Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	2.67e-06	5	130	3	GO:0030156
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK1 ARHGAP42 A2M DENND5B BMP2K BCAS3 SIPA1L3 OBSCN STK4 STK11 ARHGEF40 NF1 PLAA STYX SIPA1L1 FURIN SOCS5 SIPA1L2 DNMBP ACAP2 ALK TNS3 LILRB4	4.10e-05	1418	130	23	GO:0030234
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK1 ARHGAP42 DENND5B SIPA1L3 OBSCN ARHGEF40 NF1 SIPA1L1 SIPA1L2 DNMBP ACAP2 TNS3	1.21e-04	507	130	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK1 ARHGAP42 DENND5B SIPA1L3 OBSCN ARHGEF40 NF1 SIPA1L1 SIPA1L2 DNMBP ACAP2 TNS3	1.21e-04	507	130	12	GO:0030695
GeneOntologyMolecularFunction	structural constituent of nuclear pore	POM121C POM121 NUP155	5.58e-04	25	130	3	GO:0017056
GeneOntologyMolecularFunction	phosphatase activity	ENPP7 RNGTT INPP5D MTMR4 FIG4 PTPRO TNS1 TNS3	5.91e-04	287	130	8	GO:0016791
GeneOntologyMolecularFunction	chitinase activity	CHIT1 OVGP1	6.20e-04	6	130	2	GO:0004568
GeneOntologyMolecularFunction	phosphatidylinositol bisphosphate phosphatase activity	INPP5D MTMR4 FIG4	7.03e-04	27	130	3	GO:0034593
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	INPP5D FIG4	8.65e-04	7	130	2	GO:0034485
GeneOntologyMolecularFunction	phosphatidylinositol phosphate phosphatase activity	INPP5D MTMR4 FIG4	9.63e-04	30	130	3	GO:0052866
GeneOntologyMolecularFunction	integrin binding	MYH9 ISG15 PRKCA TNXB CDH17 LILRB4	1.01e-03	175	130	6	GO:0005178
GeneOntologyMolecularFunction	cobalt ion binding	SLC11A2 RNPEP	1.15e-03	8	130	2	GO:0050897
GeneOntologyMolecularFunction	nerve growth factor binding	A2M FURIN	1.15e-03	8	130	2	GO:0048406
GeneOntologyMolecularFunction	chitin binding	CHIT1 OVGP1	1.15e-03	8	130	2	GO:0008061
GeneOntologyMolecularFunction	enzyme activator activity	DOCK1 ARHGAP42 BCAS3 SIPA1L3 STK4 STK11 NF1 PLAA SIPA1L1 SIPA1L2 ACAP2 ALK	1.21e-03	656	130	12	GO:0008047
GeneOntologyBiologicalProcess	myeloid cell homeostasis	GPI SLC11A2 INPP5D HEPH NF1 ISG15 VPS13A HSPA9 RAC1 LILRB4	3.18e-06	240	131	10	GO:0002262
GeneOntologyBiologicalProcess	erythrocyte homeostasis	GPI SLC11A2 INPP5D HEPH ISG15 VPS13A HSPA9 RAC1	2.95e-05	190	131	8	GO:0034101
GeneOntologyBiologicalProcess	cellular response to phenylpropanoid	UGT3A1 UGT3A2	4.00e-05	2	131	2	GO:1905546
GeneOntologyBiologicalProcess	cellular response to hydroxyisoflavone	UGT3A1 UGT3A2	4.00e-05	2	131	2	GO:0071413
GeneOntologyBiologicalProcess	cellular response to genistein	UGT3A1 UGT3A2	4.00e-05	2	131	2	GO:0071412
GeneOntologyBiologicalProcess	regulation of small GTPase mediated signal transduction	ARHGAP42 SIPA1L3 OBSCN ARHGEF40 NF1 SIPA1L1 SIPA1L2 DNMBP TNS3 RAC1	5.40e-05	333	131	10	GO:0051056
GeneOntologyBiologicalProcess	neuromuscular synaptic transmission	CHRNB1 RIMBP3 RIMBP3C RIMBP3B	7.82e-05	36	131	4	GO:0007274
GeneOntologyBiologicalProcess	hemopoiesis	DOCK1 MYH9 SLC11A2 INPP5D SIPA1L3 AIRE HEPH STK4 STK11 NF1 ISG15 SOCS5 VPS13A FBXO7 PRKCA DHTKD1 HSPA9 CDH17 RAC1 LILRB4	8.97e-05	1223	131	20	GO:0030097
GeneOntologyBiologicalProcess	protein localization to nucleus	POM121C ZIC1 STK4 CDKL5 STK11 POM121 NF1 NUP155 TNPO3 LILRB4	1.08e-04	362	131	10	GO:0034504
GeneOntologyBiologicalProcess	response to environmental enrichment	VPS13A ALK	1.20e-04	3	131	2	GO:0090648
GeneOntologyBiologicalProcess	response to genistein	UGT3A1 UGT3A2	1.20e-04	3	131	2	GO:0033595
GeneOntologyBiologicalProcess	erythrocyte differentiation	SLC11A2 INPP5D HEPH ISG15 VPS13A HSPA9 RAC1	1.34e-04	176	131	7	GO:0030218
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	DOCK1 ARHGAP42 SIPA1L3 DOK3 OBSCN ARHGEF40 NF1 SIPA1L1 SIPA1L2 DNMBP TNS3 RAC1	1.67e-04	538	131	12	GO:0007264
GeneOntologyBiologicalProcess	cell morphogenesis	MYH9 SLC11A2 SIPA1L3 MGLL SYT2 STK4 CDKL5 STK11 ARHGEF40 PLAA PTPRO SIPA1L1 SEC24B VPS13A LRP1 PRKCA DNMBP CDH17 RAC1	1.95e-04	1194	131	19	GO:0000902
Domain	SPAR_C	SIPA1L3 SIPA1L1 SIPA1L2	3.22e-07	3	129	3	PF11881
Domain	SIPA1L_C	SIPA1L3 SIPA1L1 SIPA1L2	3.22e-07	3	129	3	IPR021818
Domain	SH3_9	DOCK1 ARHGAP42 RIMBP3 RIMBP3C RIMBP3B DNMBP	1.65e-05	78	129	6	PF14604
Domain	Rap_GAP	SIPA1L3 SIPA1L1 SIPA1L2	3.73e-05	10	129	3	PF02145
Domain	-	RNGTT MTMR4 STYX PTPRO TNS1 TNS3	4.24e-05	92	129	6	3.90.190.10
Domain	Rap_GAP_dom	SIPA1L3 SIPA1L1 SIPA1L2	5.10e-05	11	129	3	IPR000331
Domain	RAPGAP	SIPA1L3 SIPA1L1 SIPA1L2	5.10e-05	11	129	3	PS50085
Domain	Prot-tyrosine_phosphatase-like	RNGTT MTMR4 STYX PTPRO TNS1 TNS3	6.40e-05	99	129	6	IPR029021
Domain	-	ARHGAP42 DOK3 OBSCN PLEKHA6 ARHGEF40 MTMR4 ELMO3 OSBPL5 ACAP2 TNS1 TNS3	8.60e-05	391	129	11	2.30.29.30
Domain	SH3	DOCK1 ARHGAP42 OBSCN RIMBP3 SHANK2 RIMBP3C RIMBP3B DNMBP	1.29e-04	216	129	8	SM00326
Domain	SH3	DOCK1 ARHGAP42 OBSCN RIMBP3 SHANK2 RIMBP3C RIMBP3B DNMBP	1.29e-04	216	129	8	PS50002
Domain	SH3_domain	DOCK1 ARHGAP42 OBSCN RIMBP3 SHANK2 RIMBP3C RIMBP3B DNMBP	1.47e-04	220	129	8	IPR001452
Domain	PH_dom-like	ARHGAP42 DOK3 OBSCN PLEKHA6 ARHGEF40 MTMR4 ELMO3 OSBPL5 ACAP2 TNS1 TNS3	1.82e-04	426	129	11	IPR011993
Domain	Tensin_PTB	TNS1 TNS3	2.81e-04	4	129	2	IPR033929
Domain	BAR	ARHGAP42 DNMBP ACAP2	2.88e-04	19	129	3	PS51021
Domain	SH3_2	RIMBP3 SHANK2 RIMBP3C RIMBP3B DNMBP	3.24e-04	86	129	5	PF07653
Domain	SH3_2	RIMBP3 SHANK2 RIMBP3C RIMBP3B DNMBP	3.24e-04	86	129	5	IPR011511
Domain	-	CHIT1 OVGP1	4.67e-04	5	129	2	3.10.50.10
Domain	Chitinase_insertion	CHIT1 OVGP1	4.67e-04	5	129	2	IPR029070
Domain	FN3	OBSCN RIMBP3 PTPRO RIMBP3C RIMBP3B TNXB PRLR	4.69e-04	199	129	7	PS50853
Domain	ARM-like	PPP4R1L USP9Y ECPAS SCYL2 ELMO3 NF1 PLAA TNPO3	5.81e-04	270	129	8	IPR011989
Domain	ARM-type_fold	DOCK1 USP9Y ECPAS SCYL2 ELMO3 NF1 PLAA RNPEP TNPO3	5.85e-04	339	129	9	IPR016024
Domain	FN3_dom	OBSCN RIMBP3 PTPRO RIMBP3C RIMBP3B TNXB PRLR	6.27e-04	209	129	7	IPR003961
Domain	-	EPPK1 EVPL	6.97e-04	6	129	2	3.90.1290.10
Domain	Glyco_hydro_18_chit_AS	CHIT1 OVGP1	6.97e-04	6	129	2	IPR001579
Domain	PH	ARHGAP42 DOK3 OBSCN PLEKHA6 ARHGEF40 ELMO3 OSBPL5 ACAP2	7.03e-04	278	129	8	SM00233
Domain	PH_DOMAIN	ARHGAP42 DOK3 OBSCN PLEKHA6 ARHGEF40 ELMO3 OSBPL5 ACAP2	7.20e-04	279	129	8	PS50003
Domain	PH_domain	ARHGAP42 DOK3 OBSCN PLEKHA6 ARHGEF40 ELMO3 OSBPL5 ACAP2	7.36e-04	280	129	8	IPR001849
Domain	Glyco_hydro18_cat	CHIT1 OVGP1	9.72e-04	7	129	2	IPR001223
Domain	Plectin	EPPK1 EVPL	9.72e-04	7	129	2	PF00681
Domain	Plectin_repeat	EPPK1 EVPL	9.72e-04	7	129	2	IPR001101
Domain	Glyco_hydro_18	CHIT1 OVGP1	9.72e-04	7	129	2	PF00704
Domain	Chitinase_II	CHIT1 OVGP1	9.72e-04	7	129	2	IPR011583
Domain	Glyco_18	CHIT1 OVGP1	9.72e-04	7	129	2	SM00636
Domain	CHITINASE_18	CHIT1 OVGP1	9.72e-04	7	129	2	PS01095
Domain	PLEC	EPPK1 EVPL	9.72e-04	7	129	2	SM00250
Domain	PTEN_C2	TNS1 TNS3	1.29e-03	8	129	2	PF10409
Domain	PTB	TNS1 TNS3	1.29e-03	8	129	2	IPR013625
Domain	PTEN_C2	TNS1 TNS3	1.29e-03	8	129	2	SM01326
Domain	PTB	TNS1 TNS3	1.29e-03	8	129	2	PF08416
Domain	C2_TENSIN	TNS1 TNS3	1.29e-03	8	129	2	PS51182
Domain	Tensin_lipid_phosphatase_dom	TNS1 TNS3	1.29e-03	8	129	2	IPR029023
Domain	Tensin_C2-dom	TNS1 TNS3	1.29e-03	8	129	2	IPR014020
Domain	Pkinase	BMP2K OBSCN RIPK4 MAP3K5 SCYL2 STK4 CDKL5 STK11 PRKCA	1.33e-03	381	129	9	PF00069
Domain	PPASE_TENSIN	TNS1 TNS3	1.65e-03	9	129	2	PS51181
Domain	FN3	OBSCN PTPRO RIMBP3C RIMBP3B TNXB PRLR	1.81e-03	185	129	6	SM00060
Domain	Prot_kinase_dom	BMP2K OBSCN RIPK4 MAP3K5 SCYL2 STK4 CDKL5 STK11 PRKCA ALK	2.11e-03	489	129	10	IPR000719
Domain	PROTEIN_KINASE_DOM	BMP2K OBSCN RIPK4 MAP3K5 SCYL2 STK4 CDKL5 STK11 PRKCA ALK	2.24e-03	493	129	10	PS50011
Domain	-	HSPA4L HSPA9	2.99e-03	12	129	2	2.60.34.10
Domain	HSP70_peptide-bd	HSPA4L HSPA9	2.99e-03	12	129	2	IPR029047
Domain	Peptidase_M1	LVRN RNPEP	2.99e-03	12	129	2	IPR001930
Domain	TYR_PHOSPHATASE_dom	RNGTT MTMR4 STYX PTPRO	3.11e-03	87	129	4	IPR000387
Domain	TYR_PHOSPHATASE_2	RNGTT MTMR4 STYX PTPRO	3.11e-03	87	129	4	PS50056
Domain	Ser/Thr_kinase_AS	BMP2K OBSCN RIPK4 MAP3K5 STK4 CDKL5 STK11 PRKCA	3.39e-03	357	129	8	IPR008271
Domain	S_TKc	BMP2K OBSCN MAP3K5 SCYL2 STK4 CDKL5 STK11 PRKCA	3.50e-03	359	129	8	SM00220
Domain	Peptidase_M1_N	LVRN RNPEP	3.51e-03	13	129	2	IPR014782
Domain	-	HSPA4L HSPA9	3.51e-03	13	129	2	1.20.1270.10
Domain	Heat_shock_70_CS	HSPA4L HSPA9	3.51e-03	13	129	2	IPR018181
Domain	HSP70_C	HSPA4L HSPA9	3.51e-03	13	129	2	IPR029048
Domain	Peptidase_M1	LVRN RNPEP	3.51e-03	13	129	2	PF01433
Domain	Ig-like_fold	OBSCN LILRA6 RIMBP3 SHANK2 PTPRO VCAN RIMBP3C RIMBP3B TNXB PRLR TREML2 LILRB4	3.59e-03	706	129	12	IPR013783
Domain	PROTEIN_KINASE_ST	BMP2K OBSCN RIPK4 MAP3K5 STK4 CDKL5 STK11 PRKCA	3.68e-03	362	129	8	PS00108
Domain	Kinase-like_dom	BMP2K OBSCN RIPK4 MAP3K5 SCYL2 STK4 CDKL5 STK11 PRKCA ALK	4.40e-03	542	129	10	IPR011009
Domain	HEAT	PPP4R1L ECPAS SCYL2	4.44e-03	48	129	3	PF02985
Domain	PROTEIN_KINASE_ATP	BMP2K OBSCN RIPK4 MAP3K5 STK4 CDKL5 STK11 PRKCA ALK	4.61e-03	459	129	9	PS00107
Domain	PH	ARHGAP42 DOK3 OBSCN PLEKHA6 OSBPL5 ACAP2	5.18e-03	229	129	6	PF00169
Domain	SH2	INPP5D SOCS5 TNS1 TNS3	5.29e-03	101	129	4	PF00017
Domain	HSP70	HSPA4L HSPA9	5.33e-03	16	129	2	PF00012
Domain	C2_dom	SYT2 CC2D2A PRKCA TNS1 TNS3	5.64e-03	164	129	5	IPR000008
Domain	HSP70_2	HSPA4L HSPA9	6.02e-03	17	129	2	PS00329
Domain	HSP70_1	HSPA4L HSPA9	6.02e-03	17	129	2	PS00297
Domain	HSP70_3	HSPA4L HSPA9	6.02e-03	17	129	2	PS01036
Domain	Hsp_70_fam	HSPA4L HSPA9	6.74e-03	18	129	2	IPR013126
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGB1_TO_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY	DOCK1 ELMO3 RAC1	3.53e-06	5	101	3	M48982
Pubmed	RapGAPs in brain: multipurpose players in neuronal Rap signalling.	SIPA1L3 SIPA1L1 SIPA1L2	5.34e-08	3	132	3	20576033
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	2.13e-07	4	132	3	19091768
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDST1 EPPK1 BCAS3 SIPA1L3 OBSCN C15orf39 POM121C RYR1 MAP3K5 ARHGEF40 SHANK2 FURIN CHD5 OSBPL5 DISP2 SIPA1L2 DNMBP TNPO3	2.15e-07	1105	132	18	35748872
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPI MYH9 HSPA4L BCAS3 SIPA1L3 POR PLEKHA6 LACTB STK4 CDKL5 NF1 SHANK2 RNPEP SIPA1L1 VCAN PRKCA SIPA1L2 TNS1 HSPA9 RAC1	4.88e-07	1431	132	20	37142655
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	5.31e-07	5	132	3	17855024
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KDM3A MLEC CACHD1 ECPAS HEPH GPR107 NUP155 CHD5 OSBPL5 DNMBP ACAP2 EXOSC7	9.06e-07	529	132	12	14621295
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	STK4 PIEZO2 RAC1	2.95e-06	8	132	3	34112781
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF536 PCDHA9 ADAMTS3 ECPAS ENTPD4 SALL2	2.98e-06	104	132	6	9205841
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	A2M RNGTT MLEC HSPA4L EVPL ECPAS MTMR4 NUP155 STYX PTPRO PEX19 LRP1 SIPA1L2 TNPO3 TNS3	4.70e-06	974	132	15	28675297
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	DOCK1 PCDHA9 AIRE RYR1 CDKL5 SHANK2 SEC24B OSBPL5 VPS13A	4.98e-06	329	132	9	17474147
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	GPI MYH9 MLEC HSPA4L ECPAS ABHD14B GPR107 PLAA NUP155 RNPEP CCDC47 SELENOI HSPA9 MVD	6.72e-06	878	132	14	37223481
Pubmed	Association of polymorphisms in the LRP1 and A2M genes with Alzheimer's disease in the northern Chinese Han population.	A2M LRP1	1.43e-05	2	132	2	23186781
Pubmed	Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions.	A2M ALK	1.43e-05	2	132	2	28705706
Pubmed	Genetic defects of iron transport.	SLC11A2 HEPH	1.43e-05	2	132	2	782924
Pubmed	Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.	UGT3A1 UGT3A2	1.43e-05	2	132	2	22621930
Pubmed	Rac1 is a downstream effector of PKCα in structural synaptic plasticity.	PRKCA RAC1	1.43e-05	2	132	2	32019972
Pubmed	Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.	TNS1 TNS3	1.43e-05	2	132	2	35954177
Pubmed	Oviductal Glycoprotein 1 Promotes Hypertension by Inducing Vascular Remodeling Through an Interaction With MYH9.	MYH9 OVGP1	1.43e-05	2	132	2	36172862
Pubmed	Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in Neurofibromatosis 1 mutant mice.	NF1 ALK	1.43e-05	2	132	2	28057529
Pubmed	Upregulation of phagocytic clearance of apoptotic cells by autoimmune regulator.	AIRE RAC1	1.43e-05	2	132	2	20407862
Pubmed	Rac1 is essential for basement membrane-dependent epiblast survival.	DOCK1 RAC1	1.43e-05	2	132	2	20457815
Pubmed	Regulation of Rac1 activation by the low density lipoprotein receptor-related protein.	LRP1 RAC1	1.43e-05	2	132	2	12499359
Pubmed	Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.	A2M LRP1	1.43e-05	2	132	2	11823454
Pubmed	Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.	LRP1 PRKCA	1.43e-05	2	132	2	15272003
Pubmed	Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing.	MYH9 RAC1	1.43e-05	2	132	2	25544611
Pubmed	Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells.	ISG15 RAC1	1.43e-05	2	132	2	30765861
Pubmed	Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.	A2M LRP1	1.43e-05	2	132	2	8485155
Pubmed	Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos.	GPI HEPH	1.43e-05	2	132	2	5111764
Pubmed	Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.	MYH9 ALK	1.43e-05	2	132	2	12800156
Pubmed	Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.	SIPA1L3 SIPA1L1	1.43e-05	2	132	2	26364583
Pubmed	The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.	FURIN LRP1	1.43e-05	2	132	2	8546712
Pubmed	NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.	A2M LRP1	1.43e-05	2	132	2	10652313
Pubmed	Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner.	SLC11A2 PRKCA	1.43e-05	2	132	2	30423260
Pubmed	Dok-3 plays a nonredundant role in negative regulation of B-cell activation.	INPP5D DOK3	1.43e-05	2	132	2	17363732
Pubmed	Activation of Rac1 by a Crk SH3-binding protein, DOCK180.	DOCK1 RAC1	1.43e-05	2	132	2	9808620
Pubmed	Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling.	A2M LRP1	1.43e-05	2	132	2	20048078
Pubmed	Pharmacological inhibition of Anaplastic Lymphoma Kinase rescues spatial memory impairments in Neurofibromatosis 1 mutant mice.	NF1 ALK	1.43e-05	2	132	2	28629962
Pubmed	Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1.	NF1 RAC1	1.43e-05	2	132	2	32471868
Pubmed	Silencing of dedicator of cytokinesis (DOCK180) obliterates pregnancy by interfering with decidualization due to blockage of nuclear entry of autoimmune regulator (AIRE).	DOCK1 AIRE	1.43e-05	2	132	2	29516628
Pubmed	α-2-Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts.	A2M LRP1	1.43e-05	2	132	2	30479021
Pubmed	Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9.	MYH9 OVGP1	1.43e-05	2	132	2	16567366
Pubmed	DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation.	DOCK1 RAC1	1.43e-05	2	132	2	29432733
Pubmed	Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.	DOCK1 RAC1	1.43e-05	2	132	2	25118935
Pubmed	Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese.	A2M LRP1	1.43e-05	2	132	2	16040006
Pubmed	Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.	FURIN LRP1	1.43e-05	2	132	2	2112085
Pubmed	Non-muscle myosin IIA is post-translationally modified by interferon-stimulated gene 15 in breast cancer cells.	MYH9 ISG15	1.43e-05	2	132	2	30529400
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK1 ELMO3 RAC1	1.49e-05	13	132	3	21930703
Pubmed	A human MAP kinase interactome.	DOCK1 MYH9 ARID4B EVPL PLEKHA6 POM121C MAP3K5 POM121 TNS1 RAC1	1.77e-05	486	132	10	20936779
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.89e-05	14	132	3	17662146
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	DOCK1 GPI HSPA4L ECPAS HSPA9	2.35e-05	89	132	5	27034005
Pubmed	Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.	GPI MLEC NIPSNAP3B OBSCN POR CRAT LACTB GSTK1 ISG15 LRP1 HSPA9 YIPF3 RAC1	2.51e-05	859	132	13	31536960
Pubmed	A protein interaction landscape of breast cancer.	EPPK1 BMP2K HSPA4L SIPA1L3 ECPAS STK11 PLAA ISG15 LRP1 EXOSC7 TNPO3	3.20e-05	634	132	11	34591612
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	DAZL SCYL2 NF1 SHANK2 STYX LRP1 ALK HSPA9 TNS3	3.44e-05	420	132	9	28065597
Pubmed	Defining the membrane proteome of NK cells.	GPI KDM3A MYH9 SLC11A2 MLEC POR ECPAS NF1 NUP155 GSTK1 CCDC47 FURIN CHD5 OSBPL5 ACAP2	3.92e-05	1168	132	15	19946888
Pubmed	Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice.	NDST1 LRP1	4.28e-05	3	132	2	23846497
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121C POM121	4.28e-05	3	132	2	30802453
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121C POM121	4.28e-05	3	132	2	35507432
Pubmed	Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.	LRP1 PRKCA	4.28e-05	3	132	2	17974965
Pubmed	Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane.	POM121 NUP155	4.28e-05	3	132	2	20974814
Pubmed	Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.	DOCK1 RAC1	4.28e-05	3	132	2	22080864
Pubmed	The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3.	DOCK1 RAC1	4.28e-05	3	132	2	20237902
Pubmed	PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180/Rac1 pathway.	DOCK1 RAC1	4.28e-05	3	132	2	27052191
Pubmed	Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3.	INPP5D DOK3	4.28e-05	3	132	2	14993273
Pubmed	Elmo1 helps dock180 to regulate Rac1 activity and cell migration of ovarian cancer.	DOCK1 RAC1	4.28e-05	3	132	2	24819662
Pubmed	An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling.	DOCK1 RAC1	4.28e-05	3	132	2	18768751
Pubmed	Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes.	A2M LRP1	4.28e-05	3	132	2	16402284
Pubmed	Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.	A2M LRP1	4.28e-05	3	132	2	12394648
Pubmed	PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity.	PRKCA RAC1	4.28e-05	3	132	2	22469974
Pubmed	Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation.	MYH9 INPP5D	4.28e-05	3	132	2	35493485
Pubmed	PH domain of ELMO functions in trans to regulate Rac activation via Dock180.	DOCK1 RAC1	4.28e-05	3	132	2	15247908
Pubmed	Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.	A2M LRP1	4.28e-05	3	132	2	10880251
Pubmed	A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.	INPP5D DOK3	4.28e-05	3	132	2	23962980
Pubmed	Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.	HSPA9 MVD	4.28e-05	3	132	2	12646231
Pubmed	Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines.	A2M LRP1	4.28e-05	3	132	2	20568116
Pubmed	Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis.	SLC11A2 HEPH	4.28e-05	3	132	2	12949720
Pubmed	The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.	DOCK1 RAC1	4.28e-05	3	132	2	25586182
Pubmed	ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.	A2M FURIN	4.28e-05	3	132	2	10373500
Pubmed	Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.	NF1 RAC1	4.28e-05	3	132	2	18089636
Pubmed	The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.	A2M LRP1	4.28e-05	3	132	2	12194978
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	GPI RNGTT MLEC C15orf39 POM121C SCYL2 STK4 POM121 NF1 SIPA1L1 SEC24B MINDY4 ACAP2 EXOSC7 TNPO3 RAC1	4.30e-05	1321	132	16	27173435
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	GPI MYH9 RNGTT BMP2K POR CDKL5 NUP155 FURIN SEC24B VPS13A PRRC1 HSPA9	4.30e-05	777	132	12	35844135
Pubmed	TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.	MYH9 SCYL2 HSPA9	4.95e-05	19	132	3	38515377
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ARID4B PLEKHA6 POM121C RYR1 ZIC1 SHANK2 VPS13A FBXO7 TNS1 TNXB	5.18e-05	552	132	10	10737800
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	HSPA4L BCAS3 PLEKHA6 NF1 SHANK2 SIPA1L1 PRKCA SIPA1L2	5.70e-05	347	132	8	17114649
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	A2M GPI MYH9 EPPK1 ECPAS PLAA NUP155 GSTK1 CCDC47 LRP1 PRKCA EXOSC7 HSPA9 MVD TNS3 RAC1	6.43e-05	1367	132	16	32687490
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	HSPA4L POR CACHD1 ECPAS POM121C ARHGEF40 POM121 PLAA NUP155 CCDC47 SEC24B TNPO3 YIPF3	6.45e-05	942	132	13	31073040
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	MYH9 RNGTT BMP2K INPP5D DOK3 USP9Y HSPA9	7.39e-05	266	132	7	19380743
Pubmed	Kir2.1 Interaction with Stk38 Promotes Invasion and Metastasis of Human Gastric Cancer by Enhancing MEKK2-MEK1/2-ERK1/2 Signaling.	EPPK1 RNPEP HSPA9	7.81e-05	22	132	3	29549164
Pubmed	Activation and association of the Tec tyrosine kinase with the human prolactin receptor: mapping of a Tec/Vav1-receptor binding site.	PRLR RAC1	8.54e-05	4	132	2	11328862
Pubmed	The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.	DOCK1 RAC1	8.54e-05	4	132	2	18596235
Pubmed	Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.	MYH9 STK4	8.54e-05	4	132	2	25133611
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121C POM121	8.54e-05	4	132	2	17900573
Pubmed	A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.	DOCK1 RAC1	8.54e-05	4	132	2	15723800
Pubmed	Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1.	PRKCA RAC1	8.54e-05	4	132	2	19147498
Pubmed	CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.	DOCK1 ELMO3	8.54e-05	4	132	2	11595183
Pubmed	Interaction of protein kinase C isozymes with Rho GTPases.	PRKCA RAC1	8.54e-05	4	132	2	11284700
Pubmed	Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.	A2M LRP1	8.54e-05	4	132	2	18706476
Pubmed	Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.	A2M LRP1	8.54e-05	4	132	2	20637261
Pubmed	MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation.	PRKCA RAC1	8.54e-05	4	132	2	24841200
Pubmed	Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.	INPP5D DOK3	8.54e-05	4	132	2	19682241
Interaction	KIT interactions	INPP5D STYX PTPRO SOCS5 PRKCA TNS1 ALK TNS3	1.51e-06	125	130	8	int:KIT
Interaction	DAB2 interactions	MYH9 BMP2K INPP5D NUP155 ISG15 SEC24B LRP1 RAC1	3.53e-06	140	130	8	int:DAB2
Interaction	GRIN1 interactions	DOCK1 MYH9 CDKL5 NF1 SHANK2 LRP1 PRKCA RAC1	7.16e-06	154	130	8	int:GRIN1
Cytoband	5p13.2	UGT3A1 UGT3A2 PRLR	1.01e-04	31	133	3	5p13.2
Cytoband	7q11.2	POR POM121C	4.50e-04	11	133	2	7q11.2
GeneFamily	Chitinases	CHIT1 OVGP1	5.64e-04	7	95	2	816
GeneFamily	Phosphoinositide phosphatases	INPP5D MTMR4 FIG4	6.24e-04	32	95	3	1079
GeneFamily	EF-hand domain containing\|Plakins	EPPK1 EVPL	7.49e-04	8	95	2	939
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	TNS1 TNS3	7.49e-04	8	95	2	837
GeneFamily	SH2 domain containing	INPP5D SOCS5 TNS1 TNS3	1.98e-03	101	95	4	741
GeneFamily	Heat shock 70kDa proteins	HSPA4L HSPA9	3.53e-03	17	95	2	583
GeneFamily	Aminopeptidases\|CD molecules	LVRN RNPEP	3.53e-03	17	95	2	104
GeneFamily	Atypical dual specificity phosphatases	RNGTT STYX	3.96e-03	18	95	2	896
Coexpression	GSE3720_LPS_VS_PMA_STIM_VD2_GAMMADELTA_TCELL_UP	FBXO11 CHIT1 PIEZO2 OVGP1 NF1 NUP155 CDH17	6.25e-06	137	132	7	M6346
Coexpression	GSE34156_UNTREATED_VS_6H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_UP	SLC43A2 DOK3 LILRA6 CACHD1 VCAN TNS3 RAC1 LILRB4	7.34e-06	197	132	8	M8672
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 MAP3K5 PIEZO2 VCAN LRP1 PRKCA	1.28e-07	194	133	8	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 MAP3K5 PIEZO2 VCAN LRP1 PRKCA	1.28e-07	194	133	8	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MLEC BMP2K INPP5D MGLL ARHGEF40 CCDC47 LRP1 ACAP2	1.33e-07	195	133	8	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 MAP3K5 PIEZO2 VCAN LRP1 PRKCA	1.33e-07	195	133	8	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	BAL-Severe-Myeloid-MoAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC43A2 LACTB ISG15 VCAN LRP1 TNS3 RAC1 LILRB4	1.61e-07	200	133	8	43ec6732cc255d533170ebf95d282e503606dcc6
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Control / Condition, Lineage and Cell class	A2M CHIT1 STK11 ARHGEF40 TNS1 ALK LILRB4	9.47e-07	174	133	7	4c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGAP42 ZNF536 MYH9 LMCD1 MAMLD1 VCAN TNS1	1.43e-06	185	133	7	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	DOK3 LACTB FIG4 LRP1 SIPA1L2 TNS3 LILRB4	1.89e-06	193	133	7	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 MAP3K5 VCAN LRP1 PRKCA	2.02e-06	195	133	7	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	Monocytes-NUPR1+_Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	A2M SLC43A2 LILRA6 MGLL PTPRO TNS3 LILRB4	2.02e-06	195	133	7	5e12201ce7ba912e7faa123ca200e609252ba288
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	SLC43A2 DOK3 FIG4 VCAN LRP1 SIPA1L2 TNS3	2.02e-06	195	133	7	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 PIEZO2 VCAN LRP1 PRKCA	2.17e-06	197	133	7	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 PIEZO2 VCAN LRP1 PRKCA	2.17e-06	197	133	7	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 PIEZO2 VCAN LRP1 PRKCA	2.17e-06	197	133	7	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 BCAS3 SIPA1L3 NF1 SHANK2 SIPA1L1 PRKCA	2.24e-06	198	133	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	COPD-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	A2M MAMLD1 CHIT1 SIPA1L1 DNMBP TNS1 LILRB4	2.32e-06	199	133	7	1cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCell	10x5'-Liver-Myeloid_Monocytic-Classical_monocytes\|Liver / Manually curated celltypes from each tissue	SLC43A2 DOK3 LILRA6 VCAN LRP1 RAC1 LILRB4	2.32e-06	199	133	7	46491e8e76aa4d7ada036946f93cf71609c85462
ToppCell	IPF-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	A2M MAMLD1 CHIT1 SIPA1L1 TNS1 TNS3 LILRB4	2.32e-06	199	133	7	3c2b362d5e824e1a04830e70352f8818de984174
ToppCell	Mild-Myeloid-Macrophages-FCN1-SPP1+\|Mild / Condition, Lineage, Cell class and cell subclass	A2M MGLL LACTB LRP1 TNS1 TNS3 LILRB4	2.39e-06	200	133	7	e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCell	BAL-Severe-Myeloid-MoAM\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LACTB ISG15 VCAN LRP1 TNS3 RAC1 LILRB4	2.39e-06	200	133	7	60bf9f9d4899245463707016e51cd7243f6405b4
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	CHIT1 RNPEP VCAN LRP1 RIMBP3C LILRB4	1.00e-05	164	133	6	057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCell	droplet-Fat-Scat-18m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK3 LILRA6 RNPEP PTPRO VCAN LILRB4	1.04e-05	165	133	6	015f8f408d7fd17292defe63fa02b16eed642dfb
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 LILRA6 RNPEP ISG15 PTPRO LILRB4	1.11e-05	167	133	6	d62d5dec30d006a9cc8f3bc5ccc578e10f105027
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 LILRA6 RNPEP ISG15 PTPRO LILRB4	1.15e-05	168	133	6	3d8c431a3c8899383212fe6a7627889c40c5f3ef
ToppCell	facs-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK3 LILRA6 RNPEP PTPRO VCAN LILRB4	1.19e-05	169	133	6	05b138511039f1255a5f647040b1b9bdf222bd52
ToppCell	facs-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK3 LILRA6 RNPEP PTPRO VCAN LILRB4	1.19e-05	169	133	6	bf0a97f53d6e3f9ffeaeae0402b010c49a6cccb7
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	CIB3 LMCD1 MGLL STK4 IDO2 PIEZO2	1.27e-05	171	133	6	ce290930385cac35dbd21a5e91cf0f93cf3e99f8
ToppCell	droplet-Lung-nan-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK3 LILRA6 RNPEP PTPRO VCAN LILRB4	1.31e-05	172	133	6	35d09640d5b04fa0bbb1b40d4b8f97da587a5046
ToppCell	droplet-Lung-nan-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK3 LILRA6 RNPEP PTPRO VCAN LILRB4	1.31e-05	172	133	6	98cb64e2a768908105701a7a5b58f336036250fd
ToppCell	COVID-19-kidney-PEC\|kidney / Disease (COVID-19 only), tissue and cell type	ZNF536 ADAMTS3 MAP3K5 VCAN SIPA1L2 TNS1	1.31e-05	172	133	6	36a96714a0eb6ac438648135336c9791881ddadb
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 LILRA6 ISG15 PTPRO VCAN LILRB4	1.50e-05	176	133	6	8f9d2a763b79cafe26dcbf3dba980d473a0b9873
ToppCell	droplet-Lung-1m-Hematologic-myeloid-classical_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 LILRA6 ISG15 PTPRO VCAN LILRB4	1.50e-05	176	133	6	3b5d12d5c22e32fbe80c3716ff14a7ae5769c165
ToppCell	Control-Myeloid-MoAM2,_CCL18\|Myeloid / Condition, Lineage and Cell class	A2M CHIT1 ARHGEF40 TNS1 ALK LILRB4	1.54e-05	177	133	6	470f54fe2b21c7350ea471e02039461a3808f700
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 RNPEP PTPRO VCAN LRP1 LILRB4	1.65e-05	179	133	6	66afd54428e6dcadc3e341faecfde42be4fb5905
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOK3 RNPEP PTPRO VCAN LRP1 LILRB4	1.65e-05	179	133	6	fa58fa0901eadb170e3d2facb2a3d8c5e624329a
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Macrophage\|lymph-node_spleen / Manually curated celltypes from each tissue	A2M MGLL CHIT1 LRP1 TNS1 LILRB4	1.65e-05	179	133	6	b4430f633711cecf793e8e76e766a66ff1eff473
ToppCell	21-Trachea-Mesenchymal-Airway_Smooth_Muscle\|Trachea / Age, Tissue, Lineage and Cell class	ANO4 A2M ZNF536 LMCD1 HEPH PIEZO2	1.92e-05	184	133	6	86a96cd88e50eacad1f0badfbbf6dc626f41725e
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B AIRE C15orf39 CHRNB1 RYR1 PRLR	1.98e-05	185	133	6	238938a4682b44e88a30b86b13af4feeabe9553d
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANO4 ARHGAP42 ZNF536 LMCD1 LRP1 TNXB	1.98e-05	185	133	6	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA6 ARHGEF40 VCAN LRP1 PRKCA TNXB	2.04e-05	186	133	6	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA6 ARHGEF40 VCAN LRP1 PRKCA TNXB	2.04e-05	186	133	6	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DENND5B BMP2K SIPA1L3 SIPA1L1 DNMBP TNS3	2.11e-05	187	133	6	af1327559f7e01bec070881cae52834917c3da65
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	A2M LILRA6 VCAN LRP1 CC2D2A LILRB4	2.17e-05	188	133	6	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	A2M LILRA6 VCAN LRP1 CC2D2A LILRB4	2.17e-05	188	133	6	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.24e-05	189	133	6	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 PIEZO2 LRP1 PRKCA	2.30e-05	190	133	6	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.30e-05	190	133	6	2e592323085ba9c019d678ac2a784462ab470ed9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 PIEZO2 LRP1 PRKCA	2.30e-05	190	133	6	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.30e-05	190	133	6	445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	DENND5B BMP2K SIPA1L3 SIPA1L1 DNMBP TNS3	2.30e-05	190	133	6	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.37e-05	191	133	6	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.37e-05	191	133	6	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 VCAN LRP1 PRKCA	2.37e-05	191	133	6	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ANO4 ARHGAP42 A2M ZNF536 LMCD1 HEPH	2.44e-05	192	133	6	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	A2M LMCD1 MAMLD1 PIEZO2 TNS1 TNXB	2.59e-05	194	133	6	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAP3K5 PIEZO2 VCAN LRP1	2.67e-05	195	133	6	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC11A2 BMP2K DOK3 LRP1 SIPA1L2 TNS3	2.67e-05	195	133	6	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LILRA6 LACTB ISG15 VCAN PRLR LILRB4	2.67e-05	195	133	6	9c9634906168239cf978adb398787692437bf9e7
ToppCell	NS-moderate-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LILRA6 LACTB ISG15 VCAN PRLR LILRB4	2.67e-05	195	133	6	d87c83d2d421c9291d0a10bc9db850e9fb337667
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 BCAS3 SIPA1L3 SHANK2 SIPA1L1 PRKCA	2.74e-05	196	133	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M PIEZO2 VCAN LRP1 PRKCA	2.74e-05	196	133	6	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	A2M SLC43A2 BMP2K LILRA6 TNS3 LILRB4	2.74e-05	196	133	6	ab0a8f5f388c9794d7f41f99fb0a5f2fd6fff6b3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 MAP3K5 PIEZO2 TNXB	2.74e-05	196	133	6	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 VCAN LRP1 PRKCA	2.74e-05	196	133	6	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M MAMLD1 VCAN LRP1 PRKCA	2.74e-05	196	133	6	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 A2M PIEZO2 VCAN LRP1 PRKCA	2.74e-05	196	133	6	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	normal_Lymph_Node-Myeloid_cells-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	A2M MGLL CHIT1 LRP1 TNS1 LILRB4	2.82e-05	197	133	6	d8dc65b580191827ab6bbad5e29f0089419ebaef
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ANO4 A2M ZNF536 LMCD1 VCAN TNXB	2.82e-05	197	133	6	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M MGLL PTPRO LRP1 TNS3 LILRB4	2.90e-05	198	133	6	579a22199643440b98e381147779ced630d4ed66
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC43A2 DOK3 C15orf39 ARHGEF40 VCAN LRP1	2.90e-05	198	133	6	06201b34d3e38f22c93b759511f7b376504bac06
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANO4 ZNF536 ZIC1 VCAN CHD5 CDH17	2.90e-05	198	133	6	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	Mild-Myeloid-Macrophages-FCN1_high\|Mild / Condition, Lineage, Cell class and cell subclass	SLC43A2 LILRA6 LACTB VCAN PRLR LILRB4	2.90e-05	198	133	6	17aab4dc3b2cd6eb7dda77dd51bdc20490fcfe19
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	A2M MGLL CHIT1 LRP1 TNS1 LILRB4	2.90e-05	198	133	6	c08018f099a381a66993cb60288954a6e47f105f
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	A2M MGLL CHIT1 LRP1 TNS1 LILRB4	2.90e-05	198	133	6	27cc7f786fb8cb230589d762a4e51b46265c1f19
ToppCell	normal_Lymph_Node-Myeloid_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	A2M MGLL CHIT1 LRP1 TNS1 LILRB4	2.90e-05	198	133	6	6b956073898192b1c6c8da66416b6a9b20d28a82
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC43A2 DOK3 C15orf39 ARHGEF40 VCAN LRP1	2.90e-05	198	133	6	1ca91559fef231896e16180f5e050155c38f7cfa
ToppCell	10x5'-Liver-Myeloid_Monocytic\|Liver / Manually curated celltypes from each tissue	SLC43A2 DOK3 LILRA6 VCAN LRP1 LILRB4	2.90e-05	198	133	6	d0925948bf667545fb0b343e2fc80f7379e433e3
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAMLD1 LACTB SIPA1L1 SIPA1L2 DNMBP LILRB4	2.99e-05	199	133	6	951c2ea5af4756832c2adcec3ee70a7e36331a4e
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	A2M LILRA6 PTPRO LRP1 TNS1 TNS3	2.99e-05	199	133	6	fb63885273d906a85fef178d859d20a311eb8a72
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Transverse / Region, Cell class and subclass	A2M LILRA6 VCAN LRP1 SIPA1L2 PRLR	2.99e-05	199	133	6	facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell	Transverse-(6)_Macrophage-(61)_LYVE1_Macrophage\|Transverse / shred on region, Cell_type, and subtype	A2M LILRA6 VCAN LRP1 SIPA1L2 PRLR	2.99e-05	199	133	6	dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK1 BCAS3 SIPA1L3 NF1 SHANK2 PRKCA	2.99e-05	199	133	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Healthy_donor-Classical_Monocyte\|Healthy_donor / disease group, cell group and cell class (v2)	SLC43A2 C15orf39 LACTB ARHGEF40 VCAN LRP1	2.99e-05	199	133	6	af3a80dbf5e0306b80f420fd41f1aaed81fe9c46
ToppCell	Healthy/Control-Classical_Monocyte\|Healthy/Control / Disease group and Cell class	SLC43A2 C15orf39 LACTB ARHGEF40 VCAN LRP1	2.99e-05	199	133	6	4e8c7445d32fd2b7a50524dcd52141e76850c3df
ToppCell	343B-Fibroblasts-Fibroblast-G\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M LMCD1 HEPH PIEZO2 LRP1 TNXB	2.99e-05	199	133	6	f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell	343B-Fibroblasts-Fibroblast-G-\|343B / Donor, Lineage, Cell class and subclass (all cells)	A2M LMCD1 HEPH PIEZO2 LRP1 TNXB	2.99e-05	199	133	6	9c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCell	moderate-Myeloid-Non-resident_Macrophage\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SLC43A2 LACTB VCAN LRP1 TNS3 LILRB4	2.99e-05	199	133	6	614c1e788d89310e78984241977941beed8d12dc
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ADAMTS3 VCAN LRP1 MINDY4 TNS1 TNXB	3.07e-05	200	133	6	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	BAL-Severe-Myeloid\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	LACTB VCAN LRP1 TNS3 RAC1 LILRB4	3.07e-05	200	133	6	bb246c630b2fde1633b28838a5f087fdfb4bc4a5
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	A2M LMCD1 PIEZO2 VCAN LRP1 TNXB	3.07e-05	200	133	6	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	COVID-19-COVID-19_Severe-Others-RBC\|COVID-19_Severe / Disease, condition lineage and cell class	BMP2K IGLV4-60 STK11 FBXO7 TNS1 TNXB	3.07e-05	200	133	6	308f74e7e13ecc6d133c219c42cc8895a96644c8
ToppCell	mLN-Macrophage\|mLN / Region, Cell class and subclass	A2M LILRA6 VCAN LRP1 TNS1 LILRB4	3.07e-05	200	133	6	68d709afd226241e002dae6d6820bccd1cfd87a1
ToppCell	COVID-19-Myeloid\|COVID-19 / Condition, Lineage and Cell class	LACTB VCAN LRP1 TNS3 RAC1 LILRB4	3.07e-05	200	133	6	4c9e936b5e100c1a3ef10ea262febccf8226df9f
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	ANO4 ARHGAP42 LMCD1 VCAN LRP1 TNXB	3.07e-05	200	133	6	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	Severe_COVID-19-Myeloid-MoAM4\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	A2M MGLL CHIT1 LRP1 TNS1 TNS3	3.07e-05	200	133	6	30448a41ca64d6f0fedaff0b7a6670dd33cdf2c5
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM4-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	A2M MGLL CHIT1 LRP1 TNS1 TNS3	3.07e-05	200	133	6	4f481d87e30195365900acb5d50641a9e7b2f462
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	ANO4 ARHGAP42 LMCD1 VCAN LRP1 TNXB	3.07e-05	200	133	6	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	BAL-Severe-Myeloid-MoAM-MoAM4-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	A2M MGLL CHIT1 LRP1 TNS1 TNS3	3.07e-05	200	133	6	5490393c5f54748f912676e19b58bd1320415a06
ToppCell	metastatic_Lymph_Node-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	A2M GPI ISG15 LRP1 TNS3 LILRB4	3.07e-05	200	133	6	4758b96725699641b55a665533adf2d238032b09
ToppCell	mLN-(6)_Macrophage\|mLN / shred on region, Cell_type, and subtype	A2M LILRA6 VCAN LRP1 TNS1 LILRB4	3.07e-05	200	133	6	6dcba82a7d322102bae205543086e84c7655b3e0
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; MCF7; HT_HG-U133A	MAMLD1 EVPL RIPK4 GPR107 MAP3K5 STK4 SOCS5 PEX19 MVD	1.82e-06	196	129	9	6238_DN
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT_HG-U133A	NDST1 SALL2 NF1 VCAN LRP1 PRKCA ALOXE3 TNS1	1.36e-05	191	129	8	3823_DN
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	SLC11A2 FBXO11 ECPAS GPR107 STK4 NF1 PRKCA TNS1	1.41e-05	192	129	8	6664_DN
Drug	Niclosamide [50-65-7]; Down 200; 12.2uM; PC3; HT_HG-U133A	SIPA1L3 EVPL PLEKHA6 ECPAS MAP3K5 ARHGEF40 DNMBP TNS1	1.41e-05	192	129	8	4018_DN
Drug	Chrysin [480-40-0]; Down 200; 15.8uM; MCF7; HT_HG-U133A	BMP2K GPR107 MAP3K5 ZIC1 SHANK2 NUP155 PEX19 PRLR	1.47e-05	193	129	8	6485_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Down 200; 12.4uM; PC3; HT_HG-U133A	RNGTT BCAS3 SIPA1L3 EVPL CHRNB1 STK4 NF1 VCAN	1.58e-05	195	129	8	5112_DN
Drug	Methylhydantoin-5-(L) [40856-73-3]; Down 200; 35uM; MCF7; HT_HG-U133A	NDST1 RNGTT BMP2K FBXO11 STK11 SHANK2 SIPA1L1 FURIN	1.64e-05	196	129	8	5679_DN
Drug	Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; MCF7; HT_HG-U133A	DOCK1 RNGTT CRAT STK11 NF1 PEX19 DNMBP PRLR	1.64e-05	196	129	8	5318_UP
Drug	Glycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A	PCDHA9 C15orf39 PLEKHA6 ECPAS CRAT ENTPD4 CHRNB1 OVGP1	1.64e-05	196	129	8	3315_UP
Drug	Ebselen [60940-34-3]; Up 200; 14.6uM; HL60; HT_HG-U133A	NDST1 SIPA1L3 MAMLD1 PIEZO2 SIPA1L1 CHD5 ALOXE3 DNMBP	1.64e-05	196	129	8	2717_UP
Drug	Mycophenolic acid [24280-93-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	BMP2K PLEKHA6 ZIC1 OVGP1 SHANK2 SIPA1L1 PRKCA TNS3	1.70e-05	197	129	8	4137_DN
Drug	Bufexamac [2438-72-4]; Down 200; 18uM; PC3; HT_HG-U133A	SLC11A2 RNGTT SIPA1L3 PLEKHA6 OVGP1 CCDC47 PRKCA DNMBP	1.70e-05	197	129	8	5090_DN
Drug	arachidonyl trifluoromethyl ketone; Down 200; 10uM; MCF7; HG-U133A	NDST1 DNAH3 RNGTT CHRNB1 GPR107 FURIN PRKCA DHTKD1	1.76e-05	198	129	8	594_DN
Drug	Niflumic acid [4394-00-7]; Down 200; 14.2uM; MCF7; HT_HG-U133A	LMCD1 SIPA1L3 MAMLD1 PLEKHA6 STK4 NF1 FURIN VPS13A	1.76e-05	198	129	8	5490_DN
Drug	Nafronyl oxalate [3200-06-4]; Up 200; 8.4uM; PC3; HT_HG-U133A	A2M NF1 LRP1 PRKCA ALOXE3 ALK PRLR MVD	1.83e-05	199	129	8	6687_UP
Drug	Hippeastrine hydrobromide [22352-41-6]; Down 200; 10uM; PC3; HT_HG-U133A	DNAH3 PCDHA9 ENTPD4 MAP3K5 PLAA ALOXE3 DNMBP ALK	1.89e-05	200	129	8	3682_DN
Drug	CHAPS detergent	A2M ENPP7 POR MGLL RYR1 LRP1 PRLR	3.34e-05	158	129	7	CID000107670
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT_HG-U133A	EPPK1 RNGTT LMCD1 ENTPD4 STK4 VCAN PRKCA	6.62e-05	176	129	7	6886_UP
Drug	Rimexolone [49697-38-3]; Down 200; 10.8uM; HL60; HT_HG-U133A	KDM3A BMP2K HSPA4L ECPAS NF1 DNMBP TNS1	8.76e-05	184	129	7	2955_DN
Drug	AC1MMT9K	DAZL CHIT1 CHRNB1 FBXO7	1.02e-04	43	129	4	CID003266380
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	NDST1 DNAH3 HSPA4L LMCD1 ZIC1 MTO1 PRLR	1.07e-04	190	129	7	6945_DN
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; HL60; HT_HG-U133A	DENND5B ZNF536 SLC11A2 BMP2K VCAN DNMBP TNS1	1.07e-04	190	129	7	1342_UP
Drug	Methimazole [60-56-0]; Down 200; 35uM; PC3; HT_HG-U133A	RNGTT C15orf39 STK4 ARHGEF40 LRP1 ALOXE3 TNS1	1.11e-04	191	129	7	3815_DN
Drug	Nimesulide [51803-78-2]; Up 200; 13uM; MCF7; HT_HG-U133A	SIPA1L3 SYT2 STK11 ISG15 PRKCA TNS1 SEC14L5	1.18e-04	193	129	7	2275_UP
Drug	Ricinine [524-40-3]; Down 200; 24.4uM; HL60; HT_HG-U133A	NDST1 BMP2K SIPA1L3 CHRNB1 ELMO3 NF1 SIPA1L1	1.18e-04	193	129	7	2505_DN
Drug	Calycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A	DENND5B AIRE FBXO11 CRAT CHRNB1 RYR1 NF1	1.18e-04	193	129	7	2764_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	DOK3 FBXO11 ECPAS ARHGEF40 SIPA1L1 TNS1 LILRB4	1.22e-04	194	129	7	2523_DN
Drug	Bacampicillin hydrochloride [37661-08-8]; Down 200; 8uM; MCF7; HT_HG-U133A	PCDHA9 SIPA1L3 CRAT STK4 OVGP1 SOCS5 ALK	1.22e-04	194	129	7	3273_DN
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; PC3; HG-U133A	HSPA4L GPR107 NF1 FURIN SOCS5 EXOSC7 HSPA9	1.22e-04	194	129	7	1947_DN
Drug	Zomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A	EPPK1 SLC11A2 SIPA1L3 GPR107 NF1 SIPA1L1 EXOSC7	1.22e-04	194	129	7	3454_DN
Drug	radicicol; Up 200; 0.1uM; PC3; HG-U133A	RNGTT ARID4B HSPA4L OVGP1 SIPA1L1 SOCS5 PRKCA	1.26e-04	195	129	7	449_UP
Drug	Pentoxifylline [6493-05-6]; Up 200; 14.4uM; MCF7; HT_HG-U133A	DENND5B PCDHA9 NIPSNAP3B SIPA1L3 RYR1 STK4 TNS1	1.26e-04	195	129	7	2290_UP
Drug	Ebselen [60940-34-3]; Down 200; 14.6uM; MCF7; HT_HG-U133A	LMCD1 C15orf39 SCYL2 ELMO3 CCDC47 FURIN PRLR	1.26e-04	195	129	7	3458_DN
Drug	Cloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; PC3; HT_HG-U133A	DOCK1 SLC11A2 BCAS3 STK4 SALL2 FURIN LRP1	1.26e-04	195	129	7	2126_UP
Drug	Proadifen hydrochloride [62-68-0]; Up 200; 10.2uM; HL60; HT_HG-U133A	AIRE SYT2 CRAT STK11 NF1 ALOXE3 DNMBP	1.30e-04	196	129	7	2707_UP
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A	RNGTT LMCD1 SIPA1L3 VCAN SOCS5 PEX19 TNS1	1.30e-04	196	129	7	6582_DN
Drug	Fluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A	DOCK1 BMP2K SIPA1L3 C15orf39 MAP3K5 STK4 FURIN	1.30e-04	196	129	7	7348_DN
Drug	Aminophylline [317-34-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	EPPK1 SLC11A2 RNGTT POR STK11 FURIN TNS1	1.30e-04	196	129	7	6295_DN
Drug	Flucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	NIPSNAP3B SHANK2 VCAN ALOXE3 ALK PRLR SEC14L5	1.30e-04	196	129	7	5527_UP
Drug	Procarbazine hydrochloride [366-70-1]; Down 200; 15.6uM; MCF7; HT_HG-U133A	NDST1 RNGTT BMP2K LMCD1 ELMO3 NF1 PLAA	1.30e-04	196	129	7	3533_DN
Drug	Betulin [473-98-3]; Down 200; 9uM; HL60; HT_HG-U133A	DENND5B SLC11A2 BMP2K SIPA1L3 SIPA1L1 DNMBP MVD	1.30e-04	196	129	7	2952_DN
Drug	estradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A	ZNF536 SLC11A2 ENTPD4 STK11 NF1 VCAN LILRB4	1.30e-04	196	129	7	1182_DN
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	NDST1 BMP2K ARHGEF40 NF1 PTPRO ALOXE3 PRLR	1.30e-04	196	129	7	5461_UP
Drug	Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; MCF7; HT_HG-U133A	GPR107 STK11 ELMO3 NF1 ISG15 TNPO3 TNS3	1.30e-04	196	129	7	5338_UP
Drug	estradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A	BMP2K SIPA1L3 PLEKHA6 CHRNB1 RYR1 OVGP1 PRLR	1.30e-04	196	129	7	6928_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; PC3; HT_HG-U133A	DOCK1 NDST1 LMCD1 SIPA1L3 GPR107 STK4 TNS1	1.34e-04	197	129	7	4461_DN
Drug	PHA-00767505E [723337-45-9]; Down 200; 10uM; PC3; HT_HG-U133A	PLEKHA6 GPR107 STK4 MLN TNS1 TNPO3 HSPA9	1.34e-04	197	129	7	6545_DN
Drug	Althiazide [5588-16-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A	AIRE FBXO11 SYT2 PLEKHA6 ISG15 VCAN CHD5	1.34e-04	197	129	7	6829_UP
Drug	Flecainide acetate [54143-56-5]; Down 200; 8.4uM; HL60; HT_HG-U133A	DOK3 AIRE STK4 NF1 SIPA1L1 FURIN ALOXE3	1.34e-04	197	129	7	2557_DN
Drug	nifedipine; Up 200; 10uM; MCF7; HG-U133A	NDST1 SLC11A2 ELMO3 NF1 CHD5 ALK TREML2	1.34e-04	197	129	7	335_UP
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	NDST1 DNAH3 MAP3K5 STK11 NF1 SHANK2 MVD	1.34e-04	197	129	7	6271_UP
Drug	Pyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A	SIPA1L3 ENTPD4 GPR107 MAP3K5 ELMO3 SALL2 DNMBP	1.34e-04	197	129	7	7171_DN
Drug	Viomycin sulfate [37883-00-4]; Up 200; 5.2uM; MCF7; HT_HG-U133A	PCDHA9 LMCD1 FBXO11 EVPL ENTPD4 NF1 DNMBP	1.34e-04	197	129	7	7036_UP
Drug	Methylatropine nitrate [52-88-0]; Up 200; 11uM; MCF7; HT_HG-U133A	A2M PCDHA9 SIPA1L3 ECPAS HEPH CHRNB1 TNS1	1.38e-04	198	129	7	6495_UP
Drug	Iobenguane sulfate; Down 200; 10.8uM; PC3; HT_HG-U133A	DNAH3 SLC11A2 BMP2K C15orf39 EVPL NF1 TNS1	1.38e-04	198	129	7	7299_DN
Drug	Altretamine [654-05-6]; Down 200; 19uM; MCF7; HT_HG-U133A	SLC11A2 RNGTT BMP2K ENTPD4 GPR107 VPS13A PRLR	1.38e-04	198	129	7	5688_DN
Drug	Levamisole hydrochloride [16595-80-5]; Up 200; 16.6uM; PC3; HT_HG-U133A	NDST1 AIRE STK4 SHANK2 FURIN LRP1 SEC14L5	1.38e-04	198	129	7	2094_UP
Drug	Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PCDHA9 EPPK1 MAMLD1 PLEKHA6 NF1 SIPA1L1 SOCS5	1.38e-04	198	129	7	5524_DN
Drug	Paromomycin sulfate [1263-89-4]; Up 200; 5.6uM; HL60; HT_HG-U133A	NDST1 DNAH3 RNGTT MAMLD1 CRAT STK11 ALOXE3	1.38e-04	198	129	7	3017_UP
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; HL60; HT_HG-U133A	SLC11A2 BMP2K ECPAS SCYL2 STK4 NF1 SIPA1L1	1.38e-04	198	129	7	1313_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; PC3; HT_HG-U133A	RNGTT BMP2K SIPA1L3 OVGP1 SHANK2 VCAN LRP1	1.38e-04	198	129	7	4576_DN
Drug	nordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A	NIPSNAP3B INPP5D CHRNB1 NF1 VCAN TNS1 SEC14L5	1.38e-04	198	129	7	5220_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	PCDHA9 EPPK1 SIPA1L3 GPR107 STK11 SIPA1L1 FURIN	1.38e-04	198	129	7	5335_DN
Drug	Tolazamide [1156-19-0]; Down 200; 12.8uM; MCF7; HT_HG-U133A	SLC11A2 C15orf39 FBXO11 EVPL SHANK2 SIPA1L1 PRLR	1.38e-04	198	129	7	2842_DN
Drug	Folic acid [59-30-3]; Down 200; 9uM; PC3; HT_HG-U133A	NDST1 DNAH3 POR PLEKHA6 GPR107 VPS13A DNMBP	1.43e-04	199	129	7	5844_DN
Drug	Desipramine hydrochloride [58-28-6]; Down 200; 13.2uM; PC3; HT_HG-U133A	DENND5B SIPA1L3 PLEKHA6 MAP3K5 NF1 VCAN TNS1	1.43e-04	199	129	7	6693_DN
Drug	Delsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MYH9 RNGTT LMCD1 MAMLD1 EVPL ECPAS CRAT	1.43e-04	199	129	7	7212_DN
Drug	Niflumic acid [4394-00-7]; Down 200; 14.2uM; HL60; HT_HG-U133A	DNAH3 SLC11A2 INPP5D SIPA1L3 FURIN VCAN ALK	1.43e-04	199	129	7	2399_DN
Drug	Isometheptene mucate; Down 200; 8.2uM; MCF7; HT_HG-U133A	DOCK1 RNGTT BMP2K SIPA1L3 STK11 NF1 PEX19	1.43e-04	199	129	7	5502_DN
Drug	Perphenazine [58-39-9]; Down 200; 10uM; MCF7; HT_HG-U133A	SLC11A2 BMP2K ECPAS NF1 SIPA1L1 FURIN VPS13A	1.43e-04	199	129	7	5698_DN
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	DOCK1 NDST1 LMCD1 C15orf39 FBXO11 EVPL NF1	1.43e-04	199	129	7	7473_DN
Drug	Ciprofloxacin hydrochloride [93107-08-5]; Up 200; 10.8uM; PC3; HT_HG-U133A	RNGTT NIPSNAP3B LMCD1 STK4 VCAN PRKCA MVD	1.43e-04	199	129	7	6700_UP
Drug	eicosa-8,11,14-trienoic acid	ADAMTS3 AIRE SOCS5 PRKCA ALOXE3	1.45e-04	88	129	5	CID000003011
Drug	Pentylenetetrazole [54-95-5]; Down 200; 29uM; MCF7; HT_HG-U133A	RNGTT PLEKHA6 NF1 SIPA1L1 FURIN PEX19 PRLR	1.47e-04	200	129	7	5508_DN
Drug	Artemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A	C15orf39 ENTPD4 MAP3K5 OVGP1 NF1 SIPA1L1 VPS13A	1.47e-04	200	129	7	7007_UP
Drug	(-)-trans-Isopiperitenol	POR SOCS5	1.90e-04	4	129	2	CID000439410
Drug	AC1NRC6D	ENPP7 POR	1.90e-04	4	129	2	CID005288835
Drug	indole-3-carbinol	A2M DNAH3 ENPP7 RNGTT BMP2K NMRAL1 CRAT CHRNB1 MAP3K5 IDO2 CC2D2A MINDY4 SELENOI MTO1 PRLR TNS3 CDH17	2.22e-04	1130	129	17	ctd:C016517
Disease	Cutaneous Melanoma	STK11 NF1 ALK RAC1	3.11e-05	41	129	4	C0151779
Disease	succinylcarnitine measurement	ZNF536 CRAT LACTB	4.38e-05	16	129	3	EFO_0020020
Disease	coronary artery disease	ARHGAP42 ADAMTS3 BCAS3 INPP5D DOK3 PTPRO FURIN LRP1 MLN SELENOI TNS1 TNXB ALK TNS3 CDH17 RAC1	6.79e-05	1194	129	16	EFO_0001645
Disease	X-24544 measurement	UGT3A1 UGT3A2	1.13e-04	4	129	2	EFO_0800892
Disease	Sarcomatoid Renal Cell Carcinoma	ZNF536 RYR1 ALK HSPA9 YIPF3	2.54e-04	128	129	5	C1266043
Disease	Chromophobe Renal Cell Carcinoma	ZNF536 RYR1 ALK HSPA9 YIPF3	2.54e-04	128	129	5	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	ZNF536 RYR1 ALK HSPA9 YIPF3	2.54e-04	128	129	5	C1266044
Disease	Papillary Renal Cell Carcinoma	ZNF536 RYR1 ALK HSPA9 YIPF3	2.54e-04	128	129	5	C1306837
Disease	Renal Cell Carcinoma	ZNF536 RYR1 ALK HSPA9 YIPF3	2.54e-04	128	129	5	C0007134
Disease	Colorectal Carcinoma	DNAH3 SLC11A2 OBSCN CDKL5 STK11 OVGP1 NF1 CHD5 VPS13A LRP1 UGT3A2	2.68e-04	702	129	11	C0009402
Disease	intellectual disability (is_implicated_in)	GPI CDKL5 CC2D2A	3.04e-04	30	129	3	DOID:1059 (is_implicated_in)
Disease	Parkinson's disease (is_implicated_in)	A2M SLC11A2 FBXO7 HSPA9	3.51e-04	76	129	4	DOID:14330 (is_implicated_in)
Disease	Joubert syndrome (implicated_via_orthology)	ZIC1 CC2D2A	3.93e-04	7	129	2	DOID:0050777 (implicated_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ZNF536 RYR1 ALK HSPA9 YIPF3	4.96e-04	148	129	5	C0279702
Disease	orofacial cleft, sex interaction measurement	BCAS3 NF1 OSBPL5 TNS3	5.61e-04	86	129	4	EFO_0008343, MONDO_0000358
Disease	descending aortic diameter	LMCD1 ARHGEF40 LRP1 DISP2	6.12e-04	88	129	4	EFO_0021788
Disease	bilirubin measurement	BCAS3 INPP5D SIPA1L3 MGLL CACHD1 CRAT OSBPL5 DNMBP	7.49e-04	442	129	8	EFO_0004570
Disease	melanoma	MAP3K5 STK11 NF1 PTPRO ALK RAC1	7.98e-04	248	129	6	C0025202
Disease	Kunitz-type protease inhibitor 2 measurement	SIPA1L3 RYR1	8.34e-04	10	129	2	EFO_0008200
Disease	Asthma, Occupational	PRKCA CDH17	8.34e-04	10	129	2	C0264423
Disease	diabetic maculopathy	ZIC1 ALK	1.22e-03	12	129	2	EFO_0010133
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 LRP1	1.22e-03	12	129	2	DOID:3827 (implicated_via_orthology)
Disease	estradiol measurement	UGT3A1 FBXO11 SHANK2 UGT3A2	1.41e-03	110	129	4	EFO_0004697
Disease	membranous glomerulonephritis (biomarker_via_orthology)	A2M MAP3K5	1.67e-03	14	129	2	DOID:10976 (biomarker_via_orthology)
Disease	Testicular Germ Cell Tumor	DAZL STK11	1.67e-03	14	129	2	C1336708
Disease	alcohol use disorder (implicated_via_orthology)	KDM3A CHRNB1 RYR1 PRKCA RAC1	1.70e-03	195	129	5	DOID:1574 (implicated_via_orthology)
Disease	triacylglycerol 52:2 measurement	RIPK4 PTPRO MLN	1.81e-03	55	129	3	EFO_0010414
Disease	monocyte count	ARHGAP42 RNGTT ARID4B BMP2K BCAS3 INPP5D LILRA6 PLEKHA6 RYR1 MAP3K5 NF1 VCAN TNS3 TREML2	1.94e-03	1320	129	14	EFO_0005091
Disease	reticulocyte count	ARHGAP42 SLC43A2 MYH9 BMP2K BCAS3 INPP5D POR VPS13A ACAP2 TNS1 TNS3 TREML2	2.15e-03	1045	129	12	EFO_0007986
Disease	Congenital total cataract	SIPA1L3 DNMBP	2.19e-03	16	129	2	C0266539
Disease	Myasthenic Syndromes, Congenital, Slow Channel	SYT2 CHRNB1	2.19e-03	16	129	2	C0751885
Disease	congenital myasthenic syndrome (implicated_via_orthology)	SYT2 CHRNB1	2.19e-03	16	129	2	DOID:3635 (implicated_via_orthology)
Disease	reticulocyte measurement	ARHGAP42 SLC43A2 MYH9 BMP2K HSPA4L INPP5D ECPAS MAP3K5 VPS13A ACAP2 TNS1 TNS3	2.29e-03	1053	129	12	EFO_0010700
Disease	Congenital Myasthenic Syndromes, Postsynaptic	SYT2 CHRNB1	2.47e-03	17	129	2	C0751883
Disease	Congenital Myasthenic Syndromes, Presynaptic	SYT2 CHRNB1	3.09e-03	19	129	2	C0751884
Disease	DiGeorge syndrome (implicated_via_orthology)	DOCK1 NDST1	3.09e-03	19	129	2	DOID:11198 (implicated_via_orthology)
Disease	psychotic symptoms	ARID4B STK11 PRLR	4.22e-03	74	129	3	EFO_0005940

Protein segments in the cluster

Peptide	Gene	Start	Entry
MKALDEPPYLTVGTD	ARID4B	1	Q4LE39
LSPLSKGSMEAGPYL	ARHGEF40	1186	Q8TER5
KGSMEAGPYLPRALQ	ARHGEF40	1191	Q8TER5
YLPDLSPGDSLMKPA	RNPEP	491	Q9H4A4
MDDYSPSASGPLGKL	VCAN	436	P13611
APLGLPDKMEAQLGY	CHD5	1561	Q8TDI0
PNGVLRIYPGSLMDK	CACHD1	736	Q5VU97
VFYLPPDAGEKMGLS	CHRNB1	266	P11230
ETLPVEYLGGKPLCM	CRAT	156	P43155
KPLLGLPSYMLQSEE	DNMBP	1261	Q6XZF7
SELGPYMKDLGAQLD	ACAP2	211	Q15057
EYMVLELSEPLKPGS	LVRN	186	Q6Q4G3
GYQLDMQILPDGPKS	ANO4	26	Q32M45
FEYGMSIESPKLLPL	DHTKD1	646	Q96HY7
GNEPPLLIMIGYSDG	BCAS3	86	Q9H6U6
APEMINLYGGKPITT	BMP2K	231	Q9NSY1
PTPKGASLMDIYLDR	DISP2	441	A7MBM2
PELPGEYSMKVTGEG	A2M	1306	P01023
PGEPLAGMDTTLVYK	AIRE	381	O43918
DSMRKGLQDSYPGPS	C17orf113	496	A0A1B0GUU1
MLYSSRGDPEGQPLL	PCDHA9	1	Q9Y5H5
PITYPQGLAMAKEIG	RAC1	136	P63000
PKIMIAALDYDPGDG	RIMBP3B	1571	A6NNM3
PKIMIAALDYDPGDG	RIMBP3C	1571	A6NJZ7
SAGEIPLPKLYISMA	GPR107	256	Q5VW38
KTPALIVYGDQDPMG	ABHD14B	151	Q96IU4
PASKLILGMPTYGRS	CHIT1	256	Q13231
GKSYLLSLPTGDVPM	NMRAL1	171	Q9HBL8
GEMGRLKSYENQKPP	POR	261	P16435
EMDGLIFQPTGKYKP	RNGTT	436	O60942
SMQKDYPGLPVFLLG	MGLL	106	Q99685
DPLELVMTGAYSKPT	LILRB4	111	Q8NHJ6
DYGMKLPILRSNPED	MLEC	81	Q14165
PEGMDSDLIYPQGLS	MTO1	336	Q9Y2Z2
AITLPLGIVMDKYGP	SLC43A2	101	Q8N370
SGNRYLPGFPMKIDI	ALOXE3	186	Q9BYJ1
ELYNPKGIALDPAMG	LRP1	321	Q07954
PLGEYGLKPLSTVFM	ISG15	136	P05161
SNENLLPGYLKPETM	LACTB	426	P83111
PGSGNTYPKDMEALL	CCDC47	366	Q96A33
PQDLTPYSGKLMSAL	ECPAS	1391	Q5VYK3
PAGLMYEGVSQEPLK	IDO2	261	Q6ZQW0
ISILEPETGKDMSPY	EVPL	1686	Q92817
YELAVFQMKPGGPAL	NIPSNAP3B	146	Q9BS92
YRTEIAPGKGDMPTL	NDST1	111	P52848
AALAMEPTPGGVKYI	MVD	356	P53602
TMDPLETPIKDGILY	DOK3	56	Q7L591
GPYGLLQPFADAMKL	MT-ND1	41	P03886
PGFLMSIAYLDPGNI	SLC11A2	76	P49281
DLGPLMVTEALKPYS	GPI	161	P06744
DPLELVMTGFYNKPT	LILRA6	111	Q6PI73
YEILTPNSIPKGFMD	MYH9	721	P35579
TMEPVLGGTPYLDKF	NAGS	431	Q8N159
MGTPKLEKPNEGYLE	EXOSC7	66	Q15024
DINLPYLTMDSSGPK	HSPA9	326	P38646
APPGVTQKLGLQYME	LMCD1	121	Q9NZU5
MGEEGPPSLEYIQAK	MTMR4	1	Q9NYA4
SDMDYPLQGPGLLSV	NUP155	61	O75694
GGMQLLPDPLYSLPT	NUP155	196	O75694
SKGSKSPDLLMYQGP	MRPS36	56	P82909
TGIKDLMLYPLGPTA	PTPRO	531	Q16827
PDPAELLLMGSYLGK	POM121C	116	A8CG34
KAGMGPYSSPSEQVL	OBSCN	7631	Q5VST9
LEGPDPAELLLMGSY	POM121	126	Q96HA1
PAELLLMGSYLGKPG	POM121	131	Q96HA1
KELAGEMPPGLNFDL	PEX19	266	P40855
PKLPELPGINYSMDE	ADAMTS3	466	O15072
MPTQIIPGKALYDVG	KDM3A	721	Q9Y4C1
LMGNAIPEGPTAYVL	CC2D2A	1386	Q9P2K1
PLPLKGSVADYGNLM	DOCK1	1801	Q14185
TMQIGESLPKILYDP	DNAH3	4031	Q8TD57
YIESPITMIGAAPGK	FBXO11	301	Q86XK2
GYIPQGTEAKALSMP	FBXO7	211	Q9Y3I1
QPMKELYGINLSDGL	FIG4	796	Q92562
TMDRGLISYKGLPPE	FURIN	751	P09958
PGLLPRKGLYMANDL	GSTK1	56	Q9Y2Q3
PVPYLMGLQSKEGTD	DENND5B	341	Q6ZUT9
KLLQYGDMEEGASPP	ELMO3	571	Q96BJ8
NAALGPAMPYAPEKL	MAMLD1	396	Q13495
YPFSLRKPNSDULGM	SELENOI	376	Q9C0D9
TSQGYILPEGKIMPN	DAZL	26	Q92904
ELLDYGPNGMLLPKE	ENPP7	276	Q6UWV6
PKLPMDGLFLIQTYA	CDH17	386	Q12864
VLGPLPSEQMKLFYS	CDKL5	226	O76039
YSQGPGKMTSLPLDT	SEC24B	71	O95487
NVPEGGLVPKSLYMT	SEC14L5	481	O43304
ELSYGEVMGPLEKPG	SALL2	356	Q9Y467
GLQSCPMLVAKGYPD	RYR1	2306	P21817
LIYVAEGKGMTPLPS	CFAP47	2111	Q6ZTR5
KLSDMNDLPISSYPG	PPP4R1L	381	Q9P1A2
APSEKLIMGIPTYGR	OVGP1	251	Q12889
GDNELYPLSPGKDME	OSBPL5	36	Q9H0X9
GTLQYMAPEIIDKGP	MAP3K5	841	Q99683
LPALDMGGTSDPYVK	SYT2	166	Q8N9I0
MGGTSDPYVKVFLLP	SYT2	171	Q8N9I0
GILYPLMGFQLDVSP	TREML2	111	Q5T2D2
TTYDGIDGLPLPSML	SOCS5	496	O75159
KNLIPMDPNGLSDPY	PRKCA	181	P17252
PGKAPRYLMKLEGSG	IGLV4-60	61	A0A075B6I1
LEAMDGKEPIYTLPA	ARHGAP42	366	A6NI28
PKIMIAALDYDPGDG	RIMBP3	1571	Q9UFD9
LLGKQTGLTPDMPYL	ENTPD4	351	Q9Y227
VDPIKDMYSGLVGPL	HEPH	886	Q9BQS7
VPDPDTGLYMLQLAG	EPPK1	2941	P58107
VPDPDTGLYMLQLAG	EPPK1	4006	P58107
KPYPGAELSSMGAIV	SIPA1L1	846	O43166
LTKPEMFENPLYGSL	INPP5D	1011	Q92835
DLMDPELLGLTYIKG	SIPA1L2	1246	Q9P2F8
MSEEPPLDLTGKVYQ	SIPA1L3	1706	O60292
PSKEPAVLMGILGIY	SCYL2	536	Q6P3W7
ITTLDPGMAPYIKSG	PRRC1	241	Q96M27
PGMAPYIKSGGELDI	PRRC1	246	Q96M27
PLSDLLKGMLEYEPA	STK11	281	Q15831
KETMTPGYPQDLDII	TNS3	816	Q68CZ2
LMYIGPSEEGDKDTP	OR5K4	256	A6NMS3
LSMDGLFGTIAYLPP	RIPK4	176	P57078
EILPGLFLGPYSSAM	STYX	31	Q8WUJ0
PLYIDTKMRPSLDAG	SHANK2	1246	Q9UPX8
PLGILYTPALKVMEG	ALK	961	Q9UM73
YELIGSMPELKDNPF	CIB3	56	Q96Q77
GPVMYGKLPRLETDS	C15orf39	11	Q6ZRI6
ELEMFGSQPAYPEKL	PLEKHA6	571	Q9Y2H5
LLPNTVYIGGLMEKP	UGT3A1	261	Q6NUS8
DDLTMVLYSPGPKQA	VPS13A	1401	Q96RL7
DTDRMPLKLYLPGGN	MINDY4	321	Q4G0A6
PLKLYLPGGNSRMTQ	MINDY4	326	Q4G0A6
KYPATLEGLLSEMLP	MLN	96	P12872
RLPYELQKMPNGSAG	HSPA4L	86	O95757
MAGVKYPGQDPVDLD	TEX37	1	Q96LM6
QPAAEMAKGYLLLPG	TEX37	141	Q96LM6
GGKPSDPIIYQGIMD	TNXB	1036	P22105
ALSPLTNGLDKSYPM	TNS1	536	Q9HBL0
IFSLDSPMPLYILKG	PLAA	96	Q9Y263
QGMKPTYLDPDTDSG	PRLR	336	P16471
PSLPMENGPGKADLY	PIEZO2	431	Q9H5I5
LGKDYLPSSPGLLMV	nan	206	A8MX80
FDKMATLLAYLGPPE	NF1	1536	P21359
VYALLMPAGVPLTDG	USP9Y	1096	O00507
PQFLDPVLGYLMKGL	TNPO3	496	Q9Y5L0
LSEPSQLYGKGELPM	ZNF536	446	O15090
MLLDAGPQYPAIGVT	ZIC1	1	Q15915
PQKIAGELYGPLMLV	YIPF3	146	Q9GZM5
GITAIEMAEGKPPYA	STK4	211	Q13043
LLPNTVYVGGLMEKP	UGT3A2	261	Q3SY77
DMGYPLAVKLGTITP	USP13	251	Q92995