Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphorbol ester receptor activity

UNC13B UNC13C

3.53e-062382GO:0001565
GeneOntologyMolecularFunctionnon-kinase phorbol ester receptor activity

UNC13B UNC13C

3.53e-062382GO:0001566
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC6A9 COX15 CHRNA6 SLC17A3 KCNK7 SLC20A2 SLC45A4 PKD1

2.90e-05664388GO:0008324
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC6A9 SLC17A3 SLC20A2 SLC45A4

7.57e-05119384GO:0015294
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC6A9 COX15 CHRNA6 SLC17A3 KCNK7 SLC20A2 SLC45A4 PKD1

1.01e-04793388GO:0015075
GeneOntologyMolecularFunctiontransporter activity

SLC6A9 XKR8 COX15 CHRNA6 SLC17A3 KCNK7 ABCA13 SLC20A2 SLC45A4 PKD1

1.08e-0412893810GO:0005215
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC6A9 COX15 SLC17A3 KCNK7 SLC20A2 SLC45A4 PKD1

1.57e-04627387GO:0022890
GeneOntologyMolecularFunctionsymporter activity

SLC6A9 SLC17A3 SLC20A2 SLC45A4

1.85e-04150384GO:0015293
GeneOntologyMolecularFunctionsodium:phosphate symporter activity

SLC17A3 SLC20A2

2.30e-0412382GO:0005436
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC6A9 COX15 SLC17A3 SLC20A2 SLC45A4

2.51e-04301385GO:0022853
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC6A9 COX15 SLC17A3 ABCA13 SLC20A2 SLC45A4

2.60e-04477386GO:0022804
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC6A9 COX15 CHRNA6 SLC17A3 KCNK7 ABCA13 SLC20A2 SLC45A4 PKD1

2.92e-041180389GO:0022857
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13B UNC13C

4.16e-0416382GO:0019992
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC6A9 SLC17A3 SLC20A2

4.90e-0481383GO:0015370
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC6A9 COX15 SLC17A3 KCNK7 SLC20A2 SLC45A4 PKD1

4.99e-04758387GO:0015318
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC17A3 SLC20A2

9.48e-0424382GO:0005315
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B UNC13C

9.48e-0424382GO:0017075
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC6A9 SLC17A3 KCNK7 SLC20A2 PKD1

1.79e-03465385GO:0046873
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC6A9 SLC17A3 SLC20A2 SLC45A4

2.35e-03296384GO:0015291
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC6A9 SLC17A3 SLC20A2

4.18e-03171383GO:0015081
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC6A9 UBR3 COX15 CHRNA6 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

3.42e-0611153811GO:0034220
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC6A9 UBR3 COX15 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

4.58e-069223810GO:0098662
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC6A9 UBR3 COX15 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

5.54e-069423810GO:0098655
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC6A9 UBR3 COX15 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

1.09e-0510173810GO:0098660
GeneOntologyBiologicalProcessdense core granule priming

UNC13B UNC13C

1.98e-054382GO:0061789
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC6A9 UBR3 COX15 CHRNA6 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

2.48e-0513743811GO:0006811
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC6A9 UBR3 COX15 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

3.31e-0511573810GO:0006812
GeneOntologyBiologicalProcessnegative regulation of synaptic plasticity

UNC13B UNC13C

4.93e-056382GO:0031914
GeneOntologyBiologicalProcessmetal ion transport

SLC6A9 UBR3 SLC17A3 KCNK7 SLC20A2 AP3D1 STIMATE GP1BA PKD1

6.52e-051000389GO:0030001
GeneOntologyBiologicalProcessmitocytosis

TSPAN9 PKD1

9.19e-058382GO:0160040
GeneOntologyBiologicalProcessmigracytosis

TSPAN9 PKD1

9.19e-058382GO:0140495
GeneOntologyBiologicalProcesspresynaptic dense core vesicle exocytosis

UNC13B UNC13C

1.47e-0410382GO:0099525
GeneOntologyBiologicalProcessneuronal dense core vesicle exocytosis

UNC13B UNC13C

2.16e-0412382GO:0099011
GeneOntologyBiologicalProcessdense core granule exocytosis

UNC13B UNC13C

3.42e-0415382GO:1990504
GeneOntologyBiologicalProcesssynaptic vesicle docking

UNC13B UNC13C

4.42e-0417382GO:0016081
GeneOntologyBiologicalProcessestablishment of organelle localization

UNC13B UNC13C AP3D1 TSPAN9 AURKB PKD1

4.50e-04546386GO:0051656
GeneOntologyCellularComponentmigrasome

TSPAN9 PKD1

1.21e-049392GO:0140494
DomainTetraspanin

CD53 TSPAN16 TSPAN9 UPK1B

5.60e-0732394IPR000301
DomainTetraspanin_EC2

CD53 TSPAN16 TSPAN9 UPK1B

5.60e-0732394IPR008952
DomainTetraspannin

CD53 TSPAN16 TSPAN9 UPK1B

6.36e-0733394PF00335
DomainTetraspanin/Peripherin

CD53 TSPAN16 TSPAN9 UPK1B

6.36e-0733394IPR018499
DomainUnc-13

UNC13B UNC13C

1.27e-053392IPR027080
DomainTM4_1

CD53 TSPAN16 TSPAN9

2.12e-0526393PS00421
DomainMunc13_dom-2

UNC13B UNC13C

4.23e-055392IPR014772
DomainMembr_traf_MHD

UNC13B UNC13C

4.23e-055392PF10540
DomainDMAP_binding

DIP2C DIP2B

4.23e-055392PF06464
DomainDUF1041

UNC13B UNC13C

4.23e-055392SM01145
DomainMHD2

UNC13B UNC13C

4.23e-055392PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13C

4.23e-055392IPR019558
DomainDMAP_binding

DIP2C DIP2B

6.34e-056392SM01137
DomainDMAP1-bd

DIP2C DIP2B

6.34e-056392IPR010506
DomainDUF1041

UNC13B UNC13C

8.86e-057392PF06292
DomainMunc13_1

UNC13B UNC13C

8.86e-057392IPR014770
DomainCAPS_dom

UNC13B UNC13C

8.86e-057392IPR010439
DomainMHD1

UNC13B UNC13C

8.86e-057392PS51258
DomainEamA_dom

SLC35G5 SLC35G3

3.81e-0414392IPR000620
DomainEamA

SLC35G5 SLC35G3

3.81e-0414392PF00892
DomainTetraspanin_CS

CD53 TSPAN9

8.70e-0421392IPR018503
DomainCys-rich_flank_reg_C

LRRC15 GP1BA PKD1

8.72e-0490393IPR000483
DomainLRRCT

LRRC15 GP1BA PKD1

8.72e-0490393SM00082
DomainLRRNT

LRRC15 GP1BA PKD1

1.12e-0398393IPR000372
DomainLRRNT

LRRC15 GP1BA PKD1

1.12e-0398393SM00013
DomainAMP-binding

DIP2C DIP2B

1.78e-0330392PF00501
DomainAMP-dep_Synth/Lig

DIP2C DIP2B

1.78e-0330392IPR000873
DomainLRR_8

LRRC15 GP1BA PKD1

5.41e-03171393PF13855
DomainLRRNT

GP1BA PKD1

5.47e-0353392PF01462
DomainLeu-rich_rpt_typical-subtyp

LRRC15 GP1BA PKD1

5.95e-03177393IPR003591
DomainLRR_TYP

LRRC15 GP1BA PKD1

5.95e-03177393SM00369
DomainC1_1

UNC13B UNC13C

6.31e-0357392PF00130
DomainZF_DAG_PE_1

UNC13B UNC13C

7.89e-0364392PS00479
DomainZF_DAG_PE_2

UNC13B UNC13C

7.89e-0364392PS50081
DomainC1

UNC13B UNC13C

8.13e-0365392SM00109
DomainPE/DAG-bd

UNC13B UNC13C

8.38e-0366392IPR002219
DomainLRR

LRRC15 GP1BA PKD1

8.44e-03201393PS51450
DomainC_TYPE_LECTIN_1

LY75 PKD1

1.21e-0280392PS00615
DomainLectin_C

LY75 PKD1

1.33e-0284392PF00059
DomainCLECT

LY75 PKD1

1.33e-0284392SM00034
DomainC_TYPE_LECTIN_2

LY75 PKD1

1.36e-0285392PS50041
DomainC-type_lectin-like

LY75 PKD1

1.39e-0286392IPR001304
Pubmed

Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.

UNC13B UNC13C

1.23e-06239222674279
Pubmed

Widespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase.

GP1BA AURKB

1.23e-06239220157117
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

CD53 TSPAN9 UPK1B

2.60e-062439311739647
Pubmed

CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.

DIP2C DIP2B

3.67e-06339217236128
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13B UNC13C

3.67e-06339223658173
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13C

3.67e-06339233105896
Pubmed

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.

UNC13B UNC13C

3.67e-06339222966208
Pubmed

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.

UNC13B UNC13C

3.67e-06339215988013
Pubmed

RT-PCR of fatty acid elongases.

SLC35G5 SLC35G3

7.34e-0643929056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G5 SLC35G3

7.34e-06439217101974
Pubmed

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.

UNC13B UNC13C

1.22e-05539234706221
Pubmed

Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation.

AURKB PKD1

1.22e-05539221041232
Pubmed

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

UNC13B UNC13C

1.22e-05539226575293
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

UNC13B UNC13C

2.56e-05739236398873
Pubmed

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

UNC13B UNC13C

3.42e-05839225609709
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

UNC13B UNC13C

6.70e-051139234767769
Pubmed

Chromosomal localization of uroplakin genes of cattle and mice.

GPI UPK1B

8.03e-05123928281015
Pubmed

FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.

NOTCH2 AURKB

1.27e-041539231285543
Pubmed

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

TCF20 NOTCH2

2.54e-042139218591388
Pubmed

Underlying genetic models of inheritance in established type 2 diabetes associations.

TCF20 NOTCH2

2.54e-042139219602701
Pubmed

Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study.

TCF20 NOTCH2

3.05e-042339219720844
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

UNC13B UNC13C

3.91e-042639217124501
Pubmed

Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development.

LY75 NOTCH2

3.91e-042639232467237
Pubmed

Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.

DIP2C DIP2B

4.55e-042839231600191
Pubmed

Obesity and diabetes genetic variants associated with gestational weight gain.

TCF20 NOTCH2

4.88e-042939220816152
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

DIP2C AP3D1 TSPAN9

5.47e-0414239319851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

DIP2C AP3D1 TSPAN9

5.58e-0414339320198315
Pubmed

The synaptic vesicle cycle.

UNC13B UNC13C

5.58e-043139215217342
Pubmed

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors.

NOTCH2 PKD1

7.54e-043639225715395
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

SLC20A2 NOTCH2 STIMATE SLC45A4 PKD1

1.04e-0369739528298427
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

SLC6A9 TCF20 NOTCH2

1.09e-0318039335198878
Cytoband8p11.21

CHRNA6 SLC20A2

1.46e-04213928p11.21
CytobandEnsembl 112 genes in cytogenetic band chr8p11

CHRNA6 SLC20A2

3.50e-03103392chr8p11
GeneFamilyCD molecules|Tetraspanins

CD53 TSPAN16 TSPAN9 UPK1B

1.83e-0733284768
GeneFamilyUNC13 homologs

UNC13B UNC13C

1.39e-054282836
GeneFamilySolute carriers

SLC35G5 SLC6A9 SLC17A3 SLC20A2 SLC35G3 SLC45A4

2.62e-05395286752
GeneFamilyG protein-coupled receptors, Class A orphans

GPR78 GPR75

6.46e-0378282262
GeneFamilyADAM metallopeptidase domain containing|CD molecules

CD53 LY75 GP1BA

2.25e-02394283471
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B CHRNA6 UNC13C NOTCH2

9.23e-05195364DOID:1574 (implicated_via_orthology)
DiseaseGastro-enteropancreatic neuroendocrine tumor

CD53 NOTCH2

1.50e-0415362C2930967
Diseaseneutrophil count

UNC13C TSPAN16 LY75 AP3D1 TSPAN9 NOTCH2 SLC45A4 PKD1

2.12e-041382368EFO_0004833
Diseasebrain cancer (implicated_via_orthology)

NOTCH2 AURKB

4.62e-0426362DOID:1319 (implicated_via_orthology)
Diseasebone mineral content measurement

CD53 DIP2C SNN

5.36e-04130363EFO_0007621
Diseasehematocrit

SLC17A3 SLC20A2 AP3D1 TSPAN9 STIMATE AURKB

1.29e-031011366EFO_0004348
Diseasegut microbiome measurement, taxonomic microbiome measurement

ABCA13 TSPAN9

2.96e-0366362EFO_0007874, EFO_0007883
Diseasewhite matter lesion progression measurement

GPR78 TSPAN9

3.41e-0371362EFO_0007746
Diseasetemporal horn of lateral ventricle volume measurement

GPR78 DIP2C

3.51e-0372362EFO_0010333

Protein segments in the cluster

PeptideGeneStartEntry
FNLLFWICGCCILGF

CD53

16

P19397
WICGCCILGFGIYLL

CD53

21

P19397
NSSIWGGLQGLLCYC

ABCA13

521

Q86UQ4
VLLGGCYNGQIACWD

DNAI2

231

Q9GZS0
NGICEVLYAAAWICG

AP3D1

476

O14617
GGLSGYKCLCDAGWV

NOTCH2

736

Q04721
FYIFGGVGCVCCLLW

SLC17A3

156

O00476
CGKLVSFCWLIGFLG

OR11H4

151

Q8NGC9
WYFLGLGCLEGQTVG

MPV17L2

116

Q567V2
WGLQGDCSLLGAVYF

KCNK7

191

Q9Y2U2
ALPACCYLGDFLVWQ

PDE3B

156

Q13370
AICLDPYCGLGFALW

DIP2B

1196

Q9P265
PYCGLGFALWCLCSV

DIP2B

1201

Q9P265
CDAGWLPNNGFCYLL

LY75

361

O60449
ALLGIWYINCFGCET

GPI

321

P06744
RYAGLLLGCAWGQSL

GPR78

121

Q96P69
KVLWCLQYIGLGFFC

GPR75

386

O95800
GQGFLHGGLCLWLCV

CHRNA6

6

Q15825
DPYCGLGFVLWCLCS

DIP2C

1181

Q9Y2E4
CCLLPLGFYVLGLFW

GP1BA

526

P07359
ALCGLVCFQGLLGWY

COX15

186

Q7KZN9
LLFYGGVGICTGLWV

SLC20A2

536

Q08357
CFYEIICIWGAGGAT

FAM8A1

316

Q9UBU6
LLICLFLGANAVWYG

PKD1

3286

P98161
TLCLESQGLGGYEWC

SLC35G5

146

Q96KT7
AAGLGFLCLLYSQRW

RMDN3

21

Q96TC7
SQGLSGYDWCGLLGC

SLC35G3

151

Q8N808
GYDWCGLLGCILGLI

SLC35G3

156

Q8N808
AIAALGALILGCWCY

SNN

21

O75324
YLLLLVGCQAWGAGL

LRRC15

6

Q8TF66
LWCIGVLCYELLVGN

AURKB

256

Q96GD4
GCWGLVIYAATGAIC

SLC45A4

561

Q5BKX6
CITVLLGCAGWYGAT

TSPAN16

66

Q9UKR8
CYECEGLLWGIARQG

UNC13C

1111

Q8NB66
SQIFYSLGCAWGGLI

SLC6A9

366

P48067
CYECEGLLWGIARQG

UNC13B

491

O14795
LQCGAWVGQCALYIV

STIMATE

146

Q86TL2
EGCILWANGIYLVCG

TCF20

1856

Q9UGU0
YGAAWIGIFVGICLF

UPK1B

56

O75841
LEWCKCLLAGGGGYD

UBR3

91

Q6ZT12
FNLIFWLCGCGLLGV

TSPAN9

16

O75954
LQLWLPVGCGCFFLG

XKR8

316

Q9H6D3