Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	postsynaptic density, intracellular component	GRID2IP IQSEC2 DLG3 NOS1	1.03e-05	49	58	4	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	GRID2IP IQSEC2 DLG3 NOS1	1.76e-05	56	58	4	GO:0099091
GeneOntologyCellularComponent	aggresome	PSAP BAG3 CABIN1	1.86e-04	40	58	3	GO:0016235
HumanPheno	Abnormal midface morphology	SETD1A SH3PXD2B GTF2I ATRX PCLO IQSEC2 DLG3 RRAS CDC6 RREB1 RAI1	5.37e-05	704	22	11	HP:0000309
HumanPheno	Abnormality of the knee	CCDC88C SH3PXD2B GTF2I PSAP ATRX BAG3 SMG9 CDC6 RREB1	1.05e-04	491	22	9	HP:0002815
HumanPheno	Short REM sleep	IQSEC2 RAI1	1.06e-04	4	22	2	HP:5200360
HumanPheno	Abnormal sleep architecture	IQSEC2 RAI1	1.06e-04	4	22	2	HP:5200298
HumanPheno	Onychotillomania	IQSEC2 RAI1	1.06e-04	4	22	2	HP:0032509
HumanPheno	Vocal cord polyp	IQSEC2 RAI1	1.06e-04	4	22	2	HP:0032041
HumanPheno	Tactile sensory seeking	GUCY2D IQSEC2 RAI1	1.51e-04	25	22	3	HP:5200065
HumanPheno	Gastroesophageal reflux	GTF2I PSAP ATRX IQSEC2 SMG9 CDC6 RREB1 NOS1 RAI1	1.58e-04	517	22	9	HP:0002020
HumanPheno	Typified by age-related disease onset	GUCY2D RP1L1	1.77e-04	5	22	2	HP:0003831
HumanPheno	Polyembolokoilamania	IQSEC2 RAI1	1.77e-04	5	22	2	HP:0032508
HumanPheno	Sensory seeking	GUCY2D IQSEC2 RAI1	2.14e-04	28	22	3	HP:4000079
HumanPheno	Hyperacusis	GTF2I IQSEC2 RAI1	2.14e-04	28	22	3	HP:0010780
HumanPheno	Abnormal interest	GUCY2D IQSEC2 RAI1	2.38e-04	29	22	3	HP:4000068
HumanPheno	Abnormality of the joints of the lower limbs	CCDC88C SH3PXD2B GTF2I PSAP ATRX BAG3 SMG9 CDC6 RREB1	2.44e-04	547	22	9	HP:0100239
HumanPheno	Sensory hypersensitivity	GTF2I PSAP GUCY2D IQSEC2 RP1L1 CNGB3 RAI1	2.66e-04	319	22	7	HP:5200058
HumanPheno	Nail-biting	IQSEC2 RAI1	3.69e-04	7	22	2	HP:0012170
HumanPheno	Sensory behavioral abnormality	GTF2I PSAP GUCY2D IQSEC2 RP1L1 CNGB3 RAI1	3.73e-04	337	22	7	HP:5200046
HumanPheno	Abnormal pineal melatonin secretion	IQSEC2 RAI1	4.91e-04	8	22	2	HP:0012689
HumanPheno	Abnormality of pineal physiology	IQSEC2 RAI1	4.91e-04	8	22	2	HP:0012688
HumanPheno	Auditory sensitivity	GTF2I IQSEC2 RAI1	4.94e-04	37	22	3	HP:0025112
HumanPheno	Auditory hypersensitivity	GTF2I IQSEC2 RAI1	4.94e-04	37	22	3	HP:5200060
HumanPheno	Tip-toe gait	PSAP IQSEC2 BAG3 RAI1	5.45e-04	91	22	4	HP:0030051
MousePheno	abnormal synaptic depression	PTPN4 TRPV1 GRID2IP PCLO SYN1 NOS1	1.28e-06	107	46	6	MP:0002915
MousePheno	abnormal CNS synaptic transmission	DHX15 SETD1A PTPN4 TRPV1 GRID2IP PSAP ATRX PCLO IQSEC2 STAU2 SYN1 DLG3 NOS1	1.11e-05	985	46	13	MP:0002206
MousePheno	abnormal synaptic transmission	DHX15 SETD1A PTPN4 TRPV1 GRID2IP PSAP ATRX PCLO IQSEC2 STAU2 SYN1 DLG3 NOS1	2.70e-05	1070	46	13	MP:0003635
MousePheno	abnormal synaptic physiology	DHX15 SETD1A PTPN4 TRPV1 GRID2IP PSAP ATRX PCLO IQSEC2 STAU2 SYN1 DLG3 NOS1	2.86e-05	1076	46	13	MP:0021009
MousePheno	abnormal neurotransmitter secretion	SETD1A PCLO SYN1 NOS1	6.76e-05	67	46	4	MP:0005445
MousePheno	abnormal learning/memory/conditioning	SEMA3F PTPN4 TRPV1 MFNG GTF2I PSAP ATRX IQSEC2 STAU2 SYN1 DLG3 NOS1 RAI1	1.24e-04	1239	46	13	MP:0002063
MousePheno	abnormal cognition	SEMA3F PTPN4 TRPV1 MFNG GTF2I PSAP ATRX IQSEC2 STAU2 SYN1 DLG3 NOS1 RAI1	1.31e-04	1246	46	13	MP:0014114
MousePheno	abnormal liquid preference	SETD1A TRPV1 NOS1	1.41e-04	31	46	3	MP:0001423
MousePheno	abnormal long-term depression	PTPN4 TRPV1 GRID2IP NOS1	1.49e-04	82	46	4	MP:0001898
MousePheno	abnormal CNS synapse formation	IQSEC2 STAU2 SYN1	2.03e-04	35	46	3	MP:0004996
MousePheno	increased eye anterior chamber depth	TDRD7 SH3PXD2B	2.20e-04	7	46	2	MP:0031213
MousePheno	neuron degeneration	SH3PXD2B PSAP GUCY2D RP1L1 CNGB3 AFF1 RREB1	2.65e-04	391	46	7	MP:0003224
MousePheno	abnormal coronary flow rate	TRPV1 NOS1	2.93e-04	8	46	2	MP:0003021
Domain	PDZ	PTPN4 IL16 GRID2IP MAST4 PCLO DLG3 NOS1	2.88e-07	151	55	7	PS50106
Domain	PDZ	PTPN4 IL16 GRID2IP MAST4 PCLO DLG3 NOS1	3.01e-07	152	55	7	IPR001478
Domain	HMGI/Y_DNA-bd_CS	PRB1 PRB3 PRB4 PRB2	2.00e-06	31	55	4	IPR000637
Domain	PDZ	PTPN4 IL16 GRID2IP MAST4 DLG3 NOS1	3.56e-06	141	55	6	PF00595
Domain	PDZ	PTPN4 IL16 GRID2IP MAST4 DLG3 NOS1	4.71e-06	148	55	6	SM00228
Domain	-	PTPN4 IL16 GRID2IP MAST4 DLG3 NOS1	5.09e-06	150	55	6	2.30.42.10
Pubmed	The involvement of proline-rich protein Mus musculus predicted gene 4736 in ocular surface functions.	PRB1 PRB3 PRB4 PRB2	6.96e-12	4	58	4	27588265
Pubmed	Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over.	PRB1 PRB3 PRB4 PRB2	6.96e-12	4	58	4	2851479
Pubmed	Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system.	PRB1 PRB3 PRB4 PRB2	1.04e-10	6	58	4	2993301
Pubmed	Molecular genetics of human salivary proteins and their polymorphisms.	PRB1 PRB3 PRB4	4.40e-09	3	58	3	3055850
Pubmed	The structure and evolution of the human salivary proline-rich protein gene family.	PRB1 PRB4 PRB2	4.40e-09	3	58	3	8422499
Pubmed	cDNA clones for mouse parotid proline-rich proteins. mRNA regulation by isoprenaline and the nucleotide sequence of proline-rich protein cDNA MP5.	PRB1 PRB3 PRB4	1.76e-08	4	58	3	1339347
Pubmed	The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species.	PRB3 PRB4 PRB2	4.39e-08	5	58	3	26375204
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	UTP18 GTF2I ATRX STAU2 RREB1 CABIN1 RAI1	1.87e-06	349	58	7	25665578
Pubmed	Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy.	TRPV1 NOS1	2.73e-06	2	58	2	23202294
Pubmed	Salivary proline-rich proteins.	PRB1 PRB4	2.73e-06	2	58	2	6810092
Pubmed	PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.	PRB4 PRB2	2.73e-06	2	58	2	8554050
Pubmed	Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases.	PRB3 PRB4	2.73e-06	2	58	2	18463091
Pubmed	Enhanced glycosylation and sulfation of secretory proteoglycans is coupled to the expression of a basic secretory protein.	PRB1 PRB4	2.73e-06	2	58	2	9487127
Pubmed	Fractionation and characterization of basic proline-rich peptides of human parotid saliva and the amino acid sequence of proline-rich peptide P-E.	PRB1 PRB2	2.73e-06	2	58	2	7118863
Pubmed	Basic proline-rich proteins from human parotid saliva: complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair.	PRB1 PRB2	2.73e-06	2	58	2	6924859
Pubmed	Clones from the human gene complex coding for salivary proline-rich proteins.	PRB1 PRB2	2.73e-06	2	58	2	6089212
Pubmed	NANOS2 promotes male germ cell development independent of meiosis suppression.	PRB3 PRB4 PRB2	3.53e-06	18	58	3	24183939
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCDC88C FKBP15 SH3PXD2B ZC3H4 IQSEC2 SYN1 DLG3 CABIN1 NOS1 RAI1	3.96e-06	963	58	10	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	UTP18 GTF2I ATRX RAPH1 ZC3H4 BAG3 AFF1 ZC3H18 RREB1	5.14e-06	774	58	9	15302935
Pubmed	A novel form of capsaicin-modified amygdala LTD mediated by TRPM1.	TRPV1 NOS1	8.19e-06	3	58	2	27633915
Pubmed	Prenatal development of transient receptor potential vanilloid 1-expressing primary sensory projections to sacral autonomic preganglionic neurons.	TRPV1 NOS1	8.19e-06	3	58	2	16973277
Pubmed	Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases.	PRB1 PRB4	8.19e-06	3	58	2	11422372
Pubmed	Finding new posttranslational modifications in salivary proline-rich proteins.	PRB3 PRB4	1.64e-05	4	58	2	20879038
Pubmed	Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants.	IQSEC2 RAI1	1.64e-05	4	58	2	28213671
Pubmed	Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration.	GUCY2D CNGB3	1.64e-05	4	58	2	24550448
Pubmed	Genetic testing for retinal dystrophies and dysfunctions: benefits, dilemmas and solutions.	GUCY2D CNGB3	1.64e-05	4	58	2	17651254
Pubmed	Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual.	PRB4 PRB2	1.64e-05	4	58	2	1849422
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FKBP15 GTF2I CALD1 ATRX RAPH1 ZC3H4 NACA STAU2 BAG3	2.29e-05	934	58	9	33916271
Pubmed	Interaction network of human early embryonic transcription factors.	SETD1A TNRC18 PSAP PYGO2 RREB1 RAI1	2.63e-05	351	58	6	38297188
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	DHX15 GTF2I CALD1 ATRX ZC3H4 STAU2 ZC3H18 RREB1 RAI1	2.70e-05	954	58	9	36373674
Pubmed	Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.	SYN1 NOS1	2.72e-05	5	58	2	11867766
Pubmed	Mutation frequencies of X-linked mental retardation genes in families from the EuroMRX consortium.	ATRX IQSEC2	2.72e-05	5	58	2	17221867
Pubmed	Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction.	PCLO SYN1	4.08e-05	6	58	2	31804576
Pubmed	Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons.	TRPV1 NOS1	4.08e-05	6	58	2	20951772
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DHX15 C14orf93 UTP18 GTF2I ATRX ZC3H18 CDC6 RREB1 CABIN1 RAI1	5.04e-05	1294	58	10	30804502
Pubmed	Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses.	SEMA3F NOS1	5.71e-05	7	58	2	28731029
Pubmed	Spatiotemporal mapping of sensory and motor innervation of the embryonic and postnatal mouse urinary bladder.	TRPV1 NOS1	1.22e-04	10	58	2	33744254
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	MFNG TNRC18 PHACTR2 UTP18 CALD1 ATRX RAPH1 PCLO DLG3 RAI1	1.24e-04	1442	58	10	35575683
Pubmed	DGKι regulates presynaptic release during mGluR-dependent LTD.	SYN1 DLG3	1.49e-04	11	58	2	21119615
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	UTP18 GTF2I PYGO2 ZC3H4 STAU2 BAG3	1.90e-04	503	58	6	16964243
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX15 PHACTR2 GTF2I CALD1 RAPH1 ZC3H4	1.96e-04	506	58	6	30890647
Pubmed	Nomenclature guidelines for X-linked mental retardation.	ATRX IQSEC2	2.11e-04	13	58	2	1605216
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	PCLO SYN1	2.46e-04	14	58	2	21228161
Pubmed	O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.	PCLO SYN1	2.46e-04	14	58	2	16452088
Pubmed	RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.	UTP18 NACA ZC3H18 TRAF3IP3	2.52e-04	183	58	4	28186131
Pubmed	Generation and characterization of Tmeff2 mutant mice.	TRPV1 NOS1	2.83e-04	15	58	2	22828515
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SETD1A SH3PXD2B GTF2I CALD1 RAPH1 BAG3	3.04e-04	549	58	6	38280479
Pubmed	Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.	UTP18 CALD1	3.23e-04	16	58	2	20833366
Pubmed	Mutations in the RNA granule component TDRD7 cause cataract and glaucoma.	TDRD7 STAU2	3.23e-04	16	58	2	21436445
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	IQSEC2 NACA DLG3 NOS1	3.34e-04	197	58	4	36604605
Pubmed	Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function.	CALD1 NACA	3.66e-04	17	58	2	32376900
Pubmed	Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.	SETD1A GTF2I	3.66e-04	17	58	2	21653943
Pubmed	Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.	HOXA4 SYN1	3.66e-04	17	58	2	14736746
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	DHX15 SH3PXD2B UTP18 PSAP CALD1 NACA STAU2 BAG3 ZC3H18	4.09e-04	1367	58	9	32687490
Pubmed	Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.	UTP18 PSAP	4.11e-04	18	58	2	35411049
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	CALD1 RAPH1 NACA BAG3	4.72e-04	216	58	4	31519766
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SETD1A GTF2I ATRX ZC3H18 RAI1	5.09e-04	394	58	5	27248496
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	GTF2I ATRX ZC3H18 RREB1 CABIN1 RAI1	5.21e-04	608	58	6	36089195
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCDC88C SH3PXD2B PHACTR2 MAST4 RAPH1 IQSEC2 BAG3	5.58e-04	861	58	7	36931259
Pubmed	Human transcription factor protein interaction networks.	SETD1A GTF2I PYGO2 ATRX NACA STAU2 ZC3H18 RREB1 CABIN1	5.64e-04	1429	58	9	35140242
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	FKBP15 TNRC18 PCLO IQSEC2 NACA STAU2 DLG3 NOS1	5.79e-04	1139	58	8	36417873
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	DHX15 GTF2I PSAP CALD1 ZC3H4 NACA STAU2 BAG3	6.13e-04	1149	58	8	35446349
Pubmed	TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.	DHX15 GTF2I	6.18e-04	22	58	2	17803295
Pubmed	Smooth muscle contraction and relaxation.	CALD1 LMOD1	6.18e-04	22	58	2	14627618
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	GUCY2D NOS1	6.76e-04	23	58	2	17954614
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETD1A MAST4 CABIN1	7.11e-04	104	58	3	9205841
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	IL16 GTF2I PCLO NACA BAG3	7.16e-04	425	58	5	24999758
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	CCDC88C UTP18 GTF2I STAU2	7.56e-04	245	58	4	35652658
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DHX15 TNRC18 ZC3H4 STAU2 BAG3 ZC3H18	7.69e-04	655	58	6	35819319
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	SYN1 DLG3	8.00e-04	25	58	2	27480238
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	C14orf93 TNRC18 PHACTR2 PYGO2 CALD1 ZC3H4 DLG3 ZC3H18	8.82e-04	1215	58	8	15146197
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TNRC18 PYGO2 ZC3H4 RAI1	1.06e-03	268	58	4	33640491
Pubmed	Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.	DHX15 STAU2	1.08e-03	29	58	2	21266579
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	GTF2I CABIN1	1.23e-03	31	58	2	23602572
Pubmed	The synaptic vesicle cycle.	PCLO SYN1	1.23e-03	31	58	2	15217342
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	DHX15 SH3PXD2B CALD1 ZC3H4 STAU2 SMG9	1.29e-03	724	58	6	36232890
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	GTF2I ATRX ZC3H4 ZC3H18	1.29e-03	283	58	4	30585729
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	DHX15 SH3PXD2B UTP18 ZC3H4 NACA	1.30e-03	486	58	5	30940648
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	DHX15 UTP18 GTF2I ZC3H4 NACA ZC3H18	1.35e-03	731	58	6	29298432
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	DHX15 FKBP15 GTF2I	1.39e-03	131	58	3	34551306
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SH3PXD2B CALD1 RAPH1 PCLO SYN1	1.45e-03	498	58	5	36634849
Pubmed	Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.	DHX15 GTF2I ZC3H4	1.54e-03	136	58	3	26979993
Pubmed	Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.	PTPN4 DLG3	1.66e-03	36	58	2	26053890
Interaction	EPB41L3 interactions	DHX15 SETD1A TRPV1 TNRC18 ATRX AFF1 ZC3H18	9.96e-06	272	56	7	int:EPB41L3
Cytoband	12p13.2	PRB1 PRB3 PRB4 PRB2	3.29e-07	45	58	4	12p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	PRB1 PRB3 PRB4 PRB2	1.05e-03	353	58	4	chr12p13
Cytoband	7p22.1	TNRC18 GRID2IP	1.63e-03	47	58	2	7p22.1
Cytoband	1q32	LMOD1 TRAF3IP3	1.78e-03	49	58	2	1q32
Cytoband	17p13.2	TRPV1 ZNF232	2.23e-03	55	58	2	17p13.2
GeneFamily	Proline rich proteins	PRB1 PRB3 PRB4 PRB2	3.76e-10	6	42	4	972
GeneFamily	PDZ domain containing	PTPN4 IL16 GRID2IP MAST4 PCLO DLG3 NOS1	5.45e-08	152	42	7	1220
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ATRX IQSEC2 DLG3	2.52e-04	53	42	3	103
GeneFamily	Zinc fingers CCCH-type	ZC3H4 ZC3H18	2.99e-03	35	42	2	73
Coexpression	BORCZUK_MALIGNANT_MESOTHELIOMA_DN	SEMA3F MAST4 PRB1 LMOD1 TRAF3IP3	3.80e-06	106	58	5	M7988
Coexpression	GSE33374_CD8_ALPHAALPHA_VS_ALPHABETA_CD161_HIGH_TCELL_UP	HOXA4 ATRX GUCY2D AFF1 DLG3 RAI1	5.18e-06	199	58	6	M8538
ToppCell	Bronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PRB1 PRB3 PRB4 PRB2 CDC6 NCMAP	2.19e-07	197	58	6	92a66e3b5ddc3d55527c31e0d9cff15c2203ecfc
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRID2IP MAST4 PRSS53 PCLO AFF1	3.17e-06	174	58	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 PRSS53 PCLO CNGB3 AFF1	3.54e-06	178	58	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	ASK440-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	CCDC88C PTPN4 IL16 FGFBP2 TRAF3IP3	4.39e-06	186	58	5	ce8e63057a99afa0a9cbf27ae7f9a70c0e972b6d
ToppCell	facs-Kidney-nan-18m-Endothelial-fenestrated_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F MFNG PHACTR2 CALD1 RRAS	5.12e-06	192	58	5	777e386a17bba9ec450bb9d64d8a9ab98d9a63ff
ToppCell	facs-Kidney-nan-18m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F MFNG PHACTR2 CALD1 RRAS	5.12e-06	192	58	5	60a2409546525a40a5658e0f9d6a50c37f28bb96
ToppCell	facs-Kidney-nan-18m-Endothelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F MFNG PHACTR2 CALD1 RRAS	5.12e-06	192	58	5	0f9db6091b373334b9beabe0e5782bf2bc54690b
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRB1 PRB3 PRB4 PRB2 NCMAP	5.39e-06	194	58	5	e90f6717e3421f8978d1fc1b2f30dcf69f6fcce7
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	CCDC88C GTF2I CALD1 ATRX NACA	5.66e-06	196	58	5	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	CCDC88C GTF2I CALD1 ATRX NACA	5.66e-06	196	58	5	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	cellseq2\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRB1 PRB3 PRB4 PRB2 LMOD1	5.66e-06	196	58	5	d9e1b8386817a668eca90288b6d0e20be4138bf8
ToppCell	Bronchial-10x5prime-Epithelial-Epi_submucosal-gland\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PRB1 PRB3 PRB4 PRB2 NCMAP	5.81e-06	197	58	5	e2c820c4e4a6cd01ceb020473286e3f5d4e3718e
ToppCell	BLOOD\|World / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	MFNG IL16 FGFBP2 NACA TRAF3IP3	6.10e-06	199	58	5	c2816a840ec3862d22e5efa8f0cdd0208635002d
ToppCell	Tracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PRB1 PRB3 PRB4 PRB2 NCMAP	6.25e-06	200	58	5	e9908b6cba21a59023cf8d0f98fbd1d1f7de6b44
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	RAPH1 PRB1 PRB3 PRB4 PRB2	6.25e-06	200	58	5	61bae10c8b12196d9cee766897971b81cb897191
ToppCell	Dendritic_Cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	IL16 PRSS53 RP1L1 SYN1	4.49e-05	151	58	4	e089bf197ed60e7243160521d4390d4b40a3832b
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C PTPN4 FGFBP2 TRAF3IP3	4.73e-05	153	58	4	d8773ee16c7d3e0834b9f64054d42336d6f9833b
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C PTPN4 FGFBP2 TRAF3IP3	5.10e-05	156	58	4	71f49db7d6da5533ecfcd4eacb50ecf1f30ee712
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|368C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C PTPN4 FGFBP2 TRAF3IP3	5.36e-05	158	58	4	390b9c455ed15a6804613eecfd2776949dfba146
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 MFNG IL16 STAP2	6.05e-05	163	58	4	c21114826bee1b05b411984326fef6b6e0d05316
ToppCell	E12.5-Endothelial-lymphatic_endothelial_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MRC1 MFNG IL16 STAP2	6.05e-05	163	58	4	5d49414432db259a19df50d7944581d00b69f537
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CALD1 LMOD1 TRAF3IP3 CDC6	6.49e-05	166	58	4	26f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCell	facs-Aorta-Heart-24m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZC3H4 SYN1 TRAF3IP3 CDC6	6.64e-05	167	58	4	b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	6.80e-05	168	58	4	696b31bedbc7d40817a733e8c6ec2633404be619
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C PTPN4 FGFBP2 TRAF3IP3	6.96e-05	169	58	4	f06118754fa62c580b4bcbecff6f9e5fdc2106a0
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 PSAP PRSS53 IQSEC2	7.12e-05	170	58	4	067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B2\|343B / Donor, Lineage, Cell class and subclass (all cells)	PTPN4 IL16 FGFBP2 TRAF3IP3	7.28e-05	171	58	4	d1c5540e59c64eb233acab53bfd0d68e922a74bb
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|390C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C PTPN4 FGFBP2 TRAF3IP3	7.28e-05	171	58	4	d6d8ea45b443d95f64720c9bc07d324148f5b239
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SH3PXD2B IL16 CALD1 LMOD1	7.28e-05	171	58	4	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	7.79e-05	174	58	4	7ebf06076946729c1af25109df6066731097c3b1
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	7.79e-05	174	58	4	90961e8839514985712b8b986aec3391bb249ba7
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	7.79e-05	174	58	4	c4b0987d9394f977fe6bc6a4214a6d8d73d0abcc
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MRC1 FKBP15 PSAP SYN1	7.79e-05	174	58	4	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C PTPN4 GTF2I TRAF3IP3	7.79e-05	174	58	4	6ca9433d398aa3b48ecdc522dd545119e7c77dd4
ToppCell	COVID-matDC-\|COVID / Condition, Cell_class and T cell subcluster	CALD1 STAP2 LMOD1 NOS1	7.96e-05	175	58	4	db5e170411dfa62074c4b8311bb8c589d1c4279b
ToppCell	COVID-matDC\|COVID / Condition, Cell_class and T cell subcluster	CALD1 STAP2 LMOD1 NOS1	7.96e-05	175	58	4	e2b638109c9ffd10430e6e134035622b7605ce23
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PHACTR2 CALD1 CNGB3 LMOD1	8.32e-05	177	58	4	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	15-Airway-Immune-Hematopoietic,_Natural_Killer_Cell\|Airway / Age, Tissue, Lineage and Cell class	MFNG IL16 FGFBP2 TRAF3IP3	8.51e-05	178	58	4	0003c3f2561b7a1fd86772bcba59883ba1f17cd2
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FKBP15 PYGO2 BAG3 SMG9	8.51e-05	178	58	4	8151e5d73407fd9cba382b69a2bc707c81790c7f
ToppCell	ASK440-Immune-NK_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	HOXA4 IL16 FGFBP2 TRAF3IP3	8.88e-05	180	58	4	340e750356d23fe9af0e8f298f8a273ff426052f
ToppCell	droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 SH3PXD2B PYGO2 SYN1	9.47e-05	183	58	4	ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCell	Serous\|World / shred by cell class for bronchial biopsy	PRB1 PRB3 PRB4 PRB2	9.67e-05	184	58	4	09d0d1525c11dd326efd942684c03f79d992cf3b
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRB1 PRB3 PRB4 PRB2	9.67e-05	184	58	4	f0cbb5b76e092be4188a9804ef5cf7a83cd7644f
ToppCell	cellseq-Epithelial-Epithelial_Glandular-Serous-Serous\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRB1 PRB3 PRB4 PRB2	9.67e-05	184	58	4	5433ba7bbab553ff668619822d1a9208e15cd59f
ToppCell	droplet-Lung-nan-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 SH3PXD2B PYGO2 SYN1	9.67e-05	184	58	4	3261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.01e-04	186	58	4	71e87c4c755ab607689cb050f5a363cb520a0f53
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SH3PXD2B RAPH1 IQSEC2 STAP2	1.01e-04	186	58	4	c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|390C / Donor, Lineage, Cell class and subclass (all cells)	PTPN4 IL16 FGFBP2 TRAF3IP3	1.03e-04	187	58	4	1e8651e6c547384ace5a66b96c6b24a7f390a7ee
ToppCell	Endothelial-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	HOXA4 SEMA3F CALD1 NOS1	1.03e-04	187	58	4	fd93f3f4b82dae3bf4eef245bfedc2a9e3251b61
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.05e-04	188	58	4	02b3aae071ff1f469d52a4d513a4eb46ae70bba3
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MFNG IL16 FGFBP2 TRAF3IP3	1.05e-04	188	58	4	a2f42a86418a52cd12c3a699ab290d7d86826359
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-osteoclast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SH3PXD2B RAPH1 IQSEC2 STAP2	1.05e-04	188	58	4	762b52f21d2bc5409f86746a904c4358490be9c0
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.09e-04	190	58	4	4240d52a465bc3f8016834b22a35c44ba2b0a9f4
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC88C MFNG IL16 TRAF3IP3	1.09e-04	190	58	4	d83fdc352ebb0c2f2a7c2138bf6e3b7a8ce83a6a
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SH3PXD2B RAPH1 IQSEC2 STAP2	1.12e-04	191	58	4	be2fe2583bdcee0b35c43a347da9c4adb93e30e0
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.12e-04	191	58	4	13460059a0c1ed9f476cef28b8ad4c06349056c6
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SH3PXD2B RAPH1 IQSEC2 STAP2	1.12e-04	191	58	4	4cebaf31d4f09f4ab273a819ad5cbff7d9a9b341
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D\|343B / Donor, Lineage, Cell class and subclass (all cells)	PTPN4 IL16 FGFBP2 TRAF3IP3	1.12e-04	191	58	4	2bd4ba4aaa0f4885079516156b409df527ab22f4
ToppCell	IPF-Lymphoid-NK\|World / Disease state, Lineage and Cell class	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.12e-04	191	58	4	f206159b9d5e84cf14a65bfdc008895cec5a8081
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	8f0d37d204958aaf77214a6c75bef2bf5498f11c
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	0cada869e852d4b9a60e95886c927fc24d072364
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	f1a843e22bdef9fdc063c21f096269eb4af590a8
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	de937cc101a654c6699090beb7e24c430d5a19bf
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	edb0f4fff3a9d7af5e71d3a282f358cf04ca1435
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	fd7f034f0d5a5d577dc9e26a15856f5defbdef43
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	1922b0350d3375e67c314dbce8074e5cf986f2ef
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	97c197643e59835c6d45dde9e549c9a1b1bb7288
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	8f7e0ddf3855199b0aa63b633dc2948f03607933
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	MRC1 FKBP15 PSAP RREB1	1.14e-04	192	58	4	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	a0bd4a0d00246af4f6645e66a0dedfe36882cc60
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-NK-NK-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	6d7dd35869d86c3e991a61e17825053a3bfab44d
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.14e-04	192	58	4	a4d161e3d48bc020e687808b352325ef9d1cc1f3
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)-SMG_serous_(bronchial)_L.0.6.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.14e-04	192	58	4	48b69d6f46e583378186d2993a202f9584688bfa
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	MRC1 FKBP15 SH3PXD2B PSAP	1.16e-04	193	58	4	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SH3PXD2B IL16 CALD1 LMOD1	1.16e-04	193	58	4	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell-SMG_serous_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.16e-04	193	58	4	56145861ef5e7655db9ad0d11b82f72dcadf285d
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_tracheobronchial_serous_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.16e-04	193	58	4	3d1710a6060d3a70994a206334ccb16cd63e5f20
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPN4 MFNG FGFBP2 TRAF3IP3	1.16e-04	193	58	4	00349d176fb6a46cbcc99c41d975651b6e9aaad4
ToppCell	COVID-CD8-CD8_1\|COVID / Condition, Cell_class and T cell subcluster	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.16e-04	193	58	4	221690901cb214c8ee186ff527c80dcc52d1fb1c
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3F CALD1 RRAS NOS1	1.19e-04	194	58	4	f8a59bd4609d147d8a706bf606e9e8173c9992a3
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	8bfd7c5be518b81b17913139bcb3ebea01f48dd5
ToppCell	metastatic_Lymph_Node-T/NK_cells-CD8_low_T\|metastatic_Lymph_Node / Location, Cell class and cell subclass	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	b0595b98332fee7936e455240bbefe72b79c98b8
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	e75b0e3d2c49311b20346af67b3be936a39243b2
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	23174bfd1159619b2660f9bc07c99ba771f6a4e7
ToppCell	390C-Endothelial_cells-Endothelial-B_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	SEMA3F CALD1 RRAS NOS1	1.19e-04	194	58	4	04b1acc2e879feafb43f75435281c5acd8d23be2
ToppCell	3'-Broncho-tracheal_SMG-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.19e-04	194	58	4	f1d057c4bf57e75ad5a821e5f3de335dbff69062
ToppCell	3'-Broncho-tracheal_SMG\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.19e-04	194	58	4	42558822d7e260e7d8cf2539f1f7426e5774edfb
ToppCell	Endothelial-A-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	HOXA4 SEMA3F CALD1 NOS1	1.19e-04	194	58	4	e656ac5539e59e321b46706cb8cc423b2c3358a0
ToppCell	ICU-SEP-Lymphocyte-T_NK-CD4_CTL\|ICU-SEP / Disease, Lineage and Cell Type	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	ca7f5ae54313b3728d6e6e4f801dc420d5406930
ToppCell	3'-Broncho-tracheal_SMG-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRB1 PRB3 PRB4 PRB2	1.19e-04	194	58	4	0d97dee07846416c77a861994912a9207f29ceb3
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	fa72c2f3e6b8bfc2ef126deb219ec6a44809385b
ToppCell	cellseq-Epithelial-Epithelial_Glandular\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PRB1 PRB3 PRB4 PRB2	1.19e-04	194	58	4	d0fb1ff5cf0738881e114a58f0b27489f781d72b
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-Intermediate_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	54c809ed134ed828f3653603cf821cc303240f36
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88C PTPN4 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	f0707601883b234ed477c7704ca9a88efaefc3fd
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	bc7c4efe2a82057fb95582da983e36f413990902
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	b43788e458a80ab93f485f4577370aec448ad95e
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_C\|343B / Donor, Lineage, Cell class and subclass (all cells)	PTPN4 IL16 FGFBP2 TRAF3IP3	1.19e-04	194	58	4	fe36cf5cf8ebd761d29ad23ee074128a12d32031
ToppCell	BAL-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTPN4 IL16 NACA TRAF3IP3	1.21e-04	195	58	4	caa3669739974b63470f7e557df96e8d3844dd84
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN4 IL16 FGFBP2 TRAF3IP3	1.21e-04	195	58	4	e1b7ef4ba2ab14d3c839b6305d91efcfd0826220
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A\|343B / Donor, Lineage, Cell class and subclass (all cells)	PTPN4 IL16 FGFBP2 TRAF3IP3	1.21e-04	195	58	4	1af6fd96634236d5910fd085ff2d532862303d6b
Computational	Genes in the cancer module 248.	IL16 PRB4 GUCY2D DLG3 NOS1	5.60e-05	129	35	5	MODULE_248
Computational	Actin cytoskeleton binding.	CALD1 SYN1 LMOD1	1.21e-04	30	35	3	MODULE_524
Computational	Genes in the cancer module 419.	CALD1 SYN1 LMOD1	1.77e-04	34	35	3	MODULE_419
Computational	Genes in the cancer module 397.	SEMA3F PHACTR2 PYGO2 CABIN1	6.11e-04	121	35	4	MODULE_397
Drug	Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; HL60; HT_HG-U133A	TDRD7 SETD1A PTPN4 PHACTR2 AFF1 TRAF3IP3	9.08e-06	191	58	6	2499_DN
Drug	Methacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	SETD1A C14orf93 IL16 CALD1 PRB4 DLG3	1.11e-05	198	58	6	6248_UP
Drug	Cyproterone acetate [427-51-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	FKBP15 C14orf93 TRPV1 GTF2I ATRX DLG3	1.15e-05	199	58	6	6806_DN
Disease	Smith-Magenis syndrome	IQSEC2 RAI1	2.27e-05	4	58	2	C0795864
Disease	Mental Retardation, X-Linked	ATRX IQSEC2 DLG3	2.54e-05	29	58	3	C1136249
Disease	Growth Disorders	SH3PXD2B ATRX RAI1	4.91e-05	36	58	3	C0018273
Disease	HWESASXX measurement	CNGB3 RREB1	7.92e-05	7	58	2	EFO_0021147
Disease	RASopathy (implicated_via_orthology)	RRAS RREB1	1.35e-04	9	58	2	DOID:0080690 (implicated_via_orthology)
Disease	non-syndromic X-linked intellectual disability (implicated_via_orthology)	IQSEC2 DLG3	1.35e-04	9	58	2	DOID:0050776 (implicated_via_orthology)
Disease	Neurobehavioral Manifestations	NOS1 RAI1	2.47e-04	12	58	2	C0525041
Disease	seborrheic dermatitis	TNRC18 MAST4	7.05e-04	20	58	2	EFO_1000764
Disease	malignant astrocytoma (is_marker_for)	IL16 ATRX	9.36e-04	23	58	2	DOID:3069 (is_marker_for)
Disease	Unipolar Depression	RAPH1 PCLO DLG3 NOS1	1.70e-03	259	58	4	C0041696
Disease	Mental Retardation, X-Linked 1	IQSEC2 DLG3	1.81e-03	32	58	2	C2931498

Protein segments in the cluster

Peptide	Gene	Start	Entry
FEPPPPKKQNGAIGR	DHX15	401	O43143
PTKGNGEPATKLPPP	RAI1	1281	Q7Z5J4
PGGKKPPPTPQRNSS	RAPH1	966	Q70E73
TPGDGKPPALPPKQS	PTPN4	456	P29074
GFNKPIPKPPDLQPG	GUCY2D	1061	Q02846
PPGTANPPSANPKAK	IQSEC2	1466	Q5JU85
PPAIGGQPGPPAKKE	CCDC88C	1706	Q9P219
PGPAKPPAQPSGLTK	PCLO	326	Q9Y6V0
PGTTKPPAQPLGPAK	PCLO	356	Q9Y6V0
GPAKPPTQQVGTPKP	PCLO	406	Q9Y6V0
STKPPPQQPGPAKPS	PCLO	506	Q9Y6V0
PAKPSPQQPGSTKPP	PCLO	516	Q9Y6V0
PKNSPKKGGAPAAPP	LMOD1	521	P29536
GPESPGEPQPPQLKK	FKBP15	1111	Q5T1M5
GRQPNQKTLPPGPDP	IL16	926	Q14005
PTAKPTQPGPRPGGN	FGFBP2	181	Q9BYJ0
GKQAPVPPPKPASRN	PHACTR2	201	O75167
PKGPKPTAPSAVGPN	NCMAP	66	Q5T1S8
NGLAPRPPGQDPAKK	NOS1	176	P29475
PPAPPSTGRKQGKAG	PYGO2	21	Q9BRQ0
PPPMRSKNPGPSQGK	ATRX	2476	P46100
FGTQKPAKPVPGPEP	GRID2IP	871	A4D2P6
PEDGQEGLPQPKKPP	CABIN1	1696	Q9Y6J0
PKPGTPAAIQPDSPK	GFY	306	I3L273
PETGPENGTKLPPPR	C14orf93	236	Q9H972
PPCSPPKQGKKENGP	CDC6	71	Q99741
PPKPVPGKSTPKLNG	DLG3	86	Q92796
GPGPQKPPTEADKPN	MAST4	2421	O15021
PQPPVPEPANAGKRK	GTF2I	331	P78347
QPENKPESKPGPVGP	BAG3	316	O95817
GRPPQPEQPPAQAKG	HOXA4	111	Q00056
QGTPELSQPNPGPPK	MFNG	36	O00587
GKPQGPPPQGDKSRS	PRB2	96	P02812
PGKPQGPPPQGDNKS	PRB2	156	P02812
PGKPERPPPQGGNQS	PRB4	96	P10163
QSQGTPPPPGKPEGR	PRB4	151	P10163
PGKPERPPPQGGNQS	PRB4	201	P10163
HPGKPEGPPPQEGNK	PRB4	221	P10163
QQEGNKPQGPPPPGK	PRB4	251	P10163
KGQTPKPEPTPAPQD	MRC1	781	P22897
PQKPPGPAGPTRQAS	SYN1	591	P17600
PGPAGRPKPQLAQKP	SYN1	626	P17600
GGPPQKPAPSSQRKP	UTP18	36	Q9Y5J1
PPVGPKPEPKVFNGG	STAP2	351	Q9UGK3
PGAPRSPEPQDQKKP	SEMA3F	761	Q13275
PPAAPAPPKGEKEGQ	SMG9	126	Q9H0W8
LPGPKQTPPLKGCPT	TDRD7	321	Q8NHU6
PPQAKFPGPASRKAP	SETD1A	1186	O15047
GNKSPAPKPSDLRPG	CALD1	756	Q05682
PVPSLPNGNSKPGKP	AFF1	941	P51825
KGPQQGKGPEPAKPP	CMTM2	221	Q8TAZ6
PGKEGPNSPQNKPPA	CNGB3	106	Q9NQW8
NQSQGPPPRPGKPEG	PRB3	66	Q04118
GNQSQGPPPRPGKPE	PRB3	86	Q04118
NQSQGPPPRPGKPEG	PRB3	171	Q04118
GNQSQGPPPRPGKPE	PRB3	191	Q04118
RGPGPPKPQEGNTVP	PRSS53	31	Q2L4Q9
SPGKKTPAPQPQAPP	TNRC18	2716	O15417
KPQGPPPQGDKSRSP	PRB1	76	P04280
PGKPQGPPPQGDKSQ	PRB1	196	P04280
GPPPQGDKSQSPRSP	PRB1	201	P04280
RSPPGKPQGPPQQEG	PRB1	336	P04280
AGGLPPQDTPIKKPP	TRAF3IP3	146	Q9Y228
GPKPGFPEPTNNTPK	STAU2	396	Q9NUL3
DKKPPKTPSGPGRPQ	RP1L1	106	Q8IWN7
DGDPNSRPPPAKPQL	TRPV1	26	Q8NER1
SPQGIKSPSKPPGPN	RREB1	36	Q92766
KKNSGEPLPPKPGPG	SH3PXD2B	276	A1X283
PQDGPRSKPQPKDNG	PSAP	181	P07602
KQGINPLPKPPPGVG	ZC3H4	501	Q9UPT8
GPEPKDKGSLPQPPI	ZNF232	196	Q9UNY5
QELPPSPPSAPRKKG	RRAS	196	P10301
GKPKPRSPQPPSRQA	ZC3H18	481	Q86VM9
PKEGPATPAPKQAPA	NACA	896	E9PAV3