Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	1.04e-05	2	65	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	1.04e-05	2	65	2	GO:0047783
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY5 ADCY6	1.04e-04	5	65	2	GO:0008294
GeneOntologyMolecularFunction	deubiquitinase activator activity	WDR20 DMWD	2.17e-04	7	65	2	GO:0035800
GeneOntologyMolecularFunction	UDP-glucosyltransferase activity	GYS2 UGCG	7.95e-04	13	65	2	GO:0035251
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP11B1 CYP11B2	7.95e-04	13	65	2	GO:0016713
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	1.11e-05	2	47	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	1.11e-05	2	47	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	1.11e-05	2	47	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	1.11e-05	2	47	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	1.11e-05	2	47	2	MP:0011546
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	6.61e-05	4	47	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	6.61e-05	4	47	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	6.61e-05	4	47	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	6.61e-05	4	47	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	6.61e-05	4	47	2	MP:0014459
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	1.10e-04	5	47	2	MP:0014286
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	1.65e-04	6	47	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	1.65e-04	6	47	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	1.65e-04	6	47	2	MP:0009078
MousePheno	disorganized extraembryonic tissue	CUL4B ADAMTS9 UGCG	2.16e-04	35	47	3	MP:0002582
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	2.30e-04	7	47	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	2.30e-04	7	47	2	MP:0000635
MousePheno	abnormal chloride level	CYP11B1 CYP11B2 GYS2 ENTPD1 ADCY6	2.83e-04	174	47	5	MP:0012007
MousePheno	increased circulating angiotensin II level	CYP11B1 CYP11B2	3.06e-04	8	47	2	MP:0031232
MousePheno	increased angiotensin II level	CYP11B1 CYP11B2	3.06e-04	8	47	2	MP:0031229
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2	4.89e-04	10	47	2	MP:0003353
MousePheno	abnormal adrenocortical cell morphology	CYP11B1 CYP11B2	4.89e-04	10	47	2	MP:0008291
MousePheno	abnormal adrenal gland zona fasciculata size	CYP11B1 CYP11B2	5.97e-04	11	47	2	MP:0014284
MousePheno	uterus cyst	CYP11B1 CYP11B2	5.97e-04	11	47	2	MP:0009082
MousePheno	abnormal circulating angiotensin II level	CYP11B1 CYP11B2	7.15e-04	12	47	2	MP:0031230
MousePheno	abnormal angiotensin II level	CYP11B1 CYP11B2	7.15e-04	12	47	2	MP:0031227
MousePheno	hypokalemia	CYP11B1 CYP11B2	7.15e-04	12	47	2	MP:0004119
MousePheno	enlarged pituitary gland	CYP11B1 CYP11B2	7.15e-04	12	47	2	MP:0000636
MousePheno	decreased urine osmolality	CYP11B1 CYP11B2 ADCY6	7.83e-04	54	47	3	MP:0002988
MousePheno	abnormal progesterone level	CYP11B1 CYP11B2 PAPPA	7.83e-04	54	47	3	MP:0011384
MousePheno	increased renin activity	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0005582
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0003374
MousePheno	increased urine osmolality	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0008055
MousePheno	increased circulating adrenocorticotropin level	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0001748
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0002667
MousePheno	endometrium hyperplasia	CYP11B1 CYP11B2	9.81e-04	14	47	2	MP:0009092
MousePheno	absent incisors	TNFRSF11A ACVR2A	1.13e-03	15	47	2	MP:0000125
MousePheno	pale placenta	CUL4B FZR1	1.29e-03	16	47	2	MP:0004266
MousePheno	abnormal urine osmolality	CYP11B1 CYP11B2 ADCY6	1.34e-03	65	47	3	MP:0002987
MousePheno	absent corpus luteum	CYP11B1 CYP11B2 ACVR2A	1.41e-03	66	47	3	MP:0001134
MousePheno	shortened RR interval	WDR6 UBR7	1.46e-03	17	47	2	MP:0010507
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	1.27e-05	2	67	2	IPR002399
Domain	-	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	2.72e-05	679	67	11	3.30.160.60
Domain	zf-C2H2	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	3.28e-05	693	67	11	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	3.32e-05	694	67	11	IPR013087
Domain	KRAB	ZNF677 ZNF182 ZNF337 ZNF205 ZNF766 ZNF227 ZNF446 ZNF284	4.10e-05	358	67	8	PS50805
Domain	KRAB	ZNF677 ZNF182 ZNF337 ZNF205 ZNF766 ZNF227 ZNF446 ZNF284	4.10e-05	358	67	8	PF01352
Domain	KRAB	ZNF677 ZNF182 ZNF337 ZNF205 ZNF766 ZNF227 ZNF446 ZNF284	5.08e-05	369	67	8	SM00349
Domain	KRAB	ZNF677 ZNF182 ZNF337 ZNF205 ZNF766 ZNF227 ZNF446 ZNF284	5.18e-05	370	67	8	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	8.99e-05	775	67	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	9.20e-05	777	67	11	PS00028
Domain	Znf_C2H2-like	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	1.14e-04	796	67	11	IPR015880
Domain	Znf_C2H2	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	1.26e-04	805	67	11	IPR007087
Domain	ZnF_C2H2	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	1.30e-04	808	67	11	SM00355
Domain	Adcy_conserved_dom	ADCY5 ADCY6	1.88e-04	6	67	2	IPR009398
Domain	DUF1053	ADCY5 ADCY6	1.88e-04	6	67	2	PF06327
Domain	WD40	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	3.30e-04	259	67	6	PF00400
Domain	AC_N	ADCY5 ADCY6	3.50e-04	8	67	2	IPR032628
Domain	Adcy	ADCY5 ADCY6	3.50e-04	8	67	2	IPR030672
Domain	AC_N	ADCY5 ADCY6	3.50e-04	8	67	2	PF16214
Domain	WD40	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	3.96e-04	268	67	6	SM00320
Domain	WD40_repeat	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	4.28e-04	272	67	6	IPR001680
Domain	WD_REPEATS_1	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	4.81e-04	278	67	6	PS00678
Domain	WD_REPEATS_2	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	4.90e-04	279	67	6	PS50082
Domain	WD_REPEATS_REGION	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	4.90e-04	279	67	6	PS50294
Domain	WD40_repeat_dom	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	6.80e-04	297	67	6	IPR017986
Domain	-	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	1.23e-03	333	67	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	1.27e-03	335	67	6	IPR015943
Domain	A/G_cyclase_CS	ADCY5 ADCY6	1.67e-03	17	67	2	IPR018297
Domain	Nucleotide_cyclase	ADCY5 ADCY6	1.87e-03	18	67	2	IPR029787
Domain	-	ADCY5 ADCY6	1.87e-03	18	67	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY5 ADCY6	2.08e-03	19	67	2	PS00452
Domain	Guanylate_cyc	ADCY5 ADCY6	2.08e-03	19	67	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY5 ADCY6	2.08e-03	19	67	2	PS50125
Domain	A/G_cyclase	ADCY5 ADCY6	2.08e-03	19	67	2	IPR001054
Domain	CYCc	ADCY5 ADCY6	2.08e-03	19	67	2	SM00044
Domain	HECT	AREL1 HERC6	4.20e-03	27	67	2	PF00632
Domain	HECTc	AREL1 HERC6	4.20e-03	27	67	2	SM00119
Domain	HECT_dom	AREL1 HERC6	4.20e-03	27	67	2	IPR000569
Domain	HECT	AREL1 HERC6	4.20e-03	27	67	2	PS50237
Domain	-	EYS LAMA3 PAPPA	4.83e-03	95	67	3	2.60.120.200
Domain	zf-C2H2_6	ZNF677 ZNF182 ZNF766 ZNF227 ZNF284	5.37e-03	314	67	5	PF13912
Domain	LAM_G_DOMAIN	EYS LAMA3	8.20e-03	38	67	2	PS50025
Domain	Laminin_G_2	EYS LAMA3	9.06e-03	40	67	2	PF02210
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2	1.43e-04	5	54	2	M47522
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	CYP11B1 ADCY5 ADCY6	1.81e-04	29	54	3	M47515
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	CYP11B2 ADCY5 ADCY6	2.21e-04	31	54	3	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	CYP11B1 ADCY5 ADCY6	2.44e-04	32	54	3	M47506
Pathway	REACTOME_CA_DEPENDENT_EVENTS	CAMK2B ADCY5 ADCY6	3.76e-04	37	54	3	M749
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	CAMK2B ADCY5 ADCY6	5.11e-04	41	54	3	M512
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY5 ADCY6	6.35e-04	10	54	2	M19522
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	6.35e-04	10	54	2	M27076
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY5 ADCY6	6.35e-04	10	54	2	MM14668
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	7.75e-04	11	54	2	MM14750
Pathway	REACTOME_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	9.27e-04	12	54	2	MM14749
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	CAMK2B ADCY5 ADCY6	1.15e-03	54	54	3	M26911
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	USP13 FLT3 CAMK2B ADCY5 ADCY6 PREX2	1.20e-03	313	54	6	M27867
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.27e-03	14	54	2	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2	1.27e-03	14	54	2	M46453
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY5 ADCY6	1.27e-03	14	54	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY5 ADCY6	1.27e-03	14	54	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY5 ADCY6	1.46e-03	15	54	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY5 ADCY6	1.46e-03	15	54	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY5 ADCY6	1.46e-03	15	54	2	M47504
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY5 ADCY6	1.67e-03	16	54	2	M39849
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2	1.67e-03	16	54	2	M39815
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY5 ADCY6	1.67e-03	16	54	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY5 ADCY6	1.67e-03	16	54	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY5 ADCY6	1.67e-03	16	54	2	MM14492
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY5 ADCY6	1.89e-03	17	54	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY5 ADCY6	1.89e-03	17	54	2	M47544
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	CAMK2B GRIK3 ADCY5 ADCY6	2.22e-03	144	54	4	MM14501
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	3.77e-06	2	68	2	17651452
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	3.77e-06	2	68	2	23150505
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	34743356
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	3.77e-06	2	68	2	21164264
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	20808686
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	3.77e-06	2	68	2	8645611
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	3.77e-06	2	68	2	12231255
Pubmed	Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.	ADCY5 ADCY6	3.77e-06	2	68	2	23609114
Pubmed	Adenylyl cyclase type 5 protein expression during cardiac development and stress.	ADCY5 ADCY6	3.77e-06	2	68	2	19734365
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	3.77e-06	2	68	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	3.77e-06	2	68	2	1303253
Pubmed	Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.	ADCY5 ADCY6	3.77e-06	2	68	2	31009605
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	3.77e-06	2	68	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	3.77e-06	2	68	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	3.77e-06	2	68	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	3.77e-06	2	68	2	26066897
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	3.77e-06	2	68	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	3.77e-06	2	68	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	3.77e-06	2	68	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	3.77e-06	2	68	2	26324851
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	3.77e-06	2	68	2	18651133
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	3.77e-06	2	68	2	7669222
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	3.77e-06	2	68	2	22083159
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	3.77e-06	2	68	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	3.77e-06	2	68	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	2256920
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	3.77e-06	2	68	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	3.77e-06	2	68	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	3.77e-06	2	68	2	38341019
Pubmed	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	ADCY5 ADCY6	3.77e-06	2	68	2	17068292
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	3.77e-06	2	68	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	3.77e-06	2	68	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	3.77e-06	2	68	2	16396990
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	3.77e-06	2	68	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	3.77e-06	2	68	2	30046010
Pubmed	Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.	ADCY5 ADCY6	3.77e-06	2	68	2	31162142
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	3.77e-06	2	68	2	19820005
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	3.77e-06	2	68	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	3.77e-06	2	68	2	1518866
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	3.77e-06	2	68	2	22622494
Pubmed	Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.	ADCY5 ADCY6	3.77e-06	2	68	2	20431059
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	3.77e-06	2	68	2	15062555
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	3.77e-06	2	68	2	23761669
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	3.77e-06	2	68	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	3.77e-06	2	68	2	17075029
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	3.77e-06	2	68	2	2592361
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	3.77e-06	2	68	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	3.77e-06	2	68	2	17296872
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	3.77e-06	2	68	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	3.77e-06	2	68	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	3.77e-06	2	68	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	3.77e-06	2	68	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	3.77e-06	2	68	2	15731365
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	3.77e-06	2	68	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	3.77e-06	2	68	2	19029289
Pubmed	Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.	ADCY5 ADCY6	3.77e-06	2	68	2	21282557
Pubmed	USP13 modulates the stability of the APC/C adaptor CDH1.	USP13 FZR1	3.77e-06	2	68	2	35397714
Pubmed	Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.	ADCY5 ADCY6	3.77e-06	2	68	2	10481931
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	3.77e-06	2	68	2	15522937
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	EYS WDR6 NSD2 WDR20 LRRTM2 UGCG PLD4	3.99e-06	332	68	7	37433992
Pubmed	Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.	CYP11B1 CYP11B2 SDS	6.77e-06	19	68	3	7628695
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	1.13e-05	3	68	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	1.13e-05	3	68	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	1.13e-05	3	68	2	8111631
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	1.13e-05	3	68	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	1.13e-05	3	68	2	16118390
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	1.13e-05	3	68	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	1.13e-05	3	68	2	18974272
Pubmed	Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.	ADCY5 ADCY6	1.13e-05	3	68	2	31173603
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	1.13e-05	3	68	2	17984374
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	1.13e-05	3	68	2	1686470
Pubmed	Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.	ADCY5 ADCY6	1.13e-05	3	68	2	16973443
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.13e-05	3	68	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	1.13e-05	3	68	2	33271253
Pubmed	Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.	ADCY5 ADCY6	1.13e-05	3	68	2	27826057
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	1.13e-05	3	68	2	35830806
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	1.13e-05	3	68	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	1.13e-05	3	68	2	11932209
Pubmed	Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.	ADCY5 ADCY6	1.13e-05	3	68	2	8034296
Pubmed	Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis.	CHFR PAPPA	1.13e-05	3	68	2	34842180
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	1.13e-05	3	68	2	21467193
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	1.13e-05	3	68	2	24285498
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	1.13e-05	3	68	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	1.13e-05	3	68	2	26471128
Pubmed	Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.	ADCY5 ADCY6	1.13e-05	3	68	2	19889965
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	1.13e-05	3	68	2	28355486
Pubmed	Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.	ADCY5 ADCY6	1.13e-05	3	68	2	17593019
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	1.13e-05	3	68	2	32245948
Pubmed	Zona Glomerulosa-Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice.	CYP11B1 CYP11B2	2.25e-05	4	68	2	38573585
Pubmed	Adrenal Abcg1 Controls Cholesterol Flux and Steroidogenesis.	CYP11B1 CYP11B2	2.25e-05	4	68	2	38301271
Pubmed	Crosstalk between androgen receptor and WNT/β-catenin signaling causes sex-specific adrenocortical hyperplasia in mice.	CYP11B1 CYP11B2	2.25e-05	4	68	2	37102205
Pubmed	Familial varieties of primary aldosteronism.	CYP11B1 CYP11B2	2.25e-05	4	68	2	11903322
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	CYP11B1 CYP11B2	2.25e-05	4	68	2	19342457
Pubmed	Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.	CYP11B1 CYP11B2	2.25e-05	4	68	2	29440508
Pubmed	The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.	CYP11B1 CYP11B2	2.25e-05	4	68	2	23303406
Pubmed	Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.	CYP11B1 CYP11B2	2.25e-05	4	68	2	30917317
Pubmed	The dystrophia myotonica WD repeat-containing protein DMWD and WDR20 differentially regulate USP12 deubiquitinase.	WDR20 DMWD	2.25e-05	4	68	2	33844468
Pubmed	Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminus.	CAMK2B ITPKA	2.25e-05	4	68	2	11468283
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	CYP11B1 CYP11B2 GLI4 BOP1 FAM83A	1.88e-04	355	68	5	chr8q24
Cytoband	9q31	TMEM245 UGCG	2.90e-04	17	68	2	9q31
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF677 CTCFL ZNF182 ZNF337 GLI4 ZNF205 ZNF766 ZNF227 ZNF232 ZNF446 ZNF284	4.00e-06	718	51	11	28
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	2.34e-05	3	51	2	1007
GeneFamily	WD repeat domain containing	FZR1 DCAF13 WDR6 WDR20 BOP1 DMWD	9.12e-05	262	51	6	362
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY5 ADCY6	3.46e-04	10	51	2	53
ToppCell	Control-Myeloid-Migratory_DC\|Myeloid / Condition, Lineage and Cell class	FLT3 ENTPD1 UGCG P2RY8 TNFRSF11A SDS	5.37e-07	195	68	6	9f1ad04abc6a6c5e093ea24b60732871b1fad5a4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 SLC9A2 ADAMTS9 PAPPA GRIK3	9.91e-06	187	68	5	85f1678338a47d91e296f0620d4887f057eb7e70
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL8A1 CAMK2B UGCG LAMA3 ADCY5	1.02e-05	188	68	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL8A1 CAMK2B UGCG LAMA3 ADCY5	1.02e-05	188	68	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS9 ENTPD1 UGCG PREX2 LIMS2	1.07e-05	190	68	5	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COL8A1 SLC9A2 CAMK2B ADCY5 LIMS2	1.10e-05	191	68	5	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS SLC9A2 PAPPA GRIK3	1.15e-05	193	68	5	4979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS SLC9A2 PAPPA GRIK3	1.15e-05	193	68	5	e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS SLC9A2 PAPPA GRIK3	1.15e-05	193	68	5	658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCell	10x5'-Lung-Myeloid_Dendritic-DC2\|Lung / Manually curated celltypes from each tissue	FLT3 ENTPD1 UGCG SDS PLD4	1.15e-05	193	68	5	c97f9b13057f803df63c696c6175ef8e0aba6fa7
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS SLC9A2 PAPPA GRIK3	1.18e-05	194	68	5	e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCell	Control-Myeloid-Migratory_DC\|Control / Condition, Lineage and Cell class	FLT3 ENTPD1 UGCG TNFRSF11A SDS	1.18e-05	194	68	5	374076e60dcee83eb1814aa6b55b77668909f40b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS SLC9A2 PAPPA GRIK3	1.18e-05	194	68	5	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FLT3 ENTPD1 CTRC TNFRSF11A PLD4	1.27e-05	197	68	5	e2c53742c7d8d1b63d93843f82330b9e20f1faa6
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	DNAH10 UGCG ZNF227 UBR7 PLD4	1.34e-05	199	68	5	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_activated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3 ENTPD1 P2RY8 TNFRSF11A PLD4	1.34e-05	199	68	5	82759af613ebfffe037afda55159bf6af812c3ac
ToppCell	Tracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FLT3 CAMK2B GRIK3 ZNF232 ZNF446	1.34e-05	199	68	5	4e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FLT3 EYS ADAMTS9 PAPPA GRIK3	1.37e-05	200	68	5	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	LPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLT3 EYS UGCG ANKRD30A PLD4	1.37e-05	200	68	5	6a34e07e6d77fe3fdd9ff44c4b1e46a023f6d6a2
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL8A1 ADAMTS9 ENTPD1 PREX2 LIMS2	1.37e-05	200	68	5	5ec31c1be6bcc4124e1489d136570f3de33cc2e9
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FLT3 EYS ADAMTS9 PAPPA GRIK3	1.37e-05	200	68	5	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FLT3 EYS ADAMTS9 PAPPA GRIK3	1.37e-05	200	68	5	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4-Inhibitory_Neuron.Gad1Gad2_Sst.Atp2b4_(Interneuron,_Olm)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP2C1 ACR PAPPA	4.78e-05	46	68	3	1259dca3ada3ba697ce50268163bd3b63e3c77bc
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP2C1 ACR PAPPA	4.78e-05	46	68	3	457e258b9b38e581b69ff92fc02d552c24d841cf
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Atp2b4-Inhibitory_Neuron.Gad1Gad2_Sst.Atp2b4_(Interneuron,_Olm)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP2C1 ACR PAPPA	4.78e-05	46	68	3	5c1cd6647dd412162273fa01a73f65d62d422038
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF677 EYS CHFR ANKRD30A	6.09e-05	139	68	4	d96e5c17582f1576fa09d6bad35c418b6248448c
ToppCell	AT1-AT2_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	USP13 COL8A1 ADAMTS9 LAMA3	6.27e-05	140	68	4	45d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCell	tumor_Lung-Myeloid_cells-Pleural_Mac\|Myeloid_cells / Location, Cell class and cell subclass	FLT3 SLC9A2 DMWD CRAMP1	7.37e-05	146	68	4	8b2d104fdb0fdb09410450c6c651e1edb00cae44
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT3 ENTPD1 CTRC ZNF284	8.62e-05	152	68	4	0769857f25da2e6169420818e61d65e33b7277b1
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 DNAH10 SDS PLD4	8.84e-05	153	68	4	91e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 DNAH10 SDS PLD4	8.84e-05	153	68	4	f17f62646633cf95c810dcd5328978058741b276
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9A2 CAMK2B UGCG CHORDC1	9.07e-05	154	68	4	75eac6970259a6916fcfa6d3400509cfa2d98d9d
ToppCell	COVID-19-APC-like-Alveolar_macrophages\|COVID-19 / group, cell type (main and fine annotations)	ZNF182 FLT3 EYS FAM200B	9.53e-05	156	68	4	735ade77cfa16b9386a0c7ec2bd14bd2e78a51ad
ToppCell	10x5'v1-week_12-13-Myeloid_DC-DC-DC2\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FLT3 SLC9A2 DNAH10 PLD4	9.53e-05	156	68	4	03f3c5ffb27758fe63797143fcc938f9e8a4e10d
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 TNFRSF11A SDS PLD4	9.77e-05	157	68	4	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WDR6 CYP11B1 PLPP4 GRIK3	9.77e-05	157	68	4	741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 TNFRSF11A SDS PLD4	1.00e-04	158	68	4	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	21-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	COL8A1 ADAMTS9 CAMK2B ADCY5	1.03e-04	159	68	4	4f670b57b8d3b090ea2f1aafe15baf93cb7ef146
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ENTPD1 P2RY8 PREX2 LIMS2	1.13e-04	163	68	4	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	Adult-Immune-dendritic_cell\|Adult / Lineage, Cell type, age group and donor	FLT3 ENTPD1 UGCG P2RY8	1.18e-04	165	68	4	073f52698dac1fe4edd7410865f81b30e1c7196a
ToppCell	Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, Lineage and Cell Type	DNAH10 UGCG UBR7 PLD4	1.18e-04	165	68	4	8728f927502e56f2768b4224e9111939d3d7815a
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 ENTPD1 PREX2 PLD4	1.21e-04	166	68	4	d373f1092e85eeb317a7406032b259f11e6adbe0
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 ENTPD1 PREX2 PLD4	1.21e-04	166	68	4	f453a1d545d59003d98485ac31e85e6cf451817c
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	FLT3 CHFR ZNF227 SDS	1.27e-04	168	68	4	8459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCell	PCW_05-06-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ENTPD1 P2RY8 TNFRSF11A HERC6	1.30e-04	169	68	4	45ac692a0c9064ce6b6a31c2cd21c85ccf594670
ToppCell	PCW_05-06-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_natural_killer_[NK]_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ENTPD1 P2RY8 TNFRSF11A HERC6	1.30e-04	169	68	4	3514a74980c7bd4bb76dbd06693f492e8dce21e0
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS9 ENTPD1 PREX2 LIMS2	1.33e-04	170	68	4	1a568efcff9c39b3f709b55a05d24710450a2657
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS9 ENTPD1 PREX2 LIMS2	1.33e-04	170	68	4	66d41d794790e621d72ac37af995510537103c9c
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	FLT3 ENTPD1 UGCG PLD4	1.36e-04	171	68	4	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENGASE CAMK2B TNFRSF11A PLD4	1.36e-04	171	68	4	d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCell	facs-Marrow-KLS-18m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 TNFRSF11A SOWAHC PLD4	1.39e-04	172	68	4	979fd7b435f59b8a4d290a809cf76147d4c63d48
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A2 LAMA3 PLPP4 SOWAHC	1.39e-04	172	68	4	8b396d1e9173da104d467e42286379fe07cee257
ToppCell	facs-Marrow-KLS-18m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 TNFRSF11A SOWAHC PLD4	1.39e-04	172	68	4	f4d7f416802218ce56408fa4cb8a555d846bc85b
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLT3 NSD2 TNFRSF11A PLD4	1.42e-04	173	68	4	a55f310c533432e9e26e400026a5b47245152976
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLT3 NSD2 TNFRSF11A PLD4	1.42e-04	173	68	4	9c7386bf0a899882c733f0b4921a96afde032a7d
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS9 UGCG PAPPA ADCY6	1.45e-04	174	68	4	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PLPP4 GRIK3	1.52e-04	176	68	4	322259a35f5c97d73ce7f75835dcdb5c954c91f8
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT3 CTRC TNFRSF11A PLD4	1.52e-04	176	68	4	7b5e50eb144bf43ca0cf354a466eb58b976a79f1
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	FLT3 UGCG P2RY8 TNFRSF11A	1.52e-04	176	68	4	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PLPP4 GRIK3	1.52e-04	176	68	4	014aa4a9aeae37309d7e05b20a06893a50f10bfe
ToppCell	Dendritic_Cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	FLT3 ENTPD1 TNFRSF11A PLD4	1.55e-04	177	68	4	d2cd081bdda0eba9f6f6473c4d3939e4bee3440e
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP13 FLT3 NSD2 PLD4	1.55e-04	177	68	4	cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCell	ILEUM-inflamed-(9)_Enteric_neurons\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL8A1 ANKRD30A PAPPA GRIK3	1.58e-04	178	68	4	d9142151819afb0dc22bfb32a9c9dba5f553067d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PAPPA GRIK3	1.58e-04	178	68	4	6ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-2_PVALB_TAC1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PREX2 OTOG	1.58e-04	178	68	4	1985271984e6747941c8d2097d9c58f0260f021a
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	USP13 FLT3 NSD2 PLD4	1.58e-04	178	68	4	04bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCell	Dendritic_Cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	FLT3 ENTPD1 SDS PLD4	1.58e-04	178	68	4	3a28103cf282cc3637d1875a3b4cd7ddf3207687
ToppCell	ILEUM-inflamed-(9)_Neuro_cell\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL8A1 ANKRD30A PAPPA GRIK3	1.58e-04	178	68	4	611504b0a9e6318b18fba83787b03f9245c82252
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	UXS1 SLC9A2 ENTPD1 UGCG	1.62e-04	179	68	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS9 ENTPD1 PREX2 LIMS2	1.62e-04	179	68	4	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.69e-04	181	68	4	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	Severe-Myeloid-mDC\|Severe / Condition, Lineage, Cell class and cell subclass	FLT3 ENTPD1 PREX2 PLD4	1.69e-04	181	68	4	00f2949b609ac21bd2da6fd8f685739eeb2f48ad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-2_VIP_PPAPDC1A\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC9A2 LAMA3 PLPP4 PREX2	1.69e-04	181	68	4	42f5a645beeb5a1a746d79ea7fe7fd3786fd35ad
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.69e-04	181	68	4	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.69e-04	181	68	4	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	Severe-Myeloid-mDC-\|Severe / Condition, Lineage, Cell class and cell subclass	FLT3 ENTPD1 PREX2 PLD4	1.69e-04	181	68	4	51ded98c76ec35ab1d24ac3ab98280381daa9831
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.69e-04	181	68	4	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	CTRL-Myeloid-cDC\|Myeloid / Disease state, Lineage and Cell class	FLT3 TNFRSF11A SDS PLD4	1.72e-04	182	68	4	ee137574b8f0e684a4a7cb26226877c471cae433
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ENGASE FLT3 EYS GRIK3	1.72e-04	182	68	4	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3 SLC9A2 LAMA3 PLD4	1.72e-04	182	68	4	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	ADAMTS9 ENTPD1 LAMA3 ADCY5	1.76e-04	183	68	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	FLT3 ENTPD1 TNFRSF11A PLD4	1.76e-04	183	68	4	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLT3 P2RY8 TNFRSF11A PLD4	1.76e-04	183	68	4	24679153b654c148dbd572e9013c0a6e58718ada
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PAPPA GRIK3	1.76e-04	183	68	4	04d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell	CTRL-Myeloid-cDC\|CTRL / Disease state, Lineage and Cell class	FLT3 ENTPD1 SDS PLD4	1.76e-04	183	68	4	20c4d16de7e090df3556a4458f783383a26871b6
ToppCell	COVID-19-Heart-EC_3\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS9 ENTPD1 PREX2 LIMS2	1.76e-04	183	68	4	ff95382cfed592190d0636d2b750328471f82e0d
ToppCell	Control-Endothelial_cells-Pulmonary_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	ADAMTS9 ENTPD1 PREX2 LIMS2	1.76e-04	183	68	4	46be9f96755c7b65aeac061d95d15abeb6466034
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.80e-04	184	68	4	a60802e11dcc5f932811260b08a95a32f60f6b19
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.80e-04	184	68	4	39c230d32e4259bc784e0edfd9e2884c96898564
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC9A2 CAMK2B ANKRD30A ADCY5	1.80e-04	184	68	4	2a2fb691cc9414ef5b06c26239d2da03d6d7e5c2
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 SLC9A2 ADAMTS9 GRIK3	1.80e-04	184	68	4	7f6c8912677764d438ab0555faca344d74c2f483
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 SLC9A2 PAPPA GRIK3	1.80e-04	184	68	4	23515c28e1f42aab29cef9e5b4a7f45bda7f5520
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	USP13 ADAMTS9 UGCG P2RY8	1.83e-04	185	68	4	673308ca0514a4d3629d61fe91e9d8fb31b72166
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS9 ADCY5 ADCY6 PREX2	1.83e-04	185	68	4	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	Mild_COVID-19-Epithelial-AT1/AT2\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	COL8A1 SLC9A2 ADAMTS9 CAMK2B	1.83e-04	185	68	4	c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Mega-Mast\|bone_marrow / Manually curated celltypes from each tissue	USP13 LINC02910 ADCY6 ITPKA	1.83e-04	185	68	4	a62ebaff92f2ed27b27b32c27c89cfbe2cb35116
ToppCell	10x5'-Liver-Myeloid_Dendritic-DC2\|Liver / Manually curated celltypes from each tissue	FLT3 ENTPD1 SDS PLD4	1.87e-04	186	68	4	92ef569c8f864d3abaa087cd3ce0366e8f9f50c2
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 SLC9A2 ADAMTS9 GRIK3	1.87e-04	186	68	4	96f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FLT3 EYS PAPPA GRIK3	1.91e-04	187	68	4	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS9 ENTPD1 PREX2 LIMS2	1.91e-04	187	68	4	e35716f8b482be3bf5ab79f087a9caf67a9d197a
Computational	Neighborhood of PDPK1	FZR1 ZNF337 CAMK2B ACR	1.57e-04	74	40	4	MORF_PDPK1
Drug	cyadox	CYP11B1 CYP11B2	8.79e-06	2	68	2	ctd:C020728
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	8.79e-06	2	68	2	ctd:C042509
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	4.93e-06	2	66	2	DOID:0050891 (is_marker_for)
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	4.93e-06	2	66	2	C1260386
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	1.48e-05	3	66	2	DOID:0050811 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	4.91e-05	5	66	2	DOID:446 (is_implicated_in)
Disease	interleukin-27 measurement	CYP11B1 MYDGF	7.35e-05	6	66	2	EFO_0010916
Disease	Conn Syndrome	CYP11B1 CYP11B2	7.35e-05	6	66	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	7.35e-05	6	66	2	C0020428
Disease	myocarditis (biomarker_via_orthology)	CYP11B1 TNFRSF11A	1.03e-04	7	66	2	DOID:820 (biomarker_via_orthology)
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	1.03e-04	7	66	2	EFO_0801973
Disease	skeletal age	CYP11B1 FANCA	1.03e-04	7	66	2	EFO_0020898
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	1.76e-04	9	66	2	EFO_0802936
Disease	L2 Acute Lymphoblastic Leukemia	FLT3 NSD2 P2RY8	1.94e-04	50	66	3	C0023453
Disease	Childhood Acute Lymphoblastic Leukemia	FLT3 NSD2 P2RY8	2.18e-04	52	66	3	C0023452
Disease	androstenedione measurement	CYP11B1 CYP11B2	2.19e-04	10	66	2	EFO_0007972
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	2.68e-04	11	66	2	EFO_0021862
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	2.68e-04	11	66	2	EFO_0801461
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	FLT3 NSD2 P2RY8	3.51e-04	61	66	3	C1961102
Disease	leprosy, Crohn's disease	SLC9A2 MYDGF	9.12e-04	20	66	2	EFO_0000384, EFO_0001054
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	1.43e-03	25	66	2	EFO_0021854
Disease	glucose tolerance test	CAMK2B ADCY5	1.67e-03	27	66	2	EFO_0004307

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFTGRKRNVEHWIGH	UXS1	121	Q8NBZ7
ICHGKPVTQVTWHGR	BOP1	531	Q14137
AVWNHCFIHREGLAS	FAM200B	321	P0CF97
CGKGFSRWINLHRHS	CTCFL	551	Q8NI51
AAHCFVGKNNVHDWR	ACR	86	P10323
HSGRVHCGVLGLRKW	ADCY6	476	O43306
AGIVICAFWVYRHHK	ACVR2A	151	P27037
NKHGCQVHFGRWLIE	GYS2	96	P54840
AQKRTALHWACVNGH	ANKRD30A	71	Q9BXX3
WQADGYGHSHRLKCQ	LINC02910	11	Q8N268
HSGRVHCGVLGLRKW	ADCY5	566	O95622
VARGHGHKSWVNAVA	DMWD	361	Q09019
GIDHHWKEAVFATCG	DCAF13	161	Q9NV06
LNKCEVSHRRAFHGW	ATP2C1	46	P98194
RHHWVFGVLLCNVVT	P2RY8	86	Q86VZ1
LGSFQGRWEHSILCH	LRRTM2	326	O43300
NALGKQWHVEHFVCA	LIMS2	211	Q7Z4I7
VHTVHLGKFFQEGWL	EYS	2511	Q5T1H1
EKCNDGKWHTVVFGH	LAMA3	3061	Q16787
WKSFFGCLRNIHVNH	LAMA3	3296	Q16787
KGKRHHAHVNVSWCF	NSD2	821	O96028
HSLAVCHKGRVFAWG	HERC6	86	Q8IVU3
WLCGHVHRNILSKFT	FAM83A	261	Q86UY5
IHCRKDGTWNGSFHV	PAPPA	1456	Q13219
HIHFIGKIQGSDAGW	ENTPD1	436	P49961
KHHWQDSFVGGVIGL	PLPP4	201	Q5VZY2
HCHRAGVWLIDFGKT	ITPKA	406	P23677
FNKHIGTRGWQAAAH	PPP1R37	171	O75864
GVLHSKFWVVDGRHI	PLD4	211	Q96BZ4
RCKAVHVNHGFGLTW	FLT3	271	P36888
GHRQEVCGLKWSTDH	FZR1	311	Q9UM11
GHKHRQVWCQFGEDR	ADAMTS9	1071	Q9P2N4
YWGRNCRTQVKAHHA	CHFR	636	Q96EP1
FVGVDTIHVHKRWNA	CTRC	101	Q99895
THKIVRCWFGVFSGH	FANCA	291	O15360
VHSKAFCTVHWQEGG	CRAMP1	416	Q96RY5
WVAYRQHRGHKCGVF	CYP11B1	116	P15538
CGKRFRGWSGFIQHH	GLI4	216	P10075
KAHAVVVGGSWHFRE	AREL1	716	O15033
CFVASLIIGWAAHHV	UGCG	296	Q16739
HVHCKGGNVWVALFK	COL8A1	666	P27658
CQRKGHKAHWAVSAG	C19orf54	226	Q5BKX5
WVAYRQHRGHKCGVF	CYP11B2	116	P19099
HRHGVCVLGTFITEW	ENGASE	181	Q8NFI3
NSLQCHRHKAWRFGG	GRIK3	346	Q13003
FTTRHISHWVLQGVC	DNAH10	4451	Q8IVF4
GHFCKRWAKQGCAHF	SDS	46	P20132
HSGRKLQWQSTLGHC	CUL4B	716	Q13620
ICRAWGQHHVETFDG	OTOG	151	Q6ZRI0
RDGKWQNVHFHCSGA	CAMK2B	646	Q13554
VIARGHGHKSWVSVV	WDR20	296	Q8TBZ3
TGFTCLHWAAKHGRQ	SOWAHC	301	Q53LP3
KVVPCRHDWHQTGGE	CHORDC1	226	Q9UHD1
VHWRTHTGEKPFGCT	ZNF182	251	P17025
KTGIEDVCGHWGHNF	SLC9A2	511	Q9UBY0
DFHSSGHIVVNGWKI	PREX2	316	Q70Z35
IGHCFGHSARVWQVK	WDR6	251	Q9NNW5
QCGRGFDWKSVFVIH	ZNF446	336	Q9NWS9
ECGKAFIQRSHLWGH	ZNF677	351	Q86XU0
WFVKNVTHSGRHKGQ	TMEM245	571	Q9H330
EQCGKGFSWHSHLVT	ZNF205	311	O95201
VVCEDWFHGRHLGAI	UBR7	156	Q8N806
CGKGFSWRSNLHAHQ	ZNF227	581	Q86WZ6
ECGKAFRWGAHLVQH	ZNF232	336	Q9UNY5
CHVCGKVFRHSSWFV	ZNF766	441	Q5HY98
SGHYICHIKKEGRWV	USP13	821	Q92995
CGKGFRWASTHLTHQ	ZNF284	516	Q2VY69
PWTNCTFLGKRVEHH	TNFRSF11A	171	Q9Y6Q6
CGQGFSWKRSLTRHH	ZNF337	661	Q9Y3M9
DHQHFTCTIWRPQGK	MYDGF	86	Q969H8