Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1	3.74e-05	473	54	8	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	WSB1 RAG1 ITCH WWP1 WWP2 HACE1 CCAR1	6.14e-05	372	54	7	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1	6.53e-05	512	54	8	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1	8.53e-05	532	54	8	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	WSB1 RAG1 ITCH WWP1 WWP2 HACE1 CCAR1	9.37e-05	398	54	7	GO:0061659
GeneOntologyMolecularFunction	acyltransferase activity	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1	1.06e-03	775	54	8	GO:0016746
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 HACE1 CCAR1 XPO1 KLHDC10 KLHL22	5.38e-06	640	54	10	GO:0006511
GeneOntologyBiologicalProcess	modification-dependent protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 HACE1 CCAR1 XPO1 KLHDC10 KLHL22	6.25e-06	651	54	10	GO:0019941
GeneOntologyBiologicalProcess	modification-dependent macromolecule catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 HACE1 CCAR1 XPO1 KLHDC10 KLHL22	6.69e-06	656	54	10	GO:0043632
GeneOntologyBiologicalProcess	proteasome-mediated ubiquitin-dependent protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 XPO1 KLHDC10 KLHL22	1.36e-05	424	54	8	GO:0043161
GeneOntologyBiologicalProcess	protein ubiquitination	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1 KLHDC10 KLHL22	4.16e-05	811	54	10	GO:0016567
GeneOntologyBiologicalProcess	proteolysis involved in protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 HACE1 CCAR1 XPO1 KLHDC10 KLHL22	4.20e-05	812	54	10	GO:0051603
GeneOntologyBiologicalProcess	protein autoubiquitination	RAG1 ERCC8 ITCH WWP2	5.18e-05	78	54	4	GO:0051865
GeneOntologyBiologicalProcess	post-translational protein modification	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1 KLHDC10 STT3A KLHL22	8.80e-05	1074	54	11	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1 KLHDC10 KLHL22	9.31e-05	893	54	10	GO:0032446
GeneOntologyBiologicalProcess	proteasomal protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 XPO1 KLHDC10 KLHL22	1.06e-04	567	54	8	GO:0010498
GeneOntologyBiologicalProcess	protein catabolic process	ERCC8 ITCH CSNK2A1 WWP1 WWP2 HACE1 CCAR1 XPO1 KLHDC10 CSNK2A3 KLHL22	1.23e-04	1115	54	11	GO:0030163
GeneOntologyBiologicalProcess	negative regulation of peptidyl-cysteine S-nitrosylation	OXR1 NCOA7	1.86e-04	8	54	2	GO:1902083
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	WSB1 RAG1 ERCC8 ITCH WWP1 WWP2 HACE1 CCAR1 KLHDC10 KLHL22	2.52e-04	1009	54	10	GO:0070647
GeneOntologyBiologicalProcess	cellular response to hydroperoxide	OXR1 SIN3A	2.99e-04	10	54	2	GO:0071447
GeneOntologyBiologicalProcess	regulation of peptidyl-cysteine S-nitrosylation	OXR1 NCOA7	3.64e-04	11	54	2	GO:2000169
GeneOntologyBiologicalProcess	negative regulation of cellular response to oxidative stress	OXR1 NCOA7	4.37e-04	12	54	2	GO:1900408
GeneOntologyCellularComponent	transferase complex	ERCC8 ITCH CBX5 CSNK2A1 ZC3H13 WWP1 WWP2 ACTBL2 KLHDC10 CSNK2A3 STT3A KLHL22	5.98e-06	963	55	12	GO:1990234
GeneOntologyCellularComponent	intracellular protein-containing complex	RAG1 ERCC8 EPRS1 ITCH CSNK2A1 WWP1 WWP2 ACTBL2 KLHDC10 CSNK2A3 KLHL22	3.79e-05	972	55	11	GO:0140535
GeneOntologyCellularComponent	protein kinase CK2 complex	CSNK2A1 CSNK2A3	4.06e-05	4	55	2	GO:0005956
GeneOntologyCellularComponent	histone deacetylase complex	CBX5 CSNK2A1 CHD3 SIN3A	7.41e-05	85	55	4	GO:0000118
GeneOntologyCellularComponent	organelle envelope lumen	TRAP1 SUOX CCAR1 BCHE	1.51e-04	102	55	4	GO:0031970
GeneOntologyCellularComponent	ubiquitin ligase complex	ERCC8 ITCH WWP1 WWP2 KLHDC10 KLHL22	3.16e-04	352	55	6	GO:0000151
GeneOntologyCellularComponent	nuclear envelope lumen	CCAR1 BCHE	6.06e-04	14	55	2	GO:0005641
GeneOntologyCellularComponent	kinetochore	CBX5 SMARCD2 SIN3A XPO1	1.31e-03	181	55	4	GO:0000776
GeneOntologyCellularComponent	Sin3-type complex	CSNK2A1 SIN3A	1.52e-03	22	55	2	GO:0070822
GeneOntologyCellularComponent	condensed chromosome, centromeric region	CBX5 SMARCD2 SIN3A XPO1	1.66e-03	193	55	4	GO:0000779
GeneOntologyCellularComponent	nuclear body	PTPRH CBX5 CSNK2A1 ZC3H13 HACE1 AIPL1 CHD3 XPO1	2.36e-03	903	55	8	GO:0016604
Domain	HECT	ITCH WWP1 WWP2 HACE1	1.04e-06	27	54	4	PF00632
Domain	HECTc	ITCH WWP1 WWP2 HACE1	1.04e-06	27	54	4	SM00119
Domain	HECT_dom	ITCH WWP1 WWP2 HACE1	1.04e-06	27	54	4	IPR000569
Domain	HECT	ITCH WWP1 WWP2 HACE1	1.04e-06	27	54	4	PS50237
Domain	E3_ub_ligase_SMURF1	WWP1 WWP2	8.21e-06	2	54	2	IPR024928
Domain	TLDc	OXR1 NCOA7	8.16e-05	5	54	2	SM00584
Domain	LysM_dom	OXR1 NCOA7	1.22e-04	6	54	2	IPR018392
Domain	TLDc_dom	OXR1 NCOA7	1.22e-04	6	54	2	IPR006571
Domain	LYSM	OXR1 NCOA7	1.22e-04	6	54	2	PS51782
Domain	LysM	OXR1 NCOA7	1.22e-04	6	54	2	PF01476
Domain	-	OXR1 NCOA7	1.22e-04	6	54	2	3.10.350.10
Domain	TLD	OXR1 NCOA7	1.22e-04	6	54	2	PF07534
Domain	LysM	OXR1 NCOA7	1.22e-04	6	54	2	SM00257
Domain	WW	ITCH WWP1 WWP2	3.39e-04	47	54	3	PF00397
Domain	WW	ITCH WWP1 WWP2	3.60e-04	48	54	3	SM00456
Domain	WW_DOMAIN_2	ITCH WWP1 WWP2	4.31e-04	51	54	3	PS50020
Domain	WW_DOMAIN_1	ITCH WWP1 WWP2	4.31e-04	51	54	3	PS01159
Domain	aa-tRNA-synt_IIb	EPRS1 EIF2AK4	4.44e-04	11	54	2	IPR002314
Domain	tRNA-synt_2b	EPRS1 EIF2AK4	4.44e-04	11	54	2	PF00587
Domain	-	EPRS1 EIF2AK4	4.44e-04	11	54	2	3.40.50.800
Domain	WW_dom	ITCH WWP1 WWP2	4.57e-04	52	54	3	IPR001202
Domain	C2	ITCH WWP1 WWP2 PLCE1	5.57e-04	131	54	4	PF00168
Domain	C2	ITCH WWP1 WWP2 PLCE1	6.59e-04	137	54	4	SM00239
Domain	Anticodon-bd	EPRS1 EIF2AK4	7.30e-04	14	54	2	IPR004154
Domain	C2	ITCH WWP1 WWP2 PLCE1	7.54e-04	142	54	4	PS50004
Domain	-	ITCH WWP1 WWP2 PLCE1	8.80e-04	148	54	4	2.60.40.150
Domain	Chromodomain_CS	CBX5 CHD3	1.22e-03	18	54	2	IPR023779
Domain	aa-tRNA-synth_II	EPRS1 EIF2AK4	1.22e-03	18	54	2	IPR006195
Domain	AA_TRNA_LIGASE_II	EPRS1 EIF2AK4	1.22e-03	18	54	2	PS50862
Domain	C2_dom	ITCH WWP1 WWP2 PLCE1	1.29e-03	164	54	4	IPR000008
Domain	GRAM	OXR1 NCOA7	1.83e-03	22	54	2	PF02893
Domain	GRAM	OXR1 NCOA7	1.83e-03	22	54	2	IPR004182
Domain	Chromo_domain	CBX5 CHD3	2.17e-03	24	54	2	IPR023780
Domain	Chromo	CBX5 CHD3	2.55e-03	26	54	2	PF00385
Domain	CHROMO_1	CBX5 CHD3	2.96e-03	28	54	2	PS00598
Domain	CHROMO_2	CBX5 CHD3	2.96e-03	28	54	2	PS50013
Domain	Chromodomain-like	CBX5 CHD3	3.85e-03	32	54	2	IPR016197
Domain	Chromo/shadow_dom	CBX5 CHD3	4.09e-03	33	54	2	IPR000953
Domain	CHROMO	CBX5 CHD3	4.09e-03	33	54	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	DHX16 CHD3	4.59e-03	35	54	2	IPR002464
Domain	DEAH_ATP_HELICASE	DHX16 CHD3	5.40e-03	38	54	2	PS00690
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	ERCC8 ITCH WWP1 WWP2	1.97e-09	11	56	4	17996703
Pubmed	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.	ITCH WWP1 WWP2	3.95e-09	3	56	3	12450395
Pubmed	Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.	ITCH WWP1 WWP2	1.58e-08	4	56	3	26701932
Pubmed	A Tunable Brake for HECT Ubiquitin Ligases.	ITCH WWP1 WWP2	3.94e-08	5	56	3	28475870
Pubmed	Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.	ITCH WWP1 WWP2	7.88e-08	6	56	3	9647693
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	ITCH WWP1 WWP2 HACE1	8.77e-08	26	56	4	26949039
Pubmed	Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.	ITCH WWP1 WWP2	1.38e-07	7	56	3	31845480
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	ITCH WWP1 WWP2	2.20e-07	8	56	3	19307600
Pubmed	A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.	TRAP1 ITCH WWP1 WWP2 HACE1	3.19e-07	88	56	5	27182664
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	ITCH WWP1 WWP2	4.71e-07	10	56	3	25092867
Pubmed	Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.	ITCH WWP1 WWP2	6.46e-07	11	56	3	21191027
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	ITCH WWP1 WWP2	6.46e-07	11	56	3	22773947
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	ITCH WWP1 WWP2	6.46e-07	11	56	3	25963657
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DCHS2 CSNK2A1 CCAR1 AK9 EIF2AK4 XPO1 LCP2 CSNK2A3	1.28e-06	497	56	8	36774506
Pubmed	Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin.	CSNK2A1 CHD3 SIN3A	1.42e-06	14	56	3	17827154
Pubmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.	ITCH WWP1 WWP2	1.42e-06	14	56	3	31015455
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	ITCH WWP1 WWP2	2.18e-06	16	56	3	25723849
Pubmed	Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	14646071
Pubmed	Assignment of casein kinase 2 alpha sequences to two different human chromosomes.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	1577469
Pubmed	Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing.	RAG1 EIF2AK4	2.55e-06	2	56	2	27880901
Pubmed	Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	12860116
Pubmed	Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform.	OXR1 NCOA7	2.55e-06	2	56	2	18299425
Pubmed	Molecular cloning of the human casein kinase II alpha subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	2752008
Pubmed	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.	CSNK2A1 CSNK2A3	2.55e-06	2	56	2	8420794
Pubmed	WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism.	WWP1 WWP2	2.55e-06	2	56	2	31965758
Pubmed	The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins.	OXR1 NCOA7	2.55e-06	2	56	2	17391516
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	ITCH WWP1 WWP2	2.65e-06	17	56	3	28292929
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	ITCH WWP1 WWP2	3.76e-06	19	56	3	21572392
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	ITCH CSNK2A1 WWP1 WWP2	3.79e-06	65	56	4	29378950
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 EPRS1 SEC16B CSNK2A1 ZC3H13 CCAR1 CHD3 SIN3A XPO1	3.80e-06	774	56	9	15302935
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	ITCH WWP1 WWP2	5.15e-06	21	56	3	37005481
Pubmed	ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.	ITCH WWP1 WWP2	5.15e-06	21	56	3	29416926
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CBX5 CSNK2A1 SMARCD2 CHD3 SIN3A	5.58e-06	157	56	5	30186101
Pubmed	USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.	ITCH WWP1 WWP2	5.96e-06	22	56	3	24850914
Pubmed	Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.	HLA-DMA LCP2	7.63e-06	3	56	2	22623329
Pubmed	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	15684395
Pubmed	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	2174700
Pubmed	mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival.	CBX5 SIN3A	7.63e-06	3	56	2	15998811
Pubmed	Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	1766873
Pubmed	The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla.	RAG1 HLA-DMA	7.63e-06	3	56	2	19843939
Pubmed	Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.	ITCH WWP2	7.63e-06	3	56	2	19997087
Pubmed	NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.	ITCH CSNK2A1	7.63e-06	3	56	2	17437719
Pubmed	Mechanism and function of Vav1 localisation in TCR signalling.	RAG1 LCP2	7.63e-06	3	56	2	22956543
Pubmed	Crystallization and preliminary characterization of crystals of human protein kinase CK2.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	11092945
Pubmed	The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.	ITCH WWP2	7.63e-06	3	56	2	29925997
Pubmed	Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	12102635
Pubmed	Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression.	XPO1 MAPK6	7.63e-06	3	56	2	12915405
Pubmed	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	CSNK2A1 CSNK2A3	7.63e-06	3	56	2	20625391
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 EPRS1 CCAR1 PYGB CHD3 EIF2AK4 SIN3A PLCE1	9.19e-06	650	56	8	38777146
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DHX16 EPRS1 SEC16B TRAP1 MRPS18B CSNK2A1 WWP2 CCAR1 SMARCD2 CHD3 EIF2AK4	9.99e-06	1371	56	11	36244648
Pubmed	Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.	ITCH WWP1	1.52e-05	4	56	2	19580544
Pubmed	Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.	ITCH WWP2	1.52e-05	4	56	2	20522958
Pubmed	T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.	RAG1 LCP2	1.52e-05	4	56	2	14624253
Pubmed	Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production.	RAG1 LCP2	1.52e-05	4	56	2	20029045
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	ITCH WWP1	1.52e-05	4	56	2	27466427
Pubmed	Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.	RAG1 ITCH	1.52e-05	4	56	2	27322655
Pubmed	Itch expression by Treg cells controls Th2 inflammatory responses.	RAG1 ITCH	1.52e-05	4	56	2	24135136
Pubmed	Defining the membrane proteome of NK cells.	EPRS1 TRAP1 ITCH GANAB HLA-DMA PIGS WWP2 PYGB XPO1 STT3A	1.53e-05	1168	56	10	19946888
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	WSB1 RAG1 ERCC8 SIN3A XPO1	1.76e-05	199	56	5	36688959
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	DHX16 EPRS1 ITCH GANAB ACTBL2 CCAR1	2.48e-05	360	56	6	33111431
Pubmed	A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis.	WWP1 WWP2	2.54e-05	5	56	2	10903445
Pubmed	Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol.	CSNK2A1 XPO1	2.54e-05	5	56	2	20026644
Pubmed	Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.	RAG1 CSNK2A1	2.54e-05	5	56	2	28468969
Pubmed	The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.	GANAB CSNK2A1	2.54e-05	5	56	2	24486797
Pubmed	Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140.	WWP1 WWP2	2.54e-05	5	56	2	30392800
Pubmed	The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.	OXR1 NCOA7	2.54e-05	5	56	2	26668325
Pubmed	Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.	WWP1 WWP2	2.54e-05	5	56	2	19366705
Pubmed	Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17.	CSNK2A1 XPO1	2.54e-05	5	56	2	16895915
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	WWP1 WWP2	2.54e-05	5	56	2	33762578
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX16 EPRS1 ITCH MRPS18B CSNK2A1 ZC3H13 ACTBL2 SMARCD2 XPO1 STT3A	2.88e-05	1257	56	10	36526897
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 CBX5 CSNK2A1 CCAR1 PYGB SMARCD2 CHD3 SIN3A XPO1	3.25e-05	1014	56	9	32416067
Pubmed	Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.	EPRS1 TRAP1 XPO1 STT3A	3.41e-05	113	56	4	30352685
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX16 EPRS1 TRAP1 GANAB CBX5 CSNK2A1 ACTBL2 CHD3 XPO1	3.51e-05	1024	56	9	24711643
Pubmed	N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.	ITCH WWP2	3.80e-05	6	56	2	15252135
Pubmed	Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint.	RAG1 LCP2	3.80e-05	6	56	2	16456545
Pubmed	Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases.	CBX5 SIN3A	3.80e-05	6	56	2	22318730
Pubmed	The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.	CBX5 CHD3	3.80e-05	6	56	2	24018422
Pubmed	Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.	ITCH WWP2	3.80e-05	6	56	2	37156795
Pubmed	Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production.	RAG1 ITCH	3.80e-05	6	56	2	23851689
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	ITCH WWP2	3.80e-05	6	56	2	11748237
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	EPRS1 GANAB SMARCD2 XPO1 STT3A	4.05e-05	237	56	5	29564676
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX16 EPRS1 TRAP1 GANAB CBX5 CSNK2A1 ZC3H13 CCAR1 SMARCD2 STT3A	4.29e-05	1318	56	10	30463901
Pubmed	Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.	ITCH WWP1 WWP2	4.34e-05	42	56	3	27578003
Pubmed	The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20.	RAG1 ITCH	5.32e-05	7	56	2	18246070
Pubmed	Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.	CSNK2A1 SIN3A	5.32e-05	7	56	2	11602581
Pubmed	Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.	ITCH WWP2	5.32e-05	7	56	2	11046148
Pubmed	Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.	ITCH WWP2	5.32e-05	7	56	2	23644597
Pubmed	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.	CSNK2A1 CSNK2A3	5.32e-05	7	56	2	11239457
Pubmed	Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation.	CBX5 SIN3A	5.32e-05	7	56	2	22615490
Pubmed	Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.	CSNK2A1 SIN3A	5.32e-05	7	56	2	22716292
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	EPRS1 TRAP1 GANAB CSNK2A1 XPO1	6.06e-05	258	56	5	21081666
Pubmed	Regulation of histone deacetylase 2 by protein kinase CK2.	CSNK2A1 SIN3A	7.09e-05	8	56	2	12082111
Pubmed	The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.	ITCH WWP2	7.09e-05	8	56	2	11244092
Pubmed	Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.	ITCH WWP2	7.09e-05	8	56	2	17719543
Pubmed	Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.	ITCH WWP2	7.09e-05	8	56	2	31578285
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	CSNK2A1 CSNK2A3	7.09e-05	8	56	2	12393879
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CBX5 CSNK2A1 SMARCD2 CHD3 SIN3A	7.25e-05	268	56	5	33640491
Pubmed	Network organization of the human autophagy system.	RAB3GAP1 GANAB CCAR1 NCOA7 XPO1 KLHDC10	7.26e-05	437	56	6	20562859
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	EPRS1 ITCH GANAB PYGB XPO1 KLHDC10 KLHL22	7.85e-05	647	56	7	26618866
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 GANAB CSNK2A1 ZC3H13 CCAR1 PYGB XPO1	8.32e-05	653	56	7	22586326
Interaction	TP73 interactions	ITCH CSNK2A1 WWP1 WWP2 SMARCD2 CHD3 XPO1	3.27e-07	169	54	7	int:TP73
Interaction	CT45A3 interactions	CSNK2A1 WWP2 CSNK2A3	1.51e-06	9	54	3	int:CT45A3
Interaction	RBM17 interactions	TRAP1 CSNK2A1 WWP2 ACTBL2 CCAR1 CHD3 XPO1	1.81e-06	218	54	7	int:RBM17
Interaction	CDC34 interactions	RAG1 EPRS1 ITCH GANAB WWP2 SMARCD2 XPO1 STT3A	2.45e-06	328	54	8	int:CDC34
Interaction	WBP1L interactions	ITCH WWP1 WWP2	3.93e-06	12	54	3	int:WBP1L
Interaction	TMEM255A interactions	ITCH WWP1 WWP2	1.20e-05	17	54	3	int:TMEM255A
Interaction	DDB1 interactions	WDR19 WSB1 RAG1 ERCC8 CBX5 CSNK2A1 ZC3H13 WWP1 CCAR1 SIN3A	1.39e-05	697	54	10	int:DDB1
Interaction	SMAD6 interactions	ITCH WWP1 WWP2 MAPK6	1.52e-05	56	54	4	int:SMAD6
Interaction	CCT6A interactions	ERCC8 EPRS1 ITCH GANAB CSNK2A1 ACTBL2 LOXL4 MAPK6 MMACHC	1.86e-05	570	54	9	int:CCT6A
Interaction	GPN1 interactions	CSNK2A1 WWP1 WWP2 XPO1 MAPK6	1.94e-05	123	54	5	int:GPN1
Interaction	UBE2L3 interactions	ITCH WWP1 WWP2 HACE1 MAPK6 MMACHC	2.08e-05	211	54	6	int:UBE2L3
Interaction	BRAF interactions	EPRS1 RAB3GAP1 TRAP1 ITCH WWP1 WWP2	2.14e-05	212	54	6	int:BRAF
Interaction	SCNN1A interactions	ITCH CSNK2A1 WWP1 WWP2	2.60e-05	64	54	4	int:SCNN1A
Interaction	CCT3 interactions	ERCC8 ITCH GANAB CSNK2A1 WWP2 ACTBL2 LOXL4 MAPK6 MMACHC	2.93e-05	604	54	9	int:CCT3
Interaction	ARRDC1 interactions	ITCH WWP1 WWP2 XPO1	3.30e-05	68	54	4	int:ARRDC1
Interaction	URI1 interactions	ITCH WWP1 WWP2 XPO1 PLCE1	4.01e-05	143	54	5	int:URI1
Interaction	EIF3L interactions	ERCC8 CSNK2A1 WWP2 CHD3 XPO1 CSNK2A3	4.70e-05	244	54	6	int:EIF3L
Interaction	ERH interactions	CBX5 CSNK2A1 WWP1 WWP2 CHD3 CSNK2A3	4.81e-05	245	54	6	int:ERH
Interaction	BID interactions	EPRS1 ITCH CBX5 CSNK2A1 CHD3	4.88e-05	149	54	5	int:BID
Interaction	DVL1 interactions	ITCH CSNK2A1 WWP1 WWP2 XPO1	5.20e-05	151	54	5	int:DVL1
Interaction	CD274 interactions	EPRS1 ITCH GANAB CSNK2A1 XPO1 CSNK2A3 STT3A	5.51e-05	369	54	7	int:CD274
Interaction	CCT2 interactions	ERCC8 GANAB CBX5 CSNK2A1 WWP2 ACTBL2 LOXL4 MAPK6 MMACHC	6.26e-05	666	54	9	int:CCT2
Interaction	FBXL15 interactions	ITCH WWP1 WWP2	6.32e-05	29	54	3	int:FBXL15
Interaction	KPNA2 interactions	RAG1 ITCH GANAB CBX5 WWP2 SMARCD2 CHD3 XPO1	6.73e-05	519	54	8	int:KPNA2
Interaction	EIF3C interactions	CSNK2A1 WWP2 CHD3 XPO1 MAPK6 CSNK2A3	7.13e-05	263	54	6	int:EIF3C
Interaction	TMEM41B interactions	EPRS1 TRAP1 XPO1 MAPK6 STT3A	7.26e-05	162	54	5	int:TMEM41B
Interaction	CCT5 interactions	ERCC8 EPRS1 GANAB CSNK2A1 ACTBL2 LOXL4 XPO1 MAPK6	7.29e-05	525	54	8	int:CCT5
Interaction	CPSF6 interactions	DHX16 TRAP1 ITCH CSNK2A1 WWP1 WWP2 CCAR1 XPO1	7.39e-05	526	54	8	int:CPSF6
Interaction	POLR2A interactions	ERCC8 ITCH CSNK2A1 ZC3H13 WWP1 WWP2 XPO1 MAPK6	8.43e-05	536	54	8	int:POLR2A
Interaction	FBXO22 interactions	DCHS2 CSNK2A1 CCAR1 AK9 EIF2AK4 XPO1 LCP2 CSNK2A3	8.87e-05	540	54	8	int:FBXO22
Interaction	HSP90AA1 interactions	RAG1 EPRS1 CSNK2A1 WWP1 WWP2 AIPL1 CCAR1 CHD3 SIN3A XPO1 KLHL22 PLCE1	1.02e-04	1263	54	12	int:HSP90AA1
Interaction	LIN37 interactions	PYGB CHD3 SIN3A XPO1	1.13e-04	93	54	4	int:LIN37
Interaction	SMARCE1 interactions	ITCH WWP2 SMARCD2 CHD3 SIN3A XPO1	1.15e-04	287	54	6	int:SMARCE1
Interaction	RBBP5 interactions	RAB3GAP1 CSNK2A1 ZC3H13 SMARCD2 CHD3 SIN3A	1.15e-04	287	54	6	int:RBBP5
Interaction	GPATCH2 interactions	CSNK2A1 XPO1 CSNK2A3	1.22e-04	36	54	3	int:GPATCH2
Interaction	ERBB4 interactions	ITCH PTPRH WWP1 XPO1 LCP2	1.32e-04	184	54	5	int:ERBB4
Interaction	EIF3F interactions	SUOX CSNK2A1 WWP2 CHD3 EIF2AK4 CSNK2A3	1.36e-04	296	54	6	int:EIF3F
Interaction	LDLRAD3 interactions	ITCH WWP1	1.47e-04	7	54	2	int:LDLRAD3
Interaction	HDAC5 interactions	EPRS1 TRAP1 GANAB CBX5 CSNK2A1 SIN3A XPO1	1.47e-04	432	54	7	int:HDAC5
Interaction	ABRAXAS2 interactions	WWP1 WWP2 LOXL4 XPO1	1.49e-04	100	54	4	int:ABRAXAS2
Interaction	SPART interactions	ITCH WWP1 WWP2 MAPK6	1.67e-04	103	54	4	int:SPART
Interaction	AUTS2 interactions	CSNK2A1 MAPK6 CSNK2A3	1.67e-04	40	54	3	int:AUTS2
Interaction	H2AX interactions	TRAP1 GANAB CBX5 MRPS18B CSNK2A1 SMARCD2 SIN3A CSNK2A3	1.69e-04	593	54	8	int:H2AX
Interaction	RIPK1 interactions	ITCH CBX5 CSNK2A1 XPO1 CSNK2A3	1.86e-04	198	54	5	int:RIPK1
Interaction	WBP1 interactions	ITCH WWP1 WWP2	1.94e-04	42	54	3	int:WBP1
Interaction	UBE2D2 interactions	WSB1 RAG1 ITCH WWP1 WWP2 HACE1	2.01e-04	318	54	6	int:UBE2D2
Interaction	DEK interactions	DHX16 GANAB CSNK2A1 XPO1 CSNK2A3	2.39e-04	209	54	5	int:DEK
Interaction	F2RL3 interactions	CSNK2A1 CSNK2A3	2.51e-04	9	54	2	int:F2RL3
Interaction	TXNIP interactions	ITCH CSNK2A1 WWP1 WWP2 XPO1	2.56e-04	212	54	5	int:TXNIP
Interaction	WASL interactions	ITCH WWP1 ACTBL2 BCHE	2.73e-04	117	54	4	int:WASL
Interaction	HNRNPD interactions	ERCC8 EPRS1 ITCH WWP2 PYGB SMARCD2 CHD3 MAPK6	2.78e-04	638	54	8	int:HNRNPD
Interaction	CPSF7 interactions	DHX16 ITCH CSNK2A1 WWP1 WWP2 BCHE	2.79e-04	338	54	6	int:CPSF7
Interaction	SKIL interactions	SMUG1 WWP1 CHD3 SIN3A	2.91e-04	119	54	4	int:SKIL
Interaction	NMD3 interactions	EPRS1 CSNK2A1 WWP2 XPO1	3.00e-04	120	54	4	int:NMD3
Interaction	SOX2 interactions	EPRS1 TRAP1 ITCH CBX5 MRPS18B WWP2 ACTBL2 SMARCD2 CHD3 SIN3A XPO1 KLHL22	3.10e-04	1422	54	12	int:SOX2
Interaction	EFCAB14 interactions	CSNK2A1 CSNK2A3	3.13e-04	10	54	2	int:EFCAB14
Interaction	SCRT1 interactions	WWP1 KLHDC10	3.13e-04	10	54	2	int:SCRT1
Interaction	SMARCA2 interactions	CBX5 WWP2 ACTBL2 SMARCD2 CHD3 SIN3A	3.16e-04	346	54	6	int:SMARCA2
Interaction	U2AF2 interactions	DHX16 EPRS1 GANAB HLA-DMA ZC3H13 WWP2 CCAR1 CHD3	3.18e-04	651	54	8	int:U2AF2
Interaction	SND1 interactions	EPRS1 TRAP1 CSNK2A1 WWP1 WWP2 CHD3	3.21e-04	347	54	6	int:SND1
Interaction	SERBP1 interactions	DHX16 RAG1 EPRS1 TRAP1 GANAB CSNK2A1 ZC3H13 WWP2 PYGB CHD3 XPO1 STT3A	3.31e-04	1432	54	12	int:SERBP1
Interaction	ISG15 interactions	EPRS1 TRAP1 GANAB CBX5 CSNK2A1 ACTBL2 SIN3A	3.33e-04	494	54	7	int:ISG15
Interaction	KCTD9 interactions	EPRS1 TRAP1 SMUG1 ACTBL2 XPO1	3.36e-04	225	54	5	int:KCTD9
Interaction	GYS1 interactions	CSNK2A1 WWP2 PYGB XPO1	3.51e-04	125	54	4	int:GYS1
Interaction	SMARCC2 interactions	ITCH CSNK2A1 WWP2 SMARCD2 CHD3 SIN3A	3.52e-04	353	54	6	int:SMARCC2
Interaction	KIF23 interactions	DHX16 EPRS1 TRAP1 CSNK2A1 ZC3H13 CCAR1 CHD3 AK9 XPO1 CSNK2A3	3.60e-04	1031	54	10	int:KIF23
Interaction	CIT interactions	DHX16 RAG1 TRAP1 GANAB CBX5 CSNK2A1 ZC3H13 SMARCD2 CHD3 SIN3A XPO1 CSNK2A3	3.71e-04	1450	54	12	int:CIT
Interaction	CUL7 interactions	DHX16 EPRS1 TRAP1 GANAB CBX5 MRPS18B CSNK2A1 ACTBL2 MAPK6	3.74e-04	845	54	9	int:CUL7
Interaction	ILDR1 interactions	ITCH WWP1	3.82e-04	11	54	2	int:ILDR1
Interaction	CTR9 interactions	CSNK2A1 ACTBL2 CHD3 XPO1 CSNK2A3	3.95e-04	233	54	5	int:CTR9
Interaction	CUL4A interactions	WSB1 RAG1 ERCC8 EPRS1 SEC16B SUOX ZC3H13 AK9 XPO1	4.04e-04	854	54	9	int:CUL4A
Interaction	ARRDC2 interactions	ITCH WWP1 WWP2	4.09e-04	54	54	3	int:ARRDC2
Interaction	RPS9 interactions	EPRS1 MRPS18B CSNK2A1 WWP1 WWP2 CHD3 XPO1	4.28e-04	515	54	7	int:RPS9
Interaction	CCT4 interactions	ERCC8 GANAB ACTBL2 LOXL4 XPO1 MAPK6 MMACHC	4.28e-04	515	54	7	int:CCT4
Interaction	NDFIP2 interactions	ITCH WWP1 WWP2	4.56e-04	56	54	3	int:NDFIP2
Interaction	ANKRD36C interactions	CSNK2A1 CSNK2A3	4.57e-04	12	54	2	int:ANKRD36C
Interaction	PPP1R1B interactions	CSNK2A1 ACTBL2	4.57e-04	12	54	2	int:PPP1R1B
Interaction	MZB1 interactions	MAPK6 KLHL22	4.57e-04	12	54	2	int:MZB1
Interaction	POLR2B interactions	ITCH ZC3H13 WWP1 WWP2 XPO1 MAPK6	4.58e-04	371	54	6	int:POLR2B
Interaction	RPSA interactions	ERCC8 CBX5 CSNK2A1 WWP1 WWP2 CHD3 XPO1	4.64e-04	522	54	7	int:RPSA
Interaction	GATAD2B interactions	CSNK2A1 SMARCD2 CHD3 SIN3A CSNK2A3	4.96e-04	245	54	5	int:GATAD2B
Interaction	SUB1 interactions	RAB3GAP1 ITCH CBX5 CSNK2A1 XPO1	5.15e-04	247	54	5	int:SUB1
Interaction	LDLRAD4 interactions	ITCH WWP1 WWP2	5.32e-04	59	54	3	int:LDLRAD4
Interaction	IPMK interactions	CSNK2A1 CSNK2A3	5.39e-04	13	54	2	int:IPMK
Interaction	HAGHL interactions	CSNK2A1 CSNK2A3	5.39e-04	13	54	2	int:HAGHL
Interaction	TAB1 interactions	EPRS1 ITCH GANAB PTPRH XPO1	5.64e-04	252	54	5	int:TAB1
Interaction	E2F4 interactions	RAB3GAP1 GANAB CBX5 CSNK2A1 CCAR1 SIN3A XPO1	5.68e-04	540	54	7	int:E2F4
Interaction	DNAJA2 interactions	WDR19 ERCC8 PIGS WWP2 EIF2AK4 XPO1 MAPK6	5.80e-04	542	54	7	int:DNAJA2
Interaction	RBPJ interactions	CBX5 SMARCD2 CHD3 SIN3A XPO1	5.84e-04	254	54	5	int:RBPJ
Interaction	GPS2 interactions	SMUG1 CHD3 SIN3A XPO1	5.99e-04	144	54	4	int:GPS2
Interaction	PITPNM2 interactions	PITPNM2 XPO1	6.28e-04	14	54	2	int:PITPNM2
Interaction	STAM2 interactions	ITCH CBX5 XPO1 LCP2	6.47e-04	147	54	4	int:STAM2
Interaction	SIK1 interactions	ITCH SIN3A XPO1	6.75e-04	64	54	3	int:SIK1
Interaction	ZNF263 interactions	CBX5 MRPS18B CCAR1 SIN3A	6.81e-04	149	54	4	int:ZNF263
Interaction	RBX1 interactions	RAG1 ERCC8 TRAP1 GANAB CBX5 ACTBL2 KLHDC10	6.89e-04	558	54	7	int:RBX1
Interaction	UBA6 interactions	ITCH WWP2 AIPL1 PYGB	6.98e-04	150	54	4	int:UBA6
Interaction	ASH2L interactions	RAB3GAP1 CSNK2A1 WWP1 SIN3A XPO1	7.08e-04	265	54	5	int:ASH2L
Interaction	PRRG1 interactions	ITCH WWP1	7.24e-04	15	54	2	int:PRRG1
Interaction	UTP18 interactions	CSNK2A1 WWP2 LOXL4 XPO1	7.34e-04	152	54	4	int:UTP18
Interaction	TOM1L2 interactions	WWP2 SIN3A XPO1	7.39e-04	66	54	3	int:TOM1L2
GeneFamily	C2 and WW domain containing	WWP1 WWP2	2.05e-05	4	34	2	838
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#2_top-relative-expression-ranked_500	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	4.73e-05	162	52	5	gudmap_developingGonad_e16.5_epididymis_500_k2
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_200	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	5.46e-05	167	52	5	gudmap_developingGonad_e14.5_ epididymis_200
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#5_top-relative-expression-ranked_200	ITCH CBX5 CSNK2A1 ZC3H13	7.30e-05	91	52	4	gudmap_developingGonad_e14.5_ epididymis_200_k5
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#1_top-relative-expression-ranked_500	ITCH MTCP1 CBX5 ZC3H13	1.10e-04	101	52	4	gudmap_developingGonad_e14.5_ ovary_500_k1
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	2.21e-04	225	52	5	gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	2.45e-04	230	52	5	gudmap_developingGonad_e16.5_ovary_1000_k2
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#2_top-relative-expression-ranked_500	ITCH MTCP1 CBX5 ZC3H13	3.43e-04	136	52	4	gudmap_developingGonad_P2_epididymis_500_k2
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	3.53e-04	249	52	5	gudmap_developingGonad_P2_epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#3_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	4.23e-04	259	52	5	gudmap_developingGonad_e12.5_epididymis_k3_1000
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_500	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13 CRISPLD1	4.44e-04	404	52	6	gudmap_developingGonad_e18.5_epididymis_500
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_500	ITCH CBX5 CSNK2A1 ZC3H13	4.98e-04	150	52	4	gudmap_developingGonad_e12.5_epididymis_k5_500
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#5_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 ZC3H13	5.10e-04	151	52	4	gudmap_developingGonad_P2_ovary_1000_k5
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_k-means-cluster#2_top-relative-expression-ranked_500	MTCP1 CBX5 ZC3H13	5.44e-04	65	52	3	gudmap_developingGonad_P2_ovary_500_k2
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	5.55e-04	275	52	5	gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000	ITCH MTCP1 CBX5 CSNK2A1 ZC3H13	5.74e-04	277	52	5	gudmap_developingGonad_e12.5_ovary_k3_1000
Drug	MS-275; Down 200; 10uM; PC3; HT_HG-U133A	WDR19 EPRS1 RAB3GAP1 SUOX CSNK2A1 KLHDC10	5.02e-06	189	53	6	7074_DN
Disease	cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (implicated_via_orthology)	OXR1 NCOA7	3.41e-06	2	55	2	DOID:0070339 (implicated_via_orthology)
Disease	cortical surface area measurement	DHX16 PITPNM2 ERCC8 DCHS2 ITCH SUOX CBX5 ZC3H13 CCAR1 XPO1 MAPK6 PLCE1	5.44e-06	1345	55	12	EFO_0010736
Disease	body fat distribution	PITPNM2 SEC16B WWP2 AIPL1 PLCE1	3.77e-05	202	55	5	EFO_0004341
Disease	ascending aortic diameter	RERG WWP2 CRISPLD1 PLCE1	1.37e-04	140	55	4	EFO_0021787
Disease	gastric adenocarcinoma (is_implicated_in)	XPO1 PLCE1	1.86e-04	11	55	2	DOID:3717 (is_implicated_in)
Disease	inherited metabolic disorder (is_implicated_in)	SUOX BCHE	3.53e-04	15	55	2	DOID:655 (is_implicated_in)
Disease	functional brain measurement	PYGB LOXL4 PLCE1	4.89e-04	82	55	3	EFO_0007849
Disease	sudden cardiac arrest	RAB3GAP1 SIN3A PLCE1	5.07e-04	83	55	3	EFO_0004278
Disease	descending aortic diameter	WWP2 CRISPLD1 PLCE1	6.01e-04	88	55	3	EFO_0021788
Disease	Seizures	OXR1 CSNK2A1 HACE1 BCHE	7.36e-04	218	55	4	C0036572
Disease	aortic measurement	RERG WWP2 CRISPLD1 PLCE1	1.24e-03	251	55	4	EFO_0020865

Protein segments in the cluster

Peptide	Gene	Start	Entry
YTDWVDDQRPENYRE	BCHE	401	P06276
PNYYSVDDRWEEQRA	DISP3	406	Q9P2K9
AYYVRARAHAEVWNE	AIPL1	266	Q9NZN9
AFYEERLTWHAYPED	CBX5	166	P45973
ENIVRYYNAWIERHE	EIF2AK4	646	Q9P2K8
IWYHTFYNELRVAPD	ACTBL2	86	Q562R1
QWYRFAEIRYHRPEE	CCAR1	541	Q8IX12
RLYTAWAYQHELEET	DHX16	736	O60231
NLERYEVWRSNPYHE	RAG1	756	P15918
EDFVRWYSPRDYIEE	RAB3GAP1	696	Q15042
TDYARWREAQAPYRV	LARGE2	596	Q8N3Y3
SEVPVDSHYYRKVWD	LOXL4	211	Q96JB6
DNEDYPLFRELWRYH	KLHDC10	121	Q6PID8
NLVWRESEVNHYYEP	MAPK6	456	Q16659
EYTSGYEREDPVIQW	HACE1	801	Q8IYU2
ALRVVEESWNAYPYT	PITPNM2	81	Q9BZ72
RDWTYRDAVTPQERY	MMACHC	201	Q9Y4U1
DVHRYSVETVQWYPH	ERCC8	96	Q13216
HDWTRENTYVEYSII	DCHS2	2576	Q6V1P9
YWFAVPQERTDHLYA	OXR1	591	Q8N573
RVYYVDHVEKRTTWD	ITCH	341	Q96J02
VYTDVNTHRPREYWD	CSNK2A3	11	Q8NEV1
NTHRPREYWDYESHV	CSNK2A3	16	Q8NEV1
VERYDPATNSWAYVA	KLHL22	416	Q53GT1
HEYVSEIGWRIPQYN	C4orf45	71	Q96LM5
PEYEEHKQSYWRHRE	CHD3	671	Q12873
RYRPPTFHVQSWYDE	CRISPLD1	126	Q9H336
HEIDRYTAIAYWVPR	HLA-DMA	206	P28067
VYTDVNTHRPREYWD	CSNK2A1	11	P68400
NTHRPREYWDYESHV	CSNK2A1	16	P68400
EDYKYPRETETIWSH	SCP2D1-AS1	11	Q9BR46
HDVYWDIEGAVRRYV	PIGS	241	Q96S52
YSRDQWDPEVIENHR	AK9	171	Q5TCS8
TTEYHDRDEQFYWII	EPRS1	396	P07814
YWFAVPRERVDHLYT	NCOA7	691	Q8NI08
HQEGIYRDEYQRTWV	MTCP1	16	P56278
SEAQWYPIYNAVRRE	PLCE1	396	Q9P212
YHQSRWNYRDEADVL	GANAB	396	Q14697
REAYYWLRHNTPEDA	STT3A	506	P46977
DPVEAERWSDYVERY	SIN3A	1091	Q96ST3
YIEDWQFVNDYRHPV	WDR19	501	Q8NEZ3
FIWEYDPTLESTYRH	RERG	31	Q96A58
EERRAAFYHQPWAQE	SMARCD2	491	Q92925
SEEYQERYGSRPVWA	MRPS18B	61	Q9Y676
EYWNHLAAELYRESP	XPO1	371	O14980
TTWQRPTAEYVRNYE	WWP2	356	O00308
GRWIRTQQHYYERDP	PYGB	66	P11216
QRSPYIWHEDYREQK	SEC16B	141	Q96JE7
NPVEYAWEPHRNYVT	SMUG1	56	Q53HV7
EYRASHSTPIEWYLD	TSPY8	226	P0CW00
VREWQHEEFYRYVAQ	TRAP1	306	Q12931
VQPEESYSHWQRRDY	SUOX	386	P51687
YDTRVYIWDPHNGDI	WSB1	276	Q9Y6I7
YYVDHNTRTTTWERP	WWP1	366	Q9H0M0
YHLTVWAERNEVRGY	PTPRH	541	Q9HD43
NYHDSWETRSSYPER	ZC3H13	591	Q5T200
EEWYHVDPAQRSLYR	ZFP90	26	Q8TF47
DDDDEYPWRQNAHRY	TMEM272	91	A0A1B0GTI8
EWYVSYITRPEAEAA	LCP2	421	Q13094