Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnicotinic acid receptor activity

HCAR2 HCAR3

3.01e-0521102GO:0070553
GeneOntologyMolecularFunctionmicrotubule binding

CENPE CENPF LRRK2 KIF16B PRC1 LRPPRC CCDC66 HOOK2

3.07e-043081108GO:0008017
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2 LTBP1

5.26e-0741063GO:0035583
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2 LTBP1

7.25e-0681063GO:0071694
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2 LTBP1

2.11e-05111063GO:0035581
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2 LTBP1

3.63e-05131063GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2 LTBP1

3.63e-05131063GO:1900116
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 LTBP1

3.69e-05131083GO:0001527
GeneOntologyCellularComponentsperm cytoplasmic droplet

ROPN1B ROPN1

2.62e-0451082GO:0097598
DomainTB

FBN1 FBN2 LTBP1

6.47e-0671083PF00683
DomainKRAB

ZNF311 ZNF267 ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF506 ZNF681

7.23e-0635810811PS50805
Domain-

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

8.35e-06679108153.30.160.60
DomainKRAB

ZNF311 ZNF267 ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF506 ZNF681

9.61e-0636910811SM00349
DomainKRAB

ZNF311 ZNF267 ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF506 ZNF681

9.85e-0637010811IPR001909
Domain-

FBN1 FBN2 LTBP1

1.03e-05810833.90.290.10
DomainZnf_C2H2/integrase_DNA-bd

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

1.08e-0569410815IPR013087
Domainzf-C2H2_6

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF676 ZNF846 ZNF506 ZNF107 ZNF681

1.41e-0531410810PF13912
DomaincEGF

LRP1B FBN1 FBN2 LTBP1

1.43e-05261084IPR026823
DomaincEGF

LRP1B FBN1 FBN2 LTBP1

1.43e-05261084PF12662
DomainZnf_C2H2

ZNF311 ZNF267 MECOM ZNF699 ZNF626 TRIM23 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

1.52e-0580510816IPR007087
DomainTB

FBN1 FBN2 LTBP1

1.54e-0591083PS51364
DomainTB_dom

FBN1 FBN2 LTBP1

1.54e-0591083IPR017878
DomainEGF_Ca-bd_CS

COMP LRP1B F7 FBN1 FBN2 LTBP1

2.10e-05971086IPR018097
DomainEGF_CA

COMP LRP1B F7 FBN1 FBN2 LTBP1

2.36e-05991086PS01187
DomainHCAR2/3_rcpt

HCAR2 HCAR3

3.31e-0521082IPR028017
DomainZINC_FINGER_C2H2_2

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

3.92e-0577510815PS50157
DomainZINC_FINGER_C2H2_1

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

4.03e-0577710815PS00028
DomainKRAB

ZNF311 ZNF267 ZNF699 ZNF626 ZNF2 ZNF7 ZNF257 ZNF846 ZNF506 ZNF681

4.33e-0535810810PF01352
Domainzf-C2H2

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF681

4.57e-0569310814PF00096
DomainZnf_C2H2-like

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

5.31e-0579610815IPR015880
DomainZnF_C2H2

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF654 ZNF681

6.29e-0580810815SM00355
DomainRING

ZMYND11 LNX2 TRIM42 DEF8 XIAP TRIM23 SCAF11 LONRF3 RNF145

6.98e-053051089SM00184
DomainEGF_CA

COMP LRP1B F7 FBN1 FBN2 LTBP1

7.63e-051221086SM00179
DomainEGF-like_Ca-bd_dom

COMP LRP1B F7 FBN1 FBN2 LTBP1

8.35e-051241086IPR001881
DomainVps51

EXOC8 COG1

9.90e-0531082IPR014812
DomainFBN

FBN1 FBN2

9.90e-0531082IPR011398
DomainZnf_RING

ZMYND11 LNX2 TRIM42 DEF8 XIAP TRIM23 SCAF11 LONRF3 RNF145

1.16e-043261089IPR001841
DomainEGF_CA

COMP LRP1B FBN1 FBN2 LTBP1

1.41e-04861085PF07645
DomainVPS13_C

VPS13C VPS13B

1.97e-0441082PF16909
DomainSHR-BD

VPS13C VPS13B

1.97e-0441082IPR009543
DomainVPS13_C

VPS13C VPS13B

1.97e-0441082IPR031645
DomainSHR-BD

VPS13C VPS13B

1.97e-0441082PF06650
Domainzf-MYND

ZMYND11 SMYD1 TDRD1

2.32e-04211083PF01753
DomainZnf_MYND

ZMYND11 SMYD1 TDRD1

2.67e-04221083IPR002893
DomainZF_MYND_1

ZMYND11 SMYD1 TDRD1

2.67e-04221083PS01360
DomainZF_MYND_2

ZMYND11 SMYD1 TDRD1

2.67e-04221083PS50865
DomainASX_HYDROXYL

LRP1B F7 FBN1 FBN2 LTBP1

2.87e-041001085PS00010
DomainGrowth_fac_rcpt_

COMP LAMB1 LRP1B FBN1 FBN2 LTBP1

2.93e-041561086IPR009030
DomainATG_C

VPS13C VPS13B

3.28e-0451082PF09333
DomainAutophagy-rel_C

VPS13C VPS13B

3.28e-0451082IPR015412
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1B F7 FBN1 FBN2 LTBP1

3.76e-041061085IPR000152
DomainEGF

COMP LAMB1 LRP1B F7 FBN1 FBN2 LTBP1

4.33e-042351087SM00181
DomainEGF-like_dom

COMP LAMB1 LRP1B F7 FBN1 FBN2 LTBP1

6.12e-042491087IPR000742
DomainEGF_1

COMP LAMB1 LRP1B F7 FBN1 FBN2 LTBP1

7.04e-042551087PS00022
DomainEGF-like_CS

COMP LAMB1 LRP1B F7 FBN1 FBN2 LTBP1

8.07e-042611087IPR013032
DomainEGF_2

COMP LAMB1 LRP1B F7 FBN1 FBN2 LTBP1

8.82e-042651087PS01186
DomainVPS13_N

VPS13C VPS13B

9.07e-0481082IPR026854
DomainChorein_N

VPS13C VPS13B

9.07e-0481082PF12624
Domain-

CNOT10 SRP72 TOMM70 LRPPRC IFT122 LONRF3

1.29e-0320710861.25.40.10
DomainZnf_RING/FYVE/PHD

ZMYND11 LNX2 TRIM42 XIAP TRIM23 PHF3 SCAF11 LONRF3 RNF145

1.38e-034591089IPR013083
Domain-

GCC2 GOLGA4

1.45e-031010821.10.220.60
DomainZF_RING_1

LNX2 TRIM42 XIAP TRIM23 SCAF11 LONRF3 RNF145

1.51e-032911087PS00518
DomainZF_RING_2

LNX2 TRIM42 XIAP TRIM23 SCAF11 LONRF3 RNF145

1.73e-032981087PS50089
DomainGrip

GCC2 GOLGA4

1.76e-03111082SM00755
DomainGRIP

GCC2 GOLGA4

1.76e-03111082PF01465
DomainGRIP_dom

GCC2 GOLGA4

2.11e-03121082IPR000237
DomainGRIP

GCC2 GOLGA4

2.11e-03121082PS50913
DomainTPR-like_helical_dom

CNOT10 SRP72 TOMM70 LRPPRC IFT122 LONRF3

2.35e-032331086IPR011990
DomainEGF_3

COMP LRP1B F7 FBN1 FBN2 LTBP1

2.45e-032351086PS50026
DomainZnf_RING_CS

LNX2 TRIM42 TRIM23 SCAF11 LONRF3

2.58e-031631085IPR017907
DomaincAMP_dep_PK_reg_su_I/II_a/b

ROPN1B ROPN1

3.31e-03151082IPR003117
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF311 ZNF267 ZNF699 ZNF626 ZNF7 ZNF257 ZNF107 ZNF681

1.20e-07181110837372979
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2 LTBP1

1.23e-074110312429738
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2 LTBP1

3.06e-075110334411563
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

PPP1R3B ANKRD26 PSMD1 SRP72 TOMM70 LRPPRC SYNE2 HOOK2 LONRF3 UTRN SNX5

5.43e-074971101123414517
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF626 ZNF506 ZNF107 ZNF681

2.12e-0629110414563677
Pubmed

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

FBN1 FBN2 LTBP1

2.55e-069110338844137
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

GFRAL RB1 CENPE CENPF DOCK11 VPS13C MUC19 SLFN5 CHML BTD TBR1 UTRN

3.91e-067361101229676528
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

9.91e-062110212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

9.91e-062110221851253
Pubmed

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization.

HCAR2 HCAR3

9.91e-062110228186140
Pubmed

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation.

HCAR2 HCAR3

9.91e-062110230154797
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

9.91e-062110230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

9.91e-062110221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

9.91e-062110215131124
Pubmed

FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.

FAN1 HTT

9.91e-062110230358836
Pubmed

The role of HCA2 (GPR109A) in regulating macrophage function.

HCAR2 HCAR3

9.91e-062110223882124
Pubmed

Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

HCAR2 HCAR3

9.91e-062110236891315
Pubmed

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a.

HCAR2 HCAR3

9.91e-062110238007572
Pubmed

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate's protective effect in EAE.

HCAR2 HCAR3

9.91e-062110224691444
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

9.91e-062110220404337
Pubmed

Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.

HCAR2 HCAR3

9.91e-062110231347703
Pubmed

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

FBN1 LTBP1

9.91e-062110228669633
Pubmed

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis.

HCAR2 HCAR3

9.91e-062110230659164
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

9.91e-06211028791520
Pubmed

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium.

HCAR2 HCAR3

9.91e-062110219223991
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

9.91e-06211028307578
Pubmed

Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.

HCAR2 HCAR3

9.91e-062110223967184
Pubmed

Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice.

HCAR2 HCAR3

9.91e-062110226371038
Pubmed

Alloreactive T cells deficient of the short-chain fatty acid receptor GPR109A induce less graft-versus-host disease.

HCAR2 HCAR3

9.91e-062110234653248
Pubmed

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G).

HCAR2 HCAR3

9.91e-062110219136666
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

9.91e-06211027744963
Pubmed

G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion.

HCAR2 HCAR3

9.91e-062110233488584
Pubmed

Lactate-induced activation of HCA2 improves survival in mice with sepsis.

HCAR2 HCAR3

9.91e-062110230951370
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

9.91e-062110226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

9.91e-062110218006876
Pubmed

Interplay between the retinoblastoma protein and LEK1 specifies stem cells toward the cardiac lineage.

RB1 CENPF

9.91e-062110215861132
Pubmed

Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.

HCAR2 HCAR3

9.91e-062110231858105
Pubmed

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.

HCAR2 HCAR3

9.91e-062110232068460
Pubmed

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

HCAR2 HCAR3

9.91e-062110230657794
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

9.91e-062110224833718
Pubmed

Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

HCAR2 HCAR3

9.91e-062110234092246
Pubmed

Molecular identification of high and low affinity receptors for nicotinic acid.

HCAR2 HCAR3

9.91e-062110212522134
Pubmed

G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis.

HCAR2 HCAR3

9.91e-062110230271409
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

9.91e-062110224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

9.91e-062110220529844
Pubmed

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling.

HCAR2 HCAR3

9.91e-062110230596513
Pubmed

The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.

HCAR2 HCAR3

9.91e-062110235320002
Pubmed

GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing.

HCAR2 HCAR3

9.91e-062110216322797
Pubmed

Nicotinic acid receptor agonists.

HCAR2 HCAR3

9.91e-062110218983141
Pubmed

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms.

HCAR2 HCAR3

9.91e-062110231366236
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

9.91e-062110223133647
Pubmed

Mitotic motor CENP-E cooperates with PRC1 in temporal control of central spindle assembly.

CENPE PRC1

9.91e-062110231174204
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

9.91e-06211021852206
Pubmed

GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.

HCAR2 HCAR3

9.91e-062110235489706
Pubmed

Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome.

CENPF HOOK2

9.91e-062110219793914
Pubmed

Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis.

HCAR2 HCAR3

9.91e-062110219561068
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

9.91e-062110212429739
Pubmed

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

HCAR2 HCAR3

9.91e-062110224371223
Pubmed

High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice.

HCAR2 HCAR3

9.91e-062110221774590
Pubmed

Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression.

RB1 CENPF

9.91e-06211027651420
Pubmed

GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.

HCAR2 HCAR3

9.91e-062110236208084
Pubmed

The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells.

HCAR2 HCAR3

9.91e-062110226656756
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

9.91e-062110212524050
Pubmed

Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.

HCAR2 HCAR3

9.91e-062110237597514
Pubmed

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism.

HCAR2 HCAR3

9.91e-062110233924461
Pubmed

Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx.

HCAR2 HCAR3

9.91e-062110233977048
Pubmed

PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily.

HCAR2 HCAR3

9.91e-062110211745392
Pubmed

Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.

HCAR2 HCAR3

9.91e-062110225622782
Pubmed

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice.

HCAR2 HCAR3

9.91e-062110233420329
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

9.91e-06211028120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

9.91e-062110235419902
Pubmed

Molecular identification of nicotinic acid receptor.

HCAR2 HCAR3

9.91e-062110212646212
Pubmed

PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.

HCAR2 HCAR3

9.91e-062110212563315
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

9.91e-062110210504303
Pubmed

Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition.

XIAP EXTL3

9.91e-062110212021770
Pubmed

Deficiency of metabolite sensing receptor HCA2 impairs the salutary effect of niacin in hemorrhagic shock.

HCAR2 HCAR3

9.91e-062110230625381
Pubmed

Ketones and pain: unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain.

HCAR2 HCAR3

9.91e-062110230085883
Pubmed

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation.

HCAR2 HCAR3

9.91e-062110221655214
Pubmed

(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.

HCAR2 HCAR3

9.91e-062110215929991
Pubmed

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

HCAR2 HCAR3

9.91e-062110236991440
Pubmed

Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.

HCAR2 HCAR3

9.91e-062110225320346
Pubmed

CMF1-Rb interaction promotes myogenesis in avian skeletal myoblasts.

RB1 CENPF

9.91e-062110218425850
Pubmed

Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells.

HCAR2 HCAR3

9.91e-062110221441844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

9.91e-062110225524144
Pubmed

Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease.

LRRK2 MUC19

9.91e-062110219714762
Pubmed

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease.

HCAR2 HCAR3

9.91e-062110231914599
Pubmed

CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.

RB1 CENPF

9.91e-06211027542657
Pubmed

Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes.

HCAR2 HCAR3

9.91e-062110220655299
Pubmed

Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization.

CENPE CENPF

9.91e-06211027851898
Pubmed

Evidence for constitutive dimerization of niacin receptor subtypes.

HCAR2 HCAR3

9.91e-062110220380810
Pubmed

GPR109A Expression in the Murine Min6 Pancreatic Beta Cell Line, and Its Relation with Glucose Metabolism and Inflammation.

HCAR2 HCAR3

9.91e-062110226116596
Pubmed

Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function.

HCAR2 HCAR3

9.91e-062110235649469
Pubmed

GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development.

HCAR2 HCAR3

9.91e-062110237595951
Pubmed

The hypophagic response to heat stress is not mediated by GPR109A or peripheral β-OH butyrate.

HCAR2 HCAR3

9.91e-062110226936786
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

9.91e-062110216407178
Pubmed

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response.

HCAR2 HCAR3

9.91e-062110234084164
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

9.91e-062110210359653
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

VPS13C PSMD1 XIAP TMEM255B F7 EVA1C LRPPRC GCC2 SCAF11 IFT122 HOOK2 ZNF107 UTRN VPS13B GOLGA4 HTT

1.84e-0514891101628611215
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

LAMB1 FBN1 FBN2

2.43e-0518110339040056
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

2.97e-053110210825173
InteractionANKRD36B interactions

ZCCHC10 ANKRD36C LRP1B EXOC8 CCDC66 ZNF107

7.71e-07601076int:ANKRD36B
InteractionNTN5 interactions

LRP1B FBN1 FBN2 LTBP1

7.35e-06241074int:NTN5
Cytoband12q12

LRRK2 MUC19 SCAF11

2.01e-0447110312q12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF626 ZNF676 ZNF257 ZNF681

2.20e-041221104chr19p12
CytobandEnsembl 112 genes in cytogenetic band chr12q12

LRRK2 MUC19 SCAF11

4.79e-04631103chr12q12
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF311 ZNF267 MECOM ZNF699 ZNF626 ZNF2 ZNF7 ZNF676 ZNF257 ZNF846 ZNF335 ZNF506 ZNF107 ZNF681

1.07e-06718741428
GeneFamilyHydroxy-carboxylic acid receptors

HCAR2 HCAR3

4.94e-053742200
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TRIM42 CENPE PPP1R3B MARF1 TMEM225

8.77e-04181745694
GeneFamilyRing finger proteins

LNX2 TRIM42 TRIM23 SCAF11 LONRF3 RNF145

9.14e-0427574658
GeneFamilyZinc fingers MYND-type

ZMYND11 SMYD1

3.30e-032174287
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

OMA1 CENPE VPS13C KIF16B ANKHD1 ZNF257 PHF3 GCC2 SYNE2 SCAF11 ZNF107 RNF145 ZNF654 GOLGA4

5.92e-0765610914M18979
CoexpressionBLANCO_MELO_SARS_COV_1_INFECTION_MCR5_CELLS_UP

CENPE CENPF ZNF107

1.50e-05121093M34000
CoexpressionERBB2_UP.V1_DN

CENPE ZNF267 LAMB1 PAK1IP1 ZNF107 GOLGA4 NOL8

1.90e-051971097M2635
CoexpressionGABRIELY_MIR21_TARGETS

PPP1R3B EXOC8 CCNG1 SYNE2 CRYBG1 SCAF11 UTRN GOLGA4

2.88e-052891098M2196
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

LNX2 CENPE CENPF ANKRD26 MECOM ANKHD1 CCDC66 GCC2 SYNE2 GOLGA4

3.62e-0631110610Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#4

CENPE CENPF ANKRD26 CCDC66 COG1 GCC2 SYNE2 SCAF11

5.47e-061921068Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K4
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000

DOCK11 BACH1 LAMB1 SRP72 TRIM23 SYNE2 RNF145 UTRN HTT

9.87e-062751069gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

LNX2 CENPE CENPF PPP1R3B VPS13C ANKRD26 MECOM ZDBF2 CHML ZNF7 CCDC66 KIAA0825 BTD GCC2 SYNE2 NOL8

2.89e-0598310616Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

CENPE CENPF ANKRD26 ZDBF2 SYNE2 GOLGA4 NOL8

5.07e-051921067Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

C9orf85 RB1 CENPE CENPF ANKRD26 ZDBF2 ANKHD1 CCNG1 CCDC66 COG1 BTD SYNE2 GOLGA4 NOL8

6.64e-0583110614Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_k-means-cluster#5_top-relative-expression-ranked_1000

CENPE BACH1 LAMB1 SYNE2 MARF1 RNF145

1.11e-041511066gudmap_developingGonad_P2_ovary_1000_k5
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1

C9orf85 CENPE CENPF ANKRD26 ANKHD1 CCNG1 CCDC66 COG1 BTD GCC2 SYNE2 MARF1 SCAF11

1.37e-0478010613Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_500

CENPE DOCK11 BACH1 ANKRD26 RNF145 UTRN

1.58e-041611066gudmap_developingGonad_e12.5_ovary_k3_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500

CENPE CENPF ANKRD26 CCDC66 COG1 GCC2 SYNE2 SCAF11 LTBP1 UTRN

1.78e-0449210610Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

CENPE DOCK11 BACH1 SRP72 ANKHD1 TRIM23 TAFA2 SYNE2 SCAF11 RNF145 UTRN HTT NOL8

1.89e-0480610613gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#3

LNX2 CENPE ANKRD26 ZNF7 CCDC66 BTD GCC2

2.37e-042461067Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K3
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#3_top-relative-expression-ranked_200

BACH1 SYNE2 RNF145

2.89e-04261063gudmap_developingGonad_e18.5_ovary_200_k3
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

CENPE CENPF DOCK11 VPS13C ANKRD26 ZDBF2 ZNF7 PHF3 SCAF11 NOL8

3.32e-0453210610Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

CENPE ANKRD26 ZDBF2 ZNF7 CCDC66 GCC2

3.44e-041861066Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

LNX2 RB1 CENPE CENPF ANKRD26 MECOM ZDBF2 ANKHD1 CCDC66 COG1 GCC2 SYNE2 GOLGA4 NOL8

4.02e-0498910614Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

CENPE CENPF VPS13C ANKRD26 ZDBF2 ZNF7 CCDC66 KIAA0825 BTD SYNE2 NOL8

4.27e-0465410611Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500_K1

C9orf85 RB1 CENPE CENPF ANKRD26 ZDBF2 TDRD1 ZNF7 CCDC66 GCC2 ZNF846 PLCL2 ZNF506 SCAF11 ZNF654 NOL8

4.27e-04124110616facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000

CENPE BACH1 KIF16B LAMB1 SRP72 TRIM23 SYNE2 MARF1 AIFM3 SCAF11 LONRF3 RNF145

4.61e-0477010612gudmap_developingGonad_P2_ovary_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

C9orf85 LNX2 ZCCHC10 CENPE CENPF ANKRD26 PRC1 ZNF7 CCDC66 GCC2 ZNF846 SYNE2 PLCL2 ZNF506 IFT122 ZNF654

4.71e-04125210616facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

C9orf85 RB1 CENPE CENPF ANKRD26 ZDBF2 CHML ZNF2 ZNF7 CCDC66 PHF3 GCC2 SYNE2 ZNF506 SCAF11 NOL8

4.92e-04125710616facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CENPF VPS13C ANKRD26 PSMD1 XIAP SLFN5 GCC2 SYNE2 SCAF11 UTRN GOLGA4

2.64e-121981101176d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

ZMYND11 VPS13C ANKRD26 XIAP SLFN5 FHAD1 PHF3 GCC2 SYNE2 SCAF11 GOLGA4

2.79e-1219911011fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

SRP72 XIAP CHML LRPPRC GCC2 SCAF11 UTRN VPS13B

2.79e-081931108abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

VPS13C ANKRD26 XIAP SLFN5 FHAD1 GCC2 SYNE2 GOLGA4

3.54e-08199110861b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

ZMYND11 VPS13C SLFN5 PHF3 GCC2 SYNE2 CRYBG1 GOLGA4

3.54e-08199110818a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

VPS13C XIAP SLFN5 PHF3 GCC2 SYNE2 UTRN GOLGA4

3.54e-081991108c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C SLFN5 PHF3 GCC2 SCAF11 UTRN GOLGA4

3.81e-0718411071154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

VPS13C SLFN5 PHF3 SYNE2 SCAF11 UTRN GOLGA4

6.67e-07200110712f1685ce8f218433068e090c9d839cd5a1910bf
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MECOM ZDBF2 TMEM255B AZIN1 FBN1 UTRN

6.10e-061821106c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MECOM ZDBF2 TMEM255B AZIN1 FBN1 UTRN

6.10e-061821106d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COMP LRRK2 KIF16B MECOM LRP1B CTNNA2

7.57e-061891106e059be2965cca70ff5576df055d0af1775b76e00
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD36C TRIM23 CCDC66 PHF3 GCC2 SYNE2

8.03e-061911106696921a4f160b6b55698652488ed781e855e5e51
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C XIAP PHF3 SYNE2 SCAF11 GOLGA4

8.03e-06191110609db184cb90fe282a14474d7217068c58092c6f8
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD36C CCDC66 PHF3 GCC2 SYNE2 CRYBG1

9.04e-061951106ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZDBF2 ANKRD36C GCC2 SYNE2 UTRN GOLGA4

9.58e-06197110657ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC30 RGS22 ANKRD26 FHAD1 KIAA0825 SYNE2

9.58e-06197110674a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

VPS13C BACH1 PHF3 SCAF11 UTRN GOLGA4

9.58e-0619711065c33454b10023decd2f5ccda9229b6512659711e
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

VPS13C SLFN5 PHF3 GCC2 SYNE2 SCAF11

9.86e-0619811064c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK11 BACH1 KIF16B ZNF267 CHML LONRF3

1.01e-0519911065b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD36C PHF3 SYNE2 UTRN VPS13B GOLGA4

1.01e-051991106f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

VPS13C XIAP SLFN5 GCC2 SYNE2 GOLGA4

1.01e-05199110653ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

OMA1 CENPE CENPF PRC1 PAK1IP1 GOLGA4

1.04e-052001106118321ac443feb42aee171baccfc4610f00a8822
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPRY1 DOCK11 TRPC6 LAMB1 FHAD1 FBN2

1.04e-052001106d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SPRY1 DOCK11 TRPC6 LAMB1 FHAD1 FBN2

1.04e-0520011064e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

MECOM AZIN1 FBN1 SYNE2 LTBP1 USP54

1.04e-05200110665b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

ZMYND11 XIAP SLFN5 GCC2 SYNE2

2.39e-051381105817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 LRRK2 LAMB1 FHAD1 FBN2

3.91e-051531105d6526d17826470534b766df144c74e73eb83fdad
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

ANKRD36C SYNE2 ZNF506 CRYBG1 UTRN

5.13e-051621105b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MECOM TMEM255B AZIN1 SYNE2 UTRN

5.76e-0516611057a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MECOM TMEM255B AZIN1 SYNE2 UTRN

5.76e-051661105bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MECOM TMEM255B IFT122 CTNNA2 LONRF3

5.93e-051671105f01b96173deda0239fa482989873cf308e49d48c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPE CENPF SMYD1 PRC1 ZNF626

5.93e-051671105bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MECOM TMEM255B IFT122 CTNNA2 LONRF3

5.93e-0516711055fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COMP CENPE CENPF BTD PLCL2

6.10e-0516811054c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RGS22 FAN1 FHAD1 ROPN1B IFT122

6.10e-0516811059a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCellCTRL-Myeloid-Neutrophil|Myeloid / Disease state, Lineage and Cell class

HCAR2 PPP1R3B LRRK2 HCAR3 SYNE2

6.45e-051701105151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE PPP1R3B PRC1 CMC2 KIAA0825

6.82e-0517211051171e754fd503a0c1152162fcc12a115088a08c7
ToppCellCTRL-Myeloid-Neutrophil|CTRL / Disease state, Lineage and Cell class

HCAR2 PPP1R3B LRRK2 HCAR3 SYNE2

6.82e-051721105ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCell(07)_Ionocytes-(2)_GFP_FOXI1|(07)_Ionocytes / shred by cell type by condition

XIAP GCC2 SCAF11 RNF145 GOLGA4

6.82e-0517211055776b638b845d054f6e884e7df0412477f48517d
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CENPF TNFRSF11A ANKRD36C PRC1 ZNF654

7.01e-05173110520889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CENPF TNFRSF11A ANKRD36C PRC1 ZNF654

7.01e-05173110546e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE CENPF ENTHD1 PRC1 F7

7.20e-05174110565147b0f8c2ccadd5685430d31081520c157536a
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE CENPF TRPC6 LAMB1 PRC1

7.40e-051751105fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE CENPF PRC1 FBN1 USP54

7.40e-051751105a154b28b0b2180652d51d4c7d804b3b81b35899e
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

COMP LAMB1 FBN2 LTBP1 CTNNA2

7.60e-051761105852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

COMP LAMB1 FBN2 LTBP1 CTNNA2

7.60e-051761105d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

ZMYND11 ANKRD26 LRP1B MARF1 USP54

7.81e-051771105e8ab340b20cd41554c3841fe980e078e878af35f
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C SLFN5 SYNE2 SCAF11 UTRN

8.02e-05178110501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CENPE CENPF RGS22 PRC1 TMEM255B

8.02e-051781105c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 LRRK2 TAFA2 SYNE2 USP54

8.23e-051791105fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COMP LAMB1 ZNF2 FBN1 LTBP1

8.67e-051811105b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCellmetastatic_Brain-Fibroblasts-Myofibroblasts|metastatic_Brain / Location, Cell class and cell subclass

COMP LAMB1 FBN1 FBN2 LTBP1

8.67e-051811105bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CENPE CENPF RGS22 PRC1 TMEM255B

8.90e-051821105b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPRY1 LAMB1 MECOM FBN1 LTBP1

8.90e-051821105fbd5e332df73bf7141c822fa67b76367dc962017
ToppCellCiliated_cells-B-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CCDC30 RGS22 DYDC2 FHAD1 SEC14L4

8.90e-051821105e93968f800bfeb258e4e834fc8bf92d1cb72cd73
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPRY1 DOCK11 TRPC6 LAMB1 FBN2

9.13e-0518311058a799807fbf24456a9811e0c64068187940a2f71
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 KIF16B MECOM LRP1B RNF145

9.37e-051841105d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COMP LRRK2 KIF16B MECOM LRP1B

9.37e-0518411058fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

OMA1 ANKRD36C UTRN GOLGA4 HTT

9.37e-051841105ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPE SMYD1 PRC1 F7 LONRF3

9.37e-05184110516aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CENPE CENPF PRC1 F7 LONRF3

9.61e-05185110557c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC30 RGS22 DYDC2 FHAD1 SEC14L4

9.61e-0518511055e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellCiliated_cells-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

CCDC30 RGS22 DYDC2 FHAD1 ROPN1B

9.61e-051851105d77ca57b02125a3a57a37f4aed20c89803b7d551
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

VPS13C RGS22 LRRK2 MUC19 LRP1B

9.86e-05186110523b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CCDC30 PPP1R3B LRRK2 LAMB1 SYNE2

9.86e-051861105f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

KIF16B GCC2 MARF1 SCAF11 VPS13B

9.86e-05186110503db813598b67b1e08f759758a1c2023396921fa
ToppCellCF|World / Disease state, Lineage and Cell class

HCAR2 ZNF267 HCAR3 SYNE2 RNF145

1.01e-041871105eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 TNFRSF11A TMEM255B FBN1 UTRN

1.01e-04187110565d406122dffe18279f14a1ed35ba091730b97be
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MECOM TMEM255B AZIN1 EVA1C UTRN

1.01e-04187110566ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 TNFRSF11A TMEM255B FBN1 UTRN

1.01e-0418711054c15c0ed41a55271fc793cb76fee97fa64190369
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MECOM TMEM255B AZIN1 EVA1C UTRN

1.01e-0418711057170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPRY1 TNFRSF11A TMEM255B FBN1 UTRN

1.01e-0418711055274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell(1)_T_CD4_naive|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SLFN5 ANKRD36C CCDC66 GCC2 SYNE2

1.04e-041881105b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MECOM TMEM255B AZIN1 EVA1C UTRN

1.04e-0418811055bc1537e079c7435196c163bff5f639ea392a33a
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 CCDC30 LRRK2 ZDBF2 LTBP1

1.04e-0418811056468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 CCDC30 LRRK2 ZDBF2 LTBP1

1.04e-0418811057a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 CCDC30 LRRK2 ZDBF2 LTBP1

1.04e-0418811059cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

LNX2 LRRK2 MECOM USP54 RNF145

1.04e-041881105707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCelldroplet-Tongue-nan-24m-Epithelial-basal_cell_of_epidermis|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HCAR2 CENPE CENPF BACH1 PRC1

1.06e-041891105258ef4a52f90236dbed92f325ca033c8fa6156a5
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HCAR2 BACH1 LRRK2 LONRF3 UTRN

1.06e-04189110555aba1ebc012006a5db3ff9c92589cb3d9f7c68a
ToppCellP07-Mesenchymal-developing_mesenchymal_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CENPE CENPF TRPC6 LAMB1 PRC1

1.12e-041911105ddbc5f97f2aef19be4ad93db4139876c939b848e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C XIAP PHF3 SYNE2 SCAF11

1.12e-04191110560c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD36C CCDC66 GCC2 SYNE2 CRYBG1

1.12e-041911105d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-immature_NKT_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPE CENPF PRC1 LONRF3 UNC79

1.12e-041911105c8b99bd3a30c81ee4deba9cbf0196920ab3ab550
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GFRAL COMP LAMB1 FBN1 LTBP1

1.12e-0419111050fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCellP07-Endothelial-large_vessel_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MECOM TMEM255B AZIN1 EVA1C UTRN

1.12e-041911105d162917816dd2e4767c97447c1cddae9397713ab
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

LNX2 LRRK2 MECOM USP54 RNF145

1.12e-041911105e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VPS13C XIAP PHF3 SYNE2 SCAF11

1.12e-041911105973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP MECOM TNFRSF11A SLFN5 TMEM255B

1.14e-041921105945153c41dde6e90d103206955e1707b54eb0665
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PHF3 GCC2 SCAF11 UTRN GOLGA4

1.14e-041921105916fbec1c7ab7969bda711886ac88e877e30c280
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP MECOM TNFRSF11A SLFN5 TMEM255B

1.14e-0419211056ab50579c63f31ca2cd41063a99b129f11c07510
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GFRAL COMP LAMB1 FBN1 LTBP1

1.14e-041921105b9e4585bea280ca0ae159f0c6a2bf7b88a15a6e6
ToppCellCOVID-19-kidney-CD-PC|kidney / Disease (COVID-19 only), tissue and cell type

LAMB1 MECOM ZNF676 PLCL2 CRYBG1

1.17e-041931105738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC30 RGS22 LRRK2 FHAD1 USP54

1.17e-041931105bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

PHF3 GCC2 SCAF11 UTRN GOLGA4

1.17e-041931105e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCelldroplet-Pancreas-Exocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF LAMB1 PRC1 FBN1 FBN2

1.20e-041941105775600880bb77781de48085d8744c1030223de1f
ToppCelldroplet-Pancreas-Exocrine-21m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPF LAMB1 PRC1 FBN1 FBN2

1.20e-04194110504ecb609d233a4b12e275c604810937830363e17
ToppCellCOVID-19-Myeloid-TRAM2|Myeloid / Condition, Lineage and Cell class

SPRY1 HCAR2 LAMB1 CMC2 HCAR3

1.20e-0419411054060a60c0271e7397b07993a1ef47b3291bba6e3
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COMP MECOM TNFRSF11A SLFN5 TMEM255B

1.23e-0419511054db30b3bc65c25626f828cd4f867f20c71809898
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MECOM TMEM255B EVA1C FBN1 UTRN

1.23e-041951105752a100297c26732e12bbbf3ab27a2bd4f5ea06d
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

SLFN5 PHF3 GCC2 SYNE2 UTRN GOLGA4

2.45e-0749596GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_CHROMATIN
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

3.90e-0531072DOID:65 (implicated_via_orthology)
DiseaseCohen syndrome (implicated_via_orthology)

VPS13C VPS13B

3.90e-0531072DOID:0111590 (implicated_via_orthology)
Diseasepneumonia, COVID-19

OMA1 RGS22 LRP1B PLCL2 VPS13B

5.87e-051131075EFO_0003106, MONDO_0100096
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

7.78e-0541072DOID:0060249 (is_implicated_in)
Diseasemean platelet volume

LNX2 DOCK11 LRRK2 KIF16B MECOM PRC1 AZIN1 BTD GCC2 SYNE2 LTBP1 RNF145 HTT

8.38e-05102010713EFO_0004584
DiseasePachygyria

LAMB1 CTNNA2

1.29e-0451072C0266483
DiseaseAgyria

LAMB1 CTNNA2

1.29e-0451072C1879312
DiseaseLissencephaly

LAMB1 CTNNA2

1.94e-0461072C0266463
Diseasecervix uteri carcinoma in situ (is_marker_for)

RB1 XIAP CCNG1

4.80e-04421073DOID:8991 (is_marker_for)
Diseaselower face morphology measurement

LRP1B GCC2 LTBP1 VPS13B

6.79e-041091074EFO_0010948
Diseasecognitive function measurement

CNOT10 ENTHD1 ZDBF2 LRP1B TAFA2 CCNG1 LRPPRC CCDC66 ZNF335 PLCL2 CRYBG1 LTBP1 HOOK2 CTNNA2

6.81e-04143410714EFO_0008354
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE2 HOOK2

8.40e-04121072DOID:11726 (implicated_via_orthology)
Diseasepulse pressure measurement, social deprivation

FBN1 PLCL2

1.15e-03141072EFO_0005763, EFO_0009696
Diseasenausea and vomiting of pregnancy severity measurement

GFRAL TRPC6

1.15e-03141072EFO_0009265
DiseaseAutosomal recessive primary microcephaly

CENPE ZNF335

1.33e-03151072cv:C3711387
Diseasehigh altitude adaptation

HCAR2 EXOC8

1.71e-03171072EFO_0009105
DiseaseMalignant neoplasm of breast

GFRAL RB1 CENPF KIF16B MECOM PRC1 CMC2 SYNE2 USP54 LONRF3 VPS13B

1.81e-03107410711C0006142
DiseaseTourette syndrome, schizophrenia

ENTHD1 PHF3

1.92e-03181072EFO_0004895, MONDO_0005090
Diseasedrug-Induced dyskinesia, response to levodopa

EXTL3 LRPPRC

1.92e-03181072EFO_0010747, EFO_1000904
Diseaseovarian cancer (is_marker_for)

F7 CCNG1 UTRN

1.96e-03681073DOID:2394 (is_marker_for)
Diseasebody weight

HCAR2 VPS13C MECOM IL17RC LRP1B TAFA2 FBN2 PHF3 BTD LTBP1 CTNNA2 UNC79

2.07e-03126110712EFO_0004338
DiseaseChronic myeloproliferative disorder

CENPE CENPF

2.14e-03191072C1292778
Diseaseglomerulonephritis (biomarker_via_orthology)

FBN1 LTBP1

2.37e-03201072DOID:2921 (biomarker_via_orthology)
DiseaseTesticular Germ Cell Tumor

CENPE ZNF257 AIFM3

2.40e-03731073EFO_1000566
Diseasegastric ulcer

MECOM PLCL2

2.62e-03211072EFO_0009454
DiseaseDisproportionate short stature

COMP FBN1 IFT122

2.79e-03771073C0878659
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

HCAR2 HCAR3 ZNF335 SYNE2 HTT

2.80e-032641075EFO_0008317, EFO_0020944
DiseaseSeckel syndrome

CENPE CENPF

2.87e-03221072C0265202
DiseaseSplenomegaly

MECOM XIAP

2.87e-03221072C0038002
DiseaseC-peptide measurement

LRRK2 MUC19

2.87e-03221072EFO_0005187
Diseasefrailty measurement

LRPPRC HTT

3.14e-03231072EFO_0009885
Diseaseobsolete_red blood cell distribution width

HCAR2 BACH1 MECOM PRC1 HCAR3 FBN2 COG1 SYNE2 PLCL2 CRYBG1 HOOK2 SEC14L4

3.55e-03134710712EFO_0005192
Diseasetrauma exposure measurement

RB1 DEF8 LRP1B LTBP1

3.61e-031721074EFO_0010703

Protein segments in the cluster

PeptideGeneStartEntry
NCCCTELQKQVEKHE

TDRD1

1141

Q9BXT4
VCKCVEFLSVHNIEE

BACH1

106

O14867
NCRHLLECAKELDVQ

AZIN1

176

O14977
DCVEAAVCHVKDLEN

AIFM3

66

Q96NN9
AKANKQVCTDINECE

COMP

171

P49747
QLEALQRHCEIICAK

BTBD11

1006

A6QL63
VQCQEEKCATILLEH

ANKRD26

121

Q9UPS8
EEQEILECLKCEHDK

KIF16B

856

Q96L93
CLRHKVQCFVVDKES

CHML

401

P26374
VLCKEHECNIDEVKN

RB1

276

P06400
LQEIHTIQECKECDQ

MECOM

256

Q03112
KCVELTEGIECLQKH

CCNG1

216

P51959
LCKRLTELKDNHCEQ

ANKRD36C

1241

Q5JPF3
CKAGLKQEHCQDVHL

ENTHD1

201

Q8IYW4
IKKFECNLLVVCANH

IFT122

431

Q9HBG6
ELKCPVQNKHKCEEN

LRP1B

2671

Q9NZR2
DERNCHINECLSKKV

LRP1B

2921

Q9NZR2
KHCIKEIQSEINKQC

KIAA0825

46

Q8IV33
IQQNCEKCHKELTSE

DYDC2

81

Q96IM9
KRCKETIQSHKEQCT

GOLGA4

296

Q13439
LQDHFLEIDKKNCCV

HCAR2

6

Q8TDS4
CAISCEKKQDHIQRI

HOOK2

121

Q96ED9
KDLTQCVTCQEKHIT

LNX2

456

Q8N448
RKCVDIDECTQVQHL

LTBP1

911

Q14766
CLHQDVIKLACADIT

OR51B4

176

Q9Y5P0
GKLIHIDDNKCVCRD

MUC19

1146

Q7Z5P9
SQKCCISVHLEHLEK

LRRK2

1001

Q5S007
IVSHLQEDKKCFICN

LAMB1

66

P07942
CCRHDKVEDALNLKE

LRPPRC

721

P42704
ENCELSDHCIKLQKR

NOL8

416

Q76FK4
STAAECVKVAKEHCQ

EXOC8

516

Q8IYI6
CVKVAKEHCQQLGDI

EXOC8

521

Q8IYI6
KTVCEDQELKLHCHE

EVA1C

166

P58658
SCCSHDLKKEVDLLQ

FHAD1

576

B1AJZ9
KKDRVNHCLTICENI

HTT

96

P42858
EKCNKRFLVNCHDLT

DOCK11

361

Q5JSL3
ACIKHIVDCIRAELQ

COG1

576

Q8WTW3
CHQLNICSKVKAEVQ

CTNNA2

786

P26232
EVCHLEAELKNIKQC

CENPF

501

P49454
SECLHCIQVAEAEVK

CENPF

1996

P49454
KCHEDENCISTLSKQ

GFRAL

251

Q6UXV0
RSCKDLDECATKQHN

FBN1

2481

P35555
TEECNVLINLLKECH

CMC2

11

Q9NRP2
NELCEVKHVLDLCRI

EXTL3

71

O43909
LCCANDEEEKKHVSF

DEFB128

51

Q7Z7B8
KCLQEESVVQCEELK

GCC2

816

Q8IWJ2
CKQCIDKDCLHIQKE

CCDC66

96

A2RUB6
AHKVCLTDTCISEKQ

CCDC30

366

Q5VVM6
CEKDAQEVHCDEATK

BTD

371

P43251
ICVCDISKENKEVIQ

MARF1

391

Q9Y4F3
TLFAKHIKLDCERCQ

DEF8

431

Q6ZN54
CTDLKVSENHKGCVL

CRYBG1

491

Q9Y4K1
KDLDECQTKQHNCQF

FBN2

2531

P35556
CLKSCNEQIEESEKH

SCAF11

446

Q99590
KVCELLLHECELQTQ

SEC14L4

126

Q9UDX3
INAKLHDGVCQRCKE

C9orf85

36

Q96MD7
EEELKVAHCCLKEQE

CENPE

1476

Q02224
VAHCCLKEQEETINE

CENPE

1481

Q02224
QKETDCDLCLRVAVH

IL17RC

146

Q8NAC3
CLKKNHEEEVSVLRC

KRT36

226

O76013
DHVCLENCVLKDKAI

PPP1R3B

131

Q86XI6
QECIKEVVEKREACH

FAN1

286

Q9Y2M0
VVALHRCCNKNKIEE

TAFA2

46

Q8N3H0
AETAKHQAKCNICKE

UTRN

3061

P46939
KTLKIVCEVLSCDHN

ROPN1B

136

Q9BZX4
CEKCLRQLQKHAEVT

TRIM42

166

Q8IWZ5
SEVLAQRDCEKNCAK

TBR1

656

Q16650
IQNTCNEVEHKIKFC

SYNE2

2931

Q8WXH0
EVTCHSLDGKCQLKV

TMEM255B

141

Q8WV15
DLCHSHCDESVIQKK

RGS22

1061

Q8NE09
CETHKDDQLICVNEN

F7

141

P08709
LQDHFLEIDKKNCCV

HCAR3

6

P49019
ILCLENHCSIKQQKV

PLCL2

516

Q9UPR0
VCQKELNTLCSELHV

PRC1

71

O43663
HEVVKLCRECLEKQE

SMYD1

326

Q8NB12
IAKCIDHYTKQCVEN

PSMD1

101

Q99460
NKDDVTALHCKVVCL

SRP72

41

O76094
LAVKEVLCHLIECNK

OMA1

261

Q96E52
CHQCVETIVKAKDQQ

ANKHD1

1406

Q8IWZ3
CLQHLACLQDINKDD

CNOT10

46

Q9H9A5
NLQLRKGCKHVDECT

ZNF107

41

Q9UII5
ILTKERHQECSDCGK

ZNF2

166

Q9BSG1
LKISCTNVDECNVHK

ZNF676

81

Q8N7Q3
TRQNKTHTQEKLCEC

ZNF846

186

Q147U1
GHLVTCKQCAEAVDK

XIAP

466

P98170
KTLKIVCEVLSCDHN

ROPN1

136

Q9HAT0
KCVEVCTQSLKHIQH

ZNF267

271

Q14586
KKDHNDLENKNCEVC

ZDBF2

1436

Q9HCK1
CNAEALEAHLAQKKC

ZNF654

1101

Q8IZM8
NVEEKLCSAEKNSCV

PHF3

1696

Q92576
KEDLTQHKFICEQCG

SPRY1

171

O43609
DNKKECLEDVTAVCI

TOMM70

201

O94826
FVCDQKCNIADIKIH

VPS13C

1611

Q709C8
VKLAEAHQQECCQKF

SNX5

336

Q9Y5X3
VCLCEFKAHENRVKD

PAK1IP1

236

Q9NWT1
SEANKQHVRCQKCLE

ZCCHC10

36

Q8TBK6
CEHDNLQLKKGCISV

ZNF626

106

Q68DY1
CLNIHKSDNECKESE

TMEM225

171

Q6GV28
KDTCHELDELQLCKN

ZMYND11

246

Q15326
CLHVDLESLEIKCSN

VPS13B

1206

Q7Z7G8
CEHENLQLSKSVDEC

ZNF681

106

Q96N22
KMLEECHSLNVNCVD

TRPC6

116

Q9Y210
LKRNTEVKSCECHEC

ZNF699

186

Q32M78
HCEKTLQQDDCRVVL

TRIM23

341

P36406
TKEQLEKHNDICAIC

RNF145

526

Q96MT1
CEFVCEDKKALLNHQ

ZNF335

626

Q9H4Z2
VHDETCQVIGCEKEK

SLFN5

231

Q08AF3
VCIHKNSECLKEQQK

SLFN5

361

Q08AF3
CRHDNLQLKKGCESV

ZNF506

106

Q5JVG8
KVNTIKKLHQCEDCE

ZNF7

626

P17097
NEEDKCLLHKVCDTG

TNFRSF11A

81

Q9Y6Q6
QCNKVLIAQKLHECA

ZNF311

236

Q5JNZ3
KEDICTAQHCISHQK

USP54

141

Q70EL1
EISAICQKKNCSSHV

UNC79

366

Q9P2D8
SHTCQKDEKAIECNL

UNC79

846

Q9P2D8
CEHENLQLRKGCKSV

ZNF257

106

Q9Y2Q1
CQEKKRKHCQIESQE

LONRF3

416

Q496Y0