Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytidylate cyclase activity	GUCY1A1 GUCY1B1	3.83e-05	2	124	2	GO:0047805
GeneOntologyBiologicalProcess	trans-synaptic signaling by soluble gas, modulating synaptic transmission	GUCY1A1 GUCY1B1	3.59e-05	2	124	2	GO:0099554
GeneOntologyBiologicalProcess	trans-synaptic signaling by nitric oxide, modulating synaptic transmission	GUCY1A1 GUCY1B1	3.59e-05	2	124	2	GO:0099555
Domain	LRR	PODNL1 LRRC24 STK11IP SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	9.38e-07	201	124	10	PS51450
Domain	-	PODNL1 LRRC24 PRAMEF19 PRAMEF18 STK11IP SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	1.54e-06	321	124	12	3.80.10.10
Domain	L_dom-like	PODNL1 LRRC24 PRAMEF19 PRAMEF18 STK11IP SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	1.93e-06	328	124	12	IPR032675
Domain	LRR_8	PODNL1 LRRC24 SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	2.11e-06	171	124	9	PF13855
Domain	LRR_TYP	PODNL1 LRRC24 SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	2.80e-06	177	124	9	SM00369
Domain	Leu-rich_rpt_typical-subtyp	PODNL1 LRRC24 SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	2.80e-06	177	124	9	IPR003591
Domain	LRRNT	PODNL1 LRRC24 SLITRK1 TSKU TRIL PXDN TPBG	4.02e-06	98	124	7	IPR000372
Domain	LRRNT	PODNL1 LRRC24 SLITRK1 TSKU TRIL PXDN TPBG	4.02e-06	98	124	7	SM00013
Domain	Leu-rich_rpt	PODNL1 LRRC24 STK11IP SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	1.34e-05	271	124	10	IPR001611
Domain	LRR_1	PODNL1 LRRC24 SLITRK1 TLR8 TSKU TRIL PXDN TPBG PHLPP2	1.57e-05	219	124	9	PF00560
Domain	Cys-rich_flank_reg_C	LRRC24 SLITRK1 TLR8 TRIL PXDN TPBG	2.99e-05	90	124	6	IPR000483
Domain	LRRCT	LRRC24 SLITRK1 TLR8 TRIL PXDN TPBG	2.99e-05	90	124	6	SM00082
Domain	PC_rep	PSMD2 ANAPC1	1.31e-04	3	124	2	PF01851
Domain	Proteasome/cyclosome_rpt	PSMD2 ANAPC1	1.31e-04	3	124	2	IPR002015
Domain	HNOB	GUCY1A1 GUCY1B1	2.60e-04	4	124	2	PF07700
Domain	HNOB_dom_associated	GUCY1A1 GUCY1B1	6.45e-04	6	124	2	IPR011645
Domain	HNOBA	GUCY1A1 GUCY1B1	6.45e-04	6	124	2	PF07701
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 TMEM120B LRRC24 PFAS STK11IP ANO8 PLEKHH3 ARHGEF10L TYK2 RGMA KMT2C TLK1 MROH1 SH3TC1 FURIN KBTBD11 HERC2 D2HGDH	1.18e-07	1105	127	18	35748872
Pubmed	Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase.	CAND2 PSMD2 PSMD6	9.43e-07	6	127	3	12692129
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	TLK2 RASGRP4 RBM15 PSMD2 PFAS ZSWIM6 NCAPG2 TBL3 KMT2C MTRF1 TLK1 ANAPC1 RECQL5 DDX54 SMS ALG12 CAPN15	7.06e-06	1327	127	17	32694731
Pubmed	Structural insights into the mechanism of human soluble guanylate cyclase.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	31514202
Pubmed	Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	28465505
Pubmed	Mural Wnt/β-catenin signaling regulates Lama2 expression to promote neurovascular unit maturation.	APCDD1 LAMA2	1.32e-05	2	127	2	36098369
Pubmed	The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.	TLK2 TLK1	1.32e-05	2	127	2	21647934
Pubmed	Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	1352257
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.32e-05	2	127	2	11687802
Pubmed	Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	8097486
Pubmed	Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.	TLK2 TLK1	1.32e-05	2	127	2	32755577
Pubmed	cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.	TLK2 TLK1	1.32e-05	2	127	2	9427565
Pubmed	Genomic organization of alpha1 and beta1 subunits of the mammalian soluble guanylyl cyclase genes.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	10984516
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.32e-05	2	127	2	34910522
Pubmed	Crystal structures of the catalytic domain of human soluble guanylate cyclase.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	23505436
Pubmed	Quaternary structure controls ligand dynamics in soluble guanylate cyclase.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	22223482
Pubmed	Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	29024896
Pubmed	Inflammation in the Human Periodontium Induces Downregulation of the α1- and β1-Subunits of the sGC in Cementoclasts.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	33430449
Pubmed	Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	17855621
Pubmed	Differential expression of alternative transcripts of soluble guanylyl cyclase, GYCY1a3 and GUCY1b3 genes, in the malignant and benign breast tumors.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	30597209
Pubmed	Human soluble guanylate cyclase: functional expression and revised isoenzyme family.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	9742212
Pubmed	sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	19502556
Pubmed	Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	18339647
Pubmed	Synergistic mutations in soluble guanylyl cyclase (sGC) reveal a key role for interfacial regions in the sGC activation mechanism.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	31645439
Pubmed	cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.	GUCY1A1 GUCY1B1	1.32e-05	2	127	2	8613461
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GPAM ZSWIM6 SEMA4G ANO8 ARHGEF10L	3.59e-05	101	127	5	10997877
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	3.96e-05	3	127	2	30801007
Pubmed	Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.	GUCY1A1 GUCY1B1	3.96e-05	3	127	2	22095726
Pubmed	Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.	TLK2 TLK1	3.96e-05	3	127	2	28535374
Pubmed	CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells.	PDPK1 CPT1A	3.96e-05	3	127	2	38494680
Pubmed	Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.	GUCY1A1 GUCY1B1	3.96e-05	3	127	2	17610859
Pubmed	The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.	TLK2 TLK1	3.96e-05	3	127	2	38498025
Pubmed	Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.	GUCY1A1 GUCY1B1	3.96e-05	3	127	2	19478201
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	3.96e-05	3	127	2	21347312
Pubmed	Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.	MPL RBM15	3.96e-05	3	127	2	25468569
Pubmed	The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.	GUCY1A1 GUCY1B1	3.96e-05	3	127	2	22690686
Pubmed	Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.	GUCY1A1 GUCY1B1	3.96e-05	3	127	2	24733395
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	TMEM120B SH2D2A SLITRK1 AK8 KMT2C SH3TC1 TRAM2	5.65e-05	265	127	7	19240061
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	7.90e-05	4	127	2	18849963
Pubmed	Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.	TLK2 TLK1	7.90e-05	4	127	2	10523312
Pubmed	Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.	TLK2 TLK1	7.90e-05	4	127	2	11470414
Pubmed	Proteolytic processing of human zona pellucida proteins.	FURIN ZP4	7.90e-05	4	127	2	11804956
Pubmed	Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.	TLK2 TLK1	7.90e-05	4	127	2	20016786
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	CAND2 MAGED1 PFAS STK11IP PSMD6 NSUN5 ANAPC1 DDX54 HLTF HERC2	8.08e-05	606	127	10	36538041
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PFAS GPAM SLITRK1 SEMA4G ANO8 TLK1 FAT2 LTN1 PRORP	8.69e-05	493	127	9	15368895
Pubmed	Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.	MAGED1 PSMD2 CPT1A PSMD6	1.29e-04	70	127	4	21726808
Pubmed	Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.	FURIN ADAMTS17	1.31e-04	5	127	2	23661674
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF19 PRAMEF18	1.31e-04	5	127	2	16159394
Pubmed	Tousled-like kinase in a microbial eukaryote regulates spindle assembly and S-phase progression by interacting with Aurora kinase and chromatin assembly factors.	TLK2 TLK1	1.31e-04	5	127	2	17940067
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.31e-04	5	127	2	24920589
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	MAGED1 PLEKHG4 STK11IP NCAPG2 TSKU MROH1 FURIN LTN1 SLC35F6 SMS UBIAD1 PRAF2 TPBG	1.42e-04	1061	127	13	33845483
Pubmed	Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.	GUCY1A1 GUCY1B1 FURIN	1.62e-04	29	127	3	21909115
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	TLK2 RBM15 ZBTB9 ARHGAP11A NCAPG2 RECQL5	1.72e-04	222	127	6	37071664
Pubmed	NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.	PDPK1 MAP3K14	1.97e-04	6	127	2	18439422
Pubmed	Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.	TLK2 TLK1	1.97e-04	6	127	2	12660173
Pubmed	Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.	GUCY1A1 GUCY1B1	1.97e-04	6	127	2	19345227
Pubmed	Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	BOC PLEKHG4 SH3TC1 SIGLEC1	2.73e-04	85	127	4	15449545
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS17 ADAMTS15	2.75e-04	7	127	2	11867212
Pubmed	Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.	ESRRB FURIN	2.75e-04	7	127	2	15505202
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	LTN1 HERC2	2.75e-04	7	127	2	36700049
Pubmed	Angelman syndrome-associated point mutations in the Zn2+-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome.	PSMD2 PSMD6 HERC2	2.86e-04	35	127	3	30257870
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	3.65e-04	8	127	2	21165971
Pubmed	A HECT domain E3 enzyme assembles novel polyubiquitin chains.	CAND2 PSMD2	3.65e-04	8	127	2	11278995
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	SYNGAP1 STRC STRCP1	3.65e-04	38	127	3	38346162
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	NAT8L ZSWIM6 NCAPG2 ANO8 ARHGEF10L SYNGAP1 SH3TC1 DDX54 ADAMTS15 TM7SF2 GNL1 D2HGDH	3.75e-04	1021	127	12	26760575
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	RBM15 MAGED1 RSL1D1 PSMD2 PSMD6 DDX54 HLTF PHLPP2	4.62e-04	491	127	8	36273042
Pubmed	Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons.	GUCY1A1 GUCY1B1	4.68e-04	9	127	2	24155296
Pubmed	HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.	GUCY1A1 GUCY1B1	4.68e-04	9	127	2	24666322
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	PDPK1 SKIDA1 PSMD2 PSMD6 KMT2C ANAPC1 DDX54 D2HGDH	4.87e-04	495	127	8	27705803
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PITPNM2 ANKS1B SYNGAP1 PIP5KL1 KBTBD11 PRAF2	6.02e-04	281	127	6	28706196
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	PSMD2 PFAS CPT1A STK11IP PLEKHH3 SLC35F6 STARD3	6.15e-04	392	127	7	33144569
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	RASGRP4 CAND2 PRAMEF19 FRMD7 SKIDA1 ANKS1B PRAMEF18 TMC3 SNIP1 SLC35F6 SMS PRAF2 TRAM2	6.36e-04	1242	127	13	30973865
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	MAGED1 RSL1D1 PSMD2 NSUN5 HLTF VRTN PRORP	6.53e-04	396	127	7	26687479
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	MAGED1 PFAS GPAM NCAPG2 TYK2 AP5B1 HLTF STARD3 SLC25A17	6.61e-04	650	127	9	38777146
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RBM15 CAND2 MAGED1 RSL1D1 PSMD2 PFAS CPT1A NCAPG2 TBL3 PSMD6 NSUN5 ANAPC1 HLTF	7.11e-04	1257	127	13	37317656
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	GUCY1A1 GUCY1B1	7.12e-04	11	127	2	15381706
Pubmed	Stable incorporation of ATPase subunits into 19 S regulatory particle of human proteasome requires nucleotide binding and C-terminal tails.	PSMD2 PSMD6	7.12e-04	11	127	2	22275368
Pubmed	Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.	BOC LFNG	7.12e-04	11	127	2	29139542
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	7.12e-04	11	127	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	7.12e-04	11	127	2	31776257
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TLK2 RBM15 RSL1D1 ZBTB9 TTC9C NCAPG2 PSMD6 KMT2C NSUN5 TLK1 HLTF SMS	7.41e-04	1103	127	12	34189442
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CAND2 PSMD2 PFAS CPT1A NCAPG2 TYK2 PSMD6 LTN1 DDX54 SMS PRORP	9.14e-04	974	127	11	28675297
Pubmed	Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.	LRRC24 SLITRK1 TPBG	9.22e-04	52	127	3	24613359
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	RBM15 CAND2 PSMD2 LTN1 HERC2 SLC25A17	1.05e-03	313	127	6	38270169
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PITPNM2 TMEM120B SPATA6 ZSWIM6 CPT1A ANO8 TYK2 KMT2C TLK1 PXDN SH3TC1 GUCY1A1 PRORP ALG12	1.11e-03	1489	127	14	28611215
Pubmed	Genomic analysis of mouse retinal development.	PITPNM2 NAT8L ESRRB PSMD2 CPT1A ARHGAP11A CENPK SEMA4G MOCS3 KBTBD11 PHLPP2	1.19e-03	1006	127	11	15226823
Pubmed	Integral and associated lysosomal membrane proteins.	STK11IP AP5B1 SLC35F6 STARD3	1.20e-03	126	127	4	17897319
Pubmed	Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.	PSMD2 PSMD6 HERC2	1.27e-03	58	127	3	22645313
Pubmed	Mammalian Cdh1/Fzr mediates its own degradation.	PSMD2 PSMD6 ANAPC1	1.33e-03	59	127	3	15029244
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RBM15 PLEKHG4 RSL1D1 PSMD2 PFAS NCAPG2 TBL3 NSUN5 RECQL5 LTN1 DDX54 HLTF HERC2	1.38e-03	1353	127	13	29467282
Pubmed	RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.	HLTF HERC2	1.54e-03	16	127	2	26474068
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	BOC PLVAP PGLYRP2 SLITRK1 TLR8 TSKU TPBG	1.55e-03	460	127	7	20562862
Pubmed	Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.	STK11IP SLITRK1 SYNGAP1	1.61e-03	63	127	3	11572484
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 RBM15 RSL1D1 FAT2 DDX54	1.73e-03	234	127	5	36243803
Pubmed	Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.	TLK2 TLK1	1.74e-03	17	127	2	28708136
Pubmed	Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.	MAGED1 PXDN	1.74e-03	17	127	2	12023963
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF19 PRAMEF18	1.74e-03	17	127	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF19 PRAMEF18	1.74e-03	17	127	2	37781892
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	1.74e-03	17	127	2	20856818
Pubmed	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint.	PSMD2 PSMD6 ANAPC1	1.92e-03	67	127	3	11285280
GeneFamily	Guanylate cyclases, soluble	GUCY1A1 GUCY1B1	1.04e-04	4	76	2	820
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD7 PLEKHH3 TYK2	1.21e-03	50	76	3	1293
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS17 ADAMTS15	2.85e-03	19	76	2	50
GeneFamily	G protein-coupled receptors, Class A orphans	GPR4 GPR146 GPR62	4.33e-03	78	76	3	262
GeneFamily	Beta 3-glycosyltransferases	B3GNT4 LFNG	4.53e-03	24	76	2	426
GeneFamily	PRAME family	PRAMEF19 PRAMEF18	4.53e-03	24	76	2	686
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC LRRC24 PXDN SIGLEC1	4.73e-03	161	76	4	593
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BOC SPATA6 APCDD1 ANKS1B LAMA2 RGMA PXDN	1.16e-06	188	127	7	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	MAGED1 LAMA2 TSKU TRIL GUCY1A1 GUCY1B1 ADAMTS17	1.21e-06	189	127	7	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	BOC SPATA6 APCDD1 ANKS1B LAMA2 RGMA PXDN	1.49e-06	195	127	7	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	PITPNM2 HDHD3 PFAS NCAPG2 SH3TC1 CIAO3 RECQL5	1.70e-06	199	127	7	33ffea12b8228e0b5bd8942531c3b21d24224725
ToppCell	Nasal_Brush-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	XKR8 NCAPG2 LFNG ANO8 SNIP1 STRC	4.61e-06	150	127	6	d39d73a1de6a873292d48e469d9403f513045be3
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4G PLEKHH3 RGMA GUCY1A1 GUCY1B1 TPBG	1.19e-05	177	127	6	65709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4G PLEKHH3 RGMA GUCY1A1 GUCY1B1 TPBG	1.19e-05	177	127	6	8684d47a547e2a06496f15e8da0200ecddc431e0
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL NAT8L C16orf90 MPIG6B STK11IP GPR146	1.23e-05	178	127	6	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell	droplet-Marrow-nan-21m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL PODNL1 F2RL3 PGLYRP2 SH2D2A LFNG	1.48e-05	184	127	6	7e129862f8d2353387999e633725325c4d8cb42e
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APCDD1 GRIA4 LFNG PLEKHH3 GUCY1A1 GUCY1B1	1.57e-05	186	127	6	db4d9ac89cc1e55062ba888b3410b773340595dd
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	APCDD1 GRIA4 TRIL GUCY1A1 GUCY1B1 PIP5KL1	1.88e-05	192	127	6	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RASGRP4 CENPK NCAPG2 ARHGEF10L SIGLEC1 SMCR8	2.30e-05	199	127	6	c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCell	Transverse-T_cell-Tfh\|Transverse / Region, Cell class and subclass	PITPNM2 HDHD3 NCAPG2 SYNGAP1 SH3TC1 CIAO3	2.30e-05	199	127	6	cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCell	Transverse-(1)_T_cell-(16)_Tfh\|Transverse / shred on region, Cell_type, and subtype	PITPNM2 HDHD3 NCAPG2 SYNGAP1 SH3TC1 CIAO3	2.30e-05	199	127	6	aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNM2 GPR4 PLVAP F2RL3 GPR146 PXDN	2.37e-05	200	127	6	2d962c9d63e9e5f1a06870e383609672e7b1738c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	NAT8L PFAS CENPK NCAPG2 RGMA MOCS3	2.37e-05	200	127	6	691b3edf7d8449556e8bf611662eb85772959f0f
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNM2 GPR4 PLVAP F2RL3 GPR146 PXDN	2.37e-05	200	127	6	5ab588808c1fc384019413401ab4bf9bc06bf529
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	NAT8L PFAS CENPK NCAPG2 RGMA MOCS3	2.37e-05	200	127	6	36a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	NAT8L PFAS CENPK NCAPG2 RGMA MOCS3	2.37e-05	200	127	6	4e077aa7faddcebdfc54667f8b3990704441005b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	NAT8L PFAS CENPK NCAPG2 RGMA MOCS3	2.37e-05	200	127	6	d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_E\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SEMA4G GUCY1A1 GUCY1B1 GPR62 RECQL5	4.28e-05	135	127	5	35928195cf34f055b353562c96f451aef2344d64
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CA11 PLVAP MAP3K14 NCAPG2 CAPN15	6.84e-05	149	127	5	defe2e4a2f3118f8b42e99a4f2bf03e54c1b698f
ToppCell	Nasal_Brush-Epithelial-Club\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	NCAPG2 LFNG ANO8 SNIP1 STRC	7.06e-05	150	127	5	c68645ffcffe524cf1d9736cf72a15b37ed8dc3d
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A LFNG KBTBD11	9.30e-05	159	127	5	94bc6ab248a8f02ccbc0facd24e0c7e9fda687d2
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLVAP CENPK NCAPG2 TOMT PRAF2	9.86e-05	161	127	5	f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCell	Smart-seq2-spleen_(Smart-seq2)-hematologic-thrombocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPL PITPNM2 MPIG6B GUCY1A1 GUCY1B1	1.04e-04	163	127	5	ee3b11e6544d4eac38ca045179ebeace6bede237
ToppCell	Smart-seq2-spleen_(Smart-seq2)-hematologic-thrombocytic-platelet\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MPL PITPNM2 MPIG6B GUCY1A1 GUCY1B1	1.04e-04	163	127	5	c13af6895dc83b8c3bd52b8e1859818fabf85d0e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL PODNL1 F2RL3 PGLYRP2 CENPK	1.17e-04	167	127	5	41675d15919104c9e20cd97620fe636f3ff33fa9
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MAGED1 ESRRB DACT2 SEMA4G PIP5KL1	1.17e-04	167	127	5	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL PODNL1 F2RL3 PGLYRP2 CENPK	1.17e-04	167	127	5	3d5a6a4c7d037b1a6a8ec90034d88ef6d256e843
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MAGED1 ESRRB DACT2 SEMA4G PIP5KL1	1.17e-04	167	127	5	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAT8L RASGRP4 MPIG6B SLC8A3 HLTF	1.17e-04	167	127	5	0aa1973141a2437df24c9857cd50ff3dfc7673c0
ToppCell	droplet-Fat-Bat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf90 PLEKHG4 AK8 SNIP1 AP5B1	1.20e-04	168	127	5	6fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCell	droplet-Fat-Bat-18m-Myeloid-myeloid_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf90 PLEKHG4 AK8 SNIP1 AP5B1	1.20e-04	168	127	5	794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCell	droplet-Fat-Bat-18m-Myeloid\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf90 PLEKHG4 AK8 SNIP1 AP5B1	1.20e-04	168	127	5	1e23b634f96e88b976a523ca1f3fc08f6fe9b239
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL F2RL3 PGLYRP2 CENPK TM7SF2	1.31e-04	171	127	5	c60313b045cb77c0923ddb81bbd1a654aa1087c5
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|390C / Donor, Lineage, Cell class and subclass (all cells)	GPR4 F2RL3 SEMA4G GPR146 PXDN	1.34e-04	172	127	5	6f302ed795767a9636081dc64373f8f039ea16d2
ToppCell	390C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	GPR4 F2RL3 SEMA4G GPR146 PXDN	1.34e-04	172	127	5	fd8097299fc05390b30afaa9e6c80b1f607c27aa
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP AK8 ARHGAP5 AP5B1 LTN1	1.34e-04	172	127	5	7fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCell	367C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	RCE1 TLK2 LAMA2 ANO8 GUCY1A1	1.34e-04	172	127	5	fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLVAP AK8 ARHGAP5 AP5B1 LTN1	1.34e-04	172	127	5	2a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	BOC SPATA6 LFNG ARHGEF10L TPBG	1.38e-04	173	127	5	d4cbeae262abfa30d8c5452285d3261a96875610
ToppCell	droplet-Marrow-nan-24m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A LFNG KBTBD11	1.42e-04	174	127	5	955a3de6b7efc117f34c14faf8051f41454275dd
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L GPR4 PLVAP SKIDA1 GPR146	1.42e-04	174	127	5	fa6eb451555766398996bbe8f555a3f4c0f3c108
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L GPR4 PLVAP SKIDA1 GPR146	1.42e-04	174	127	5	1f5b0fa58b2a7335667357af7e50e5242cd13d7d
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L GPR4 PLVAP SKIDA1 GPR146	1.42e-04	174	127	5	ac3aee6ed49d1c421f33509e3ffc5cb17750a473
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPL NAT8L APCDD1 F2RL3 PRAF2	1.42e-04	174	127	5	eb8012823b08729b462d1e5212f4873bb6b4eb1e
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MPL NAT8L APCDD1 F2RL3 PRAF2	1.42e-04	174	127	5	32fdeeebeeeca657eac6329caad4c28ca54e4d1c
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A PIP5KL1 KBTBD11	1.46e-04	175	127	5	db977f18a71845ecb16ee3e6b3fb03dea4a1a8bc
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A PIP5KL1 KBTBD11	1.46e-04	175	127	5	7b38cbd73be26cf33393c6e6c804d62856a91ec3
ToppCell	primary_visual_cortex-Non-neuronal\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NAT8L LAMA2 CPT1A LFNG TRIL	1.50e-04	176	127	5	2c92f3f55d668cfe80051b5128160a6dc3aec4e8
ToppCell	facs-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2RL3 PGLYRP2 SH2D2A APOBR AK8	1.54e-04	177	127	5	17065d37fd41f04f67282bee00365daa185e8355
ToppCell	facs-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2RL3 PGLYRP2 SH2D2A APOBR AK8	1.54e-04	177	127	5	6e45e1a5a894ca2e4ebc5cdb17fdf79e9e188185
ToppCell	facs-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	F2RL3 PGLYRP2 SH2D2A APOBR AK8	1.54e-04	177	127	5	9ff3a77c5c62c8a950c46ca22cd7bde425b84c9a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GPR4 PLVAP ARHGAP11A CENPK NCAPG2	1.54e-04	177	127	5	73ba0f0b4b33f10e9f036d6d9befa48a1258e682
ToppCell	COVID-19-Myeloid-MoAM4\|Myeloid / Condition, Lineage and Cell class	PODNL1 APCDD1 NAP1L2 GUCY1A1 GUCY1B1	1.58e-04	178	127	5	fe0017e6a1f23dc45f644b9acacc7e8aa80d0116
ToppCell	droplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL PGLYRP2 SH2D2A GUCY1A1 KBTBD11	1.58e-04	178	127	5	8aef208b6351143562c87715bb11628880abce94
ToppCell	facs-Heart-RA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A PIP5KL1 KBTBD11	1.58e-04	178	127	5	ba6ded4455233635a11afcf6f522c786bd81b5e0
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR4 MAP3K14 STK11IP GPR146 ARHGAP5	1.62e-04	179	127	5	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	droplet-Kidney-nan-3m-Hematologic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 PODNL1 CAND2 F2RL3 PGLYRP2	1.70e-04	181	127	5	58d7e76dfaa818aeaef7f129c4472bf5b6563218
ToppCell	droplet-Kidney-nan-3m-Hematologic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 PODNL1 CAND2 F2RL3 PGLYRP2	1.70e-04	181	127	5	5d76e99bf2b5b337041efd3cd33bebbb0637b64e
ToppCell	droplet-Kidney-nan-3m-Hematologic-leukocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 PODNL1 CAND2 F2RL3 PGLYRP2	1.70e-04	181	127	5	970fc90e27236ee30190f1a02f418a378919c60b
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega\|blood / Manually curated celltypes from each tissue	F2RL3 MPIG6B SLC8A3 GUCY1A1 GUCY1B1	1.75e-04	182	127	5	3100165c5ba8c3016f9a2f7a8e4ea136750823fe
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	APCDD1 ANKS1B LAMA2 RGMA PXDN	1.75e-04	182	127	5	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Stroma____kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL CA11 TRIL GUCY1A1 GUCY1B1	1.79e-04	183	127	5	8de4b616a06be03e1cb6ae6a9ce6bf06485629d3
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SKIDA1 ZBTB9 NCAPG2 GUCY1A1 GUCY1B1	1.84e-04	184	127	5	b8ecf58b3bdb25bcba5efc2d764930bb84ab95c8
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 SH2D2A LFNG ARHGAP5 KBTBD11	1.84e-04	184	127	5	8c23945bafe8926f25836bc208115edd5214a2b0
ToppCell	facs-Liver-Non-hepatocytes-3m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 FRMD7 SH2D2A LFNG KBTBD11	1.84e-04	184	127	5	8fc047977fad38fcd26eebcc279a688efd342ed8
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SKIDA1 ZBTB9 NCAPG2 GUCY1A1 GUCY1B1	1.84e-04	184	127	5	b232a9cc1d14e1a134b037016d437b93921a4a0f
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAT8L SKIDA1 LAMA2 ADAMTS17 ADAMTS15	1.89e-04	185	127	5	355b03c7ea438681e11a2b872c798c9ea26e1486
ToppCell	356C-Endothelial_cells-Endothelial-E-\|356C / Donor, Lineage, Cell class and subclass (all cells)	GPR4 PLVAP F2RL3 GPR146 PXDN	1.93e-04	186	127	5	2e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell	356C-Endothelial_cells-Endothelial-E\|356C / Donor, Lineage, Cell class and subclass (all cells)	GPR4 PLVAP F2RL3 GPR146 PXDN	1.93e-04	186	127	5	c3449e54454009973818fc1101933c6f0168258c
ToppCell	droplet-Lung-nan-21m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PODNL1 PGLYRP2 SH2D2A KBTBD11 STRC	1.93e-04	186	127	5	8fc0487fc1b2fd403bd7c257fcabbff652f971c9
ToppCell	severe-Others\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	F2RL3 MPIG6B SLC8A3 GUCY1A1 GUCY1B1	1.93e-04	186	127	5	234a4bc7c3529daf8804f2a366887d02a47075cd
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SPATA6 APCDD1 ANKS1B LAMA2 PXDN	1.98e-04	187	127	5	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	E12.5-Mesenchymal\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BOC MAGED1 TRIL GUCY1A1 GUCY1B1	2.03e-04	188	127	5	9778dadc2bd7ded3a723e717d1c8cd3160e99c6c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	BOC LAMA2 RGMA ADAMTS15 TRAM2	2.14e-04	190	127	5	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_A_+_HSC\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL MAGED1 F2RL3 PGLYRP2 GUCY1A1	2.14e-04	190	127	5	96a9756cad5468a12591021e6d661ed269b5b3d9
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT4 F2RL3 PGLYRP2 SH2D2A GPR62	2.14e-04	190	127	5	f5a8b44d9948a16e2d5284c78d8f7ed422ac623a
ToppCell	facs-Marrow-KLS-18m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL F2RL3 RSL1D1 PFAS PGLYRP2	2.14e-04	190	127	5	11f32f46661e44770782b8ec13c00028e1dfc3cd
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LAMA2 GUCY1A1 GUCY1B1 SLC35F6 TPBG	2.14e-04	190	127	5	979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BOC LAMA2 PXDN ADAMTS15 TPBG	2.14e-04	190	127	5	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Proliferating_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	B3GNT4 F2RL3 PGLYRP2 SH2D2A GPR62	2.14e-04	190	127	5	08420f0ecd2c62e102371d16dcb8eda0d510e92a
ToppCell	facs-Marrow-KLS-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL F2RL3 RSL1D1 PFAS PGLYRP2	2.14e-04	190	127	5	20f4f6fe09345878484086047061d6f900f9d476
ToppCell	B_cell_maturation-CD34+_pre-plamsa\|B_cell_maturation / Lineage and Cell class	MAGED1 F2RL3 PXDN SH3TC1 STARD3	2.19e-04	191	127	5	4ee160a863d4fb9c4c9449633b9f337db8871992
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SPATA6 APCDD1 ANKS1B LAMA2 ADAMTS17	2.19e-04	191	127	5	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LAMA2 PLEKHH3 GUCY1A1 GUCY1B1 SLC35F6	2.19e-04	191	127	5	2ad717b59215ad8d933e9637d363b65d7298e5d4
ToppCell	facs-Marrow-KLS-3m-Hematologic-MPP_Fraction_A_+_HSC\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPL MAGED1 F2RL3 PGLYRP2 GUCY1A1	2.24e-04	192	127	5	959c28d28397bc0b9d3970d1fe3293d2750e63d4
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LAMA2 GUCY1A1 GUCY1B1 SLC35F6 TPBG	2.24e-04	192	127	5	063e119c4b58957643908f667e6cfd6f7517fd03
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TBL3 LFNG PRAF2 ALG12 SLC25A17	2.24e-04	192	127	5	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PITPNM2 GPR4 PLVAP F2RL3 PXDN	2.30e-04	193	127	5	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SPATA6 ANKS1B TRIL SLC8A3 GUCY1A1	2.35e-04	194	127	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	droplet-Bladder-nan-24m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR4 PLVAP GPR146 GUCY1A1 GUCY1B1	2.47e-04	196	127	5	9a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCell	E17.5-Mesenchymal\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MAGED1 TRIL GUCY1A1 GUCY1B1 ADAMTS17	2.47e-04	196	127	5	b4ee991445b612506372b9361ebfe72cb59b811e
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PITPNM2 GPR4 PLVAP F2RL3 GPR146	2.47e-04	196	127	5	f0b106078212be1d0938f545707a004a1e830857
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR4 LAMA2 PXDN GUCY1A1 GUCY1B1	2.47e-04	196	127	5	12d9028f90c057c6e5cff00301793fa550e86c5a
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR4 PLVAP GPR146 GUCY1A1 GUCY1B1	2.47e-04	196	127	5	04dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BOC APCDD1 LAMA2 TSKU PXDN	2.52e-04	197	127	5	3bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BOC APCDD1 LAMA2 TSKU PXDN	2.52e-04	197	127	5	17344464fdcc5ba0c03959696b97c195f11e644c
ToppCell	NS-critical-d_16-33-Epithelial-Secretory\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MAGED1 AMN TSKU PXDN TPBG	2.52e-04	197	127	5	a72047b7428c0d4aaf016c1ac23dc30919260fd8
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.56e-05	2	117	2	DOID:0110471 (implicated_via_orthology)
Disease	age of onset of childhood onset asthma	PITPNM2 MAP3K14 AP5B1 D2HGDH	5.01e-04	92	117	4	OBA_2001015
Disease	cancer antigen 125 measurement	CIAO3 D2HGDH	6.87e-04	10	117	2	EFO_0010603
Disease	von Willebrand factor measurement, coronary artery disease	MPIG6B AK8 GUCY1A1 FURIN	1.27e-03	118	117	4	EFO_0001645, EFO_0004629
Disease	Myopia	LAMA2 GRIA4	1.58e-03	15	117	2	C0027092
Disease	cataract	CPT1A PLEKHH3 PIP5KL1 HERC2	2.44e-03	141	117	4	MONDO_0005129
Disease	nicotine dependence symptom count, depressive symptom measurement	GRIA4 RGMA UBIAD1	3.33e-03	75	117	3	EFO_0007006, EFO_0009262
Disease	glioma	GRIA4 D2HGDH	3.42e-03	22	117	2	EFO_0005543
Disease	autism spectrum disorder	ESRRB PFAS TLK1 SLC8A3	3.51e-03	156	117	4	EFO_0003756
Disease	Corneal astigmatism	DACT2 SLC35F6 HERC2	3.59e-03	77	117	3	EFO_1002040
Disease	allergic disease	ZBTB9 APOBR ANAPC1 AP5B1 D2HGDH	3.72e-03	258	117	5	MONDO_0005271
Disease	Headache, type 2 diabetes mellitus	AMN TSKU	3.73e-03	23	117	2	HP_0002315, MONDO_0005148

Protein segments in the cluster

Peptide	Gene	Start	Entry
ILLQYRLRSTAHLPG	ARHGEF10L	1171	Q9HCE6
LRLSHEALRQIYLSG	CPT1A	21	P50416
RARILDTFLGLPQYH	AMN	271	Q9BXJ7
GGPLLYSHRLSELRL	CA11	121	O75493
LLHGLLLHRQLYGTR	DNHD1	4266	Q96M86
LATAARLYRHPSILN	ADAMTS15	246	Q8TE58
LLLHLPAFGRDLYLQ	ADAMTS17	81	Q8TE56
AAPGLLALYRDTHRV	ALG12	436	Q9BV10
VLQPHLYRRLGRGEL	ANO8	486	Q9HCE9
AKHARGRLVLYDRPL	RBM15	231	Q96T37
LLGHNLRTYIIPRSV	NAP1L2	391	Q9ULW6
DTLLRLRHPLGEAYA	HDHD3	16	Q9BSH5
PLYRAGHLILQDRAS	NSUN5	201	Q96P11
LHRPLLEGRLSLNYE	LTN1	966	O94822
LGLRPRHAYSILDVR	CAPN15	711	O75808
LRHLYVLAAEPRLLV	ANAPC1	1606	Q9H1A4
LETPLDLAALYGRLR	ANKS1B	161	Q7Z6G8
RPHELLNRLILAYSL	OTOP3	441	Q7RTS5
GRREVQALLAHLPRY	PIP5KL1	156	Q5T9C9
VAALGLARYRLIVHP	GPR62	106	Q9BZJ7
RINPGLEYRQHLLLR	KMT2C	4131	Q8NEZ4
NLRALLRLLASYPHT	LFNG	206	Q8NES3
RHPLLGDLRKLLTYE	MAGED1	596	Q9Y5V3
ERNLGLLLGLHASYL	HERC2	1306	O95714
PGHLREELTRYLFTL	FRMD7	86	Q6ZUT3
EIPYLLDLHLFLGRS	DDX54	446	Q8TDD1
PSLRGALLSLLDHYE	GRIA4	136	P48058
LEHPQRRPLLAGYAL	RCE1	276	Q9Y256
PRDLDQAHLLNRLGY	AK8	356	Q96MA6
NRTLGSLRNILYLLH	SLC25A17	241	O43808
NLYHPLGSELASIRR	PLVAP	256	Q9BX97
LHTQARSPEGLRLIY	FAT2	2191	Q9NYQ8
GLLRPDYALLGHRQL	PGLYRP2	511	Q96PD5
NLSHGALRFIRLEPL	PRAMEF18	326	Q5VWM3
DGRLHLPKLNNLYLR	RASGRP4	371	Q8TDF6
APLAALRRLYLHNNS	LRRC24	71	Q50LG9
YLASRIPVQALLHLR	GNL1	446	P36915
YAILLNRGRLEVHLS	LAMA2	2586	P24043
RGLYLSDIPLHDATR	GUCY1B1	336	Q02153
SPRHYLEELLAGLRQ	AP5B1	436	Q2VPB7
RVHYPSALGRLAIRL	PITPNM2	461	Q9BZ72
GLSALLLRYFLEHLR	MROH1	941	Q8NDA8
RFLAPYGRQDLHLRI	GTPBP8	56	Q8N3Z3
YLAPRHSLLELERLL	NUDT13	66	Q86X67
HVLLLSRSAIYLGRP	GPR4	241	P46093
FHLLLAARSGPARLL	TM7SF2	31	O76062
ALALPPRIAYHLRGQ	F2RL3	126	Q96RI0
SLDRYLALVHPLRAR	F2RL3	171	Q96RI0
RLHGARGLRYLLLQH	PODNL1	306	Q6PEZ8
GALRPLRGLHTLHLY	PODNL1	331	Q6PEZ8
QHRLTLTRLDPGSLY	BOC	531	Q9BWV1
GPARARAYIDRLLHL	DACT2	326	Q5SW24
LYRGLLLVHRLSPLE	B3GNT4	341	Q9C0J1
RGVPVYLLLAQEHLR	FAM83C	196	Q9BQN1
LTLSYNRRGDLAIHL	FURIN	491	P09958
PYVELLLRNGIALRH	CENPK	241	Q9BS16
RLLLRYLFPALLLHG	APCDD1	6	Q8J025
NFRLRHLRGLGLYLE	C16orf90	56	A8MZG2
HYADVLGLLLRLRQI	HLTF	701	Q14527
HSRLAGLLELYRAIL	ESRRB	311	O95718
ALLSLDHYIERALPR	GPR146	121	Q96CH1
AEPRRQYLLLHSLRE	CAND2	906	O75155
LRYSRQLVLPELGVH	MOCS3	61	O95396
LYDIVTDLRARLGPH	D2HGDH	411	Q8N465
QLRFLLSLPEHRGDA	PSMD6	21	Q15008
LGQALEGLEYLHSRR	MAP3K14	496	Q99558
LAYNLLEGHRELSPL	STK11IP	261	Q8N1F8
LVRLALLQHLRAFYG	ARHGAP11A	6	Q6P4F7
LRIYPHGLVLLDLQS	SMS	61	P52788
YLLGRHRRIADIPID	SNIP1	281	Q8TAD8
RSLIDLRRAPHFYIG	TMC3	961	Q7Z5M5
ALIYLRNPILRHTSG	PLEKHH3	226	Q7Z736
ARLQDLLLHYTAHPL	SH2D2A	161	Q9NP31
LYRLRALGERNHLDL	TMEM120B	241	A0PK00
SLNLHLYRDPALLGL	PLEKHG4	1111	Q58EX7
GHLLRYGEPTLRRAV	PSMD2	676	Q13200
NLSHGTLRFIRLEPL	PRAMEF19	326	Q5SWL8
ARRRQLLLTEGPHLY	PDPK1	471	O15530
YADLDHLALSRPRRL	MPIG6B	211	O95866
LLLYRHRQGIDLSTL	GPAM	491	Q9HCL2
HAGARRLLLLPRSYK	SKIDA1	286	Q1XH10
LLQTLHLGTGRRVLY	TENM1	1956	Q9UKZ4
PFLERLLLLHRDSGA	SH3TC1	686	Q8TE82
LLQLDHGRLRLYHDS	ARHGAP5	576	Q13017
RGYSLLIRGLIHSDR	PRORP	211	O15091
LHLYERTRDLPGRAA	RGMA	411	Q96B86
LNRRHAELAPLAAIY	MTRF1	106	O75570
ARSQLRLLALDGHLY	KBTBD11	401	O94819
HYLLRLLTFLLGPGA	STRC	621	Q7RTU9
LNTDLKGRLPRYLIH	STARD3	406	Q14849
LYRGTLVPRLADHRT	SMCR8	821	Q8TEV9
PTLNDRYLLLHLLGR	TLK2	456	Q86UE8
LYLPGLHQALRGALD	APOBR	6	Q0VD83
RPSRELLQHVERLYG	CIAO3	411	Q9H6Q4
LLEQLLPALRYSLHD	NCAPG2	456	Q86XI2
GLRLLYSVQRPLHEF	NCAPG2	976	Q86XI2
PDYLRLGALRSRLGH	RECQL5	171	O94762
LLSLRALHLRGYVFQ	TLR8	366	Q9NR97
TLNERYLLLHLLGRG	TLK1	451	Q9UKI8
GRPLLLKRNIRYTHL	SEMA4G	416	Q9NTN9
GRESLYLQLHGDLVR	PHLPP2	81	Q6ZVD8
YLQLHGDLVRRLEPT	PHLPP2	86	Q6ZVD8
HLDLRGNRLKTLPYE	SLITRK1	181	Q96PX8
NLPAVRALRLHLYRD	SYNGAP1	316	Q96PV0
ALPRRNHLYLGETVR	TRAPPC14	31	Q8WVR3
LALAGYVRPLHTLLS	PRAF2	56	O60831
IRRLLPSLIGRHFYQ	RSL1D1	161	O76021
YLRALGLAISLDRPH	TBL3	666	Q12788
YLRDLQLLEAHALLP	TOMT	221	Q8WZ04
HIAGAYLLNLSRLGL	TRAM2	201	Q15035
GLLLRHNLSGRYESR	PFAS	1191	O15067
LLYLHLESNRIRFLG	TRIL	181	Q7L0X0
RFGHTLVNPLLYRLD	PXDN	1071	Q92626
APRNLRLTYLLESHG	SIGLEC1	1171	Q9BZZ2
SLPDLHRVLGQYLRD	MPL	531	P40238
YHRALLQLRGLDPSL	TTC9C	31	Q8N5M4
LAYRSHGVLDPRLLV	UBIAD1	71	Q9Y5Z9
LLIGTALYNGLHRPL	SLC35F6	326	Q8N357
ALYNGLHRPLLGRLS	SLC35F6	331	Q8N357
QLIYSGRLRLPLDAL	ZBTB9	101	Q96C00
LRSHGYPREALRLAI	ZSWIM6	576	Q9HCJ5
HYLLRLLTFLLGPGA	STRCP1	621	A6NGW2
GLRRLELASNHFLYL	TPBG	211	Q13641
LELLNREPGLSYSHL	VRTN	271	Q9H8Y1
RLRYLESLDLSHNGL	TSKU	106	Q8WUA8
EDTRRRLAHLNLGPY	SPATA6	231	Q9NWH7
SILHRTDPYLGLLLQ	ZP4	351	Q12836
LRDYLPRHSIGLAQL	TYK2	986	P29597
PRRCLALLHLLQLGY	XKR8	81	Q9H6D3
RGLYLSDIPIHNALR	GUCY1A1	396	Q02108
ISVLLYRRRPHLGGE	SLC8A3	876	P57103
LRQHPRAQLLYALLA	NAT8L	111	Q8N9F0