Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentextracellular matrix

THSD4 PRSS3 RELN ZAN ADAMTS10 S100A8 TGM3 PRG3 PTPRZ1 LPA GPC4 PLAT CLEC3B ADAMTS14 MMP9

9.87e-0665612615GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THSD4 PRSS3 RELN ZAN ADAMTS10 S100A8 TGM3 PRG3 PTPRZ1 LPA GPC4 PLAT CLEC3B ADAMTS14 MMP9

1.02e-0565812615GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

THSD4 PRSS3 RELN ADAMTS10 S100A8 TGM3 PRG3 PTPRZ1 LPA GPC4 PLAT CLEC3B MMP9

1.94e-0553012613GO:0062023
GeneOntologyCellularComponentaxonemal dynein complex

DNAH12 DNAI4 DNAH6

4.46e-04251263GO:0005858
GeneOntologyCellularComponentserine protease inhibitor complex

PLAT PLAU

5.32e-0461262GO:0097180
MousePhenodecreased susceptibility to induced choroidal neovascularization

LPA PLAT PLAU NOS2

5.64e-07101034MP:0003434
MousePhenochoroidal neovascularization

LPA PLAT PLAU NOS2

9.90e-06191034MP:0005546
MousePhenoabnormal choroid vasculature morphology

LPA PLAT PLAU NOS2

4.28e-05271034MP:0006237
DomainKringle-like

MRC1 LPA PLAT PLAU MMP9

2.25e-06321265IPR013806
DomainuDENN

DENND4B DENND2C DENND5A

1.03e-04141263SM00800
DomainuDENN

DENND4B DENND2C DENND5A

1.29e-04151263PF03456
DomainVDCC_T_a1

CACNA1I CACNA1G

1.35e-0431262IPR005445
DomainDENN

DENND4B DENND2C DENND5A

1.57e-04161263SM00799
DomainDENN

DENND4B DENND2C DENND5A

1.57e-04161263PF02141
DomaindDENN

DENND4B DENND2C DENND5A

1.57e-04161263PF03455
DomainUDENN

DENND4B DENND2C DENND5A

1.57e-04161263PS50946
DomainDDENN

DENND4B DENND2C DENND5A

1.57e-04161263PS50947
DomaindDENN

DENND4B DENND2C DENND5A

1.57e-04161263SM00801
DomaindDENN_dom

DENND4B DENND2C DENND5A

1.57e-04161263IPR005112
DomainuDENN_dom

DENND4B DENND2C DENND5A

1.57e-04161263IPR005113
DomainDENN

DENND4B DENND2C DENND5A

1.57e-04161263PS50211
DomainDENN_dom

DENND4B DENND2C DENND5A

1.57e-04161263IPR001194
DomainKringle_CS

LPA PLAT PLAU

1.90e-04171263IPR018056
DomainCarb_anhydrase

CA12 PTPRG PTPRZ1

1.90e-04171263PF00194
DomainCarb_anhydrase

CA12 PTPRG PTPRZ1

1.90e-04171263SM01057
DomainKRINGLE_1

LPA PLAT PLAU

1.90e-04171263PS00021
Domain-

CA12 PTPRG PTPRZ1

1.90e-041712633.10.200.10
DomainKR

LPA PLAT PLAU

1.90e-04171263SM00130
DomainKringle

LPA PLAT PLAU

1.90e-04171263IPR000001
DomainALPHA_CA_2

CA12 PTPRG PTPRZ1

1.90e-04171263PS51144
DomainKRINGLE_2

LPA PLAT PLAU

1.90e-04171263PS50070
DomainKringle

LPA PLAT PLAU

1.90e-04171263PF00051
DomainCarbonic_anhydrase_a

CA12 PTPRG PTPRZ1

1.90e-04171263IPR001148
DomainPLAC

THSD4 ADAMTS10 ADAMTS14

2.68e-04191263PS50900
DomainPLAC

THSD4 ADAMTS10 ADAMTS14

2.68e-04191263IPR010909
DomainFN3

OBSCN TYRO3 IL22RA2 PTPRG PTPRZ1 FNDC8 EPHA5

4.07e-041991267PS50853
DomainDOCK_N

DOCK3 DOCK4

4.46e-0451262PF16172
DomainDOCK_N

DOCK3 DOCK4

4.46e-0451262IPR032376
DomainGST_mu

GSTM1 GSTM5

4.46e-0451262IPR003081
DomainADAM_spacer1

THSD4 ADAMTS10 ADAMTS14

4.81e-04231263IPR010294
DomainADAM_spacer1

THSD4 ADAMTS10 ADAMTS14

4.81e-04231263PF05986
DomainFN3_dom

OBSCN TYRO3 IL22RA2 PTPRG PTPRZ1 FNDC8 EPHA5

5.45e-042091267IPR003961
DomainProt-tyrosine_phosphatase-like

DUSP12 MTMR8 PTPRG PTPRZ1 TNS3

5.56e-04991265IPR029021
DomainPTPc_motif

MTMR8 PTPRG PTPRZ1 TNS3

6.75e-04591264SM00404
DomainTyr_Pase_cat

MTMR8 PTPRG PTPRZ1 TNS3

6.75e-04591264IPR003595
Domainfn3

OBSCN TYRO3 PTPRG PTPRZ1 FNDC8 EPHA5

8.12e-041621266PF00041
DomainFN3

OBSCN TYRO3 PTPRG PTPRZ1 FNDC8 EPHA5

1.61e-031851266SM00060
DomainVDCCAlpha1

CACNA1I CACNA1G

1.96e-03101262IPR002077
Domain-

ADAMTS10 MME ADAMTS14 MMP9

2.20e-038112643.40.390.10
DomainMetalloPept_cat_dom

ADAMTS10 MME ADAMTS14 MMP9

2.20e-03811264IPR024079
DomainDHR-1_domain

DOCK3 DOCK4

2.39e-03111262IPR027007
DomainDHR_2

DOCK3 DOCK4

2.39e-03111262PS51651
DomainDHR_1

DOCK3 DOCK4

2.39e-03111262PS51650
DomainDHR-2

DOCK3 DOCK4

2.39e-03111262PF06920
DomainDOCK

DOCK3 DOCK4

2.39e-03111262IPR026791
DomainDOCK_C

DOCK3 DOCK4

2.39e-03111262IPR010703
DomainDOCK-C2

DOCK3 DOCK4

2.39e-03111262PF14429
DomainDHR-2

DOCK3 DOCK4

2.39e-03111262IPR027357
DomainTYR_PHOSPHATASE_1

DUSP12 MTMR8 PTPRG PTPRZ1

2.74e-03861264PS00383
DomainABC_A

ABCA3 ABCA10

2.85e-03121262IPR026082
DomainC-type_lectin_CS

MRC1 PRG3 CLEC3B

3.04e-03431263IPR018378
DomainF-box-like

FBXW12 ECT2L FBXO44

3.24e-03441263PF12937
DomainTTL

TTLL5 TTLL4

3.35e-03131262PS51221
DomainTTL/TTLL_fam

TTLL5 TTLL4

3.35e-03131262IPR004344
Domain-

MRC1 MMP9

3.35e-031312622.10.10.10
DomainTTL

TTLL5 TTLL4

3.35e-03131262PF03133
Domain-

DUSP12 PTPRG PTPRZ1 TNS3

3.49e-039212643.90.190.10
DomainDynein_heavy_chain_D4_dom

DNAH12 DNAH6

3.90e-03141262IPR024317
DomainFN_type2_col-bd

MRC1 MMP9

3.90e-03141262IPR000562
DomainFN2_2

MRC1 MMP9

3.90e-03141262PS51092
DomainDynein_heavy_dom-2

DNAH12 DNAH6

3.90e-03141262IPR013602
DomainDHC_N2

DNAH12 DNAH6

3.90e-03141262PF08393
DomainATPase_dyneun-rel_AAA

DNAH12 DNAH6

3.90e-03141262IPR011704
DomainFN2_1

MRC1 MMP9

3.90e-03141262PS00023
DomainPLAC

THSD4 ADAMTS10

3.90e-03141262PF08686
DomainAAA_8

DNAH12 DNAH6

3.90e-03141262PF12780
Domainfn2

MRC1 MMP9

3.90e-03141262PF00040
DomainFN2

MRC1 MMP9

3.90e-03141262SM00059
DomainAAA_5

DNAH12 DNAH6

3.90e-03141262PF07728
DomainPROTEIN_KINASE_TYR

OBSCN TYRO3 ALK EPHA5

4.22e-03971264PS00109
DomainTyr_kinase_AS

OBSCN TYRO3 ALK EPHA5

4.22e-03971264IPR008266
DomainZINC_PROTEASE

ADAMTS10 MME ADAMTS14 MMP9

4.38e-03981264PS00142
DomainDHC_fam

DNAH12 DNAH6

4.48e-03151262IPR026983
DomainDynein_heavy

DNAH12 DNAH6

4.48e-03151262PF03028
DomainDynein_heavy_dom

DNAH12 DNAH6

4.48e-03151262IPR004273
DomainMAM_1

ZAN ALK

5.09e-03161262PS00740
DomainFBOX

FBXW12 ECT2L FBXO44

5.21e-03521263SM00256
DomainTRYPSIN_HIS

PRSS3 LPA PLAT PLAU

5.22e-031031264IPR018114
DomainDUF1605

DHX33 DHX29

5.75e-03171262IPR011709
DomainOB_NTP_bind

DHX33 DHX29

5.75e-03171262PF07717
DomainTRYPSIN_SER

PRSS3 LPA PLAT PLAU

5.78e-031061264PS00135
DomainTRYPSIN_HIS

PRSS3 LPA PLAT PLAU

5.97e-031071264PS00134
DomainMAM

ZAN ALK

6.44e-03181262PF00629
DomainMAM_dom

ZAN ALK

6.44e-03181262IPR000998
DomainHA2

DHX33 DHX29

6.44e-03181262SM00847
DomainMAM_2

ZAN ALK

6.44e-03181262PS50060
DomainHA2

DHX33 DHX29

6.44e-03181262PF04408
DomainHelicase-assoc_dom

DHX33 DHX29

6.44e-03181262IPR007502
PathwayKEGG_MEDICUS_VARIANT_TMPRSS2_ERG_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION

PLAT PLAU MMP9

1.15e-057993M47443
PathwayBIOCARTA_FIBRINOLYSIS_PATHWAY

LPA PLAT PLAU

7.06e-0512993MM1398
PathwayBIOCARTA_PLATELETAPP_PATHWAY

LPA PLAT PLAU

1.16e-0414993MM1458
PathwayREACTOME_DISSOLUTION_OF_FIBRIN_CLOT

LPA PLAT PLAU

1.44e-0415993MM15450
PathwayPID_AMB2_NEUTROPHILS_PATHWAY

LPA PLAT PLAU MMP9

1.90e-0441994M159
Pubmed

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.

LPA PLAT PLAU MMP9

2.87e-096131415841177
Pubmed

Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.

LPA PLAT PLAU

2.08e-074131319210287
Pubmed

Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice.

PLAT PLAU MMP9

2.08e-074131315631996
Pubmed

Plasmin is essential in preventing periodontitis in mice.

LPA PLAT PLAU

2.08e-074131321704601
Pubmed

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

PLAT PLAU MMP9

2.08e-074131314617754
Pubmed

Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.

PLAT PLAU MMP9

2.08e-074131321802414
Pubmed

Plasminogen activator induction facilitates recovery of respiratory function following spinal cord injury.

LPA PLAT PLAU

2.08e-074131318042398
Pubmed

Mice lacking tPA, uPA, or plasminogen genes showed delayed functional recovery after sciatic nerve crush.

LPA PLAT PLAU

2.08e-074131311404420
Pubmed

Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.

LPA PLAT PLAU

2.08e-074131319286661
Pubmed

Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice.

LPA PLAT PLAU

2.08e-074131321931850
Pubmed

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

LPA PLAT PLAU

2.08e-074131316763560
Pubmed

Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.

LPA PLAT MMP9

5.19e-075131317596135
Pubmed

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.

LPA PLAT MMP9

5.19e-075131327283026
Pubmed

Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization.

LPA PLAT PLAU

5.19e-075131312657615
Pubmed

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection.

LPA PLAT PLAU

5.19e-075131312875972
Pubmed

The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.

LPA PLAT PLAU

5.19e-075131311818362
Pubmed

Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.

LPA PLAT PLAU

5.19e-075131311306532
Pubmed

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system.

LPA PLAT PLAU

5.19e-075131310880388
Pubmed

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.

PLAT PLAU MMP9

1.04e-066131310502816
Pubmed

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice.

LPA PLAT PLAU

1.04e-066131310318667
Pubmed

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation.

PLAT PLAU MMP9

1.04e-06613139398846
Pubmed

Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.

LPA PLAT PLAU

2.88e-06813139438420
Pubmed

The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice.

LPA PLAT PLAU

2.88e-068131325893677
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

PEG10 DHX33 ZCCHC3 S100A8 NAT10 GPC4 USP7 NUP153 MOV10

7.52e-06349131925665578
Pubmed

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

LPA PLAT PLAU

8.43e-0611131326647393
Pubmed

Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy.

THSD4 SLC6A4 MMP9

8.43e-0611131321491160
Pubmed

Pemphigus vulgaris and pemphigus foliaceus antibodies are pathogenic in plasminogen activator knockout mice.

PLAT PLAU

1.41e-052131210417613
Pubmed

Polyglutamylation is a post-translational modification with a broad range of substrates.

TTLL5 TTLL4

1.41e-052131218045879
Pubmed

The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation.

PLAT PLAU

1.41e-052131216601837
Pubmed

Role of double knockdown of tPA and MMP-9 on regulating the left ventricular function and remodeling followed by transverse aortic constriction-induced hypertrophic cardiomyopathy in mice.

PLAT MMP9

1.41e-052131230323866
Pubmed

A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.

PTPRG PLAU

1.41e-05213128453613
Pubmed

Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases.

PTPRG PLAU

1.41e-05213128382771
Pubmed

Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.

IFIT1 IFIT1B

1.41e-052131223824812
Pubmed

A viral RNA structural element alters host recognition of nonself RNA.

IFIT1 IFIT1B

1.41e-052131224482115
Pubmed

Regulation of proteinases during mouse peri-implantation development: urokinase-type plasminogen activator expression and cross talk with matrix metalloproteinase 9.

PLAU MMP9

1.41e-052131221075828
Pubmed

Influence of t-pA and u-PA on adipose tissue development in a murine model of diet-induced obesity.

PLAT PLAU

1.41e-052131211858492
Pubmed

IL-1beta stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells.

PLAT PLAU

1.41e-052131218202522
Pubmed

The influence of opioid peptides on matrix metalloproteinase-9 and urokinase plasminogen activator expression in three cancer cell lines.

PLAU MMP9

1.41e-052131223350235
Pubmed

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.

IFIT1 IFIT1B

1.41e-052131225927359
Pubmed

IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages.

IFIT1 IFIT1B

1.41e-052131230282041
Pubmed

Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator.

PLAT PLAU

1.41e-052131212356640
Pubmed

Regulation of plasminogen activators in human thyroid follicular cells and their relationship to differentiated function.

PLAT PLAU

1.41e-052131217458906
Pubmed

Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice.

PLAT PLAU

1.41e-052131220856796
Pubmed

Mechanism of the synergistic effect between oversulfated chondroitin-6-sulfate and lysine or 6-aminohexanoic acid in enhancing the in-vitro activation of glutamic plasminogen by tissue plasminogen activator or urokinase.

PLAT PLAU

1.41e-052131220445443
Pubmed

Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse.

PLAT PLAU

1.41e-05213122821634
Pubmed

Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway.

IFIT1 IFIT1B

1.41e-052131226459629
Pubmed

Genetic analysis of the plasminogen and coagulation system in mice.

PLAT PLAU

1.41e-05213128979118
Pubmed

Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.

IFIT1 IFIT1B

1.41e-052131233454014
Pubmed

Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model.

PLAT PLAU

1.41e-052131212719778
Pubmed

Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice.

PLAT PLAU

1.41e-05213129351457
Pubmed

Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients.

PRSS3 SLC6A4

1.41e-052131218363639
Pubmed

Increased bone formation in mice lacking plasminogen activators.

PLAT PLAU

1.41e-052131212854826
Pubmed

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.

ERCC6 PGBD3

1.41e-052131222483866
Pubmed

Tissue plasminogen activator in the bed nucleus of stria terminalis regulates acoustic startle.

PLAT PLAU

1.41e-052131216125860
Pubmed

Identification and validation of Ifit1 as an important innate immune bottleneck.

IFIT1 IFIT1B

1.41e-052131222745654
Pubmed

Tissue-type plasminogen activator (tPA) interacts with urokinase-type plasminogen activator (uPA) via tPA's lysine binding site. An explanation of the poor fibrin affinity of recombinant tPA/uPA chimeric molecules.

PLAT PLAU

1.41e-05213127721771
Pubmed

Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo.

PLAT PLAU

1.41e-052131211238111
Pubmed

Plasminogen activators are involved in the degradation of bone by osteoclasts.

PLAT PLAU

1.41e-052131218691680
Pubmed

Plasminogen activators direct reorganization of the liver lobule after acute injury.

PLAT PLAU

1.41e-052131211238040
Pubmed

Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease.

GSTM1 MMP9

1.41e-052131215085249
Pubmed

What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?

ERCC6 PGBD3

1.41e-052131223369858
Pubmed

Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis.

PLAU MMP9

1.41e-052131216880329
Pubmed

Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2).

GSTM1 GSTM5

1.41e-05213122689439
Pubmed

Plasminogen activator expression correlates with genetic differences in vascular remodeling.

PLAT PLAU

1.41e-052131215528930
Pubmed

Secretions of MMP-9 by soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) mediated by protein kinase C (PKC)delta and phospholipase D (PLD) in murine macrophage.

PRKCD MMP9

1.41e-052131215156560
Pubmed

Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion.

PLAU MMP9

1.41e-052131218355442
Pubmed

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

PLAT PLAU

1.41e-05213128647936
Pubmed

Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses.

CACNA1I CACNA1G

1.41e-052131226627919
Pubmed

Overexpression of IFIT1 protects against LPS-induced acute lung injury via regulating CCL5-p65NF-κB signaling.

IFIT1 IFIT1B

1.41e-052131236446235
Pubmed

Pi-class glutathione-S-transferase-positive hepatocytes in aging B6C3F1 mice undergo apoptosis induced by dietary restriction.

GSTM1 GSTM5

1.41e-05213128909248
Pubmed

DNA methylation is associated with altered gene expression in AMD.

GSTM1 GSTM5

1.41e-052131222410570
Pubmed

Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.

ERCC6 PGBD3

1.41e-052131221143350
Pubmed

The association between expression of IFIT1 in podocytes of MRL/lpr mice and the renal pathological changes it causes: An animal study.

IFIT1 IFIT1B

1.41e-052131227823966
Pubmed

Role of laminin in matrix induction of macrophage urokinase-type plasminogen activator and 92-kDa metalloproteinase expression.

PLAU MMP9

1.41e-05213129079647
Pubmed

Characterization of the murine plasminogen/urokinase-type plasminogen-activator system.

PLAT PLAU

1.41e-05213128944773
Pubmed

Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.

MMP9 NOS2

1.41e-052131217071581
Pubmed

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

IFIT1 IFIT1B

1.41e-052131224098121
Pubmed

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.

PLAT MMP9

1.41e-052131212438450
Pubmed

Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator.

PLAT PLAU

1.41e-052131216127152
Pubmed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence.

GSTM1 NOS2

1.41e-052131219996333
Pubmed

Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families.

IFIT1 IFIT1B

1.41e-052131226157117
Pubmed

Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury.

MMP9 NOS2

1.41e-052131219443702
Pubmed

An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.

ERCC6 PGBD3

1.41e-052131218369450
Pubmed

Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation.

RELN PLAT

1.41e-052131224892761
Pubmed

Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia.

PLAT MMP9

1.41e-052131216051896
Pubmed

2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.

IFIT1 IFIT1B

1.41e-052131222589727
Pubmed

Genomic organization and characterization of the promoter region of murine GSTM2 gene.

GSTM1 GSTM5

1.41e-052131211404019
Pubmed

Tissue-type plasminogen activator deficiency exacerbates arthritis.

PLAT PLAU

1.41e-052131211441114
Pubmed

Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes.

VSNL1 HPCAL4

1.41e-052131210520747
Pubmed

Sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system.

PLAT PLAU

1.41e-052131215629242
Pubmed

Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis.

PLAT PLAU

1.41e-052131211891190
Pubmed

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.

PLAU MME

1.41e-052131215615772
Pubmed

Physiological consequences of loss of plasminogen activator gene function in mice.

PLAT PLAU

1.41e-05213128133887
Pubmed

Mice deficient in urokinase-type plasminogen activator have delayed healing of tympanic membrane perforations.

PLAT PLAU

1.41e-052131223236466
Pubmed

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.

IFIT1 IFIT1B

1.41e-052131227240734
Pubmed

Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis.

PLAU MMP9

1.41e-052131220584616
Pubmed

Progesterone regulation of glutathione S-transferase Mu2 expression in mouse uterine luminal epithelium during preimplantation period.

GSTM1 GSTM5

1.41e-052131218692819
Pubmed

GSTM1 and GSTM5 Genetic Polymorphisms and Expression in Age-Related Macular Degeneration.

GSTM1 GSTM5

1.41e-052131225897651
Pubmed

Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro.

PRKCD NOS2

1.41e-052131219931912
Pubmed

Hypoxia enhances gene expression of inducible nitric oxide synthase and matrix metalloproteinase-9 in ras/myc-transformed serum-free mouse embryo cells under simulated inflammatory and infectious conditions.

MMP9 NOS2

1.41e-052131218474440
Cytoband10p12.33

MRC1 ST8SIA6

2.24e-048131210p12.33
GeneFamilyFibronectin type III domain containing

OBSCN TYRO3 PTPRG PTPRZ1 FNDC8 EPHA5

1.57e-04160916555
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND4B DENND2C DENND5A

2.62e-0425913504
GeneFamilyCalcium voltage-gated channel subunits

CACNA1I CACNA1G CACNA2D3

2.95e-0426913253
GeneFamilyTubulin tyrosine ligase family

TTLL5 TTLL4

2.19e-0314912779
GeneFamilyATP binding cassette subfamily A

ABCA3 ABCA10

2.19e-0314912805
GeneFamilyDEAH-box helicases

DHX33 DHX29

2.87e-0316912500
GeneFamilyDyneins, axonemal

DNAH12 DNAH6

3.24e-0317912536
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS10 ADAMTS14

4.05e-031991250
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRG PTPRZ1

4.94e-0321912813
CoexpressionGSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_DN

CA12 ABCA3 IFIT1 CEMIP PTPRZ1 DNAI4 DENND5A TNS3

5.53e-061941298M8864
CoexpressionNABA_MATRISOME

THSD4 PRSS3 RELN TSPEAR ADAMTS10 S100A8 TGM3 PRG3 LPA SLIT3 GPC4 PLAT PLAU CLEC3B ADAMTS14 MMP9 FNDC8

9.51e-06100812917MM17056
CoexpressionKRAS.600_UP.V1_UP

DOCK4 RELN MTMR8 PRG3 PLAT PLAU MMP9 FNDC8 KCNAB3

1.04e-052791299M2882
CoexpressionNABA_MATRISOME

THSD4 PRSS3 RELN TSPEAR ADAMTS10 S100A8 TGM3 PRG3 LPA SLIT3 GPC4 PLAT PLAU CLEC3B ADAMTS14 MMP9 FNDC8

1.20e-05102612917M5889
CoexpressionNABA_ECM_REGULATORS

PRSS3 ADAMTS10 TGM3 LPA PLAT PLAU ADAMTS14 MMP9

2.44e-052381298M3468
CoexpressionNABA_ECM_REGULATORS

PRSS3 ADAMTS10 TGM3 LPA PLAT PLAU ADAMTS14 MMP9

2.74e-052421298MM17062
CoexpressionBOQUEST_STEM_CELL_UP

PEG10 GAS7 GSTM5 PTPRG AGL SLIT3 GPC4 MME

4.69e-052611298M1834
CoexpressionGSE360_LOW_DOSE_B_MALAYI_VS_M_TUBERCULOSIS_DC_DN

CA12 PSMA3 S100A8 GPC4 RRH DENND5A MMP9

5.99e-051991297M5230
CoexpressionBURTON_ADIPOGENESIS_9

GALK2 GSTM1 GPC4 PRKCD PLAT

6.39e-05851295M1666
CoexpressionKRAS.600.LUNG.BREAST_UP.V1_UP

DOCK4 PRSS3 RELN MTMR8 PRG3 MMP9 FNDC8 KCNAB3

7.67e-052801298M2886
CoexpressionBURTON_ADIPOGENESIS_9

GALK2 GSTM1 GPC4 PRKCD PLAT

7.96e-05891295MM1026
CoexpressionGARCIA_PINERES_PBMC_HPV_16_L1_VLP_AGE_18_25YO_2MO_DN

ACADVL POLD1 GAS7 S100A8 EHHADH LPA CLEC3B CACNA2D3

9.10e-052871298M40958
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN TNFAIP8L3 ZAN PEG10 PTPRZ1 GPC4 GRIN3A

3.44e-0715213178ff5a178a8f3550d89a003c0858820aab3773386
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ARSI ST8SIA6 TECPR2 GPC4 PLAU CACNA1G

4.86e-07160131756e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ARSI ST8SIA6 TECPR2 GPC4 PLAU CACNA1G

4.86e-071601317bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-0717313175b76d9cc56bbb29017e64a2d0a3c76c0be003d96
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-071731317bf685025961e79b379f2c35464b6c8ce3e31ace0
ToppCellBAL-Severe-Myeloid-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-071731317a6e73a40b0d5356564a594053e772f9d061a5919
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-071731317a8b5370f4c893a20c58e97659f3ac168699693f8
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil-Neu_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-0717313171edef5aeab626cbf2c09468e77b02cfa2d21ba03
ToppCellBAL-Severe-Myeloid-Neutrophil-Neutrophil|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

8.22e-071731317c37dba3804df7c3151e18e6ae4e0b6e7a92bae97
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 MRC1 RELN TRIM62 PLAU ZSCAN2 CACNA2D3

8.88e-0717513170801cccec6915aefc135262fc74580280fd51aa5
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 MRC1 RELN TRIM62 PLAU ZSCAN2 CACNA2D3

8.88e-07175131709163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THSD4 PRSS3 RELN STAP2 ST8SIA6 DNAH6 HPCAL4

9.23e-071761317460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCellSevere_COVID-19-Myeloid-Neutrophil|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU MMP9

9.59e-071771317a6fae376f1beb1df423484d9b1bd1d954ca117af
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 PRSS3 VSNL1 CEMIP S100A8 PTPRZ1 PLAT

1.20e-061831317bbf27d2f4369031fadacacd6c432c06b1ec5abdb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN TNFAIP8L3 ST8SIA6 GRIN3A ALK PALLD TNS3

1.38e-061871317d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 DOCK3 TTLL5 USP24 IFIT1 TTLL4 PALLD

1.43e-0618813176468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 DOCK3 TTLL5 USP24 IFIT1 TTLL4 PALLD

1.43e-0618813177a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 DOCK3 TTLL5 USP24 IFIT1 TTLL4 PALLD

1.43e-0618813179cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN TNFAIP8L3 ST8SIA6 PTPRZ1 GRIN3A ALK TNS3

1.43e-061881317ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RELN TYRO3 SLIT3 GPC4 WSCD2 MME PALLD

1.77e-0619413171374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 GAS7 ABCA10 SLIT3 MME SH3RF3 PALLD

2.16e-062001317e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte|GW12 / Sample Type, Dataset, Time_group, and Cell type.

THSD4 FBXW12 POLD1 USP24 RDH12 PLAU SH3RF3

2.16e-062001317b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COLGALT2 TGM3 SLIT3 GPC4 LRATD2 MMP9

3.13e-0613613161f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN TGM3 SLIT3 GPC4 LRATD2 MMP9

3.70e-0614013167cc891d676555609add6fc7880735d948a2ad801
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN TNFAIP8L3 ZAN PEG10 PTPRZ1 GRIN3A

5.10e-0614813165e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN RAPSN IFIT1 GSTM1 GRIN3A ALK

6.41e-061541316a2adaa4a6cd8708cd579b8efbeb4ff2131c5482e
ToppCellCOVID-CD4-antiviral_CD4|COVID / Condition, Cell_class and T cell subcluster

MTMR8 COLGALT2 IFIT1 NAT10 CACNA1I DNAH6

6.65e-0615513167e5ae034036fe85915d38a24195501e6d3bcbfb0
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_large-bowel / Manually curated celltypes from each tissue

INPP5A NAT10 LRATD2 MMP9 NUDT15 HPCAL4

6.90e-06156131601f2c0c6a936dfb59bc727feef428a906ad2a80b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

GSTM1 TYRO3 LINC02902 GYS1 PRKCD TNS3

7.16e-0615713162c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ARSI LDHD ST8SIA6 GPC4 CACNA1G

8.26e-06161131660f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MRC1 RELN STAP2 PLAU MMP9 FNDC8

8.87e-061631316c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MRC1 RELN STAP2 PLAU MMP9 FNDC8

8.87e-0616313165d49414432db259a19df50d7944581d00b69f537
ToppCellfacs-Trachea-nan-18m-Myeloid-granulocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERV3-1 SLC6A4 S100A8 MMP9 FNDC8 KCNAB3

9.84e-0616613167f8b4cf63c3e292ae421f111edaa4572717f4db1
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

THSD4 ZNF492 RELN DHX33 IFIT1 WSCD2

1.24e-051731316b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellfacs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTM1 LDHD EHHADH GPC4 CNDP2 MME

1.33e-051751316076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCellfacs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTM1 LDHD EHHADH GPC4 CNDP2 MME

1.33e-051751316445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN TNFAIP8L3 TSPEAR STAP2 CEMIP NOS2

1.42e-05177131676f5df101c693e5fa61554244d877fc8169ee66f
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SPR STAP2 DCSTAMP ADAMTS14 MMP9 PALLD

1.46e-051781316a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCellSevere-Myeloid-Neutrophil|Severe / Condition, Lineage, Cell class and cell subclass

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU

1.46e-051781316454313efe59d71e7327b9758efabf2d893e4a8fd
ToppCellSevere-Myeloid-Neutrophil-|Severe / Condition, Lineage, Cell class and cell subclass

ERV3-1 IFIT1 S100A8 TGM3 TECPR2 PLAU

1.46e-0517813168618ae891d62bf70fe860ff7bb2d31868961aa13
ToppCelldroplet-Limb_Muscle-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB GSTM1 S100A8 CNDP2 PLAT CLEC3B

1.51e-051791316013818e173101efca7625ccd4258e60655815d73
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DOCK3 COLGALT2 PTPRG SH3RF3 ALK CACNA2D3

1.51e-05179131614fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 INPP5A ADGRL1 ZSCAN2 CACNA1G PALLD

1.56e-051801316a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD4 INPP5A ADGRL1 ZSCAN2 CACNA1G PALLD

1.56e-05180131663a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA12 INPP5A TTLL5 MFSD6 TTLL4 KCNAB3

1.56e-051801316be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA12 INPP5A TTLL5 MFSD6 TTLL4 KCNAB3

1.56e-0518013163b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA12 SLIT3 WSCD2 MME HPCAL4 CACNA2D3

1.66e-051821316d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA12 SLIT3 WSCD2 MME HPCAL4 CACNA2D3

1.66e-0518213166cde859edfe7607bd7ada89d20258413d06f4207
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 DOCK3 VSNL1 ADAMTS10 SLIT3 PALLD

1.71e-0518313167eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellMild_COVID-19-Myeloid-MoAM4|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

GAS7 TTLL4 PLAU CACNA1G MMP9 TNS3

1.76e-05184131663ef6ba6ac33c3032735008ce3b411636ab3c395
ToppCelldroplet-Marrow-nan-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEXB STAP2 GSTM1 S100A8 TBRG1 GYS1

1.82e-0518513163dcafbd02b65a2befbb6e6288cb2591e721cddb6
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 VSNL1 STAP2 PTPRZ1 AGL PLAT

1.82e-051851316e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTM1 SLIT3 PLAT CLEC3B SH3RF3 CACNA2D3

1.88e-051861316cc94e0c5d1665d2ea2bb871ad79d8e1ec2249fb5
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SPR STAP2 DCSTAMP ADAMTS14 MMP9 PALLD

1.88e-051861316c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCell10x5'v1-week_17-19-Myeloid_macrophage-stroma-osteoclast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SPR STAP2 DCSTAMP ADAMTS14 MMP9 PALLD

1.99e-051881316762b52f21d2bc5409f86746a904c4358490be9c0
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSTM1 SLIT3 CNDP2 PLAT PLAU CLEC3B

2.05e-0518913166e52cac679e0541ca5f2be316bdabdbc34da6e18
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

THSD4 MRC1 SIN3B RELN TNFAIP8L3 TSPEAR

2.11e-0519013169ce301841ce9486701fa28eb2a9929e35d476878
ToppCell10x5'v1-week_12-13-Myeloid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SPR STAP2 DCSTAMP ADAMTS14 MMP9 PALLD

2.18e-051911316be2fe2583bdcee0b35c43a347da9c4adb93e30e0
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SPR STAP2 DCSTAMP ADAMTS14 MMP9 PALLD

2.18e-0519113164cebaf31d4f09f4ab273a819ad5cbff7d9a9b341
ToppCellfacs-Skin-Anagen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CA12 SLC6A4 TGM3 IL22RA2 PTPRZ1 ADAMTS14

2.24e-051921316ec1fd2fb6e71f87189d66261909a84e2be63cacb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 DOCK4 PTPRG ST8SIA6 PLAT TMEM184B

2.24e-0519213163259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 S100A8 PLAT PLAU NOS2 PALLD

2.31e-051931316463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCellBronchial_Biopsy-Immune-Luminal_Macrophages|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

HEXB MRC1 DCSTAMP S100A8 MME TNS3

2.45e-0519513166800c17026ec6c56132bf4664b8fcd74d7836579
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VSNL1 S100A8 TGM3 MME MMP9

2.50e-051171315089793a950e8593b4acc1ba6a5e5474682f5fda6
ToppCellPBMC-Mild-Myeloid-Neutrophil-Neutrophil-Neu_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VSNL1 S100A8 TGM3 MME MMP9

2.50e-0511713153d98d77b4725d684e7496059e8b0ffffbe40301d
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DOCK4 GAS7 CLEC3B MME PALLD TNS3

2.52e-05196131654f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 DOCK4 RELN PTPRG ST8SIA6 PLAT

2.52e-0519613168f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 DOCK4 RELN PTPRG ST8SIA6 PLAT

2.52e-05196131648b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 DOCK4 RELN PTPRG ST8SIA6 PLAT

2.52e-051961316473980c827443464d08a0be28c53e3536369b12a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RELN TYRO3 SLIT3 GPC4 WSCD2 PALLD

2.52e-051961316545d2e4469924d333e3f655f559c899fa1260196
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRSS3 VSNL1 S100A8 PTPRZ1 DENND2C PLAT

2.59e-051971316fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L DNAH12 DNAI4 C11orf97 DNAH6 PALLD

2.59e-05197131691637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L DNAH12 DNAI4 C11orf97 DNAH6 PALLD

2.59e-05197131622c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 MRC1 DCSTAMP S100A8 MMP9 TNS3

2.59e-0519713163912301018d0863144dcfac8d1fa8adc081748d7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ABCA10 CEMIP SLIT3 SH3RF3 PALLD

2.59e-051971316ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ABCA10 CEMIP SLIT3 SH3RF3 PALLD

2.59e-05197131637f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L DNAH12 DNAI4 C11orf97 DNAH6 PALLD

2.59e-0519713163bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRSS3 VSNL1 S100A8 PTPRZ1 DENND2C PLAT

2.59e-05197131661c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ECT2L DNAH12 DNAI4 C11orf97 DNAH6 PALLD

2.59e-05197131687db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 VSNL1 CEMIP S100A8 DENND2C PLAU

2.59e-0519713162430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 VSNL1 CEMIP PTPRZ1 DENND2C PLAT

2.74e-051991316c88a28a73f54dc571f2ff1e4b55073f83cbead2c
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CA12 STAP2 S100A8 PTPRZ1 AGL PLAT

2.74e-051991316ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12|Neuronal / cells hierarchy compared to all cells using T-Statistic

RELN ST8SIA6 PTPRZ1 GRIN3A ALK TNS3

2.82e-052001316c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

RELN ST8SIA6 PTPRZ1 GRIN3A ALK TNS3

2.82e-052001316ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCellwk_20-22-Mesenchymal-Fibroblast-intermediate_fibro|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PEG10 ABCA10 ARSI GSTM5 PLAT PALLD

2.82e-052001316d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCellCaecum-Macrophage-Macrophage|Caecum / Region, Cell class and subclass

DOCK4 MRC1 GAS7 S100A8 PLAU CACNA2D3

2.82e-05200131699dcf07b17ecf90d596f3b8a12d5b7aae2a351d5
ToppCellCaecum-(6)_Macrophage-(60)_Macrophage|Caecum / shred on region, Cell_type, and subtype

DOCK4 MRC1 GAS7 S100A8 PLAU CACNA2D3

2.82e-05200131667b6cdeb07ffc5c9af7a3e738dd31256cf391e98
ToppCellCaecum-(6)_Macrophage|Caecum / shred on region, Cell_type, and subtype

DOCK4 MRC1 GAS7 S100A8 PLAU CACNA2D3

2.82e-0520013162ce3930645c3daf6be578f7881e57a58df61e75c
ToppCellCaecum-Macrophage|Caecum / Region, Cell class and subclass

DOCK4 MRC1 GAS7 S100A8 PLAU CACNA2D3

2.82e-052001316d83209559187a4419df2508ecc5eb9f7d72fced3
ToppCellwk_15-18-Mesenchymal-Fibroblast-intermediate_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PEG10 ABCA10 ARSI GSTM5 PLAT PALLD

2.82e-0520013166461d25fd8fb52921b188f083fbe808535d3130b
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPSF4L IFIT1 PTPRG ST8SIA6 DNAH6

3.44e-05125131535042ed43045dddc341b76cc5f9fe31b5ba0abb8
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S100A8 CASD1 AGL MMP9 DHX29

4.62e-051331315f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

S100A8 CASD1 AGL MMP9 DHX29

4.62e-051331315292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh|GI_small-bowel / Manually curated celltypes from each tissue

MTMR8 IFIT1 DNAH12 DNAI4 CACNA1I

4.79e-051341315bf94ce5edde8912a27010e229c313d8102d6de62
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

RELN IFIT1 GSTM1 GRIN3A ALK

5.14e-051361315e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RELN IL17RE DENND2C MME NUDT15

5.51e-051381315611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PRSS3 IFIT1 S100A8 MME MMP9

5.70e-051391315fa0eedebf53317928022c3bed391ce99a2114f98
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cacng4_(Non-anterior_nuclei)|Thalamus / BrainAtlas - Mouse McCarroll V32

TSPEAR ARSI IL17RE PRKCD

7.49e-057613144afc8d0e79870c635a89dd8e7ca91ebfe482b4ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA10 CEMIP ADAMTS10 SH3RF3 PALLD

8.18e-0515013151270f33f9d7e46e55adf1a96e8beee858b95589d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ABCA10 CEMIP ADAMTS10 SH3RF3 PALLD

8.18e-051501315156118ce1d69522624196410cba18b8354cd0bb4
Drugdermatan sulfate

HEXB MRC1 PRSS3 ERCC6 ARSI PRG3 PTPRZ1 GPC4 MMP9 PGBD3

5.22e-0722012910CID000032756
Drughyaluronan

HEXB PRSS3 ERCC6 PRG3 PTPRZ1 GPC4 PLAT PLAU MMP9 PGBD3

2.63e-0626312910CID000024759
Drugguanosine 3',5'-cyclic monophosphoric acid

VSNL1 TNFAIP8L3 PEG10 RNF17 PHKG2 RRH PRKCD CACNA1I PLAU CACNA1G MME MMP9 NOS2 CACNA2D3

5.19e-0657712914CID000000295
Drugethanol

CA12 PRSS3 TNFAIP8L3 POLD1 PEG10 GSTM1 SLC6A4 GSTM5 LDHD GYS1 PRKCD PLAT CACNA1I PLAU CLEC3B GRIN3A NOS2

5.21e-0683712917CID000000702
DrugVinblastine

ABCA3 GAS7 S100A8 PRKCD PLAT PLAU TMEM97 MME NUDT15

1.84e-052611299ctd:D014747
DrugTAPAP

PRSS3 PLAT PLAU

2.07e-05101293CID000126363
Drugbis(4-hydroxycinnamoyl)methane

PRKCD PLAU MMP9 NOS2

2.40e-05301294ctd:C034786
DrugLovastatin

ERCC6 PSMA3 XIAP LPA PRKCD PLAT MMP9 NOS2

2.78e-052111298ctd:D008148
Drugtranexamic acid

LPA PLAT PLAU CLEC3B NOS2

3.15e-05641295CID000005526
Drugperhydrodiazepine

SLC6A4 NOS2

3.19e-0521292CID012680363
Drugxylosides

PLAU MMP9

3.19e-0521292ctd:C010807
Drugazotochelin

ERCC6 PGBD3

3.19e-0521292CID000193592
DiseaseVasogenic Brain Edema

PLAU MMP9 NOS2

3.80e-0681223C0750969
DiseaseCytotoxic Brain Edema

PLAU MMP9 NOS2

3.80e-0681223C0750970
DiseaseCytotoxic Cerebral Edema

PLAU MMP9 NOS2

3.80e-0681223C0472388
DiseaseVasogenic Cerebral Edema

PLAU MMP9 NOS2

3.80e-0681223C0472387
DiseaseBrain Edema

PLAU MMP9 NOS2

3.80e-0681223C1527311
DiseaseCerebral Edema

PLAU MMP9 NOS2

3.80e-0681223C0006114
DiseaseGlycogen Storage Disease

PHKG2 AGL GYS1 SLC37A4

4.53e-06271224C0017919
DiseaseThromboembolism

LPA PLAT PLAU

1.48e-05121223C0040038
DiseaseAmphetamine-Related Disorders

DCSTAMP GSTM1 SLC6A4 PLAT SH3RF3

1.52e-05751225C0236733
DiseaseAmphetamine Abuse

DCSTAMP GSTM1 SLC6A4 PLAT SH3RF3

1.52e-05751225C0236807
DiseaseAmphetamine Addiction

DCSTAMP GSTM1 SLC6A4 PLAT SH3RF3

1.52e-05751225C0236804
DiseaseIntracranial Embolism and Thrombosis

PLAT PLAU

1.70e-0521222C0007781
DiseaseCerebral Embolism and Thrombosis

PLAT PLAU

1.70e-0521222C0877855
DiseaseBrain Embolism and Thrombosis

PLAT PLAU

1.70e-0521222C0936247
DiseaseCholesterol Embolism

PLAT PLAU

1.70e-0521222C0149649
Diseasebrain edema (biomarker_via_orthology)

PLAT PLAU MMP9

3.03e-05151223DOID:4724 (biomarker_via_orthology)
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

ERCC6 PTPRZ1 PLAT MMP9 NOS2

4.32e-05931225DOID:3525 (biomarker_via_orthology)
DiseaseGlycogen storage disease

PHKG2 AGL SLC37A4

4.49e-05171223cv:C0017919
Diseasebacteriemia

DOCK3 PTPRG PALLD

4.49e-05171223EFO_0003033
DiseaseArterial Occlusive Diseases

PLAT PLAU

5.07e-0531222C0003838
DiseaseAcute Cerebrovascular Accidents

LPA PLAT PLAU NOS2

7.50e-05541224C0751956
Diseasefree cholesterol to total lipids in large HDL percentage

RAPSN GSTM1 LPA MMP9

8.65e-05561224EFO_0022279
Diseasegestational age, birth measurement

RAPSN INPP5A CACNA2D3

8.69e-05211223EFO_0005112, EFO_0006921
DiseaseDeep Vein Thrombosis

LPA PLAT PLAU

8.69e-05211223C0149871
DiseaseVenous Thrombosis

LPA PLAT PLAU

8.69e-05211223C0042487
Diseasesaturated fatty acids to total fatty acids percentage

RAPSN GSTM1 LPA

8.69e-05211223EFO_0022305
DiseaseAtherosclerosis

GSTM1 LPA PLAT NOS2

1.06e-04591224C0004153
DiseaseAtherogenesis

GSTM1 LPA PLAT NOS2

1.06e-04591224C1563937
DiseaseBrain Ischemia

PLAT PLAU MMP9 NOS2

1.13e-04601224C0007786
DiseaseCerebral Ischemia

PLAT PLAU MMP9 NOS2

1.13e-04601224C0917798
DiseaseCerebrovascular accident

LPA PLAT PLAU NOS2

1.29e-04621224C0038454
Diseasecolon adenocarcinoma (is_marker_for)

CA12 MMP9 NOS2

1.48e-04251223DOID:234 (is_marker_for)
Diseasemacular degeneration (is_marker_for)

ERCC6 GSTM1 MMP9

1.67e-04261223DOID:4448 (is_marker_for)
DiseasePosterior Fossa Hemorrhage

PLAT PLAU

1.68e-0451222C0751893
Diseaserenal hypertension (implicated_via_orthology)

MMP9 NOS2

1.68e-0451222DOID:1073 (implicated_via_orthology)
Diseaseperitonitis (is_implicated_in)

PLAT PLAU

1.68e-0451222DOID:8283 (is_implicated_in)
DiseaseBrugada syndrome (implicated_via_orthology)

GSTM1 GSTM5

1.68e-0451222DOID:0050451 (implicated_via_orthology)
DiseaseIntracranial Hemorrhage

PLAT PLAU

1.68e-0451222C0151699
DiseaseCerebral Hemorrhage

PLAT PLAU MMP9

2.09e-04281223C2937358
Diseaselarynx cancer (is_implicated_in)

ERCC6 GSTM1

2.52e-0461222DOID:2596 (is_implicated_in)
Diseasepulmonary emphysema (biomarker_via_orthology)

MMP9 NOS2

2.52e-0461222DOID:9675 (biomarker_via_orthology)
Diseasepulmonary hypertension (is_implicated_in)

SLC6A4 MMP9 NOS2

2.58e-04301223DOID:6432 (is_implicated_in)
DiseaseSchizophrenia

DOCK4 RELN VSNL1 INPP5A GSTM1 SLC6A4 PTPRZ1 SLIT3 PLAT GRIN3A MMP9 ALK

3.06e-0488312212C0036341
DiseaseAsthma

GSTM1 PLAU MMP9 NOS2

3.45e-04801224C0004096
Diseaseangle-closure glaucoma (is_implicated_in)

GSTM1 MMP9

3.51e-0471222DOID:13550 (is_implicated_in)
DiseaseMiddle Cerebral Artery Embolus

PLAT PLAU MMP9

3.76e-04341223C0751845
DiseaseEmbolic Infarction, Middle Cerebral Artery

PLAT PLAU MMP9

3.76e-04341223C0751847
DiseaseLeft Middle Cerebral Artery Infarction

PLAT PLAU MMP9

3.76e-04341223C0751846
DiseaseRight Middle Cerebral Artery Infarction

PLAT PLAU MMP9

3.76e-04341223C0751849
DiseaseThrombotic Infarction, Middle Cerebral Artery

PLAT PLAU MMP9

3.76e-04341223C0751848
DiseaseMiddle Cerebral Artery Occlusion

PLAT PLAU MMP9

3.76e-04341223C0740391
DiseaseInfarction, Middle Cerebral Artery

PLAT PLAU MMP9

3.76e-04341223C0740392
DiseaseMiddle Cerebral Artery Thrombosis

PLAT PLAU MMP9

3.76e-04341223C0740376
DiseaseMiddle Cerebral Artery Syndrome

PLAT PLAU MMP9

3.76e-04341223C0238281
DiseaseBone neoplasms

PLAU MMP9

4.67e-0481222C0005967
Diseaseresponse to statin, low density lipoprotein cholesterol measurement

CEMIP LPA

4.67e-0481222EFO_0004611, GO_0036273
DiseaseMalignant Bone Neoplasm

PLAU MMP9

4.67e-0481222C0279530
DiseaseReperfusion Injury

PLAT PLAU MMP9 NOS2

5.18e-04891224C0035126
Diseasesleep duration, low density lipoprotein cholesterol measurement

RAPSN USP24 SLC6A4 LPA

5.63e-04911224EFO_0004611, EFO_0005271
DiseaseMarfan Syndrome, Type I

MMP9 NOS2

5.99e-0491222C4721845
DiseaseMyocardial Infarction

PLAT PLAU MMP9 NOS2

6.62e-04951224C0027051
Diseaseautistic disorder (is_implicated_in)

RELN GSTM1 SLC6A4

7.04e-04421223DOID:12849 (is_implicated_in)
Diseasechronic obstructive pulmonary disease (is_marker_for)

GSTM1 PLAU MMP9 NOS2

7.16e-04971224DOID:3083 (is_marker_for)
DiseaseAlzheimer's disease (is_marker_for)

RELN ACADVL LPA PLAU MMP9 NOS2

7.17e-042571226DOID:10652 (is_marker_for)
DiseaseBrain hemorrhage

PLAT PLAU

7.47e-04101222C0553692
Diseaseosteonecrosis (is_implicated_in)

GSTM1 PLAT

7.47e-04101222DOID:10159 (is_implicated_in)
Diseaseliver cirrhosis (is_implicated_in)

GSTM1 SLC6A4 PHKG2

7.54e-04431223DOID:5082 (is_implicated_in)
Diseasemyocardial infarction (is_implicated_in)

LPA PLAT PLAU MMP9

7.73e-04991224DOID:5844 (is_implicated_in)
Diseasesciatic neuropathy (biomarker_via_orthology)

PLAT CACNA1I PLAU MMP9

7.73e-04991224DOID:11446 (biomarker_via_orthology)
Diseasestatus epilepticus (biomarker_via_orthology)

RELN PTPRZ1 PLAU MMP9

8.03e-041001224DOID:1824 (biomarker_via_orthology)
DiseasePosterior Choroidal Artery Infarction

PLAT PLAU

9.10e-04111222C0887799
DiseaseCerebral Infarction, Left Hemisphere

PLAT PLAU

9.10e-04111222C0751010
DiseaseAnterior Choroidal Artery Infarction

PLAT PLAU

9.10e-04111222C0751012
DiseaseCerebral Infarction, Right Hemisphere

PLAT PLAU

9.10e-04111222C0751011
DiseaseSubcortical Infarction

PLAT PLAU

9.10e-04111222C0751014
DiseaseCerebral Infarction

PLAT PLAU

9.10e-04111222C0007785
Diseasethoracic aortic aneurysm (is_implicated_in)

THSD4 MMP9

9.10e-04111222DOID:14004 (is_implicated_in)
DiseaseMarfan Syndrome

MMP9 NOS2

9.10e-04111222C0024796
Diseasepulmonary emphysema (is_implicated_in)

GSTM1 MMP9

9.10e-04111222DOID:9675 (is_implicated_in)
Diseaseobstructive sleep apnea (is_implicated_in)

SLC6A4 MMP9

9.10e-04111222DOID:0050848 (is_implicated_in)
DiseaseThrombus

TYRO3 PLAT PLAU

9.19e-04461223C0087086
Diseasediabetic maculopathy

USP7 ALK

1.09e-03121222EFO_0010133
DiseasePathological accumulation of air in tissues

ABCA3 NOS2

1.09e-03121222C0013990
DiseasePulmonary Thromboembolisms

PLAT PLAU

1.09e-03121222C0524702
DiseasePulmonary Embolism

PLAT PLAU

1.09e-03121222C0034065
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

RAPSN USP7

1.09e-03121222OBA_2045152
DiseaseThrombosis

TYRO3 PLAT PLAU

1.11e-03491223C0040053
Diseaselung disease (implicated_via_orthology)

MMP9 NOS2

1.28e-03131222DOID:850 (implicated_via_orthology)
DiseaseErythrocyte Mean Corpuscular Hemoglobin Test

ACADVL AGL

1.28e-03131222C0369183
Diseaseosteitis deformans

DCSTAMP GSTM5

1.28e-03131222EFO_0004261
Diseasebronchiolitis obliterans (is_marker_for)

MMP9 NOS2

1.28e-03131222DOID:2799 (is_marker_for)
DiseaseFinding of Mean Corpuscular Hemoglobin

ACADVL AGL

1.28e-03131222C1261502
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

RAPSN USP24 GSTM1 SLC6A4 PMPCA LPA

1.36e-032911226EFO_0008317, EFO_0020946
DiseaseLiver Cirrhosis, Experimental

GSTM1 AGL PRKCD PLAT PLAU MME MMP9 TMEM184B NOS2 SLC37A4

1.43e-0377412210C0023893
Diseaseskin melanoma (is_implicated_in)

GSTM1 MMP9

1.49e-03141222DOID:8923 (is_implicated_in)
DiseaseDiabetic Neuralgia

MME MMP9

1.49e-03141222C0751074
DiseaseDiabetic Neuropathies

MME MMP9

1.49e-03141222C0011882
DiseaseHypothermia, natural

PRKCD NOS2

1.49e-03141222C0020672
DiseaseAsymmetric Diabetic Proximal Motor Neuropathy

MME MMP9

1.49e-03141222C0271674
DiseaseSymmetric Diabetic Proximal Motor Neuropathy

MME MMP9

1.49e-03141222C0271673

Protein segments in the cluster

PeptideGeneStartEntry
YWRGCNKIKSKGFPR

PTPRG

761

P23470
YRQLPAKWSGACVLG

ERV3-1

426

Q14264
KPAFKSQDCPWYDQG

CPSF4L

116

A6NMK7
KFLGYCPQENSLWPK

ABCA10

1281

Q8WWZ4
GKWHLGFYRKECLPT

ARSI

146

Q5FYB1
GAWCKDPLQAGDRIY

ADGRL1

161

O94910
SLIWRCGYSKAKQDP

EPHA5

616

P54756
SYWCGKPRAVAGKEE

ABCA3

491

Q99758
NAFILQGPKYKWICA

ECT2L

866

Q008S8
NPSFEKVPVGRYWKC

DHX29

396

Q7Z478
NFNKGDWIRVGLCYP

CEMIP

1071

Q8WUJ3
IDKGWCYKRVCVPFG

ADAMTS10

526

Q9H324
FKGHCIWKSPEQTYG

ADAMTS14

536

Q8WXS8
PCKAAELVNNYGKGW

RAPSN

186

Q13702
YSIVCLWASFGDPKK

RRH

256

O14718
GKPIRFGYKFWCGAT

ERCC6

756

P0DP91
RGKKWYSSPLLFCFE

ERCC6

946

P0DP91
FTQLCIDLGWKPKYG

NOS2

286

P35228
PLSGKYFSDCKRTWV

RDH12

276

Q96NR8
LGDKYACWYQQKPGQ

IGLV3-1

46

P01715
SDKKWGFCPDQGYSL

MMP9

381

P14780
ELKQWYKGFLKDCPS

HPCAL4

26

Q9UM19
YYQGKCLTWKGPRRQ

NCR3

161

O14931
KLYSEFLGKRPWFAG

GSTM5

136

P46439
WGLRCLKEQGYDPFK

NUDT15

136

Q9NV35
WCGMYNRFDKGLQPK

MTMR8

496

Q96EF0
KDFVWGLNKQGYKCR

PRKCD

176

Q05655
DDCWNGKGKSRYLFA

GPC4

421

O75487
RKKCPFQSWPEAYGS

IL17RE

256

Q8NFR9
NSWSKKYPSCGGLLQ

CA12

41

O43570
CELGRFGQKTGKGWY

EHHADH

566

Q08426
PDKKWVFACGTYSRT

FBXW12

241

Q6X9E4
FPQDYFPECKWSRKG

INPP5A

151

Q14642
MKRFLGPCGWKYENI

DCSTAMP

231

Q9H295
KDWFAARPDCGSKYQ

FBXO44

161

Q9H4M3
DKTKPLWHNYFLCGL

GALK2

101

Q01415
TDFFKYACGGWLKRN

MME

81

P08473
YACGGWLKRNVIPET

MME

86

P08473
VGKWECPFDEKGLVY

DNAH12

1816

Q6ZR08
KRGWKLQVSYDCRAP

PEG10

586

Q86TG7
LGFSGQLFKKWRDCP

LMLN2

311

A0A1B0GTW7
AWCRYGKREFKIGGE

LRATD2

206

Q96KN1
PGCRTLAKYGQRQWK

IL22RA2

91

Q969J5
EKGRRKCDQYWPADG

PTPRZ1

1831

P23471
CSAPFWGVVADRFKK

MFSD6

116

Q6ZSS7
DNCAFRLYGHWVKKG

PHKG2

351

P15735
ARPSVLWCYKKELGF

NAT10

51

Q9H0A0
WFLVKEGCYPASAGK

RELN

1331

P78509
KWYRVVPCGKRSFAV

GRIN3A

906

Q8TCU5
KWCYGNNVLRPGDKY

OBSCN

3216

Q5VST9
TCRVAGNPKPKIYWF

PALLD

1021

Q8WX93
KGGYWRRAQCDKQLP

PRG3

206

Q9Y2Y8
QYQWLEKVFGSCPRK

PSMG1

146

O95456
CGKVLRKWFEPSQFG

SLC37A4

121

O43826
ERKKFGPLGWNICYE

DNAH6

3701

Q9C0G6
WPLSKCFELKGNVYE

CASD1

581

Q96PB1
FNKGKSWEFGIPLCR

DOCK3

1301

Q8IZD9
LEKCDGWYRGFALKN

DOCK4

36

Q8N1I0
IFGKKCYLGDTWNRL

CACNA1G

141

O43497
SAKGFFRQYPGIKWE

CACNA2D3

216

Q8IZS8
GKKCYLGDTWNRLDF

CACNA1I

141

Q9P0X4
ELFPWRGYCSQKAKG

LDHD

11

Q86WU2
GWALAKCGGKNYERA

IFIT1B

146

Q5T764
WARCKVLYINGFTDP

LINC02902

111

Q6ZTY9
YRTFKNLGGNKDWCK

DHX33

566

Q9H6R0
IPGTNKWAGLEKNYC

LPA

1756

P08519
KWAGLEKNYCRNPDG

LPA

1761

P08519
TGHTYKFPCGRWLGK

DENND5A

1036

Q6IQ26
SNPEKWCPKDFGVRY

DENND2C

36

Q68D51
EDGSRWFGYCKKLLP

DENND2C

566

Q68D51
GWALLKCGGKNYERA

IFIT1

146

P09914
YRDFRGGQKKGWCTT

DNAI4

21

Q5VTH9
WGPAVYLCYKVGLAK

DENND4B

191

O75064
NFWCGITPKGFYKRT

COLGALT2

201

Q8IYK4
SKGCKVYFGRWLIEG

GYS1

96

P13807
LSWGKGQKDLLTPCY

HEXB

296

P07686
LGTCQTKPGQYWKEE

C9orf57

56

Q5W0N0
PKCSAKLGSFNWYGE

DUSP12

291

Q9UNI6
VGCNWLELPAGKYAL

POLD1

261

P28340
SIRGKKWYSSPLLFC

PGBD3

476

Q8N328
VPSGCKEGWNFYSNK

MRC1

941

P22897
PDTCRASIKGYQWLK

KCNAB3

301

O43448
ANTAGVGKWCKPYKF

FNDC8

261

Q8TC99
CARKYLLGVQPAWGS

PMPCA

266

Q10713
PCDRDYKKFWAGLQG

STAP2

31

Q9UGK3
VGYCQGAVWNKPTAK

PSAPL1

46

Q6NUJ1
WGRGCALKDKPGVYT

PLAU

396

P00749
ECPQYIRKKGADVWF

S100A8

41

P05109
WGKTYSIGFLRFCKQ

TMEM184B

161

Q9Y519
CNWDAKKGEYVFPAK

MOV10

596

Q9HCE1
FSCVGLNHKPKGKWY

ING1

381

Q9UK53
CDYFWADKKDPQGNG

GAS7

201

O60861
KLYSEFLGKRPWFAG

GSTM1

136

P09488
KFKNTCWIPGYSAGV

SIN3B

441

O75182
AVELCKNVKLYGFWP

ST8SIA6

331

P61647
SKCAWGKAGVDYAPN

TNS3

791

Q68CZ2
FKLGDDCRQKSYWGA

PI4KAP2

316

A4QPH2
KKSGFSPVRYGQCWV

TGM3

261

Q08188
PCGKYYTLNGSKLWI

ACADVL

236

P49748
SYYRKGGCAMLPVKW

ALK

1281

Q9UM73
NYWLGKKKPCITYGL

CNDP2

196

Q96KP4
GPLEHGQQWKKFLYC

C11orf97

41

A0A1B0GVM6
SNLKCLGLLEPYFWK

RNF17

1216

Q9BXT8
LGLLEPYFWKKGEAC

RNF17

1221

Q9BXT8
PYFWKKGEACAVRGS

RNF17

1226

Q9BXT8
WVKAGYKEPGIARCS

SLIT3

871

O75094
CEAEPKGKLWVNGYA

TNFAIP8L3

16

Q5GJ75
NPDRDSKPWCYVFKA

PLAT

181

P00750
KPYRCPECGKGFSWN

ZSCAN2

556

Q7Z7L9
ELKQWYKGFLKDCPS

VSNL1

26

P62760
AKWYPGCKYLLEQKG

XIAP

321

P98170
AERGYSWYKGQPKTC

ZCCHC3

321

Q9NUD5
NGKWFDKRCRDQLPY

CLEC3B

181

P05452
YRVLEKCQDGWFKGA

SH3RF3

491

Q8TEJ3
LQPFKGWALYCAGKA

SPR

161

P35270
RVYTGEKPYKCNEWG

ZNF137P

36

P52743
EKPYKCNEWGKALSG

ZNF137P

41

P52743
YWGCAIGKARQAAKT

PSMA3

161

P25788
GDYWKKIPGSVSCFT

TECPR2

1346

O15040
YAFLKGSCKWIRTPA

TMEM97

86

Q5BJF2
FGDKFKRPIGSWECS

NUP153

786

P49790
GCAWKNRPGVYTKVY

PRSS3

276

P35030
CSYFARDLWPKQGKK

ZNF492

46

Q9P255
CKLCGKAFFWPSLFR

ZNF442

211

Q9H7R0
QGIKPYRCSWCGKSF

ZNF75D

416

P51815
KDRRGCGKGKWYKFN

USP24

1976

Q9UPU5
WFDASRKGLYLCVGN

TSPEAR

286

Q8WU66
ARRYGPWFKGKDGNE

WSCD2

86

Q2TBF2
YEWEPFAEVKGNRKC

THSD4

331

Q6ZMP0
WRKICPIFKGIGYAI

SLC6A4

151

P31645
ASYDAWKKCLPIRGI

UBR4

4066

Q5T4S7
LKGVDLLRSWCYKGF

TTLL4

1061

Q14679
SWLYTFREKFPGKLC

TRIM62

436

Q9BVG3
VVYLNPKGDGKWCKF

USP7

466

Q93009
NYQWVKFDVCKPGDG

TBRG1

316

Q3YBR2
YRQGCASKLPVKWLA

TYRO3

686

Q06418
FCNSYSKDRGPWIVK

TTLL5

166

Q6EMB2
GSYFKVGERWYKPGC

ZAN

1486

Q9Y493
CWGDSVKLRYGNKPE

AGL

486

P35573