Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1F CACHD1 RYR2 CATSPER4 CNGA1 CNGA2

1.02e-041291156GO:0005262
GeneOntologyMolecularFunctionABC-type bile acid transporter activity

ABCC4 ABCB11

1.96e-0441152GO:0015432
GeneOntologyMolecularFunctionATPase-coupled organic acid transmembrane transporter activity

ABCC4 ABCB11

1.96e-0441152GO:0033283
GeneOntologyMolecularFunctionATPase-coupled monocarboxylic acid transmembrane transporter activity

ABCC4 ABCB11

1.96e-0441152GO:0033285
GeneOntologyMolecularFunctionATPase-coupled carboxylic acid transmembrane transporter activity

ABCC4 ABCB11

1.96e-0441152GO:0033284
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1F CACHD1 RYR2 CATSPER4 CNGA1 CNGA2

2.42e-041511156GO:0015085
GeneOntologyMolecularFunctionglucokinase activity

HK1 HK3

3.25e-0451152GO:0004340
GeneOntologyMolecularFunctionhexokinase activity

HK1 HK3

3.25e-0451152GO:0004396
GeneOntologyMolecularFunctionfructokinase activity

HK1 HK3

3.25e-0451152GO:0008865
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

RYR2 AKAP1 ACBD3

3.90e-04251153GO:0034237
GeneOntologyMolecularFunctionintracellularly cGMP-activated cation channel activity

CNGA1 CNGA2

6.78e-0471152GO:0005223
GeneOntologyMolecularFunctionoxo-acid-lyase activity

HMGCL HOGA1

6.78e-0471152GO:0016833
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR2 CNGA1 CNGA2

8.95e-04331153GO:0005217
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

SETD1B SETD4

9.00e-0481152GO:0140945
GeneOntologyMolecularFunctionxenobiotic transmembrane transporter activity

ABCC4 SLC17A3 ABCB11

9.78e-04341153GO:0042910
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1F NDUFS7 SLC17A3 TMEM94 CACHD1 RYR2 SLC30A7 CATSPER4 SLC2A13 CNGA1 CNGA2

9.95e-0462711511GO:0022890
GeneOntologyMolecularFunctionATPase-coupled lipid transmembrane transporter activity

ABCC4 ABCB11

1.15e-0391152GO:0034040
GeneOntologyMolecularFunctionurate transmembrane transporter activity

ABCC4 SLC17A3

1.15e-0391152GO:0015143
GeneOntologyMolecularFunctionsalt transmembrane transporter activity

ABCC4 SLC17A3

1.15e-0391152GO:1901702
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1F ABCC4 NDUFS7 SLC17A3 TMEM94 CACHD1 RYR2 SLC30A7 CATSPER4 SLC2A13 CNGA1 CNGA2

1.42e-0375811512GO:0015318
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

CNGA1 CNGA2

1.44e-03101152GO:0005222
GeneOntologyMolecularFunctionlyase activity

ACO2 HMGCL ADCY3 HOGA1 FH MOCOS

1.44e-032121156GO:0016829
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1F SLC17A3 TMEM94 CACHD1 RYR2 SLC30A7 CATSPER4 CNGA1 CNGA2

1.48e-034651159GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1F NDUFS7 SLC17A3 TMEM94 CACHD1 RYR2 SLC30A7 CATSPER4 SLC2A13 CNGA1 CNGA2

1.57e-0366411511GO:0008324
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1F CACHD1 CATSPER4

2.36e-03461153GO:0005245
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

CNGA1 CNGA2

2.46e-03131152GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

CNGA1 CNGA2

2.46e-03131152GO:0043855
GeneOntologyCellularComponentU2-type spliceosomal complex

U2AF2 XAB2 SNRPGP15 PPIL1 PLRG1 SNRPG

1.68e-05971166GO:0005684
GeneOntologyCellularComponentpole plasm

AGO2 STK31 SNRPGP15 SNRPG

1.92e-05291164GO:0045495
GeneOntologyCellularComponentgerm plasm

AGO2 STK31 SNRPGP15 SNRPG

1.92e-05291164GO:0060293
GeneOntologyCellularComponentP granule

AGO2 STK31 SNRPGP15 SNRPG

1.92e-05291164GO:0043186
GeneOntologyCellularComponentU2-type catalytic step 2 spliceosome

XAB2 PPIL1 PLRG1 SNRPG

2.52e-05311164GO:0071007
GeneOntologyCellularComponentcalcium channel complex

CACNA1F CACHD1 RYR2 MICU1 CATSPER4

5.36e-05731165GO:0034704
GeneOntologyCellularComponentPrp19 complex

U2AF2 XAB2 PLRG1

8.85e-05161163GO:0000974
GeneOntologyCellularComponentU2-type prespliceosome

U2AF2 SNRPGP15 SNRPG

1.28e-04181163GO:0071004
GeneOntologyCellularComponentprespliceosome

U2AF2 SNRPGP15 SNRPG

1.28e-04181163GO:0071010
GeneOntologyCellularComponentnuclear protein-containing complex

TRERF1 ZNF143 SETD1B U2AF2 ZNF217 ADNP FAAP100 CREBBP XAB2 STAT3 SNRPGP15 ZBTB7A PPIL1 DOCK7 NFYC PRKDC ANAPC7 PLRG1 SNRPG

2.00e-04137711619GO:0140513
GeneOntologyCellularComponentcatalytic step 2 spliceosome

XAB2 SNRPGP15 PPIL1 PLRG1 SNRPG

2.07e-04971165GO:0071013
GeneOntologyCellularComponentDNA-dependent protein kinase complex

ZBTB7A PRKDC

3.02e-0451162GO:0070418
GeneOntologyCellularComponentcation channel complex

CACNA1F CACHD1 RYR2 MICU1 CATSPER4 CNGA1 CNGA2

3.43e-042351167GO:0034703
GeneOntologyCellularComponentintracellular cyclic nucleotide activated cation channel complex

CNGA1 CNGA2

6.30e-0471162GO:0017071
GeneOntologyCellularComponentspliceosomal complex

U2AF2 XAB2 SNRPGP15 PPIL1 PLRG1 SNRPG

1.28e-032151166GO:0005681
GeneOntologyCellularComponenttranscription regulator complex

TRERF1 ZNF143 NRF1 SIX4 ADNP CREBBP STAT3 NFYC PKNOX1 PRKDC

1.79e-0359611610GO:0005667
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1F CACHD1 CATSPER4

2.12e-03461163GO:0005891
GeneOntologyCellularComponentU4 snRNP

SNRPGP15 SNRPG

2.29e-03131162GO:0005687
GeneOntologyCellularComponentfascia adherens

TLN2 VCL

2.29e-03131162GO:0005916
GeneOntologyCellularComponentorganelle envelope

NDUFS7 HK1 TMEM176B VPS13C HMGCL ARMC1 STAT3 RYR2 MICU1 GMCL1 GMCL2 GCAT DHFR ALDH18A1 DTX2 AKAP1 PLRG1

2.38e-03143511617GO:0031967
DomainCLZ

CNGA1 CNGA2

2.16e-0441132PF16526
DomainCLZ_dom

CNGA1 CNGA2

2.16e-0441132IPR032406
DomainHexokinase_2

HK1 HK3

3.59e-0451132PF03727
DomainHexokinase_BS

HK1 HK3

3.59e-0451132IPR019807
DomainHexokinase_C

HK1 HK3

3.59e-0451132IPR022673
DomainHexokinase_N

HK1 HK3

3.59e-0451132IPR022672
DomainHexokinase_1

HK1 HK3

3.59e-0451132PF00349
DomainHEXOKINASE_2

HK1 HK3

3.59e-0451132PS51748
DomainHEXOKINASE_1

HK1 HK3

3.59e-0451132PS00378
DomainDUF3398

DOCK8 DOCK7

5.36e-0461132PF11878
DomainHexokinase

HK1 HK3

5.36e-0461132IPR001312
DomainDOCK_C/D_N

DOCK8 DOCK7

5.36e-0461132IPR021816
DomainIon_trans_dom

CACNA1F RYR2 CATSPER4 CNGA1 CNGA2

6.45e-041141135IPR005821
DomainIon_trans

CACNA1F RYR2 CATSPER4 CNGA1 CNGA2

6.45e-041141135PF00520
DomainVinculin/catenin

TLN2 VCL

7.47e-0471132IPR006077
DomainDHR-1_domain

DOCK8 DOCK7

1.93e-03111132IPR027007
DomainDHR_2

DOCK8 DOCK7

1.93e-03111132PS51651
DomainDHR_1

DOCK8 DOCK7

1.93e-03111132PS51650
DomainDHR-2

DOCK8 DOCK7

1.93e-03111132PF06920
DomainDOCK

DOCK8 DOCK7

1.93e-03111132IPR026791
DomainDOCK_C

DOCK8 DOCK7

1.93e-03111132IPR010703
DomainDOCK-C2

DOCK8 DOCK7

1.93e-03111132PF14429
DomainDHR-2

DOCK8 DOCK7

1.93e-03111132IPR027357
DomainMIRO-like

AGAP2 AGAP3

2.71e-03131132IPR013684
DomainRoc

AGAP2 AGAP3

2.71e-03131132PF08477
DomainSugar/inositol_transpt

SLC2A13 SLC2A12

3.15e-03141132IPR003663
DomainTUDOR

STK31 AKAP1

3.15e-03141132PF00567
DomaincNMP-bd_CS

CNGA1 CNGA2

4.12e-03161132IPR018488
DomainSUGAR_TRANSPORT_2

SLC2A13 SLC2A12

4.65e-03171132PS00217
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

ABCC4 NDUFS7 AGO2 NRF1 VPS13C U2AF2 MCCC2 IDE CREBBP ADCY3 DNAH14 MAPK8IP3 MICU1 PHF2 PACS1 ZBTB7A TBC1D1 ANKAR EIF2AK4 GNL3 TBCD MOCOS AGAP3

8.41e-1014891172328611215
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

HK1 VPS13C ACO2 U2AF2 HMGCL MCCC2 IDE ADNP PHF2 SEC11A DOCK7 ALDH18A1 TLN2 PRKDC FH ANAPC7 PLRG1 CLUH GNL3 TOP2B VCL

1.15e-0814251172130948266
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

NDUFS7 ACO2 U2AF2 MCCC2 ADNP XAB2 ERLIN1 STAT3 SNRPGP15 PHF2 DHFR PPIL1 ALDH18A1 GNAI2 PRKDC FH PLRG1 GNL3 TOP2B

8.82e-0813181171930463901
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

NDUFS7 HK1 HK3 ACO2 HMGCL MCCC2 IDE ARMC1 MICU1 CBR4 FSIP2 GCAT HOGA1 ALDH18A1 FH AKAP1

9.18e-089261171620877624
Pubmed

Human transcription factor protein interaction networks.

TRERF1 ZNF143 AGO2 ACO2 ZNF521 ZNF217 MCCC2 SIX4 ADNP CREBBP STAT3 PHF2 ZBTB7A PPIL1 NFYC SPOP GARRE1 GNL3 VCL

3.05e-0714291171935140242
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

NDUFS7 HK1 HK3 ACO2 HMGCL MCCC2 IDE ARMC1 MICU1 CBR4 FSIP2 GCAT HOGA1 ALDH18A1 FH AKAP1

4.75e-0710471171618614015
Pubmed

Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.

NRF1 PRKDC TOP2B

7.37e-076117319181665
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

U2AF2 RNF40 ADNP STAT3 PRKDC PLRG1 GNL3 TOP2B

8.52e-07220117835785414
Pubmed

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

NDUFS7 HK1 ACO2 HMGCL MCCC2 IDE ARMC1 MICU1 CBR4 GCAT HOGA1 DHFR ALDH18A1 FH AKAP1 CLUH

1.38e-0611361171634800366
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TRERF1 NDUFS7 RNF40 ZNF217 MCCC2 ADNP PALB2 DOCK7 KIAA1958 AKAP1

1.61e-064181171034709266
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZSCAN5A U2AF2 RNF40 MCCC2 SIX4 ADNP PALB2 XAB2 PHF2 ZBTB7A PRKDC ANAPC7 PLRG1 SNRPG SPTY2D1 GNL3 TOP2B

1.61e-0612941171730804502
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

IDE FAAP100 XAB2 PACS1 PPIL1 ALDH18A1 TLN2 GNAI2 PRKDC ANAPC7 PLRG1 SNRPG GNL3 TOP2B VCL TBCD

1.71e-0611551171620360068
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

TRERF1 ZNF217 PALB2 MAPK8IP3 PACS1 ZBTB7A KIAA1958 TLN2 PRKDC AKAP1 CLUH TOP2B MOCOS

2.20e-067741171315302935
Pubmed

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

NDUFS7 HK1 NRF1 ACO2 HMGCL MCCC2 GCAT HOGA1 ALDH18A1 FH AKAP1

2.33e-065421171114651853
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NDUFS7 ZNF217 SIX4 XAB2 ERLIN1 EPN2 MICU1 SLC30A7 PHF2 ZBTB7A ZNF277 ALDH18A1 AKAP1 ANAPC7 SNRPG SPTY2D1 GNL3 AGAP3

2.69e-0614971171831527615
Pubmed

Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

XAB2 PPIL1 PLRG1 SNRPG

3.12e-0630117428076346
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NDUFS7 HK1 ACO2 ZNF521 U2AF2 GPC6 ADNP XAB2 PHF2 SEC11A DOCK7 PRKDC PLRG1 SNRPG TOP2B

3.68e-0610821171538697112
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

TRERF1 ZNF143 DOCK8 ZNF217 ADNP CREBBP PALB2 PHF2 PPIL1 KIAA1958 PRKDC ANAPC7 PLRG1 SNRPG TOP2B

4.63e-0611031171534189442
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

U2AF2 ZNF217 MCCC2 ADNP XAB2 ERLIN1 NFYC ALDH18A1 PRKDC PLRG1 SPTY2D1 GNL3 TOP2B VCL

6.28e-069891171436424410
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF521 CRTAC1 RNF40 CACHD1 CREBBP XAB2 STAT3 MAPK8IP3 MICU1 GMCL1 PKNOX1 TLN2 PRKDC ACBD3 AGAP2 AGAP3

6.63e-0612851171635914814
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

ZNF143 NRF1 FAAP100 CREBBP ERLIN1 EPN2 MICU1 PACS1 TBC1D1 DOCK7 ANAPC7 SNRPG CLUH VCL TBCD AGAP3

9.35e-0613211171627173435
Pubmed

Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors.

ABCC4 ABCB11

1.12e-052117225735837
Pubmed

Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling.

STAT3 NOS3

1.12e-052117221611796
Pubmed

Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness.

PRKDC C5

1.12e-052117239262774
Pubmed

Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.

DOCK8 STAT3

1.12e-052117227350570
Pubmed

Mouse germ cell-less as an essential component for nuclear integrity.

GMCL1 GMCL2

1.12e-052117212556490
Pubmed

Integrin-mediated cell adhesion: the cytoskeletal connection.

TLN2 VCL

1.12e-052117210320934
Pubmed

Low expression of AIM2 combined with high expression of p‑STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.

STAT3 AIM2

1.12e-052117230816544
Pubmed

Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin.

TLN2 VCL

1.12e-052117232657269
Pubmed

Incompatibility in cell adhesion constitutes a barrier to interspecies chimerism.

PRKDC C5

1.12e-052117239181131
Pubmed

Isolation of slow-cycling cancer cells from lung patient-derived xenograft using carboxyfluorescein-succinimidyl ester retention-mediated cell sorting.

PRKDC C5

1.12e-052117236924504
Pubmed

Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models.

PRKDC C5

1.12e-052117239047119
Pubmed

Key findings to expedite the diagnosis of hyper-IgE syndromes in infants and young children.

DOCK8 STAT3

1.12e-052117226592211
Pubmed

Global analysis of AGO2-bound RNAs reveals that miRNAs induce cleavage of target RNAs with limited complementarity.

AGO2 PRKDC

1.12e-052117229031931
Pubmed

Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells.

GMCL1 GMCL2

1.12e-052117210448096
Pubmed

Caffeine Supplementation and FOXM1 Inhibition Enhance the Antitumor Effect of Statins in Neuroblastoma.

PRKDC C5

1.12e-052117237057874
Pubmed

Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model.

STAT3 NOS3

1.12e-052117229581793
Pubmed

Successful long-term correction of autosomal recessive hyper-IgE syndrome due to DOCK8 deficiency by hematopoietic stem cell transplantation.

DOCK8 STAT3

1.12e-052117221058221
Pubmed

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants.

PRKDC C5

1.12e-052117231543464
Pubmed

Differential association of STAT3 and HK-II expression in hepatitis B virus- and hepatitis C virus-related hepatocellular carcinoma.

HK1 STAT3

1.12e-052117226889748
Pubmed

Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility.

GMCL1 GMCL2

1.12e-052117215700541
Pubmed

Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern.

DOCK8 STAT3

1.12e-052117224898675
Pubmed

Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma.

STAT3 GNL3

1.12e-052117234785448
Pubmed

Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency.

PRKDC C5

1.12e-052117234702956
Pubmed

An in vivo neuroimmune organoid model to study human microglia phenotypes.

PRKDC C5

1.12e-052117237172564
Pubmed

Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut-kidney axis.

STAT3 C5

1.12e-052117233280239
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

AGO2 HK1 SETD1B ACO2 U2AF2 MCCC2 ADNP CREBBP ERLIN1 ALDH18A1 GNAI2 PRKDC PLRG1 GNL3 TOP2B VCL

1.26e-0513531171629467282
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

ADNP FAAP100 XAB2 ERLIN1 PPIL1 ALDH18A1 GNAI2 PRKDC PLRG1 GNL3 TOP2B

1.33e-056521171131180492
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

HK1 U2AF2 RNF40 MCCC2 XAB2 STAT3 DOCK7 ALDH18A1 PRKDC PLRG1 GNL3

1.35e-056531171133742100
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

HK1 U2AF2 ADNP XAB2 DOCK7 ALDH18A1 PRKDC FH CLUH GNL3 VCL

1.35e-056531171122586326
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

AGO2 U2AF2 ITIH3 XAB2 ERLIN1 STAT3 SNRPGP15 PHF2 PPIL1 DOCK7 ALDH18A1 EIF2AK4 C5 PLRG1 SPTY2D1 GNL3

1.48e-0513711171636244648
Pubmed

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.

GMCL1 GMCL2 PRKDC

1.64e-0515117317010969
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

NDUFS7 AGO2 ACO2 U2AF2 ZNF217 MCCC2 ERLIN1 ALDH18A1 GNAI2 PRKDC FH ACBD3 PLRG1 GNL3 VCL

1.97e-0512471171527684187
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

AGO2 HK1 RNF40 MCCC2 ERLIN1 GCAT SEC11A DHFR ALDH18A1 PRKDC ACBD3 ANAPC7 PLRG1 GNL3 TBCD

2.16e-0512571171537317656
Pubmed

NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.

NRF1 CREBBP VCL

2.44e-0517117334637754
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

HK1 ACO2 SPEF2 U2AF2 HMGCL STK31 PALB2 ERLIN1 RYR2 KRT73 GNAI2 EIF2AK4 PRKDC ANAPC7 TOP2B AGAP2

2.73e-0514421171635575683
Pubmed

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.

ZNF217 ADNP CREBBP NFYC ALDH18A1 PRKDC

3.23e-05178117627637333
Pubmed

Functional proteomics mapping of a human signaling pathway.

DOCK8 U2AF2 CREBBP XAB2 RYR2 EPN2 TBC1D1 ACBD3 VCL TBCD

3.26e-055911171015231748
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

HK1 ACO2 RNF40 ALDH18A1 PRKDC VCL

3.33e-05179117636261009
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ZNF143 HK3 NRF1 SIX4 ADNP FAAP100 CREBBP STAT3 DHFR NFYC ANAPC7 TOP2B

3.34e-058571171225609649
Pubmed

[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].

HK1 HK3

3.36e-053117226855992
Pubmed

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

CREBBP STAT3

3.36e-053117215649887
Pubmed

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes.

RYR2 NOS3

3.36e-053117218077344
Pubmed

Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.

CREBBP STAT3

3.36e-053117210764767
Pubmed

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.

PRKDC C5

3.36e-053117237084714
Pubmed

G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.

PRKDC C5

3.36e-053117235767962
Pubmed

Clinical manifestations of hyper IgE syndromes.

DOCK8 STAT3

3.36e-053117221178271
Pubmed

Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.

CNGA1 CNGA2

3.36e-05311727532814
Pubmed

Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling.

DHFR NOS3

3.36e-053117223707606
Pubmed

Vinculin and talin: focus on the myocardium.

TLN2 VCL

3.36e-053117219952892
Pubmed

Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice.

PRKDC C5

3.36e-053117217967861
Pubmed

Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.

GMCL1 GMCL2

3.36e-05311729878064
Pubmed

Mechanosensing through YAP controls T cell activation and metabolism.

PRKDC C5

3.36e-053117232484502
Pubmed

Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.

TLN2 VCL

3.36e-053117227816808
Pubmed

Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans.

PRKDC C5

3.36e-053117236692963
Pubmed

TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes.

VPS13C TBC1D1

3.36e-053117233087848
Pubmed

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

TLN2 VCL

3.36e-053117215494027
Pubmed

Vinculin controls talin engagement with the actomyosin machinery.

TLN2 VCL

3.36e-053117226634421
Pubmed

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.

STAT3 AGAP2

3.36e-053117234411567
Pubmed

A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression.

TRERF1 CREBBP

3.36e-053117211349124
Pubmed

Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.

CNGA1 CNGA2

3.36e-053117212649326
Pubmed

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties.

PRKDC C5

3.36e-053117230074477
Pubmed

Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells.

PRKDC C5

3.36e-053117239137728
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

VPS13C U2AF2 ERLIN1 STAT3 PRKDC GNL3 TOP2B

3.60e-05268117733024031
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

HK1 ACO2 U2AF2 MCCC2 ALDH18A1 FH PLRG1 CLUH VCL TBCD

4.08e-056071171039147351
Pubmed

Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.

PKNOX1 PRKDC ANAPC7

5.45e-0522117331839203
Pubmed

The functional interactome landscape of the human histone deacetylase family.

TRERF1 ZNF521 ZNF217 MCCC2 ADNP XAB2 PRKDC

5.79e-05289117723752268
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

HK1 VPS13C U2AF2 MCCC2 RYR2 DOCK7 ALDH18A1 PRKDC AKAP1 SPTY2D1 AGAP3

6.54e-057771171135844135
Pubmed

Simultaneous Loss of NCKX4 and CNG Channel Desensitization Impairs Olfactory Sensitivity.

ADCY3 CNGA2

6.70e-054117228053034
Pubmed

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.

HK1 HK3

6.70e-054117225904018
Pubmed

Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.

ZSCAN5A ZSCAN5C

6.70e-054117231155506
Pubmed

Vinculin regulates assembly of talin: β3 integrin complexes.

TLN2 VCL

6.70e-054117224446374
Pubmed

Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.

PRKDC C5

6.70e-054117220033053
Pubmed

Involvement of telomerase reverse transcriptase in heterochromatin maintenance.

AGO2 GNL3

6.70e-054117224550003
Pubmed

Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.

NRF1 IDE

6.70e-054117223525105
Pubmed

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma.

PRKDC C5

6.70e-054117231484063
Pubmed

Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.

DHFR NOS3

6.70e-054117226381869
Pubmed

Platelet-endothelial cell adhesion molecule-1 regulates endothelial NO synthase activity and localization through signal transducers and activators of transcription 3-dependent NOSTRIN expression.

STAT3 NOS3

6.70e-054117221183735
Pubmed

High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.

HK1 HK3

6.70e-054117225766729
Pubmed

Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

GMCL1 GMCL2

6.70e-054117212927808
GeneFamilyCyclic nucleotide gated channels

CNGA1 CNGA2

5.45e-0410642250
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP2 AGAP3

1.62e-03176421291
CoexpressionDIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP

ABCC4 HK1 ACO2 U2AF2 ZNF217 MCCC2 IDE STAT3 MICU1 GMCL1 ZNF277 SEC11A ALDH18A1 SPOP PRKDC FH AKAP1 ACBD3 SNRPG GNL3 VCL

8.01e-07139911621M535
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_NONRESPONDER_28DY_UP

ABCC4 TAPT1 ARMC1 CLN5 ACBD3 SNRPG TOP2B

1.28e-051741167M40888
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

SETD1B ADNP CREBBP PHF2 ZBTB7A NFYC PKNOX1 SPOP

2.80e-0617311584665_DN
DiseaseC-reactive protein measurement

TRERF1 VPS13C SETD4 CRTAC1 CACHD1 ADCY3 STAT3 MAPK8IP3 MICU1 OR2B11 PACS1 TBC1D1 DOCK7 ABCB11 GNAI2 AIM2 TOP2B

3.45e-06120611317EFO_0004458
DiseaseCardiac arrhythmia

RYR2 GNAI2

1.45e-0521132cv:C0003811
DiseaseGenetic cardiac rhythm disease

RYR2 GNAI2

1.45e-0521132cv:C5681782
DiseaseHyper-Immunoglobulin E Syndrome, Autosomal Recessive

DOCK8 STAT3

4.35e-0531132C1968689
DiseaseHyper-Immunoglobulin E Syndrome, Autosomal Dominant

DOCK8 STAT3

4.35e-0531132C2936739
Diseaseacute lymphoblastic leukemia (is_implicated_in)

HK1 CREBBP DHFR NOS3

5.98e-05551134DOID:9952 (is_implicated_in)
DiseaseJob Syndrome

DOCK8 STAT3

8.68e-0541132C3887645
DiseasePancytopenia

PALB2 DHFR MOCOS

1.33e-04261133C0030312
Diseasefasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement

VPS13C ABCB11

1.44e-0451132EFO_0004307, EFO_0004465, EFO_0004466
DiseaseFamilial ventricular tachycardia

RYR2 GNAI2

1.44e-0451132C0340485
DiseaseAbnormal muscle tone

HK1 MAPK8IP3

2.16e-0461132C0852413
DiseaseMalignant neoplasm of breast

TRERF1 HK3 ACO2 SIX4 PALB2 STAT3 ZNF277 DHFR NFYC GNAI2 CNGA2 NOS3 AGAP2

2.43e-04107411313C0006142
Diseaseneutropenia (implicated_via_orthology)

STAT3 C5

3.01e-0471132DOID:1227 (implicated_via_orthology)
DiseaseColorectal Carcinoma

ABCC4 HK3 ZSCAN5A SETD4 ZNF217 KRT73 GMCL2 DHFR PKNOX1 ABCB11

3.75e-0470211310C0009402
Diseasecystic fibrosis (implicated_via_orthology)

ABCC4 ABCB11

5.14e-0491132DOID:1485 (implicated_via_orthology)
DiseaseTachycardia, Ventricular

RYR2 NOS3

7.82e-04111132C0042514
Diseasecholestasis (biomarker_via_orthology)

ABCC4 ABCB11 NOS3

8.86e-04491133DOID:13580 (biomarker_via_orthology)
Diseaselymphangioleiomyomatosis (is_marker_for)

STAT3 NOS3

9.36e-04121132DOID:3319 (is_marker_for)
Diseaseacute myeloid leukemia (implicated_via_orthology)

CREBBP TOP2B

9.36e-04121132DOID:9119 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

HK1 CREBBP ALDH18A1 PRKDC SNRPG

1.20e-032061135C0152013
Diseaseeating disorder, bipolar disorder

RYR2 AIM2

1.28e-03141132EFO_0005203, MONDO_0004985
DiseaseSquamous cell carcinoma

DOCK8 CREBBP STAT3 PRKDC

1.34e-031241134C0007137
DiseaseDiabetic Angiopathies

ADCY3 NOS3

1.68e-03161132C0011875
DiseaseMicroangiopathy, Diabetic

ADCY3 NOS3

1.68e-03161132C0025945
DiseaseIntellectual Disability

HK1 DOCK8 TMEM94 HMGCL MAPK8IP3 PACS1 TBCD

1.70e-034471137C3714756
Diseaseobsolete_red blood cell distribution width

AGO2 HK1 SETD1B NRF1 DOCK8 ZNF217 MICU1 GMCL1 ABCB11 EIF2AK4 CLUH GARRE1 GNL3

1.96e-03134711313EFO_0005192
DiseaseMyeloid Leukemia

AGO2 TOP2B

2.14e-03181132C0023470
DiseaseLeukemia, Monocytic, Chronic

AGO2 TOP2B

2.14e-03181132C0023466
DiseaseDisorder of organic acid metabolism

HMGCL MCCC2

2.14e-03181132cv:C1263739
DiseaseProstatic Neoplasms

ABCC4 CREBBP PALB2 STAT3 ZBTB7A SPOP PRKDC NOS3

2.59e-036161138C0033578
DiseaseMalignant neoplasm of prostate

ABCC4 CREBBP PALB2 STAT3 ZBTB7A SPOP PRKDC NOS3

2.59e-036161138C0376358
Diseasepulse pressure measurement

FAT3 CRTAC1 ITIH3 STAT3 ZBTB7A GCAT PPIL1 ABCB11 TLN2 EIF2AK4 SLC2A13 GARRE1 VCL

2.61e-03139211313EFO_0005763
DiseaseAdenocarcinoma of prostate

PALB2 SPOP

2.64e-03201132C0007112
Diseaseautism spectrum disorder

DOCK8 ITIH3 ZNF600 CCDC102B

3.10e-031561134EFO_0003756
DiseaseLung diseases

DOCK8 STAT3 PRKDC

3.38e-03781133C0024115
Diseasepulmonary hypertension (biomarker_via_orthology)

HK1 RYR2 NOS3

3.63e-03801133DOID:6432 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ATAQMAMLQFISSGL

ACO2

101

Q99798
KPNLNSTGVNMMSSV

ADNP

311

Q9H2P0
LAVMTAMGNALANSV

AGAP3

691

Q96P47
QGGQITLSMQKFEML

RNF40

321

O75150
MSEMTGNTALLAQVT

AKAP1

846

Q92667
IKIMSMQGQITDSNI

AMN1

41

Q8IY45
VTTNLEQMMKAGEQG

CATSPER4

306

Q7RTX7
VVSVGQMSMSRAINL

EIF2AK4

1401

Q9P2K8
LMIQNAGAVSAVMKT

AIM2

51

O14862
MNMTQARVLVAAVVG

ERLIN1

1

O75477
GMMLSLQNVIQKTTT

ARMC1

81

Q9NVT9
NVPNMSQMQTSVGIV

CREBBP

321

Q92793
GSMMVLNQLSNLETT

CACHD1

421

Q5VU97
IGMIVNSFTNVTVAM

ABCB11

876

O95342
ASINGLVKDMSTVQM

AGAP2

751

Q99490
GDTVLGMATQCVQMK

AGO2

536

Q9UKV8
GMATQCVQMKNVQRT

AGO2

541

Q9UKV8
VMKQLIGSSNLFVMQ

GMCL1

256

Q96IK5
QGLLSGVAQMKDMVT

GON7

31

Q9BXV9
SSVMAASLVTMGIVN

SLC2A12

351

Q8TD20
SVSGNMIIIMLTLSN

OR6C65

36

A6NJZ3
IMSQMNNVGFSTAIL

ANKAR

71

Q7Z5J8
KGAEVASMTMNVIQT

ANAPC7

181

Q9UJX3
MQMFGKVALQDGTQI

CACNA1F

1346

O60840
NVIMNITMVAMVNST

SLC17A3

56

O00476
QATVEMTVSMAQVGA

HOGA1

116

Q86XE5
VNFMRMKSQTEGSIQ

MAGEE2

96

Q8TD90
MKSQTEGSIQQSEML

MAGEE2

101

Q8TD90
NSVSISVINSSMAGM

KRT73

451

Q86Y46
VTQEMRNVSIGMGSS

MAPK8IP3

321

Q9UPT6
MSSKNIAQIAVVMGS

MCCC2

201

Q9HCC0
VQQALAGMTSVLMSA

DTX2

331

Q86UW9
KERMAQVATGMGSNQ

EPN2

151

O95208
VLSSINAIMKSGMIN

FSIP2

5491

Q5CZC0
MAGASLDKVTMQQVA

MICU1

386

Q9BPX6
AMNSIVMETGNTKNS

PLRG1

161

O43660
MFMAVQALNGQQTLS

GUCA1C

116

O95843
AASQEMQQGATVTMA

NRF1

391

Q16656
MQQGATVTMALNSEA

NRF1

396

Q16656
TVPSNMMSVNGQAKT

ACBD3

326

Q9H3P7
VGMRNVTMAINVIST

MOCOS

156

Q96EN8
DLLMGSNTIVQSMAA

GCAT

311

O75600
GRMQTMVTEQATQGS

FAAP100

806

Q0VG06
ANIVAVVNDTVGTMM

HK1

201

P19367
NVVAIVNDTVGTMMS

HK3

656

P52790
QSGTGQTMQVMQQII

NFYC

216

Q13952
EAQLSGTMAMTVVTK

PACS1

866

Q6VY07
QNQGREMMLVTSGAV

ALDH18A1

106

P54886
NAVKISASLMGTVMA

NOS3

501

P29474
MFVCGDVTMATNVLQ

NOS3

1111

P29474
TVPQMLVNMGSSQKT

OR2B11

81

Q5JQS5
KVTLEAMNTTVMQGF

P2RY13

16

Q9BPV8
GMQEALLGTTIMNNI

PALB2

1021

Q86YC2
LSNMAMGKTTTGQIV

ABCC4

181

O15439
MQENSMQVSAKVFQG

GPC6

326

Q9Y625
IGNNFARVKMQVTMS

DOCK7

1586

Q96N67
KMLQMVLQGSVGATV

DOCK8

1971

Q8NF50
TMVAAQVMGNHVAVT

FH

381

P07954
AMQNTMLINGIAQVT

C5

286

P01031
MVGSLNCIVAVSQNM

DHFR

1

P00374
TAMVTEQKAGAMQPQ

GARRE1

676

O15063
IQATNMAGMASNATV

FAT3

1741

Q8TDW7
MAGMASNATVNIQIV

FAT3

1746

Q8TDW7
KAAMRTMIQQQGGSI

CBR4

116

Q8N4T8
NTVNVASRMESTGVM

ADCY3

1066

O60266
ASRMESTGVMGNIQV

ADCY3

1071

O60266
GTQVSTAMEMIQTLS

DNAH14

866

Q0VDD8
NVGVSMGLTRSMQVV

GNL3

281

Q9BVP2
KMVSRNVASGEMNSV

CRTAC1

511

Q9NQ79
GNITKQAALGIMQMV

IDE

731

P14735
GKQMVDMLVESSNNV

RYR2

3996

Q92736
ANQRAIVSMCQIMTT

CCDC184

81

Q52MB2
FQMQQSSIKSRGDMV

CCDC102B

16

Q68D86
GLQMFQQLSGINTIM

SLC2A13

331

Q96QE2
GLTGVEMQTMQRLTN

SPEF2

111

Q9C093
TQVNFMASQMLKVSG

XAB2

736

Q9HCS7
TQEAIQGMLSMANLQ

PHF2

791

O75151
MMTIVNLAQNFVGSN

TOP2B

786

Q02880
LSSDGATLAVQQVMM

PKNOX1

386

P55347
ATLAVQQVMMAGQSE

PKNOX1

391

P55347
DTVTVTQDGLSMMIN

ITIH3

746

Q06033
ALANTLMALQMGVSV

HMGCL

241

P35914
LMALQMGVSVVDSSV

HMGCL

246

P35914
NTIQSIMAIVKAMGN

GNAI2

76

P04899
VMKQLIGSSNLFVMQ

GMCL2

256

Q8NEA9
GLMSQTSLQEGQMII

SETD4

61

Q9NVD3
MSSNIVSNGISMTDI

SIX4

396

Q9UIU6
QMQTQVLSRLMTGQG

SETD1B

776

Q9UPS6
QSDVMIVAGTLTNKM

NDUFS7

116

O75251
NIISRSSNGQMNGMK

SPTY2D1

546

Q68D10
MTQNTVIVNGVAMAS

TMEM176B

1

Q3YBM2
LVQVATISGNMFNQM

CLN5

181

O75503
ATIVGNIGSMISNMN

CNGA1

386

P29973
TIVGNVGSMISNMNA

CNGA2

366

Q16280
SNQQKAVLMSERVMG

CLUH

1041

O75153
TKSVSQRASVNMMVG

STK31

876

Q9BXU1
ISQADMQAIGNTITM

ZNF143

511

P52747
MQAIGNTITMVTQDG

ZNF143

516

P52747
VEMATSGQQNNIGMV

SNRPG

46

P62308
IGMVNRVGMVETNSQ

PPIL1

136

Q9Y3C6
QALSGQIFMGMVSSQ

TMEM94

816

Q12767
DSVNISGQNTMNMVK

SPOP

166

O43791
ILGTNTKVMNMEESN

STAT3

386

P40763
AIEQTSLKMMQAVGG

ZNF521

611

Q96K83
VEMATSGQQKNIGMV

SNRPGP15

46

A8MWD9
IGEMKQTSQMAAENI

TBC1D1

466

Q86TI0
MANIQPQMLVAGATS

VCL

741

P18206
QVLVMMNGVQSCKDL

ZSCAN5A

101

Q9BUG6
QSMTDMLLKVQNAIG

TTC41P

851

Q6P2S7
QMAIHISSGNTMNIT

VPS13C

2376

Q709C8
LMIVSMVSAGVLNSS

ERVK-8

81

P61575
QVLNFGMIVSSALMI

SEC11A

21

P67812
SVDNTKMVSAVLNGM

PRKDC

1586

P78527
LGSIGVIASAIMMQN

SLC30A7

246

Q8NEW0
MAASKTQGAVARMQE

ZNF277

1

Q9NRM2
VTLQVPGLMSSQVQM

U2AF2

356

P26368
NNSNMVGTVLMLFLI

XKR3

296

Q5GH77
QALMGTINTSMHAVQ

TLN2

496

Q9Y4G6
MQSKVTGNMPTQSLL

ZNF217

1

O75362
TIMMSNNFVEIKGSV

TAPT1

276

Q6NXT6
LARSSFQTMQGVITM

TBCD

236

Q9BTW9
FQTMQGVITMDGTLQ

TBCD

241

Q9BTW9
MMKEVLSTGQGNTEV

ZNF600

1

Q6ZNG1
QVLVMMNGVQSCKDL

ZSCAN5C

101

A6NGD5
VDGLAASTLLQQMMS

ZBTB7A

311

O95365
NMAQVLHTQSAVMDG

TRERF1

161

Q96PN7
GTNQQVAMQMPVSTS

KIAA1958

301

Q8N8K9