Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of epithelial cell proliferation	REG3G DICER1 ITPR1 YAP1 RPTOR REG3A FOXP1 IRS2 NOTCH2	1.16e-05	270	107	9	GO:0050679
GeneOntologyBiologicalProcess	regulation of epithelial cell differentiation	VEZF1 REG3G FOXA3 DICER1 YAP1 RPTOR REG3A FOXP1	1.76e-05	217	107	8	GO:0030856
GeneOntologyBiologicalProcess	negative regulation of macroautophagy	LRRK2 EHMT2 LZTS1 LYPLA1	3.17e-05	35	107	4	GO:0016242
GeneOntologyBiologicalProcess	cellular response to starvation	LRRK2 FOXA3 PIK3R4 IGF1R EHMT2 RPTOR DEPDC5	5.11e-05	185	107	7	GO:0009267
GeneOntologyBiologicalProcess	detection of monosaccharide stimulus	REG3G REG3A	7.97e-05	3	107	2	GO:0034287
GeneOntologyBiologicalProcess	detection of hexose stimulus	REG3G REG3A	7.97e-05	3	107	2	GO:0009732
GeneOntologyBiologicalProcess	detection of carbohydrate stimulus	REG3G REG3A	7.97e-05	3	107	2	GO:0009730
GeneOntologyBiologicalProcess	positive regulation of detection of glucose	REG3G REG3A	7.97e-05	3	107	2	GO:2000972
GeneOntologyBiologicalProcess	regulation of detection of glucose	REG3G REG3A	7.97e-05	3	107	2	GO:2000970
GeneOntologyBiologicalProcess	detection of glucose	REG3G REG3A	7.97e-05	3	107	2	GO:0051594
GeneOntologyBiologicalProcess	positive regulation of keratinocyte proliferation	REG3G REG3A NOTCH2	1.05e-04	18	107	3	GO:0010838
GeneOntologyBiologicalProcess	negative regulation of organelle assembly	LRRK2 EHMT2 YAP1 CEP97	1.53e-04	52	107	4	GO:1902116
GeneOntologyBiologicalProcess	positive regulation of phosphate metabolic process	IL24 HNF1A LRRK2 DAB1 REG3G ITGA1 STK4 IGF1R RPTOR ETAA1 REG3A GREM1 MMD2 NOTCH2	1.80e-04	879	107	14	GO:0045937
GeneOntologyBiologicalProcess	positive regulation of phosphorus metabolic process	IL24 HNF1A LRRK2 DAB1 REG3G ITGA1 STK4 IGF1R RPTOR ETAA1 REG3A GREM1 MMD2 NOTCH2	1.80e-04	879	107	14	GO:0010562
GeneOntologyBiologicalProcess	response to starvation	LRRK2 FOXA3 PIK3R4 IGF1R EHMT2 RPTOR DEPDC5	1.93e-04	229	107	7	GO:0042594
GeneOntologyBiologicalProcess	positive regulation of phosphorylation	IL24 HNF1A LRRK2 DAB1 REG3G STK4 IGF1R RPTOR ETAA1 REG3A GREM1 MMD2 NOTCH2	2.00e-04	780	107	13	GO:0042327
GeneOntologyBiologicalProcess	regulation of keratinocyte proliferation	REG3G YAP1 REG3A NOTCH2	2.04e-04	56	107	4	GO:0010837
GeneOntologyBiologicalProcess	cell differentiation involved in kidney development	TSHZ3 YAP1 GREM1 NOTCH2	2.19e-04	57	107	4	GO:0061005
GeneOntologyBiologicalProcess	negative regulation of autophagy	LRRK2 EHMT2 LZTS1 RPTOR LYPLA1	2.95e-04	112	107	5	GO:0010507
GeneOntologyBiologicalProcess	regulation of epithelial cell proliferation	REG3G DICER1 ITPR1 STK4 YAP1 RPTOR REG3A FOXP1 IRS2 NOTCH2	3.43e-04	514	107	10	GO:0050678
GeneOntologyBiologicalProcess	positive regulation of protein modification process	IL24 HNF1A LRRK2 DAB1 REG3G ITGA1 STK4 RPTOR ETAA1 TOLLIP REG3A GREM1 MMD2 NOTCH2	3.45e-04	937	107	14	GO:0031401
GeneOntologyBiologicalProcess	positive regulation of protein phosphorylation	IL24 HNF1A LRRK2 DAB1 REG3G STK4 RPTOR ETAA1 REG3A GREM1 MMD2 NOTCH2	3.75e-04	724	107	12	GO:0001934
GeneOntologyBiologicalProcess	regulation of kidney size	HNF1A LRRK2	3.95e-04	6	107	2	GO:0035564
GeneOntologyBiologicalProcess	sexual reproduction	NPHP1 ADAMTS2 LRRK2 FOXA3 DICER1 ITPR1 TDRD7 KMT2C IGF1R EHMT2 NCAPD2 XRN1 KLF17 OSBP2 C2CD6 BOLL CCDC33	4.10e-04	1312	107	17	GO:0019953
GeneOntologyBiologicalProcess	cell morphogenesis	BCL9L LRRK2 DAB1 LAMA2 ITGA1 DICER1 ITPR1 STK4 IGF1R LZTS1 YAP1 NBEAL2 FOXP1 GREM1 RIMS2 NOTCH2	4.28e-04	1194	107	16	GO:0000902
GeneOntologyBiologicalProcess	cellular response to nutrient levels	LRRK2 FOXA3 PIK3R4 IGF1R EHMT2 RPTOR DEPDC5	4.36e-04	262	107	7	GO:0031669
GeneOntologyBiologicalProcess	negative regulation of epithelial cell differentiation	REG3G YAP1 REG3A FOXP1	4.57e-04	69	107	4	GO:0030857
GeneOntologyBiologicalProcess	keratinocyte proliferation	REG3G YAP1 REG3A NOTCH2	4.82e-04	70	107	4	GO:0043616
GeneOntologyBiologicalProcess	lung development	TSHZ3 ADAMTS2 HIKESHI TNRC6C DICER1 YAP1 FOXP1	5.10e-04	269	107	7	GO:0030324
Domain	ARM-type_fold	LRRK2 HEATR1 NCAPG2 ELMO1 ITPR1 PIK3R4 THADA RPTOR NBEAL2 NCAPD2 DAAM1	3.58e-06	339	106	11	IPR016024
Domain	HEAT	HEATR1 NCAPG2 PIK3R4 RPTOR NCAPD2	7.55e-06	48	106	5	PF02985
Domain	HEAT	HEATR1 NCAPG2 PIK3R4 RPTOR NCAPD2	1.93e-05	58	106	5	IPR000357
Domain	ARM-like	LRRK2 HEATR1 NCAPG2 ELMO1 PIK3R4 RPTOR NBEAL2 NCAPD2 DAAM1	2.33e-05	270	106	9	IPR011989
Domain	-	LRRK2 HEATR1 NCAPG2 ELMO1 PIK3R4 RPTOR NCAPD2 DAAM1	3.90e-05	222	106	8	1.25.10.10
Pubmed	Human transcription factor protein interaction networks.	BCL9L HNF1A TSHZ3 VEZF1 TNRC6C MRPL2 MFAP1 KMT2C BRD8 ZFHX4 DCP1B EHMT2 YAP1 PRRC2C XRN1 DLAT FOXP1 ZFHX3 YY1AP1 USP54 SRRM2 MNT	4.46e-10	1429	108	22	35140242
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TSHZ3 GGA2 ADAMTS2 POLA1 KIAA0586 LRRK2 LAMA2 HEATR1 ITPR1 IGF1R PRPF40B EHMT2 NCAPD2 SP5 PWWP3B USP54 RIMS2 MNT CCDC33	6.33e-09	1215	108	19	15146197
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DICER1 MFAP1 THADA BRD8 ZFHX4 PRPF40B EHMT2 RPTOR XRN1 DLAT FOXP1 ZFHX3 IRS2 USP54 KAT6B SRRM2 NOTCH2 SON	1.04e-08	1116	108	18	31753913
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ATXN2L NELFCD PIK3R4 STK4 IGF1R DCP1B YAP1 PRRC2C RPTOR XRN1 NAV1 IRS2 USP54 SRRM2 NOTCH2	7.36e-08	861	108	15	36931259
Pubmed	Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.	HNF1A FOXA3 ZFHX3	1.16e-07	4	108	3	33368532
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ATMIN ATXN2L VEZF1 HIKESHI POLA1 REG3G KERA HEATR1 FAM186B NCAPG2 DICER1 KMT2C BRD8 EHMT2 XRN1 DLAT DEPDC5 MNT	1.41e-07	1327	108	18	32694731
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ATMIN GRID1 TNRC6C CDC42BPB KMT2C THADA IGF1R PER2 RPTOR NBEAL2 NCAPD2 NAV1 DEPDC5 IRS2 MBD5 NOTCH2	3.18e-07	1105	108	16	35748872
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ATXN2L CYP19A1 BRD8 DCP1B EHMT2 YAP1 RPTOR NCAPD2 IRS2 SRRM2 SON	5.07e-07	503	108	11	16964243
Pubmed	Defining the membrane proteome of NK cells.	ATXN2L NELFCD HEATR1 ITGA1 NCAPG2 ELMO1 NOMO1 ITPR1 PIK3R4 DCP1B PRRC2C NBEAL2 NCAPD2 XRN1 DAAM1 NOTCH2	6.62e-07	1168	108	16	19946888
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ATMIN NLGN4Y DAB1 TNRC6C CDC42BPB FARP2 PKNOX2 KMT2C THADA IGF1R RPTOR NAV1 FOXP1 ZFHX3 DAAM1 MBD5 KAT6B NOTCH2	7.54e-07	1489	108	18	28611215
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DENND2A GGA2 DICER1 KMT2C RPTOR NBEAL2 NCAPD2 DEPDC5 DAAM1 KAT6B RIMS2	8.31e-07	529	108	11	14621295
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	FARP2 PIK3R4 MFAP1 IGF1R YAP1 IRS2 SRRM2 SON	1.40e-06	255	108	8	15324660
Pubmed	A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.	ADAMTS2 DAB1 ITPR1	2.41e-06	9	108	3	31491533
Pubmed	Maternal hepatocytes heterogeneously and dynamically exhibit developmental phenotypes partially via yes-associated protein 1 during pregnancy.	STK4 YAP1 NOTCH2	2.41e-06	9	108	3	36283963
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	REG3G IGF1R REG3A IRS2	3.80e-06	34	108	4	33505018
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	DAB1 ITPR1 FOXP1 DAAM1 NOTCH2	5.93e-06	82	108	5	31073041
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TSHZ3 NELFCD ZFHX4 EHMT2 XRN1 NAV1 FOXP1 ZFHX3 IRS2	6.58e-06	418	108	9	34709266
Pubmed	Pancreatic islet immunoreactivity to the Reg protein INGAP.	REG3G REG3A	9.55e-06	2	108	2	17998566
Pubmed	Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.	ITPR1 OSBP2	9.55e-06	2	108	2	27588468
Pubmed	Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease.	IGF1R IRS2	9.55e-06	2	108	2	19487308
Pubmed	Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia.	REG3G REG3A	9.55e-06	2	108	2	21187123
Pubmed	ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum calcium release.	ITPR1 OSBP2	9.55e-06	2	108	2	31648575
Pubmed	Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.	REG3G REG3A	9.55e-06	2	108	2	26867181
Pubmed	The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.	ZFHX4 ZFHX3	9.55e-06	2	108	2	10873665
Pubmed	Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP).	REG3G REG3A	9.55e-06	2	108	2	7679928
Pubmed	YAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal.	NUTM1 YAP1	9.55e-06	2	108	2	32436169
Pubmed	Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine.	REG3G REG3A	9.55e-06	2	108	2	32560820
Pubmed	Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer.	REG3G REG3A	9.55e-06	2	108	2	8076648
Pubmed	Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma.	IGF1R YAP1	9.55e-06	2	108	2	32546241
Pubmed	Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.	PER2 ZFHX3	9.55e-06	2	108	2	34632336
Pubmed	The Reg3α (HIP/PAP) Lectin Suppresses Extracellular Oxidative Stress in a Murine Model of Acute Liver Failure.	REG3G REG3A	9.55e-06	2	108	2	25938566
Pubmed	Regulation of pancreatitis-associated protein (HIP/PAP) mRNA levels in mouse pancreas and small intestine.	REG3G REG3A	9.55e-06	2	108	2	8795446
Pubmed	Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.	REG3G REG3A	9.55e-06	2	108	2	21979939
Pubmed	HIP/PAP protects against bleomycin-induced lung injury and inflammation and subsequent fibrosis in mice.	REG3G REG3A	9.55e-06	2	108	2	32352211
Pubmed	The interplay between IGF-1R signaling and Hippo-YAP in breast cancer stem cells.	IGF1R YAP1	9.55e-06	2	108	2	37081542
Pubmed	Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.	STK4 YAP1	9.55e-06	2	108	2	32376130
Pubmed	SON and SRRM2 are essential for nuclear speckle formation.	SRRM2 SON	9.55e-06	2	108	2	33095160
Pubmed	miRNAs are required for generating a time delay critical for the circadian oscillator.	DICER1 PER2	9.55e-06	2	108	2	24094851
Pubmed	Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.	IGF1R IRS2	9.55e-06	2	108	2	10829031
Pubmed	Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome.	REG3G REG3A	9.55e-06	2	108	2	29544958
Pubmed	Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.	REG3G REG3A	9.55e-06	2	108	2	19095652
Pubmed	Symbiotic bacteria direct expression of an intestinal bactericidal lectin.	REG3G REG3A	9.55e-06	2	108	2	16931762
Pubmed	Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.	STK4 YAP1	9.55e-06	2	108	2	24813251
Pubmed	Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota.	REG3G REG3A	9.55e-06	2	108	2	21694778
Pubmed	Recombinant Reg3α protein protects against experimental acute pancreatitis in mice.	REG3G REG3A	9.55e-06	2	108	2	26683606
Pubmed	Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein.	REG3G REG3A	9.55e-06	2	108	2	10564727
Pubmed	Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus.	REG3G REG3A	9.55e-06	2	108	2	21245462
Pubmed	An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.	STK4 YAP1 RPTOR	1.29e-05	15	108	3	28457749
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	BCL9L VEZF1 HEATR1 CDC42BPB DICER1 NOMO1 FARP2 KMT2C BRD8 EHMT2 NCAPD2 XRN1 TOLLIP ZFHX3 DAAM1 SON	1.55e-05	1497	108	16	31527615
Pubmed	High-Confidence Interactome for RNF41 Built on Multiple Orthogonal Assays.	IGF1R XRN1 NAV1 CEP97	1.81e-05	50	108	4	29560723
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	NPHP1 ATXN2L NOMO1 TDRD7 ZC3H10 TOLLIP YY1AP1 USP54 KAT6B CCDC33	2.07e-05	608	108	10	16713569
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	GGA2 TNRC6C FARP2 PIK3R4 STK4 MFAP1 DCP1B YAP1 RPTOR XRN1 TOLLIP IRS2 CEP97	2.08e-05	1038	108	13	26673895
Pubmed	Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis.	BCL9L NAV1 FOXP1 NOTCH2	2.29e-05	53	108	4	24982181
Pubmed	YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration.	REG3G YAP1 REG3A	2.30e-05	18	108	3	29249464
Pubmed	Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction.	REG3G REG3A	2.86e-05	3	108	2	23064197
Pubmed	Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.	IGF1R IRS2	2.86e-05	3	108	2	10417963
Pubmed	Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations.	REG3G PER2	2.86e-05	3	108	2	27912059
Pubmed	Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.	STK4 YAP1	2.86e-05	3	108	2	22042863
Pubmed	HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo.	REG3G REG3A	2.86e-05	3	108	2	10329612
Pubmed	Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.	REG3G REG3A	2.86e-05	3	108	2	33923774
Pubmed	Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.	STK4 YAP1	2.86e-05	3	108	2	24881775
Pubmed	YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.	STK4 YAP1	2.86e-05	3	108	2	25772357
Pubmed	Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.	LAMA2 YAP1	2.86e-05	3	108	2	27435623
Pubmed	Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta.	IGF1R IRS2	2.86e-05	3	108	2	19190347
Pubmed	The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.	DICER1 YAP1	2.86e-05	3	108	2	24324261
Pubmed	Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.	REG3G REG3A	2.86e-05	3	108	2	25751817
Pubmed	Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.	STK4 YAP1	2.86e-05	3	108	2	32332916
Pubmed	A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.	IGF1R IRS2	2.86e-05	3	108	2	21340542
Pubmed	p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.	REG3G REG3A	2.86e-05	3	108	2	14660681
Pubmed	Stiehopus japonieus acidic mucopolysaccharide inhibits the proliferation of pancreatic cancer SW1990 cells through Hippo-YAP pathway.	STK4 YAP1	2.86e-05	3	108	2	28099921
Pubmed	Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution.	IGF1R IRS2	2.86e-05	3	108	2	17898946
Pubmed	Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.	REG3G REG3A	2.86e-05	3	108	2	30106382
Pubmed	THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.	THADA IGF1R	2.86e-05	3	108	2	28193878
Pubmed	The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis Through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway.	EHMT2 YAP1	2.86e-05	3	108	2	31990985
Pubmed	Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma.	NUTM1 YAP1	2.86e-05	3	108	2	31145701
Pubmed	Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.	IGF1R IRS2	2.86e-05	3	108	2	21628386
Pubmed	IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma.	IGF1R IRS2	2.86e-05	3	108	2	24810113
Pubmed	REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.	REG3G REG3A	2.86e-05	3	108	2	34099862
Pubmed	IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice.	REG3G REG3A	2.86e-05	3	108	2	27143303
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN2L MFAP1 BRD8 YAP1 RPTOR YY1AP1 IRS2 KAT6B SRRM2 NOTCH2 SON	3.01e-05	774	108	11	15302935
Pubmed	Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.	HNF1A THADA NOTCH2	3.19e-05	20	108	3	20075150
Pubmed	The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.	ZFHX4 FOXP1 ZFHX3	3.19e-05	20	108	3	35177643
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ATXN2L POLA1 HEATR1 DICER1 PRRC2C NCAPD2 XRN1 DLAT SRRM2 SON	3.78e-05	653	108	10	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ATMIN TNRC6C PER2 PRRC2C NAV1 YY1AP1 SRRM2 SON	4.17e-05	407	108	8	12693553
Pubmed	Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.	HNF1A THADA NOTCH2	4.30e-05	22	108	3	19794065
Pubmed	The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity.	REG3G ITPR1 REG3A	4.30e-05	22	108	3	11696558
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DICER1 ITPR1 STK4 FOXP1 ZFHX3 DAAM1 MBD5 KAT6B NOTCH2	4.65e-05	536	108	9	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DICER1 ITPR1 STK4 FOXP1 ZFHX3 DAAM1 MBD5 KAT6B NOTCH2	4.78e-05	538	108	9	10512203
Pubmed	Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.	REG3G REG3A FOXP1	4.93e-05	23	108	3	28190640
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	HNF1A DICER1 NOMO1 EHMT2 ZFHX3 KLF17 KAT6B NOTCH2	5.56e-05	424	108	8	21731673
Pubmed	TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer.	STK4 YAP1	5.71e-05	4	108	2	30673917
Pubmed	Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.	REG3G REG3A	5.71e-05	4	108	2	23147030
Pubmed	The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.	REG3G REG3A	5.71e-05	4	108	2	22727489
Pubmed	Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.	IGF1R IRS2	5.71e-05	4	108	2	20947509
Pubmed	Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study.	DAB1 KMT2C	5.71e-05	4	108	2	20600896
Pubmed	Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells.	REG3G REG3A	5.71e-05	4	108	2	19343564
Pubmed	Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization.	REG3G REG3A	5.71e-05	4	108	2	23867474
Pubmed	Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.	REG3G REG3A	5.71e-05	4	108	2	22723890
Pubmed	The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function.	REG3G REG3A	5.71e-05	4	108	2	36240758
Pubmed	YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1.	STK4 YAP1	5.71e-05	4	108	2	34466790
Interaction	YWHAG interactions	ATXN2L HNF1A NELFCD LRRK2 FARP2 PIK3R4 STK4 MFAP1 IGF1R DCP1B YAP1 PRRC2C RPTOR NAV1 IRS2 USP54 SRRM2 CEP97 NOTCH2 SON	5.96e-06	1248	105	20	int:YWHAG
Interaction	FOXI1 interactions	HEATR1 KMT2C ZFHX4 YAP1 FOXP1 USP54	8.59e-06	92	105	6	int:FOXI1
Interaction	FOXL1 interactions	NELFCD HEATR1 KMT2C ZFHX4 NCAPD2 FOXP1 ZFHX3 YY1AP1	8.64e-06	196	105	8	int:FOXL1
Interaction	FEV interactions	VEZF1 KMT2C ZFHX4 EHMT2 YAP1 FOXP1 ZFHX3 YY1AP1	1.12e-05	203	105	8	int:FEV
Interaction	CPEB4 interactions	TNRC6C TDRD7 DCP1B PRRC2C RPTOR XRN1 USP54	1.76e-05	156	105	7	int:CPEB4
Interaction	VSX1 interactions	TSHZ3 ZFHX4 EHMT2 FOXP1 ZFHX3	2.42e-05	66	105	5	int:VSX1
Interaction	ZBTB39 interactions	ZBTB39 POLR3E FOXP1 NOTCH2	2.53e-05	33	105	4	int:ZBTB39
Interaction	TEAD1 interactions	TSHZ3 KMT2C ZFHX4 EHMT2 YAP1 FOXP1 ZFHX3	3.81e-05	176	105	7	int:TEAD1
Interaction	LHX2 interactions	BCL9L TSHZ3 KMT2C ZFHX4 EHMT2 FOXP1 ZFHX3	4.88e-05	183	105	7	int:LHX2
Interaction	YWHAH interactions	ATXN2L NELFCD LRRK2 PIK3R4 STK4 DCP1B YAP1 PRRC2C RPTOR XRN1 NAV1 IRS2 GREM1 USP54 RIMS2 SRRM2 NOTCH2	5.30e-05	1102	105	17	int:YWHAH
Interaction	PAX9 interactions	BCL9L KMT2C ZFHX4 EHMT2 FOXP1 ZFHX3	6.13e-05	130	105	6	int:PAX9
Interaction	HNF1B interactions	HNF1A KMT2C ZFHX4 YAP1 FOXP1 ZFHX3 USP54	6.19e-05	190	105	7	int:HNF1B
Interaction	TRIM52 interactions	KIAA0586 NCAPG2 POLR3E YY1AP1 USP54 CEP97	6.95e-05	133	105	6	int:TRIM52
Interaction	GSC interactions	BCL9L KMT2C ZFHX4 FOXP1 ZFHX3	9.18e-05	87	105	5	int:GSC
Interaction	LATS1 interactions	LRRK2 TNRC6C STK4 DCP1B YAP1 DLAT USP54 SRRM2 NOTCH2 MYBPC2	1.01e-04	440	105	10	int:LATS1
Interaction	DPRX interactions	ZFHX4 EHMT2 ZFHX3	1.06e-04	18	105	3	int:DPRX
Interaction	H2BC9 interactions	ADAMTS2 LAMA2 CDC42BPB ADGRG4 MRPL2 ZFHX4 DLAT DEPDC5 MBD5 KAT6B	1.13e-04	446	105	10	int:H2BC9
Interaction	SOX2 interactions	ATXN2L BCL9L TSHZ3 MAB21L4 HEATR1 MRPL2 MFAP1 KMT2C BRD8 ZFHX4 EHMT2 LZTS1 YAP1 NCAPD2 XRN1 TOLLIP FOXP1 ZFHX3 KAT6B	1.26e-04	1422	105	19	int:SOX2
Interaction	TLE3 interactions	BCL9L TSHZ3 VEZF1 FOXA3 BRD8 PRPF40B ZFHX3 SRRM2 SON	1.55e-04	376	105	9	int:TLE3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 ZFHX4 ZFHX3	2.66e-05	15	72	3	529
Coexpression	GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS	TSHZ3 GGA2 SHISA2 ITGA1 NCAPG2 DICER1 ELMO1 ITPR1 PKNOX2 BRD8 LZTS1 XRN1 ETAA1 NAV1 FOXP1 DAAM1 CEP97 NOTCH2	1.17e-07	1009	106	18	M157
Coexpression	GSE7509_UNSTIM_VS_FCGRIIB_STIM_MONOCYTE_DN	SLC4A8 TNRC6C ITPR1 NCAPD2 NAV1 DEPDC5 SON	5.18e-06	166	106	7	M6826
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1	ACSS1 IGF1R PER2 XRN1 IRS2	9.00e-06	69	106	5	M1145
Coexpression	YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1	ACSS1 IGF1R PER2 XRN1 IRS2	1.36e-05	75	106	5	MM868
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_PLASMA_CELL_DAY7_UP	HNF1A LRRK2 ITPR1 TDRD7 REG3A NOTCH2 MYBPC2	1.69e-05	199	106	7	M9366
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	VEZF1 DICER1 ITPR1 TDRD7 PIK3R4 IGF1R YAP1 PRRC2C ZFHX3 DAAM1 KAT6B MNT SON	4.25e-05	856	106	13	M4500
Coexpression	GSE14415_INDUCED_TREG_VS_TCONV_DN	ACSS1 TNRC6C RPTOR FOXP1 MBD5 KAT6B	5.76e-05	165	106	6	M2960
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#1_top-relative-expression-ranked_1000	SHISA2 BRD8 ZFHX4 NCAPD2 DLAT FOXP1 PWWP3B KAT6B	6.13e-06	195	106	8	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k1
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_1000	ATXN2L TSHZ3 ADAMTS2 SHISA2 TNRC6C BRD8 ZFHX4 TRIM17 NCAPD2 DLAT FOXP1 ZFHX3 PWWP3B KAT6B	3.90e-05	791	106	14	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IL24 DENND2A NLGN4Y LAMA2 PKNOX2 LZTS1 ZFHX3 KLF17	4.58e-09	156	108	8	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	DENND2A TSHZ3 ADAMTS2 LAMA2 ITGA1 ELMO1 PKNOX2 TOX2	2.42e-08	193	108	8	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A TSHZ3 ADAMTS2 LAMA2 ITGA1 ELMO1 PKNOX2 TOX2	2.52e-08	194	108	8	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 ZFHX4 PRRC2C XRN1 IRS2 DAAM1 SRRM2 MYBPC2	2.62e-08	195	108	8	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IL24 DENND2A NLGN4Y LAMA2 PKNOX2 LZTS1 KLF17	1.14e-07	157	108	7	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A NLGN4Y LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	3.24e-07	183	108	7	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A NLGN4Y LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	3.36e-07	184	108	7	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 LRRK2 KMT2C PRRC2C NAV1 ZFHX3 IRS2	3.61e-07	186	108	7	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 ZFHX4 PRRC2C XRN1 IRS2 DAAM1 SRRM2	4.32e-07	191	108	7	7d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCell	droplet-Heart-HEART-1m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACSS1 HEATR1 PER2 DCP1B MBD5 RIMS2	6.79e-07	127	108	6	983489a69d3b1f1fe21110a862ac1dba53e9d31c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 SHISA2 ITGA1 PKNOX2 LZTS1	1.47e-06	145	108	6	051d964ff6bdc12ba3f0459d3e6ab16fa9507b0b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 SHISA2 ITGA1 PKNOX2 KLF17	1.80e-06	150	108	6	7a9d6a7ff8000e9a061e1b586e4c258cc91a2a09
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 SHISA2 ITGA1 PKNOX2 KLF17	1.80e-06	150	108	6	e5b843cb2bc847f6cab4cbec0a2a6a72fac50fee
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	DENND2A LAMA2 GRID1 ITGA1 PKNOX2 LZTS1	3.83e-06	171	108	6	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	DENND2A ITGA1 FOXA3 PKNOX2 LZTS1 KLF17	3.96e-06	172	108	6	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VEZF1 CHST14 CDC42BPB PIK3R4 RPTOR MBD5	4.67e-06	177	108	6	946803293a7955116c80f403e99e4093e798ca3f
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS2 LAMA2 SHISA2 ITPR1 PKNOX2 LZTS1	6.21e-06	186	108	6	cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A GRID1 ITGA1 PKNOX2 LZTS1 ZFHX3	6.40e-06	187	108	6	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	DENND2A ADAMTS2 LAMA2 ITGA1 ELMO1 PKNOX2	6.40e-06	187	108	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A LAMA2 GRID1 ITGA1 PKNOX2 LZTS1	6.60e-06	188	108	6	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	DENND2A LAMA2 GRID1 ITGA1 PKNOX2 LZTS1	6.81e-06	189	108	6	d7ed96add29f219183c802895fbff519b627f635
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 GRID1 ITGA1 PKNOX2 LZTS1 ZFHX3	7.23e-06	191	108	6	04c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	STK4 IGF1R PRRC2C FOXP1 IRS2 SON	7.67e-06	193	108	6	4e78ddc96d8e403a21c4a303b1f26512d2ac91e8
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAMTS2 LAMA2 ELMO1 PKNOX2 IRS2 TOX2	7.90e-06	194	108	6	e93de9428c986b8943fc169258847c650cfab0e5
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAMTS2 NLGN4Y LAMA2 ITGA1 ELMO1 PKNOX2	7.90e-06	194	108	6	35f132cc38ac133be01834ed0946188aa0757eb4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 PKNOX2 ZFHX4	8.14e-06	195	108	6	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 PKNOX2 ZFHX4	8.14e-06	195	108	6	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D122\|Adult / Lineage, Cell type, age group and donor	DENND2A ADAMTS2 LAMA2 ITGA1 PKNOX2 TOX2	8.14e-06	195	108	6	aa0add081881d349099d12efca5cdee098038d4e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 LZTS1 ZFHX3	8.38e-06	196	108	6	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ3 ADAMTS2 LAMA2 GRID1 ITGA1 GREM1	8.38e-06	196	108	6	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ3 ADAMTS2 LAMA2 GRID1 ITGA1 GREM1	8.38e-06	196	108	6	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DENND2A GRID1 ITGA1 PKNOX2 LZTS1 ZFHX3	8.38e-06	196	108	6	754a3613340932563cd8424d775e18b93c3a1aaa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 ZFHX4 LZTS1	8.87e-06	198	108	6	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	Fetal_29-31_weeks-Mesenchymal\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A TSHZ3 ADAMTS2 LAMA2 ITGA1 PKNOX2	8.87e-06	198	108	6	21cf4d81386761d09d0f6829c01c198e5524176d
ToppCell	Bronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A GRID1 ITGA1 PKNOX2 LZTS1 KLF17	9.13e-06	199	108	6	929f809579368201331d9099d8904b6e3c41797b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	ZFHX4 YAP1 NAV1 FOXP1 IRS2 NOTCH2	9.13e-06	199	108	6	358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCell	Bronchial-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A GRID1 ITGA1 PKNOX2 LZTS1 KLF17	9.13e-06	199	108	6	854628ce91068093c14bd4d45ba38c41469f3549
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	9.40e-06	200	108	6	b5b5a32925f225610fe25a021a742d6397162863
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	9.40e-06	200	108	6	d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 ITPR1 LZTS1 ZFHX3	9.40e-06	200	108	6	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	9.40e-06	200	108	6	4e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCell	Parenchymal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A ADAMTS2 LAMA2 ITGA1 ELMO1 PKNOX2	9.40e-06	200	108	6	cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	9.40e-06	200	108	6	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 ZFHX3	9.40e-06	200	108	6	cb7ef774b6d300f8019c5b16a04e3ebd165e4f1c
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	DENND2A TSHZ3 LAMA2 ITGA1 LZTS1 ZFHX3	9.40e-06	200	108	6	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A ADAMTS2 LAMA2 ITGA1 ELMO1 PKNOX2	9.40e-06	200	108	6	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1 NOTCH2	9.40e-06	200	108	6	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 POLA1 LAMA2 ITGA1 PKNOX2	5.75e-05	169	108	5	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NLGN4Y LAMA2 GRID1 ZFHX4 NOTCH2	6.60e-05	174	108	5	9c916af5eebd932f67dc9117e1d26ff194a2ff2c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NLGN4Y LAMA2 GRID1 ZFHX4 NOTCH2	6.60e-05	174	108	5	bc71521f44a5fe013af42b06b5d1bd2446ecf3b5
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAB21L4 FOXA3 ADGRG4 NBEAL2 RIMS2	6.96e-05	176	108	5	71f96cace3f20fbef975037f4deff9b82b0282a1
ToppCell	droplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB1 REG3G FOXA3 ZFHX4 CCDC33	7.15e-05	177	108	5	7ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAB1 REG3G FOXA3 ZFHX4 CCDC33	7.15e-05	177	108	5	092a345cb802f183322aa5542341ba2d96d4f06a
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	7.35e-05	178	108	5	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-4\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	GGA2 CHST14 SHISA2 ZC3H10 LZTS1	7.74e-05	180	108	5	886ebaf9cf8992e8dd13fca799a1d1a2a9ce73d8
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 PRRC2C XRN1 FOXP1 SRRM2	8.16e-05	182	108	5	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 PRRC2C XRN1 FOXP1 SRRM2	8.37e-05	183	108	5	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	DENND2A ITGA1 PKNOX2 LZTS1 TOX2	8.37e-05	183	108	5	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK2 PRRC2C XRN1 FOXP1 SRRM2	8.37e-05	183	108	5	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 ITGA1 ADGRG4 PKNOX2	8.59e-05	184	108	5	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1	8.59e-05	184	108	5	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	DENND2A GRID1 ITGA1 LZTS1 ZFHX3	8.59e-05	184	108	5	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DENND2A LAMA2 ITGA1 LZTS1 ZFHX3	8.59e-05	184	108	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	8.81e-05	185	108	5	a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	8.81e-05	185	108	5	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST14 LRRK2 ZBTB39 NAV1 SP5	8.81e-05	185	108	5	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.27e-05	187	108	5	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.27e-05	187	108	5	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.27e-05	187	108	5	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGA2 ACSS1 LRRK2 FOXP1 NOTCH2	9.27e-05	187	108	5	b51af2824e65734f333b1325117f4a2e88b17c23
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GGA2 ACSS1 LRRK2 FOXP1 NOTCH2	9.27e-05	187	108	5	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	9.27e-05	187	108	5	a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRK2 FARP2 TDRD7 XRN1 NOTCH2	9.50e-05	188	108	5	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRK2 FARP2 TDRD7 XRN1 NOTCH2	9.50e-05	188	108	5	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRK2 FARP2 TDRD7 XRN1 NOTCH2	9.50e-05	188	108	5	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	9.50e-05	188	108	5	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GGA2 LRRK2 FARP2 PER2 TOX2	9.99e-05	190	108	5	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.99e-05	190	108	5	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.99e-05	190	108	5	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	LAMA2 ITGA1 STK4 NAV1 TOX2	9.99e-05	190	108	5	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	9.99e-05	190	108	5	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.99e-05	190	108	5	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 NAV1 FOXP1 GREM1 SON	9.99e-05	190	108	5	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ELMO1 ZFHX4 FOXP1 ZFHX3 RIMS2	9.99e-05	190	108	5	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	DENND2A ADAMTS2 LAMA2 ITGA1 PKNOX2	9.99e-05	190	108	5	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A GRID1 ITGA1 PKNOX2 LZTS1	9.99e-05	190	108	5	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	9.99e-05	190	108	5	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DENND2A TSHZ3 ADAMTS2 PKNOX2 TOX2	1.02e-04	191	108	5	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL24 DENND2A TSHZ3 ITGA1 PKNOX2	1.02e-04	191	108	5	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ3 ADAMTS2 ITGA1 ITPR1 PKNOX2	1.02e-04	191	108	5	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1	1.02e-04	191	108	5	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS2 LAMA2 SHISA2 PKNOX2 LZTS1	1.02e-04	191	108	5	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND2A LAMA2 ITGA1 PKNOX2 LZTS1	1.02e-04	191	108	5	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 LZTS1	1.02e-04	191	108	5	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IL24 DENND2A TSHZ3 ITGA1 PKNOX2	1.02e-04	191	108	5	3d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND2A ADAMTS2 LAMA2 ITGA1 PKNOX2	1.02e-04	191	108	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 GRID1 ITGA1 LZTS1	1.02e-04	191	108	5	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 ITGA1 PKNOX2 ZFHX4	1.05e-04	192	108	5	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS2 LAMA2 ITGA1 PKNOX2 ZFHX4	1.05e-04	192	108	5	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ACSS1 ZFHX4 YAP1 MMD2 NOTCH2	1.05e-04	192	108	5	f7e4509003d71f805b9d4587098e90d2897b6739
Disease	free androgen index	HNF1A CYP19A1 FOXA3 PKNOX2 THADA ZFHX4 EHMT2 RIMS2	5.92e-05	374	105	8	EFO_0007005
Disease	congenital heart disease (implicated_via_orthology)	ITPR1 KMT2C SON MYBPC2	1.10e-04	69	105	4	DOID:1682 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ITPR1 STK4 THADA ZFHX4 ZFHX3 NOTCH2	1.23e-04	215	105	6	DOID:9970 (implicated_via_orthology)
Disease	acute pancreatitis (implicated_via_orthology)	REG3G REG3A	1.25e-04	5	105	2	DOID:2913 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	GGA2 LRRK2 STK4 YAP1 TOLLIP	1.74e-04	145	105	5	DOID:1289 (implicated_via_orthology)
Disease	Drugs used in diabetes use measurement	HNF1A TSHZ3 ITGA1 THADA ZFHX3 NOTCH2	3.09e-04	255	105	6	EFO_0009924
Disease	Neurodevelopmental Disorders	CDC42BPB ITPR1 KMT2C FOXP1	3.47e-04	93	105	4	C1535926
Disease	diet measurement	SLC4A8 ACSS1 LAMA2 GRID1 FAM186B ITPR1 THADA PRPF40B FOXP1 ZFHX3 DEPDC5 MBD5	3.58e-04	1049	105	12	EFO_0008111
Disease	Prostatic Neoplasms	IL24 CHST14 CYP19A1 FOXA3 ITPR1 KMT2C LZTS1 SP5 ZFHX3	3.61e-04	616	105	9	C0033578
Disease	Malignant neoplasm of prostate	IL24 CHST14 CYP19A1 FOXA3 ITPR1 KMT2C LZTS1 SP5 ZFHX3	3.61e-04	616	105	9	C0376358
Disease	serum gamma-glutamyl transferase measurement	HNF1A SLC4A8 ITGA1 CDC42BPB ITPR1 FARP2 THADA IGF1R NBEAL2 YY1AP1 NOTCH2	4.18e-04	914	105	11	EFO_0004532
Disease	formal thought disorder	PKNOX2 LZTS1	5.54e-04	10	105	2	EFO_0004805
Disease	pneumonia (implicated_via_orthology)	REG3G REG3A	5.54e-04	10	105	2	DOID:552 (implicated_via_orthology)
Disease	fibrinogen measurement, tissue plasminogen activator measurement	ATXN2L HNF1A FARP2	5.57e-04	45	105	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	ATXN2L HNF1A FARP2	5.57e-04	45	105	3	EFO_0004623, EFO_0004792
Disease	testosterone measurement	ATXN2L HNF1A CYP19A1 FOXA3 FARP2 PKNOX2 THADA LIPE ZFHX4 YAP1 FOXP1 ZFHX3 YY1AP1	6.00e-04	1275	105	13	EFO_0004908
Disease	central corneal thickness, intraocular pressure measurement	ADAMTS2 FOXP1	6.76e-04	11	105	2	EFO_0004695, EFO_0005213
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ATXN2L ITPR1	8.09e-04	12	105	2	DOID:1441 (implicated_via_orthology)
Disease	age of onset of multiple sclerosis	ITPR1 PER2	8.09e-04	12	105	2	OBA_2001029
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	ATXN2L HNF1A FARP2	1.06e-03	56	105	3	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	Adenocarcinoma Of Esophagus	ELMO1 FOXP1	1.11e-03	14	105	2	C0279628
Disease	sulfate measurement	HNF1A SLC13A1	1.11e-03	14	105	2	EFO_0007864
Disease	Diabetes Mellitus, Non-Insulin-Dependent	HNF1A ITGA1 THADA IRS2 NOTCH2	1.19e-03	221	105	5	C0011860
Disease	quinate measurement	LRRK2 GRID1	1.28e-03	15	105	2	EFO_0021167
Disease	pulse pressure measurement	ITGA1 FAM186B PIK3R4 ZFHX4 PRPF40B YAP1 RPTOR NAV1 REG3A FOXP1 ZFHX3 MBD5 CEP97	1.34e-03	1392	105	13	EFO_0005763
Disease	Malignant neoplasm of breast	IL24 CYP19A1 LAMA2 PIK3R4 LIPE IGF1R PER2 YAP1 USP54 KAT6B NOTCH2	1.55e-03	1074	105	11	C0006142
Disease	alcohol consumption measurement	ATXN2L HNF1A SLC4A8 ACSS1 GRID1 MFAP1 RPTOR XRN1 FOXP1 ZFHX3 RIMS2 CCDC33	1.55e-03	1242	105	12	EFO_0007878
Disease	sphingomyelin 14:0 measurement	THADA ZFHX3	1.65e-03	17	105	2	EFO_0010390
Disease	urate measurement, bone density	GRID1 ITPR1 POLR3E EHMT2 LZTS1 YAP1 NAV1 KAT6B	1.68e-03	619	105	8	EFO_0003923, EFO_0004531
Disease	Parkinson's disease (is_marker_for)	LRRK2 IGF1R SRRM2	1.78e-03	67	105	3	DOID:14330 (is_marker_for)
Disease	sphingosine 1-phosphate measurement	DAB1 ITPR1	1.85e-03	18	105	2	EFO_0800185
Disease	squamous cell carcinoma (is_implicated_in)	KMT2C LZTS1	1.85e-03	18	105	2	DOID:1749 (is_implicated_in)
Disease	response to ketamine	DAB1 FOXP1 ZFHX3	1.93e-03	69	105	3	EFO_0009748
Disease	attention function measurement	HNF1A HEATR1 ITPR1 LZTS1	1.96e-03	148	105	4	EFO_0007636
Disease	level of Sterol ester (27:1/20:3) in blood serum	HNF1A NOMO1	2.06e-03	19	105	2	OBA_2045199
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	TSHZ3 DAB1 LAMA2 FAM186B ELMO1 IGF1R PRPF40B FOXP1 ZFHX3	2.26e-03	801	105	9	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	colorectal cancer (is_marker_for)	HNF1A DICER1 YAP1 ZFHX3	2.43e-03	157	105	4	DOID:9256 (is_marker_for)
Disease	esophagus adenocarcinoma (is_implicated_in)	CYP19A1 FOXP1	2.52e-03	21	105	2	DOID:4914 (is_implicated_in)
Disease	Endometrioma	CYP19A1 LRRK2 DICER1 BRD8	2.66e-03	161	105	4	C0269102
Disease	Endometriosis	CYP19A1 LRRK2 DICER1 BRD8	2.66e-03	161	105	4	C0014175
Disease	circadian rhythm	HIKESHI PER2 FOXP1 BOLL	2.78e-03	163	105	4	EFO_0004354
Disease	alcohol drinking	HEATR1 TDRD7 MNT	3.05e-03	81	105	3	EFO_0004329
Disease	sphingomyelin measurement	HNF1A SLC4A8 TNRC6C FOXA3 LZTS1	3.21e-03	278	105	5	EFO_0010118
Disease	peptic ulcer disease, Peptic ulcer and gastro-oesophageal reflux disease (GORD) drug use measurement, gastroesophageal reflux disease	FOXP1 DEPDC5	3.29e-03	24	105	2	EFO_0003948, EFO_0009923, MONDO_0004247
Disease	Parkinson Disease	LRRK2 NCAPG2 IGF1R	3.50e-03	85	105	3	C0030567
Disease	cleft lip	THADA SLC13A1 LZTS1 GREM1 KAT6B	3.52e-03	284	105	5	EFO_0003959

Protein segments in the cluster

Peptide	Gene	Start	Entry
PAMAMRPFFGIVPVL	ACSS1	466	Q9NUB1
NPAMDFTQTPPGMLA	ELMO1	366	Q92556
ITPLSFPIPSMMNFD	CCDC33	431	Q8N5R6
FPIPSMMNFDVPRVS	CCDC33	436	Q8N5R6
QATIVMMPALPAPSS	BRD8	306	Q9H0E9
VPNVPTMLPRESSMA	ADGRG4	1491	Q8IZF6
QVYAPSAITMPAPVM	BOLL	256	Q8N9W6
PPSVQSLAMRLLSMP	EHMT2	141	Q96KQ7
QLFSPLPPSPMAMIR	FAM186B	366	Q8IYM0
PMMRPLIEKFSANVP	DICER1	1836	Q9UPY3
IDVFMPTLPVPTVAM	ADAMTS2	1116	O95450
QPVFAPMLQSNPRML	ATXN2L	811	Q8WWM7
MAANFTPPMQLAEIP	KAT6B	1771	Q8WYB5
ALINPFAPSRMPMKL	DEPDC5	596	O75140
MPAPALPTSAMAVQV	MAB21L4	1	Q08AI8
ARLPSVAFPTAMMPQ	NOTCH2	2346	Q04721
VMGFFPALVILSMPN	MMD2	191	Q8IY49
MSVPSALMKQPPIQS	MFAP1	1	P55081
SSMTRPVLMPNQDPF	KMT2C	2236	Q8NEZ4
STPPKLMPFSNQLEM	LZTS1	101	Q9Y250
TVLFKMFTSMDPPPV	NELFCD	311	Q8IXH7
TMMVTLNCPELQPPT	GREM1	151	O60565
FLPMTPMAAAPEGNV	ITPR1	951	Q14643
QKITEPSMFMNLAPP	C2CD6	256	Q53TS8
NPVLAPPSLSKMIQM	IGF1R	1101	P08069
FPAPLAPVMAFMLPS	PER2	896	O15055
ADMFLLVPPLMNPIV	OR51A7	276	Q8NH64
PPHMQVLLPALSPTM	DLAT	216	P10515
MALPITNGTLFMPFV	OR52A4P	1	A6NMU1
PALQVPVSVAMMTPQ	FOXP1	91	Q9H334
LSLPSSLPQMPMTQT	ILDR1	261	Q86SU0
PQTFPLTVTNRPMMD	NOMO1	481	Q15155
RMNFLAAMPFLPPSM	LRRK2	1161	Q5S007
AAMPFLPPSMTILKL	LRRK2	1166	Q5S007
TVLNPVTMVTMPSFP	MNT	561	Q99583
LMPPVQSHVTQSPFM	HNF1A	476	P20823
AFSPLMPPAVISQML	GGA2	556	Q9UJY4
QMVMSINLTGPLPAP	LAMA2	1591	P24043
MQVLMDLPLSAVPPS	CDC42BPB	1601	Q9Y5S2
PMPELKLSISFPNMT	ITGA1	996	P56199
SRIPMPVNFNEPLSM	OSBP2	536	Q969R2
DVSPPPLVVMAFSMK	POLA1	531	P09884
PFAMQNIDMPELFPS	ETAA1	391	Q9NY74
MPSVFSPDNPLMLSA	NUTM1	51	Q86Y26
SPMSPGMLRDVPQFL	RIMS2	791	Q9UQ26
MPMSPASVSAPKQIL	IRS2	676	Q9Y4H2
IPFMTPNTITMIPNT	NLGN4Y	771	Q8NFZ3
PATAAPSLLMSPMVF	DCP1B	516	Q8IZD4
PSLLMSPMVFAQPTS	DCP1B	521	Q8IZD4
FALQTMEPALPMPPV	DAAM1	36	Q9Y4D1
LPVMQFSVMPVFVPT	ATMIN	306	O43313
AQMTPSPSEMFIPAN	HIKESHI	161	Q53FT3
PAAFMPTQTVMPLPA	DAB1	396	O75553
PTQTVMPLPAAMFQG	DAB1	401	O75553
IVPEAMPAATMPVLL	CYP19A1	16	P11511
QPLMRSVMEAPFPAL	DENND2A	696	Q9ULE3
IPKMVPAEMSSPALA	DYTN	491	A2CJ06
SIMNNPCVMATPSIP	CEP97	201	Q8IW35
PFCPPLLATASQMQM	IL24	16	Q13007
DPTPSQNPLSLMMTQ	BCL9L	1076	Q86UU0
APVRPVTLNMNVAMP	LYPLA1	56	O75608
NTMFPPTANMLLPTG	MBD5	621	Q9P267
LPLPLSSSATMPSMQ	GRID1	951	Q9ULK0
AQAVLPSMAQMLPPQ	KLF17	201	Q5JT82
PQLPSLMPSLLTTMK	HEATR1	1731	Q9H583
MPATLMTLLFSNIDP	FARP2	571	O94887
SVTALLPSLMLPMFG	SLC13A1	56	Q9BZW2
VMPFANLMSLLGPSI	POLR3E	291	Q9NVU0
SPAPALTMMATQNVP	PKNOX2	6	Q96KN3
SHPMLATFPMLLEQP	NPHP1	606	O15259
KNPFMSPLLAPDSML	LIPE	966	Q05469
MLPPMALPSVSWMLL	REG3G	1	Q6UW15
ESLQMPMSLPSAFPS	NAV1	886	Q8NEY1
MLPPMALPSVSWMLL	REG3A	1	Q06141
MLCQLLPMQPVPESS	THADA	1066	Q6YHU6
PALLTSPINPQHMTM	TNRC6C	1136	Q9HCJ0
SPVKMLPSSMAALPA	SP5	126	Q6BEB4
ARMSQVPAPVPLMSL	SRRM2	2206	Q9UQ35
FAPPLSPLSSDMLIM	PWWP3B	236	Q5H9M0
VPTMAPLNSYMTLNP	FOXA3	31	P55318
FDLTPSMAGIMVPPV	NBEAL2	581	Q6ZNJ1
NMPPRLPANTMQLFL	KERA	206	O60938
ALASQMPPPLTTGLM	PRRC2C	2761	Q9Y520
SVPMTAVPPFMDGLQ	SHISA2	256	Q6UWI4
ASPAAIVFPMMVLAL	SLC4A8	971	Q2Y0W8
NTFMEDITVPPLMIP	TDRD7	446	Q8NHU6
MPLPPSMKNCIQLAA	RPTOR	231	Q8N122
GPPLLLPSMLMFAVI	CHST14	36	Q8NCH0
PKESPAMLPTFLLMN	NCAPD2	911	Q15021
LFMLMSFMPASAVPP	NCAPG2	671	Q86XI2
MEPSKTFMRNLPITP	C10orf82	1	Q8WW14
SMFGSLDPPNMPQAL	PIK3R4	861	Q99570
VSLDLPLFPSIMMQP	ZFHX4	2026	Q86UP3
MNLPTPMTLAAPLNI	VEZF1	486	Q14119
PMTLAAPLNIAMRPV	VEZF1	491	Q14119
APLNIAMRPVESMPF	VEZF1	496	Q14119
AMRPVESMPFLPQAL	VEZF1	501	Q14119
SYALLPAAMVMPPQP	TOLLIP	171	Q9H0E2
MLSQMNVTAPTSPPV	YAP1	206	P46937
PQPDFSFLRMPQTMT	XRN1	1456	Q8IZH2
AAPAPSLFPAAQMMN	MRPL2	21	Q5T653
MLMPAVPVTAATAPG	PRPF40B	66	Q6NWY9
AAKPSLPALDPMSML	TSHZ3	736	Q63HK5
APFTSIPSMMTQPLL	ZBTB39	216	O15060
STFSALTPVMLMEPP	TRIM17	401	Q9Y577
QTLLSSAPVPKVMMP	YY1AP1	546	Q9H869
TPMALQVQLAMSPSP	TOX2	416	Q96NM4
DIHPMRAIFMIPTNP	STK4	226	Q13043
QTIAQGMAPPPVSMA	ZC3H10	371	Q96K80
QAPMSSAMLLVAVPF	SLC35E3	191	Q7Z769
PPAMAAPESSAMAVL	SON	1346	P18583
PPAKMSVMLPSVNLE	KIAA0586	1496	Q9BVV6
TQLSMPMELPIFSPL	ZFHX3	2086	Q15911
PQPQFLSPDVLMPTM	USP54	1476	Q70EL1
VSQPSMNTKPFMPIA	MYBPC2	721	Q14324