Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSpectrin

SPTAN1 SPTBN5 SYNE3

3.59e-04231143PF00435
DomainDynamin_central

DNM1L MX1

5.45e-0461142IPR000375
DomainGOLGA6L

GOLGA6L4 GOLGA6L19

5.45e-0461142IPR026737
DomainGED

DNM1L MX1

5.45e-0461142SM00302
DomainDynamin_M

DNM1L MX1

5.45e-0461142PF01031
DomainGED_dom

DNM1L MX1

5.45e-0461142IPR020850
DomainGED

DNM1L MX1

5.45e-0461142PS51388
DomainDynamin_GTPase_CS

DNM1L MX1

5.45e-0461142IPR019762
DomainGED

DNM1L MX1

5.45e-0461142PF02212
DomainGED

DNM1L MX1

5.45e-0461142IPR003130
Domain-

ATP13A4 NT5C3A PITPNM1 TIMM50

6.31e-046411443.40.50.1000
DomainSpectrin_repeat

SPTAN1 SPTBN5 SYNE3

7.21e-04291143IPR002017
DomainG_DYNAMIN_1

DNM1L MX1

7.60e-0471142PS00410
DomainDYNc

DNM1L MX1

7.60e-0471142SM00053
DomainUbiquitin-rel_dom

FRMPD4 MYO7B DDI1 AXIN2 RAPGEF2 TBCE

9.32e-041841146IPR029071
DomainSPEC

SPTAN1 SPTBN5 SYNE3

9.66e-04321143SM00150
DomainSpectrin/alpha-actinin

SPTAN1 SPTBN5 SYNE3

9.66e-04321143IPR018159
DomainBTK

RASA3 BMX

1.29e-0391142SM00107
DomainZnf_Btk_motif

RASA3 BMX

1.29e-0391142IPR001562
DomainBTK

RASA3 BMX

1.29e-0391142PF00779
DomainZF_BTK

RASA3 BMX

1.29e-0391142PS51113
DomainHAD-like_dom

ATP13A4 NT5C3A PITPNM1 TIMM50

1.39e-03791144IPR023214
DomainMYB_LIKE

BDP1 CDC5L ZNF541

1.60e-03381143PS50090
DomainPDZ

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

1.74e-031411145PF00595
DomainPDZ

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

2.15e-031481145SM00228
Domain-

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

2.27e-0315011452.30.42.10
DomainPDZ

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

2.34e-031511145PS50106
Domain-

FAM120B MARF1

2.34e-031211423.40.50.1010
DomainPDZ

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

2.41e-031521145IPR001478
DomainG_DYNAMIN_dom

DNM1L MX1

3.20e-03141142IPR030381
DomainPIN_domain-like

FAM120B MARF1

3.20e-03141142IPR029060
DomainG_DYNAMIN_2

DNM1L MX1

3.20e-03141142PS51718
DomainWD40_repeat_CS

LRWD1 TBL3 UTP18 WDR11 WDR48

3.34e-031641145IPR019775
DomainSANT

BDP1 CDC5L ZNF541

3.52e-03501143SM00717
DomainDynamin_GTPase

DNM1L MX1

3.68e-03151142IPR001401
DomainDynamin_SF

DNM1L MX1

3.68e-03151142IPR022812
DomainDynamin_N

DNM1L MX1

3.68e-03151142PF00350
DomainGlyco_hormone_CN

CCN1 MUC5AC

3.68e-03151142IPR006208
DomainCys_knot

CCN1 MUC5AC

3.68e-03151142PF00007
DomainSANT/Myb

BDP1 CDC5L ZNF541

3.94e-03521143IPR001005
DomainGOLGA2L5

GOLGA6L4 GOLGA6L19

5.30e-03181142PF15070
DomainCTCK_1

CCN1 MUC5AC

5.30e-03181142PS01185
DomainGolgin_A

GOLGA6L4 GOLGA6L19

5.30e-03181142IPR024858
DomainP-loop_NTPase

DDX17 MYO7B SMC6 IFI44 MAGI3 DNM1L DDX51 AK9 TK2 RHOBTB2 KIFC3 MX1

5.62e-0384811412IPR027417
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

BDP1 DIP2B RASA3 UVSSA BARD1 MAGI3 BCR GMPS ZNF462 BPTF PPP4C WDR11 TBCK CSTF3 IGSF9 BOD1L1 NLGN2 RAPGEF2 KAT6B

3.75e-0714891141928611215
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MAGI3 RICTOR ZKSCAN5 ZNF462 PIKFYVE ALMS1 WDR11 SLITRK5 NLGN2 CDC5L EIF2AK1

7.20e-074931141115368895
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DIP2B SPTAN1 MAGI3 DNM1L RICTOR BCR BMX AKAP9 ALMS1 TIMM50 BOD1L1 RAPGEF2 PCDH7 KLC3

9.27e-078611141436931259
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

LIN7C SMC6 BARD1 DNM1L DDX51 URB2 GMPS PPP4C TIMM50 GABPB1

1.29e-064191141028700943
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FAM120B LRWD1 DDX17 RASA3 SPTAN1 RICTOR DDX51 URB2 TBL3 GTF3C5 GMPS UTP18 GRHPR WDR11 TIMM50 PRKDC CDC5L

2.04e-0613531141729467282
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

DDX17 ANK2 BZW2 MAGI3 DNM1L RICTOR GMPS SLITRK5 BOD1L1 PRKDC PCDH7 TBCE

3.84e-067081141239231216
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

DDX17 SPTAN1 DNM1L TBL3 GTF3C5 GMPS TIMM50 CSTF3 PRKDC CDC5L ZW10

8.48e-066381141133239621
Pubmed

Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa.

PDE6B CCN1

1.07e-052114224593181
Pubmed

Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells.

DNM1L MX1

1.07e-05211429422767
Pubmed

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

BPTF PRKDC

1.07e-052114228579392
Pubmed

BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor.

BCR CSF2RB

1.07e-052114218071309
Pubmed

Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells.

DUOX1 MUC5AC

1.07e-052114215640347
Pubmed

A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.

PPP4R1 PPP4C

1.07e-052114223084358
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

SPEG WDR11 IGSF9 BOD1L1 NLGN2 EIF2AK1

1.18e-05153114610718198
Pubmed

Loss of Anks6 leads to YAP deficiency and liver abnormalities.

HNF1B AXIN2 CCN1

2.70e-0518114332886109
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

SMC6 DNM1L TBL3 GTF3C5 GMPS MED15 BPTF PPP4C CSTF3 HTATSF1 BOD1L1 PRKDC CDC5L

2.92e-0510141141332416067
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

PPP4R1 SZT2 SMC6 DNM1L RICTOR SPAG7 HAUS3 TBL3 GMPS SNX14 SLC7A6OS EIF2AK1 TBCE GABPB1 WDR48

2.96e-0513271141532694731
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

SYNPO2 SPTAN1 HAUS3 PRKDC

3.05e-0554114435474131
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

DNM1L DDX51 TBL3 GTF3C5 GMPS MED15 BPTF CDC5L

3.14e-05370114822922362
Pubmed

Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression.

GOLPH3 WLS

3.19e-053114229990993
Pubmed

Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.

WLS AXIN2

3.19e-053114226245375
Pubmed

P. aeruginosa lipopolysaccharide-induced MUC5AC and CLCA3 expression is partly through Duox1 in vitro and in vivo.

DUOX1 MUC5AC

3.19e-053114223691121
Pubmed

Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine properties.

PRKDC MX1

3.19e-053114224307589
Pubmed

AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.

PPP4R1 PPP4C

3.19e-053114238424148
Pubmed

Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.

PPP4R1 PPP4C

3.19e-053114227507813
Pubmed

Wnt signaling regulates homeostasis of the periodontal ligament.

WLS AXIN2

3.19e-053114224410666
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

DDX17 SPTAN1 GTF3C5 MARF1 BOD1L1 PRKDC WDR48

3.34e-05272114731010829
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

RICTOR GOLPH3 GTF3C5 PPP4C SLITRK5 HTATSF1 NLGN2 RAPGEF2

3.65e-05378114834315543
Pubmed

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

SPTAN1 ANKRD36B SPTBN5 ALMS1 KIFC3 MUC5AC

3.67e-05187114626460568
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PPP4R1 BZW2 SPTAN1 RICTOR GMPS PPP4C AKAP9 WDR11 TIMM50 CSTF3 CDC5L PCDH7 WDR48

4.13e-0510491141327880917
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DDX17 SMC6 BARD1 DDX51 URB2 TBL3 GTF3C5 BPTF UTP18 PRKDC CDC5L

4.18e-057591141135915203
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

FRMPD4 ANK2 SPTAN1 MAGI3 SLITRK5 NLGN2

4.91e-05197114636604605
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ATP13A4 LIN7C HECTD3 BARD1 DDX51 URB2 TBL3 GTF3C5 MED15 ANKRD36B

4.95e-056381141031182584
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIP2B LRWD1 SPTAN1 RICTOR DDX51 PITPNM1 BPTF UTP18 PRKDC KAT6B PCDH7

4.98e-057741141115302935
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

DDX17 EFCAB6 SMC6 DNM1L RICTOR UTP18 WDR11 SLITRK5 PRKDC RAPGEF2 PCDH7

5.15e-057771141135844135
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PPP4R1 DIP2B HECTD3 RICTOR WLS BCR FREM2 WDR11 MARF1 WDR48

5.78e-056501141038777146
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRMPD4 SPEG CAMTA2 URB2 AKAP9 RHOBTB2 BOD1L1 WDR48

6.14e-05407114812693553
Pubmed

Epithelial Wntless regulates postnatal alveologenesis.

WLS AXIN2

6.36e-054114234931663
Pubmed

Activating Hair Follicle Stem Cells via R-spondin2 to Stimulate Hair Growth.

AXIN2 PRKDC

6.36e-054114227109869
Pubmed

Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.

PPP4R1 PPP4C

6.36e-054114215805470
Pubmed

Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.

WLS AXIN2

6.36e-054114225422448
Pubmed

DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.

GOLPH3 PRKDC

6.36e-054114224485452
Pubmed

mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.

RICTOR PRKDC

6.36e-054114216221682
Pubmed

Endothelial Wnts control mammary epithelial patterning via fibroblast signaling.

WLS AXIN2

6.36e-054114233789106
Pubmed

Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.

RASA3 PRKDC

6.36e-054114222773809
Pubmed

Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing.

WLS AXIN2

6.36e-054114234050174
Pubmed

Plasma membrane-cytoskeleton-endoplasmic reticulum complexes in neurons and astrocytes.

ANK2 SPTAN1

6.36e-054114214593108
Pubmed

Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.

PPP4R1 PPP4C

6.36e-054114210026142
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

LRWD1 DDX17 NT5C3A WLS TBL3 FBXL3 GTF3C5 GMPS PPP4C WDR11 TIMM50 PRKDC CDC5L WDR48

6.52e-0512571141437317656
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DDX17 SPTAN1 SMC6 DNM1L URB2 TBL3 GTF3C5 UTP18 TIMM50 CSTF3 PNPLA8 BOD1L1 PRKDC TDRD6 CDC5L

6.63e-0514251141530948266
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NR2C1 LRWD1 DDX17 BZW2 GMFG SPAG7 GMPS MED15 BPTF CSTF3 PRKDC ZW10 GABPB1

6.87e-0511031141334189442
Pubmed

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.

FREM2 TIMM50 PRKDC PCDH7

7.16e-0567114421875946
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

DDX17 SMC6 DNM1L GTF3C5 AXIN2 WDR11 TIMM50 HTATSF1 BOD1L1 PRKDC CDC5L

7.38e-058091141132129710
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

HECTD3 SOX30 BARD1 RICTOR GTF3C5 ALMS1 GRHPR CDC5L EIF2AK1 WDR48

7.43e-056701141022990118
Pubmed

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

DDX17 TBL3 WDR11 TIMM50 PRKDC CDC5L

7.97e-05215114630462309
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

DDX17 GMPS ZNF462 CSTF3 PRKDC CDC5L

9.04e-05220114635785414
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ZNF462 ALMS1 RHOBTB2 CDC5L KAT6B WDR48

1.02e-04225114612168954
Pubmed

Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor.

WLS AXIN2

1.06e-045114229874594
Pubmed

SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis.

DNM1L CASP10

1.06e-045114227799292
Pubmed

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.

PPP4R1 PPP4C

1.06e-045114218347064
Pubmed

Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis.

WLS AXIN2

1.06e-045114224315444
Pubmed

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

BPTF BOD1L1

1.06e-045114226626481
Pubmed

A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

ANK2 SPTAN1

1.06e-045114222632975
Pubmed

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells.

WLS AXIN2

1.06e-045114233399538
Pubmed

Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.

WLS AXIN2

1.06e-045114229787744
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

LRWD1 DDX17 SMC6 HAUS3 FBXL3 GTF3C5 CCN1 TIMM50 HTATSF1 PRKDC KIFC3 CDC5L ZW10

1.09e-0411551141320360068
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DDX17 BZW2 SMC6 GOLPH3 BCR GTF3C5 MED15 MARF1 EIF2AK1 ZW10 MUC5AC KLC3 TBCE WDR48

1.10e-0413211141427173435
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

DIP2B DDX17 SPTAN1 DNM1L BPTF BOD1L1 PRKDC

1.17e-04332114732786267
Pubmed

Defining the membrane proteome of NK cells.

DIP2B DDX17 BZW2 DNM1L DDX51 BCR MED15 SYNE3 WDR11 MARF1 PRKDC CDC5L ZW10

1.22e-0411681141319946888
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

PPP4R1 ANK2 SPTAN1 AKAP9 CDC5L

1.45e-04151114517043677
Pubmed

Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.

DDX17 AKAP9 TIMM50 PRKDC

1.57e-0482114430274258
Pubmed

Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit.

DNM1L BCR

1.58e-046114216999686
Pubmed

Chromophore supply modulates cone function and survival in retinitis pigmentosa mouse models.

PDE6B ALMS1

1.58e-046114237252956
Pubmed

In vivo assembly of the axon initial segment in motor neurons.

ANK2 SPTAN1

1.58e-046114223728480
Pubmed

LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.

AXIN2 BPTF

1.58e-046114230224759
Pubmed

Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development.

WLS AXIN2

1.58e-046114236931279
Pubmed

Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.

ANK2 SPTAN1

1.58e-046114216687515
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

LRWD1 GTF3C5 ZNF462 BPTF ALMS1 HTATSF1 BOD1L1 CDC5L

1.63e-04469114827634302
Pubmed

Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.

DDX17 TBL3 CSTF3 PRKDC CDC5L

1.84e-04159114522751105
Pubmed

Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.

ANK2 SPTAN1

2.21e-04711427495297
Pubmed

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells.

WLS AXIN2

2.21e-047114229420258
Pubmed

Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis.

WLS AXIN2

2.21e-047114233480845
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

DDX17 SPTAN1 BARD1 TBL3 GMPS BPTF ALMS1 CDC5L

2.31e-04494114826831064
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

NR2C1 DDX17 ANK2 DNM1L SPAG7 GMPS ALMS1 HTATSF1 BOD1L1 PRKDC CDC5L

2.57e-049341141133916271
Pubmed

Bridging expressed sequence alignments through targeted cDNA sequencing.

DIP2B SZT2

2.94e-048114215028280
Pubmed

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

PPP4R1 PPP4C

2.94e-048114218614045
Pubmed

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

PDE6B RICTOR

2.94e-048114225798619
Pubmed

Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity.

PDE6B MX1

2.94e-048114239047106
Pubmed

Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors.

PDE6B MX1

2.94e-048114236002185
Pubmed

Wnt signaling though beta-catenin is required for prostate lineage specification.

AXIN2 PRKDC

2.94e-048114222960283
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

DDX17 FRMPD4 BZW2 SPTAN1 ZNF462 TIMM50 PRKDC CDC5L

2.98e-04513114825798074
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

NR2C1 DDX17 SMC6 TBL3 BPTF MARF1 CSTF3 HTATSF1 BOD1L1 PRKDC CDC5L

3.08e-049541141136373674
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

DDX17 BZW2 UTP18 WDR11 TIMM50 CSTF3 PRKDC CDC5L ZW10

3.09e-04653114933742100
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

LRWD1 DDX17 LIN7C SPTAN1 DNM1L URB2 TBL3 GMPS TBC1D13 BPTF CCN1 BOD1L1 PRKDC

3.36e-0412971141333545068
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

ANK2 SPTAN1 DNM1L PITPNM1 RAPGEF2 PCDH7

3.39e-04281114628706196
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ANK2 HECTD3 SPTAN1 RICTOR TBL3 UTP18 SYNE3 AKAP9 WDR11 TIMM50 HTATSF1 PNPLA8 CDC5L PCDH7

3.70e-0414871141433957083
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DIP2B UVSSA NLGN2 WDR48

3.77e-04103114410819331
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

FRMPD4 ALMS1 RAPGEF2 KAT6B

3.91e-0410411449205841
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SPTAN1 GTF3C5 MED15 BPTF ALMS1 BOD1L1 PRKDC CDC5L

4.67e-04549114838280479
Pubmed

Cell organization, growth, and neural and cardiac development require αII-spectrin.

ANK2 SPTAN1

4.71e-0410114222159418
GeneFamilyWD repeat domain containing|UTPB complex

TBL3 UTP18

2.26e-0467121225
GeneFamilyEF-hand domain containing|Spectrins

SPTAN1 SPTBN5

3.15e-0477121113
GeneFamilyPDZ domain containing

SYNPO2 FRMPD4 LIN7C MAGI3 RAPGEF2

3.28e-041527151220
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

BDP1 CDC5L ZNF541

1.18e-0353713532
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#4_top-relative-expression-ranked_200

SYNPO2 COL19A1 PCDH7

2.35e-05111133gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200_k4
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#1

BDP1 NR2C1 EFCAB6 HAUS3 ZKSCAN5 GMPS AKAP9 ALMS1 PRKDC RAPGEF2 GABPB1

4.17e-0546911311Facebase_RNAseq_e8.5_Floor Plate_2500_K1
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

SPTAN1 RICTOR BCR MARF1 SLITRK5 HTATSF1 KAT6B

3.74e-071771147e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 DDX17 IFI44 BPTF AKAP9 BOD1L1 MX1

8.50e-07200114712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate|6m / Sample Type, Dataset, Time_group, and Cell type.

SYNPO2 COL19A1 BPTF AKAP9 CCN1 BOD1L1 PCDH7

8.50e-0720011477c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCellmetastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

LIN7C ANK2 FBXL3 CSF2RB SLC7A6OS C7

1.79e-0614211460e0f8bb956ff89dc98e8fa56f8acac33e01a26dd
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 FRMPD4 COL19A1 EFCAB6 MYO7B FREM2

7.97e-0618411462cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 FRMPD4 COL19A1 EFCAB6 MYO7B FREM2

7.97e-061841146ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP13A4 FRMPD4 COL19A1 EFCAB6 MYO7B FREM2

7.97e-0618411462b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

8.74e-0618711465df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

BDP1 MAGI3 RICTOR BPTF AKAP9 TBCK

1.02e-051921146916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.02e-05192114658c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 HKDC1 FREM2 DUOX1 RHOBTB2

1.02e-051921146cc9911e182a289779a2612bc213daae5607689e7
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

BDP1 MAGI3 RICTOR BPTF AKAP9 TBCK

1.05e-051931146e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.08e-05194114653f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.25e-051991146725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

BDP1 DDX17 IFI44 RICTOR BPTF AKAP9

1.25e-051991146f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.25e-0519911468587bd98de7767a575088afbea07a1feb4516b9b
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

NT5C3A SMC6 BPTF AKAP9 BOD1L1 PCDH7

1.25e-05199114618a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)|healthy_donor / Disease condition, Lineage, Cell class and subclass

SPEG IFI44 NLGN2 NEK11 MX1

2.83e-05138114597f5dc17522462133e582b508ad0ef036e656872
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

BPTF AKAP9 BOD1L1 PCDH7 WDR48

2.83e-051381145817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSSK6 GMFG CD163 CSF2RB IGSF9

4.64e-0515311454b999892fb797e9f0d391630094f466463299d57
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSSK6 GMFG CD163 CSF2RB IGSF9

4.64e-051531145e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSSK6 GMFG CD163 CSF2RB IGSF9

4.64e-051531145668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

FAM120B MYO7B IFI44 PTCHD4 MX1

5.09e-051561145f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

5.57e-051591145e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

URB2 C20orf96 CCN1 TBCK KIFC3

6.27e-05163114563b0badaee3b2d827b1f4524510e3384d8f8fcde
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

PDE6B FREM2 DUOX1 RHOBTB2 IGSF9

6.45e-05164114585f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

PDE6B FREM2 DUOX1 RHOBTB2 IGSF9

6.45e-051641145144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

SYNPO2 ANK2 SPEG CCN1 PCDH7

7.03e-051671145c4e321bb87512ea839f324c92c0f1afea891483f
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HNF1B HKDC1 ZKSCAN5 ALMS1 ZW10

7.23e-05168114508f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ATP13A4 HNF1B MAGI3 CCN1 RHOBTB2

8.76e-051751145bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

ELAPOR2 MAGI3 FREM2 DUOX1 RHOBTB2

1.00e-041801145198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1

1.08e-0418311456847c1252d6bb105524f812658112517fd351eab
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 HNF1B HKDC1 DUOX1 RHOBTB2

1.11e-0418411450ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.11e-041841145369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 HNF1B HKDC1 DUOX1 RHOBTB2

1.11e-0418411452a8338e94937686a148b5433515700ca0f674058
ToppCellIPF-Epithelial-ATII|IPF / Disease state, Lineage and Cell class

ELAPOR2 ATP13A4 FREM2 DUOX1 RHOBTB2

1.14e-041851145563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCellIPF-Epithelial-ATII|World / Disease state, Lineage and Cell class

ELAPOR2 ATP13A4 FREM2 DUOX1 RHOBTB2

1.17e-0418611456a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NT5C3A IFI44 CD163 NLGN2 MX1

1.20e-04187114572e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ELAPOR2 ATP13A4 HNF1B MAGI3 KIFC3

1.20e-04187114558d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

PPP4R1 ATP13A4 MAGI3 FREM2 DUOX1

1.23e-041881145707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ELAPOR2 ATP13A4 MAGI3 DUOX1 RHOBTB2

1.29e-04190114527a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

SYNPO2 ANK2 CCN1 C7 PCDH7

1.29e-0419011453a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

BARD1 DNM1L WDR11 TBCK TBCE

1.29e-0419011453f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 HNF1B MAGI3 FREM2

1.32e-04191114534cc997e4e5c727495f321e6807a84aa124da486
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1

1.32e-041911145a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.32e-041911145276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

ELAPOR2 ATP13A4 MAGI3 FREM2 DUOX1

1.32e-041911145e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellCOVID-19_Severe-B_intermediate|World / disease group, cell group and cell class

COL19A1 ANK2 MYO7B SMC6 MX1

1.32e-041911145f226fd69a26124ba98e4544f550b89a08e6a3708
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

DDX51 BPTF AKAP9 CCN1 BOD1L1

1.35e-0419211459cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.35e-04192114529f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellCOVID-19-Myeloid-MoAM1,_IL1R2|Myeloid / Condition, Lineage and Cell class

NT5C3A IFI44 CSF2RB RAPGEF2 MX1

1.35e-041921145be9d5685fa03563322f147a4b38ed31e4da59487
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ATP13A4 HNF1B ANK2 FREM2 MUC5AC

1.35e-041921145b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BARD1 DNM1L WDR11 TBCK TBCE

1.35e-041921145c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

PPP4R1 BDP1 COL19A1 CSF2RB SLITRK5

1.39e-04193114508696a99309f5b088692ddac8cca35413b5e810d
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ELAPOR2 MAGI3 FREM2 DUOX1 RHOBTB2

1.39e-041931145fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ELAPOR2 MAGI3 FREM2 DUOX1 RHOBTB2

1.39e-041931145f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ELAPOR2 HNF1B AXIN2 DUOX1 RHOBTB2

1.39e-04193114544839a606ae2f8e37421bda46d588189e1c943d2
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

COL19A1 MYO7B SMC6 PIKFYVE BPTF

1.42e-041941145ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BDP1 COL19A1 SMC6 PIKFYVE BOD1L1

1.45e-041951145481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

BDP1 COL19A1 SMC6 PIKFYVE BOD1L1

1.45e-0419511456108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ELAPOR2 HNF1B FREM2 DUOX1 RHOBTB2

1.49e-0419611457e5addaa844e66f8160e05858c341866a80aed23
ToppCelldistal-Epithelial-Alveolar_Epithelial_Type_1-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HNF1B MAGI3 CCN1 RHOBTB2 KLC3

1.49e-041961145b74dbdfc8d9b85d7cae5c6a49b56347b15ce16e1
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn|World / Primary Cells by Cluster

ANK2 SPTAN1 IFI44 ZNF462 AKAP9

1.49e-0419611459401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCelldistal-1-Epithelial-Alveolar_Epithelial_Type_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HNF1B MAGI3 CCN1 RHOBTB2 KLC3

1.53e-041971145d44b7dc7c6416ed9466889374c3ae39f43ac8bb6
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ELAPOR2 ATP13A4 MAGI3 AKAP9 KIFC3

1.53e-0419711453d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ELAPOR2 ATP13A4 FREM2 DUOX1 RHOBTB2

1.56e-041981145f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellCOVID-19_Mild-PLT_4|COVID-19_Mild / Disease Group and Platelet Clusters

NT5C3A GMFG GMPS AKAP9 CDC5L

1.56e-0419811453d8c33dba759df0974aeb2b9a6b5167ae7a18e1f
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TSSK6 SYNPO2 SPEG HAUS3 PCDH7

1.56e-041981145d1827e3707b929e3a3562989a0c11537d344e164
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

ANK2 IFI44 ZNF462 BPTF AKAP9

1.56e-041981145de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

ANKRD36B BPTF AKAP9 BOD1L1 PCDH7

1.60e-04199114561b1ed2db71b96157b92b7535d1955a4033098da
ToppCell356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 ANK2 CSF2RB CCN1 C7

1.60e-041991145f4fdf94c561dca35bb17766d908c5030655f43eb
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ATP13A4 MAGI3 FREM2 DUOX1 RHOBTB2

1.60e-0419911455cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellmedial-2-mesenchymal-Myofibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SYNPO2 ANK2 SPEG CCN1 GASK1A

1.60e-04199114595aae608fa35a9c82b12c6f18937ce636750ca44
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

ANK2 SPTAN1 BPTF AKAP9 SLITRK5

1.60e-0419911451b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ELAPOR2 ATP13A4 FREM2 DUOX1 RHOBTB2

1.60e-041991145a38a981cffa61c8444a980916de7414e689a1b63
ToppCellILEUM-inflamed-(8)_Fibroblasts|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SYNPO2 ANK2 CCN1 C7 PCDH7

1.60e-0419911453a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

ATP13A4 IFI44 CD163 DUOX1 MX1

1.60e-041991145155b03b859157013e9142e9248551369127d9204
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ELAPOR2 ATP13A4 FREM2 DUOX1 RHOBTB2

1.60e-0419911452dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellmedial-mesenchymal-Myofibroblast|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SYNPO2 ANK2 SPEG CCN1 GASK1A

1.60e-041991145e25acdb5809aaff631cb06dbe4c7e59549a0bdb9
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

ANK2 SPTAN1 BPTF AKAP9 SLITRK5

1.60e-0419911454bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellmedial-mesenchymal-Myofibroblast-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SYNPO2 ANK2 SPEG CCN1 GASK1A

1.60e-0419911459ebf4822ff9fa08574edec5dbf4f2a1488f34b1d
ToppCell356C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ELAPOR2 ANK2 CSF2RB CCN1 C7

1.60e-041991145c0fe99ed906d0eb99cccdab9a1fa32c17b3542e7
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

SMC6 BPTF AKAP9 BOD1L1 PCDH7

1.60e-041991145a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DDX17 ANK2 AKAP9 SLITRK5 C7

1.64e-0420011459b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellproximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ELAPOR2 DDC FREM2 DUOX1 RHOBTB2

1.64e-0420011457bd76884fcffdbd9b8d24f5b6b5187ad3963da5f
ToppCellsevere-B_intermediate|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

COL19A1 ANK2 SMC6 PIKFYVE RHOBTB2

1.64e-0420011456d0ac3d00400dd5657ee266f7b885381bf790ce1
ToppCellVE|World / Condition, Cell_class and T cell subcluster

DDX17 IFI44 BPTF BOD1L1 MX1

1.64e-0420011458ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

BDP1 ANK2 SPTAN1 AKAP9 SLITRK5

1.64e-042001145db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellproximal-Epithelial-Signaling_Alveolar_Epithelial_Type_2|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ELAPOR2 DDC FREM2 DUOX1 RHOBTB2

1.64e-042001145af57f837eb7f988d24fc4612d16d68121498f0b0
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

BDP1 ANK2 SPTAN1 AKAP9 SLITRK5

1.64e-04200114530a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCelldistal-Epithelial-Alveolar_Epithelial_Type_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ATP13A4 HNF1B MAGI3 CCN1 RHOBTB2

1.64e-042001145cbe3e107ac16c17687d73ebb04c39d51aba1fa98
ToppCellproximal-3-Epithelial-Signaling_Alveolar_Epithelial_Type_2|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ELAPOR2 DDC FREM2 DUOX1 RHOBTB2

1.64e-0420011459c7859659843b1566bdf623b269b5e166c89d38c
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital|World / Primary Cells by Cluster

BDP1 ANK2 SPTAN1 AKAP9 SLITRK5

1.64e-0420011456bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19|World / Primary Cells by Cluster

BDP1 ANK2 SPTAN1 AKAP9 SLITRK5

1.64e-042001145c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCellThalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--|Thalamus / BrainAtlas - Mouse McCarroll V32

GMFG CD163 CSF2RB MX1

1.90e-041111144a1b7940c6fa0e5a58aa4798b604469d79f33fa44
ToppCellThalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-|Thalamus / BrainAtlas - Mouse McCarroll V32

GMFG CD163 CSF2RB MX1

1.90e-041111144d1ec8e8e9adb11511b4ef363cc6f99286e2cc842
ToppCellThalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)|Thalamus / BrainAtlas - Mouse McCarroll V32

GMFG CD163 CSF2RB MX1

1.90e-041111144567e5ac2c78d45db207067f0f152bb24ed048c50
ToppCellThalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)|Thalamus / BrainAtlas - Mouse McCarroll V32

GMFG CD163 CSF2RB MX1

1.90e-041111144fd7aa25e83a0d762969e3966a658652da40c490e
ToppCellThalamus-Hematopoietic-MACROPHAGE|Thalamus / BrainAtlas - Mouse McCarroll V32

GMFG CD163 CSF2RB MX1

1.90e-041111144d48561078c387ac856c1c30e3d7a3e75ebde942e
DrugPhenazopyridine hydrochloride [136-40-3]; Down 200; 16uM; PC3; HT_HG-U133A

ZNF862 IFI44 BCR GTF3C5 PITPNM1 TK2 RHOBTB2 SLITRK5

5.17e-0619311285758_DN
DrugGly-His-Lys acetate salt; Down 200; 1uM; PC3; HT_HG-U133A

DDX17 SPEG SPTAN1 ZKSCAN5 AKAP9 TK2 SLITRK5 CDC5L

6.01e-0619711286570_DN
DrugResveratrol [501-36-0]; Up 200; 17.6uM; MCF7; HT_HG-U133A

DDX17 COL19A1 RASA3 SPEG SPTAN1 TK2 NEK11 MX1

6.47e-0619911285509_UP
Drug5186223; Up 200; 12uM; MCF7; HT_HG-U133A_EA

EFCAB6 RASA3 WLS AKAP9 ZW10 PCDH7 NEK11 GABPB1

6.71e-062001128885_UP
DiseaseGlobal developmental delay

FRMPD4 SZT2 DDC ZNF462 RHOBTB2

1.38e-041331095C0557874
Diseasecytochrome c oxidase assembly factor 3 homolog, mitochondrial measurement

PIKFYVE C7

3.73e-0481092EFO_0801513
DiseaseAdenocarcinoma of large intestine

AXIN2 TBCK PRKDC NEK11

4.51e-04961094C1319315
Diseasecytochrome c oxidase subunit 4 isoform 2, mitochondrial measurement

PIKFYVE C7

4.79e-0491092EFO_0801514
DiseaseRNA-binding protein 24 measurement

PIKFYVE C7

4.79e-0491092EFO_0802030
DiseaseDNA-directed RNA polymerases I and III subunit RPAC1 measurement

PIKFYVE C7

5.97e-04101092EFO_0801535
Diseaseguanylate-binding protein 6 measurement

PIKFYVE C7

7.28e-04111092EFO_0801662
Diseasegallbladder cancer (is_implicated_in)

RICTOR AXIN2

1.03e-03131092DOID:3121 (is_implicated_in)
Diseasevascular endothelial growth factor measurement

ATP13A4 ZNF462 CDC5L

1.18e-03561093EFO_0004762
DiseaseRomano-Ward Syndrome

ANK2 AKAP9

1.57e-03161092C0035828
DiseaseBenign neoplasm of stomach

CASP10 AXIN2

1.77e-03171092C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

CASP10 AXIN2

1.77e-03171092C0496905
Diseasealpha-L-iduronidase measurement

PDE6B UVSSA

1.77e-03171092EFO_0020139
DiseaseCarcinoma in situ of stomach

CASP10 AXIN2

1.77e-03171092C0154060
Diseaseblood metabolite measurement

GMPS ALMS1

2.22e-03191092EFO_0005664
Diseaselung cancer (is_implicated_in)

SOX30 RICTOR AXIN2

2.63e-03741093DOID:1324 (is_implicated_in)
DiseaseStomach Carcinoma

CASP10 AXIN2

2.71e-03211092C0699791
DiseaseParkinson's disease (implicated_via_orthology)

ATP13A4 DNM1L DDC AXIN2

2.78e-031571094DOID:14330 (implicated_via_orthology)
Diseaseprogression free survival, ovarian serous carcinoma

PTCHD4 PNPLA8

2.98e-03221092EFO_0004920, EFO_1001516
DiseaseBrugada Syndrome (disorder)

ANK2 AKAP9

3.54e-03241092C1142166

Protein segments in the cluster

PeptideGeneStartEntry
DDLPTVLKCARLVER

URB2

1416

Q14146
RIKNPTRVEEIICGL

NT5C3A

61

Q9H0P0
DPCIQTIDEIRRQIR

BHLHB9

286

Q6PI77
ELQERLSQECPIKEV

BZW2

261

Q9Y6E2
GREICLREKTPEVID

BDP1

906

A6H8Y1
EKEQVSLRCRELEII

AKAP9

986

Q99996
SAIPRRLECLKEDVQ

CDC5L

761

Q99459
RRKVCEQEEKYEIPE

BARD1

641

Q99728
IKRLEEPSLRCVELV

DNM1L

421

O00429
KVPYIVRQCVEEIER

BCR

1066

P11274
EIRRLICGPNTIDVE

ATP13A4

176

Q4VNC1
RCVEKVNLEEQTPVE

BMX

61

P51813
PECRLVKETRICEVR

CCN1

256

O00622
CSERVAELQRKPTRE

ALMS1

436

Q8TCU4
ARCLEELQRQEPSVE

CAMTA2

806

O94983
QLEEACRRLAEVSKP

AXIN2

696

Q9Y2T1
LCDREDRTPLIKAVQ

ANKRD36B

81

Q8N2N9
LVRQDPRFEICVEVI

DDC

391

P20711
RTREQDVEVLEPLKC

BPTF

1446

Q12830
DSVQCERKPIEVSRE

NR2C1

181

P13056
EVCREKQEAAVPLVR

RASA3

326

Q14644
CEIEVEEDGRKPVLR

KAT6B

1176

Q8WYB5
DVRLDQPQKRRVCEV

LRWD1

471

Q9UFC0
PEDLEKKRICRIITR

ANK2

1131

Q01484
VEVPEVIKDLCRRAS

DUOX1

941

Q9NRD9
KVLCEAESRVPVEEI

DDI1

31

Q8WTU0
REVIFEDVLLRRPKC

C20orf96

331

Q9NUD7
EPVRLERDICRAIEL

LIN7C

6

Q9NUP9
PVIEESLRVQICEKA

MAGI3

1146

Q5TCQ9
VVCEVDPELTEKLRK

GMFG

6

O60234
EREKLCRIVIIDDSL

FREM2

1956

Q5SZK8
PAKRQCIEIIENRVE

GABPB1

326

Q06547
TSERRIDREKLPQCQ

PCDH7

86

O60245
VKCDRDEIQLILPTR

PDE6B

456

P35913
EIFRRCKIPNTVEEA

CSTF3

641

Q12996
TCVVVAEERPRVALQ

DIP2B

1281

Q9P265
APVVCTRKRRLEDDE

MED15

656

Q96RN5
EAEIRECLEKVVPQA

NEK11

601

Q8NG66
REQEERLCEQEKLPG

GOLGA6L3

321

A6NEY3
LREQEERLCEQEKLP

GOLGA6L4

306

A6NEF3
ERLCEQEKLPGQERL

GOLGA6L4

311

A6NEF3
ERLCEQEKLPGQERL

GOLGA6L19

346

H0YKK7
EPLCQRALEIREKVL

KLC3

311

Q6P597
IIRSGEKICRRPEEI

MUC5AC

2146

P98088
EKICRRPEEITRLQC

MUC5AC

2151

P98088
NIIRSGEKICRRPEE

MUC5AC

3251

P98088
GEKICRRPEEITRLQ

MUC5AC

3256

P98088
NIIRSGEKICRRPEE

MUC5AC

4656

P98088
GEKICRRPEEITRLQ

MUC5AC

4661

P98088
RCREEEKVIPLEYLE

TK2

196

O00142
IITELCRNVRTPDLD

RICTOR

901

Q6R327
IEPKICREDLTDAIR

ELAPOR2

371

A8MWY0
PLVLNEIREDLRVEC

HTATSF1

281

O43719
VVREPADREQLCRAK

PCDHAC1

76

Q9H158
VKRQVERSEICTEEP

BOD1L1

676

Q8NFC6
REETKFTCIDPIVLQ

PIKFYVE

716

Q9Y2I7
VEERLREKCQNPAEL

GASK1A

451

Q9UFP1
LIRRVNEDLLEPVSC

CSF2RB

61

P32927
KGDLIEIERCEPVRS

IFI44

356

Q8TCB0
EIERCEPVRSKLEEV

IFI44

361

Q8TCB0
NRELECIREIKERVG

GMPS

221

P49915
AKERVRQDPCEDISR

EIF2AK1

131

Q9BQI3
RQDPCEDISRIQKIR

EIF2AK1

136

Q9BQI3
CRTLRELEIQVGEKV

EFCAB6

156

Q5THR3
VRDKTEESCPILRIE

COL19A1

26

Q14993
NCVRRNVTEDLVPIE

DDX51

186

Q8N8A6
PLDEELIRIAERCKN

FBXL3

346

Q9UKT7
APRERVIDLVRSCKE

FRMPD4

131

Q14CM0
DVCAQDERSKRILPL

C7

726

P10643
TTCRRLPEAIEEVKN

GRHPR

121

Q9UBQ7
KRVRQLLDLDPEVEC

GOLPH3

266

Q9H4A6
PSICDNQEILEERRL

HAUS3

246

Q68CZ6
CIPKRERTQDEIERT

MARF1

1246

Q9Y4F3
NCTKEEVERLLPTRQ

CASP10

96

Q92851
PQIRDLERGVEICIA

DDX17

286

Q92841
VEVEIQRLLGKVCDR

CD163

386

Q86VB7
VECLRRKPSRELVDQ

NLGN2

326

Q8NFZ4
EPEIQVRRLDTLLAC

FAM120B

686

Q96EK7
PSKEEREALVEECNR

HNF1B

256

P35680
RRTTDPKLCITRVEE

PNPLA8

371

Q9NP80
REEEFEQLTQVIRCP

SZT2

2326

Q5T011
CIRVEALPILEEQIA

AK9

56

Q5TCS8
NRLRLEEDKPAVERC

UTP18

76

Q9Y5J1
LEAAPEKDTVVRCLR

UVSSA

431

Q2YD98
RRDVCDIPLAIVDLK

TDRD6

1671

O60522
QELIERFDVETKVCP

PPP4R1

161

Q8TF05
RFDVETKVCPVLIEL

PPP4R1

166

Q8TF05
CVPVANKRDTRSIEE

SPAG7

191

O75391
ETEKICQLEPEGRVR

SYNE3

46

Q6ZMZ3
CQLEPEGRVRVDLVL

SYNE3

51

Q6ZMZ3
SRILQETVKELAPRC

HKDC1

871

Q2TB90
RRCEAELQELRTKPA

KIFC3

151

Q9BVG8
KEREEIECIEIQENP

PTCHD4

826

Q6ZW05
EDPLCADVILVLQER

RHOBTB2

261

Q9BYZ6
NRDPEEVKIICQRRS

SPTBN5

2326

Q9NRC6
VIKTEEPERLLEDCR

SOX30

211

O94993
PDVILCNSVELIRER

SLC7A6OS

161

Q96CW6
RQVIEKERPQLAECE

PITPNM1

876

O00562
IVRDCLEKDPIDRTD

RAPGEF2

106

Q9Y4G8
VKDISCLNRDPARVV

TIMM50

231

Q3ZCQ8
LRNPDIRVLICEEKA

WDR48

281

Q8TAF3
LPRVEVILDCSDRQK

SYNPO2

281

Q9UMS6
LLERIARKPTVCESE

SPEG

1681

Q15772
DEVSKQELCPRRLIS

SLITRK5

276

O94991
KERIPVFCIDVERND

SNX14

586

Q9Y5W7
KTLNKCEILPEERRR

TBCE

366

Q15813
IQAIRRDPEACEKLE

TBL3

686

Q12788
DPVRCNSLEEIKALR

SPTAN1

2116

Q13813
RQICPERIEVEKSAS

SMC6

851

Q96SB8
LQIDKDVRRLCPDIS

TBC1D13

121

Q9NVG8
PEIDIERCVRESINL

TBCK

686

Q8TEA7
LEVQELEPVTLRCVA

IGSF9

146

Q9P2J2
LVEFCREILPEKQAE

PRKDC

626

P78527
KREILEDVRNSPCVS

ZNF862

611

O60290
LKCENVLLSPDERRV

TSSK6

136

Q9BXA6
CKELPAEVVERSILE

ZNF462

216

Q96JM2
VCTNPVDRKVEEELR

GTF3C5

241

Q9Y5Q8
CDKIRDIEEAIPREI

WLS

71

Q5T9L3
AKVRLNPEECADVLR

WDR11

1096

Q9BZH6
IEQLRRCELIKESEV

PPP4C

11

P60510
ELEERRQQIVACPDV

ZKSCAN5

131

Q9Y2L8
REPEEVERTEEKVPC

ZNF541

1226

Q9H0D2
RLTRRVEEIKGEVCN

ZW10

26

O43264
LPIIEIRIVECRDDG

HECTD3

346

Q5T447
EEKVRPCIDLIDSLR

MX1

46

P20591
LLEKSRVCRQAPEER

MYO7B

236

Q6PIF6