Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	extracellular matrix	ADAMTS19 SPON1 ANGPT4 PCSK6 CELA2A REG3G LOXL4 ADAMTS13 CELA2B	3.07e-05	656	52	9	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	ADAMTS19 SPON1 ANGPT4 PCSK6 CELA2A REG3G LOXL4 ADAMTS13 CELA2B	3.15e-05	658	52	9	GO:0030312
GeneOntologyCellularComponent	keratohyalin granule	CELA2A CELA2B	6.04e-05	5	52	2	GO:0036457
GeneOntologyCellularComponent	collagen-containing extracellular matrix	SPON1 ANGPT4 PCSK6 CELA2A REG3G LOXL4 CELA2B	3.22e-04	530	52	7	GO:0062023
Domain	SPRY	TRIM49 RNF135 TRIM49C TRIM49B RYR1	3.87e-06	87	51	5	SM00449
Domain	SPRY	TRIM49 RNF135 TRIM49C TRIM49B RYR1	5.67e-06	94	51	5	PF00622
Domain	SPRY_dom	TRIM49 RNF135 TRIM49C TRIM49B RYR1	5.67e-06	94	51	5	IPR003877
Domain	B30.2/SPRY	TRIM49 RNF135 TRIM49C TRIM49B RYR1	5.98e-06	95	51	5	IPR001870
Domain	B302_SPRY	TRIM49 RNF135 TRIM49C TRIM49B RYR1	5.98e-06	95	51	5	PS50188
Domain	Wnt10	WNT10B WNT10A	7.31e-06	2	51	2	IPR013302
Domain	SRCR	CD6 LOXL4 CD163	2.46e-05	21	51	3	PF00530
Domain	TSP_1	ADAMTS19 SPON1 ADGRB3 ADAMTS13	2.61e-05	63	51	4	PF00090
Domain	ConA-like_dom	TRIM49 MALRD1 RNF135 TRIM49C TRIM49B RYR1	2.81e-05	219	51	6	IPR013320
Domain	TSP1	ADAMTS19 SPON1 ADGRB3 ADAMTS13	2.95e-05	65	51	4	SM00209
Domain	TSP1_rpt	ADAMTS19 SPON1 ADGRB3 ADAMTS13	2.95e-05	65	51	4	IPR000884
Domain	TSP1	ADAMTS19 SPON1 ADGRB3 ADAMTS13	2.95e-05	65	51	4	PS50092
Domain	Butyrophylin	TRIM49 RNF135 TRIM49C TRIM49B	3.96e-05	70	51	4	IPR003879
Domain	SR	CD6 LOXL4 CD163	4.23e-05	25	51	3	SM00202
Domain	-	CD6 LOXL4 CD163	4.23e-05	25	51	3	3.10.250.10
Domain	SRCR_1	CD6 LOXL4 CD163	4.77e-05	26	51	3	PS00420
Domain	SRCR_2	CD6 LOXL4 CD163	4.77e-05	26	51	3	PS50287
Domain	SRCR-like_dom	CD6 LOXL4 CD163	4.77e-05	26	51	3	IPR017448
Domain	SRCR	CD6 LOXL4 CD163	5.36e-05	27	51	3	IPR001190
Domain	HRM	ADGRB3 CALCRL ADGRA2	5.99e-05	28	51	3	PF02793
Domain	GPCR_2_secretin-like_CS	ADGRB3 CALCRL ADGRA2	1.08e-04	34	51	3	IPR017983
Domain	G_PROTEIN_RECEP_F2_1	ADGRB3 CALCRL ADGRA2	1.76e-04	40	51	3	PS00649
Domain	GPCR_2_extracellular_dom	ADGRB3 CALCRL ADGRA2	1.76e-04	40	51	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	ADGRB3 CALCRL ADGRA2	1.76e-04	40	51	3	PS50227
Domain	G_PROTEIN_RECEP_F2_2	ADGRB3 CALCRL ADGRA2	3.43e-04	50	51	3	PS00650
Domain	7tm_2	ADGRB3 CALCRL ADGRA2	3.43e-04	50	51	3	PF00002
Domain	GPCR_2_secretin-like	ADGRB3 CALCRL ADGRA2	5.88e-04	60	51	3	IPR000832
Domain	GPCR_2-like	ADGRB3 CALCRL ADGRA2	5.88e-04	60	51	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRB3 CALCRL ADGRA2	6.17e-04	61	51	3	PS50261
Domain	PLAC	ADAMTS19 PCSK6	6.51e-04	14	51	2	PF08686
Domain	BBOX	TRIM49 TRIM49C TRIM49B	8.85e-04	69	51	3	SM00336
Domain	-	TRIM49 TRIM49C TRIM49B	9.62e-04	71	51	3	4.10.45.10
Domain	zf-B_box	TRIM49 TRIM49C TRIM49B	1.00e-03	72	51	3	PF00643
Domain	Wnt	WNT10B WNT10A	1.21e-03	19	51	2	IPR005817
Domain	PLAC	ADAMTS19 PCSK6	1.21e-03	19	51	2	PS50900
Domain	Wnt_CS	WNT10B WNT10A	1.21e-03	19	51	2	IPR018161
Domain	wnt	WNT10B WNT10A	1.21e-03	19	51	2	PF00110
Domain	PLAC	ADAMTS19 PCSK6	1.21e-03	19	51	2	IPR010909
Domain	WNT1	WNT10B WNT10A	1.21e-03	19	51	2	SM00097
Domain	WNT1	WNT10B WNT10A	1.21e-03	19	51	2	PS00246
Domain	ZF_BBOX	TRIM49 TRIM49C TRIM49B	1.36e-03	80	51	3	PS50119
Domain	Znf_B-box	TRIM49 TRIM49C TRIM49B	1.41e-03	81	51	3	IPR000315
Domain	TRYPSIN_SER	PRSS27 CELA2A CELA2B	1.91e-03	90	51	3	IPR033116
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTS13	1.94e-03	24	51	2	IPR013273
Domain	HormR	ADGRB3 CALCRL	2.11e-03	25	51	2	SM00008
Domain	ACR	ADAMTS19 ADAMTS13	2.46e-03	27	51	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS19 ADAMTS13	2.46e-03	27	51	2	IPR006586
Domain	TRYPSIN_HIS	PRSS27 CELA2A CELA2B	2.80e-03	103	51	3	IPR018114
Domain	TRYPSIN_SER	PRSS27 CELA2A CELA2B	3.04e-03	106	51	3	PS00135
Domain	TRYPSIN_HIS	PRSS27 CELA2A CELA2B	3.12e-03	107	51	3	PS00134
Domain	Peptidase_S1A	PRSS27 CELA2A CELA2B	3.64e-03	113	51	3	IPR001314
Domain	TRYPSIN_DOM	PRSS27 CELA2A CELA2B	3.82e-03	115	51	3	PS50240
Domain	GPS	ADGRB3 ADGRA2	3.88e-03	34	51	2	SM00303
Domain	Tryp_SPc	PRSS27 CELA2A CELA2B	4.01e-03	117	51	3	SM00020
Domain	GPS	ADGRB3 ADGRA2	4.11e-03	35	51	2	PF01825
Domain	GPS	ADGRB3 ADGRA2	4.34e-03	36	51	2	PS50221
Domain	PTPc	PTPN6 PTPRN2	4.34e-03	36	51	2	SM00194
Domain	Trypsin	PRSS27 CELA2A CELA2B	4.40e-03	121	51	3	PF00089
Domain	Trypsin_dom	PRSS27 CELA2A CELA2B	4.40e-03	121	51	3	IPR001254
Domain	GPS	ADGRB3 ADGRA2	4.58e-03	37	51	2	IPR000203
Domain	Peptidase_S1_PA	PRSS27 CELA2A CELA2B	4.61e-03	123	51	3	IPR009003
Domain	TYR_PHOSPHATASE_PTP	PTPN6 PTPRN2	5.08e-03	39	51	2	PS50055
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS13	5.34e-03	40	51	2	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS13	5.34e-03	40	51	2	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS13	5.34e-03	40	51	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS13	5.34e-03	40	51	2	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS13	5.34e-03	40	51	2	IPR001590
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2A CELA2B	1.40e-04	7	37	2	MM1589
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SPON1 ADAMTS13	1.43e-04	39	37	3	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS19 SPON1 ADAMTS13	1.43e-04	39	37	3	MM15165
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PTPN6 YES1 IL5RA	1.66e-04	41	37	3	MM15162
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2A CELA2B	1.86e-04	8	37	2	M22084
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	PTPN6 YES1 IL5RA	2.65e-04	48	37	3	M914
Pathway	REACTOME_PECAM1_INTERACTIONS	PTPN6 YES1	4.35e-04	12	37	2	MM14835
Pathway	REACTOME_PECAM1_INTERACTIONS	PTPN6 YES1	4.35e-04	12	37	2	M11773
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	PTPN6 YES1	5.13e-04	13	37	2	MM14565
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS19 SPON1 ADAMTS13	7.42e-04	68	37	3	M27303
Pathway	REACTOME_REGULATION_OF_KIT_SIGNALING	PTPN6 YES1	7.86e-04	16	37	2	M537
Pathway	KEGG_ADHERENS_JUNCTION	PTPN6 CSNK2B YES1	9.12e-04	73	37	3	M638
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT10B WNT10A	1.11e-03	19	37	2	M47836
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM49 TRIM49C TRIM49B	1.50e-06	15	53	3	19703589
Pubmed	Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.	WNT10B WNT10A	2.28e-06	2	53	2	36833267
Pubmed	Murine Wnt10a and Wnt10b: cloning and expression in developing limbs, face and skin of embryos and in adults.	WNT10B WNT10A	2.28e-06	2	53	2	8875992
Pubmed	ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.	ANGPT4 CD163	2.28e-06	2	53	2	34146541
Pubmed	WNT10B mutations associated with isolated dental anomalies.	WNT10B WNT10A	2.28e-06	2	53	2	29364501
Pubmed	Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.	CELA2A CELA2B	2.28e-06	2	53	2	3646943
Pubmed	Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.	CELA2A CELA2B	2.28e-06	2	53	2	28386233
Pubmed	Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.	CELA2A CELA2B	2.28e-06	2	53	2	16327289
Pubmed	Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with the Wnt/β-catenin pathway.	WNT10B WNT10A	2.28e-06	2	53	2	23135473
Pubmed	Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.	ETV2 YES1	2.28e-06	2	53	2	31278282
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49 TRIM49C TRIM49B	3.18e-06	19	53	3	22144910
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS19 SPON1 ADGRB3 ADAMTS13	5.39e-06	75	53	4	20637190
Pubmed	Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.	CSNK2B CD163	6.83e-06	3	53	2	11298324
Pubmed	Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.	CELA2A CELA2B	6.83e-06	3	53	2	3427074
Pubmed	Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis.	WNT10B WNT10A	6.83e-06	3	53	2	30246922
Pubmed	ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.	ADAMTS19 ADAMTS13	1.36e-05	4	53	2	28088271
Pubmed	WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells.	WNT10B WNT10A	1.36e-05	4	53	2	11350055
Pubmed	Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.	WNT10B WNT10A	1.36e-05	4	53	2	21872687
Pubmed	Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.	PTPN6 IL5RA	1.36e-05	4	53	2	7768898
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	TCIRG1 LOXL4 TEP1 ADGRA2 RYR1	1.90e-05	214	53	5	22199357
Pubmed	Expression of Wnts in the developing murine secondary palate.	WNT10B WNT10A	2.27e-05	5	53	2	19598129
Pubmed	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.	CELA2A CELA2B	2.27e-05	5	53	2	20179351
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS19 ADAMTS13	4.76e-05	7	53	2	11867212
Pubmed	The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development.	CELA2A CELA2B	4.76e-05	7	53	2	2294404
Pubmed	Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.	CELA2A CELA2B	4.76e-05	7	53	2	3641189
Pubmed	FGF signaling refines Wnt gradients to regulate the patterning of taste papillae.	WNT10B WNT10A	6.34e-05	8	53	2	28506989
Pubmed	Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth.	WNT10B WNT10A	6.34e-05	8	53	2	9769173
Pubmed	Lineage-specific biology revealed by a finished genome assembly of the mouse.	TRIM49 TRIM49C TRIM49B	8.29e-05	55	53	3	19468303
Pubmed	Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.	WNT10B WNT10A	1.49e-04	12	53	2	27864382
Pubmed	Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.	PTPN6 REG3G	1.49e-04	12	53	2	27830702
Pubmed	Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.	WNT10B WNT10A	1.76e-04	13	53	2	22024319
Pubmed	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	PTPN6 ANGPT4 ALG10	2.34e-04	78	53	3	19204726
Pubmed	Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation.	WNT10B WNT10A	2.36e-04	15	53	2	15044261
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT10B WNT10A	2.36e-04	15	53	2	11429295
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA2A CELA2B	2.36e-04	15	53	2	24793170
Pubmed	Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.	WNT10B WNT10A	2.70e-04	16	53	2	19619491
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	CELA2A CELA2B	2.70e-04	16	53	2	19635472
Pubmed	The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.	CELA2A CELA2B	2.70e-04	16	53	2	9851981
Pubmed	The Wnts.	WNT10B WNT10A	2.70e-04	16	53	2	9889131
Pubmed	Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway.	WNT10B WNT10A	2.70e-04	16	53	2	26581094
Pubmed	Different roles of Runx2 during early neural crest-derived bone and tooth development.	WNT10B WNT10A	3.05e-04	17	53	2	16813524
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	EHMT1 NIPBL TASOR2	3.13e-04	86	53	3	37253089
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT10B WNT10A	3.83e-04	19	53	2	11520664
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SPON1 ADGRB3 EHMT1 ADGRA2	3.90e-04	225	53	4	12168954
Pubmed	A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis.	WNT10B WNT10A	4.25e-04	20	53	2	22234613
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	WNT10B WNT10A	4.70e-04	21	53	2	17943183
Pubmed	Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells.	WNT10B WNT10A	4.70e-04	21	53	2	19806668
Pubmed	Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis.	WNT10B WNT10A	4.70e-04	21	53	2	31914354
Pubmed	The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.	WNT10B WNT10A	4.70e-04	21	53	2	11914369
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	WNT10B WNT10A	5.16e-04	22	53	2	12815618
Pubmed	Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.	WNT10B WNT10A	5.16e-04	22	53	2	18991257
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT10B WNT10A	5.65e-04	23	53	2	27362799
Pubmed	The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation.	UPK3B REG3G	5.65e-04	23	53	2	19494835
Pubmed	The inductive role of Wnt-β-Catenin signaling in the formation of oral apparatus.	WNT10B WNT10A	5.65e-04	23	53	2	21600200
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	GPRASP1 ARMCX4	6.16e-04	24	53	2	16221301
Pubmed	Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.	WNT10B WNT10A	6.16e-04	24	53	2	19165927
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	WNT10B WNT10A	7.80e-04	27	53	2	17804636
Pubmed	Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.	GPRASP1 CSNK2B PCSK6	7.88e-04	118	53	3	21078624
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	WNT10B WNT10A	8.40e-04	28	53	2	20940229
Pubmed	Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.	WNT10B WNT10A	8.40e-04	28	53	2	24394376
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRB3 ADGRA2	9.01e-04	29	53	2	15203201
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	WNT10B WNT10A	9.01e-04	29	53	2	22956684
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	WNT10B WNT10A	9.01e-04	29	53	2	18364260
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	WNT10B WNT10A	9.64e-04	30	53	2	21936019
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	WNT10B WNT10A	9.64e-04	30	53	2	15880404
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	WNT10B WNT10A	9.64e-04	30	53	2	19282366
Pubmed	Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.	WNT10B WNT10A	9.64e-04	30	53	2	36305473
Pubmed	DNA-binding specificities of human transcription factors.	ZBED1 HOXB13	1.03e-03	31	53	2	23332764
Pubmed	The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.	WNT10B WNT10A	1.10e-03	32	53	2	25428587
Pubmed	Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.	WNT10B WNT10A	1.17e-03	33	53	2	27414999
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRB3 ADGRA2	1.17e-03	33	53	2	25713288
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HS2ST1 FNBP4 ADGRB3 EHMT1 ADGRA2	1.26e-03	529	53	5	14621295
Pubmed	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.	WNT10B WNT10A	1.31e-03	35	53	2	18676816
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	WNT10B WNT10A	1.31e-03	35	53	2	30940800
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	WNT10B WNT10A	1.31e-03	35	53	2	19185060
Pubmed	The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.	CELA2A CELA2B	1.39e-03	36	53	2	25063451
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	WNT10B WNT10A	1.47e-03	37	53	2	35831952
Pubmed	Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.	WNT10B WNT10A	1.47e-03	37	53	2	15342465
Cytoband	Xq22.1	GPRASP1 ARMCX4	1.15e-03	43	53	2	Xq22.1
Cytoband	1p36.21	CELA2A CELA2B	2.44e-03	63	53	2	1p36.21
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS19 ADAMTS13	7.97e-04	19	40	2	50
GeneFamily	Wnt family\|Endogenous ligands	WNT10B WNT10A	7.97e-04	19	40	2	360
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM49 TRIM49C TRIM49B	1.21e-03	95	40	3	59
GeneFamily	Ring finger proteins	TRIM49 RNF135 TRIM49C TRIM49B	3.11e-03	275	40	4	58
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPRASP1 ARMCX4	4.07e-03	43	40	2	409
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS19 ANGPT4 PCSK6 WNT10B CELA2A WNT10A REG3G LOXL4 ADAMTS13 CELA2B	1.92e-06	738	53	10	MM17058
Coexpression	NABA_MATRISOME_ASSOCIATED	ADAMTS19 ANGPT4 PCSK6 WNT10B CELA2A WNT10A REG3G LOXL4 ADAMTS13 CELA2B	2.25e-06	751	53	10	M5885
Coexpression	NABA_MATRISOME	ADAMTS19 SPON1 ANGPT4 PCSK6 WNT10B CELA2A WNT10A REG3G LOXL4 ADAMTS13 CELA2B	4.46e-06	1008	53	11	MM17056
Coexpression	NABA_MATRISOME	ADAMTS19 SPON1 ANGPT4 PCSK6 WNT10B CELA2A WNT10A REG3G LOXL4 ADAMTS13 CELA2B	5.28e-06	1026	53	11	M5889
Coexpression	NABA_ECM_REGULATORS	ADAMTS19 PCSK6 CELA2A LOXL4 ADAMTS13 CELA2B	8.46e-06	238	53	6	M3468
Coexpression	NABA_ECM_REGULATORS	ADAMTS19 PCSK6 CELA2A LOXL4 ADAMTS13 CELA2B	9.30e-06	242	53	6	MM17062
Coexpression	NABA_MATRISOME_HYPERPLASTIC_PANCREATIC_ISLETS	CELA2A REG3G CELA2B	1.96e-05	26	53	3	MM17051
Coexpression	GSE33162_UNTREATED_VS_4H_LPS_STIM_HDAC3_HET_MACROPHAGE_UP	FNBP4 ZFYVE26 CALCRL ARMCX4 ADGRA2	5.00e-05	198	53	5	M9035
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SPON1 UPK3B CLDN16 WNT10A RYR1	1.51e-06	164	53	5	08c725548e751f815b4df778607270498204b353
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN YES1 ADGRA2	2.80e-06	186	53	5	a906020a8df6fcca474b278f746c553b177a56b4
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Lpl_(Layer_2/3)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CD6 WNT10B ADAMTS13 TMEM235	4.44e-06	92	53	4	dfe63bb979f0382163955b32909ffab1de37685a
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP4 TAF2 ARMCX4 CD163	1.59e-05	127	53	4	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	MALRD1 ADGRB3 NKAIN2 RYR1	2.27e-05	139	53	4	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTPN6 CELA2A ZFYVE26 TEP1	4.03e-05	161	53	4	5a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	WNT10A LOXL4 ADAMTS13 RYR1	4.23e-05	163	53	4	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PRSS27 WNT10A ARMCX4 RYR1	4.23e-05	163	53	4	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	MALRD1 SPON1 ADGRB3 NKAIN2	4.44e-05	165	53	4	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	facs-Heart-RV-24m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 CD6 WNT10A IL5RA	4.65e-05	167	53	4	f72c0ec1bb682c20bfaab726f9ee17a5a00cf0b1
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRN2 SPON1 WNT10A IL5RA	4.87e-05	169	53	4	c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRN2 SPON1 WNT10A IL5RA	5.10e-05	171	53	4	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 TEP1 CD163 RYR1	5.22e-05	172	53	4	6b01448443cf8392ed8248ff452b80c31240b85d
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 TEP1 CD163 RYR1	5.22e-05	172	53	4	0c0ae2da3cba6022403434567800f16e61a34a2b
ToppCell	droplet-Fat-BAT+GAT+MAT-30m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 TEP1 CD163 RYR1	5.22e-05	172	53	4	d80c207f3489be2da2f40f47a7835cb73c949c3e
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 CELA2A WNT10A CD163	5.46e-05	174	53	4	84f2ffe867f22d2fa79f28737a0aa42bdf2f4804
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN6 CELA2A TEP1 RYR1	5.58e-05	175	53	4	3bca1aac2a2a1f46753b5f9462888f144ed8327b
ToppCell	facs-Marrow-T-cells-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON1 WNT10B WNT10A IL5RA	5.58e-05	175	53	4	0a01e0104cfa3091bc05b0f1d087c941688169a5
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR146 CALCRL NOSTRIN ARMCX4	5.71e-05	176	53	4	c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR146 CALCRL NOSTRIN ARMCX4	5.71e-05	176	53	4	d58ef51002ea50b3037636038214bbb7454cb503
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN6 ANGPT4 TCIRG1 CD163	5.96e-05	178	53	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	facs-Marrow-T-cells-24m-Hematologic-Unknown_Progenitor\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON1 WNT10B WNT10A IL5RA	6.09e-05	179	53	4	3f2934c5f8816a7b7a6aef8d2f83ebf7b2b693bf
ToppCell	368C-Endothelial_cells-Endothelial-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPR146 PCSK6 CALCRL NOSTRIN	6.23e-05	180	53	4	8ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	WNT10B CLDN16 LOXL4 ZBED1	6.23e-05	180	53	4	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	368C-Endothelial_cells-Endothelial-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPR146 PCSK6 CALCRL NOSTRIN	6.23e-05	180	53	4	394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 TMEM235 CALCRL NOSTRIN	6.64e-05	183	53	4	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 TMEM235 CALCRL NOSTRIN	6.64e-05	183	53	4	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPON1 WNT10A IL5RA RYR1	6.92e-05	185	53	4	238938a4682b44e88a30b86b13af4feeabe9553d
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgM_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PTPN6 PCSK6 EHMT1 WNT10A	6.92e-05	185	53	4	26ea60b6392410fab048f2e406a9860a018429cc
ToppCell	Endothelial-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	GPR146 CALCRL NOSTRIN ADGRA2	7.52e-05	189	53	4	04b565855f58ca0f343904d04be657b66e109076
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR146 PCSK6 CALCRL NOSTRIN	7.52e-05	189	53	4	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	PCW_05-06-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GPR146 PCSK6 CALCRL NOSTRIN	7.99e-05	192	53	4	f68e6cbde87678122da1b5c0061904cfb7d04bf5
ToppCell	LPS-IL1RA+antiTNF-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR146 CALCRL NOSTRIN YES1	7.99e-05	192	53	4	04f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR146 CALCRL NOSTRIN YES1	7.99e-05	192	53	4	c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALCRL NOSTRIN ARMCX4 ADGRA2	7.99e-05	192	53	4	5890076929598e88fe9d59a4e4e858b446746ce9
ToppCell	LPS-antiTNF-Endothelial-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR146 CALCRL NOSTRIN YES1	8.15e-05	193	53	4	02f633b016ab19bfa65bfd0cf32f000549a62148
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALCRL NOSTRIN ARMCX4 ADGRA2	8.15e-05	193	53	4	4a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCell	droplet-Liver-HEPATOCYTES-1m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CALCRL NOSTRIN ARMCX4 ADGRA2	8.15e-05	193	53	4	d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCell	LPS-antiTNF-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR146 CALCRL NOSTRIN YES1	8.15e-05	193	53	4	5122b1ffba42de190061be34ecdc6176f84e56a3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPON1 ADGRB3 CALCRL NOSTRIN	8.15e-05	193	53	4	1f978e102a029a6beb10913052cd0a20c7253e8e
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	GPR146 PCSK6 CALCRL NOSTRIN	8.32e-05	194	53	4	760f98bbcb669e599c389ef7892043eee3a05edf
ToppCell	PCW_05-06-Endothelial-Endothelial_immature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	GPR146 PCSK6 CALCRL NOSTRIN	8.32e-05	194	53	4	9bd25ea57f2da27bd200d1a8bf797fec77d172c7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 CALCRL NOSTRIN YES1	8.49e-05	195	53	4	818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	SPON1 PCSK6 ADGRB3 CALCRL	8.49e-05	195	53	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	medial-Endothelial-Capillary_Intermediate_2-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PTPRN2 CALCRL NOSTRIN YES1	8.65e-05	196	53	4	5cc14a5797884ff3a007683048e690a0d7172fc4
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	8.65e-05	196	53	4	889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell	medial-Endothelial-Capillary_Intermediate_2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PTPRN2 CALCRL NOSTRIN YES1	8.65e-05	196	53	4	07e6214e771c65574f0ada65e75f4bda265aa47f
ToppCell	medial-2-Endothelial-Capillary_Intermediate_2\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PTPRN2 CALCRL NOSTRIN YES1	8.65e-05	196	53	4	d074c24fecd0e3ffca4699fb1a9d443e6d9a858d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN YES1	8.65e-05	196	53	4	ed818de15f84f7f28bd06fd69d7876710da232a0
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	8.83e-05	197	53	4	62c0a90869431e582bb7bb329e0b0cc59123d3d1
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	8.83e-05	197	53	4	e567f91fa398fd306d025dcfe89bd50a60216537
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	8.83e-05	197	53	4	9e948b2e0f7e426f1e6f95bbbf4282fbddc2b99d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	8.83e-05	197	53	4	16f0eb047df9d702518f82ee99c6e7dc1350b2fb
ToppCell	metastatic_Brain-Endothelial_cells\|metastatic_Brain / Location, Cell class and cell subclass	GPR146 CALCRL NOSTRIN ADGRA2	9.00e-05	198	53	4	97ef7946ef11ac93318c1dd46b548dc01e5a6aba
ToppCell	metastatic_Brain-Endothelial_cells-Tumor_ECs\|metastatic_Brain / Location, Cell class and cell subclass	GPR146 CALCRL NOSTRIN ADGRA2	9.00e-05	198	53	4	5e274f29cc796dae7d64d6035e904816c25f9914
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CALCRL NOSTRIN YES1 ADGRA2	9.18e-05	199	53	4	9c40b3ee39860e9d8edafd007daec11abdd95435
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CALCRL NOSTRIN YES1 ADGRA2	9.18e-05	199	53	4	72b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR146 CALCRL NOSTRIN CD163	9.36e-05	200	53	4	e6d36be0c4c569e27303bb4e4f34cd2187e9759d
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Macrophages\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	GPR146 CALCRL NOSTRIN CD163	9.36e-05	200	53	4	c0c51719cf81512c50bfcc2fed883c867e522d2a
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPR146 CALCRL NOSTRIN CD163	9.36e-05	200	53	4	758840c31f2ddd7ccf7bf13252ebb48d33e89479
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GPR146 CALCRL NOSTRIN YES1	9.36e-05	200	53	4	58a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Glia_progenitor_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	TCIRG1 CALCRL TEP1 RYR1	9.36e-05	200	53	4	4b937b1d0179d1d0e51931f35720e205d460a07e
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR146 CALCRL NOSTRIN ADGRA2	9.36e-05	200	53	4	061ba851f941c616ddb462512e826c412881c3ce
ToppCell	Lung_Parenchyma-Severe-Myeloid-Macrophage-Macrophages\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPR146 CALCRL NOSTRIN CD163	9.36e-05	200	53	4	c37fe06a94e5779c56e01389869bb432d3bbaebc
ToppCell	TCGA-Testes-Primary_Tumor-Testicular_Germ_Cell_Tumor-Non-Seminoma-_Embryonal_Carcinoma,_Yolk_Sac_Tumor-1\|TCGA-Testes / Sample_Type by Project: Shred V9	TRIM49 ANGPT4 TRIM49C	2.81e-04	107	53	3	80afce55e410aed65b565d2f432cefa39dae313d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPON1 CLDN16 RYR1	4.54e-04	126	53	3	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPON1 ETV2 YES1	4.86e-04	129	53	3	6bc85761dea1f97c19bb379a99e4daf85d53201e
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature\|E16.5-samps / Age Group, Lineage, Cell class and subclass	RNF135 UPK3B LOXL4	4.86e-04	129	53	3	5e4783cc63afdeaebdfaecb72f95f3efc8d3c4a3
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Ptrf\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WNT10A ADAMTS13 CD163	5.31e-04	133	53	3	a1bc34e5dda4ff4716b857931cc196f6770f58f4
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CD6 UPK3B CLDN16	5.43e-04	134	53	3	72d7eec3aeb43319f3ef81bb5518fae8d8880136
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRB3 WNT10A TEP1	5.43e-04	134	53	3	0e3f37ef041b751ed45060b5ce39385a2731370b
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPON1 CLDN16 RYR1	5.43e-04	134	53	3	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	CELA2A CELA2B TASOR2	5.55e-04	135	53	3	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	healthy_donor-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)\|healthy_donor / Disease condition, Lineage, Cell class and subclass	MCHR1 WNT10A CALCRL	5.91e-04	138	53	3	97f5dc17522462133e582b508ad0ef036e656872
ToppCell	MS-CD4-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	FANK1 PCSK6 WNT10B	6.29e-04	141	53	3	df257dd4dcc45c1ace57340798e150a6e932531d
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PCSK6 WNT10A CD163	6.42e-04	142	53	3	5ef69032ed7dc5f2244b84e8c6662290bf59a34b
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN6 ADGRB3 ETV2	6.56e-04	143	53	3	4a0f26eef935fe68a1da5d319503059a8a8682dd
ToppCell	LPS-antiTNF-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPN6 ADGRB3 ETV2	6.56e-04	143	53	3	65328a0a2f3972fac596e07933e74b2ef7cceb84
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MCHR1 ADAMTS13 RYR1	6.56e-04	143	53	3	5fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCIRG1 TEP1 CD163	6.69e-04	144	53	3	f5d0d0564fcbec8a5d87119e0807b619faa77b0f
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WNT10A CD163 RYR1	7.24e-04	148	53	3	d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	CELA2A CELA2B TASOR2	7.39e-04	149	53	3	768877bade04ca0321593b8470b5011ad8270431
ToppCell	droplet-Fat-Scat-21m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEP1 CD163 RYR1	7.68e-04	151	53	3	79827a76c675dcb82f59c0a45d0f962b02d5bfd6
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	PTPRN2 ALG10 RYR1	7.82e-04	152	53	3	b8aa62e3cf2b4c252db4bccfa75d881c4fa0a788
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	WNT10A LOXL4 ADAMTS13	7.97e-04	153	53	3	a44da11a913b19edde6c5d1d6e625c24b20ecbfd
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	GPR146 ETV2 NOSTRIN	8.13e-04	154	53	3	1c62290a2558fd6401b27de5a867d243b143b00a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRB3 CALCRL NOSTRIN	8.28e-04	155	53	3	babcb9e548f04ace8157d506d27c5941c692c491
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-1\|TCGA-Prostate / Sample_Type by Project: Shred V9	FANK1 TCIRG1 NOSTRIN	8.28e-04	155	53	3	ef346599eb7847d4cd542cecc6d8260e8f200aad
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	CELA2A CELA2B CD163	8.43e-04	156	53	3	1a0e081284a99c1b345990775015b8a2fa469496
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS19 SPON1 ADGRB3	8.43e-04	156	53	3	895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCell	10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FANK1 CALCRL NKAIN2	8.43e-04	156	53	3	bb2876bdf2375866d7509eba3c48322326349fa8
ToppCell	facs-MAT-Fat-24m\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT4 CELA2A REG3G	8.43e-04	156	53	3	7433c6d4eb4d061844d8979c1e648d8ed56e1073
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_T_naive\|World / disease group, cell group and cell class (v2)	GPRASP1 CD6 LOXL4	8.59e-04	157	53	3	23879e65a6acc33d9aad096cd23604a77b0ac9c2
ToppCell	facs-GAT-Fat-24m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD6 ANGPT4 IL5RA	8.59e-04	157	53	3	c4a0b6c95d353691fd2846002ce4bc7c2b0edd1c
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	PTPRN2 NKAIN2 RYR1	8.91e-04	159	53	3	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT4 UPK3B CD163	8.91e-04	159	53	3	c9e093d7c1dca83f6546adaf3d874929e2cea612
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_OR1J1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRIM49 CALCRL CD163	9.07e-04	160	53	3	0c4e50aae25aa8f567a661778d89cf385c914ae0
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	ADGRB3 CALCRL NOSTRIN	9.07e-04	160	53	3	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5_FEZF2_DYRK2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPON1 REG3G CALCRL	9.07e-04	160	53	3	e2504c6deba4949a3a716a9ca68755f787bc0ae0
ToppCell	facs-Heart-LA-24m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT4 CELA2A REG3G	9.24e-04	161	53	3	248487415a0601d57ef2a6692e22a61368d0b9c8
Drug	nifedipine; Up 200; 10uM; MCF7; HG-U133A	CD6 MCHR1 SPON1 HS2ST1 CALCRL NIPBL	5.37e-06	199	51	6	603_UP
Disease	tooth agenesis (is_implicated_in)	WNT10B WNT10A	1.26e-04	10	50	2	DOID:0050591 (is_implicated_in)
Disease	Oligodontia	WNT10B WNT10A	1.84e-04	12	50	2	C4082304
Disease	Hypodontia	WNT10B WNT10A	2.53e-04	14	50	2	C0020608
Disease	developmental dysplasia of the hip	REG3G LOXL4	3.33e-04	16	50	2	EFO_1000648
Disease	cervical cancer (is_marker_for)	PTPN6 HOXB13	1.71e-03	36	50	2	DOID:4362 (is_marker_for)
Disease	response to radiation, prostate carcinoma, erectile dysfunction	CELA2A CELA2B	1.80e-03	37	50	2	EFO_0001663, EFO_0004234, GO_0009314

Protein segments in the cluster

Peptide	Gene	Start	Entry
WASGEWECTVSMAQG	ADGRA2	321	Q96PE1
MAQTGESGVEEWSQW	ADGRB3	286	O60242
SAGFLIVATWTDCWM	CLDN16	16	Q9Y5I7
WWGSSVKTSMICAGG	CELA2A	191	P08217
FQTMDGDWENSVSWA	ARMCX4	1116	Q5H9R4
WHVGTWMECSVSCGD	ADAMTS13	1076	Q76LX8
CEGQDCMTVWEAGVW	ADAMTS19	1031	Q8TE59
TVADFWQMVWESGCV	PTPRN2	826	Q92932
MLEHGEWGSVCDDTW	CD6	176	P30203
WGSVCSENWGLTEAM	LOXL4	446	Q96JB6
EGFTNWEFMTVHCWG	PCSK6	581	P29122
SVQWMAGSYSGSWTE	NIPBL	2736	Q6KC79
SWWMENGPGCTVTSV	NKAIN2	106	Q5VXU1
SEVGWTHMEAAAVWG	OPN4	416	Q9UHM6
MCEWTSEASAGQISW	MALRD1	276	Q5VYJ5
AVSSMCREAGLWSEW	IL5RA	311	Q01344
CSSSGWWGSTVKTNM	CELA2B	186	P08218
WWGSTVKTNMICAGG	CELA2B	191	P08218
QVMSGGWWFDACGLS	ANGPT4	446	Q9Y264
MSSSEEVSWISWFCG	CSNK2B	1	P67870
WEQATGTGWMDLEAS	MCHR1	61	Q99705
MWSCSWFNGTGLVEE	GPR146	1	Q96CH1
PWSGDWTDMACTAWD	ETV2	86	O00321
WTDMACTAWDSWSGA	ETV2	91	O00321
SWALAGGWNSQMCCQ	HOXB13	171	Q92826
EWGTVCNNGWSMEAV	CD163	71	Q86VB7
LQEDATGEACWWTMH	RYR1	136	P21817
VNCQDDGGWTPMIWA	EHMT1	866	Q9H9B1
GWLCWNDVAAGTESM	CALCRL	71	Q16602
DGDGWEWSSTDVMNY	REG3G	116	Q6UW15
SCVSSAWAWASEGMK	NOSTRIN	66	Q8IVI9
WAADGGHCSVIEWMI	FANK1	216	Q8TC84
GSWFWTEEEASMGTG	GPRASP1	436	Q5JY77
NCSHWAVGVASWEMS	RNF135	321	Q8IUD6
DEDGSTCTMSEWITW	SPON1	496	Q9HCB6
MTEWGEWDECSATCG	SPON1	561	Q9HCB6
HVGDSWNWAFGVCNM	TRIM49	346	P0CI25
EMGDWQEVWDENTGC	FNBP4	216	Q8N3X1
GCFISRMSWSDEWVL	TAF2	356	Q6P1X5
SECWNVGSRWAMDQA	HS2ST1	226	Q7LGA3
WIFGWSEHVVCSIGM	ALG10	81	Q5BKT4
CSAGPVWDDMLHWQA	UBE2DNL	21	Q8IWF7
RVSFGWSMALAWGSC	TMEM235	171	A6NFC5
AKCSPEGEWTTGNMW	TEP1	2491	Q99973
IFETGMNCWVTGWGS	PRSS27	151	Q9BQR3
MNCWVTGWGSPSEED	PRSS27	156	Q9BQR3
HVGDSWNWAFGVCNM	TRIM49C	346	P0CI26
GCLEATVNDFWQMAW	PTPN6	326	P29350
GWVSWSDSMQADSET	nan	91	Q8NA96
NQEDWGCSSWVPGME	TASOR2	1876	Q5VWN6
HVGDSWNWAFGVCNM	TRIM49B	346	A6NDI0
QDSWEWGGCSPDMGF	WNT10A	206	Q9GZT5
QDTWEWGGCNHDMDF	WNT10B	191	O00744
ATWCGISTDMWRSEN	ZBED1	191	O96006
LSLGEWGSWMDASSQ	UPK3B	26	Q9BT76
WGSWMDASSQTQGAG	UPK3B	31	Q9BT76
DTTGAWHAWGMACLK	ZFYVE26	2061	Q68DK2
WSVAAMANQSGWSDA	TCIRG1	476	Q13488
GCFGEVWMGTWNGTT	YES1	286	P07947
SGDHMCISVDSWWAD	LEG1	116	Q6P5S2