Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH4 MYH13 MYO5A MYH7B	6.13e-06	38	138	5	GO:0000146
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 MYH1 MYH4 MYH13 MYO5A MYH7B STARD9	1.80e-05	118	138	7	GO:0003774
GeneOntologyBiologicalProcess	organelle assembly	DNHD1 HIF1A MYOM1 CLASP1 SYNE1 CCNO CEP192 PATL1 TUBGCP4 ODF2 DICER1 HPS3 RHOA FSIP2 TTBK2 STARD9 SIPA1L1 HPS1 CEP295 FAM149B1 KNL1	1.41e-05	1138	134	21	GO:0070925
GeneOntologyBiologicalProcess	melanocyte differentiation	MYO5A ENPP1 ZEB2 HPS1	3.57e-05	29	134	4	GO:0030318
GeneOntologyBiologicalProcess	skeletal muscle satellite cell migration	RHOA RHOC	4.19e-05	2	134	2	GO:1902766
GeneOntologyCellularComponent	myosin filament	MYH1 MYH4 MYH13 MYOM1 MYH7B	5.18e-07	25	136	5	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH4 MYH13 MYH7B	3.11e-05	28	136	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH1 MYH4 MYH13 MYO5A MYH7B	4.09e-05	59	136	5	GO:0016459
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH4 MYH13	1.42e-04	16	136	3	GO:0005859
GeneOntologyCellularComponent	cell division site	TUBGCP4 STAMBP RHOA RHOB RHOC	1.76e-04	80	136	5	GO:0032153
GeneOntologyCellularComponent	cleavage furrow	STAMBP RHOA RHOB RHOC	6.71e-04	61	136	4	GO:0032154
GeneOntologyCellularComponent	lipid droplet	RAB40A LIPE RAB40AL RAB40C RAB40B	9.75e-04	116	136	5	GO:0005811
Domain	P-loop_NTPase	DNHD1 MYH1 MYH4 MYH13 MYO5A MYH7B GAL3ST4 AK9 RAB40A TEP1 DICER1 DDX11 RHOA RABL6 RHOB RHOC GUF1 STARD9 RAB40AL RAB40C RAB40B	9.67e-07	848	137	21	IPR027417
Domain	FAM47	FAM47A FAM47C FAM47B	1.54e-06	4	137	3	PF14642
Domain	FAM47	FAM47A FAM47C FAM47B	1.54e-06	4	137	3	IPR032743
Domain	Small_GTPase	RAB40A RHOA RABL6 RHOB RHOC GUF1 RAB40AL RAB40C RAB40B	2.79e-06	160	137	9	IPR001806
Domain	Myosin_N	MYH1 MYH4 MYH13 MYH7B	3.55e-06	15	137	4	PF02736
Domain	Myosin_N	MYH1 MYH4 MYH13 MYH7B	3.55e-06	15	137	4	IPR004009
Domain	Ras	RAB40A RHOA RABL6 RHOB RHOC RAB40AL RAB40C RAB40B	7.30e-06	136	137	8	PF00071
Domain	Myosin_tail_1	MYH1 MYH4 MYH13 MYH7B	7.83e-06	18	137	4	PF01576
Domain	Myosin_tail	MYH1 MYH4 MYH13 MYH7B	7.83e-06	18	137	4	IPR002928
Domain	Myosin_head_motor_dom	MYH1 MYH4 MYH13 MYO5A MYH7B	8.15e-06	38	137	5	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH4 MYH13 MYO5A MYH7B	8.15e-06	38	137	5	PS51456
Domain	Myosin_head	MYH1 MYH4 MYH13 MYO5A MYH7B	8.15e-06	38	137	5	PF00063
Domain	MYSc	MYH1 MYH4 MYH13 MYO5A MYH7B	8.15e-06	38	137	5	SM00242
Domain	Myosin-like_IQ_dom	MYH1 MYH4 MYH13 MYH7B	9.86e-06	19	137	4	IPR027401
Domain	-	MYH1 MYH4 MYH13 MYH7B	9.86e-06	19	137	4	4.10.270.10
Domain	SOCS	RAB40A RAB40AL RAB40C RAB40B	1.23e-05	20	137	4	SM00253
Domain	Small_GTP-bd_dom	RAB40A RHOA RHOB RHOC GUF1 RAB40AL RAB40C RAB40B	3.25e-05	167	137	8	IPR005225
Domain	SOCS_box	RAB40A RAB40AL RAB40C RAB40B	1.69e-04	38	137	4	PF07525
Domain	SOCS_box	RAB40A RAB40AL RAB40C RAB40B	1.87e-04	39	137	4	SM00969
Domain	SOCS_box	RAB40A RAB40AL RAB40C RAB40B	1.87e-04	39	137	4	IPR001496
Domain	SOCS	RAB40A RAB40AL RAB40C RAB40B	1.87e-04	39	137	4	PS50225
Domain	RAB	RAB40A RABL6 RAB40AL RAB40C RAB40B	1.99e-04	73	137	5	PS51419
Domain	IQ	MYH1 MYH4 MYH13 MYO5A MYH7B	3.23e-04	81	137	5	SM00015
Domain	RHO	RHOA RHOB RHOC	4.02e-04	20	137	3	PS51420
Domain	IQ_motif_EF-hand-BS	MYH1 MYH4 MYH13 MYO5A MYH7B	5.26e-04	90	137	5	IPR000048
Domain	IQ	MYH1 MYH4 MYH13 MYO5A MYH7B	6.12e-04	93	137	5	PS50096
Domain	SWIM	ZSWIM2 ZSWIM1	1.09e-03	7	137	2	PF04434
Domain	-	DNHD1 AK9 RAB40A TEP1 DICER1 DDX11 RHOA RABL6 RHOB RHOC GUF1 RAB40AL RAB40C RAB40B	1.18e-03	746	137	14	3.40.50.300
Domain	IQ	MYH1 MYH4 MYH13 MYO5A	1.84e-03	71	137	4	PF00612
Domain	BEACH	WDR81 NBEA	1.86e-03	9	137	2	PS50197
Domain	Beach	WDR81 NBEA	1.86e-03	9	137	2	PF02138
Domain	-	WDR81 NBEA	1.86e-03	9	137	2	1.10.1540.10
Domain	Beach	WDR81 NBEA	1.86e-03	9	137	2	SM01026
Domain	ZF_SWIM	ZSWIM2 ZSWIM1	1.86e-03	9	137	2	PS50966
Domain	BEACH_dom	WDR81 NBEA	1.86e-03	9	137	2	IPR000409
Domain	Znf_SWIM	ZSWIM2 ZSWIM1	1.86e-03	9	137	2	IPR007527
Domain	-	SRM METTL4 TRMT2B NSUN7 TRMT44	1.92e-03	120	137	5	3.40.50.150
Domain	SAM-dependent_MTases	SRM METTL4 TRMT2B NSUN7 TRMT44	2.06e-03	122	137	5	IPR029063
Domain	Znf_PHD-finger	PHRF1 CXXC1 KMT2C BRPF1	2.72e-03	79	137	4	IPR019787
Domain	Rap_GAP_dom	RALGAPB SIPA1L1	2.81e-03	11	137	2	IPR000331
Domain	RAPGAP	RALGAPB SIPA1L1	2.81e-03	11	137	2	PS50085
Domain	C8	FCGBP MUC5AC	3.36e-03	12	137	2	PF08742
Domain	TIL	FCGBP MUC5AC	3.36e-03	12	137	2	PF01826
Domain	Unchr_dom_Cys-rich	FCGBP MUC5AC	3.95e-03	13	137	2	IPR014853
Domain	C8	FCGBP MUC5AC	3.95e-03	13	137	2	SM00832
Domain	PHD	PHRF1 CXXC1 KMT2C BRPF1	4.18e-03	89	137	4	SM00249
Domain	Znf_PHD	PHRF1 CXXC1 KMT2C BRPF1	4.52e-03	91	137	4	IPR001965
Domain	Myotubularin-like_Pase_dom	MTMR4 SBF2	4.59e-03	14	137	2	IPR010569
Domain	TIL_dom	FCGBP MUC5AC	4.59e-03	14	137	2	IPR002919
Domain	uDENN	DENND4A SBF2	4.59e-03	14	137	2	SM00800
Domain	PPASE_MYOTUBULARIN	MTMR4 SBF2	4.59e-03	14	137	2	PS51339
Domain	Myotubularin_fam	MTMR4 SBF2	4.59e-03	14	137	2	IPR030564
Domain	Myotub-related	MTMR4 SBF2	4.59e-03	14	137	2	PF06602
Domain	Znf_FYVE_PHD	PHRF1 CXXC1 KMT2C MTMR4 BRPF1	4.59e-03	147	137	5	IPR011011
Domain	HEAT	CLASP1 SCYL3 RPTOR	5.25e-03	48	137	3	PF02985
Domain	uDENN	DENND4A SBF2	5.27e-03	15	137	2	PF03456
Domain	ZF_PHD_2	PHRF1 CXXC1 KMT2C BRPF1	5.27e-03	95	137	4	PS50016
Domain	ZF_PHD_1	PHRF1 CXXC1 KMT2C BRPF1	5.47e-03	96	137	4	PS01359
Domain	DENN	DENND4A SBF2	5.99e-03	16	137	2	SM00799
Domain	VWF_type-D	FCGBP MUC5AC	5.99e-03	16	137	2	IPR001846
Domain	DENN	DENND4A SBF2	5.99e-03	16	137	2	PF02141
Domain	VWFD	FCGBP MUC5AC	5.99e-03	16	137	2	PS51233
Domain	dDENN	DENND4A SBF2	5.99e-03	16	137	2	PF03455
Domain	UDENN	DENND4A SBF2	5.99e-03	16	137	2	PS50946
Domain	DDENN	DENND4A SBF2	5.99e-03	16	137	2	PS50947
Domain	VWD	FCGBP MUC5AC	5.99e-03	16	137	2	SM00216
Domain	dDENN	DENND4A SBF2	5.99e-03	16	137	2	SM00801
Domain	dDENN_dom	DENND4A SBF2	5.99e-03	16	137	2	IPR005112
Domain	uDENN_dom	DENND4A SBF2	5.99e-03	16	137	2	IPR005113
Domain	DENN	DENND4A SBF2	5.99e-03	16	137	2	PS50211
Domain	DENN_dom	DENND4A SBF2	5.99e-03	16	137	2	IPR001194
Domain	VWD	FCGBP MUC5AC	5.99e-03	16	137	2	PF00094
Domain	HEAT_type_2	CLASP1 SCYL3	6.76e-03	17	137	2	IPR021133
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_ROCKS	RHOA RHOB RHOC	3.23e-06	5	98	3	MM15221
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_CIT	RHOA RHOB RHOC	1.12e-05	7	98	3	MM15217
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_RHOTEKIN_AND_RHOPHILINS	RHOA RHOB RHOC	2.65e-05	9	98	3	M27551
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	RHOA RHOB RHOC	5.16e-05	11	98	3	MM15046
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	RHOA RHOB RHOC	1.40e-04	15	98	3	MM15037
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	PLEKHG2 PLEKHG5 RHOA RHOB RHOC	1.95e-04	77	98	5	MM15044
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	PLEKHG2 PLEKHG5 RHOA RHOB RHOC	2.33e-04	80	98	5	M800
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_ROCKS	RHOA RHOB RHOC	2.91e-04	19	98	3	M27493
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_CIT	RHOA RHOB RHOC	2.91e-04	19	98	3	M27489
Pathway	REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	RHOA RHOB RHOC	3.41e-04	20	98	3	M18415
Pathway	REACTOME_SEMAPHORIN_INTERACTIONS	DPYSL4 RHOA RHOB RHOC	4.27e-04	51	98	4	MM14967
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_PKNS	RHOA RHOB RHOC	5.22e-04	23	98	3	MM15216
Pathway	REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	RHOA RHOB RHOC	5.93e-04	24	98	3	M2243
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	EMC1 MYO5A VEZT SCYL3 RALGAPB PFAS NBEA CEP192 CUL7 ODF2 BCOR BIRC6 ZNF512B WWC2 MTMR4 SBF2 PNMA2 DMWD KNL1	5.39e-08	1049	141	19	27880917
Pubmed	RhoA, RhoB and RhoC have different roles in cancer cell migration.	RHOA RHOB RHOC	6.52e-08	3	141	3	23488932
Pubmed	A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.	RHOA RHOB RHOC	6.52e-08	3	141	3	12939257
Pubmed	Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.	RHOA RHOB RHOC	6.52e-08	3	141	3	29500478
Pubmed	RhoA, RhoB and RhoC differentially regulate endothelial barrier function.	RHOA RHOB RHOC	6.52e-08	3	141	3	28949796
Pubmed	Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells.	RHOA RHOB RHOC	6.52e-08	3	141	3	19477269
Pubmed	Divergence of Rho residue 43 impacts GEF activity.	RHOA RHOB RHOC	6.52e-08	3	141	3	22673745
Pubmed	The Role of RhoA, RhoB and RhoC GTPases in Cell Morphology, Proliferation and Migration in Human Cytomegalovirus (HCMV) Infected Glioblastoma Cells.	RHOA RHOB RHOC	6.52e-08	3	141	3	26741994
Pubmed	Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.	RHOA RHOB RHOC	6.52e-08	3	141	3	15642170
Pubmed	Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells.	RHOA RHOB RHOC	6.52e-08	3	141	3	27147504
Pubmed	Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.	RHOA RHOB RHOC	2.60e-07	4	141	3	10559899
Pubmed	XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.	RHOA RHOB RHOC	2.60e-07	4	141	3	12221096
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4 MYH13	2.60e-07	4	141	3	10388558
Pubmed	Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.	RHOA RHOB RHOC	2.60e-07	4	141	3	8662891
Pubmed	Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration.	RHOA RHOB RHOC	2.60e-07	4	141	3	22992742
Pubmed	Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.	RAB40A RAB40C RAB40B	2.60e-07	4	141	3	25661869
Pubmed	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.	RHOA RHOB RHOC	6.48e-07	5	141	3	8617235
Pubmed	Rho localization in cells and tissues.	RHOA RHOB RHOC	6.48e-07	5	141	3	15093731
Pubmed	A novel partner for the GTP-bound forms of rho and rac.	RHOA RHOB RHOC	6.48e-07	5	141	3	8543060
Pubmed	Rab40b and Tks5 interact at invadopodia during metastasis.	RAB40A RAB40AL RAB40B	6.48e-07	5	141	3	27909076
Pubmed	Small GTP-binding proteins and the regulation of the actin cytoskeleton.	RHOA RHOB RHOC	1.29e-06	6	141	3	7888179
Pubmed	Rho GTPases and the actin cytoskeleton.	RHOA RHOB RHOC	1.29e-06	6	141	3	9438836
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH4 MYH13	1.29e-06	6	141	3	10077619
Pubmed	The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases.	RHOA RHOB RHOC	1.29e-06	6	141	3	19286565
Pubmed	RHO binding to FAM65A regulates Golgi reorientation during cell migration.	RHOA RHOB RHOC	2.26e-06	7	141	3	27807006
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH4 MYH13	2.26e-06	7	141	3	35210422
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIF1A MCPH1 MYO5A EPB41L4B VEZT RALGAPB CEP192 PATL1 ZSWIM1 TEP1 F7 HPS3 KMT2C SLC19A1 RPTOR SBF2 KATNIP RAB40B SLC4A5 FGGY	2.60e-06	1489	141	20	28611215
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	PDE4C CYP2C18 CLASP1 RALGAPB PHRF1 PATL1 ODF2 BCOR WWC2 RPTOR SIPA1L1 BRPF1 YY1AP1 DMWD	3.48e-06	774	141	14	15302935
Pubmed	Evolution of the Rab family of small GTP-binding proteins.	RAB40A RAB40C RAB40B	3.60e-06	8	141	3	11697911
Pubmed	Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.	MYO5A RAB40A RAB40AL RAB40C RAB40B	3.93e-06	58	141	5	11856727
Pubmed	Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.	RHOA RHOB RHOC	5.38e-06	9	141	3	15151987
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 MYH13 MYO5A SYNE1 TEX15 BCOR BRPF1 SLC4A5	5.47e-06	234	141	8	36243803
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MYH1 MYH4 DENND4A TCERG1L MYH13 MYO5A MYH7B SYNE1 SMCHD1 CCNO FAM47B ODF2 CXXC1 ZEB2 DDX11 STARD9 CEP295 DMWD BAHCC1	6.23e-06	1442	141	19	35575683
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4 MYOM1	7.67e-06	10	141	3	19506036
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ERP44 EPB41L4B PHTF2 CEP192 PATL1 BCOR TTBK2 KMT2C WWC2 SIPA1L1 SBF2 HPS1 NADK ADAMTS18 CEP295 DMWD	8.95e-06	1084	141	16	11544199
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH4 MYOM1	1.05e-05	11	141	3	18310078
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	DENND4A CLASP1 RALGAPB CEP192 CUL7 BIRC6 SIPA1L1 PNMA2 NADK CEP295	1.51e-05	446	141	10	24255178
Pubmed	A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors.	RHOA RHOB	1.63e-05	2	141	2	33162807
Pubmed	RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.	RHOA RHOC	1.63e-05	2	141	2	21454503
Pubmed	Activation of a bacterial virulence protein by the GTPase RhoA.	RHOA RHOC	1.63e-05	2	141	2	19887681
Pubmed	Coding sequence of human rho cDNAs clone 6 and clone 9.	RHOB RHOC	1.63e-05	2	141	2	3283705
Pubmed	Functional analysis of the promoters of the small GTPases RhoA and RhoB in embryonic stem cells.	RHOA RHOB	1.63e-05	2	141	2	28739254
Pubmed	RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms.	PLEKHG5 RHOA	1.63e-05	2	141	2	27460990
Pubmed	Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1.	IL17A CXXC1	1.63e-05	2	141	2	31633019
Pubmed	Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.	RHOA RHOC	1.63e-05	2	141	2	12808121
Pubmed	Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis.	RHOB RHOC	1.63e-05	2	141	2	28960175
Pubmed	IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma.	HIF1A MUC5AC	1.63e-05	2	141	2	29031476
Pubmed	Refining the phenotype associated with CASC5 mutation.	MCPH1 KNL1	1.63e-05	2	141	2	26626498
Pubmed	IL-17A Orchestrates Reactive Oxygen Species/HIF1α-Mediated Metabolic Reprogramming in Psoriasis.	HIF1A IL17A	1.63e-05	2	141	2	38019129
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	1.63e-05	2	141	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	1.63e-05	2	141	2	11150240
Pubmed	Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7.	IL17A BMP7	1.63e-05	2	141	2	28812969
Pubmed	Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers.	RHOA RHOC	1.63e-05	2	141	2	20503409
Pubmed	Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.	RHOA RHOC	1.63e-05	2	141	2	7989340
Pubmed	Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.	RHOA RHOC	1.63e-05	2	141	2	33825439
Pubmed	Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.	HIF1A RHOA	1.63e-05	2	141	2	15598682
Pubmed	Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo.	RHOA RHOC	1.63e-05	2	141	2	20828398
Pubmed	Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.	RHOA RHOC	1.63e-05	2	141	2	15668138
Pubmed	Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma.	RHOA RHOC	1.63e-05	2	141	2	17896152
Pubmed	Co-expression of CD21L and IL17A defines a subset of rheumatoid synovia, characterised by large lymphoid aggregates and high inflammation.	IL17A CR2	1.63e-05	2	141	2	30114200
Pubmed	Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.	RHOA RHOC	1.63e-05	2	141	2	7835413
Pubmed	Mutation analysis of patients with Hermansky-Pudlak syndrome: a frameshift hot spot in the HPS gene and apparent locus heterogeneity.	HPS3 HPS1	1.63e-05	2	141	2	9497254
Pubmed	HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells.	HIF1A MXI1	1.63e-05	2	141	2	19254710
Pubmed	Hypoxia induces mucin expression and secretion in human bronchial epithelial cells.	HIF1A MUC5AC	1.63e-05	2	141	2	23084780
Pubmed	Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy.	RAB40A RAB40C	1.63e-05	2	141	2	34469730
Pubmed	A novel ras-related gene family.	RHOB RHOC	1.63e-05	2	141	2	3888408
Pubmed	Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB.	RHOA RHOB	1.63e-05	2	141	2	29059167
Pubmed	Chromosome localization of human ARH genes, a ras-related gene family.	RHOA RHOB	1.63e-05	2	141	2	2407642
Pubmed	Hypoxia-mediated mechanism of MUC5AC production in human nasal epithelia and its implication in rhinosinusitis.	HIF1A MUC5AC	1.63e-05	2	141	2	24840724
Pubmed	Activated HIF1α of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer.	HIF1A GDF15	1.63e-05	2	141	2	32388677
Pubmed	Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors.	GALNT3 ZEB2	1.63e-05	2	141	2	29516288
Pubmed	GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix.	RHOA RHOB	1.63e-05	2	141	2	24984542
Pubmed	ABCs of RhoGTPases indicating potential role as oncotargets.	RHOA RHOC	1.63e-05	2	141	2	28508825
Pubmed	Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways.	HIF1A MUC5AC	1.63e-05	2	141	2	21544845
Pubmed	Immunolocalization of RhoA and RhoB GTPases in pleomorphic adenoma of the parotid.	RHOA RHOB	1.63e-05	2	141	2	25454559
Pubmed	Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters.	RHOA RHOC	1.63e-05	2	141	2	19499974
Pubmed	HIF1α promotes tumor chemoresistance via recruiting GDF15-producing TAMs in colorectal cancer.	HIF1A GDF15	1.63e-05	2	141	2	33242463
Pubmed	IL-17-induced HIF1α drives resistance to anti-PD-L1 via fibroblast-mediated immune exclusion.	HIF1A IL17A	1.63e-05	2	141	2	35389431
Pubmed	Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α.	HIF1A RHOA	1.63e-05	2	141	2	21574962
Pubmed	Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.	HIF1A ROR1	1.63e-05	2	141	2	33506575
Pubmed	Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.	RHOA RHOC	1.63e-05	2	141	2	21208644
Pubmed	Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity.	RHOA RHOC	1.63e-05	2	141	2	19642867
Pubmed	Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.	CEP192 CEP295	1.63e-05	2	141	2	27562453
Pubmed	Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1α.	HIF1A GDF15	1.63e-05	2	141	2	28734801
Pubmed	A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain.	PAG1 HIF1A	1.63e-05	2	141	2	23671581
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	1.63e-05	2	141	2	11744674
Pubmed	HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.	HIF1A DICER1	1.63e-05	2	141	2	29251629
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	PLEKHG2 RHOA RHOB RHOC	1.72e-05	38	141	4	19911011
Pubmed	Kctd13 deletion reduces synaptic transmission via increased RhoA.	RHOA RHOB RHOC	1.81e-05	13	141	3	29088697
Pubmed	The SOCS box: a tale of destruction and degradation.	RAB40A RAB40AL RAB40C RAB40B	2.33e-05	41	141	4	12076535
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	RC3H2 DENND4A CLASP1 PFAS CEP192 DICER1 SIPA1L1	2.45e-05	209	141	7	36779422
Pubmed	Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations.	MYO5A HPS3 HPS1	2.86e-05	15	141	3	2379821
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH4 MYH7B	3.51e-05	16	141	3	19922871
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	ERP44 PHRF1 RNF25 CR2 RHOA RHOB SLC19A1 FHL1	3.86e-05	307	141	8	37499664
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DENND4A EMC1 VEZT SCYL3 WDR81 NBEA ATF6B HPS3 RPTOR FLCN	4.25e-05	504	141	10	34432599
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CLASP1 SYNE1 RALGAPB CEP192 ZEB2 STARD9 SIPA1L1 KATNIP YY1AP1	4.53e-05	407	141	9	12693553
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	PFAS BCOR SIPA1L1 SBF2 FLCN MXI1 KNL1	4.76e-05	232	141	7	25515538
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	4.88e-05	3	141	2	26059207
Pubmed	Disorders of vesicles of lysosomal lineage: the Hermansky-Pudlak syndromes.	HPS3 HPS1	4.88e-05	3	141	2	12125811
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	4.88e-05	3	141	2	36515178
Interaction	RAB9A interactions	DENND4A MYO5A VEZT SCYL3 RALGAPB NBEA CUL7 TRIM14 HPS3 RHOA RABL6 RHOB RHOC SLC19A1 RPTOR FLCN	2.00e-06	595	133	16	int:RAB9A
Interaction	RAB40AL interactions	RAB40A RAB40AL RAB40C RAB40B	3.10e-06	16	133	4	int:RAB40AL
Interaction	ERP44 interactions	ERP44 EPB41L4B SMCHD1 PFAS CUL7 BCOR KMT2C MTMR4 FHL1	5.74e-06	194	133	9	int:ERP44
Interaction	RTKN interactions	DENND4A RHOA RHOB RHOC RPTOR SIPA1L1 NADK	1.13e-05	115	133	7	int:RTKN
Interaction	F12 interactions	HIF1A WDR81 CUL7 TEP1 HPS3 RPTOR	1.19e-05	77	133	6	int:F12
Interaction	PHLDB2 interactions	PATL1 CUL7 RHOA RHOB RHOC SIPA1L1 NADK	4.62e-05	143	133	7	int:PHLDB2
Interaction	YWHAZ interactions	DENND4A ERP44 CLASP1 MYO5A RALGAPB PFAS CEP192 CUL7 BCOR PLEKHG5 FSIP2 WWC2 MTMR4 STARD9 RPTOR SIPA1L1 PNMA2 NADK KATNIP RAB40B FHL1 DMWD	5.08e-05	1319	133	22	int:YWHAZ
Interaction	TENM2 interactions	RHOA RHOB RHOC	5.92e-05	12	133	3	int:TENM2
Cytoband	Xp21.1	FAM47A FAM47C FAM47B	1.58e-04	34	141	3	Xp21.1
GeneFamily	Myosin heavy chains	MYH1 MYH4 MYH13 MYH7B	8.57e-07	15	93	4	1098
GeneFamily	Rho family GTPases	RHOA RHOB RHOC	1.41e-04	20	93	3	390
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A SBF2 FLCN	2.79e-04	25	93	3	504
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM2 ZSWIM1	9.20e-04	9	93	2	90
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 NBEA	9.20e-04	9	93	2	1230
GeneFamily	PHD finger proteins	PHRF1 CXXC1 KMT2C BRPF1	1.20e-03	90	93	4	88
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR4 SBF2	2.63e-03	15	93	2	903
Coexpression	CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3	PAG1 CYP2C18 GALNT3 EPB41L4B GDF15 SCYL3 PHTF2 RBKS NSUN7 HPS3 FCGBP FZD5 SBF2 RAB40B MUC5AC	8.34e-06	726	140	15	M4210
Coexpression	MCCABE_HOXC6_TARGETS_UP	CHRNA2 BMP7 SIPA1L1	1.74e-05	10	140	3	M16591
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP	ENPP1 GAL3ST4 RAB40A SVEP1 RAB40AL RAB40B	1.95e-05	103	140	6	MM483
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 NBEA PLEKHG2 ZEB2	7.30e-07	159	140	7	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 NBEA PLEKHG2 ZEB2	1.14e-06	170	140	7	876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 NBEA PLEKHG2 ZEB2	1.14e-06	170	140	7	1f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	MYOM1 CEP192 ZNF512B STARD9 TIGD5 LSM14B MXI1	1.61e-06	179	140	7	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	droplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNO CEP192 ZEB2 DDX11 CEP295 KNL1	1.39e-05	165	140	6	96f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCNO FSIP2 FCGBP CEP295 MUC5AC BAHCC1	1.44e-05	166	140	6	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCNO FSIP2 FCGBP CEP295 MUC5AC BAHCC1	1.44e-05	166	140	6	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCNO FSIP2 FCGBP CEP295 MUC5AC BAHCC1	1.44e-05	166	140	6	4586d6725403f879fc96f67be579022587ce1906
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PHRF1 PLEKHG2 CUL7 FCN3 KMT2C FAM149B1	2.07e-05	177	140	6	eb0cfe8e9a91910f9979608ed47add48d98ce4dd
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	PAG1 CLASP1 SMCHD1 TUBGCP4 BIRC6 ZEB2	2.73e-05	186	140	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 ZEB2 STARD9	2.81e-05	187	140	6	15d6e158562d7d85af3ceaf955439b379c8fce81
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 ZEB2 STARD9	2.81e-05	187	140	6	f62074b631fd45ad299c69d71b09267b04d656ee
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HIF1A MYO5A PLEKHG2 ZEB2 CD14 SIPA1L1	2.90e-05	188	140	6	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	PAG1 DENND4A SMCHD1 BIRC6 ZEB2 KMT2C	2.90e-05	188	140	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYOM1 SYNE1 ROR1 PHTF2 ZEB2 STARD9	2.90e-05	188	140	6	32f22a4d8cb98fd8b8fa0fbf28ef9266d711d081
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GDF15 CCNO ZSWIM2 NBEA FCGBP MUC5AC	3.08e-05	190	140	6	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND4A BIRC6 ZEB2 KMT2C SIPA1L1 SBF2	3.36e-05	193	140	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	MYO5A TRIM14 ZEB2 CD14 SIPA1L1 KNL1	3.36e-05	193	140	6	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ROR1 ZEB2 SVEP1 COL24A1 SBF2 FHL1	3.66e-05	196	140	6	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	nucseq-Immune-Immune_Myeloid-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HIF1A MYO5A GAL3ST4 ZEB2 CD14 SIPA1L1	3.76e-05	197	140	6	6f41c8f815851968849428ec92c16745bd01a3fb
ToppCell	nucseq-Immune-Immune_Myeloid-IM-IM\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HIF1A MYO5A GAL3ST4 ZEB2 CD14 SIPA1L1	3.76e-05	197	140	6	304044ace926943b8eb588f686ecbe5d1689a809
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE4C CYP2C18 GDF15 CCNO NBEA MUC5AC	3.98e-05	199	140	6	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE4C CYP2C18 GDF15 CCNO NBEA MUC5AC	3.98e-05	199	140	6	e03bdc7cb825e287f41b834ec6061d23c1c03b04
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	TMPRSS9 SYNE1 TEX15 ZEB2 SVEP1 FHL1	4.10e-05	200	140	6	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ENPP1 SYNE1 ZEB2 SVEP1 STARD9 FHL1	4.10e-05	200	140	6	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	TMPRSS9 SYNE1 TEX15 ZEB2 SVEP1 FHL1	4.10e-05	200	140	6	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	TMPRSS9 SYNE1 TEX15 ZEB2 SVEP1 FHL1	4.10e-05	200	140	6	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH13 CHRNA2	4.35e-05	62	140	4	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH13 CHRNA2	4.35e-05	62	140	4	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chrna2_Ptgdr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYH1 MYH4 TCERG1L MYH13 CHRNA2	4.72e-05	125	140	5	d05556ea185c15815a4f8643f1c01185badbeece
Drug	Labetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A	EMC1 PHTF2 DPYSL4 RBKS CUL7 TEP1 SIPA1L1 HPS1 THNSL2	2.69e-06	192	138	9	6809_DN
Drug	SureCN4141578	HIF1A RHOA RHOB	1.19e-05	8	138	3	CID011594966
Drug	formycin triphosphate	MYH1 MYH4 MYH13 MYO5A MYH7B	1.43e-05	51	138	5	CID000122274
Drug	Adenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; HL60; HG-U133A	EMC1 PFAS RBKS TRIM14 ZEB2 ZNF512B SLC19A1 HPS1	1.98e-05	188	138	8	1622_DN
Drug	Nifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A	DENND4A EMC1 CCNO PHTF2 DPYSL4 SLC19A1 HPS1 FHL1	2.22e-05	191	138	8	2850_DN
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A	GDF15 RBKS TEX15 SVEP1 FLCN KATNIP FAM149B1 LSM14B	2.22e-05	191	138	8	7417_UP
Drug	Ricinine [524-40-3]; Down 200; 24.4uM; HL60; HT_HG-U133A	RALGAPB RNF25 RBKS SIPA1L1 HPS1 NADK FAM149B1 LSM14B	2.39e-05	193	138	8	2505_DN
Drug	GW8510; Up 200; 10uM; MCF7; HT_HG-U133A	PDE4C GDF15 ENPP1 CUL7 TRIM14 BMP7 HPS1 NADK	2.39e-05	193	138	8	7080_UP
Drug	imazaquin	MYO5A MYH7B RPTOR	2.53e-05	10	138	3	CID000054739
Drug	Benzylpenicillin sodium [69-57-8]; Down 200; 11.2uM; HL60; HT_HG-U133A	HIF1A PHTF2 TEP1 TRMT2B GUF1 SLC19A1 ZNF197 FLCN	2.67e-05	196	138	8	6155_DN
Drug	Vincamine [1617-90-9]; Down 200; 11.2uM; HL60; HT_HG-U133A	RC3H2 RBKS DICER1 ZNF512B ZNF197 HPS1 FHL1 DKK2	2.67e-05	196	138	8	2367_DN
Drug	purealin	MYH1 MYH4 MYH13 MYO5A MYH7B	2.69e-05	58	138	5	CID006419303
Drug	Nomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A	ERP44 VEZT PHTF2 SVEP1 SLC19A1 RAB40C LSM14B FHL1	2.77e-05	197	138	8	7217_UP
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A	RC3H2 CLASP1 SMCHD1 PHTF2 RHOC GUF1 BMP7 FAM149B1	2.77e-05	197	138	8	5350_DN
Drug	Prednisolone [50-24-8]; Down 200; 11uM; MCF7; HT_HG-U133A	ERP44 RALGAPB TRIM14 BMP7 SLC19A1 FAM149B1 LSM14B FHL1	2.87e-05	198	138	8	5526_DN
Drug	4-chloroaniline	MYH1 MYH4 HIF1A MYH13 MYH7B GDF15 RHOA PNMA2	3.31e-05	202	138	8	CID000007812
Drug	2-methyl-5-(1-methylethenyl)cyclohexanol	RHOA RHOB	3.65e-05	2	138	2	ctd:C534305
Drug	perillic acid	RHOA RHOB	3.65e-05	2	138	2	ctd:C078706
Drug	cytotoxic necrotizing factor type 1	RHOA RHOB	3.65e-05	2	138	2	ctd:C060296
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0111269 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0111602 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0111596 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0110454 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0080719 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	8.61e-08	10	135	4	DOID:0080326 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	2.02e-07	12	135	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	2.02e-07	12	135	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	2.90e-07	13	135	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	5.50e-07	15	135	4	DOID:0050646 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B FHL1	2.72e-06	48	135	5	DOID:423 (implicated_via_orthology)
Disease	ulcerative colitis (implicated_via_orthology)	RHOA RHOB RHOC	3.23e-06	7	135	3	DOID:8577 (implicated_via_orthology)
Disease	peroxisomal biogenesis disorder (implicated_via_orthology)	RHOA RHOB RHOC	5.16e-06	8	135	3	DOID:0080377 (implicated_via_orthology)
Disease	syndromic microphthalmia 2 (implicated_via_orthology)	BCORP1 BCOR	2.08e-05	2	135	2	DOID:0111809 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B DICER1	3.40e-05	80	135	5	DOID:12930 (implicated_via_orthology)
Disease	S-1-pyrroline-5-carboxylate measurement	TIGD5 PYCR3	1.24e-04	4	135	2	EFO_0800136
Disease	ovarian carcinoma (is_marker_for)	RHOA RHOC BMP7	2.82e-04	28	135	3	DOID:4001 (is_marker_for)
Disease	Emery-Dreifuss muscular dystrophy	SYNE1 FHL1	3.08e-04	6	135	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE1 FHL1	3.08e-04	6	135	2	C0410189
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13 MYH7B	3.21e-04	71	135	4	DOID:0050700 (implicated_via_orthology)
Disease	microcephaly (implicated_via_orthology)	MCPH1 WDR81 ODF2	4.22e-04	32	135	3	DOID:10907 (implicated_via_orthology)
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE1 FHL1	4.30e-04	7	135	2	C0751337
Disease	Hermanski-Pudlak Syndrome	HPS3 HPS1	9.13e-04	10	135	2	C0079504
Disease	proteinuria (biomarker_via_orthology)	HIF1A ZEB2	9.13e-04	10	135	2	DOID:576 (biomarker_via_orthology)
Disease	Hermansky-Pudlak syndrome	HPS3 HPS1	9.13e-04	10	135	2	cv:C0079504
Disease	breast cancer (is_marker_for)	F7 RHOA RHOB RHOC BMP7	1.65e-03	185	135	5	DOID:1612 (is_marker_for)
Disease	hypertension (is_marker_for)	HIF1A IL17A F7	1.86e-03	53	135	3	DOID:10763 (is_marker_for)
Disease	platelet storage pool deficiency (implicated_via_orthology)	HPS3 HPS1	2.10e-03	15	135	2	DOID:2223 (implicated_via_orthology)
Disease	Autosomal recessive primary microcephaly	MCPH1 KNL1	2.10e-03	15	135	2	cv:C3711387
Disease	osteoarthritis (implicated_via_orthology)	ENPP1 BMP7	2.10e-03	15	135	2	DOID:8398 (implicated_via_orthology)
Disease	Prostatic Neoplasms	HIF1A CYP2C18 GALNT3 ERP44 GDF15 KMT2C BMP7 BRPF1 MXI1	2.17e-03	616	135	9	C0033578
Disease	Malignant neoplasm of prostate	HIF1A CYP2C18 GALNT3 ERP44 GDF15 KMT2C BMP7 BRPF1 MXI1	2.17e-03	616	135	9	C0376358
Disease	colorectal cancer (is_implicated_in)	BCOR F7 DICER1 FLCN	2.35e-03	121	135	4	DOID:9256 (is_implicated_in)
Disease	primary autosomal recessive microcephaly (is_implicated_in)	MCPH1 KNL1	2.39e-03	16	135	2	DOID:0070296 (is_implicated_in)
Disease	asthma (biomarker_via_orthology)	IL17A RHOA MUC5AC	2.53e-03	59	135	3	DOID:2841 (biomarker_via_orthology)
Disease	cystic fibrosis (is_marker_for)	IL17A CD14 MUC5AC	2.91e-03	62	135	3	DOID:1485 (is_marker_for)
Disease	cerebral infarction (is_marker_for)	HIF1A F7	3.38e-03	19	135	2	DOID:3526 (is_marker_for)
Disease	Hemorrhage	F7 HPS1	3.74e-03	20	135	2	C0019080
Disease	cortisol measurement	TMPRSS9 BMP7	3.74e-03	20	135	2	EFO_0005843
Disease	stomach cancer (is_implicated_in)	BCOR TEP1 KMT2C	4.44e-03	72	135	3	DOID:10534 (is_implicated_in)
Disease	Autosomal Recessive Primary Microcephaly	MCPH1 KNL1	4.52e-03	22	135	2	C3711387
Disease	Primary microcephaly	MCPH1 KNL1	4.52e-03	22	135	2	C0431350

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLKPVLSDLPPHCTR	nan	81	A8MWP4
TCLTHPVPTLLAQPE	BAHCC1	2391	Q9P281
SLILHDLIPPPVCRF	BIRC6	1841	Q9NR09
TSLLIACKQVEVHPP	CCNO	181	P22674
QKPTHSSCIPLLRLP	BCORP1	46	Q8N888
PVELCHPLRLKLSPS	CHRNA2	386	Q15822
EHLCPALPLVTPKTF	DNHD1	3101	Q96M86
CFGILTAKPIPQIPH	DICER1	801	Q9UPY3
QILVPELCAIHPIPA	DICER1	1031	Q9UPY3
ICIPVTESILTPHIP	DKK2	126	Q9UBU2
TLVHFINPETVPKPC	BMP7	381	P18075
SASPAIPPLVHCADK	BCOR	271	Q6W2J9
FQKPSCPLVLPVKHS	C2orf73	106	Q8N5S3
TALCPRIHEVPLLEP	DMWD	581	Q09019
PSSSCLLHQKPPVLR	ADAMTS18	1156	Q8TE60
ICIIIPSKGESPPHT	DENND4A	161	Q7Z401
TVPLPREPCGHLKTS	RC3H2	756	Q9HBD1
VSCTPVHLVDKLPLP	RAB40A	201	Q8WXH6
VSCTPVHLVDKLPLP	RAB40B	201	Q12829
VSCTPVHLIDKLPLP	RAB40C	201	Q96S21
VSCTPVHLVDKLPLP	RAB40AL	201	P0C0E4
ELPKVPTHVPVCVLG	RABL6	161	Q3YEC7
TLCLHKQPVEPLPGF	GUF1	336	Q8N442
CVVLSQTEPEPKHIP	RBKS	241	Q9H477
SEPPKIGVSHLCLEP	FAM47C	416	Q5HY64
SHLCPEPPKTRVSHL	FAM47C	496	Q5HY64
VSHLCPEPPKTRVSS	FAM47C	651	Q5HY64
LKTQEHPSCPGPREL	FCN3	21	O75636
VPSFTQQILCPKPVH	PATL1	201	Q86TB9
SIHIVIPKGTFKPPC	KMT2C	4361	Q8NEZ4
QKPSVCHRPCKIEPV	HDX	211	Q7Z353
PASSPPVAKLCELVH	MCPH1	766	Q8NEM0
SLPKDLLHTTPCFIP	NEUROG1	221	Q92886
PRTLFCTEVLHAPLP	FLCN	16	Q8NFG4
KIPECIHLSSLPEPL	SBF2	301	Q86WG5
VLICEPIPHPSNIEI	HIF1A	221	Q16665
VKCPPVHEEPSLIQQ	KATNIP	721	O60303
DITVCEPPKAQHTLP	LSM14B	76	Q9BX40
EVLCHPRTPLDPVST	FSIP2	4266	Q5CZC0
PHFVRCIVPNENKTP	MYH7B	716	A7E2Y1
TPICPHSLSFRPIVV	NADK	346	O95544
LVHCADLSNPTKPLP	PDE4C	541	Q08493
LTHLLVHVEPCEAPP	CUL7	1096	Q14999
VSHLCPEPPKTLVSS	FAM47B	256	Q8NA70
RPVHSSCIPSVLKPV	PHRF1	401	Q9P1Y6
ICIPPSVHVQPLELT	LRRC24	256	Q50LG9
PVITSNVPCFHSIKP	KNL1	1571	Q8NG31
PPVRSALEKILAVCH	TUBGCP4	166	Q9UGJ1
IRSPLLCDVIKPAPH	GARIN5A	21	Q6IPT2
KEVHPLVQCPFTRNP	ENPP1	606	P22413
LHRLKPDTVPAPCCV	GDF15	261	Q99988
PHFVRCIIPNETKTP	MYH1	671	P12882
LSKVFEPCHTVIPPL	MUC5AC	5151	P98088
PATVPCISPELLAHL	PNMA2	131	Q9UL42
HSPEKVTLTKPCAPV	ODF3	221	Q96PU9
CPSPHLLPEINKIIS	OR11L1	261	Q8NGX0
HVIPPDNILPLVICS	DDX11	651	Q96FC9
PPHCPNSFRLEKILV	IL17A	126	Q16552
PSCPPRQRLVFLKTH	GAL3ST4	61	Q96RP7
HPKQVSSTKPVPLNC	MTMR4	986	Q9NYA4
NTIPHIFCDVTPLLK	OR1F2P	171	Q96R84
LHSTLLNPIPKCRPA	SCYL3	221	Q8IZE3
RVSHPVSKARKPPVC	FHL1	236	Q13642
KCREPFVPILKESHP	FZD5	191	Q13467
SCPGKISVPPVRNLH	DPYSL4	521	O14531
LLPLVHVSATTPEPC	CD14	11	P08571
QVLCPEHSRDPKVPA	CXXC1	546	Q9P0U4
IPLCKVIHCHPPPVI	CR2	711	P20023
PLSSCHKLVDPQGPL	FCGBP	2671	Q9Y6R7
TCSLVVLDKQFHPLP	FGGY	86	Q96C11
CPPLPTTSVIIVFHN	GALNT3	181	Q14435
SVCPSLVVRPKPLHS	BARX2	46	Q9UMQ3
LVVRPKPLHSCTGSP	BARX2	51	Q9UMQ3
HPLLHIQKTPADCPV	ERP44	306	Q9BS26
TVLPEHLILVAPSPC	CEP192	2131	Q8TEP8
EFCLKPPETPVSHLL	FAM47A	186	Q5JRC9
LLPTNLPHAVTCDVK	CYP2C18	361	P33260
FPHPPQCTLLVKDKE	EMC1	581	Q8N766
IPCPPALCSVRKIHL	ESRG	51	Q1W209
AEDTLQTLVPHCPVP	HPS1	331	Q92902
DSTIPLSHPKIPRCQ	CEP295	1226	Q9C0D2
QTPLLPSPVADHVKC	EPB41L4B	596	Q9H329
LPIPDHKLIVSVPCT	METTL4	401	Q8N3J2
KSLPPVHIVACALDP	LIPE	981	Q05469
PEVKHFCPNVPIILV	RHOC	101	P08134
PHCLEITPPSSEKLV	ODF2	86	Q5BJF6
CVLSELHPLVLPRVP	FAM149B1	316	Q96BN6
SHPIIPHFLCDILPV	OR10P1	171	Q8NGE3
VAHEEPLKAPPLRIC	AK9	981	Q5TCS8
SIFEKCHPIPAPLAQ	AK9	1321	Q5TCS8
PEVKHFCPNVPIILV	RHOA	101	P61586
PEVKHFCPNVPIILV	RHOB	101	P62745
TVHCQIVSTRTPKPP	PHTF2	181	Q8N3S3
PKSERLSCLLHPIIP	TRMT2B	131	Q96GJ1
LSCLLHPIIPSPVIN	TRMT2B	136	Q96GJ1
PVDLFPHTPHCELVL	TRMT2B	486	Q96GJ1
VVLRTVIPKTSPHCP	TRMT44	181	Q8IYL2
LRHSPKVETTDCPVP	SMCHD1	1971	A6NHR9
QLLKECHPPVTETLT	SYNE1	7196	Q8NF91
VAEPKQVPHILCSPS	HPS3	636	Q969F9
PVVLTDHVVPLCLPE	F7	311	P08709
APKALVPTCLPTHSL	NSUN7	681	Q8NE18
VCTQVVHKPHPEPDS	NBEA	821	Q8NFP9
KVVIIPPHDDCTPRR	SIPA1L1	1021	O43166
TEPTCHLPAVSKVLP	SIPA1L1	1236	O43166
QCTPSLDTHPLPLVE	THNSL2	241	Q86YJ6
EPLLPLKCPATQPHV	SPATA31E1	226	Q6ZUB1
PHFVRCIIPNETKTP	MYH4	671	Q9Y623
PPCVTLGKSLHLSEP	OCSTAMP	516	Q9BR26
FVPEKVASPEHCPLS	STARD9	4031	Q9P2P6
CSPKKCPLPENITHI	SVEP1	3176	Q4LDE5
KCHQSRELPRIPPES	PAG1	126	Q9NWQ8
TKPHVLPAVLAEVAP	PYCR3	76	Q53H96
PSVVKFHPFTPCIAV	RPTOR	1026	Q8N122
VSVPCIPPHRLSKIT	BRPF1	511	P55201
VLHVKTESLAPPLCL	ATF6B	121	Q99941
SSIHPEQCIKVLCPI	CLASP1	1416	Q7Z460
CTTLIPTKIPEHSPP	COL24A1	256	Q17RW2
ELHCKVSGNPPPTIR	ROR1	76	Q01973
TVELVPVFPHLCPSA	TCERG1L	131	Q5VWI1
RTPVQLLSCPPHLLK	PLEKHG5	861	O94827
IAAEICPHPPTDLVA	ZNF197	161	O14709
GRQSPLCPKFEVHTP	ZNF2	116	Q9BSG1
CLFRTKVHPPTESIL	WWC2	751	Q6AWC2
RTPKTPVLIHSFPAC	TEP1	2091	Q99973
IQPSDCHTTVRPAKP	STAMBP	216	O95630
CPDITATVTPDLKHP	PFAS	831	O15067
PPLPVATQHICEKIP	RNF25	306	Q96BH1
ETCPQLAVHPPGVSK	SLC19A1	561	P41440
LPALLHKPCVPAVSR	TTBK2	486	Q6IQ55
PVHTTSKRPCVDPEL	FAM90A2P	151	Q658T7
VCLPAATHIFPPSKK	TMPRSS9	311	Q7Z410
PHFVRCLIPNETKTP	MYH13	671	Q9UKX3
CFGLETPKLHVPSVI	SLC4A5	796	Q9BY07
LPLCSHPNPRKVLII	SRM	86	P19623
CHPVLASVILNSPPL	RALGAPB	556	Q86X10
ELCHPVPLSFEPVKS	TRIM14	196	Q14142
RCIKPAPVIHPASVI	YY1AP1	586	Q9H869
QTLLPPIVHKNIVCP	ZSWIM2	511	Q8NEG5
PIAISRHTPPCKMVL	ZNF512B	311	Q96KM6
CADIHVPTTPALPKE	PLEKHG2	1011	Q9H7P9
PRHLLKQFTVCDVPL	TEX29	11	Q8N6K0
PILPAHSETCKVPTL	TEX15	1576	Q9BXT5
NPHCTVVPLKQPTLH	VEZT	516	Q9HBM0
RVCTILVDPHFLPLP	ZSWIM1	141	Q9BR11
VTNCDPPLRLTKPSH	ZEB2	751	O60315
QKAVLLVAHPPCPSP	TIGD5	351	Q53EQ6
LCTRHPKEVPVSLQP	WDR81	806	Q562E7
TVPDCKLLLHVPPRN	KLHL38	266	Q2WGJ6
KVLIPLGPDCTRHTT	MXI1	91	P50539
DSCTIPPKHEPLCIF	MYO5A	346	Q9Y4I1
IAVPGPPHSLKCSEV	MYOM1	1036	P52179