RYR2 RYR3 GPD1L MYOF SCN1A SCN2A SCN3A SCN5A AIF1

2.09e-0454711311GO:0003012
GeneOntologyBiologicalProcesspresynaptic endocytosis

BTBD8 SH3GL3 PIP5K1C ARF6 ITSN2

2.46e-041021135GO:0140238
GeneOntologyCellularComponentsarcomere

ILK SYNE1 BAG3 TMOD3 ACTN3 RYR2 RYR3 UNC45B SCN1A SCN5A

1.20e-0624911510GO:0030017
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN5A

1.96e-06171154GO:0001518
GeneOntologyCellularComponentmyofibril

ILK SYNE1 BAG3 TMOD3 ACTN3 RYR2 RYR3 UNC45B SCN1A SCN5A

2.74e-0627311510GO:0030016
GeneOntologyCellularComponentcontractile muscle fiber

ILK SYNE1 BAG3 TMOD3 ACTN3 RYR2 RYR3 UNC45B SCN1A SCN5A

4.68e-0629011510GO:0043292
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN5A

1.86e-05291154GO:0034706
GeneOntologyCellularComponentacrosomal vesicle

SPATA31A3 SPATA31A7 SH3GL3 SPATA31A6 SPATA31A5 SPATA31A1 MROH2B DPEP3

1.86e-052061158GO:0001669
GeneOntologyCellularComponentZ disc

BAG3 ACTN3 RYR2 RYR3 UNC45B SCN1A SCN5A

2.04e-051511157GO:0030018
GeneOntologyCellularComponentsupramolecular fiber

ILK HDAC6 DNAH10 KIF26B SYNE1 FBF1 BAG3 EML6 TMOD3 ACTN3 RYR2 RYR3 KLHL22 ABI2 UNC45B SCN1A SCN5A AIF1 KIF3C

2.25e-05117911519GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

ILK HDAC6 DNAH10 KIF26B SYNE1 FBF1 BAG3 EML6 TMOD3 ACTN3 RYR2 RYR3 KLHL22 ABI2 UNC45B SCN1A SCN5A AIF1 KIF3C

2.47e-05118711519GO:0099081
GeneOntologyCellularComponentI band

BAG3 ACTN3 RYR2 RYR3 UNC45B SCN1A SCN5A

3.74e-051661157GO:0031674
GeneOntologyCellularComponentcation channel complex

KCNMB2 CACNA1E RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

4.77e-052351158GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNMB2 CACNA1E RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

1.17e-033781158GO:0034702
GeneOntologyCellularComponentpresynapse

CACNA1E ILK BTBD8 SH3GL3 SCRN1 PIP5K1C SLC1A6 ARF6 MYOF SCN1A SCN2A ITSN2 KIF3C

1.18e-0388611513GO:0098793
GeneOntologyCellularComponentplasma membrane raft

HDAC6 ASAH2 MS4A4A MYOF SCN5A

1.33e-031471155GO:0044853
GeneOntologyCellularComponentcell-cell junction

ILK FBF1 TMOD3 PANX1 PIP5K1C SAPCD2 ABI2 SCN1A SCN2A SCN5A

1.58e-0359111510GO:0005911
MousePhenoventricular fibrillation

RYR2 SCN1A SCN5A

9.17e-067913MP:0006110
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A

1.82e-0861124PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A SCN5A

1.82e-0861124IPR024583
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN5A

2.50e-07101124IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN5A

2.50e-07101124IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN5A

2.50e-07101124PF06512
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5

5.84e-07121124PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5

5.84e-07121124IPR027970
DomainIon_trans_dom

CACNA1E RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

5.60e-061141127IPR005821
DomainIon_trans

CACNA1E RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

5.60e-061141127PF00520
DomainEF-hand-dom_pair

CABP5 S100A7L2 EFHD2 ACTN3 RYR2 RYR3 SCN1A SCN3A ITSN2 AIF1

8.94e-0628711210IPR011992
DomainEF_HAND_2

CACNA1E CABP5 S100A7L2 EFHD2 ACTN3 RYR2 RYR3 ITSN2 AIF1

1.06e-052311129PS50222
DomainEF_hand_dom

CACNA1E CABP5 S100A7L2 EFHD2 ACTN3 RYR2 RYR3 ITSN2 AIF1

1.09e-052321129IPR002048
DomainChannel_four-helix_dom

CACNA1E SCN1A SCN2A SCN3A SCN5A

2.32e-05571125IPR027359
Domain-

CACNA1E SCN1A SCN2A SCN3A SCN5A

2.32e-055711251.20.120.350
DomainRyanodine_rcpt

RYR2 RYR3

1.07e-0431122IPR003032
DomainRyanrecept_TM4-6

RYR2 RYR3

1.07e-0431122IPR009460
DomainRyR

RYR2 RYR3

1.07e-0431122PF02026
DomainRR_TM4-6

RYR2 RYR3

1.07e-0431122PF06459
DomainRyan_recept

RYR2 RYR3

1.07e-0431122IPR013333
DomainIQ

IQCA1 SCN1A SCN2A SCN3A SCN5A

1.26e-04811125SM00015
DomainIQ_motif_EF-hand-BS

IQCA1 SCN1A SCN2A SCN3A SCN5A

2.08e-04901125IPR000048
DomainIQ

IQCA1 SCN1A SCN2A SCN3A SCN5A

2.42e-04931125PS50096
DomainRIH_assoc-dom

RYR2 RYR3

5.26e-0461122IPR013662
DomainIns145_P3_rec

RYR2 RYR3

5.26e-0461122PF08709
DomainRIH_assoc

RYR2 RYR3

5.26e-0461122PF08454
DomainRIH_dom

RYR2 RYR3

5.26e-0461122IPR000699
DomainIns145_P3_rcpt

RYR2 RYR3

5.26e-0461122IPR014821
DomainRyanodine_recept-rel

RYR2 RYR3

5.26e-0461122IPR015925
Domain-

RYR2 RYR3

5.26e-04611221.25.10.30
DomainRYDR_ITPR

RYR2 RYR3

5.26e-0461122PF01365
DomainNA_DICARBOXYL_SYMP_1

SLC1A3 SLC1A6

7.34e-0471122PS00713
DomainNA_DICARBOXYL_SYMP_2

SLC1A3 SLC1A6

7.34e-0471122PS00714
DomainSDF

SLC1A3 SLC1A6

7.34e-0471122PF00375
Domain-

SLC1A3 SLC1A6

7.34e-04711221.10.3860.10
DomainNa-dicarboxylate_symporter

SLC1A3 SLC1A6

7.34e-0471122IPR001991
DomainNa-dicarboxylate_symporter_CS

SLC1A3 SLC1A6

7.34e-0471122IPR018107
Domain-

CABP5 EFHD2 ACTN3 RYR2 RYR3 ITSN2 AIF1

1.00e-0326111271.10.238.10
DomainMBT

MBTD1 L3MBTL1

1.25e-0391122SM00561
DomainMBT

MBTD1 L3MBTL1

1.25e-0391122PS51079
DomainMIR

RYR2 RYR3

1.55e-03101122PF02815
DomainMBT

MBTD1 L3MBTL1

1.55e-03101122PF02820
DomainMIR_motif

RYR2 RYR3

1.55e-03101122IPR016093
DomainMbt

MBTD1 L3MBTL1

1.55e-03101122IPR004092
DomainMIR

RYR2 RYR3

1.55e-03101122PS50919
DomainMIR

RYR2 RYR3

1.55e-03101122SM00472
DomainEF-hand_1

CABP5 ACTN3 RYR2 RYR3 ITSN2

2.23e-031521125PF00036
DomainEFh

CABP5 EFHD2 ACTN3 RYR2 ITSN2

2.64e-031581125SM00054
DomainATPase_dyneun-rel_AAA

DNAH10 VWA8

3.09e-03141122IPR011704
DomainAAA_5

DNAH10 VWA8

3.09e-03141122PF07728
DomainSpectrin_alpha_SH3

SH3GL3 ITSN2

3.56e-03151122IPR013315
DomainARM-type_fold

PDCD4 RYR3 PPP4R3B UNC45B MROH2B CTNNBL1 LRBA

4.35e-033391127IPR016024
PathwayREACTOME_MUSCLE_CONTRACTION

TMOD3 ACTN3 RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

3.27e-05203868M5485
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1E RYR2 RYR3

3.49e-0511863M47958
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN5A

3.58e-0531864M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN5A

4.08e-0532864M27455
PathwayREACTOME_CARDIAC_CONDUCTION

RYR2 RYR3 SCN1A SCN2A SCN3A SCN5A

1.41e-04130866M27454
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1

2.17e-126115520850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1

2.17e-126115525930072
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

HDAC6 DNAH10 SYNE1 ZNF318 BIRC6 RYR2 RYR3 FSIP2 DPEP3

5.24e-09168115930631154
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN5A

1.41e-089115416382098
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A SCN5A

1.41e-089115415746173
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5 SPATA31A1

1.46e-0824115532212159
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

3.52e-083115323859570
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

3.52e-083115312610651
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

3.52e-083115318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

3.52e-083115317544618
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

3.52e-083115314973256
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A SCN5A

5.50e-0812115430175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN5A

7.93e-0813115415123669
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

1.41e-074115317537961
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

1.41e-074115335801810
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

1.41e-074115335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

1.41e-074115329578003
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

1.41e-07411538974318
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MYC CAAP1 MBTD1 HDAC6 VWA8 KDM5A FBF1 TMOD3 ZNF318 SIK3 DDB1 NKRF ATP2C1 TAF9B SCN5A CTNNBL1 CRYBG3

1.63e-0711161151731753913
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

3.50e-07511531679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

3.50e-07511538812438
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

3.50e-075115324337656
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN5A

3.50e-075115317724025
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYC MIS18BP1 DIS3L2 ILK HDAC6 RTCB BAG3 WDR70 BMS1 RPSA BIRC6 DDB1 NKRF SRRT SBF1 CTNNBL1 DDX60L PCNA

4.95e-0713531151829467282
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A

6.99e-076115323652591
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1E KDM5A SYNE1 EFHD2 ZNF318 SIK3 DDB1 TMEM132B SLC1A3 MAP3K5 SBF1 ABI2 MAD1L1 TNR GOLGB1

7.05e-079631151528671696
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SYNE1 BIRC6 MYOF RIMKLB AARS2 ITSN2

1.26e-06103115610574462
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

VWA8 RBMS2 BAG3 BMS1 ZNF318 SIK3 NCLN DDB1 SLC1A3 ARF6 ATP2C1 GOLGB1 EIF4E2

1.35e-067541151333060197
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CAAP1 MACC1 RTCB KDM5A SYNE1 MKRN1 BMS1 EFHD2 RPSA ZNF318 NKRF SRRT MYOF SBF1 ABI2 ITSN2 CTNNBL1 GOLGB1

2.09e-0614971151831527615
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

ILK HDAC6 RTCB RBMS2 BAG3 BMS1 EFHD2 RPSA GPRIN1 DDB1 PARP10 MYOF AARS2 CTNNBL1 MMUT GOLGB1 PCNA

2.65e-0613671151732687490
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

DIS3L2 SYNE1 BAG3 TMOD3 SCRN1 RPSA NCLN ARF6 MYOF SCN2A DDX3Y PCNA GULP1

2.70e-068031151336517590
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

CAAP1 HDAC6 RTCB VWA8 KDM5A SYNE1 BMS1 RPSA SIK3 DDB1 NKRF SRRT SBF1 CTNNBL1 DDX3Y

2.96e-0610821151538697112
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

ILK HDAC6 KIF26B RBMS2 MKRN1 TMOD3 EFHD2 RPSA ZNF318 SIK3 AARS2 SBF1

3.19e-066891151236543142
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

ILK HDAC6 RTCB VWA8 BAG3 EFHD2 RPSA NCLN BIRC6 DDB1 SLC1A3 PDCD4 SRRT CTNNBL1 GOLGB1 PCNA EIF4E2

4.19e-0614151151728515276
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

BTBD8 RTCB SYNE1 TMOD3 SCRN1 EFHD2 RPSA ACTN3 DDB1 SLC1A3 GPD1L SRRT SBF1 SCN2A ITSN2 DDX3Y TNR

4.86e-0614311151737142655
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ILK RTCB KDM5A KIF26B BAG3 SIK3 FSIP2 SRRT SBF1 MAD1L1 CRYBG3 GOLGB1 EIF4E2

5.74e-068611151336931259
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

PCDHGB3 KIF26B BMS1 PIWIL2 GPRIN1 BIRC6 TMEM132B SCN3A CTNNBL1 PITPNM3 EEF1AKMT1 TNR

6.23e-067361151229676528
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNMB2 CACNA1E RYR2 SCN1A SCN3A SCN5A

7.20e-06139115616985003
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

7.58e-061211538169823
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

ASNSD1 RTCB VWA8 SYNE1 TMOD3 EFHD2 SLC1A6 MYOF ATP2C1 CTNNBL1 GOLGB1 PCNA

7.94e-067541151235906200
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

MYC HDAC6 RTCB RBMS2 WDR70 TBC1D2B TNIP1 RPSA BLZF1 SAPCD2 PDCD4 SRRT RIMKLB EIF4E2

8.85e-0610381151426673895
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

SYNE1 SCRN1 TNIP1 SIK3 BIRC6 HEPH MYOF

1.05e-05225115712168954
Pubmed

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.

SLC1A3 SLC1A6

1.08e-052115229741614
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

1.08e-052115220346423
Pubmed

Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.

ZRANB3 PCNA

1.08e-052115228886337
Pubmed

The Antiresection Activity of the X Protein Encoded by Hepatitis Virus B.

WDR70 DDB1

1.08e-052115230791110
Pubmed

Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.

RYR2 SCN5A

1.08e-052115223723061
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

1.08e-052115210827969
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

1.08e-052115219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

1.08e-052115211245985
Pubmed

Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome.

MYC MAD1L1

1.08e-052115224095110
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

1.08e-05211521317301
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

1.08e-052115223016767
Pubmed

Correlation of MACC1/c-Myc Expression in Endometrial Carcinoma with Clinical/Pathological Features or Prognosis.

MYC MACC1

1.08e-052115229984790
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

1.08e-052115227153334
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

1.08e-052115224990319
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

1.08e-052115231439038
Pubmed

Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses.

SLC1A3 SLC1A6

1.08e-052115216177048
Pubmed

Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.

MYC PDCD4

1.08e-052115221643008
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

1.08e-05211528898078
Pubmed

Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4.

SLC1A3 SLC1A6

1.08e-052115216647773
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

1.08e-052115214550562
Pubmed

ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.

ZRANB3 PCNA

1.08e-052115222759634
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

1.08e-052115215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

1.08e-052115227690330
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

1.08e-052115223965409
Pubmed

Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating.

SCN2A SCN5A

1.08e-052115216847056
Pubmed

Chondroitin sulfate proteoglycan tenascin-R regulates glutamate uptake by adult brain astrocytes.

SLC1A3 TNR

1.08e-052115224337573
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

1.08e-052115230693367
Pubmed

Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.

RYR2 SCN5A

1.08e-052115226289036
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

1.08e-052115229649454
Pubmed

Cardiac Na+ current regulation by pyridine nucleotides.

GPD1L SCN5A

1.08e-052115219745168
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

1.08e-052115221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

1.08e-052115216678258
Pubmed

Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias.

GPD1L SCN5A

1.08e-052115217967977
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

1.08e-052115233096315
Pubmed

Genetic analysis in post-mortem samples with micro-ischemic alterations.

RYR2 SCN5A

1.08e-052115228086167
Pubmed

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

SCN1A SCN5A

1.08e-052115216054936
Pubmed

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.

SCN1A SCN5A

1.08e-052115233712547
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

1.08e-052115226311622
Pubmed

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

ZRANB3 PCNA

1.08e-052115222704558
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

1.08e-052115221377452
Pubmed

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A.

GPD1L SCN5A

1.08e-052115219666841
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

1.08e-052115214985349
Pubmed

ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma.

SLC1A3 MAP3K5

1.08e-052115220489729
Pubmed

Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.

MYC RPSA PDCD4 NKRF ARF6

1.27e-0590115528978906
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

RTCB BAG3 WDR70 TMOD3 RPSA ZNF318 GPRIN1 DDB1 PDCD4 NKRF LRBA GOLGB1 PCNA

1.36e-059341151333916271
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

1.56e-051511539726281
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

FBF1 MKRN1 SH3GL3 TNIP1 RPSA DDB1 SRRT L3MBTL1 ABI2 MAD1L1

1.78e-055601151021653829
Pubmed

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.

SYNE1 TBC1D2B TMOD3 SCRN1 EFHD2 GPRIN1 LRBA GOLGB1

1.80e-05339115837232246
Pubmed

Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.

BMS1 NCLN PCNA

1.91e-0516115317408621
Pubmed

Human transcription factor protein interaction networks.

MYC ASNSD1 MBTD1 DNAH10 RTCB KDM5A BMS1 TMOD3 TNIP1 RPSA ZNF318 DDB1 NKRF SRRT TAF9B PCNA

1.97e-0514291151635140242
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

ILK RTCB BAG3 TMOD3 SCRN1 EFHD2 RPSA BIRC6 DDB1 PDCD4 PPP4R3B SRRT ABI2 MAD1L1 LRBA PCNA

2.45e-0514551151622863883
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

CAAP1 RTCB KDM5A BMS1 RPSA NCLN PDCD4 NKRF ARF6 PPP4R3B TAF9B CTNNBL1 DDX3Y LRBA PCNA

3.04e-0513181151530463901
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

3.24e-053115219284629
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR2 RYR3

3.24e-053115218403125
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

3.24e-053115232185219
Pubmed

KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion.

MYC ARF6

3.24e-053115237158894
Pubmed

Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.

MYC MAD1L1

3.24e-053115212234922
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

3.24e-053115232005694
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

1.72e-0481152chr9q12
Cytoband2q24.3

SCN1A SCN2A

7.29e-041611522q24.3
Cytoband1q24

BLZF1 TNR

1.15e-032011521q24
Cytoband9p13.1

SPATA31A3 SPATA31A1

1.66e-032411529p13.1
CytobandEnsembl 112 genes in cytogenetic band chr2q32

ASNSD1 FSIP2 GULP1

2.72e-031101153chr2q32
Cytoband2p16.1

EML6 PPP4R3B

2.94e-033211522p16.1
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN5A

2.01e-0896641203
GeneFamilyEF-hand domain containing

CACNA1E CABP5 S100A7L2 EFHD2 RYR2 RYR3 ITSN2 AIF1

1.28e-06219668863
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR2 RYR3

3.93e-053662287
GeneFamilySterile alpha motif domain containing|MBT domain containing

MBTD1 L3MBTL1

4.65e-0496621263
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KCNMB2 SAPCD2 FSIP2 SCN1A SCN2A SCN3A TNR

1.52e-07155114777fdae85d36efb776db977eb424b32487ef222e4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 EML6 TMEM132B RYR2 SCN1A SCN2A SCN3A

7.95e-0719811476d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 EML6 TMEM132B RYR2 SCN1A SCN2A SCN3A

7.95e-0719811474ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYC DNAH10 EML6 PANX1 ACTN3 TNR

4.27e-0616511461703d3eb644b3c743ad3c5532b1d29ea010c79c8
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 SH3GL3 ZRANB3 RYR3 SCN3A SCN5A

8.22e-061851146bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

VWA8 TMOD3 ATP2C1 AARS2 DDX60L EIF4E2

8.48e-06186114674c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

VWA8 TMOD3 ATP2C1 AARS2 DDX60L EIF4E2

8.74e-061871146816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCellsystemic_lupus_erythematosus-flare-Myeloid-non-classical_monocyte-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TBXAS1 SCRN1 MS4A4A MYOF AIF1 DDX3Y

9.01e-0618811463e94d105ca96ceb5fdcca39a8050217913bc02da
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 EML6 TMEM132B RYR2 SCN2A SCN3A

1.14e-051961146676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 TMEM132B RYR2 SCN1A SCN2A SCN3A

1.21e-051981146c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 SLC1A3 MS4A4A MYOF AIF1 CRYBG3

1.25e-0519911467dde5c02fcae64cd2d68f607500f2a46b97851fd
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 SLC1A3 MS4A4A MYOF AIF1 CRYBG3

1.25e-05199114684879280851380e5bfe6bd48b6bbf57aedf6e003
ToppCellSepsis-URO-Lymphocyte-T/NK-CD4+_Tem|URO / Disease, condition lineage and cell class

MYC SYNE1 RPSA PDCD4 IQCA1 SCN2A

1.28e-0520011468b7bfe6411de9528603481f6e5612cbbb8471cf6
ToppCellmild-Non-classical_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBXAS1 MIS18BP1 SCRN1 MS4A4A MYOF AIF1

1.28e-052001146334bab6bf93d455f3526e817ea5785d8b6ee531c
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MBTD1 SLC1A3 HEPH VWA5A RUBCN

1.63e-051231145a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B0|367C / Donor, Lineage, Cell class and subclass (all cells)

VWA8 TMOD3 AARS2 DDX60L EIF4E2

4.09e-05149114541f28138bde45d0b814e116837e5a32b5e80d54a
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SH3GL3 EML6 SIK3 PITPNM3 CRYBG3

5.25e-051571145a426c54fd1545093d41426e9620862f71bd06f6b
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E FZD6 L3MBTL1 SCN3A SCN5A

7.03e-051671145b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E FZD6 L3MBTL1 SCN3A SCN5A

7.03e-051671145fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E FZD6 L3MBTL1 SCN3A SCN5A

7.03e-051671145f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1E FZD6 L3MBTL1 SCN3A SCN5A

7.03e-05167114526cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCellPND14-Immune-Immune_Myeloid-Dendritic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MIS18BP1 SAPCD2 ZRANB3 MAD1L1 AIF1

7.23e-0516811459b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MIS18BP1 SAPCD2 ZRANB3 MAD1L1 AIF1

7.23e-0516811454b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MIS18BP1 SAPCD2 ZRANB3 MAD1L1 AIF1

7.23e-051681145c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCellCOVID-19-Heart-CM_+_Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

TBXAS1 SLC1A3 RYR2 MS4A4A DDX60L

7.64e-0517011454232fe937909f93d3736988c707b8f95ce993398
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF26B SH3GL3 RYR3 FZD6 SCN3A

8.30e-0517311459dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCellSevere-CD4+_T_activated|Severe / Disease group and Cell class

MKRN1 BAG3 RYR2 PARP10 DDX60L

9.24e-051771145a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1|TCGA-Liver / Sample_Type by Project: Shred V9

RBMS2 MYOF ABI2 PITPNM3 KIF3C

9.49e-05178114551c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EML6 SCN2A SCN3A KIF3C GULP1

9.75e-051791145d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCelldroplet-Kidney-KIDNEY-1m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYC CACNA1E BTBD8 TMOD3 RYR2

1.03e-041811145d90faa6115b408c9fbca61fc90ff951e070754ba
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MBTD1 MIS18BP1 ILK NCLN TNR

1.05e-041821145d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EFHD2 MS4A4A MYOF AIF1 CRYBG3

1.05e-0418211459a68d3bd1cc9139de9e9e711c249d47ade826bb1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EFHD2 MS4A4A MYOF AIF1 CRYBG3

1.05e-041821145d57d18732aa6fb7b2d430601568f9ba525ac6e3c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EFHD2 MS4A4A MYOF AIF1 CRYBG3

1.05e-041821145c3fb1460160744144aa31afc76c0a4d42ebdeb91
ToppCell367C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.08e-041831145b12b89debc9dd6396188bc8fe44f54c01c560966
ToppCell367C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.08e-04183114519cc0009f5332b6e4d4274df123eebbfc80b669a
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 KIF26B RYR2 RYR3 SCN2A

1.11e-0418411452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 KIF26B RYR2 RYR3 SCN2A

1.11e-041841145ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 KIF26B RYR2 RYR3 SCN2A

1.11e-0418411452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

DNAH10 SYNE1 EFHD2 PPP4R3B RUBCN

1.11e-041841145791f1bcb954aadc63d4117c400537d036f68734d
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RTCB SLC1A3 MS4A4A MYOF RUBCN

1.20e-04187114572e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACC1 EFHD2 ACTN3 SLC1A3 MS4A4A

1.20e-0418711457b24a324335c30c4b37795c43611b297274c804b
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TBXAS1 SLC1A3 MS4A4A SCN5A AIF1

1.20e-04187114553d41c86f57c00e6148a3eb73f42a842d78d50a1
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRRN1 SYNE1 TMEM132B RYR2 MYOF

1.23e-0418811453177b2c1723268d330d3e9f24f9e24492ace6286
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

SIK3 BIRC6 ATP2C1 LRBA GOLGB1

1.23e-041881145ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MACC1 SH3GL3 TMOD3 FZD6 MYOF

1.23e-041881145eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRIN1 SLC1A6 SCN1A SCN2A PITPNM3

1.26e-041891145f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellmLN-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

MYC CAAP1 BAG3 ABI2

1.27e-041001144c560326f6ae5338aecdf11ef8adf04bc8769745c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF26B SLC1A3 RYR2 MAP3K5 MYOF

1.29e-04190114545df8fee00f8949937863159d7aa042e72748d9b
ToppCellfacs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E CABP5 SH3GL3 SCN3A SCN5A

1.32e-04191114548823a97c38263f2c6e58348214f5b62773a6368
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRRN1 KIF26B RYR2 MYOF IQCA1

1.32e-041911145156b467187331ac6ca390d6ca861d9670bb7b956
ToppCellfacs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E CABP5 SH3GL3 SCN3A SCN5A

1.32e-0419111450eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCellControl-PLT_1|World / Disease Group and Platelet Clusters

CABP5 VWA8 MKRN1 TMOD3 SWI5

1.35e-041921145f595eba81911eb860dce964f1d8269287f50d3ea
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF26B SLC1A3 RYR2 MYOF GULP1

1.35e-041921145deeecd26972241846b4cb998edf0c7a87ff0c4df
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 SCRN1 MS4A4A MYOF AIF1

1.35e-0419211457bcdbd97fa8c3bfccde426d44979601226913fc3
ToppCellnormal-na-Myeloid-non-classical_monocyte-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TBXAS1 MIS18BP1 MS4A4A AIF1 DDX3Y

1.39e-041931145053adc7ed9f997b503e12239a684bb9f5896e10c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPRIN1 SLC1A6 SCN1A SCN2A PITPNM3

1.39e-0419311455fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellhealthy_donor-Myeloid-Monocytic-CD16+_Monocyte|healthy_donor / Disease condition, Lineage, Cell class and subclass

TBXAS1 SCRN1 MS4A4A MYOF AIF1

1.42e-041941145ecf746ef1c5c4d6d9ca06a6d3e3778670b5700c2
ToppCellILEUM-inflamed-(3)_moDC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MIS18BP1 EFHD2 SLC1A3 MS4A4A AIF1

1.42e-041941145c9d2acab0bbcfa9a9113cf3b9f8147403f0beb43
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 SLC1A3 MS4A4A MYOF AIF1

1.45e-0419511454e9513a7ea69fa9fc8e9ff2da8ef3f44e8fdc70d
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TBXAS1 SLC1A3 MS4A4A MYOF AIF1

1.45e-041951145a25a342380e258b784227f7298f609ccaa1f9ce7
ToppCellMacrophages-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

TBXAS1 MIS18BP1 MS4A4A AIF1 DDX3Y

1.45e-0419511452af46e87947c16a7c2c367637e606cfbb8a78528
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYC RPSA SLC1A3 MS4A4A CTNNBL1

1.49e-0419611457ce416e1809bfbb39553c28c20125790100a938d
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SAPCD2 TMEM132B SCN1A SCN2A TNR

1.49e-041961145f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 SCRN1 MS4A4A MYOF AIF1

1.49e-04196114529246378ffb1010fe6858da756ae3d13df2306ba
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYC RPSA SLC1A3 MS4A4A CTNNBL1

1.49e-04196114580264c2fbd94418f981085fed7c5bdda1e6f404c
ToppCellILEUM-non-inflamed-(3)_moDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TBXAS1 MIS18BP1 SLC1A3 MS4A4A AIF1

1.49e-041961145e10f01172fd076d6892906853f9375d4c3058951
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SAPCD2 TMEM132B SCN1A SCN2A TNR

1.49e-041961145671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 EFHD2 MS4A4A MYOF AIF1

1.49e-04196114551fc8bb9a806f8fbf78d5d80d535f1068a9770c2
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYC RPSA SLC1A3 MS4A4A CTNNBL1

1.49e-041961145292da8a0c052917a2f68afee9068b5b8e1544b13
ToppCellBrain_organoid-organoid_Velasco_nature-6_mon-Neuronal-CPNs|6_mon / Sample Type, Dataset, Time_group, and Cell type.

SH3GL3 GPRIN1 SLC1A6 RYR2 SCN2A

1.49e-041961145c9e7ac34993c873de4f198cdae77dcf099731532
ToppCellILEUM-inflamed-(3)_MNP|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.53e-041971145b105bad5ac85961919a654a38587d1017973c981
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_other-Macro_interstitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLC1A3 MS4A4A DPEP3 AIF1 DDX60L

1.53e-0419711451a30747a2188a890f58d831030328986b3a4356d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.53e-041971145dc56bb758c7c5bd151be66f8f3b7078d085f72c7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.53e-0419711452efb5acd56b96e5afd8d72b927f1d53cc443766f
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNE1 EML6 RYR2 SCN1A SCN2A

1.56e-0419811458ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellwk_15-18-Hematologic-Myeloid-APOE+_Mac1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.56e-04198114588182ad964db88cf85b3e3a64929d07d59a923c2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBXAS1 EFHD2 MS4A4A DPEP3 AIF1

1.56e-04198114588635244a0b306d2cc50b8412fe47bb359c9cf00
ToppCellControl-PLT_4|Control / Disease Group and Platelet Clusters

MBTD1 MIS18BP1 BLZF1 PDCD4 RYR2

1.56e-041981145387fd3037fd52e4d4c42de0588767e58af228b59
ToppCellMonocytes|World / Immune cells in Kidney/Urine in Lupus Nephritis

TBXAS1 SLC1A3 MS4A4A MYOF AIF1

1.56e-0419811458beccf03c9ec9cd02a96107a9d7ca9a6764c6a61
ToppCellHealthy_donor-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

TBXAS1 SCRN1 MS4A4A MYOF AIF1

1.56e-0419811458a97c8b2a43e6d1e669ce18752841e2006744bd9
ToppCellHealthy_donor-Non-classical_Monocyte|Healthy_donor / disease group, cell group and cell class (v2)

TBXAS1 SCRN1 MS4A4A MYOF AIF1

1.56e-041981145d4eae333fa100db3ea2d4cbe7a1d6ab14816f0e2
ToppCellBAL-Mild-cDC_1|Mild / Compartment, Disease Groups and Clusters

RTCB PARP10 MS4A4A MYOF DDX60L

1.60e-041991145c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCellcellseq2-Immune-Immune_Myeloid-IM-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.60e-041991145372fb9eb90022dc4ac770a75b4e207c33d1d0c43
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 SAPCD2 SCN1A SCN2A TNR

1.60e-04199114519a97e27a4758e794ce7246d295e112b47931a48
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

VWA8 WDR70 SIK3 BIRC6 LRBA

1.60e-04199114594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellcellseq2-Immune-Immune_Myeloid-IM|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.60e-041991145dd3bf59cdc18091889cbf6c43f37100ba537843d
ToppCellcellseq2-Immune-Immune_Myeloid|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.60e-0419911456c3c9eceea20121ae17ae2462134aa0437f591b3
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SYNE1 SLC1A3 RYR2 MAP3K5 MYOF

1.60e-0419911458b86c69aaf60feff53aa782559cfece7342a23de
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 EFHD2 MS4A4A MYOF AIF1

1.60e-041991145fa5ad81554969fffe5e779614d071d9194a7182c
ToppCellParenchyma_Control_(B.)-Immune-TX-TRAM-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

MIS18BP1 BAG3 EFHD2 MS4A4A DDX60L

1.64e-0420011457c56935446f10d202eafa1f9ee7cb0aae4c2607e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TBXAS1 EFHD2 MS4A4A MYOF AIF1

1.64e-04200114552f2a97af2d77dd068b19531dad1b3fba2601e90
ToppCellLung_Parenchyma-Severe-Myeloid-MoAM-MoAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.64e-042001145baef622b82b262609cf5410f701ac814c20c3557
ToppCellLung_Parenchyma-Severe-Myeloid-MoAM-MoAM-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBXAS1 EFHD2 SLC1A3 MS4A4A AIF1

1.64e-0420011452e7478ddb2f09b0a14635759033c2e675b981c9f
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

SYNE1 SLC1A3 RYR3 MAP3K5 IQCA1

1.64e-042001145d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

SYNE1 SLC1A3 RYR3 MAP3K5 IQCA1

1.64e-042001145f861509b54185d89931db64da1b9d81986cc7938
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIF26B SCN1A SCN2A SCN3A TNR

1.64e-042001145f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIF26B SCN1A SCN2A SCN3A TNR

1.64e-042001145cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYNE1 SLC1A3 HEPH RYR3 IQCA1

1.64e-0420011457a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellmLN-Dendritic_cell-cDC2|Dendritic_cell / Region, Cell class and subclass

TBXAS1 MACC1 MS4A4A AIF1 DDX60L

1.64e-042001145e3f7852aaa26a9b3e626d85e40afde799e873045
DrugSC 38249

TBXAS1 RYR2 RYR3

4.37e-0741103CID000134834
DrugZonisamide

SCN1A SCN2A SCN3A SCN5A

1.17e-06171104DB00909
Drugbepridil

CACNA1E BIRC6 RYR2 RYR3 SBF1 SCN3A SCN5A

2.67e-061261107CID000002351
Drugo-vanillin

TNIP1 SCN5A CTNNBL1

1.76e-05111103CID000008991
DrugR 478

RYR2 RYR3 ATP2C1

1.76e-05111103CID000084223
Druglamotrigine

CACNA1E RYR2 RYR3 SCN2A SCN3A SCN5A

2.14e-051161106CID000003878
Drugriluzole

CACNA1E SLC1A3 RYR2 RYR3 SCN3A SCN5A CTNNBL1

2.22e-051741107CID000005070
DrugPhenytoin

SCN1A SCN5A

2.31e-0521102DB00252
Drugflecainide

RYR2 RYR3 GPD1L SCN3A SCN5A

2.43e-05711105CID000003355
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; PC3; HT_HG-U133A

KDM5A BLZF1 DDB1 PDCD4 KLHL22 MYOF ATP2C1

4.74e-0519611077142_DN
DrugAcetopromazine maleate salt [3598-37-6]; Down 200; 9uM; HL60; HG-U133A

PDCD4 MAP3K5 ARF6 ATP2C1 ABI2 MAD1L1 MMUT

4.90e-0519711071777_DN
DrugFipexide hydrochloride [34161-23-4]; Down 200; 9.4uM; HL60; HG-U133A

KDM5A SIK3 PDCD4 MAP3K5 ABI2 RUBCN PCNA

5.05e-0519811071560_DN
DrugRicinine [524-40-3]; Down 200; 24.4uM; MCF7; HT_HG-U133A

HDAC6 BLZF1 PDCD4 MAP3K5 ATP2C1 CTNNBL1 GOLGB1

5.39e-0520011076206_DN
DrugAspartic acid, N-acetyl (R,S) [997-55-7]; Up 200; 22.8uM; HL60; HT_HG-U133A

TBXAS1 TMOD3 PDCD4 ARF6 SRRT SBF1 IQCA1

5.39e-0520011071329_UP
Drug1,3-dioxane

TBXAS1 HDAC6 SYNE1

5.87e-05161103CID000010450
Drugbromfenacoum

BTBD8 RTCB BAG3 SCRN1 RPSA SIK3 PIP5K1C SLC1A3 ATP2C1 VWA5A TNR MMUT

6.66e-0564411012ctd:C013418
Drugcis-diammineplatinum(II

RYR2 RYR3

6.92e-0531102CID000159790
Drug2-hydroxyheptanoic acid

RYR2 RYR3

6.92e-0531102CID002750949
Drugchlorodibromomethane

MYC PCNA

6.92e-0531102ctd:C032707
Drug8N3-cADPR

RYR2 RYR3

6.92e-0531102CID000127713
Drugaminodantrolene

RYR2 RYR3

6.92e-0531102CID009570289
Drug2-hydroxycarbazole

RYR2 RYR3

6.92e-0531102CID000093551
DrugAC1L1TMU

TBXAS1 PCNA

6.92e-0531102CID000035398
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR2 RYR3

6.92e-0531102CID005748312
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A

3.25e-08101064DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A

3.25e-08101064DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN5A

7.62e-08121064DOID:0060170 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1E SLC1A3 SLC1A6 SBF1 SCN1A SCN2A SCN3A SCN5A

1.39e-071631068DOID:1826 (implicated_via_orthology)
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR2 RYR3

3.83e-0531062DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR2 RYR3

3.83e-0531062DOID:8545 (implicated_via_orthology)
DiseaseArrhythmogenic Right Ventricular Dysplasia

RYR2 SCN5A

3.83e-0531062C0349788
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A

6.60e-05221063DOID:2030 (implicated_via_orthology)
Diseaseepisodic ataxia type 6 (implicated_via_orthology)

SLC1A3 SLC1A6

1.90e-0461062DOID:0050994 (implicated_via_orthology)
DiseaseEpilepsy, Cryptogenic

ILK SLC1A3 SCN1A SCN2A

2.22e-04821064C0086237
DiseaseAwakening Epilepsy

ILK SLC1A3 SCN1A SCN2A

2.22e-04821064C0751111
DiseaseAura

ILK SLC1A3 SCN1A SCN2A

2.22e-04821064C0236018
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

2.65e-0471062C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

2.65e-0471062C0751057
DiseaseBrugada syndrome

GPD1L SCN5A

3.53e-0481062cv:C1142166
DiseaseFebrile Convulsions

SCN1A SCN2A

4.53e-0491062C0009952
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A

4.53e-0491062C3502809
DiseaseEpilepsy

ILK SLC1A3 SCN1A SCN2A

6.55e-041091064C0014544
DiseaseTachycardia, Ventricular

RYR2 SCN5A

6.88e-04111062C0042514
DiseaseLong QT Syndrome

RYR2 SCN5A

6.88e-04111062C0023976
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

9.72e-04131062C0751122
DiseaseSjogren's Syndrome

TNIP1 ITSN2

9.72e-04131062C1527336
DiseaseBrugada Syndrome 1

GPD1L SCN5A

9.72e-04131062C4551804
DiseaseSicca Syndrome

TNIP1 ITSN2

9.72e-04131062C0086981
DiseaseMMR-related febrile seizures

SCN1A SCN2A

1.30e-03151062EFO_0006519
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

1.48e-03161062C0393706
Diseaseacute lymphoblastic leukemia

KCNMB2 TBXAS1 RYR2

1.75e-03661063EFO_0000220
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

1.88e-03181062HP_0002373
Diseaseautism spectrum disorder (implicated_via_orthology)

KDM5A SCN1A SCN2A LRBA

2.24e-031521064DOID:0060041 (implicated_via_orthology)
DiseaseAdenocarcinoma of prostate

MYC MAD1L1

2.33e-03201062C0007112
Diseaseblood pressure

SYNE1 TNR

2.82e-03221062EFO_0004325
Diseaseosteoporosis (biomarker_via_orthology)

CSHL1 PCNA

2.82e-03221062DOID:11476 (biomarker_via_orthology)
Diseasedrug-induced liver injury

CAAP1 LRBA

3.35e-03241062EFO_0004228
DiseaseBrugada Syndrome (disorder)

GPD1L SCN5A

3.35e-03241062C1142166

Protein segments in the cluster

PeptideGeneStartEntry
DNELMEGKVQSGMGL

PRPF4B

121

Q13523
LEVGLEQQAELMLKM

BIRC6

2571

Q9NR09
LKGEGLQLMNLMLRE

CTNNBL1

331

Q8WYA6
MVIKMIDQGLILQDG

CACNA1E

1201

Q15878
IGKAEVMPVRLEMEN

CRYBG3

1726

Q68DQ2
KDLEEGIQMLMGRLE

CSHL1

146

Q14406
ILKILEGDNGMDSDM

CAAP1

191

Q9H8G2
EAMVMGILKQAFDVL

DIS3L2

771

Q8IYB7
LGSEDIDNQGLMMPK

BMS1

401

Q14692
LDGVMGRILELKNEM

IQCA1

76

Q86XH1
IALAMKMGLDGLQQD

ATP2C1

431

P98194
MAELQMLLEEEIPGG

ABI2

1

Q9NYB9
MDEQELEGMLKPFGQ

RBMS2

146

Q15434
KMPVQMIGDILAAEL

ITSN2

1281

Q9NZM3
MLEEAGEVLENMLKA

NCLN

1

Q969V3
GNVGMIMLIQVDVKL

OR9I1

41

Q8NGQ6
KAGEDRAILLGLAMM

KCNMB2

41

Q9Y691
EELGGQKQRADMLEM

MAD1L1

461

Q9Y6D9
ILKGMIDQISMKEAG

MIS18BP1

436

Q6P0N0
MKGALMEIIQLASLD

NELFA

71

Q9H3P2
GFRVGMKLEAVDLME

MBTD1

491

Q05BQ5
GVLQLGKMLTEKAME

BLZF1

61

Q9H2G9
KMGIDISVLMGANIA

GPD1L

141

Q8N335
MIVLKMVDLNGDDLG

ASAH2

281

Q9NR71
MIGKDDSMQNLGIIP

KIF26B

556

Q2KJY2
IDEFVGDMMKDLPIL

DDX60L

451

Q5H9U9
KLLAETAGMIGVQEM

CABP5

96

Q9NP86
NEMAELDIMGLALKL

FSIP2

5301

Q5CZC0
AMESKLLIGGRNIMD

KIF3C

516

O14782
MKLMDLDVEQLGIPE

PCNA

116

P12004
EMLRDLNLGEMKSGV

PDCD4

186

Q53EL6
LGFQVGMKLEAVDRM

L3MBTL1

411

Q9Y468
AIMEEQAAELLGVKM

EEF1AKMT1

171

Q8WVE0
NMIADLLVDMLGVLA

LRBA

146

P50851
VLKVMAIDMDEGINA

PCDHGB3

261

Q9Y5G1
KLGILPALEIVMGMD

PPP4R3B

361

Q5MIZ7
LLTNLGMIKMDVVDG

PANX1

366

Q96RD7
AKAQLEELMMVGDLL

KDM5A

1441

P29375
LVEDDFLMKVLEGMA

SBF1

411

O95248
MLLAMNKVEGDNISG

FZD6

341

O60353
QAMKDLDGMDADILG

FBF1

76

Q8TES7
RGMFAGGLKEMEQEE

KLHL22

76

Q53GT1
LIAGKIVEMEDMGVI

SLC1A3

296

P43003
LNMADMYGLEGLKEV

BTBD8

281

Q5XKL5
KLDEMQEGFKMGLTL

GULP1

276

Q9UBP9
SNMEIGMKVALEGLR

ILK

396

Q13418
LIAGKILEMEDMAVL

SLC1A6

321

P48664
NTMEALLLEMKIGAE

MACC1

281

Q6ZN28
LMGLDGMVLLLSVLE

MS4A4A

181

Q96JQ5
EGLNKEIMMELGRIS

ASNSD1

516

Q9NWL6
EMVAIGMKNGEFVIL

EML6

1741

Q6ZMW3
GEKVVEELNRLGMMI

DPEP3

251

Q9H4B8
AGRDGFIDLMELKLM

EFHD2

106

Q96C19
MKKLGQAMEEDLIVG

HDAC6

56

Q9UBN7
QAMEEDLIVGLQGMD

HDAC6

61

Q9UBN7
SDIDMGEIIMGNIEL

DDX3Y

181

O15523
GAAMEVEVLGMAIQK

GPRIN1

926

Q7Z2K8
LILAMLGEQFMVGEE

EIF4E2

151

O60573
LQAIMEMGAVAADKG

BAG3

521

O95817
MVTQLAKMLDALLEG

DNAH10

2316

Q8IVF4
AEAVAMGLLKQFEGM

RUBCN

626

Q92622
MNIPLGEKVMLDIVA

S100A7L2

1

Q5SY68
KEEEKLMIRGLGDIM

RYR2

2136

Q92736
FMLLLEKEEQMDGTV

DDB1

281

Q16531
LMLNGEEVEETELMG

DDB1

436

Q16531
MLRLKELGINNMGEL

LRRN1

286

Q6UXK5
KLAGQEGLVEMVLLM

PARP10

436

Q53GL7
EMLLMLLAAGGDDEL

MKRN1

446

Q9UHC7
GDRAKALDIMIPMVQ

MAP3K5

366

Q99683
MSGALDVLQMKEEDV

RPSA

1

P08865
IPMNAKDLEEALEMG

RTCB

161

Q9Y3I0
ALVMAQILKDMGITE

TAF9B

16

Q9HBM6
GNALIEVGESMKLMA

SH3GL3

111

Q99963
LLMKGEGEVKLNMAI

SYNE1

2671

Q8NF91
EGEGQGPLIKLEMMI

TMEM132B

751

Q14DG7
MEKILQMAEGIDIGE

NKRF

1

O15226
EAQGLMTAVGQMLDK

SPATA31A6

1201

Q5VVP1
GVDIPLKQLMVIGMD

PIWIL2

731

Q8TC59
ADQLEMVTELLGGDM

MYC

96

P01106
KDLDFMQDMPEGLLL

PIP5K1C

276

O60331
RDIEEGNVKMLGMQI

HEPH

1086

Q9BQS7
AQGLMTAVGQMLDEK

SPATA31A7

1206

Q8IWB4
VLGESGEMDALKIQM

SCN5A

1861

Q14524
NEDVLLAMEDMGLDK

SIK3

346

Q9Y2K2
LGESGEMDALRIQME

SCN3A

1861

Q9NY46
MFGDINLTLGMLNKE

MROH2B

11

Q7Z745
DMVELMLEEKGVQLD

AARS2

451

Q5JTZ9
TMLELEKQGLEAMEE

SCRN1

371

Q12765
LGESGEMDALRIQME

SCN1A

1876

P35498
IVKMLDAAVIKMEGG

SRRT

246

Q9BXP5
GAGKIGRMIAEEIME

ARNTL

491

O00327
SLEVMLMLVKAGADQ

ANKDD1B

146

A6NHY2
GNGDIDIMSLKRMLE

AIF1

61

P55008
AEEIVDGNLKMTLGM

ACTN3

126

Q08043
NKEMRILMLGLDAAG

ARF6

11

P62330
GIEMEKVMQELGKSL

C12orf4

171

Q9NQ89
GIKMLGELLEESQME

TNIP1

41

Q15025
AQGLMTAVGQMLDEK

SPATA31A3

1206

Q5VYP0
NDIKDVGQMLMGKLA

SWI5

201

Q1ZZU3
DLGNQLLGLKGVMEM

UNC45B

411

Q8IWX7
MEALGFLKLEVNGPM

TBXAS1

1

P24557
AQGLMTAVGQMLDEK

SPATA31A1

1206

Q5TZJ5
EQEKEVLLQGLEMMA

SAPCD2

236

Q86UD0
AQGLMTAVGQMLDEK

SPATA31A5

1206

Q5VU36
RMGKEEELLMINGLG

RYR3

2031

Q15413
MVGKPVNFMEEDILG

WDR70

126

Q9NW82
LGESGEMDALRIQME

SCN2A

1866

Q99250
MGADGETVVLKNMLI

TNR

1

Q92752
EGLIFLMMLQKGGEE

TRAV34

61

A0A0B4J273
AKILGMSLEEIMAAQ

VWA5A

701

O00534
LGMDVCGIDLLMKDD

RIMKLB

256

Q9ULI2
EMAEGKNAILIGMSQ

PITPNM3

41

Q9BZ71
VIVMEDMLKDFLLGE

VWA8

761

A3KMH1
SKVGELNEQLGMLME

TBC1D2B

431

Q9UPU7
ALDLLAGGMMPEEVK

ZNF318

2126

Q5VUA4
QLGTAVELEMAKMLE

TMOD3

296

Q9NYL9
MVADEMGLGKTIQAI

ZRANB3

56

Q5FWF4
EVLDQKEMKQMEGEG

GOLGB1

591

Q14789
AALKLINEIEEMGGM

MMUT

441

P22033
INEIEEMGGMAKAVA

MMUT

446

P22033
VMAGKVEMTLEILNE

MYOF

1961

Q9NZM1