Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-chloroallyl aldehyde dehydrogenase activity	ALDH3B1 ALDH3B2 ALDH3A2	5.13e-07	7	50	3	GO:0004028
GeneOntologyMolecularFunction	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	ALDH3B1 ALDH3B2 ALDH3A2	1.23e-06	9	50	3	GO:0043878
GeneOntologyMolecularFunction	aldehyde dehydrogenase (NAD+) activity	ALDH3B1 ALDH3B2 ALDH3A2	6.58e-06	15	50	3	GO:0004029
GeneOntologyMolecularFunction	aldehyde dehydrogenase [NAD(P)+] activity	ALDH3B1 ALDH3B2 ALDH3A2	9.80e-06	17	50	3	GO:0004030
GeneOntologyMolecularFunction	transforming growth factor beta receptor binding	SMURF1 USP15 SMURF2	6.32e-05	31	50	3	GO:0005160
GeneOntologyMolecularFunction	diacylglycerol O-acyltransferase activity	MOGAT1 DGAT2	1.70e-04	8	50	2	GO:0004144
GeneOntologyMolecularFunction	2-acylglycerol O-acyltransferase activity	MOGAT1 DGAT2	1.70e-04	8	50	2	GO:0003846
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	ALDH3B1 ALDH3B2 ALDH3A2	2.36e-04	48	50	3	GO:0016620
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the aldehyde or oxo group of donors	ALDH3B1 ALDH3B2 ALDH3A2	3.73e-04	56	50	3	GO:0016903
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	AMDHD1 OPLAH	7.21e-04	16	50	2	GO:0016812
GeneOntologyMolecularFunction	SMAD binding	SMURF1 USP15 SMURF2	1.31e-03	86	50	3	GO:0046332
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC2A14 SLC5A2	1.78e-03	25	50	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC2A14 SLC5A2	1.78e-03	25	50	2	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC2A14 SLC5A2	2.07e-03	27	50	2	GO:0015145
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	TNKS TNKS2	2.23e-03	28	50	2	GO:0003950
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC2A14 SLC5A2	2.39e-03	29	50	2	GO:0051119
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	TNKS TNKS2	2.56e-03	30	50	2	GO:1990404
GeneOntologyMolecularFunction	acylglycerol O-acyltransferase activity	MOGAT1 DGAT2	2.91e-03	32	50	2	GO:0016411
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC2A14 SLC5A2	4.96e-03	42	50	2	GO:0015144
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT2A3 GBE1 TNKS TNKS2	5.80e-03	288	50	4	GO:0016757
GeneOntologyBiologicalProcess	primary alcohol metabolic process	CYP1B1 DGAT2 ALDH3B1 ALDH3B2 ALDH3A2	5.75e-06	106	50	5	GO:0034308
GeneOntologyBiologicalProcess	cellular response to oleic acid	DGAT2 CPS1	1.73e-05	3	50	2	GO:0071400
GeneOntologyBiologicalProcess	response to oleic acid	DGAT2 CPS1	5.73e-05	5	50	2	GO:0034201
GeneOntologyBiologicalProcess	aldehyde metabolic process	CYP1B1 ALDH3B1 ALDH3B2 ALDH3A2	8.27e-05	95	50	4	GO:0006081
GeneOntologyBiologicalProcess	cellular catabolic process	KLHL3 CYP1B1 ADHFE1 ATP6V0B SMURF1 AMDHD1 NIPSNAP2 ZNRF1 CPS1 ALDH3B1 ALDH3B2	1.65e-04	1253	50	11	GO:0044248
GeneOntologyBiologicalProcess	diacylglycerol biosynthetic process	MOGAT1 DGAT2	2.56e-04	10	50	2	GO:0006651
GeneOntologyBiologicalProcess	protein poly-ADP-ribosylation	TNKS TNKS2	3.12e-04	11	50	2	GO:0070212
GeneOntologyBiologicalProcess	protein auto-ADP-ribosylation	TNKS TNKS2	3.12e-04	11	50	2	GO:0070213
GeneOntologyBiologicalProcess	membrane lipid catabolic process	CYP1B1 ALDH3B1 ALDH3B2	3.22e-04	55	50	3	GO:0046466
Domain	Aldehyde_DH_NAD(P)	ALDH3B1 ALDH3B2 ALDH3A2	6.78e-08	4	49	3	IPR012394
Domain	Calcineurin-like_Pesterase	MPPED2 MPPED1	6.74e-06	2	49	2	IPR024201
Domain	Ald_DH_CS_GLU	ALDH3B1 ALDH3B2 ALDH3A2	9.28e-06	16	49	3	IPR029510
Domain	Ald_DH_CS_CYS	ALDH3B1 ALDH3B2 ALDH3A2	1.12e-05	17	49	3	IPR016160
Domain	ALDEHYDE_DEHYDR_GLU	ALDH3B1 ALDH3B2 ALDH3A2	1.35e-05	18	49	3	PS00687
Domain	ALDEHYDE_DEHYDR_CYS	ALDH3B1 ALDH3B2 ALDH3A2	1.35e-05	18	49	3	PS00070
Domain	-	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	3.40.605.10
Domain	Aldedh	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	PF00171
Domain	Aldehyde_DH_dom	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	IPR015590
Domain	-	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	3.40.309.10
Domain	Ald_DH_C	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	IPR016163
Domain	Ald_DH_N	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	IPR016162
Domain	Ald_DH/histidinol_DH	ALDH3B1 ALDH3B2 ALDH3A2	1.60e-05	19	49	3	IPR016161
Domain	DAGAT	MOGAT1 DGAT2	1.40e-04	7	49	2	PF03982
Domain	DAGAT	MOGAT1 DGAT2	1.40e-04	7	49	2	IPR007130
Domain	Poly(ADP-ribose)pol_cat_dom	TNKS TNKS2	8.94e-04	17	49	2	IPR012317
Domain	PARP_CATALYTIC	TNKS TNKS2	8.94e-04	17	49	2	PS51059
Domain	PARP	TNKS TNKS2	8.94e-04	17	49	2	PF00644
Domain	-	TNKS TNKS2	8.94e-04	17	49	2	3.90.228.10
Domain	WGR_domain	TNKS TNKS2	1.79e-03	24	49	2	IPR008893
Domain	HECT	SMURF1 SMURF2	2.27e-03	27	49	2	PF00632
Domain	HECTc	SMURF1 SMURF2	2.27e-03	27	49	2	SM00119
Domain	HECT_dom	SMURF1 SMURF2	2.27e-03	27	49	2	IPR000569
Domain	HECT	SMURF1 SMURF2	2.27e-03	27	49	2	PS50237
Domain	Calcineurin-like_PHP_ApaH	MPPED2 MPPED1	2.44e-03	28	49	2	IPR004843
Domain	Metallophos	MPPED2 MPPED1	2.44e-03	28	49	2	PF00149
Domain	Metallo-depent_PP-like	MPPED2 MPPED1	2.80e-03	30	49	2	IPR029052
Domain	-	MPPED2 MPPED1	2.80e-03	30	49	2	3.60.21.10
Domain	Abhydrolase_1	SERHL2 SERHL	2.99e-03	31	49	2	PF00561
Domain	AB_hydrolase_1	SERHL2 SERHL	3.38e-03	33	49	2	IPR000073
Domain	Gal_Oxidase_b-propeller	RABEPK KLHL3	3.59e-03	34	49	2	IPR015916
Domain	SAM_2	TNKS TNKS2	5.69e-03	43	49	2	PF07647
Domain	WW	SMURF1 SMURF2	6.76e-03	47	49	2	PF00397
Domain	WW	SMURF1 SMURF2	7.04e-03	48	49	2	SM00456
Domain	WW_DOMAIN_2	SMURF1 SMURF2	7.92e-03	51	49	2	PS50020
Domain	WW_DOMAIN_1	SMURF1 SMURF2	7.92e-03	51	49	2	PS01159
Domain	WW_dom	SMURF1 SMURF2	8.22e-03	52	49	2	IPR001202
Domain	USP_CS	USP44 USP15	1.30e-02	66	49	2	IPR018200
Pathway	KEGG_HISTIDINE_METABOLISM	AMDHD1 ALDH3B1 ALDH3B2 ALDH3A2	9.10e-07	29	37	4	M12524
Pathway	REACTOME_SPHINGOLIPID_CATABOLISM	ALDH3B1 ALDH3B2 ALDH3A2	3.60e-06	12	37	3	M48264
Pathway	REACTOME_SPHINGOLIPID_CATABOLISM	ALDH3B1 ALDH3B2 ALDH3A2	3.60e-06	12	37	3	MM17238
Pathway	KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	CYP1B1 UGT2A3 ALDH3B1 ALDH3B2	3.25e-05	70	37	4	M16794
Pathway	REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	SMURF1 USP15 SMURF2	4.15e-05	26	37	3	M628
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP44 TNKS TNKS2 USP15 SMURF2	1.33e-04	191	37	5	MM15289
Pathway	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	SMURF1 USP15 SMURF2	2.49e-04	47	37	3	M646
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP44 TNKS TNKS2 USP15 SMURF2	2.62e-04	221	37	5	M27578
Pathway	REACTOME_DEGRADATION_OF_AXIN	TNKS TNKS2 SMURF2	3.56e-04	53	37	3	MM15152
Pathway	REACTOME_DEGRADATION_OF_AXIN	TNKS TNKS2 SMURF2	3.98e-04	55	37	3	M27398
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A6 SLC2A14	4.35e-04	12	37	2	MM1526
Pathway	REACTOME_TRIGLYCERIDE_BIOSYNTHESIS	MOGAT1 DGAT2	4.35e-04	12	37	2	MM15447
Pathway	KEGG_GLYCOLYSIS_GLUCONEOGENESIS	ALDH3B1 ALDH3B2 ALDH3A2	5.66e-04	62	37	3	M11521
Pathway	REACTOME_DEUBIQUITINATION	USP44 TNKS TNKS2 USP15 SMURF2	5.72e-04	262	37	5	MM15286
Pathway	REACTOME_TRIGLYCERIDE_BIOSYNTHESIS	MOGAT1 DGAT2	5.98e-04	14	37	2	M619
Pathway	BIOCARTA_EFP_PATHWAY	SMURF1 SMURF2	7.86e-04	16	37	2	M22011
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	UGT2A3 ALDH3B1 ALDH3B2	8.76e-04	72	37	3	M9257
Pathway	KEGG_PHENYLALANINE_METABOLISM	ALDH3B1 ALDH3B2	9.99e-04	18	37	2	M16650
Pathway	REACTOME_DEUBIQUITINATION	USP44 TNKS TNKS2 USP15 SMURF2	1.04e-03	299	37	5	M27574
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A14 SLC5A2	1.11e-03	19	37	2	MM14718
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A14 SLC5A2	1.36e-03	21	37	2	M27058
Pathway	WP_NAD_BIOSYNTHETIC_PATHWAYS	TNKS TNKS2	1.50e-03	22	37	2	M39704
Pathway	REACTOME_TRIGLYCERIDE_METABOLISM	MOGAT1 DGAT2	1.64e-03	23	37	2	MM15575
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	MOGAT1 DGAT2	1.64e-03	23	37	2	MM15890
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ALDH3B1 ALDH3B2 ALDH3A2	1.78e-03	92	37	3	MM15086
Pathway	WP_TRIACYLGLYCERIDE_SYNTHESIS	MOGAT1 DGAT2	1.78e-03	24	37	2	M39692
Pathway	REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	SMURF1 USP15 SMURF2	1.89e-03	94	37	3	M1041
Pathway	KEGG_ASCORBATE_AND_ALDARATE_METABOLISM	UGT2A3 ALDH3A2	1.94e-03	25	37	2	M605
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ALDH3B1 ALDH3B2 ALDH3A2	2.74e-03	107	37	3	M14857
Pathway	REACTOME_SIGNALING_BY_BMP	SMURF1 SMURF2	2.97e-03	31	37	2	M1662
Pathway	REACTOME_SIGNALING_BY_BMP	SMURF1 SMURF2	2.97e-03	31	37	2	MM14789
Pathway	REACTOME_SIGNALING_BY_WNT	SMURF1 TNKS TNKS2 SMURF2	3.43e-03	239	37	4	MM14756
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	TNKS TNKS2	3.57e-03	34	37	2	M27405
Pathway	REACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES	CYP1B1 OPLAH	3.57e-03	34	37	2	M27461
Pubmed	Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification.	ALDH3B1 ALDH3B2 ALDH3A2	1.19e-08	4	51	3	25286108
Pubmed	Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.	TNKS TNKS2 PCBP1	1.07e-06	14	51	3	35733260
Pubmed	Tankyrase is necessary for canonical Wnt signaling during kidney development.	TNKS TNKS2	2.11e-06	2	51	2	20549720
Pubmed	The 239AB gene on chromosome 22: a novel member of an ancient gene family.	MPPED2 MPPED1	2.11e-06	2	51	2	9266672
Pubmed	Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.	TNKS TNKS2	2.11e-06	2	51	2	18612384
Pubmed	Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.	TNKS TNKS2	2.11e-06	2	51	2	15795250
Pubmed	Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.	TNKS TNKS2	2.11e-06	2	51	2	28723574
Pubmed	Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.	TNKS TNKS2	2.11e-06	2	51	2	27494558
Pubmed	Regulation of tankyrase activity by a catalytic domain dimer interface.	TNKS TNKS2	2.11e-06	2	51	2	30055800
Pubmed	Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.	SERHL2 SERHL	2.11e-06	2	51	2	11352564
Pubmed	Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome.	ALDH3B2 ALDH3A2	2.11e-06	2	51	2	34370553
Pubmed	The functions and regulation of Smurfs in cancers.	SMURF1 SMURF2	2.11e-06	2	51	2	31899247
Pubmed	cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.	MPPED2 MPPED1	2.11e-06	2	51	2	8666403
Pubmed	Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.	TNKS TNKS2	2.11e-06	2	51	2	18026951
Pubmed	Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.	SMURF1 SMURF2	2.11e-06	2	51	2	18927080
Pubmed	Structural insights into SAM domain-mediated tankyrase oligomerization.	TNKS TNKS2	2.11e-06	2	51	2	27328430
Pubmed	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.	TNKS TNKS2	2.11e-06	2	51	2	29263426
Pubmed	Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.	TNKS TNKS2	2.11e-06	2	51	2	24291818
Pubmed	Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.	TNKS TNKS2	2.11e-06	2	51	2	24116873
Pubmed	SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.	SMURF1 SMURF2	2.11e-06	2	51	2	33090007
Pubmed	Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.	ALDH3B1 ALDH3B2	2.11e-06	2	51	2	9161417
Pubmed	Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.	TNKS TNKS2	6.32e-06	3	51	2	33361107
Pubmed	Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.	TNKS TNKS2	6.32e-06	3	51	2	32442396
Pubmed	USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.	USP15 SMURF2	6.32e-06	3	51	2	26435193
Pubmed	Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.	TNKS TNKS2	6.32e-06	3	51	2	11739745
Pubmed	Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.	TNKS TNKS2	6.32e-06	3	51	2	26246473
Pubmed	Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.	MOGAT1 DGAT2	6.32e-06	3	51	2	11481335
Pubmed	Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.	TNKS TNKS2	6.32e-06	3	51	2	25939383
Pubmed	Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma.	SMURF1 SMURF2	6.32e-06	3	51	2	37537194
Pubmed	Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.	TNKS TNKS2	6.32e-06	3	51	2	27441654
Pubmed	The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.	SMURF1 SMURF2	6.32e-06	3	51	2	23475958
Pubmed	Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.	SMURF1 SMURF2	6.32e-06	3	51	2	25051198
Pubmed	USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.	SMURF1 SMURF2	6.32e-06	3	51	2	30244169
Pubmed	Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.	TNKS TNKS2	6.32e-06	3	51	2	33923443
Pubmed	Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice.	SMURF1 SMURF2	6.32e-06	3	51	2	15173588
Pubmed	TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.	TNKS TNKS2	6.32e-06	3	51	2	11454873
Pubmed	Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.	TNKS TNKS2	6.32e-06	3	51	2	21251231
Pubmed	Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.	SMURF1 SMURF2	6.32e-06	3	51	2	24925320
Pubmed	TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.	SMURF1 USP15 SMURF2	1.17e-05	30	51	3	23973329
Pubmed	Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis.	SMURF1 SMURF2	1.26e-05	4	51	2	30566427
Pubmed	Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.	TNKS TNKS2	1.26e-05	4	51	2	30260955
Pubmed	PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.	TNKS TNKS2	1.26e-05	4	51	2	38272024
Pubmed	Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.	SMURF1 SMURF2	1.26e-05	4	51	2	34370213
Pubmed	E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.	TNKS TNKS2	1.26e-05	4	51	2	26513298
Pubmed	Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.	SMURF1 SMURF2	1.26e-05	4	51	2	16373342
Pubmed	Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.	TNKS TNKS2	1.26e-05	4	51	2	36383218
Pubmed	Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.	TNKS TNKS2	1.26e-05	4	51	2	11278563
Pubmed	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation.	SMURF1 SMURF2	1.26e-05	4	51	2	27086113
Pubmed	The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).	TNKS TNKS2	1.26e-05	4	51	2	11854288
Pubmed	The WW1 Domain Enhances Autoinhibition in Smurf Ubiquitin Ligases.	SMURF1 SMURF2	1.26e-05	4	51	2	31628949
Pubmed	Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.	ADHFE1 DGAT2 AMDHD1	1.72e-05	34	51	3	15221005
Pubmed	Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).	TNKS TNKS2	2.10e-05	5	51	2	11802774
Pubmed	An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.	SMURF1 SMURF2	2.10e-05	5	51	2	28839186
Pubmed	Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts.	SMURF1 SMURF2	2.10e-05	5	51	2	14722617
Pubmed	Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.	SMURF1 SMURF2	2.10e-05	5	51	2	21402695
Pubmed	Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.	TNKS TNKS2	2.10e-05	5	51	2	35362478
Pubmed	NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.	SMURF1 SMURF2	2.10e-05	5	51	2	28798345
Pubmed	Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.	SMURF1 SMURF2	2.10e-05	5	51	2	20937913
Pubmed	Inhibition of HECT E3 ligases as potential therapy for COVID-19.	SMURF1 SMURF2	2.10e-05	5	51	2	33762578
Pubmed	The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.	TNKS TNKS2	2.10e-05	5	51	2	22473005
Pubmed	Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.	MOGAT1 DGAT2	2.10e-05	5	51	2	12077311
Pubmed	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.	SMURF1 SMURF2	3.15e-05	6	51	2	21897371
Pubmed	Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.	TNKS TNKS2	3.15e-05	6	51	2	19759537
Pubmed	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.	TNKS TNKS2	3.15e-05	6	51	2	21799911
Pubmed	ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.	SMURF1 SMURF2	3.15e-05	6	51	2	28049720
Pubmed	Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.	TNKS TNKS2	3.15e-05	6	51	2	26845027
Pubmed	Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.	SMURF1 SMURF2	3.15e-05	6	51	2	19318350
Pubmed	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.	SMURF1 SMURF2	3.15e-05	6	51	2	22921829
Pubmed	Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.	TNKS TNKS2	3.15e-05	6	51	2	34128958
Pubmed	Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.	SMURF1 SMURF2	3.15e-05	6	51	2	32361710
Pubmed	Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.	TNKS TNKS2	3.15e-05	6	51	2	10988299
Pubmed	Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.	SMURF1 SMURF2	3.15e-05	6	51	2	23781096
Pubmed	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.	SMURF1 SMURF2	4.41e-05	7	51	2	14701756
Pubmed	A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.	SMURF1 SMURF2	4.41e-05	7	51	2	30587574
Pubmed	SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.	SMURF1 SMURF2	4.41e-05	7	51	2	27292644
Pubmed	The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function.	SMURF1 SMURF2	4.41e-05	7	51	2	28169289
Pubmed	Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.	TNKS TNKS2	4.41e-05	7	51	2	22153076
Pubmed	Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.	TNKS TNKS2	4.41e-05	7	51	2	25547115
Pubmed	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.	TNKS TNKS2	4.41e-05	7	51	2	31554794
Pubmed	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.	TNKS TNKS2	4.41e-05	7	51	2	21478859
Pubmed	Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals.	MOGAT1 DGAT2	5.87e-05	8	51	2	14970677
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	SMURF1 SMURF2	5.87e-05	8	51	2	19307600
Pubmed	Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.	SMURF1 SMURF2	5.87e-05	8	51	2	28881580
Pubmed	USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.	USP15 SMURF2	5.87e-05	8	51	2	22344298
Pubmed	Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.	SMURF1 SMURF2	5.87e-05	8	51	2	20484049
Pubmed	Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis.	TNKS TNKS2	7.54e-05	9	51	2	19766477
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	TNKS TNKS2	7.54e-05	9	51	2	12080061
Pubmed	Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.	SMURF1 SMURF2	7.54e-05	9	51	2	29659741
Pubmed	Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).	SMURF1 SMURF2	9.42e-05	10	51	2	15221015
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	SMURF1 SMURF2	9.42e-05	10	51	2	25092867
Pubmed	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.	SMURF1 SMURF2	9.42e-05	10	51	2	15138260
Pubmed	Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.	SMURF1 SMURF2	1.15e-04	11	51	2	17996703
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	SMURF1 SMURF2	1.15e-04	11	51	2	22773947
Pubmed	Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.	SMURF1 PCBP1	1.15e-04	11	51	2	28963376
Pubmed	Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study.	TNKS TNKS2	1.15e-04	11	51	2	20937264
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	SMURF1 SMURF2	1.38e-04	12	51	2	24107629
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	CYP1B1 ALDH3B1 ALDH3B2 ALDH3A2	1.87e-04	193	51	4	19343046
Pubmed	TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.	SMURF1 SMURF2	1.90e-04	14	51	2	21791611
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	SMURF1 SMURF2	1.90e-04	14	51	2	26147758
Pubmed	Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer.	SMURF1 SMURF2	1.90e-04	14	51	2	29263404
Interaction	AXIN1 interactions	USP44 SMURF1 TNKS TNKS2 USP15 SMURF2	2.63e-06	166	48	6	int:AXIN1
GeneFamily	Aldehyde dehydrogenases	ALDH3B1 ALDH3B2 ALDH3A2	4.34e-06	19	31	3	398
GeneFamily	Diacylglycerol O-acyltransferase 2 family	MOGAT1 DGAT2	7.92e-05	8	31	2	1235
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	TNKS TNKS2	3.81e-04	17	31	2	684
GeneFamily	Ubiquitin specific peptidases	USP44 USP15	4.14e-03	56	31	2	366
GeneFamily	Sterile alpha motif domain containing	TNKS TNKS2	9.94e-03	88	31	2	760
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	USP44 ADHFE1 SLC2A14 TNKS CPS1	6.76e-07	145	51	5	e808502fa52baf1c400f3c9b918a167127e78af9
Computational	Oxidoreductases.	ALDH3B1 ALDH3B2 ALDH3A2	9.38e-06	14	33	3	MODULE_464
Computational	Genes in the cancer module 194.	ALDH3B1 ALDH3B2 ALDH3A2	1.17e-05	15	33	3	MODULE_194
Computational	Oxidoreductases.	ALDH3B1 ALDH3B2 ALDH3A2	3.90e-05	22	33	3	MODULE_373
Drug	methylimidazole acetaldehyde	ADHFE1 ALDH3B1 ALDH3B2 ALDH3A2	4.41e-08	17	49	4	CID000193545
Drug	hydroxyl radicals	USP44 CYP1B1 ADHFE1 ATP6V0B MOGAT1 DGAT2 AMDHD1 PDP2 CPS1 ALDH3B1 ALDH3B2 ALDH3A2 USP15 OPLAH	5.44e-07	1341	49	14	CID000000961
Drug	hydride	CYP1B1 ADHFE1 ATP6V0B SLC4A8 TNKS CPS1 ALDH3B1 TNKS2 ALDH3B2 ALDH3A2 SLC5A2	1.23e-06	835	49	11	CID000000783
Drug	trichloroacetic acid	CYP1B1 ADHFE1 PDP2 ALDH3B1 ALDH3B2	3.37e-06	107	49	5	CID000006421
Drug	propionaldehyde	ADHFE1 ALDH3B1 ALDH3B2 ALDH3A2	4.39e-06	51	49	4	CID000000527
Drug	5-methylnicotinamide	ADHFE1 TNKS TNKS2	5.14e-06	16	49	3	CID000065560
Drug	chloral hydrate	CYP1B1 ADHFE1 ALDH3B1 ALDH3B2 ALDH3A2	8.43e-06	129	49	5	CID000002707
Drug	dhmal	ADHFE1 ALDH3B1 ALDH3B2	3.29e-05	29	49	3	CID000151725
Drug	dithiotreitol	ADHFE1 TASP1 TNKS CPS1 TNKS2 ALDH3A2 OPLAH	3.54e-05	430	49	7	CID000019001
Drug	3,4-dihydroxyphenylacetaldehyde	ALDH3B1 ALDH3B2 ALDH3A2	3.65e-05	30	49	3	CID000119219
Drug	coenzyme 1	ADHFE1 AMDHD1 PDP2 TNKS ALDH3B1 TNKS2 ALDH3B2 ALDH3A2	3.68e-05	596	49	8	CID000000925
Drug	CoA group	ADHFE1 MOGAT1 DGAT2 PDP2 CPS1 ALDH3B1 ALDH3A2	3.70e-05	433	49	7	CID000000317
Drug	3-chlorobenzyl alcohol	ADHFE1 ALDH3A2	4.52e-05	5	49	2	CID000070117
Drug	Apomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; MCF7; HT_HG-U133A	SERHL2 CYP1B1 TNKS2 ALDH3B2 SLC5A2	6.30e-05	196	49	5	1505_UP
Drug	phenylacetaldehyde	ADHFE1 ALDH3B1 ALDH3B2 ALDH3A2	6.38e-05	100	49	4	CID000000998
Drug	4-hydroxy-3-methoxymandelaldehyde	ALDH3B1 ALDH3B2	6.77e-05	6	49	2	CID000440729
Drug	octanal	ADHFE1 ALDH3B1 ALDH3A2	6.91e-05	37	49	3	CID000000454
Drug	IEM-611	ADHFE1 ALDH3A2	9.46e-05	7	49	2	CID000039794
Drug	butoxyacetaldehyde	ADHFE1 ALDH3A2	9.46e-05	7	49	2	CID000114858
Drug	phenobarbital	CYP1B1 ADHFE1 UGT2A3 CPS1 ALDH3A2 PCBP1	1.18e-04	360	49	6	CID000004763
Drug	20-CHO-LTB4	ADHFE1 ALDH3A2	1.26e-04	8	49	2	CID006449839
Drug	homovanillin	ALDH3B1 ALDH3B2	1.26e-04	8	49	2	CID000151276
Drug	DL-1,2-anhydro-myo-inositol	GBE1 PCBP1 SLC5A2	1.33e-04	46	49	3	CID000002859
Disease	Sjogren-Larsson syndrome (implicated_via_orthology)	ALDH3B1 ALDH3B2 ALDH3A2	9.12e-08	6	50	3	DOID:14501 (implicated_via_orthology)
Disease	vitamin D measurement	DGAT2 UGT2A3 AMDHD1 CPS1 ZNF587B	2.59e-04	336	50	5	EFO_0004631
Disease	serine measurement, amino acid measurement	NIPSNAP2 CPS1	3.77e-04	17	50	2	EFO_0005134, EFO_0009774
Disease	Impaired glucose tolerance	CYP1B1 METRNL	8.23e-04	25	50	2	C0271650
Disease	macular telangiectasia type 2	NIPSNAP2 CPS1	8.91e-04	26	50	2	EFO_1002009
Disease	serine measurement	NIPSNAP2 CPS1	1.62e-03	35	50	2	EFO_0009774
Disease	kynurenine measurement	GBE1 BRWD1	2.00e-03	39	50	2	EFO_0008529
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	TNKS TNKS2 BRWD1	2.82e-03	166	50	3	EFO_0004530, EFO_0004611
Disease	apolipoprotein A 1 measurement	SERHL2 PDE3A MOGAT1 DGAT2 PDP2 CPS1	3.00e-03	848	50	6	EFO_0004614
Disease	cognitive inhibition measurement	MUC22 USH2A	3.27e-03	50	50	2	EFO_0007969

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSFLMHTAAGAEGGG	COL4A6	1601	Q14031
GASGMGRYHGKFSFD	ALDH3B1	406	P43353
HAAGSHGVSGIFMKY	ERGIC2	281	Q96RQ1
GMGAYHGKHSFDTFS	ALDH3A2	406	P51648
FGGVGHSGMGRYHGK	ALDH3B2	321	P48448
RVMGKGHQHYGFGGE	C7orf31	86	Q8N865
KLMTYFGHFGGANHA	EFCC1	436	Q9HA90
GGFFSQIGQLYMVHH	NIPSNAP2	221	O75323
HSAVAMGKHVYIFGG	RABEPK	246	Q7Z6M1
GSYVVGFAGAMAHTG	OR8B4	146	Q96RC9
MHGHGIGRFSEEEIY	FAXC	246	Q5TGI0
FGFHPHGIMAVGAFG	MOGAT1	106	Q96PD6
KLHVFGGIHEGYGIM	MPPED2	246	Q15777
SHFAMMHGGTGFAGI	PCBP1	246	Q15365
HSEYELAIAGMFGGF	FN3KRP	241	Q9HA64
GELEMGHGGTHGFGY	MUC22	1731	E2RYF6
DSGFTHGHMGYVFSK	PDE3A	791	Q14432
HYFGVGGGVHLFQKF	METTL18	326	O95568
HGDFLFTGHMHFGEA	METRNL	266	Q641Q3
VFGHIHEGYGVMADG	MPPED1	281	O15442
MEFHNGGHVSGIGGF	SLC2A14	1	Q8TDB8
MFGIFDGHGGHACAQ	PDP2	136	Q9P2J9
FDDHGMMVLGCGPYH	CPS1	971	P31327
SMLYHHHGVGQGFSG	GBE1	361	Q04446
MGYHGQGPSDHYRSF	CHD2	1751	O14647
HYFNMIEGQGHGAVF	BRWD1	506	Q9NSI6
GATYMEIHQAGGGIH	AMDHD1	106	Q96NU7
GVVFMAGHVYAVGGF	KLHL3	341	Q9UH77
VSGGRSMAFGHYSEH	CYP1B1	126	Q16678
YVAMDFGGHGLSSHY	SERHL2	61	Q9H4I8
YIFGYHPHGIMGLGA	DGAT2	156	Q96PD7
FGNAGVHLCHGMSYP	ADHFE1	321	Q8IWW8
YVAMDFGGHGLSSHY	SERHL	61	Q9NQF3
GAGFLELHPYMFHGG	USH2A	1721	O75445
LAGEYFHKAAQGGHM	SEL1L3	821	Q68CR1
NAHMGYYETVAGGAG	OPLAH	1111	O14841
GLHEIGHGSFGAVYF	TAOK3	26	Q9H2K8
HGEFMGSACGHHGPY	SLC4A8	676	Q2Y0W8
GSGFHFHLYLMHKGG	EEF1AKMT4	201	P0DPD7
FVGRIMGLAVFHGHY	SMURF1	491	Q9HCE7
MGLAVFHGHYINGGF	SMURF1	496	Q9HCE7
GMAVFHGHYIDGGFT	SMURF2	491	Q9HAU4
GACILMGYAFHEVGG	SLC5A2	211	P31639
MGYAFHEVGGYSGLF	SLC5A2	216	P31639
GFDERHAYIGGMFGA	TNKS	1196	O95271
HAYIGGMFGAGIYFA	TNKS	1201	O95271
YHAGYSMFGAGLTVG	ATP6V0B	131	Q99437
SNHYGGMGGGHYTAF	USP15	881	Q9Y4E8
HKGFDERHAYIGGMF	TNKS2	1041	Q9H2K2
PFQCGGAHYSHGDSM	ZNF587B	206	E7ETH6
THGGMNGIYEAIYHG	UGT2A3	371	Q6UWM9
GGFVLVHAGAGYHSE	TASP1	41	Q9H6P5
MHHGKGFGSGHYTAY	USP44	626	Q9H0E7
APHFGHYRTGGGAMG	ZNRF1	31	Q8ND25
HGFGQLMFADGGTYL	MORN4	26	Q8NDC4