Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.10e-05	3	40	2	GO:0002879
GeneOntologyBiologicalProcess	regulation of norepinephrine secretion	ADORA2A FFAR3 GPR42	1.70e-05	26	40	3	GO:0014061
GeneOntologyBiologicalProcess	norepinephrine secretion	ADORA2A FFAR3 GPR42	2.14e-05	28	40	3	GO:0048243
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	2.19e-05	4	40	2	GO:0002877
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	3.65e-05	5	40	2	GO:0002525
GeneOntologyBiologicalProcess	norepinephrine transport	ADORA2A FFAR3 GPR42	5.44e-05	38	40	3	GO:0015874
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	5.47e-05	6	40	2	GO:1904457
GeneOntologyBiologicalProcess	regulation of amine transport	ADORA2A FFAR3 GPR42 NTSR1	9.92e-05	125	40	4	GO:0051952
GeneOntologyBiologicalProcess	regulation of heart rate by chemical signal	FFAR3 GPR42	1.31e-04	9	40	2	GO:0003062
GeneOntologyBiologicalProcess	amine transport	ADORA2A FFAR3 GPR42 NTSR1	1.41e-04	137	40	4	GO:0015837
GeneOntologyBiologicalProcess	positive regulation of nervous system process	FFAR3 GPR42 NTSR1	1.84e-04	57	40	3	GO:0031646
GeneOntologyBiologicalProcess	negative regulation of insulin secretion	PFKL FFAR3 GPR42	2.36e-04	62	40	3	GO:0046676
GeneOntologyBiologicalProcess	positive regulation of transmission of nerve impulse	FFAR3 GPR42	2.82e-04	13	40	2	GO:0051971
GeneOntologyBiologicalProcess	regulation of catecholamine secretion	ADORA2A FFAR3 GPR42	2.97e-04	67	40	3	GO:0050433
GeneOntologyBiologicalProcess	negative regulation of blood pressure	FFAR3 GPR42 NTSR1	3.38e-04	70	40	3	GO:0045776
GeneOntologyBiologicalProcess	positive regulation of glutamate secretion	ADORA2A NTSR1	3.79e-04	15	40	2	GO:0014049
GeneOntologyBiologicalProcess	regulation of neuronal action potential	FFAR3 GPR42	3.79e-04	15	40	2	GO:0098908
GeneOntologyBiologicalProcess	negative regulation of synapse assembly	PTK2 SLIT1	3.79e-04	15	40	2	GO:0051964
GeneOntologyBiologicalProcess	negative regulation of peptide hormone secretion	PFKL FFAR3 GPR42	3.82e-04	73	40	3	GO:0090278
GeneOntologyBiologicalProcess	negative regulation of peptide secretion	PFKL FFAR3 GPR42	4.14e-04	75	40	3	GO:0002792
GeneOntologyBiologicalProcess	catecholamine secretion	ADORA2A FFAR3 GPR42	4.82e-04	79	40	3	GO:0050432
GeneOntologyBiologicalProcess	positive regulation of action potential	FFAR3 GPR42	5.50e-04	18	40	2	GO:0045760
GeneOntologyBiologicalProcess	negative regulation of synapse organization	PTK2 SLIT1	7.52e-04	21	40	2	GO:1905809
MousePheno	abnormal sympathetic neuron innervation pattern	FFAR3 GPR42	1.93e-05	3	36	2	MP:0009284
MousePheno	abnormal sympathetic neuron physiology	FFAR3 GPR42	3.86e-05	4	36	2	MP:0009253
MousePheno	decreased circulating noradrenaline level	FFAR3 GPR42	1.34e-04	7	36	2	MP:0005664
Domain	GPR40-rel_orph	FFAR3 GPR42	2.95e-05	4	42	2	IPR013312
Domain	NUT	NUTM2F NUTM2G	4.92e-05	5	42	2	IPR024310
Domain	NUT_N	NUTM2F NUTM2G	4.92e-05	5	42	2	IPR024309
Domain	NUT	NUTM2F NUTM2G	4.92e-05	5	42	2	PF12881
Domain	hEGF	FBN3 SLIT1	1.80e-03	28	42	2	PF12661
Pathway	WP_GPCRS_NONODORANT	FZD7 ADORA2A FFAR3 GPR42 NTSR1	1.32e-04	266	27	5	MM15843
Pathway	REACTOME_GLUCOSE_METABOLISM	RANBP2 PFKL NUP205	5.02e-04	82	27	3	MM15394
Pathway	REACTOME_GLUCOSE_METABOLISM	RANBP2 PFKL NUP205	5.57e-04	85	27	3	M1870
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY	ITGB6 PTK2	8.72e-04	23	27	2	M47720
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY	ITGB6 PTK2	1.12e-03	26	27	2	M47719
Pathway	REACTOME_APOPTOSIS	BIRC8 CLSPN PTK2	1.12e-03	108	27	3	MM14471
Pathway	REACTOME_TRNA_PROCESSING	RANBP2 OSGEP NUP205	1.21e-03	111	27	3	M27684
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	ADORA2A FFAR3 GPR42 NTSR1	1.42e-03	260	27	4	M39397
Pathway	KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA	RANBP2 NUP205	1.49e-03	30	27	2	M47752
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY	ITGB6 PTK2	1.49e-03	30	27	2	M47724
Pathway	KEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY	ITGB6 PTK2	1.49e-03	30	27	2	M47718
Pathway	WP_HIPPOMERLIN_SIGNALING_DYSREGULATION	ITGB6 PTK2 PPP1R12A	1.55e-03	121	27	3	M39823
Pathway	PID_SYNDECAN_4_PATHWAY	FZD7 PTK2	1.69e-03	32	27	2	M165
Pathway	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	RANBP2 NUP205	1.69e-03	32	27	2	M29579
Pathway	REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS	RANBP2 NUP205	1.80e-03	33	27	2	M27016
Pathway	REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN	RANBP2 NUP205	1.91e-03	34	27	2	M27041
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RANBP2 NUP205	2.02e-03	35	27	2	M27320
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RANBP2 NUP205	2.14e-03	36	27	2	M27245
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RANBP2 NUP205	2.14e-03	36	27	2	M26974
Pathway	REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS	RANBP2 NUP205	2.26e-03	37	27	2	M1029
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	ITGB6 FBN3	2.26e-03	37	27	2	M27134
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	RANBP2 NUP205	2.26e-03	37	27	2	M27038
Pathway	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS	CLSPN PTK2	2.26e-03	37	27	2	MM14488
Pathway	REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS	CLSPN PTK2	2.38e-03	38	27	2	M495
Pathway	REACTOME_PROGRAMMED_CELL_DEATH	BIRC8 CLSPN PTK2	2.45e-03	142	27	3	MM15178
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RANBP2 NUP205	2.51e-03	39	27	2	M27238
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	RANBP2 NUP205	2.63e-03	40	27	2	MM14945
Pathway	REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS	RANBP2 NUP205	2.77e-03	41	27	2	M29574
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	RANBP2 NUP205	2.77e-03	41	27	2	MM15200
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	RANBP2 NUP205	2.90e-03	42	27	2	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	RANBP2 NUP205	3.04e-03	43	27	2	MM14609
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	RANBP2 NUP205	3.04e-03	43	27	2	M26975
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	RANBP2 NUP205	3.18e-03	44	27	2	M109
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	ITGB6 FBN3	3.18e-03	44	27	2	M26969
Pathway	REACTOME_NETRIN_1_SIGNALING	PTK2 SLIT1	3.18e-03	44	27	2	M875
Pathway	PID_PLK1_PATHWAY	CLSPN PPP1R12A	3.47e-03	46	27	2	M129
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	RANBP2 NUP205	3.47e-03	46	27	2	M27397
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	ADORA2A FFAR3 GPR42 NTSR1	3.49e-03	333	27	4	MM14963
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	RANBP2 NUP205	3.62e-03	47	27	2	MM14939
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	RANBP2 NUP205	3.62e-03	47	27	2	M27395
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	1.42e-06	2	42	2	20399779
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	1.42e-06	2	42	2	25637492
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	1.42e-06	2	42	2	19630535
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	1.42e-06	2	42	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	1.42e-06	2	42	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	1.42e-06	2	42	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	1.42e-06	2	42	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	1.42e-06	2	42	2	27550964
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	1.42e-06	2	42	2	23110765
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	1.42e-06	2	42	2	35858247
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	1.42e-06	2	42	2	26522986
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	1.42e-06	2	42	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	1.42e-06	2	42	2	32073900
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	1.42e-06	2	42	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	1.42e-06	2	42	2	27664183
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	1.42e-06	2	42	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	1.42e-06	2	42	2	36362376
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	1.42e-06	2	42	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	1.42e-06	2	42	2	37019194
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	4.27e-06	3	42	2	22673524
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	4.27e-06	3	42	2	12496283
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	4.27e-06	3	42	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	4.27e-06	3	42	2	25581519
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	4.27e-06	3	42	2	23665276
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	4.27e-06	3	42	2	22190648
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	4.27e-06	3	42	2	34210970
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	4.27e-06	3	42	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	4.27e-06	3	42	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	4.27e-06	3	42	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	4.27e-06	3	42	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	4.27e-06	3	42	2	38524121
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	4.27e-06	3	42	2	31719611
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	4.27e-06	3	42	2	38329121
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	4.27e-06	3	42	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	4.27e-06	3	42	2	22493486
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	8.53e-06	4	42	2	21518883
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	8.53e-06	4	42	2	23401498
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	8.53e-06	4	42	2	15684720
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	8.53e-06	4	42	2	9344866
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	8.53e-06	4	42	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	8.53e-06	4	42	2	29644622
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	1.42e-05	5	42	2	24327954
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	1.42e-05	5	42	2	19009545
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	1.42e-05	5	42	2	19047060
Pubmed	Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.	DHX36 RANBP2 CD5 PPP1R12A	2.04e-05	133	42	4	15144186
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	2.13e-05	6	42	2	19460454
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	USP36 PFAS RANBP2 FLG2 PPP1R12A LRRFIP1	2.23e-05	477	42	6	31300519
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	USP36 RANBP2 DHRS2 PFKL PTK2 PPP1R12A LRRFIP1	2.36e-05	724	42	7	36232890
Pubmed	The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.	RANBP2 NUP205	2.98e-05	7	42	2	20547757
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	3.97e-05	8	42	2	34626852
Pubmed	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.	ADORA2A SLIT1 ZNF503	4.11e-05	55	42	3	32561725
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	USP36 DHX36 PHF14 LRRFIP1 NUP205	4.90e-05	332	42	5	25693804
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	RANBP2 PTK2 LRRFIP1 NUP205	1.04e-04	202	42	4	24639526
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX36 PFAS PFKL GALNT2 CLSPN PTK2	1.23e-04	650	42	6	38777146
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	RANBP2 PFKL FLG2 PPP1R12A LRRFIP1 NUP205	1.34e-04	660	42	6	32780723
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42	1.48e-04	15	42	2	32641826
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	USP36 DHX36 PFAS RANBP2 DHRS2 PFKL PTK2 NUP205	1.86e-04	1353	42	8	29467282
Pubmed	The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.	RANBP2 NUP205	1.91e-04	17	42	2	10668806
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	RANBP2 PTK2	3.86e-04	24	42	2	16620772
Pubmed	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	RANBP2 NUP205	4.20e-04	25	42	2	10601273
Pubmed	Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.	RANBP2 NUP205	4.54e-04	26	42	2	12228227
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	RANBP2 NUP205	6.06e-04	30	42	2	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	RANBP2 NUP205	6.06e-04	30	42	2	27016207
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	FZD7 PTK2	6.47e-04	31	42	2	32546759
Pubmed	Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum.	ADORA2A ZNF503	6.90e-04	32	42	2	35156680
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	RANBP2 PFKL FLG2 NUP205	7.49e-04	340	42	4	29478914
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	DHX36 PFAS PFKL OSGEP	7.83e-04	344	42	4	30333137
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DHX36 PFAS RANBP2 OSGEP PTK2 PPP1R12A NUP205	8.00e-04	1284	42	7	17353931
Pubmed	Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.	TBC1D31 CLSPN	9.74e-04	38	42	2	36674791
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	RANBP2 NUP205	1.08e-03	40	42	2	37516964
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX36 PFAS RANBP2 CUL7 NUP205	1.10e-03	653	42	5	22586326
Pubmed	Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.	FZD7 PKD1L2	1.13e-03	41	42	2	18951430
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	USP36 DHX36 PHF14 RANBP2 CLSPN NUP205	1.14e-03	989	42	6	36424410
Pubmed	Parcellation of the striatal complex into dorsal and ventral districts.	ADORA2A ZNF503	1.19e-03	42	42	2	32170006
Cytoband	19q13.1	FFAR3 GPR42	1.18e-03	55	42	2	19q13.1
Cytoband	2q37.3	ANKMY1 LRRFIP1	2.29e-03	77	42	2	2q37.3
GeneFamily	Nucleoporins	RANBP2 NUP205	1.04e-03	32	27	2	1051
Disease	bowel opening frequency	FFAR3 GPR42	7.61e-04	30	40	2	EFO_0600084
Disease	Mood Disorders	ADORA2A PFKL NTSR1	1.53e-03	168	40	3	C0525045
Disease	Rheumatoid Arthritis	ADORA2A CD5 PTK2	1.70e-03	174	40	3	C0003873
Disease	left ventricular diastolic function measurement	PHF14 PTK2	2.45e-03	54	40	2	EFO_0008204
Disease	Disproportionate short stature	IFT80 CUL7	4.92e-03	77	40	2	C0878659

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGTGQAECQVVVATH	nan	86	Q6ZR03
QQGIQECREACGGHG	ACOX3	416	O15254
EGKNHSQGCGEGQVA	ADORA2A	151	P29274
LVAQSGGQHCAGVVE	CD5	161	P06127
NVSGTGQVCTGVHVG	CD300LD-AS1	136	Q96MU5
VQNGGCDVHCINTEG	FBN3	1161	Q75N90
VCQGGDITKHDGTGG	RANBP2	3121	P49792
VNGSSHVENIQGAGG	NUP205	536	Q92621
GFEQHVCGSGQTCGQ	FLG2	441	Q5D862
AEQGQVCTVGGEHST	NTSR1	271	P30989
GVVGVYECHNAGGNQ	GALNT2	466	Q10471
NDHVQGGCALGGAET	ITGB6	16	P18564
VQHGITNLCVIGGDG	PFKL	106	P17858
GDGGSGQVDCKAEHI	CUL7	51	Q14999
HCGSQEALIVGGVGC	OSGEP	251	Q9NPF4
HSQGCGTGGQVACAE	GPR42	331	O15529
NCGITVHEGCYGVDG	PHF14	341	O94880
CEGQGGHLVFIQDEG	PKD1L2	56	Q7Z442
AGEICVGQNTSDGSG	FZD7	156	O75084
GTQIAGACGNGHVVF	IFT80	281	Q9P2H3
GEVVENTHNVGAGGC	GKN2	151	Q86XP6
IGQEDKVQCFHCGGG	BIRC8	31	Q96P09
DNHQVTVISGETGCG	DHX36	221	Q9H2U1
HSQGCGTGGQVACAE	FFAR3	331	O14843
GGHFQDTGQCGGSID	ANKMY1	411	Q9P2S6
LEDAGAQQGDGCGHT	DCBLD2	61	Q96PD2
QGEGLSVAGIVCHVG	DHRS2	81	Q13268
GGNHTENVGEAAVTQ	LRRFIP1	416	Q32MZ4
TSAQVVGGTQACEGG	NUTM2F	136	A1L443
TSAQVVGGTQACEGG	NUTM2G	136	Q5VZR2
DGTGDCLIAGDHQGN	TBC1D31	51	Q96DN5
GSQLGHCISENEGGA	TMEM121B	551	Q9BXQ6
RCIGEGQFGDVHQGI	PTK2	426	Q05397
VLIVHGDSGCQGDGQ	TMEM151A	451	Q8N4L1
GNNHSEECQVGGLVA	CLSPN	436	Q9HAW4
ICSLHDQGAGGNGNV	PFAS	511	O15067
NDSVVQCIVGDHAGG	PKHD1L1	1961	Q86WI1
HGRISCGGGINVDVN	ZNF503	281	Q96F45
CGGGINVDVNQHPDG	ZNF503	286	Q96F45
DHACANGGVCVDGVG	SLIT1	1011	O75093
VNGQQVGCVTDGHHA	USP36	896	Q9P275
EGNCHFEQHQGQEEG	ZNF461	146	Q8TAF7
SAGGVGDCQGVEGSQ	TMED8	21	Q6PL24
IGQGAHVGAVNSEGD	PPP1R12A	126	O14974