Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXJ2 TCF7 ATOH1 ZNF319 EMX2 EN1 FOXJ3 ZIC5 NOTCH1 FOXB2	3.38e-05	1271	34	10	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	FOXJ2 TCF7 ATOH1 ZNF319 EMX2 EN1 FOXJ3 ZIC5 NOTCH1 FOXB2	8.25e-05	1412	34	10	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXJ2 TCF7 ATOH1 ZNF319 EMX2 EN1 FOXJ3 ZIC5 FOXB2	1.74e-04	1244	34	9	GO:0000978
GeneOntologyMolecularFunction	molecular adaptor activity	MED15 ATN1 RUNX1T1 NKD2 KMT2E FNTA RBM33 NOTCH1 BRD4	3.32e-04	1356	34	9	GO:0060090
GeneOntologyMolecularFunction	transcription coregulator activity	MED15 ATN1 RUNX1T1 KMT2E NOTCH1 BRD4	3.33e-04	562	34	6	GO:0003712
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	FOXJ2 TCF7 ATOH1 ZNF319 EMX2 EN1 FOXJ3 ZIC5 FOXB2	5.70e-04	1459	34	9	GO:0000977
GeneOntologyMolecularFunction	transcription coactivator activity	ATN1 KMT2E NOTCH1 BRD4	1.68e-03	303	34	4	GO:0003713
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXJ2 ATOH1 ZNF319 FOXJ3 NOTCH1	2.42e-03	560	34	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXJ2 ATOH1 ZNF319 FOXJ3 NOTCH1	2.53e-03	566	34	5	GO:0001216
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD1B KMT2E	2.55e-03	44	34	2	GO:0140938
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	MED15 ATN1 RUNX1T1 KMT2E RBM33 NOTCH1 BRD4	2.96e-03	1160	34	7	GO:0030674
GeneOntologyBiologicalProcess	inner ear receptor cell fate commitment	ATOH1 NOTCH1	3.94e-05	6	34	2	GO:0060120
GeneOntologyBiologicalProcess	auditory receptor cell fate commitment	ATOH1 NOTCH1	3.94e-05	6	34	2	GO:0009912
GeneOntologyBiologicalProcess	regulation of inner ear auditory receptor cell differentiation	ATOH1 NOTCH1	1.72e-04	12	34	2	GO:0045607
GeneOntologyBiologicalProcess	regulation of mechanoreceptor differentiation	ATOH1 NOTCH1	1.72e-04	12	34	2	GO:0045631
GeneOntologyBiologicalProcess	regulation of inner ear receptor cell differentiation	ATOH1 NOTCH1	1.72e-04	12	34	2	GO:2000980
GeneOntologyCellularComponent	chromatin	FOXJ2 TCF7 SFPQ ATOH1 KMT2E EMX2 EN1 FOXJ3 BRD4 FOXB2	1.09e-04	1480	35	10	GO:0000785
Domain	TF_fork_head_CS_2	FOXJ2 FOXJ3 FOXB2	7.93e-05	46	34	3	IPR030456
Domain	TF_fork_head_CS_1	FOXJ2 FOXJ3 FOXB2	8.46e-05	47	34	3	IPR018122
Domain	FORK_HEAD_3	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	PS50039
Domain	FH	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	SM00339
Domain	FORK_HEAD_1	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	PS00657
Domain	FORK_HEAD_2	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	PS00658
Domain	Forkhead	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	PF00250
Domain	Fork_head_dom	FOXJ2 FOXJ3 FOXB2	9.59e-05	49	34	3	IPR001766
Domain	RRM	CPEB3 SFPQ SETD1B RBM33	6.25e-04	217	34	4	SM00360
Domain	RRM_dom	CPEB3 SFPQ SETD1B RBM33	7.40e-04	227	34	4	IPR000504
Domain	RRM	CPEB3 SFPQ SETD1B RBM33	7.77e-04	230	34	4	PS50102
Domain	-	CPEB3 SFPQ SETD1B RBM33	9.69e-04	244	34	4	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	CPEB3 SFPQ SETD1B RBM33	1.19e-03	258	34	4	IPR012677
Domain	SET	SETD1B KMT2E	2.52e-03	41	34	2	PF00856
Domain	SET	SETD1B KMT2E	3.17e-03	46	34	2	SM00317
Domain	SET_dom	SETD1B KMT2E	3.73e-03	50	34	2	IPR001214
Domain	SET	SETD1B KMT2E	3.73e-03	50	34	2	PS50280
Domain	RRM_1	CPEB3 SFPQ SETD1B	6.32e-03	208	34	3	PF00076
Domain	HTH_motif	EMX2 EN1	6.99e-03	69	34	2	IPR000047
Domain	-	FOXJ2 FOXJ3 FOXB2	7.19e-03	218	34	3	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXJ2 FOXJ3 FOXB2	9.56e-03	242	34	3	IPR011991
Domain	EGF_CA	MEGF8 NOTCH1	1.07e-02	86	34	2	PF07645
Domain	Homeobox_metazoa	EMX2 EN1	1.17e-02	90	34	2	IPR020479
Domain	EGF_Ca-bd_CS	MEGF8 NOTCH1	1.34e-02	97	34	2	IPR018097
Domain	EGF_CA	MEGF8 NOTCH1	1.40e-02	99	34	2	PS01187
Domain	ASX_HYDROXYL	MEGF8 NOTCH1	1.42e-02	100	34	2	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	MEGF8 NOTCH1	1.59e-02	106	34	2	IPR000152
Pathway	WP_OVERLAP_BETWEEN_SIGNAL_TRANSDUCTION_PATHWAYS_CONTRIBUTING_TO_LMNA_LAMINOPATHIES	TCF7 FNTA NOTCH1	1.35e-04	57	25	3	M39877
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	FBRSL1 MED15 SFPQ ATN1 FOXJ3 RBM33	9.22e-09	152	35	6	38360978
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FOXJ2 SFPQ CKAP4 ATN1 ZNF319 NKD2 KMT2E PHLDA1 RBM33 BRD4 RNF111	1.58e-08	1203	35	11	29180619
Pubmed	Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip.	ATOH1 EN1 NOTCH1	7.81e-08	9	35	3	17319963
Pubmed	Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.	TCF7 EN1 NOTCH1	3.37e-07	14	35	3	10090727
Pubmed	Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.	ATOH1 BRD4	9.84e-07	2	35	2	31292434
Pubmed	Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.	ATN1 RUNX1T1	9.84e-07	2	35	2	10973986
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXJ2 TCF7 ATOH1 EMX2 EN1 FOXJ3 ZIC5	1.01e-06	544	35	7	28473536
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	TCF7 ATOH1 RUNX1T1 EMX2 EN1	1.35e-06	191	35	5	24146773
Pubmed	Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse.	ATOH1 NOTCH1	2.95e-06	3	35	2	19181188
Pubmed	Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors.	ATOH1 EN1	2.95e-06	3	35	2	16202705
Pubmed	Effects of FOXJ2 on TGF-β1-induced epithelial-mesenchymal transition through Notch signaling pathway in non-small lung cancer.	FOXJ2 NOTCH1	2.95e-06	3	35	2	27611107
Pubmed	Conditional loss of Engrailed1/2 in Atoh1-derived excitatory cerebellar nuclear neurons impairs eupneic respiration in mice.	ATOH1 EN1	2.95e-06	3	35	2	35044072
Pubmed	Notch signaling and Atoh1 expression during hair cell regeneration in the mouse utricle.	ATOH1 NOTCH1	2.95e-06	3	35	2	20433915
Pubmed	T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.	TCF7 NOTCH1	2.95e-06	3	35	2	22109558
Pubmed	Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons.	ATOH1 EN1	2.95e-06	3	35	2	34542409
Pubmed	Multiple roles of mesenchymal beta-catenin during murine limb patterning.	TCF7 EMX2 EN1	3.72e-06	30	35	3	16495310
Pubmed	Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.	ATOH1 NOTCH1	5.90e-06	4	35	2	26999738
Pubmed	Effects of Emx2 inactivation on the gene expression profile of neural precursors.	EMX2 NOTCH1	5.90e-06	4	35	2	16420441
Pubmed	Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice.	ATOH1 NOTCH1	5.90e-06	4	35	2	12208538
Pubmed	Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.	ATOH1 NOTCH1	5.90e-06	4	35	2	19154718
Pubmed	Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern.	ATOH1 EN1	5.90e-06	4	35	2	27609139
Pubmed	A human MAP kinase interactome.	PTPN23 ARHGAP17 SFPQ MAP4K4 RBM33 RNF111	8.31e-06	486	35	6	20936779
Pubmed	Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression.	TCF7 NOTCH1	9.82e-06	5	35	2	11447280
Pubmed	Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells.	EN1 NOTCH1	9.82e-06	5	35	2	23136394
Pubmed	Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification.	ATOH1 NOTCH1	9.82e-06	5	35	2	16736472
Pubmed	Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.	ATOH1 NOTCH1	9.82e-06	5	35	2	22190634
Pubmed	Misexpression of Gbx2 throughout the mesencephalon by a conditional gain-of-function transgene leads to deletion of the midbrain and cerebellum in mice.	ATOH1 EN1	9.82e-06	5	35	2	19603509
Pubmed	Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.	EMX2 EN1	1.47e-05	6	35	2	11782416
Pubmed	Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.	ATOH1 NOTCH1	2.06e-05	7	35	2	19598246
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1B KMT2E	2.74e-05	8	35	2	23130995
Pubmed	Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus.	ATOH1 NOTCH1	2.74e-05	8	35	2	17728348
Pubmed	Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea.	ATOH1 NOTCH1	2.74e-05	8	35	2	19011097
Pubmed	Math1 regulates development of the sensory epithelium in the mammalian cochlea.	ATOH1 NOTCH1	2.74e-05	8	35	2	15543141
Pubmed	FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.	TCF7 ATOH1 EN1	2.77e-05	58	35	3	16782087
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	MED15 SFPQ RBM33 NOTCH1	3.20e-05	180	35	4	35198878
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	SFPQ CKAP4 MAP4K4 RBM33	3.35e-05	182	35	4	32239614
Pubmed	Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.	ATOH1 EN1	3.53e-05	9	35	2	28392070
Pubmed	LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum.	ATOH1 EN1	3.53e-05	9	35	2	17664423
Pubmed	Role of p63 and the Notch pathway in cochlea development and sensorineural deafness.	ATOH1 NOTCH1	4.40e-05	10	35	2	23589895
Pubmed	The isthmic neuroepithelium is essential for cerebellar midline fusion.	ATOH1 EN1	4.40e-05	10	35	2	14507778
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SFPQ ATN1 FOXJ3 RBM33	4.56e-05	197	35	4	20811636
Pubmed	The homeobox containing gene Lbx1 is required for correct dorsal-ventral patterning of the neural tube.	ATOH1 EN1	5.38e-05	11	35	2	12358782
Pubmed	Sufu- and Spop-mediated regulation of Gli2 is essential for the control of mammalian cochlear hair cell differentiation.	ATOH1 EMX2	5.38e-05	11	35	2	36252002
Pubmed	Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice.	ATOH1 EN1	5.38e-05	11	35	2	29972353
Pubmed	Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum.	ATOH1 NOTCH1	5.38e-05	11	35	2	34107249
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	MED15 ARHGAP17 CKAP4 ATN1 RBM33	6.39e-05	425	35	5	24999758
Pubmed	Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.	ATOH1 NOTCH1	6.45e-05	12	35	2	25535395
Pubmed	Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.	EMX2 EN1	6.45e-05	12	35	2	9486536
Pubmed	Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK).	EN1 MAP4K4	6.45e-05	12	35	2	11290295
Pubmed	Ectopic engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding.	ATOH1 EN1	6.45e-05	12	35	2	10952903
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXJ2 TCF7 EMX2 FOXJ3 BRD4 RNF111	6.89e-05	709	35	6	22988430
Pubmed	Genetic control of brain morphogenesis through Otx gene dosage requirement.	EMX2 EN1	7.62e-05	13	35	2	9342056
Pubmed	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.	SFPQ EN1	7.62e-05	13	35	2	19144721
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PTPN23 SFPQ CKAP4 ATN1 PHLDA1 MAP4K4 RBM33 BRD4	7.74e-05	1451	35	8	30550785
Pubmed	bHLH gene expression in the Emx2-deficient dentate gyrus reveals defective granule cells and absence of migrating precursors.	EMX2 NOTCH1	8.89e-05	14	35	2	15084498
Pubmed	Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.	EN1 NOTCH1	8.89e-05	14	35	2	17359917
Pubmed	Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.	ATOH1 NOTCH1	8.89e-05	14	35	2	14757642
Pubmed	Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.	TCF7 EN1	8.89e-05	14	35	2	33195246
Pubmed	Notch1 is required for neuronal and glial differentiation in the cerebellum.	ATOH1 NOTCH1	8.89e-05	14	35	2	11807030
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FBRSL1 ARHGAP17 SETD1B MEGF8 BTBD7 NOTCH1 BRD4	9.89e-05	1105	35	7	35748872
Pubmed	A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development.	ATOH1 EN1	1.02e-04	15	35	2	27414798
Pubmed	Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.	ATOH1 NOTCH1	1.02e-04	15	35	2	27966429
Pubmed	The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.	TCF7 NOTCH1	1.02e-04	15	35	2	26522984
Pubmed	Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.	EN1 NOTCH1	1.02e-04	15	35	2	12167404
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	FOXJ2 ATOH1 FOXJ3 NOTCH1	1.16e-04	251	35	4	29031500
Pubmed	Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population.	EMX2 EN1	1.17e-04	16	35	2	12015293
Pubmed	Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.	ATOH1 NOTCH1	1.17e-04	16	35	2	16061358
Pubmed	Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.	ATOH1 EMX2	1.17e-04	16	35	2	21300049
Pubmed	Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.	ATOH1 NOTCH1	1.17e-04	16	35	2	11739954
Pubmed	Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain.	EMX2 EN1	1.17e-04	16	35	2	21925158
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	EMX2 EN1	1.17e-04	16	35	2	19527706
Pubmed	Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.	FOXJ2 FOXB2	1.17e-04	16	35	2	16376864
Pubmed	Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.	ATOH1 EN1	1.17e-04	16	35	2	16728479
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	MED15 TCF7 SETD1B BRD4	1.27e-04	257	35	4	30945288
Pubmed	SMAD4 is essential for generating subtypes of neurons during cerebellar development.	ATOH1 EN1	1.33e-04	17	35	2	22370000
Pubmed	Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region.	ATOH1 EN1	1.33e-04	17	35	2	16571630
Pubmed	A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.	EMX2 EN1	1.33e-04	17	35	2	12361972
Pubmed	Increased β-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics.	EMX2 EN1	1.33e-04	17	35	2	22102609
Pubmed	FGFR1 is required for the development of the auditory sensory epithelium.	ATOH1 NOTCH1	1.33e-04	17	35	2	12194867
Pubmed	A threshold requirement for Gbx2 levels in hindbrain development.	ATOH1 EN1	1.33e-04	17	35	2	16651541
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	FOXJ2 TCF7 FOXJ3 ZIC5 BTBD7 BRD4	1.41e-04	808	35	6	20412781
Pubmed	The graded response to Sonic Hedgehog depends on cilia architecture.	ATOH1 EN1	1.49e-04	18	35	2	17488627
Pubmed	Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2.	EN1 PHLDA1	1.49e-04	18	35	2	24066094
Pubmed	Notch signaling is a critical initiator of roof plate formation as revealed by the use of RNA profiling of the dorsal neural tube.	ATOH1 NOTCH1	1.49e-04	18	35	2	33892704
Pubmed	Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.	ATOH1 EN1	1.49e-04	18	35	2	17166916
Pubmed	Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development.	ATOH1 EN1	1.49e-04	18	35	2	23459943
Pubmed	Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.	ATN1 EMX2	1.49e-04	18	35	2	14645126
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED15 ATN1 RBM33 BRD4	1.50e-04	268	35	4	33640491
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	EMX2 EN1	1.66e-04	19	35	2	9895322
Pubmed	Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors.	TCF7 NOTCH1	1.66e-04	19	35	2	16292344
Pubmed	CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse.	EMX2 EN1	1.85e-04	20	35	2	17067568
Pubmed	Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.	ATOH1 NOTCH1	1.85e-04	20	35	2	19542352
Pubmed	FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation.	ATOH1 EMX2	1.85e-04	20	35	2	24465223
Pubmed	beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region.	TCF7 EN1	1.85e-04	20	35	2	20532162
Pubmed	Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea.	ATOH1 EMX2	1.85e-04	20	35	2	23946445
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGAP17 NKD2 MEGF8 MAP4K4 DENND2B BRD4	1.99e-04	861	35	6	36931259
Pubmed	Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms.	ATOH1 EN1	2.04e-04	21	35	2	17321515
Pubmed	Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.	ATOH1 EN1	2.04e-04	21	35	2	11500373
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	FOXJ2 TCF7 ATOH1 RUNX1T1 NKD2 EMX2	2.20e-04	877	35	6	20211142
Pubmed	Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes.	EMX2 EN1	2.24e-04	22	35	2	17241623
Interaction	EYA4 interactions	FBRSL1 MED15 FOXJ2 SFPQ ATN1 FOXJ3 RBM33	1.39e-07	243	34	7	int:EYA4
Interaction	RNF4 interactions	FOXJ2 SFPQ CKAP4 ATN1 RUNX1T1 ZNF319 NKD2 KMT2E PHLDA1 RBM33 BRD4 RNF111	1.72e-06	1412	34	12	int:RNF4
Interaction	TLE3 interactions	FBRSL1 MED15 FOXJ2 ATN1 EN1 NOTCH1 BRD4	2.59e-06	376	34	7	int:TLE3
Interaction	HCFC1 interactions	MED15 SETD1B ATN1 KMT2E NOTCH1 BRD4	8.57e-06	293	34	6	int:HCFC1
Interaction	SMARCA5 interactions	FOXJ2 SFPQ FOXJ3 MAP4K4 NOTCH1 BRD4	6.07e-05	415	34	6	int:SMARCA5
Interaction	TAF1 interactions	FBRSL1 CKAP4 ATN1 NOTCH1 BRD4	7.05e-05	260	34	5	int:TAF1
GeneFamily	Forkhead boxes	FOXJ2 FOXJ3 FOXB2	2.78e-05	43	25	3	508
GeneFamily	RNA binding motif containing	CPEB3 SFPQ SETD1B RBM33	1.95e-04	213	25	4	725
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B KMT2E	1.00e-03	34	25	2	487
GeneFamily	NKL subclass homeoboxes and pseudogenes	EMX2 EN1	3.84e-03	67	25	2	519
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	PTPN23 SETD1B KMT2E FOXJ3	8.56e-06	166	35	4	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RUNX1T1 NKD2 PHLDA1 DENND2B	1.03e-05	174	35	4	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SFPQ FNTA EN1 MAP4K4	1.13e-05	178	35	4	b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EMX2 EN1	1.28e-05	184	35	4	fea4fe648e9749177d0783443dc26a7df5807883
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EMX2 EN1	1.28e-05	184	35	4	96a8a0a190bc293655fe7d80cbed8119c0da25f2
ToppCell	facs-Skin-Skin_Anagen-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EMX2 EN1	1.28e-05	184	35	4	780eb72da43527f0c72effac3423ec7384f05f20
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ ATN1 PHLDA1 NOTCH1	1.34e-05	186	35	4	bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKAP4 KMT2E PHLDA1 BRD4	1.40e-05	188	35	4	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFPQ ATN1 PHLDA1 NOTCH1	1.43e-05	189	35	4	965e0e388251e7318f8b463816dc96ccb4658677
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP17 RUNX1T1 PHLDA1 DENND2B	1.49e-05	191	35	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP17 RUNX1T1 PHLDA1 DENND2B	1.49e-05	191	35	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	ATN1 MEGF8 PHLDA1 MAP4K4	1.78e-05	200	35	4	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FBRSL1 TCF7 PHLDA1	2.11e-04	148	35	3	a261c6d3d9cf0311c053fca66c37d39e66db6ad8
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	FBRSL1 TCF7 PHLDA1	2.11e-04	148	35	3	c0237ba7d4040b6a497094b362dfb8b3a97a7d06
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	EMX2 PHLDA1 MAP4K4	2.47e-04	156	35	3	7e6805ebc7bc2f9c5965321d16922c155719970f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	EMX2 PHLDA1 MAP4K4	2.47e-04	156	35	3	741de05295b2d012ac8576378f37709a97c8fb50
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh\|GI_large-bowel / Manually curated celltypes from each tissue	TCF7 SETD1B KMT2E	2.81e-04	163	35	3	4104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FOXJ2 TCF7 BTBD7	3.12e-04	169	35	3	01a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RUNX1T1 NKD2 PHLDA1	3.12e-04	169	35	3	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SFPQ FNTA MAP4K4	3.12e-04	169	35	3	50cc0f5a022b95986949db63208a627cef9f4a69
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	3.28e-04	172	35	3	55fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATOH1 CKAP4 PRR36	3.45e-04	175	35	3	019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	3.51e-04	176	35	3	2bc4d3ddc2f752d8255dec0e7a9b87c7f82a372d
ToppCell	5'-Adult-Distal_Rectal-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATOH1 CKAP4 PRR36	3.63e-04	178	35	3	9099b47e0756d6a1b7ba1c6aa7b47c5425f649e0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 NKD2 DENND2B	3.63e-04	178	35	3	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FBRSL1 ARHGAP17 SETD1B	3.75e-04	180	35	3	62511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SFPQ KMT2E MAP4K4	4.06e-04	185	35	3	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.13e-04	186	35	3	41e03be964044dae690d566bd078dab3d8045eba
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.19e-04	187	35	3	401be371b32066db926de3415bb4ce9465749dc3
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.19e-04	187	35	3	5c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.19e-04	187	35	3	5d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-osteoclast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PHLDA1 MAP4K4 DENND2B	4.26e-04	188	35	3	762b52f21d2bc5409f86746a904c4358490be9c0
ToppCell	facs-Skin-nan-18m-Mesenchymal-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EN1	4.33e-04	189	35	3	29287525120be2953b76881ba3cfc4379c265e7a
ToppCell	facs-Skin-nan-18m-Mesenchymal-fibroblast\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EN1	4.33e-04	189	35	3	7150dad9a92a715487c2d8130fa01b752ea69663
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF7 RUNX1T1 PHLDA1	4.33e-04	189	35	3	3169476f98b7385706cb618c9ad64ae83a290ef0
ToppCell	facs-Skin-nan-18m-Mesenchymal\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RUNX1T1 NKD2 EN1	4.33e-04	189	35	3	6e4c0effd5192fd00052abc048fdb87a74fb6554
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SFPQ KMT2E MAP4K4	4.39e-04	190	35	3	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EMX2 PHLDA1 MUC7	4.39e-04	190	35	3	70b14b649ae893513e6d61b7288d6f6df97f09d9
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 NKD2 DENND2B	4.39e-04	190	35	3	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.39e-04	190	35	3	5c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.39e-04	190	35	3	3a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 NKD2 DENND2B	4.39e-04	190	35	3	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.39e-04	190	35	3	1c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	RUNX1T1 NKD2 EMX2	4.46e-04	191	35	3	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	15-Trachea-Epithelial-Submucosal_gland_basal\|Trachea / Age, Tissue, Lineage and Cell class	CKAP4 NKD2 PHLDA1	4.46e-04	191	35	3	409e12d2bb26b6d2ed025304ca6ace07df16638a
ToppCell	5'-Adult-LymphNode-Mesenchymal\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NKD2 EN1 PHLDA1	4.46e-04	191	35	3	054e9a79bd1486fd812bc7418fb091664fe3a646
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NKD2 EN1 PHLDA1	4.53e-04	192	35	3	9479e9859140ba98abfe88414de0b28fc2bf43b7
ToppCell	5'-Adult-LymphNode-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NKD2 EN1 PHLDA1	4.53e-04	192	35	3	d7faa993f68e530ad55185505384ae155d36c222
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.53e-04	192	35	3	f7e4509003d71f805b9d4587098e90d2897b6739
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.53e-04	192	35	3	705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RUNX1T1 EMX2 EN1	4.60e-04	193	35	3	09de51f8ac509e03d480ed3dc9dfe7e7defc59cb
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.60e-04	193	35	3	b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	KMT2E MAP4K4 RBM33	4.60e-04	193	35	3	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EMX2 ZIC5 NOTCH1	4.60e-04	193	35	3	40edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 SFPQ MAP4K4	4.67e-04	194	35	3	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 SFPQ MAP4K4	4.67e-04	194	35	3	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 SFPQ MAP4K4	4.67e-04	194	35	3	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	normal_Lung-T/NK_cells-CD4+_Th\|normal_Lung / Location, Cell class and cell subclass	TCF7 KMT2E PHLDA1	4.74e-04	195	35	3	d6c69f149f3d96fe83f920e38277dede102d04b5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 NKD2 DENND2B	4.74e-04	195	35	3	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 NKD2 DENND2B	4.74e-04	195	35	3	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TCF7 SFPQ PHLDA1	4.81e-04	196	35	3	74093f85e095606d1c723e0d7c2d78d9cfa47c4f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NKD2 EN1 PHLDA1	4.81e-04	196	35	3	46d665de09f8164690b9a3e0acf0b0afa3f81b3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 PHLDA1 DENND2B	4.88e-04	197	35	3	09946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	EMX2 PHLDA1 MAP4K4	4.95e-04	198	35	3	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	15-Airway-Mesenchymal-Mesenchyme_SERPINF1-high\|Airway / Age, Tissue, Lineage and Cell class	CKAP4 RUNX1T1 NKD2	4.95e-04	198	35	3	3d76393e72eed59b4dd16130ef5dd1d331ba5711
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RUNX1T1 PHLDA1 DENND2B	4.95e-04	198	35	3	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_A\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	SFPQ KMT2E PHLDA1	4.95e-04	198	35	3	a1c8e5c332336823c47c04e56b6d7bc8f057c9da
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	EMX2 PHLDA1 MAP4K4	4.95e-04	198	35	3	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	RUNX1T1 KMT2E MAP4K4	4.95e-04	198	35	3	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-early\|World / Primary Cells by Cluster	EMX2 PHLDA1 NOTCH1	5.03e-04	199	35	3	549391e7a4285da1c0e366654530bcf1cd33fbae
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-early-40\|World / Primary Cells by Cluster	EMX2 PHLDA1 NOTCH1	5.03e-04	199	35	3	23625d757173bdd35a51c7919ff4b588168d2553
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RUNX1T1 PHLDA1 DENND2B	5.03e-04	199	35	3	a272c54baf8de59c0f259e6498d144a0de8d8924
ToppCell	distal-1-mesenchymal-Lipofibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NKD2 EN1 PHLDA1	5.03e-04	199	35	3	a8293db3c42a8d30897858b49aae7acfc18663ba
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ATN1 MAP4K4 DENND2B	5.03e-04	199	35	3	fcbb3a9c0f4c5b4c1f09db24b9f50cc1166fa43b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	PCARE PHLDA1 NOTCH1	5.10e-04	200	35	3	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	Tracheal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP17 RUNX1T1 EMX2	5.10e-04	200	35	3	9d3ae9ea47b1017adb63aa02d10e98193d478458
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	PCARE PHLDA1 NOTCH1	5.10e-04	200	35	3	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Macroglial\|3m / Sample Type, Dataset, Time_group, and Cell type.	EMX2 PHLDA1 NOTCH1	5.10e-04	200	35	3	38b51f337e183011e3ff32997ec26d8a424c6b78
ToppCell	MS-IIF-Lymphocyte-T/NK-CD8+_Tcm\|IIF / Disease, condition lineage and cell class	C20orf203 TCF7 KMT2E	5.10e-04	200	35	3	01554c0b7b8d7a12d99853fe057a20ed775ee5b2
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SFPQ KMT2E RBM33	5.10e-04	200	35	3	12f1685ce8f218433068e090c9d839cd5a1910bf
Drug	6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	PTPN23 ATN1 PRR36 NOTCH1 BRD4	5.25e-07	104	35	5	ctd:C000595015
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A	CPEB3 SFPQ RUNX1T1 PHLDA1 FOXJ3	4.97e-06	164	35	5	3852_UP
Drug	Famprofazone [22881-35-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CPEB3 SETD1B ATN1 MEGF8 PHLDA1	1.15e-05	195	35	5	3834_UP
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	MED15 TCF7 ATN1 PHLDA1 BRD4	1.24e-05	198	35	5	2316_DN
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	MED15 ATN1 PRR36 FOXJ3 BTBD7	1.27e-05	199	35	5	7338_DN
Disease	triglyceride measurement, coronary artery disease	FBRSL1 SETD1B	8.19e-06	4	35	2	EFO_0001645, EFO_0004530
Disease	diastolic blood pressure, systolic blood pressure	KMT2E RBM33 ZIC5 DENND2B BRD4	1.10e-03	670	35	5	EFO_0006335, EFO_0006336
Disease	aortic stenosis, aortic valve calcification	FBRSL1 EMX2	1.14e-03	42	35	2	EFO_0000266, EFO_0005239
Disease	Adult Medulloblastoma	ATOH1 BRD4	1.20e-03	43	35	2	C0278876
Disease	Childhood Medulloblastoma	ATOH1 BRD4	1.20e-03	43	35	2	C0278510
Disease	Melanotic medulloblastoma	ATOH1 BRD4	1.20e-03	43	35	2	C1275668
Disease	Medullomyoblastoma	ATOH1 BRD4	1.20e-03	43	35	2	C0205833
Disease	Desmoplastic Medulloblastoma	ATOH1 BRD4	1.20e-03	43	35	2	C0751291
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	FBRSL1 SETD1B	1.55e-03	49	35	2	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	Medulloblastoma	ATOH1 BRD4	1.62e-03	50	35	2	C0025149
Disease	nervous system disorder	EN1 NOTCH1	1.81e-03	53	35	2	C0027765
Disease	Intellectual Disability	PTPN23 ATN1 KMT2E BRD4	1.88e-03	447	35	4	C3714756
Disease	basophil measurement	C20orf203 CKAP4	2.32e-03	60	35	2	EFO_0803539
Disease	opioid dependence	ARHGAP17 ATOH1 RNF111	2.77e-03	237	35	3	EFO_0005611
Disease	schizophrenia (is_implicated_in)	MED15 ATN1	3.88e-03	78	35	2	DOID:5419 (is_implicated_in)
Disease	Glioblastoma	NOTCH1 BRD4	3.98e-03	79	35	2	C0017636
Disease	Giant Cell Glioblastoma	NOTCH1 BRD4	4.48e-03	84	35	2	C0334588
Disease	lung adenocarcinoma (is_marker_for)	EMX2 MAP4K4	4.59e-03	85	35	2	DOID:3910 (is_marker_for)
Disease	obsolete_red blood cell distribution width	FBRSL1 SETD1B NKD2 DENND2B NOTCH1 BRD4	4.66e-03	1347	35	6	EFO_0005192
Disease	Alzheimer disease, APOE carrier status	ZIC5 NOTCH1	6.05e-03	98	35	2	EFO_0007659, MONDO_0004975
Disease	Adenoid Cystic Carcinoma	EN1 NOTCH1	6.29e-03	100	35	2	C0010606
Disease	Glioblastoma Multiforme	NOTCH1 BRD4	7.70e-03	111	35	2	C1621958
Disease	interleukin-6 measurement	KMT2E BTBD7	7.83e-03	112	35	2	EFO_0004810

Protein segments in the cluster

Peptide	Gene	Start	Entry
PPAPHRHTPQPPPPQ	FBRSL1	291	Q9HCM7
QQPPPPPAPHPQQHP	CKAP4	41	Q07065
PPAPHPQQHPQQHPQ	CKAP4	46	Q07065
PQPELPPHLPQPPEH	BRD4	831	O60885
PANFPHVTPNLPPPP	ATN1	291	P54259
HPPAPSPQNPQDPSP	DENND2B	71	P78524
PNLQGPLHPPLPPPH	RBM33	576	Q96EV2
PPPQHQPPHQPPHQP	RBM33	601	Q96EV2
QPPHQPPHQPPPQHQ	RBM33	606	Q96EV2
PPHQPPPQHQPPPQH	RBM33	611	Q96EV2
PPQHQPPPQHPPQHP	RBM33	616	Q96EV2
PPPQHPPQHPPQHQH	RBM33	621	Q96EV2
IGPQPQPHPQPHPSQ	PTPN23	951	Q9H3S7
PHPQHSQQPPPPQQE	MAP4K4	531	O95819
HQQPPTAPQPPPHLP	FOXB2	181	Q5VYV0
TAPQPPPHLPSQPPQ	FOXB2	186	Q5VYV0
QSLQPPPPPPQPHLG	NOTCH1	2406	P46531
PNGLPHPTPPPPQHY	RUNX1T1	286	Q06455
PQPSHQRQPPPPQHP	C20orf203	76	Q8NBC4
TQHHQPPPQPQQPPV	MED15	296	Q96RN5
VHTVHIQPPPAPPPP	MEGF8	2521	Q7Z7M0
QHQHVVNSAPPPPPP	KMT2E	1706	Q8IZD2
HPHSHPAQQPPPPQP	FOXJ2	381	Q9P0K8
PPPQHLAAPAHQPQP	EN1	81	Q05925
PQDGHHLPQPPPPPY	NKD2	366	Q969F2
PSPNNPPKFPNPHQP	MUC7	76	Q8TAX7
QHHQQPPPPAPAPQP	CPEB3	161	Q8NE35
PQHPQRSPHPAPHPQ	FOXJ3	391	Q9UPW0
HHLPQPPPPPQPPAT	ATOH1	26	Q92858
PPPPYHPPATPIHNQ	BTBD7	761	Q9P203
SHPPNPAVPVHPVPP	EMX2	76	Q04743
PHQPKLPNPPPESAP	PCARE	1051	A6NGG8
SPIQAPNHPPPQPPT	ARHGAP17	706	Q68EM7
PNHPPPQPPTQATPL	ARHGAP17	711	Q68EM7
QPPPQPHPPPPQQQH	FNTA	21	P49354
SPPLQAPPHPQAPPS	PRR36	556	Q9H6K5
PPHHHHQQPPPQPGP	SETD1B	6	Q9UPS6
QPPPHQPPPHPQPHQ	SFPQ	81	P23246
QPPPHPQPHQQQQPP	SFPQ	86	P23246
HSHGNPPPQTQPPPQ	RNF111	666	Q6ZNA4
PKPQPQQLHPYPHPH	PHLDA1	341	Q8WV24
PQPQPPLHKANQPPH	TCF7	141	P36402
PQPPQPQHHAEPPPA	ZNF319	16	Q9P2F9
PPPPAPAQHPHQHHP	ZIC5	361	Q96T25