Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization involved in mitosis	SETD2 DCTN2 STIL GOLGA8A CEP97 GOLGA2 SPDL1	5.31e-06	187	75	7	GO:1902850
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization	CYLD SETD2 DCTN2 CEP295 MTCL1 STIL GOLGA8A CAMSAP2 DICER1 CEP97 GOLGA2 SPDL1	1.04e-05	720	75	12	GO:0000226
GeneOntologyBiologicalProcess	cellular component disassembly	SPTAN1 ADGRB3 TCF25 TRIOBP STING1 SMCR8 GOLGA8A CAMSAP2 CTSK DICER1 GOLGA2	1.35e-05	617	75	11	GO:0022411
GeneOntologyBiologicalProcess	microtubule-based process	CYLD SETD2 DNAH10 DCTN2 CEP295 MTCL1 STIL GOLGA8A CAMSAP2 DICER1 ATP2B4 CEP97 GOLGA2 SPDL1	2.39e-05	1058	75	14	GO:0007017
GeneOntologyBiologicalProcess	chromosome segregation	DCTN2 MTCL1 STIL PUM1 GOLGA8A DICER1 CEP97 GOLGA2 SPDL1	4.68e-05	465	75	9	GO:0007059
GeneOntologyBiologicalProcess	cell cycle process	BLM SETD2 NFATC1 SND1 DCTN2 TIPIN CEP295 MTCL1 STIL PUM1 GOLGA8A DICER1 ATP2B4 CEP97 GOLGA2 SPDL1	4.94e-05	1441	75	16	GO:0022402
GeneOntologyBiologicalProcess	regulation of cell cycle	BLM CYLD EPC2 HHEX SETD2 SND1 TIPIN CEP295 STIL PUM1 DICER1 ATP2B4 CEP97 SPDL1	1.52e-04	1256	75	14	GO:0051726
GeneOntologyBiologicalProcess	spindle organization	DCTN2 STIL GOLGA8A DICER1 CEP97 GOLGA2	1.65e-04	224	75	6	GO:0007051
GeneOntologyCellularComponent	centrosome	CYLD TBC1D31 CEP85L DCTN2 TRIOBP CEP295 STIL ALDOB CAMSAP2 CEP97 SPDL1	9.00e-05	770	75	11	GO:0005813
GeneOntologyCellularComponent	microtubule	CYLD DNAH10 DCTN2 CEP295 MTCL1 GOLGA8A CAMSAP2 ZNF804A GOLGA2	1.20e-04	533	75	9	GO:0005874
GeneOntologyCellularComponent	supramolecular fiber	CYLD DNAH10 DCTN2 SPTAN1 CEP295 MTCL1 ACTN3 GOLGA8A CAMSAP2 ZNF804A ATP2B4 GOLGA2 RYR1	2.64e-04	1179	75	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	CYLD DNAH10 DCTN2 SPTAN1 CEP295 MTCL1 ACTN3 GOLGA8A CAMSAP2 ZNF804A ATP2B4 GOLGA2 RYR1	2.82e-04	1187	75	13	GO:0099081
GeneOntologyCellularComponent	microtubule organizing center	CYLD TBC1D31 CEP85L DCTN2 TRIOBP CEP295 STIL ALDOB CAMSAP2 CEP97 SPDL1	4.16e-04	919	75	11	GO:0005815
MousePheno	lethality throughout fetal growth and development, complete penetrance	BLM NCOA6 HHEX NFATC1 SPTAN1 DICER1 RYR1 ZFPM2 TULP3	2.87e-06	263	64	9	MP:0011099
MousePheno	abnormal fluid regulation	NCOA6 HHEX SETD2 ADAM19 NFATC1 RBM45 SPTAN1 STING1 F2 CEP97 ADCY9 RYR1 ZFPM2 TULP3	1.70e-05	826	64	14	MP:0001784
MousePheno	lethality throughout fetal growth and development	BLM NCOA6 HHEX NFATC1 SPTAN1 F2 DICER1 RYR1 ZFPM2 TULP3	2.58e-05	435	64	10	MP:0006208
MousePheno	thin myocardium compact layer	NCOA6 HHEX SPTAN1 ZFPM2	5.64e-05	46	64	4	MP:0004057
MousePheno	edema	HHEX SETD2 ADAM19 NFATC1 RBM45 SPTAN1 CEP97 ADCY9 RYR1 ZFPM2 TULP3	5.82e-05	581	64	11	MP:0001785
MousePheno	heart right ventricle outflow tract stenosis	HHEX ADAM19 ZFPM2	8.42e-05	19	64	3	MP:0010449
MousePheno	abnormal heart right ventricle outflow tract morphology	HHEX ADAM19 NFATC1 ZFPM2	9.89e-05	53	64	4	MP:0010428
MousePheno	abnormal right lung accessory lobe morphology	ADCY9 ZFPM2	2.05e-04	5	64	2	MP:0009571
MousePheno	abnormal semilunar valve development	ADAM19 NFATC1	2.05e-04	5	64	2	MP:0031553
MousePheno	abnormal axon initial segment morphology	SPTAN1 MTCL1	2.05e-04	5	64	2	MP:0010733
MousePheno	abnormal tricuspid valve morphology	ADAM19 NFATC1 ZFPM2	2.21e-04	26	64	3	MP:0002624
MousePheno	abnormal myocardium compact layer morphology	NCOA6 HHEX SPTAN1 ZFPM2	2.47e-04	67	64	4	MP:0004056
MousePheno	abnormal atrioventricular valve morphology	HHEX ADAM19 NFATC1 ZFPM2	2.76e-04	69	64	4	MP:0002745
MousePheno	abnormal skin appearance	BLM NCOA6 NFATC1 STING1 F2 CEP97 RYR1 ZFPM2 TULP3	2.84e-04	473	64	9	MP:0009931
MousePheno	abnormal heart atrium and ventricle connection	HHEX ADAM19 NFATC1 ZFPM2	3.81e-04	75	64	4	MP:0010435
MousePheno	abnormal atrioventricular cushion morphology	HHEX ADAM19 NFATC1 ZFPM2	4.00e-04	76	64	4	MP:0000297
MousePheno	abnormal fetal atrioventricular canal morphology	HHEX ADAM19 NFATC1 ZFPM2	5.10e-04	81	64	4	MP:0006107
MousePheno	abnormal heart valve development	ADAM19 NFATC1	5.68e-04	8	64	2	MP:0031549
MousePheno	abnormal hepatic diverticulum morphology	NCOA6 HHEX	5.68e-04	8	64	2	MP:0012234
MousePheno	abnormal liver bud morphology	NCOA6 HHEX	5.68e-04	8	64	2	MP:0012235
Domain	EF-hand_Ca_insen	SPTAN1 ACTN3	2.30e-04	6	74	2	IPR014837
Domain	EFhand_Ca_insen	SPTAN1 ACTN3	2.30e-04	6	74	2	PF08726
Domain	GOLGA2L5	GOLGA8A GOLGA2	2.27e-03	18	74	2	PF15070
Domain	Golgin_A	GOLGA8A GOLGA2	2.27e-03	18	74	2	IPR024858
Domain	-	EHBP1 ACTN3 CAMSAP2	2.81e-03	71	74	3	1.10.418.10
Domain	CH	EHBP1 ACTN3 CAMSAP2	3.04e-03	73	74	3	PS50021
Domain	CH-domain	EHBP1 ACTN3 CAMSAP2	3.29e-03	75	74	3	IPR001715
Domain	Spectrin	SPTAN1 ACTN3	3.71e-03	23	74	2	PF00435
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CYLD NCOA6 ADGRB3 TRIOBP DICER1 ADCY9 UNC80	5.90e-07	225	75	7	12168954
Pubmed	The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.	DCTN2 SPTAN1 GOLGA8A GOLGA2	6.85e-07	32	75	4	23704327
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	TBC1D31 CEP85L DCTN2 CEP295 STIL CEP97	7.83e-07	146	75	6	21399614
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCOA6 UBXN4 ZNF507 ADGRB3 ZBTB5 TRIOBP CACHD1 DICER1 ADCY9	2.10e-06	529	75	9	14621295
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	BLM MTMR4 UBXN4 TBC1D31 SPTAN1 TRIOBP CACHD1 PUM1 PPP6R2 ATP2B4 ADCY9 TULP3	2.42e-06	1049	75	12	27880917
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CYLD CEP295 STIL PUM1 CEP97	2.75e-06	101	75	5	24613305
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	BLM CYLD UBXN4 TBC1D31 SND1 DCTN2 SPTAN1 BAG4 TRIOBP PPP6R2 SMCR8 DICER1 ATP2B4 ADCY9	3.12e-06	1487	75	14	33957083
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SETD2 MTMR4 UBXN4 TBC1D31 CEP295 PRR14L PUM1 DICER1 ADCY9 SPDL1	3.93e-06	733	75	10	34672954
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	CEP85L GOLGA8A GOLGA2 ZFPM2 SPDL1	4.37e-06	111	75	5	22558309
Pubmed	The Ca2+ export pump PMCA clears near-membrane Ca2+ to facilitate store-operated Ca2+ entry and NFAT activation.	NFATC1 ATP2B4	4.59e-06	2	75	2	31594854
Pubmed	Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption.	CTSK DICER1	4.59e-06	2	75	2	20039311
Pubmed	Transcription Factor Hematopoietically Expressed Homeobox Protein (Hhex) Negatively Regulates Osteoclast Differentiation by Controlling Cyclin-Dependent Kinase Inhibitors.	HHEX CTSK	4.59e-06	2	75	2	35434453
Pubmed	The calcium pump PMCA4 prevents epithelial-mesenchymal transition by inhibiting NFATc1-ZEB1 pathway in gastric cancer.	NFATC1 ATP2B4	1.37e-05	3	75	2	32860837
Pubmed	Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.	PAPPA2 F2	1.37e-05	3	75	2	9883900
Pubmed	NF-κB, Sp1 and NF-Y as transcriptional regulators of human SND1 gene.	SP1 SND1	1.37e-05	3	75	2	23160072
Pubmed	PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing.	PUM1 DICER1	1.37e-05	3	75	2	35736218
Pubmed	The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway.	CYLD STING1	1.37e-05	3	75	2	30388174
Pubmed	PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.	MTMR4 STING1	1.37e-05	3	75	2	30944173
Pubmed	Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.	NFATC1 CTSK	1.37e-05	3	75	2	20133620
Pubmed	25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p.	SP1 NFATC1	1.37e-05	3	75	2	28257846
Pubmed	Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand.	NFATC1 CTSK	1.37e-05	3	75	2	19563866
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CYLD TBC1D31 CEP85L DCTN2 ZNF507 CEP295 STIL PPP6R2 CAMSAP2 CEP97	1.47e-05	853	75	10	28718761
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CYLD EHBP1 NCOA6 MTMR4 CEP85L SPTAN1 MTCL1 STIL PUM1 CAMSAP2	1.59e-05	861	75	10	36931259
Pubmed	Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.	DNAH10 DCTN2	2.75e-05	4	75	2	26517670
Pubmed	Cellular actions of the insulin-like growth factor binding proteins.	PAPPA2 F2	2.75e-05	4	75	2	12466191
Pubmed	HER-2/neu represses the metastasis suppressor RECK via ERK and Sp transcription factors to promote cell invasion.	SP1 RECK	2.75e-05	4	75	2	16377629
Pubmed	Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.	NCOA6 NFATC1	2.75e-05	4	75	2	28341745
Pubmed	Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity.	SP1 RECK	2.75e-05	4	75	2	25885317
Pubmed	Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.	SND1 DICER1	2.75e-05	4	75	2	28546213
Pubmed	A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.	TRIOBP ILDR1	2.75e-05	4	75	2	27764096
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	SETD2 SND1 RBM45 DCTN2 TCF25 TRIOBP GOLGA2 ZFPM2	2.81e-05	560	75	8	21653829
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CYLD TCF25 PACS2 MTCL1 PUM1 CAMSAP2 SENP7	2.86e-05	407	75	7	12693553
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	MTMR4 TCF25 PPP6R2 DICER1 CEP97	3.16e-05	167	75	5	25659891
Pubmed	Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development.	TIPIN GOLGA8A GOLGA2	3.38e-05	29	75	3	20568244
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CYLD SPTAN1 ADGRB3 TRIOBP MTCL1 PPP6R2 GOLGA8A CAMSAP2 ATP2B4 GOLGA2	4.11e-05	963	75	10	28671696
Pubmed	Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells.	SP1 NFATC1	4.57e-05	5	75	2	14979875
Pubmed	Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.	SP1 F2	4.57e-05	5	75	2	12911579
Pubmed	CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).	NFATC1 CTSK	4.57e-05	5	75	2	20721934
Pubmed	Mapping the Genetic Landscape of Human Cells.	TBC1D31 DCTN2 TIPIN TCF25 CEP295 DICER1 SPDL1	5.47e-05	451	75	7	30033366
Pubmed	Role of the captured retroviral envelope syncytin-B gene in the fusion of osteoclast and giant cell precursors and in bone resorption, analyzed ex vivo and in vivo in syncytin-B knockout mice.	NFATC1 CTSK	6.84e-05	6	75	2	31360740
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CYLD MTCL1 CAMSAP2 DICER1 CEP97	9.16e-05	209	75	5	36779422
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD DCHS2 ADAM19 CNST CEP85L SPTAN1 ADGRB3 ZBTB5 TRIOBP CACHD1 RECK	9.40e-05	1285	75	11	35914814
Pubmed	Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.	NFATC1 CTSK	9.57e-05	7	75	2	15304486
Pubmed	VEGF and RANKL regulation of NFATc1 in heart valve development.	NFATC1 CTSK	9.57e-05	7	75	2	19661463
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	TCF25 PPP6R2 DICER1 TULP3 SENP7	1.24e-04	223	75	5	33187986
Pubmed	NFATC1 promotes epicardium-derived cell invasion into myocardium.	NFATC1 CTSK	1.27e-04	8	75	2	21447555
Pubmed	NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.	NFATC1 CTSK	1.27e-04	8	75	2	16680826
Pubmed	A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.	NFATC1 ZFPM2	1.27e-04	8	75	2	10888889
Pubmed	A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene.	SP1 ZBTB5	1.27e-04	8	75	2	19491398
Pubmed	LMO7 deficiency reveals the significance of the cuticular plate for hearing function.	SPTAN1 TRIOBP	1.27e-04	8	75	2	30850599
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PAPPA2 MAB21L3 ZNF507 ZBTB5 PUM1 SENP7	1.36e-04	363	75	6	14691545
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CYLD EPC2 SETD2 BAG4 TCF25 CEP295 DICER1 ADCY9 UNC80 SENP7	1.39e-04	1116	75	10	31753913
Pubmed	Hdac6 regulates Tip60-p400 function in stem cells.	EPC2 SPTAN1 RAB5C	1.55e-04	48	75	3	24302573
Pubmed	Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.	NFATC1 ATP2B4	1.64e-04	9	75	2	12660151
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	CYLD EHBP1 UBXN4 CNST SPTAN1 ADGRB3 TCF25 TRIOBP PPP6R2 CAMSAP2	1.64e-04	1139	75	10	36417873
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	NCOA6 DICER1	2.04e-04	10	75	2	20721975
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	CYLD TBC1D31 TRIOBP CAMSAP2 CEP97	2.15e-04	251	75	5	29778605
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	EHBP1 UBXN4 SPTAN1 PRR14L GOLGA2 ADCY9 SPDL1	2.27e-04	568	75	7	37774976
Pubmed	Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression.	SP1 NFATC1	2.49e-04	11	75	2	20375015
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BLM CYLD SETD2 NFATC1 ZNF507 PPP6R2 GOLGA2	2.80e-04	588	75	7	38580884
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	SETD2 ZBTB25 PUM1 PPP6R2 CAMSAP2 ZNF804A ZFPM2	3.42e-04	608	75	7	16713569
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB6 ZBTB25 ZBTB5	3.49e-04	63	75	3	34351428
Pubmed	Yeast two-hybrid screens implicate DISC1 in brain development and function.	SPTAN1 GOLGA2	3.52e-04	13	75	2	14623284
Pubmed	Globozoospermia and lack of acrosome formation in GM130-deficient mice.	GOLGA8A GOLGA2	3.52e-04	13	75	2	28055014
Pubmed	GM130 regulates pulmonary surfactant protein secretion in alveolar type II cells.	GOLGA8A GOLGA2	3.52e-04	13	75	2	33740186
Pubmed	Loss of GM130 does not impair oocyte meiosis and embryo development in mice.	GOLGA8A GOLGA2	3.52e-04	13	75	2	32873390
Pubmed	GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte.	GOLGA8A GOLGA2	3.52e-04	13	75	2	21552007
Pubmed	GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.	GOLGA8A GOLGA2	3.52e-04	13	75	2	29128360
Pubmed	Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice.	GOLGA8A GOLGA2	3.52e-04	13	75	2	28028212
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CYLD EHBP1 SETD2 TCF25 PUM1 PPP6R2 CAMSAP2 CEP97 GOLGA2	3.90e-04	1038	75	9	26673895
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CYLD SPTAN1 CEP295 MTCL1 PUM1 PPP6R2	4.10e-04	446	75	6	24255178
Pubmed	GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.	GOLGA8A GOLGA2	4.11e-04	14	75	2	30630895
Pubmed	Th2 and eosinophil responses suppress inflammatory arthritis.	NFATC1 CTSK	4.11e-04	14	75	2	27273006
Pubmed	Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation.	GOLGA8A GOLGA2	4.11e-04	14	75	2	37831422
Pubmed	CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.	CEP295 CEP97	4.11e-04	14	75	2	32060285
Pubmed	Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.	GOLGA8A GOLGA2	4.11e-04	14	75	2	27226319
Pubmed	Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice.	GOLGA8A GOLGA2	4.11e-04	14	75	2	33543287
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	BLM EHBP1 UBXN4 SPTAN1 SMCR8 DICER1 MCOLN3 RYR1 RAB5C SPDL1	4.50e-04	1293	75	10	15342556
Pubmed	GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.	GOLGA8A GOLGA2	4.73e-04	15	75	2	26165940
Pubmed	Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.	GOLGA8A GOLGA2	4.73e-04	15	75	2	17204322
Pubmed	Demonstration of the expression and the enzymatic activity of N-acetylglucosaminyltransferase IX in the mouse brain.	GOLGA8A GOLGA2	4.73e-04	15	75	2	16413118
Pubmed	Golgi disruption and early embryonic lethality in mice lacking USO1.	GOLGA8A GOLGA2	4.73e-04	15	75	2	23185636
Pubmed	The a3 isoform of V-ATPase regulates insulin secretion from pancreatic beta-cells.	GOLGA8A GOLGA2	4.73e-04	15	75	2	17046993
Pubmed	Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body.	GOLGA8A GOLGA2	4.73e-04	15	75	2	17189423
Pubmed	Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.	NFATC1 ZFPM2	4.73e-04	15	75	2	23797856
Pubmed	RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis.	GOLGA8A GOLGA2	4.73e-04	15	75	2	26083584
Pubmed	WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.	GOLGA8A GOLGA2	4.73e-04	15	75	2	37635409
Pubmed	Golga5 is dispensable for mouse embryonic development and postnatal survival.	GOLGA8A GOLGA2	4.73e-04	15	75	2	28509431
Pubmed	LIM kinase 2 is widely expressed in all tissues.	GOLGA8A GOLGA2	5.40e-04	16	75	2	16399995
Pubmed	hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.	BLM TIPIN	5.40e-04	16	75	2	24126761
Pubmed	Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.	GOLGA8A GOLGA2	5.40e-04	16	75	2	11784862
Pubmed	p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.	GOLGA8A GOLGA2	5.40e-04	16	75	2	21640725
Pubmed	Molecular characterization of mitocalcin, a novel mitochondrial Ca2+-binding protein with EF-hand and coiled-coil domains.	GOLGA8A GOLGA2	5.40e-04	16	75	2	16336229
Pubmed	SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.	GOLGA8A GOLGA2	5.40e-04	16	75	2	18166528
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BLM NCOA6 CEP97 GOLGA2 RAB5C SPDL1	5.53e-04	472	75	6	38943005
Pubmed	Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis.	GOLGA8A GOLGA2	6.11e-04	17	75	2	14718562
Pubmed	Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.	GOLGA8A GOLGA2	6.11e-04	17	75	2	28717168
Pubmed	FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.	HHEX ZFPM2	6.11e-04	17	75	2	17274974
Pubmed	MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway.	NFATC1 DICER1	6.11e-04	17	75	2	23974039
Pubmed	The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.	GOLGA8A GOLGA2	6.11e-04	17	75	2	27655914
Interaction	EGLN3 interactions	BLM CYLD NFATC1 DCTN2 ZNF507 TCF25 ZBTB5 CEP295 PRR14L CACHD1 MTCL1 STIL PUM1 PPP6R2 CAMSAP2 DICER1 CEP97 ZFPM2	4.67e-07	1296	72	18	int:EGLN3
Interaction	GJA1 interactions	EHBP1 UBXN4 SND1 CNST SPTAN1 CACHD1 SMCR8 ATP2B4 GOLGA2 ADCY9 RAB5C TULP3	9.68e-07	583	72	12	int:GJA1
Interaction	PCM1 interactions	CYLD TBC1D31 CEP85L TRIOBP CEP295 STIL CAMSAP2 CEP97 GOLGA2 SPDL1	3.15e-06	434	72	10	int:PCM1
Interaction	TMT1A interactions	EHBP1 UBXN4 SND1 CACHD1 STING1 SMCR8 GOLGA2 ADCY9 SPDL1	5.18e-06	359	72	9	int:TMT1A
Interaction	PLK1 interactions	CYLD MTMR4 TCF25 TRIOBP STING1 PPP6R2 DICER1 CEP97 GOLGA2 SENP7	1.30e-05	510	72	10	int:PLK1
Interaction	DYRK1A interactions	CYLD DCHS2 ADAM19 DCTN2 SPTAN1 TRIOBP CACHD1 CAMSAP2 GOLGA2 RECK	2.56e-05	552	72	10	int:DYRK1A
Interaction	ZFPL1 interactions	EHBP1 MTMR4 SPTAN1 CACHD1 STING1 SMCR8 GOLGA2 RAB5C TULP3	3.01e-05	448	72	9	int:ZFPL1
Interaction	NIN interactions	CYLD TBC1D31 CEP85L DCTN2 CEP295 STIL CAMSAP2 CEP97	4.16e-05	359	72	8	int:NIN
Interaction	STIM1 interactions	UBXN4 SND1 BAG4 STING1 SMCR8 ATP2B4 ADCY9 RAB5C	7.17e-05	388	72	8	int:STIM1
Interaction	GATA2 interactions	NCOA6 HHEX NFATC1 SPTAN1 GOLGA2 ZFPM2	7.81e-05	199	72	6	int:GATA2
Interaction	MAPRE1 interactions	CYLD TBC1D31 SND1 DCTN2 SPTAN1 STING1 CAMSAP2 CEP97 SPDL1	8.70e-05	514	72	9	int:MAPRE1
GeneFamily	Cadherin related	DCHS2 CDHR1	7.69e-04	17	44	2	24
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	BLM EHBP1 SETD2 TBC1D31 MTCL1 STIL PUM1 CAMSAP2 ZNF804A DICER1 ATP2B4 ADCY9	4.65e-06	856	74	12	M4500
Coexpression	GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_RAG2_KO_NK_CELL_UP	EHBP1 TBC1D31 MTCL1 CAMSAP2 CTSK ATP2B4	1.91e-05	195	74	6	M8872
Coexpression	GSE25123_WT_VS_PPARG_KO_MACROPHAGE_IL4_AND_ROSIGLITAZONE_STIM_DN	ATP8B4 TMEM87B CDHR1 ZBTB5 SMCR8 CEP97	2.02e-05	197	74	6	M7921
Coexpression	GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY8_EFFECTOR_CD8_TCELL_DN	SP1 MTMR4 ADAM19 BAG4 CEP97 RYR1	2.20e-05	200	74	6	M9479
Coexpression	BRUINS_UVC_RESPONSE_EARLY_LATE	NCOA6 ZBTB25 STING1 STIL PUM1 UNC80 TULP3	3.12e-05	316	74	7	M2248
Coexpression	BRUINS_UVC_RESPONSE_EARLY_LATE	NCOA6 ZBTB25 STING1 STIL PUM1 UNC80 TULP3	3.38e-05	320	74	7	MM1063
Coexpression	YAGI_AML_WITH_T_9_11_TRANSLOCATION	CYLD ZBTB25 F2 ADCY9 RYR1	3.53e-05	131	74	5	M16922
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	BLM EHBP1 SETD2 MTCL1 STIL PUM1 CAMSAP2 ZNF804A	5.07e-05	466	74	8	M13522
Coexpression	GSE6269_E_COLI_VS_STAPH_AUREUS_INF_PBMC_UP	CYLD SND1 MTCL1 PUM1 CAMSAP2	8.10e-05	156	74	5	M5659
Coexpression	RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN	EPC2 CDHR1 PUM1 SMCR8 GOLGA8A GOLGA2	1.69e-04	289	74	6	MM1238
Coexpression	GSE41867_DAY8_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_UP	BLM EHBP1 ADGRB3 PACS2 CEP295	2.09e-04	191	74	5	M9517
Coexpression	GSE21927_SPLENIC_VS_TUMOR_MONOCYTES_FROM_C26GM_TUMOROUS_MICE_BALBC_DN	CYLD SETD2 SPTAN1 TRIOBP GOLGA8A	2.47e-04	198	74	5	M7605
Coexpression	GSE4142_GC_BCELL_VS_MEMORY_BCELL_UP	EPC2 HHEX ADAM19 CNST TCF25	2.59e-04	200	74	5	M6397
Coexpression	GSE19941_IL10_KO_VS_IL10_KO_AND_NFKBP50_KO_UNSTIM_MACROPHAGE_DN	PACS2 F2 ZNF804A RECK TULP3	2.59e-04	200	74	5	M8110
Coexpression	GSE411_UNSTIM_VS_100MIN_IL6_STIM_MACROPHAGE_DN	ADAM19 TMEM87B ZNF507 DICER1 CEP97	2.59e-04	200	74	5	M5986
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_UP	CYLD HHEX SPTAN1 PPP6R2 CTSK	2.59e-04	200	74	5	M8320
Coexpression	GSE14769_UNSTIM_VS_20MIN_LPS_BMDM_DN	CYLD HHEX UBXN4 BAG4 STIL	2.59e-04	200	74	5	M3491
Coexpression	GSE360_T_GONDII_VS_B_MALAYI_HIGH_DOSE_DC_DN	HHEX CDHR1 ZNF507 PPP6R2 RAB5C	2.59e-04	200	74	5	M5216
Coexpression	GSE17186_CD21LOW_VS_CD21HIGH_TRANSITIONAL_BCELL_CORD_BLOOD_DN	HHEX NFATC1 ZBTB25 SPTAN1 CEP97	2.59e-04	200	74	5	M7193
Coexpression	GSE15735_CTRL_VS_HDAC_INHIBITOR_TREATED_CD4_TCELL_2H_DN	ATP8B4 ADAM19 CRTAM ILDR1 RECK	2.59e-04	200	74	5	M7161
Coexpression	GSE3982_MAST_CELL_VS_TH2_DN	BLM TBC1D31 TIPIN PPP6R2 GOLGA8A	2.59e-04	200	74	5	M5456
Coexpression	GSE7460_FOXP3_MUT_VS_WT_ACT_WITH_TGFB_TCONV_DN	CEP97 RECK ADCY9 UNC80 SENP7	2.59e-04	200	74	5	M5705
Coexpression	GSE7852_LN_VS_FAT_TREG_UP	MTMR4 BAG4 PRR14L STING1 CEP97	2.59e-04	200	74	5	M5739
Coexpression	GSE2770_IL12_ACT_VS_ACT_CD4_TCELL_48H_UP	EHBP1 MAB21L3 SND1 GOLGA2 RECK	2.59e-04	200	74	5	M6032
Coexpression	GSE20366_TREG_VS_NAIVE_CD4_TCELL_DEC205_CONVERSION_DN	NCOA6 ATP8B4 TBC1D31 NFATC1 CEP97	2.59e-04	200	74	5	M4334
Coexpression	TSUTSUMI_FBXW8_TARGETS	ACTN3 RYR1	2.79e-04	9	74	2	MM888
Coexpression	TSUTSUMI_FBXW8_TARGETS	ACTN3 RYR1	2.79e-04	9	74	2	M2187
Coexpression	LUI_THYROID_CANCER_PAX8_PPARG_UP	GOLGA8A ADCY9 TULP3	3.01e-04	46	74	3	M4381
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA2 CFAP20DC DNAH10 MTCL1 CTSK CEP97 HSF5	1.75e-08	173	75	7	506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CYLD CEP85L ZNF507 GOLGA8A ATP2B4	9.28e-06	167	75	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	BLM TBC1D31 TIPIN STIL SPDL1	1.44e-05	183	75	5	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	CD8+_Memory_T_cell-CV-6\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	CYLD SPTAN1 CRTAM TCF25 ATP2B4	1.91e-05	194	75	5	35a347c3824757b9de8b7f49db46e73e7fb63a4f
ToppCell	CV-Severe-6\|Severe / Virus stimulation, Condition and Cluster	DCTN2 SPTAN1 CRTAM TCF25 ATP2B4	1.91e-05	194	75	5	d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Interneuron\|1m / Sample Type, Dataset, Time_group, and Cell type.	EHBP1 DCHS2 MTMR4 SPTAN1 ZNF804A	2.21e-05	200	75	5	fc839e9c33ea1d4ee0f42f21fd32a54e7cbe1f5a
Disease	obesity (implicated_via_orthology)	DCHS2 DNAH10 PUM1 F2 TULP3	2.10e-04	215	74	5	DOID:9970 (implicated_via_orthology)
Disease	telomere length	ATP8B4 ILDR1 CEP295 UNC80 SENP7	1.15e-03	313	74	5	EFO_0004505
Disease	TEMPS-A questionnaire	ADGRB3 CEP295	1.79e-03	25	74	2	EFO_0004783
Disease	Thyroid preparation use measurement	NFATC1 ILDR1 CAMSAP2 RAB5C	2.19e-03	217	74	4	EFO_0009933

Protein segments in the cluster

Peptide	Gene	Start	Entry
PNNQDQSSSLPEECV	BAG4	356	O95429
NLSPQNLVDCVSEND	CTSK	161	P43235
PRLDQANHSCENSEL	EPC2	411	Q52LR7
QCFQPRLLNLQDSDS	EPC2	526	Q52LR7
SDNEEAPLREQCQNP	SLC4A9	201	Q96Q91
ENCNNNSPESSLLPR	CDHR1	776	Q96JP9
RLRNCQDPINADSSS	ADGRB3	1161	O60242
QCQSSEARPLESNAV	ADAM19	576	Q9H013
DQCPSSLAIQENANA	ALDOB	156	P05062
ECTGNLTNAENRNPS	CACHD1	981	Q5VU97
DQDVSDQNSVDCPQL	ATP8B4	926	Q8TF62
TAVRCDQDAQNPLSA	DCTN2	236	Q13561
ENQPQPSDECTLLSN	DICER1	1226	Q9UPY3
DCNQVQLPQSDSSLQ	ATP2B4	1221	P23634
PSQAAQAIENCDRSF	RBM45	171	Q8IUH3
DLQENNPASRSQCCS	RAB5C	201	P51148
NRPTELFRSCNAQSD	RECK	361	O95980
TFNQDDSADLRCQLQ	MTCL1	496	Q9Y4B5
ENSLNSNPVCDLDST	KIAA1107	586	Q9UPP5
EENRCNFNQQTSPSE	MCOLN3	16	Q8TDD5
LDSSCDQRQDLPSEQ	HHEX	211	Q03014
LDVANLNNPCTSTQE	ZFPM2	761	Q8WW38
QDPSNDCNDNQREVR	ILDR1	86	Q86SU0
ASNPIECSQRSAQEL	NFATC1	581	O95644
ANSLDNERCPDARSQ	PACS2	451	Q86VP3
QFSSRCEAPDANQQL	GOLGA2	351	Q08379
NSNLFQCTNPTELDT	MAB21L3	331	Q8N8X9
RTSSDPNLNNHCQEV	MTMR4	626	Q9NYA4
SRTPGNCQNSANEVD	PUM1	296	Q14671
LIQDENDNSPCFEQS	DCHS2	2231	Q6V1P9
KESLNVPQDSDCQNS	NCOA6	1416	Q14686
VPQDSDCQNSQSRKE	NCOA6	1421	Q14686
DDNCTDNFTPNQVAR	PAPPA2	811	Q9BXP8
QELNPETSTDCDARQ	BLM	351	P54132
DALERNSLSSQDPQQ	CRTAM	226	O95727
PLFTQSQESSCDQNA	CEP97	666	Q8IW35
DAVQNFSSERNPCNS	ADCY9	951	O60503
QRQTDETCSLLDQGQ	CEP85L	676	Q5SZL2
NTNTATPFCNRQLSD	EHBP1	841	Q8NDI1
TPFCNRQLSDQQDEE	EHBP1	846	Q8NDI1
DPSSNAEDASCQKNL	C13orf46	71	A0A1B0GUA9
ASLQPVSNQIERCNS	CYLD	546	Q9NQC7
NESERNQEPCSINSD	CEP295	1411	Q9C0D2
CEAPNRLSDLQNVSE	DNAH10	1531	Q8IVF4
DQEPSQVENQSRCDR	RYR1	1056	P21817
SCVPLNTNELNSNEN	CAMSAP2	511	Q08AD1
PQVSEQDSLNNNESC	CNST	61	Q6PJW8
NLQNTLCEASRDEQA	CNST	86	Q6PJW8
PSQDEDRQSNASQTL	PPP6R2	201	O75170
ADEVLDCQSNQNRPD	PRR14L	966	Q5THK1
QSPCQEQAAVLNSRS	GOLGA8A	96	A7E2F4
NNSNPCSASQASQLE	HSF5	416	Q4G112
CLTRKENNLTEDNPN	SENP7	811	Q9BQF6
EDILADAPESQNNCR	STING1	296	Q86WV6
FQNEQDSSCLPRTSQ	TBC1D31	996	Q96DN5
ETQSCPNSLEDNNLQ	SPDL1	486	Q96EA4
DQQCSDTTLAPQDPR	SPPL2C	126	Q8IUH8
ANNPEQNRLSECEEQ	SND1	141	Q7KZF4
ATCSRIESPNENSNN	SP1	66	P08047
QNNSSVDPCMRNLDE	SP140L	391	Q9H930
ATRDNPTTSCAQRDN	TRIOBP	446	Q9H2D6
IQQENPRTSCAQRDD	TRIOBP	691	Q9H2D6
SVENANPSSRDNSCE	SMCR8	631	Q8TEV9
PSCDQTLQEELARQQ	ACTN3	626	Q08043
QQPAEQRPDSCESLS	CFAP20DC	636	Q6ZVT6
ADQQRACPATQALEE	ZBTB25	181	P24278
NSRAVDCQLPTDVQQ	VWDE	986	Q8N2E2
SVTRSNQNNCDPFSL	STIL	1081	Q15468
NNDDNIPNTTSDCRL	ZBTB5	426	O15062
PCQSSSNDEEENNRR	UNC80	161	Q8N2C7
EQAQSCRQQVAPTDD	SPTAN1	951	Q13813
TLNDSNPSLCNSEAE	SETD2	796	Q9BYW2
NLDCNSDSQVFPSLN	TMEM87B	136	Q96K49
LQDNAQCQPNSDTSL	ZNF507	611	Q8TCN5
DLQENFCRNPDSSTT	F2	151	P00734
ASFEPNNTCENSQSR	UBXN4	136	Q92575
QQTDLPECEQSSARQ	TCF25	431	Q9BQ70
CLERPNSASSQNSTD	TULP3	151	O75386
DNPCNDAIANTLNEE	TIPIN	261	Q9BVW5
LQLSSDADNCQNSVP	ZNF804A	316	Q7Z570
NNQHTDLCQSSDPDV	ZBTB6	136	Q15916