Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of establishment of planar polarity involved in neural tube closure

VANGL2 DVL3 DVL1

6.24e-0715243GO:0090178
GeneOntologyBiologicalProcessestablishment of planar polarity involved in neural tube closure

VANGL2 DVL3 DVL1

7.67e-0716243GO:0090177
GeneOntologyBiologicalProcessestablishment of planar polarity of embryonic epithelium

VANGL2 DVL3 DVL1

1.12e-0618243GO:0042249
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

VANGL2 DVL3 DVL1

1.32e-0619243GO:0090175
GeneOntologyBiologicalProcessoutflow tract morphogenesis

VANGL2 DVL3 BMP4 DVL1

4.01e-0694244GO:0003151
GeneOntologyBiologicalProcessoutflow tract septum morphogenesis

VANGL2 DVL3 BMP4

4.45e-0628243GO:0003148
GeneOntologyBiologicalProcesscochlea morphogenesis

VANGL2 DVL3 DVL1

4.96e-0629243GO:0090103
GeneOntologyBiologicalProcessregulation of animal organ morphogenesis

VANGL2 DVL3 BMP4 DVL1

7.49e-06110244GO:2000027
GeneOntologyBiologicalProcessneural plate elongation

VANGL2 DVL1

7.77e-064242GO:0014022
GeneOntologyBiologicalProcessconvergent extension involved in neural plate elongation

VANGL2 DVL1

7.77e-064242GO:0022007
GeneOntologyBiologicalProcessneural tube closure

VANGL2 DVL3 BMP4 DVL1

8.34e-06113244GO:0001843
GeneOntologyBiologicalProcesstube closure

VANGL2 DVL3 BMP4 DVL1

8.64e-06114244GO:0060606
GeneOntologyBiologicalProcessprimary neural tube formation

VANGL2 DVL3 BMP4 DVL1

1.06e-05120244GO:0014020
GeneOntologyBiologicalProcessneural tube formation

VANGL2 DVL3 BMP4 DVL1

1.64e-05134244GO:0001841
GeneOntologyBiologicalProcessestablishment of planar polarity

VANGL2 DVL3 DVL1

1.78e-0544243GO:0001736
GeneOntologyBiologicalProcessestablishment of tissue polarity

VANGL2 DVL3 DVL1

1.90e-0545243GO:0007164
GeneOntologyBiologicalProcessmuscular septum morphogenesis

VANGL2 BMP4

1.94e-056242GO:0003150
GeneOntologyBiologicalProcessconvergent extension involved in organogenesis

VANGL2 DVL1

2.72e-057242GO:0060029
GeneOntologyBiologicalProcessheart morphogenesis

VANGL2 DVL3 BMP4 KAT6A DVL1

2.95e-05321245GO:0003007
GeneOntologyBiologicalProcessembryonic epithelial tube formation

VANGL2 DVL3 BMP4 DVL1

3.20e-05159244GO:0001838
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

VANGL2 DVL3 DVL1

3.49e-0555243GO:0060071
GeneOntologyBiologicalProcesspositive regulation of neuron projection arborization

DVL3 DVL1

3.62e-058242GO:0150012
GeneOntologyBiologicalProcessepithelial tube formation

VANGL2 DVL3 BMP4 DVL1

4.46e-05173244GO:0072175
GeneOntologyBiologicalProcessneural plate morphogenesis

VANGL2 DVL1

4.65e-059242GO:0001839
GeneOntologyBiologicalProcesscochlea development

VANGL2 DVL3 DVL1

4.77e-0561243GO:0090102
GeneOntologyBiologicalProcessmembranous septum morphogenesis

VANGL2 BMP4

5.81e-0510242GO:0003149
GeneOntologyBiologicalProcesstube formation

VANGL2 DVL3 BMP4 DVL1

6.03e-05187244GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

VANGL2 DVL3 BMP4 DVL1

6.42e-05190244GO:0016331
GeneOntologyBiologicalProcessconvergent extension involved in gastrulation

VANGL2 DVL1

7.09e-0511242GO:0060027
GeneOntologyBiologicalProcessneural tube development

VANGL2 DVL3 BMP4 DVL1

8.14e-05202244GO:0021915
GeneOntologyBiologicalProcessmorphogenesis of a polarized epithelium

VANGL2 DVL3 DVL1

8.16e-0573243GO:0001738
GeneOntologyBiologicalProcessnon-canonical Wnt signaling pathway

VANGL2 DVL3 DVL1

9.57e-0577243GO:0035567
GeneOntologyBiologicalProcesslateral sprouting from an epithelium

VANGL2 BMP4

1.00e-0413242GO:0060601
GeneOntologyBiologicalProcessneural plate development

VANGL2 DVL1

1.17e-0414242GO:0001840
GeneOntologyBiologicalProcessregulation of neuron projection arborization

DVL3 DVL1

1.35e-0415242GO:0150011
GeneOntologyBiologicalProcesscardiac septum morphogenesis

VANGL2 DVL3 BMP4

1.47e-0489243GO:0060411
GeneOntologyBiologicalProcessinner ear development

VANGL2 DVL3 BMP4 DVL1

1.94e-04253244GO:0048839
GeneOntologyBiologicalProcessspliceosomal complex assembly

RSRP1 LUC7L2 RBMX2

2.02e-0499243GO:0000245
GeneOntologyBiologicalProcessconvergent extension

VANGL2 DVL1

2.19e-0419242GO:0060026
GeneOntologyBiologicalProcessear development

VANGL2 DVL3 BMP4 DVL1

3.05e-04285244GO:0043583
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

VANGL2 BMP4 DRAXIN DVL1

3.66e-04299244GO:0060560
GeneOntologyBiologicalProcessmRNA processing

RSRP1 PNN SCAF8 LUC7L2 RBMX2

3.73e-04551245GO:0006397
GeneOntologyBiologicalProcessembryonic organ development

VANGL2 DVL3 BMP4 KAT6A DVL1

4.05e-04561245GO:0048568
GeneOntologyBiologicalProcessinner ear morphogenesis

VANGL2 DVL3 DVL1

4.39e-04129243GO:0042472
GeneOntologyBiologicalProcesscardiac septum development

VANGL2 DVL3 BMP4

4.91e-04134243GO:0003279
GeneOntologyBiologicalProcesssensory organ morphogenesis

VANGL2 DVL3 BMP4 DVL1

6.14e-04343244GO:0090596
GeneOntologyBiologicalProcessembryonic organ morphogenesis

VANGL2 DVL3 BMP4 DVL1

6.69e-04351244GO:0048562
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

RSRP1 PNN LUC7L2 RBMX2

7.20e-04358244GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RSRP1 PNN LUC7L2 RBMX2

7.20e-04358244GO:0000377
GeneOntologyBiologicalProcessear morphogenesis

VANGL2 DVL3 DVL1

7.36e-04154243GO:0042471
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

RSRP1 PNN LUC7L2 RBMX2

7.51e-04362244GO:0000375
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

VANGL2 DVL3 BMP4

8.38e-04161243GO:0003206
GeneOntologyBiologicalProcessneuron projection arborization

DVL3 DVL1

8.89e-0438242GO:0140058
GeneOntologyBiologicalProcessaxis elongation

VANGL2 BMP4

8.89e-0438242GO:0003401
GeneOntologyBiologicalProcessepithelial tube branching involved in lung morphogenesis

VANGL2 BMP4

1.03e-0341242GO:0060441
GeneOntologyBiologicalProcessregulation of vascular endothelial growth factor receptor signaling pathway

BMP4 MYOF

1.19e-0344242GO:0030947
GeneOntologyBiologicalProcessepithelial tube morphogenesis

VANGL2 DVL3 BMP4 DVL1

1.32e-03421244GO:0060562
GeneOntologyBiologicalProcessheart development

VANGL2 DVL3 BMP4 KAT6A DVL1

1.56e-03757245GO:0007507
GeneOntologyBiologicalProcesscardiac chamber development

VANGL2 DVL3 BMP4

1.85e-03212243GO:0003205
GeneOntologyBiologicalProcessgastrulation

VANGL2 BMP4 DVL1

1.85e-03212243GO:0007369
GeneOntologyBiologicalProcessventricular septum morphogenesis

VANGL2 BMP4

1.92e-0356242GO:0060412
GeneOntologyBiologicalProcessneuron projection morphogenesis

VANGL2 DVL3 RERE DRAXIN DVL1

2.01e-03802245GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

VANGL2 DVL3 RERE DRAXIN DVL1

2.21e-03819245GO:0120039
GeneOntologyBiologicalProcessendocrine pancreas development

BMP4 ZNF800

2.28e-0361242GO:0031018
GeneOntologyBiologicalProcesscell projection morphogenesis

VANGL2 DVL3 RERE DRAXIN DVL1

2.29e-03826245GO:0048858
GeneOntologyBiologicalProcessRNA splicing

RSRP1 PNN LUC7L2 RBMX2

2.50e-03502244GO:0008380
GeneOntologyBiologicalProcessprotein-RNA complex assembly

RSRP1 LUC7L2 RBMX2

2.75e-03244243GO:0022618
GeneOntologyBiologicalProcessWnt signaling pathway

VANGL2 DVL3 DRAXIN DVL1

2.76e-03516244GO:0016055
GeneOntologyBiologicalProcessvascular endothelial growth factor receptor signaling pathway

BMP4 MYOF

2.90e-0369242GO:0048010
GeneOntologyBiologicalProcessneuron projection development

VANGL2 DVL3 BMP4 RERE DRAXIN DVL1

2.94e-031285246GO:0031175
GeneOntologyBiologicalProcessprotein-RNA complex organization

RSRP1 LUC7L2 RBMX2

3.08e-03254243GO:0071826
GeneOntologyBiologicalProcessmorphogenesis of a branching structure

VANGL2 BMP4 RERE

3.22e-03258243GO:0001763
GeneOntologyBiologicalProcessheart looping

VANGL2 DVL1

3.24e-0373242GO:0001947
GeneOntologyBiologicalProcessmorphogenesis of an epithelial sheet

VANGL2 DVL1

3.33e-0374242GO:0002011
GeneOntologyCellularComponentWnt signalosome

DVL3 DVL1

1.63e-0416252GO:1990909
HumanPhenoFinger syndactyly

DVL3 BMP4 RERE KAT6A DVL1

6.91e-0621885HP:0006101
HumanPhenoCleft lip

VANGL2 DVL3 BMP4 RERE DVL1

1.11e-0524085HP:0410030
HumanPhenoAbnormal phalangeal joint morphology of the hand

DVL3 BMP4 RERE KAT6A DVL1

1.71e-0526285HP:0006261
HumanPhenoShort hard palate

BMP4 DVL1

2.15e-05582HP:0010290
HumanPhenoAnterior bulging of the globe

VANGL2 DVL3 BMP4 KAT6A DVL1

2.49e-0528385HP:0000644
HumanPhenoProptosis

VANGL2 DVL3 BMP4 KAT6A DVL1

2.49e-0528385HP:0000520
HumanPhenoMidface retrusion

DVL3 BMP4 RERE KAT6A DVL1

2.86e-0529185HP:0011800
HumanPhenoNaevus flammeus of the eyelid

DVL3 DVL1

4.52e-05782HP:0010733
HumanPhenoEuryblepharon

DVL3 DVL1

7.73e-05982HP:0012905
HumanPhenoRidged fingernail

DVL3 DVL1

7.73e-05982HP:0008402
HumanPhenoOnychogryposis of fingernail

DVL3 DVL1

7.73e-05982HP:0040036
HumanPhenoOpen bite

DVL3 BMP4 DVL1

8.77e-056183HP:0010807
HumanPhenoCraniofacial cleft

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

1.37e-0469486HP:5201015
HumanPhenoOrofacial cleft

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

1.37e-0469486HP:0000202
HumanPhenoSyndactyly

DVL3 BMP4 RERE KAT6A DVL1

1.63e-0441785HP:0001159
HumanPhenoAbnormal shape of the frontal region

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

2.00e-0474186HP:0011218
HumanPhenoAbnormal frontal bone morphology

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

2.02e-0474286HP:0430000
HumanPhenoAbnormality of the epiphysis of the femoral head

DVL3 BMP4 DVL1

2.20e-048383HP:0010574
HumanPhenoCurly eyelashes

DVL3 DVL1

2.24e-041582HP:0007665
HumanPhenoLow-set ears

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

2.33e-0476186HP:0000369
HumanPhenoAbnormal femoral epiphysis morphology

DVL3 BMP4 DVL1

2.45e-048683HP:0006499
HumanPhenoFingernail dysplasia

DVL3 DVL1

2.56e-041682HP:0100798
HumanPhenoBroad thumb

DVL3 RERE DVL1

2.80e-049083HP:0011304
HumanPhenoFlexion contracture of finger

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0005651
HumanPhenoCamptodactyly (hands)

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0010563
HumanPhenoCamptodactyly of toe

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0001836
HumanPhenoJoint contractures involving the joints of the feet

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0100492
HumanPhenoCamptodactyly of finger

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0100490
HumanPhenoFlexion contracture of toe

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0005830
HumanPhenoInterphalangeal joint contracture of finger

DVL3 BMP4 RERE DVL1

2.90e-0424084HP:0001220
HumanPhenoPosteriorly rotated ears

DVL3 BMP4 RERE KAT6A DVL1

2.90e-0447085HP:0000358
HumanPhenoToe joint contracture

DVL3 BMP4 RERE DVL1

2.94e-0424184HP:0034675
HumanPhenoAbnormal femoral head morphology

DVL3 BMP4 DVL1

2.99e-049283HP:0003368
HumanPhenoAbnormal lower limb epiphysis morphology

DVL3 BMP4 DVL1

3.19e-049483HP:0006500
HumanPhenoAbnormal lip morphology

VANGL2 DVL3 BMP4 MYOF RERE KAT6A DVL1

3.31e-04124987HP:0000159
HumanPhenoAnodontia

DVL3 DVL1

3.64e-041982HP:0000674
HumanPhenoFlexion contracture of finger

DVL3 BMP4 RERE DVL1

3.77e-0425784HP:0012785
HumanPhenoFinger joint contracture

DVL3 BMP4 RERE DVL1

3.89e-0425984HP:0034681
HumanPhenoFemoral hernia

DVL3 DVL1

4.04e-042082HP:0100541
HumanPhenoTriangular mouth

DVL3 DVL1

4.04e-042082HP:0000207
HumanPhenoAbnormal nail morphology

DVL3 BMP4 MYOF RERE DVL1

4.52e-0451685HP:0001597
HumanPhenoJoint contractures

DVL3 BMP4 RERE DVL1

6.16e-0429284HP:0001372
HumanPhenoBifid tongue

DVL3 DVL1

6.36e-042582HP:0010297
HumanPhenoJoint contracture of the hand

DVL3 BMP4 RERE DVL1

6.49e-0429684HP:0009473
HumanPhenoAnteverted nares

DVL3 BMP4 RERE KAT6A DVL1

6.60e-0455985HP:0000463
HumanPhenoUpturned nose

DVL3 BMP4 RERE KAT6A DVL1

6.60e-0455985HP:0000427
HumanPhenoPeg-shaped maxillary lateral incisors

BMP4 KAT6A

6.88e-042682HP:0006342
HumanPhenoShort phalanx of finger

DVL3 BMP4 RERE DVL1

7.37e-0430684HP:0009803
HumanPhenoAbnormal nostril morphology

DVL3 BMP4 RERE KAT6A DVL1

7.54e-0457585HP:0005288
HumanPhenoAbnormal location of ears

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

7.99e-0494586HP:0000357
HumanPhenoEpispadias

DVL3 DVL1

8.58e-042982HP:0000039
HumanPhenoOnychogryposis

DVL3 DVL1

8.58e-042982HP:0001805
HumanPhenoAplasia/Hypoplasia of the phalanges of the hand

DVL3 BMP4 RERE DVL1

8.64e-0431984HP:0009767
HumanPhenoAvascular necrosis of the capital femoral epiphysis

DVL3 DVL1

9.19e-043082HP:0005743
HumanPhenoAbnormal earlobe morphology

BMP4 RERE KAT6A

9.65e-0413783HP:0000363
HumanPhenoAbnormal limb epiphysis morphology

DVL3 BMP4 DVL1

9.86e-0413883HP:0006505
HumanPhenoDepressed nasal bridge

VANGL2 DVL3 BMP4 RERE DVL1

1.01e-0361285HP:0005280
HumanPhenoFlattened nasal bridge

VANGL2 DVL3 BMP4 RERE DVL1

1.01e-0361285HP:0000425
HumanPhenoEpicanthus

DVL3 BMP4 RERE KAT6A DVL1

1.03e-0361485HP:0000286
HumanPhenoFoot joint contracture

DVL3 BMP4 RERE DVL1

1.03e-0333484HP:0008366
HumanPhenoAbnormality of the tubular bones

DVL3 BMP4 RERE KAT6A DVL1

1.17e-0363285HP:0100713
HumanPhenoAbnormality of the long tubular bones

DVL3 BMP4 RERE KAT6A DVL1

1.17e-0363285HP:0100714
HumanPhenoCamptodactyly

DVL3 BMP4 RERE DVL1

1.18e-0334684HP:0012385
HumanPhenoClitoral hypoplasia

DVL3 DVL1

1.18e-033482HP:0000060
HumanPhenoAplasia/Hypoplasia of the clitoris

DVL3 DVL1

1.18e-033482HP:0040255
HumanPhenoRidged nail

DVL3 DVL1

1.18e-033482HP:0001807
HumanPhenoFoot polydactyly

BMP4 RERE DVL1

1.19e-0314783HP:0001829
HumanPhenoDuplication involving bones of the feet

BMP4 RERE DVL1

1.19e-0314783HP:0009136
HumanPhenoBroad phalanx

DVL3 RERE DVL1

1.21e-0314883HP:0006009
HumanPhenoBroad phalanges of the hand

DVL3 RERE DVL1

1.21e-0314883HP:0009768
HumanPhenoAbnormal morphology of the nasal alae

DVL3 BMP4 RERE KAT6A DVL1

1.24e-0363985HP:0000429
HumanPhenoHypoplastic labia minora

DVL3 DVL1

1.25e-033582HP:0000064
HumanPhenoAbnormal number of permanent teeth

DVL3 BMP4

1.25e-033582HP:0011044
HumanPhenoMesomelia

DVL3 DVL1

1.25e-033582HP:0003027
HumanPhenoAbnormal nasal bridge morphology

VANGL2 DVL3 BMP4 RERE KAT6A DVL1

1.29e-03102986HP:0000422
HumanPhenoAdrenal hypoplasia

VANGL2 BMP4

1.32e-033682HP:0000835
HumanPhenoBroad finger

DVL3 RERE DVL1

1.36e-0315483HP:0001500
HumanPhenoUpper-limb joint contracture

DVL3 BMP4 RERE DVL1

1.40e-0336284HP:0100360
HumanPhenoFlexion contracture of digit

DVL3 BMP4 RERE DVL1

1.40e-0336284HP:0030044
HumanPhenoHypoplastic labia majora

DVL3 DVL1

1.40e-033782HP:0000059
HumanPhenoDental malocclusion

DVL3 BMP4 DVL1

1.41e-0315683HP:0000689
HumanPhenoTooth agenesis

DVL3 BMP4 KAT6A DVL1

1.41e-0336384HP:0009804
HumanPhenoBroad long bones

DVL3 RERE DVL1

1.44e-0315783HP:0005622
HumanPhenoAgenesis of incisor

BMP4 KAT6A

1.48e-033882HP:0006485
HumanPhenoBrachydactyly

DVL3 BMP4 RERE KAT6A DVL1

1.54e-0367085HP:0001156
HumanPhenoAbnormal female external genitalia morphology

DVL3 RERE DVL1

1.54e-0316183HP:0000055
HumanPhenoCapillary hemangioma

DVL3 DVL1

1.55e-033982HP:0005306
HumanPhenoConical incisor

BMP4 KAT6A

1.55e-033982HP:0011065
HumanPhenoShort digit

DVL3 BMP4 RERE KAT6A DVL1

1.56e-0367285HP:0011927
HumanPhenoRetrognathia

DVL3 BMP4 KAT6A DVL1

1.59e-0337584HP:0000278
HumanPhenoAbnormal nail surface

DVL3 DVL1

1.63e-034082HP:0025757
HumanPhenoAbnormal labia minora morphology

DVL3 DVL1

1.72e-034182HP:0012880
HumanPhenoAbnormal tongue morphology

DVL3 BMP4 RERE DVL1

1.78e-0338684HP:0030809
HumanPhenoAbnormal antihelix morphology

RERE KAT6A

1.89e-034382HP:0009738
HumanPhenoJuvenile aseptic necrosis

DVL3 DVL1

1.89e-034382HP:0100323
HumanPhenoSpinal canal stenosis

BMP4 RERE

1.89e-034382HP:0003416
HumanPhenoAbnormal midface morphology

DVL3 BMP4 RERE KAT6A DVL1

1.94e-0370485HP:0000309
HumanPhenoPectus carinatum

DVL3 BMP4 DVL1

2.06e-0317883HP:0000768
HumanPhenoAbnormal labia majora morphology

DVL3 DVL1

2.07e-034582HP:0012881
MousePhenoabnormal heart and great artery attachment

VANGL2 DVL3 RERE PNN KAT6A

4.74e-06205185MP:0010426
MousePhenoabnormal heart and great vessel attachment

VANGL2 DVL3 RERE PNN KAT6A

5.09e-06208185MP:0010425
MousePhenoabnormal heart septum morphology

VANGL2 DVL3 BMP4 RERE PNN KAT6A

6.15e-06388186MP:0006113
MousePhenoventricular septal defect

VANGL2 BMP4 RERE PNN KAT6A

1.53e-05261185MP:0010402
MousePhenoabnormal right subclavian artery morphology

VANGL2 RERE KAT6A

1.72e-0540183MP:0010487
MousePhenoabnormal xiphoid process morphology

VANGL2 DVL3 BMP4

2.46e-0545183MP:0000159
MousePhenotransposition of great arteries

RERE PNN KAT6A

2.81e-0547183MP:0004110
MousePhenodouble outlet right ventricle

VANGL2 DVL3 RERE PNN

3.47e-05150184MP:0000284
MousePhenoabnormal subclavian artery morphology

VANGL2 RERE KAT6A

4.76e-0556183MP:0003395
MousePhenoabnormal interventricular septum morphology

VANGL2 BMP4 RERE PNN KAT6A

5.61e-05342185MP:0000281
MousePhenoabnormal truncus arteriosus septation

VANGL2 DVL3 PNN

1.60e-0484183MP:0010454
MousePhenosplit xiphoid process

DVL3 BMP4

1.86e-0416182MP:0004678
MousePhenoabnormal thoracic cage morphology

VANGL2 DVL3 BMP4 PNN KAT6A

2.34e-04463185MP:0004624
MousePhenoabnormal left subclavian artery morphology

VANGL2 RERE

2.37e-0418182MP:0010488
MousePhenoabnormal ventral body wall morphology

VANGL2 BMP4

3.24e-0421182MP:0003384
MousePhenoabnormal cardiovascular development

VANGL2 DVL3 BMP4 RERE PNN KAT6A

3.58e-04802186MP:0002925
MousePhenocleft palate

VANGL2 RERE PNN KAT6A

4.35e-04289184MP:0000111
MousePhenooral cleft

VANGL2 RERE PNN KAT6A

4.47e-04291184MP:0021164
MousePhenoabnormal aortic arch morphology

VANGL2 RERE KAT6A

4.47e-04119183MP:0004113
MousePhenoabnormal cardiac outflow tract development

VANGL2 DVL3 PNN

6.33e-04134183MP:0006126
MousePhenoabnormal thoracic aorta morphology

VANGL2 RERE KAT6A

6.33e-04134183MP:0010468
MousePhenoabnormal heart looping

VANGL2 BMP4 RERE

6.46e-04135183MP:0000269
MousePhenoabnormal palate morphology

VANGL2 RERE PNN KAT6A

6.47e-04321184MP:0003755
MousePhenolethality during fetal growth through weaning, complete penetrance

VANGL2 DVL3 BMP4 ZNF800 RERE PNN KAT6A

6.48e-041269187MP:0011111
MousePhenoabnormal facial morphology

VANGL2 DVL3 BMP4 RERE PNN KAT6A

7.05e-04910186MP:0003743
MousePhenosmall snout

VANGL2 DVL3 RERE

7.80e-04144183MP:0030190
MousePhenoaberrant origin of the right subclavian artery

VANGL2 KAT6A

8.08e-0433182MP:0010465
MousePhenoabnormal orientation of cochlear hair cell stereociliary bundles

VANGL2 DVL3

9.09e-0435182MP:0004522
MousePhenoabnormal somite size

VANGL2 RERE

9.61e-0436182MP:0005222
MousePhenoabnormal aortic arch and aortic arch branch attachment

VANGL2 KAT6A

1.02e-0337182MP:0010464
MousePhenoperinatal lethality, complete penetrance

VANGL2 BMP4 RERE PNN KAT6A

1.66e-03712185MP:0011089
MousePhenoabnormal vestibular hair cell morphology

VANGL2 BMP4

1.71e-0348182MP:0002623
MousePhenoabnormal primitive streak morphology

VANGL2 BMP4 PNN

2.04e-03201183MP:0002231
MousePhenoomphalocele

VANGL2 BMP4

2.08e-0353182MP:0003052
MousePhenoabnormal artery morphology

VANGL2 BMP4 RERE KAT6A

2.09e-03440184MP:0002191
MousePhenoabnormal head morphology

VANGL2 DVL3 BMP4 RERE PNN KAT6A

2.09e-031120186MP:0000432
MousePhenoabnormal somite shape

VANGL2 RERE

2.23e-0355182MP:0001691
MousePhenoabnormal organ of Corti morphology

VANGL2 DVL3 BMP4

2.28e-03209183MP:0000042
MousePhenodecreased rib number

VANGL2 BMP4

2.40e-0357182MP:0003345
MousePhenoabnormal hair cell morphology

VANGL2 DVL3 BMP4

2.44e-03214183MP:0000045
MousePhenoabnormal semicircular canal morphology

VANGL2 BMP4

2.57e-0359182MP:0002428
MousePhenoright aortic arch

VANGL2 RERE

2.65e-0360182MP:0004158
MousePhenoabnormal heart ventricle morphology

VANGL2 BMP4 RERE PNN KAT6A

2.67e-03793185MP:0005294
MousePhenoabnormal midbrain development

VANGL2 BMP4

2.74e-0361182MP:0003864
MousePhenosingle kidney

BMP4 RERE

2.74e-0361182MP:0003604
MousePhenoabnormal forebrain development

VANGL2 BMP4 RERE

2.81e-03225183MP:0003232
MousePhenoabnormal presacral vertebrae morphology

BMP4 PNN KAT6A

2.81e-03225183MP:0000459
MousePhenoabnormal aorta morphology

VANGL2 RERE KAT6A

2.81e-03225183MP:0000272
MousePhenoabnormal inner ear canal morphology

VANGL2 BMP4

2.92e-0363182MP:0002729
MousePhenoabnormal mechanoreceptor morphology

VANGL2 DVL3 BMP4

3.03e-03231183MP:0000972
MousePhenoabnormal gland development

BMP4 ZNF800 KAT6A

3.10e-03233183MP:0020973
MousePhenoabnormal ear development

VANGL2 BMP4

3.10e-0365182MP:0003938
MousePhenoabnormal cochlear labyrinth morphology

VANGL2 DVL3 BMP4

3.18e-03235183MP:0004426
MousePhenoabnormal scala media morphology

VANGL2 DVL3 BMP4

3.18e-03235183MP:0003169
MousePhenopersistent truncus arteriosus

DVL3 PNN

3.30e-0367182MP:0002633
MousePhenoabnormal aorticopulmonary septum morphology

DVL3 PNN

3.39e-0368182MP:0010650
MousePhenoaorticopulmonary septal defect

DVL3 PNN

3.39e-0368182MP:0010651
MousePhenomicrognathia

DVL3 KAT6A

3.39e-0368182MP:0002639
MousePhenoabnormal digestive system morphology

VANGL2 BMP4 ZNF800 RERE PNN KAT6A

3.41e-031233186MP:0000462
MousePhenoabnormal cochlea morphology

VANGL2 DVL3 BMP4

3.70e-03248183MP:0000031
MousePhenolimbs/digits/tail phenotype

VANGL2 BMP4 ST6GAL2 MYOF SNAPC4 KAT6A

3.78e-031258186MP:0005371
MousePhenoabnormal sternum morphology

VANGL2 DVL3 BMP4

4.00e-03255183MP:0000157
MousePhenoabnormal rib morphology

VANGL2 BMP4 PNN

4.09e-03257183MP:0000150
MousePhenoabnormal snout morphology

VANGL2 DVL3 RERE

4.09e-03257183MP:0000443
MousePhenoabnormal digestive system development

VANGL2 BMP4

4.11e-0375182MP:0003119
MousePhenoabnormal membranous labyrinth morphology

VANGL2 DVL3 BMP4

4.31e-03262183MP:0000035
MousePhenorib fusion

VANGL2 PNN

4.44e-0378182MP:0000154
MousePhenoabnormal appendicular skeleton morphology

VANGL2 DVL3 BMP4 ST6GAL2 SNAPC4

4.54e-03896185MP:0009250
MousePhenoabnormal vertebrae morphology

VANGL2 BMP4 PNN KAT6A

4.55e-03546184MP:0000137
MousePhenoabnormal inner ear vestibule morphology

VANGL2 BMP4

4.78e-0381182MP:0000034
MousePhenoabnormal abdominal wall morphology

VANGL2 BMP4

4.89e-0382182MP:0003257
MousePhenoatrioventricular septal defect

BMP4 KAT6A

5.13e-0384182MP:0010412
DomainDishevelled_protein_dom

DVL3 DVL1P1 DVL1

7.45e-094243IPR003351
DomainDishevelled

DVL3 DVL1P1 DVL1

7.45e-094243PF02377
DomainDishevelled_fam

DVL3 DVL1P1 DVL1

7.45e-094243IPR008339
DomainDIX

DVL3 DVL1P1 DVL1

6.50e-087243IPR001158
DomainDIX

DVL3 DVL1P1 DVL1

6.50e-087243PS50841
DomainDAX

DVL3 DVL1P1 DVL1

6.50e-087243SM00021
DomainDIX

DVL3 DVL1P1 DVL1

6.50e-087243PF00778
DomainDVL-1

DVL1P1 DVL1

1.58e-062242IPR008340
DomainDEP

DVL3 DVL1P1 DVL1

2.83e-0622243SM00049
DomainDEP

DVL3 DVL1P1 DVL1

2.83e-0622243PF00610
DomainDEP

DVL3 DVL1P1 DVL1

2.83e-0622243PS50186
DomainDEP_dom

DVL3 DVL1P1 DVL1

3.25e-0623243IPR000591
DomainDsh_C

DVL3 DVL1

4.74e-063242PF12316
DomainDishevelled_C-dom

DVL3 DVL1

4.74e-063242IPR024580
DomainDsh/Dvl-rel

DVL3 DVL1

9.48e-064242IPR015506
DomainPDZ

DVL3 DVL1P1 PDZD4 DVL1

2.94e-05141244PF00595
DomainPDZ

DVL3 DVL1P1 PDZD4 DVL1

3.56e-05148244SM00228
DomainPDZ

DVL3 DVL1P1 PDZD4 DVL1

3.85e-05151244PS50106
DomainPDZ

DVL3 DVL1P1 PDZD4 DVL1

3.95e-05152244IPR001478
DomainWHTH_DNA-bd_dom

DVL3 DVL1P1 KAT6A DVL1

2.38e-04242244IPR011991
Domain-

DVL3 PDZD4 DVL1

9.08e-041502432.30.42.10
DomainMyb_DNA-binding

RERE SNAPC4

9.18e-0435242PF00249
DomainMYB_LIKE

RERE SNAPC4

1.08e-0338242PS50090
DomainSANT

RERE SNAPC4

1.87e-0350242SM00717
DomainSANT/Myb

RERE SNAPC4

2.02e-0352242IPR001005
Domain-

DVL3 KAT6A DVL1

2.65e-032182431.10.10.10
DomainPHD

KAT6A RSF1

4.15e-0375242PF00628
DomainZnf_PHD-finger

KAT6A RSF1

4.59e-0379242IPR019787
DomainPHD

KAT6A RSF1

5.79e-0389242SM00249
DomainZnf_PHD

KAT6A RSF1

6.04e-0391242IPR001965
DomainZF_PHD_2

KAT6A RSF1

6.57e-0395242PS50016
DomainZF_PHD_1

KAT6A RSF1

6.70e-0396242PS01359
DomainZnf_FYVE_PHD

KAT6A RSF1

1.52e-02147242IPR011011
PathwayREACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_DVL_INTERACTING_PROTEINS

DVL3 DVL1

1.21e-055162M27447
PathwayKEGG_BASAL_CELL_CARCINOMA

DVL3 BMP4 DVL1

3.04e-0555163M17807
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL3 DVL1

3.37e-058162M27100
PathwayREACTOME_WNT_MEDIATED_ACTIVATION_OF_DVL

DVL3 DVL1

4.33e-059162MM14792
PathwayREACTOME_KILLING_MECHANISMS

DVL3 DVL1

7.92e-0512162M29844
PathwayREACTOME_PCP_CE_PATHWAY

VANGL2 DVL3 DVL1

1.42e-0492163M27322
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

DVL3 DVL1

1.44e-0416162M47823
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DVL3 BMP4 DVL1

1.66e-0497163MM15926
PathwayPID_BETA_CATENIN_DEG_PATHWAY

DVL3 DVL1

1.83e-0418162M31
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DVL3 BMP4 DVL1

1.87e-04101163M39448
PathwayPID_WNT_CANONICAL_PATHWAY

DVL3 DVL1

2.27e-0420162M90
PathwayWP_WNT_SIGNALING_PATHWAY

VANGL2 DVL3 DVL1

2.40e-04110163MM15977
PathwayWP_WNT_SIGNALING_WP428

VANGL2 DVL3 DVL1

2.60e-04113163M39669
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

DVL3 BMP4 DVL1

2.81e-04116163MM15863
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

DVL3 BMP4 DVL1

2.88e-04117163M39530
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL3 DVL1

5.51e-0431162M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL3 DVL1

5.51e-0431162MM15154
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

VANGL2 DVL3 DVL1

5.52e-04146163M27288
PathwayPID_WNT_NONCANONICAL_PATHWAY

DVL3 DVL1

5.87e-0432162M23
PathwayKEGG_WNT_SIGNALING_PATHWAY

VANGL2 DVL3 DVL1

6.09e-04151163M19428
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL3 DVL1

7.44e-0436162M39699
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL3 DVL1

7.86e-0437162M47411
PathwayBIOCARTA_ALK_PATHWAY

BMP4 DVL1

7.86e-0437162M17400
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL3 DVL1

1.11e-0344162MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL3 DVL1

1.16e-0345162M47412
PathwayWP_NOTCH_SIGNALING_WP268

DVL3 DVL1

1.16e-0345162M39571
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

DVL3 DVL1

1.21e-0346162M47409
PathwayWP_NOTCH_SIGNALING_PATHWAY

DVL3 DVL1

1.21e-0346162MM15971
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DVL3 DVL1

1.27e-0347162M7946
PathwayWP_WNT_SIGNALING_WP363

DVL3 DVL1

1.49e-0351162M39721
PathwayREACTOME_DEGRADATION_OF_DVL

DVL3 DVL1

1.73e-0355162MM15153
PathwayREACTOME_DEGRADATION_OF_DVL

DVL3 DVL1

1.86e-0357162M27399
PathwayWP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM

VANGL2 BMP4

2.06e-0360162M40048
PathwayWP_WNT_SIGNALING

DVL3 DVL1

2.13e-0361162MM15893
PathwayWP_JOUBERT_SYNDROME

DVL3 DVL1

3.28e-0376162M39835
PathwayREACTOME_PCP_CE_PATHWAY

DVL3 DVL1

4.08e-0385162MM15041
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

DVL3 DVL1

4.08e-0385162M48315
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

DVL3 DVL1

4.47e-0389162M39563
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

DVL3 DVL1

5.39e-0398162M39731
PathwayKEGG_PATHWAYS_IN_CANCER

DVL3 BMP4 DVL1

5.44e-03325163M12868
PathwayREACTOME_SIGNALING_BY_WNT

VANGL2 DVL3 DVL1

5.68e-03330163M7847
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

DVL3 DVL1

5.71e-03101162MM15829
PathwayKEGG_MELANOGENESIS

DVL3 DVL1

5.71e-03101162M7761
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

DVL3 DVL1

5.71e-03101162M39387
PathwayWP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT

DVL3 DVL1

6.74e-03110162M39492
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

DVL3 DVL1

8.37e-03123162MM14988
PathwayWP_ADIPOGENESIS

BMP4 DVL1

9.44e-03131162M39505
PathwayWP_ADIPOGENESIS_GENES

BMP4 DVL1

1.03e-02137162MM15970
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DVL3 DVL1

1.07e-02140162M27550
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

DVL3 DVL1

1.09e-02141162MM15266
PathwayWP_BREAST_CANCER_PATHWAY

DVL3 DVL1

1.29e-02154162M39739
PathwayWP_MRNA_PROCESSING

RSRC2 SCAF8 RBMX2

1.34e-02451163MM15946
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL3 DVL1

1.35e-02158162MM14791
Pubmed

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

DVL3 DVL1P1 DVL1

1.48e-0942638817329
Pubmed

Human dishevelled genes constitute a DHR-containing multigene family.

DVL3 DVL1P1 DVL1

1.48e-0942639192851
Pubmed

Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.

VANGL2 DVL3 DVL1

3.70e-09526315456783
Pubmed

Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.

VANGL2 DVL3 DVL1

1.30e-08726319008950
Pubmed

Expression of planar cell polarity genes during development of the mouse CNS.

VANGL2 DVL3 DVL1

3.11e-08926316487141
Pubmed

Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.

VANGL2 DVL3 DVL1

4.43e-081026315637299
Pubmed

Microtubules enable the planar cell polarity of airway cilia.

VANGL2 DVL3 DVL1

8.12e-081226323122850
Pubmed

The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.

VANGL2 DVL3 DVL1

2.06e-071626322771245
Pubmed

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.

VANGL2 DVL3 DVL1

3.00e-071826319701191
Pubmed

Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction.

VANGL2 DVL1

5.37e-07226212490194
Pubmed

cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.

DVL3 DVL1

5.37e-0722629344861
Pubmed

Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.

DVL1P1 DVL1

5.37e-0722628644734
Pubmed

DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.

DVL3 DVL1

5.37e-07226226924530
Pubmed

DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.

DVL3 DVL1

5.37e-07226235589804
Pubmed

Expression of dishevelled gene in Hirschsprung's disease.

DVL3 DVL1

5.37e-07226224040443
Pubmed

Atmin mediates kidney morphogenesis by modulating Wnt signaling.

VANGL2 DVL3 DVL1

7.43e-072426324852369
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

VANGL2 DVL3 PNN PDZD4 DVL1

1.38e-0626326534702444
Pubmed

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

VANGL2 DVL3 DVL1

1.49e-063026324302887
Pubmed

Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.

DVL3 DVL1

1.61e-06326221092292
Pubmed

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.

DVL3 DVL1

1.61e-06326215748172
Pubmed

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.

DVL3 DVL1

1.61e-06326218093802
Pubmed

Genomic organization of mouse Dishevelled genes.

DVL3 DVL1

1.61e-0632628973355
Pubmed

Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.

DVL3 DVL1

1.61e-06326218692936
Pubmed

DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.

DVL3 DVL1

1.61e-06326232900645
Pubmed

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.

VANGL2 DVL1

1.61e-06326216116426
Pubmed

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

DVL3 DVL1

1.61e-06326227744318
Pubmed

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

DVL3 DVL1

1.61e-06326227086035
Pubmed

Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.

DVL3 DVL1

1.61e-06326226359454
Pubmed

Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.

DVL3 DVL1

1.61e-06326223437169
Pubmed

Autosomal Dominant Robinow Syndrome

DVL3 DVL1

1.61e-06326225577943
Pubmed

Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.

VANGL2 DVL3 DVL1

1.81e-063226323177622
Pubmed

SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.

VANGL2 DVL3 DVL1

2.39e-063526339366759
Pubmed

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.

VANGL2 DVL3 DVL1

2.39e-063526332907846
Pubmed

Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.

DVL3 DVL1

3.22e-06426224643799
Pubmed

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.

DVL3 DVL1

3.22e-06426225557784
Pubmed

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

DVL3 DVL1

3.22e-06426211113207
Pubmed

Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.

DVL3 DVL1

3.22e-06426217593335
Pubmed

Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination.

VANGL2 DVL1

3.22e-06426228481871
Pubmed

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

DVL3 DVL1

3.22e-06426219625296
Pubmed

Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.

DVL1P1 DVL1

3.22e-06426220639201
Pubmed

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.

VANGL2 DVL1

3.22e-06426216571627
Pubmed

Clinical and molecular characterization of four patients with Robinow syndrome from different families.

DVL3 DVL1

3.22e-06426233496066
Pubmed

Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.

DVL3 DVL1

3.22e-06426225043421
Pubmed

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.

DVL3 DVL1

3.22e-06426219465938
Pubmed

Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.

DVL3 DVL1

3.22e-06426223371553
Pubmed

Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.

DVL3 DVL1

3.22e-06426218772438
Pubmed

ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.

NKTR PNN RBMX2 KAT6A RSF1

4.17e-0633026533301849
Pubmed

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

DVL3 DVL1

5.37e-06526225424568
Pubmed

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

DVL3 DVL1

5.37e-06526224469800
Pubmed

The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.

DVL3 DVL1

5.37e-06526222826439
Pubmed

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.

DVL3 DVL1

5.37e-06526220227366
Pubmed

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.

DVL3 DVL1

5.37e-06526210330181
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

VANGL2 DVL3 DVL1

5.88e-064726333141892
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

VANGL2 DVL3 DVL1P1 DVL1

6.11e-0616126436398662
Pubmed

Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations.

VANGL2 BMP4

8.05e-06626224689077
Pubmed

Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.

DVL3 DVL1

8.05e-06626232579954
Pubmed

Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

DVL3 DVL1

8.05e-06626234139860
Pubmed

Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.

DVL3 DVL1

8.05e-06626221880741
Pubmed

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.

DVL3 DVL1

8.05e-06626220439735
Pubmed

Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.

DVL3 DVL1

1.13e-05726210806215
Pubmed

Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.

VANGL2 RERE

1.13e-05726222510986
Pubmed

Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.

DVL3 DVL1

1.13e-05726217005174
Pubmed

Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.

VANGL2 DVL1

1.13e-05726222841628
Pubmed

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.

VANGL2 DVL1

1.50e-05826221718540
Pubmed

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).

DVL1P1 DVL1

1.50e-05826219643732
Pubmed

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

DVL3 DVL1

1.50e-05826215454084
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

DVL3 DVL1

1.50e-05826219388021
Pubmed

G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.

DVL3 DVL1

1.50e-05826218187455
Pubmed

Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.

DVL3 DVL1

1.50e-05826212165471
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MYOF RERE SNAPC4 PNN SCAF8 RBMX2

1.88e-0577426615302935
Pubmed

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.

DVL3 DVL1

1.93e-05926222899650
Pubmed

RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer.

DVL3 DVL1

1.93e-05926232965059
Pubmed

Prickle1 stunts limb growth through alteration of cell polarity and gene expression.

VANGL2 BMP4

1.93e-05926223913870
Pubmed

Regulation of the Wnt signaling pathway by disabled-2 (Dab2).

DVL3 DVL1

1.93e-05926212805222
Pubmed

Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

VANGL2 DVL3

1.93e-05926223095888
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

DVL3 BMP4 MYOF RSRC2 PNN LUC7L2 DVL1

2.71e-05124726727684187
Pubmed

Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.

NKTR PNN

2.94e-051126214729963
Pubmed

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.

DVL3 DVL1

2.94e-051126210644691
Pubmed

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

DVL3 DVL1

3.53e-051226212421720
Pubmed

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.

VANGL2 BMP4

3.53e-051226220962035
Pubmed

Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.

VANGL2 BMP4

3.53e-051226219706528
Pubmed

RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.

BMP4 RERE

3.53e-051226230061196
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

NKTR PNN LUC7L2 RBMX2

3.95e-0525926430404004
Pubmed

The Hippo pathway regulates Wnt/beta-catenin signaling.

DVL3 DVL1

4.17e-051326220412773
Pubmed

Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.

DVL3 DVL1

4.86e-051426212433684
Pubmed

Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects.

VANGL2 DVL1

5.61e-051526226883626
Pubmed

Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.

VANGL2 DVL3

7.26e-051726232805026
Pubmed

Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.

DVL3 DVL1

7.26e-051726220970343
Pubmed

Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance.

VANGL2 DVL1

7.26e-051726221316586
Pubmed

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.

DVL3 DVL1

8.16e-051826225073924
Pubmed

The Role of Sorting Nexin 17 in Cardiac Development.

VANGL2 DVL1

9.12e-051926234988124
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

C11orf98 ZNF800 RERE PNN LUC7L2

1.11e-0465526535819319
Pubmed

Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.

VANGL2 DVL1

1.12e-042126218701545
Pubmed

T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.

VANGL2 DVL3

1.12e-042126217119020
Pubmed

Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.

VANGL2 BMP4

1.12e-042126236026468
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

VANGL2 RERE RSRC2 LUC7L2 KAT6A RSF1

1.43e-04111626631753913
Pubmed

Regulation of planar cell polarity by Smurf ubiquitin ligases.

DVL3 DVL1

1.60e-042526219379695
Pubmed

Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.

BMP4 DVL1

2.47e-043126230254141
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

DVL3 RERE LUC7L2 DVL1

2.49e-0441826434709266
Pubmed

mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.

VANGL2 BMP4

2.97e-043426232866472
InteractionLUC7L interactions

VANGL2 NKTR PNN LUC7L2 PRM2 KAT6A

5.31e-07242266int:LUC7L
InteractionNKAP interactions

NKTR PNN LUC7L2 RBMX2 KAT6A

6.58e-07132265int:NKAP
InteractionSRPK1 interactions

RSRP1 BMP4 RSRC2 PNN LUC7L2 RBMX2 KAT6A

1.77e-06477267int:SRPK1
InteractionSRPK2 interactions

RSRP1 BMP4 NKTR RSRC2 PNN LUC7L2 RBMX2 KAT6A

2.18e-06717268int:SRPK2
InteractionNUP43 interactions

NKTR RERE PNN LUC7L2 RBMX2 RSF1 DVL1

1.05e-05625267int:NUP43
InteractionRNF151 interactions

DVL3 ZNF800 NKTR PNN

1.78e-05123264int:RNF151
InteractionCSNK2A1 interactions

DVL3 NKTR SNAPC4 PNN LUC7L2 KAT6A RSF1 DVL1

1.81e-05956268int:CSNK2A1
InteractionDHX8 interactions

NKTR RSRC2 PNN LUC7L2 RBMX2

3.16e-05292265int:DHX8
InteractionPNN interactions

VANGL2 NKTR PNN LUC7L2 RBMX2

3.71e-05302265int:PNN
InteractionC1orf35 interactions

DVL3 PNN LUC7L2 RBMX2 KAT6A

3.83e-05304265int:C1orf35
InteractionANKRD36B interactions

VANGL2 DVL3 SNAPC4

6.21e-0560263int:ANKRD36B
InteractionZNF593 interactions

LUC7L2 PRM2 KAT6A

6.53e-0561263int:ZNF593
InteractionVANGL2 interactions

VANGL2 DVL3 PNN DVL1

8.77e-05185264int:VANGL2
InteractionCLK2 interactions

RSRP1 NKTR PNN LUC7L2

1.08e-04195264int:CLK2
InteractionJMJD6 interactions

RSRC2 SCAF8 LUC7L2 RBMX2

1.30e-04205264int:JMJD6
InteractionSNRNP40 interactions

NKTR PNN SCAF8 KAT6A RSF1 DVL1

1.31e-04637266int:SNRNP40
InteractionZRSR2 interactions

DVL3 NKTR LUC7L2

1.31e-0477263int:ZRSR2
InteractionPSME3 interactions

DVL3 C11orf98 RSRP1 SNAPC4 PRM2

1.37e-04398265int:PSME3
InteractionSNIP1 interactions

DVL3 NKTR PNN LUC7L2 RBMX2

1.70e-04417265int:SNIP1
InteractionRNF43 interactions

VANGL2 DVL3 PNN PDZD4 DVL1

1.90e-04427265int:RNF43
InteractionVANGL1 interactions

VANGL2 DVL3 PNN DVL1

2.17e-04234264int:VANGL1
InteractionRPL22 interactions

VANGL2 BMP4 SNAPC4 LUC7L2 KAT6A

2.18e-04440265int:RPL22
InteractionNFKBIL1 interactions

VANGL2 SNAPC4 PNN

2.29e-0493263int:NFKBIL1
InteractionZBTB2 interactions

NKTR PNN RBMX2 KAT6A RSF1

2.42e-04450265int:ZBTB2
InteractionNUMA1 interactions

DVL3 PNN KAT6A RSF1 DVL1

2.93e-04469265int:NUMA1
InteractionRRP8 interactions

DVL3 ZNF800 RBMX2 KAT6A

3.19e-04259264int:RRP8
InteractionNKD1 interactions

DVL3 DVL1

3.31e-0421262int:NKD1
InteractionBRD3 interactions

VANGL2 RSRC2 PNN LUC7L2 RSF1

3.73e-04494265int:BRD3
InteractionKCNE3 interactions

VANGL2 DVL3 MYOF PNN

5.28e-04296264int:KCNE3
InteractionISY1 interactions

DVL3 PNN LUC7L2

6.83e-04135263int:ISY1
InteractionEPB41L4A interactions

VANGL2 DVL3 DVL1

7.59e-04140263int:EPB41L4A
InteractionHDHD2 interactions

LUC7L2 DVL1

7.75e-0432262int:HDHD2
CytobandEnsembl 112 genes in cytogenetic band chr1p36

RSRP1 RERE DRAXIN DVL1

5.53e-04681264chr1p36
GeneFamilyDishevelled segment polarity proteins|PDZ domain containing

DVL3 DVL1

4.40e-064162505
GeneFamilyPDZ domain containing

DVL3 PDZD4 DVL1

3.01e-041521631220
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

RERE SNAPC4

9.85e-0453162532
GeneFamilyPHD finger proteins

KAT6A RSF1

2.81e-039016288
GeneFamilyRNA binding motif containing

SCAF8 RBMX2

1.49e-02213162725
CoexpressionGSE19888_ADENOSINE_A3R_ACT_VS_TCELL_MEMBRANES_ACT_IN_MAST_CELL_DN

ZNF800 NKTR DRAXIN SCAF8

3.00e-05190254M7317
CoexpressionGSE45365_WT_VS_IFNAR_KO_CD8A_DC_MCMV_INFECTION_UP

DVL3 RERE LUC7L2 KAT6A

3.60e-05199254M9964
CoexpressionGSE12845_IGD_POS_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_DN

RSRP1 RSRC2 PNN RSF1

3.60e-05199254M3191
CoexpressionTABULA_MURIS_SENIS_PANCREAS_PANCREATIC_BETA_CELL_AGEING

RSRP1 NKTR RSRC2 LUC7L2

4.61e-05212254MM3816
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

NKTR RSRC2 PNN RSF1

4.94e-061972640fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RSRP1 NKTR PNN

8.41e-0514726394998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

RSRP1 NKTR KAT6A

1.12e-04162263b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DVL3 BMP4 DRAXIN

1.56e-041812634e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DVL3 BMP4 DRAXIN

1.56e-04181263ad30c01290fb98adbd0caed301a584761212c977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DVL3 BMP4 DRAXIN

1.56e-041812633a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCellcellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

C11orf98 DRAXIN PDZD4

1.58e-041822638ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DVL3 MYOF PDZD4

1.77e-04189263adbfc723130079b4caf551f66d2aee86fab1903c
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

RSRP1 NKTR PNN

1.85e-041922639cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR LUC7L2

1.85e-041922630dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR LUC7L2

1.88e-04193263471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR LUC7L2

1.88e-04193263fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR LUC7L2

1.91e-041942633a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR LUC7L2

1.91e-041942630b023de48ed8a550d169bbe954881eb04bf4f981
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR RERE

1.94e-041952637796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSRP1 NKTR RERE

1.94e-041952633e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RSRP1 NKTR PNN

1.97e-04196263a9157809122e6fc5783a291522f103bef30943e4
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

NKTR RSRC2 PNN

2.00e-041972635c33454b10023decd2f5ccda9229b6512659711e
ToppCellHealthy_donor|World / disease group, cell group and cell class (v2)

RSRP1 NKTR PNN

2.03e-041982631ed0b50c9754727a05c27b21f3546bf2e37eef7f
ToppCellmoderate-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

RSRP1 NKTR PNN

2.03e-041982630a868098b1ee4b28b2149ed766acb09e9c0ce14c
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

NKTR RSRC2 PNN

2.03e-0419826344417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NKTR RSRC2 PNN

2.03e-0419826328ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MYOF NKTR PNN

2.06e-041992633d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellHealthy/Control|World / Disease group and Cell class

RSRP1 NKTR PNN

2.06e-041992632623c42b3e79e401a485879b52e8bbcbc581544d
ToppCellhealthy_donor|World / Disease condition, Lineage, Cell class and subclass

RSRP1 NKTR PDZD4

2.09e-04200263afd4d5609adaa470e3d880f8be4a4d55e162b3d6
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NKTR RSRC2 PNN

2.09e-0420026312f1685ce8f218433068e090c9d839cd5a1910bf
ComputationalNeighborhood of DDX5

RSRP1 RSRC2 SCAF8

8.30e-0563153GNF2_DDX5
DrugNiclosamide [50-65-7]; Up 200; 12.2uM; HL60; HG-U133A

RSRP1 RERE SNAPC4 RSRC2 RSF1

8.78e-071722451998_UP
DrugCarbarsone [121-59-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A

DVL3 MYOF RERE KAT6A

4.66e-051932443250_UP
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

NKTR SNAPC4 KAT6A RSF1

4.75e-051942444309_DN
Drugthioridazine hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A

DVL3 MYOF SNAPC4 PNN

4.85e-051952445590_DN
DrugHaloperidol [52-86-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A

BMP4 MYOF RERE KAT6A

4.85e-051952441539_UP
DrugDydrogesterone [152-62-5]; Down 200; 12.8uM; PC3; HT_HG-U133A

NKTR RERE SNAPC4 PRM2

4.95e-051962444254_DN
Drug5-aminosalicylic acid; Down 200; 100uM; MCF7; HG-U133A

RSRP1 RERE SNAPC4 PNN

5.14e-05198244124_DN
DrugMoxalactam disodium salt [64953-12-4]; Down 200; 7uM; MCF7; HT_HG-U133A

DVL3 AEN NKTR RERE

5.14e-051982445609_DN
DrugAld1.1-H_000455; Down 200; 10uM; MCF7; HT_HG-U133A

DVL3 NKTR RERE RSF1

5.14e-051982447516_DN
Drugthioridazine hydrochloride; Down 200; 10uM; MCF7; HG-U133A

AEN SNAPC4 LUC7L2 RBMX2

5.35e-05200244417_DN
DrugThiram

VANGL2 DVL3 RSRC2 PNN KAT6A

2.03e-04533245ctd:D013893
DrugN-propanoylmannosamine

BMP4 ST6GAL2

6.20e-0435242CID000133240
DrugDigitoxigenin [143-62-4]; Up 200; 10.6uM; HL60; HT_HG-U133A

RSRP1 RSRC2 KAT6A

6.41e-041622431339_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

AEN SCAF8 LUC7L2

6.53e-041632437453_DN
DrugLanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A

RERE RSRC2 KAT6A

6.64e-041642433852_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

7.38e-041702433746_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

AEN SCAF8 LUC7L2

7.76e-041732435336_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

7.76e-041732434458_DN
DrugBeta-Escin [11072-93-8]; Up 200; 3.2uM; PC3; HT_HG-U133A

DVL3 RERE SNAPC4

7.89e-041742434544_UP
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

7.89e-041742437105_DN
Drug17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A

RSRP1 BMP4 RSRC2

7.89e-041742435215_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.02e-041752436316_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.02e-041752435935_DN
DrugCephaeline dihydrochloride heptahydrate [6487-30-5]; Up 200; 6uM; PC3; HT_HG-U133A

BMP4 SNAPC4 RSRC2

8.02e-041752434651_UP
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SNAPC4 SCAF8 LUC7L2

8.16e-041762431212_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.29e-041772437047_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.70e-041802435981_DN
DrugEllipticine [519-23-3]; Down 200; 16.2uM; PC3; HT_HG-U133A

MYOF AEN SCAF8

8.70e-041802435779_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.84e-041812437077_DN
DrugMycophenolic acid [24280-93-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

DVL3 AEN NKTR

8.84e-041812432857_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

AEN SCAF8 LUC7L2

8.84e-041812437005_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

8.99e-041822435802_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

AEN SCAF8 LUC7L2

9.27e-041842436939_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

9.42e-041852435882_DN
Drugcytochalasin B; Down 200; 20.8uM; MCF7; HT_HG-U133A_EA

NKTR SNAPC4 PNN

9.72e-041872431122_DN
DrugCiclopirox ethanolamine [41621-49-2]; Down 200; 15uM; MCF7; HT_HG-U133A

DVL3 MYOF KAT6A

9.72e-041872435023_DN
DrugEthotoin [86-35-1]; Down 200; 19.6uM; PC3; HT_HG-U133A

RSRP1 NKTR KAT6A

9.87e-041882434545_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

AEN NKTR GPR22

1.02e-031902432137_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Down 200; 13.6uM; PC3; HT_HG-U133A

DVL3 RERE SNAPC4

1.02e-031902434582_DN
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

NKTR RSRC2 KAT6A

1.02e-031902434322_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A

MYOF SCAF8 LUC7L2

1.03e-031912437503_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

NKTR RERE SNAPC4

1.03e-031912431057_DN
DrugGramine [87-52-5]; Up 200; 23uM; MCF7; HT_HG-U133A

MYOF GPR22 KAT6A

1.05e-031922432799_UP
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

AEN NKTR GPR22

1.05e-031922432666_DN
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; PC3; HT_HG-U133A

RSRP1 NKTR SNAPC4

1.05e-031922434268_DN
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

RSRP1 MYOF RERE

1.05e-031922433753_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A_EA

PNN LUC7L2 RBMX2

1.05e-031922431047_DN
Drugrosiglitazone; Down 200; 10uM; PC3; HT_HG-U133A

BMP4 MYOF SNAPC4

1.06e-031932431233_DN
Druggeldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A

DVL3 SNAPC4 KAT6A

1.06e-031932435588_DN
DrugHycanthone [3105-97-3]; Down 200; 11.2uM; PC3; HT_HG-U133A

MYOF SNAPC4 PRM2

1.06e-031932434630_DN
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A

MYOF RERE KAT6A

1.06e-031932433262_UP
DrugDibucaine [85-79-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

BMP4 MYOF KAT6A

1.08e-031942434149_DN
DrugIopanoic acid [96-83-3]; Down 200; 7uM; MCF7; HT_HG-U133A

BMP4 MYOF KAT6A

1.08e-031942433527_DN
DrugNifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A

MYOF RERE SNAPC4

1.08e-031942431814_UP
DrugTolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; PC3; HT_HG-U133A

SNAPC4 RBMX2 KAT6A

1.08e-031942434262_DN
DrugRacecadotril [81110-73-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

MYOF SNAPC4 RBMX2

1.08e-031942435755_DN
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

DVL3 BMP4 SNAPC4

1.08e-031942437354_DN
DrugCyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A

BMP4 RERE KAT6A

1.08e-031942434411_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; PC3; HT_HG-U133A

AEN SNAPC4 LUC7L2

1.08e-031942431209_DN
DrugChloramphenicol [56-75-7]; Down 200; 12.4uM; PC3; HT_HG-U133A

MYOF AEN KAT6A

1.08e-031942435047_DN
DrugEtifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

DVL3 MYOF NKTR

1.08e-031942432838_UP
DrugBenzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A

BMP4 AEN SNAPC4

1.08e-031942436070_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

MYOF AEN NKTR

1.10e-03195243999_DN
Drugphentolamine; Down 200; 11.5uM; MCF7; HT_HG-U133A_EA

RSRP1 NKTR PNN

1.10e-031952431138_DN
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

NKTR PNN RBMX2

1.10e-031952431080_DN
Drug2-propylpentanoic acid; Down 200; 200uM; PC3; HT_HG-U133A

MYOF AEN SCAF8

1.10e-031952431214_DN
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; HL60; HT_HG-U133A

RSRP1 AEN RBMX2

1.10e-031952432359_DN
DrugTiletamine hydrochloride; Down 200; 15.4uM; HL60; HT_HG-U133A

MYOF AEN SNAPC4

1.10e-031952433137_DN
DrugAH23848 hemicalcium salt hydrate; Up 200; 1uM; MCF7; HT_HG-U133A

MYOF RERE SNAPC4

1.10e-031952436903_UP
Drug5252917; Down 200; 14uM; MCF7; HT_HG-U133A_EA

RSRP1 BMP4 NKTR

1.10e-03195243944_DN
DrugIvermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A

MYOF SNAPC4 LUC7L2

1.11e-031962432051_DN
DrugRiluzole hydrochloride; Down 200; 14.8uM; MCF7; HT_HG-U133A

MYOF NKTR KAT6A

1.11e-031962434689_DN
DrugPramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; HL60; HT_HG-U133A

MYOF AEN GPR22

1.11e-031962432198_DN
DrugBetazole hydrochloride; Up 200; 27uM; PC3; HT_HG-U133A

MYOF SNAPC4 KAT6A

1.11e-031962436344_UP
DrugDinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

DVL3 MYOF KAT6A

1.11e-031962435409_DN
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

DVL3 MYOF RERE

1.11e-031962435226_UP
DrugPrilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; MCF7; HT_HG-U133A

DVL3 MYOF RERE

1.11e-031962432314_DN
Drugclozapine; Down 200; 10uM; PC3; HT_HG-U133A

BMP4 MYOF SNAPC4

1.11e-031962434453_DN
DrugTocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A

MYOF SNAPC4 KAT6A

1.11e-031962433256_UP
Drug(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A

NKTR RERE KAT6A

1.11e-031962433789_DN
DrugProguanil hydrochloride [637-32-1]; Down 200; 13.8uM; HL60; HT_HG-U133A

AEN RERE GPR22

1.11e-031962432944_DN
Drugdaunorubicin HCl; Up 200; 1uM; PC3; HT_HG-U133A

DVL3 BMP4 KAT6A

1.11e-031962437511_UP
DrugCefadroxil [50370-12-2]; Up 200; 11uM; MCF7; HT_HG-U133A

MYOF RERE KAT6A

1.11e-031962433259_UP
DrugPNU-0230031 [267429-39-0]; Up 200; 1uM; PC3; HT_HG-U133A

NKTR GPR22 KAT6A

1.11e-031962434291_UP
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; MCF7; HT_HG-U133A

MYOF NKTR RERE

1.11e-031962432249_DN
DrugDemecarium bromide [56-94-0]; Up 200; 5.6uM; MCF7; HT_HG-U133A

BMP4 MYOF RERE

1.11e-031962436269_UP
DrugGabazine [105538-73-6]; Up 200; 10.8uM; MCF7; HT_HG-U133A

MYOF NKTR KAT6A

1.11e-031962433253_UP
DrugAmikacin hydrate [37517-28-5]; Up 200; 6.6uM; PC3; HT_HG-U133A

RERE SNAPC4 PRM2

1.11e-031962436715_UP
DrugProstaglandin E1; Up 200; 10uM; MCF7; HT_HG-U133A

DVL3 MYOF NKTR

1.13e-031972436576_UP
DrugDAPH; Up 200; 10uM; MCF7; HG-U133A

DVL3 NKTR RBMX2

1.13e-03197243624_UP
DrugSulfathiazole [72-14-0]; Down 200; 15.6uM; PC3; HT_HG-U133A

MYOF NKTR RERE

1.13e-031972434183_DN
DrugNorcyclobenzaprine [303-50-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

AEN SNAPC4 RBMX2

1.13e-031972434190_DN
DrugOrphenadrine hydrochloride [341-69-5]; Down 200; 13uM; PC3; HT_HG-U133A

BMP4 RERE SNAPC4

1.13e-031972433801_DN
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A

BMP4 RERE SNAPC4

1.13e-031972433763_DN
DiseaseRobinow Syndrome

DVL3 DVL1

3.18e-064222C0265205
DiseaseRobinow Syndrome, Autosomal Dominant

DVL3 DVL1

3.18e-064222C4551476
DiseaseDiGeorge syndrome (is_implicated_in)

DVL1P1 DVL1

5.30e-065222DOID:11198 (is_implicated_in)
Diseaseneurodegenerative disease (implicated_via_orthology)

DVL3 DVL1P1 DVL1

1.67e-04145223DOID:1289 (implicated_via_orthology)
Diseaselung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma

DVL1P1 DVL1

6.88e-0452222EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Diseaseneutrophil percentage of leukocytes

C11orf98 ZNF800 RERE SNAPC4

9.84e-04610224EFO_0007990
Diseasenicotine dependence

DVL1P1 DVL1

1.54e-0378222EFO_0003768
Diseasehandedness

VANGL2 RSF1

2.82e-03106222EFO_0009902
Diseasecataract

BMP4 ZNF800

4.92e-03141222MONDO_0005129
Diseasemyocardial infarction (biomarker_via_orthology)

DVL1P1 DVL1

6.29e-03160222DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
RKHRDRRDRHRSKSR

VANGL2

21

Q9ULK5
LRKRHKRRSRQHQRF

AEN

26

Q8WTP8
SRLMRRHKRRRRKQK

DVL3

211

Q92997
RHKRRRRKQKVSRIE

DVL3

216

Q92997
RRRRAKRSPKHHSQR

BMP4

286

P12644
RDKSHRHKRARRSRE

RBMX2

296

Q9Y388
RKKAFLRHVRRRHRD

FAM156A

86

Q8NDB6
RKLTHLRKRIHRPRR

KIAA0895

6

Q8NCT3
NRDRKHRRSVDRKRR

PNN

641

Q9H307
RKQHLIRAREQRKRR

PDZD4

681

Q76G19
FLHRRRRVRKRKHHN

KAT6A

1016

Q92794
RTRKRSREHKRRRDR

DRAXIN

131

Q8NBI3
RKHLRRLYRRQERHR

C7orf61

166

Q8IZ16
IRKHKRRRRKQRLRQ

DVL1

216

O14640
IRKHKRRRRKQRLRQ

DVL1P1

216

P54792
RAVKRHRERRERQKR

GPR22

296

Q99680
RRGKEIRRVHKRRLS

RSF1

1231

Q96T23
KHRKRSRSRSRERKR

SCAF8

426

Q9UPN6
KNPKRSRSREHRRHR

LUC7L2

266

Q9Y383
RERRHRSRSRERKKS

RSRC2

131

Q7L4I2
LEHERSRRRKHKRRP

NKTR

216

P30414
RRVKKRHRRQRRSHV

ST6GAL2

171

Q96JF0
RRHRRQAVFRRIKTR

RERE

451

Q9P2R6
KSRSRSRRRHQRKYR

RSRP1

61

Q9BUV0
KRRRVLNRERRLRHR

C11orf98

21

E9PRG8
IHRRQHRSCRRRKRR

PRM2

66

P04554
SRRGVRRHIRKVHKK

ZNF800

241

Q2TB10
KKQGLRRRRRRARHS

SNAPC4

501

Q5SXM2
HTHRRRRLVRKRKKD

MYOF

1016

Q9NZM1