Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF438 ZNF717 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF658B ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B MTF1 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

4.69e-10141213933GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF717 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF658B ZNF623 ZNF416 ZNF786 ZFX ZNF585B ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

4.35e-09145913932GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF717 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF429 ZNF397 ZNF658B ZNF623 ZNF416 ZNF786 ZFX ZNF585B ZNF16 ZNF182 ZNF610 ZNF33B MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF572

1.11e-07124413927GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF717 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF429 ZNF397 ZNF658B ZNF623 ZNF416 ZNF786 ZFX ZNF585B ZNF16 ZNF182 ZNF610 ZNF33B MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF572

1.70e-07127113927GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF717 ZNF585A ZNF658 ZNF268 ZNF658B ZNF786 ZFX ZNF585B RLF ZNF33B MTF1 ZNF624 ZNF841 ZNF91 ZNF782

8.62e-0656013915GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF717 ZNF585A ZNF658 ZNF268 ZNF658B ZNF786 ZFX ZNF585B RLF ZNF33B MTF1 ZNF624 ZNF841 ZNF91 ZNF782

9.79e-0656613915GO:0001216
GeneOntologyMolecularFunctionexonuclease activity

ENPP3 REXO2 PDE12 TDP1 CPSF3

4.60e-04921395GO:0004527
Domainzf-C2H2

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

3.78e-1969313634PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

3.95e-1969413634IPR013087
DomainZINC_FINGER_C2H2_2

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

1.42e-1877513635PS50157
DomainZINC_FINGER_C2H2_1

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

1.54e-1877713635PS00028
Domain-

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF180 ZNF429 ZNF397 ZNF223 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

1.84e-18679136333.30.160.60
DomainZnf_C2H2-like

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

3.29e-1879613635IPR015880
DomainZnf_C2H2

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

4.68e-1880513635IPR007087
DomainZnF_C2H2

ZNF438 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 MTF1 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

5.26e-1880813635SM00355
DomainKRAB

ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF223 ZNF416 ZNF786 ZNF585B ZNF10 ZNF182 ZNF610 ZNF33B RBAK ZNF624 ZNF91 ZNF782 ZNF439 ZNF614

1.38e-1535813623PS50805
DomainKRAB

ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF223 ZNF416 ZNF786 ZNF585B ZNF10 ZNF182 ZNF610 ZNF33B RBAK ZNF624 ZNF91 ZNF782 ZNF439 ZNF614

1.38e-1535813623PF01352
DomainKRAB

ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF223 ZNF416 ZNF786 ZNF585B ZNF10 ZNF182 ZNF610 ZNF33B RBAK ZNF624 ZNF91 ZNF782 ZNF439 ZNF614

2.66e-1536913623SM00349
DomainKRAB

ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF223 ZNF416 ZNF786 ZNF585B ZNF10 ZNF182 ZNF610 ZNF33B RBAK ZNF624 ZNF91 ZNF782 ZNF439 ZNF614

2.82e-1537013623IPR001909
Domainzf-C2H2_6

ZNF586 ZNF354A ZNF658 ZNF607 ZNF429 ZNF416 ZNF10 ZNF16 ZNF182 ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF572

9.62e-0931413615PF13912
DomainAAA

ABCC9 MCM4 DHX15 MDN1 NAV1 ASCC3 DNAH5 RAD17

1.05e-051441368SM00382
DomainAAA+_ATPase

ABCC9 MCM4 DHX15 MDN1 NAV1 ASCC3 DNAH5 RAD17

1.05e-051441368IPR003593
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

5.26e-0521362IPR022365
DomainClathrin-link

CLTCL1 CLTC

5.26e-0521362PF09268
Domain-

CLTCL1 CLTC

5.26e-05213622.130.10.110
DomainClathrin_heavy_chain

CLTCL1 CLTC

5.26e-0521362IPR016341
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

5.26e-0521362IPR001473
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

5.26e-0521362IPR016025
DomainClathrin_propel

CLTCL1 CLTC

5.26e-0521362PF01394
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

5.26e-0521362IPR015348
DomainClathrin_H-chain_linker

CLTCL1 CLTC

1.57e-0431362IPR012331
DomainCLH

CLTCL1 CLTC

1.57e-0431362SM00299
DomainARM-type_fold

GPRASP1 CLTCL1 NBEAL1 APOB HUWE1 DNAAF5 ANKAR CLTC ASPM

8.55e-043391369IPR016024
DomainClathrin

CLTCL1 CLTC

1.08e-0371362PF00637
DomainCHCR

CLTCL1 CLTC

1.08e-0371362PS50236
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

1.43e-0381362IPR000547
Pubmed

Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.

ZNF354A ZNF268 ZNF10 TRIM28 ZNF91

1.27e-109141523665872
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF585A ZNF429 ZNF585B ZNF610 ZNF624 ZNF91

4.83e-084914169630514
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF354A ZNF607 ZNF182 ZNF33B TRIM28 ZNF624 ZNF841 ZNF91 ZNF614

5.95e-08181141937372979
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

SLF1 L3MBTL2 TRAPPC8 NCLN GASK1B ZNF786 REXO2 CAMKV ARHGEF2 ASCC3 ADPGK WDR44 ZNF572 MYBPC1 EXOC4 RAD17

7.38e-087501411611230166
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

L3MBTL2 ITSN1 MCM4 HUWE1 EXOC8 TRIM28 CLTC NAV1 AP4M1 ARHGEF2 DNAH5

1.24e-073321411137433992
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FAM120B MYO1C L3MBTL2 GNE RPN1 RPS2 MCM4 HUWE1 DHX15 RLF PLCD3 PDE12 MDN1 TRIM28 CLTC ASPM ARHGEF2 ASCC3 CPSF3 EXOC4

6.00e-0713531412029467282
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

AMFR EMC1 RPN1 HUWE1 NCLN PTGFRN EXOC8 DNAAF5 PDE12 EPHA2 PCSK6 CLTC CERS1 ARHGEF2 ASCC3 EXOC4

1.52e-069421411631073040
Pubmed

Specific and ubiquitous expression of different Zn finger protein genes in the mouse.

ZNF585A ZNF585B ZNF624

2.26e-06714133143103
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MGAT4B CLTCL1 ZNF585A LPAR5 TBC1D25 HUWE1 NCLN PLCD3 IGF1R MDN1 ZNF827 TRIM28 ZNF335 NAV1 ARHGEF2 MAPKBP1 ZNF614

2.66e-0611051411735748872
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

NEB DHX15 MDN1 ZNF335 CLTC ASPM PLCH1 DNAH5

5.47e-06234141836243803
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF10 ZNF16 ZNF182 ZNF33B

7.48e-063114142288909
Pubmed

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.

MYO1C RPN1 TRIM28 EPHA2 CLTC ARHGEF2

9.06e-06118141627377895
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

KIF13B GPRASP1 ITSN1 HUWE1 FRY PTPN9 CNTNAP5 MDN1 AKAP9 CAMKV TRIM28 CSNK1A1 CLTC NAV1 ARHGEF2

9.25e-069631411528671696
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

RPN1 RPS2 MCM4 HUWE1 DHX15 DNAAF5 MDN1 TRIM28 CLTC ASCC3 CPSF3 EXOC4

1.22e-056381411233239621
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

AMFR EMC1 L3MBTL2 RPN1 HUWE1 NCLN EXOC8 DHX15 DNAAF5 TRIM28 CLTC EXOC4

1.63e-056571411236180527
Pubmed

Role of IGF-1R in ameliorating apoptosis of GNE deficient cells.

GNE IGF1R

1.63e-052141229743626
Pubmed

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells.

AMFR APOB

1.63e-052141212670940
Pubmed

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions.

ZNF10 TRIM28

1.63e-052141210653693
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

1.63e-05214128733129
Pubmed

Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.

ZNF585A ZNF585B

1.63e-052141237668106
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

1.63e-052141229097553
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

1.63e-052141220065094
Pubmed

A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion.

ZNF10 TRIM28

1.63e-052141216904636
Pubmed

Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.

ZNF10 TRIM28 ZNF91

1.81e-0513141319850934
Pubmed

Defining the membrane proteome of NK cells.

AMFR CLTCL1 MYO1C RPN1 RPS2 MCM4 HUWE1 NCLN ANKZF1 EXOC8 MDN1 CSNK1A1 CLTC ASCC3 ADPGK EXOC4

2.23e-0511681411619946888
Pubmed

Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.

ZNF10 ZNF182 ZNF33B

2.30e-051414132014798
Pubmed

The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.

MYO1C EXOC8 EXOC4

2.86e-0515141324056301
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

AMFR MAGEA12 ZNF658 RPN1 NCLN PTGFRN EXOC8 DHX15 RLF ZNF16 IGF1R TRIM28 RBAK CLTC ADPGK EXOC4

3.18e-0512031411629180619
Pubmed

The LIFEdb database in 2006.

L3MBTL2 NCLN GASK1B ZNF786 REXO2 ARHGEF2 ASCC3 WDR44 ZNF572 MYBPC1 EXOC4 RAD17

3.96e-057201411216381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

L3MBTL2 NCLN GASK1B ZNF786 REXO2 ARHGEF2 ASCC3 WDR44 ZNF572 MYBPC1 EXOC4 RAD17

4.07e-057221411215489336
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

EMC1 RPN1 ENPP3 HUWE1 NCLN PTGFRN DHX15 IGF1R TRIM28 CLTC ARHGEF2

4.35e-056131411122268729
Pubmed

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.

MYO1C RPN1 RPS2 DHX15 CLTC ARHGEF2

4.40e-05156141632850835
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

AMFR L3MBTL2 RPS2 HUWE1 NCLN DHX15 TRIM28 CLTC EXOC4

4.62e-05408141933766124
Pubmed

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.

ZNF841 ZNF614

4.88e-053141224280104
Pubmed

The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain.

ZNF10 TRIM28

4.88e-053141217512541
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

4.88e-053141219509056
Pubmed

SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.

EXOC8 EXOC4

4.88e-053141221658605
Pubmed

Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.

ZNF10 TRIM28

4.88e-05314129016654
Pubmed

Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes.

RYR2 NOS3

4.88e-053141218077344
Pubmed

Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain.

ZNF10 TRIM28

4.88e-053141210748030
Pubmed

The association between paired basic amino acid cleaving enzyme 4 gene haplotype and diastolic blood pressure.

IGF1R PCSK6

4.88e-053141215043778
Pubmed

Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents.

APOB NOS3

4.88e-053141220930716
Pubmed

GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway.

GPRASP1 IGF1R

4.88e-053141236042202
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

4.88e-053141222891263
Pubmed

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins.

ZNF354A TRIM28

4.88e-05314128986806
Pubmed

Molecular cloning and expression of two distinct human N-acetylgalactosamine 4-O-sulfotransferases that transfer sulfate to GalNAc beta 1-->4GlcNAc beta 1-->R in both N- and O-glycans.

CHST9 LHCGR

4.88e-053141211445554
Pubmed

The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.

ZNF10 TRIM28

4.88e-053141235162997
Pubmed

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

CLTCL1 CLTC

4.88e-053141215133132
Pubmed

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.

TRIM28 ZNF91

4.88e-053141225274305
Pubmed

Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

MYO1C RPN1 HUWE1 NCLN DNAAF5 CSNK1A1 EPHA2 ARHGEF2

5.51e-05323141824797263
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

MYO1C RPN1 RPS2 APOB HUWE1 DHX15 CLTC

6.53e-05244141728902428
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

AMFR CLTCL1 MYO1C RPN1 MCM4 HUWE1 EXOC8 MDN1 TRIM28 CLTC EXOC4

7.04e-056471411126618866
Pubmed

Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.

ZNF268 ZNF429 ZNF10

8.22e-052114137865130
Pubmed

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.

RPN1 RPS2 MCM4 HUWE1 DHX15 TRIM28

8.33e-05175141625756610
Pubmed

The NIZP1 KRAB and C2HR domains cross-talk for transcriptional regulation.

ZNF10 TRIM28

9.74e-054141220176155
Pubmed

ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.

ZNF10 TRIM28

9.74e-054141221170338
Pubmed

Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K-AKT-nNOS signaling.

RYR2 NOS3

9.74e-054141232580946
Pubmed

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

ZNF10 TRIM28

9.74e-05414128769649
Pubmed

DUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression.

ZNF10 TRIM28

9.74e-054141231856708
Pubmed

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

CLTCL1 CLTC

9.74e-054141211517213
Pubmed

DNA cloning using in vitro site-specific recombination.

L3MBTL2 NCLN GASK1B ZNF786 REXO2 ARHGEF2 ASCC3 WDR44 ZNF572 MYBPC1 EXOC4 RAD17

1.00e-047941411211076863
Pubmed

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.

L3MBTL2 MDN1 TRIM28 RBAK CPSF3

1.14e-04116141521549307
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EMC1 L3MBTL2 RPN1 TEX2 ITSN1 TRAPPC8 NCLN PDE12 MDN1 AKAP9 EPHA2 CLTC ASPM COL14A1 ASCC3 PLCH1 EXOC4

1.15e-0414871411733957083
Pubmed

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.

EMC1 RPN1 APOB

1.24e-0424141325009997
Pubmed

Identification of host proteins required for HIV infection through a functional genomic screen.

ZNF354A HUWE1 TRAPPC8 USP26 ZNF182 ALKBH8 MDN1

1.28e-04272141718187620
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

ZNF180 ITSN1 AKAP9 NAV1 EXOC4

1.34e-04120141531413325
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

KIF13B EMC1 RPS2 MCM4 HUWE1 PDE12 TRIM28 CLTC ASCC3 DNAH5 EXOC4

1.48e-047041411129955894
Pubmed

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.

EMC1 NCLN DNAAF5 PCSK6 COL14A1 CERS1 CPSF3

1.60e-04282141735007762
Pubmed

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.

HUWE1 TRIM28

1.62e-045141233004795
Pubmed

Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.

CLTCL1 CLTC

1.62e-045141210436022
Pubmed

TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.

ZNF10 TRIM28

1.62e-045141210022127
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

AMFR NEB RYR2

1.78e-0427141318468998
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

DHX15 MDN1 TRIM28 ARHGEF2 ASCC3

1.88e-04129141523022380
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KIF13B EMC1 TEX2 CDK14 IGF1R MDN1 AKAP9 CSNK1A1 NAV1 ARHGEF2 PLCH1 EXOC4

2.12e-048611411236931259
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

EMC1 MYO1C RPN1 RPS2 MCM4 APOB HUWE1 NCLN DHX15 PDE12 MDN1 TRIM28 CLTC DNAH5 CPSF3 MYBPC1

2.26e-0414251411630948266
Pubmed

Subunit structure of the mammalian exocyst complex.

EXOC8 EXOC4

2.42e-04614129405631
Pubmed

OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation.

AMFR RPN1

2.42e-046141223606741
Pubmed

CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.

CSNK1A1 CPSF3

2.42e-046141218305108
Pubmed

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.

IGF1R CLTC

2.42e-046141218286479
Pubmed

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

ITSN1 ARHGEF2

2.42e-046141212006984
Pubmed

Arl13b and the exocyst interact synergistically in ciliogenesis.

EXOC8 EXOC4

2.42e-046141226582389
Pubmed

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

RYR2 PLCH1

2.42e-046141223540699
Pubmed

Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.

APOB NOS3

2.42e-046141216776623
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

GPRASP1 ZNF586 CLTCL1 GCNT3 MYO1C GNE ZNF177 ZNF180 NEB CDK14 ZFX MDN1 SERTAD4 MYBPC1 CA6

2.54e-0412931411515342556
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

AMFR EMC1 CLTCL1 MYO1C RPN1 HUWE1 NCLN PTGFRN DHX15 DNAAF5 MDN1 TRIM28 CLTC ARHGEF2 ASCC3 EXOC4

2.54e-0414401411630833792
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KIF13B CLTCL1 MYO1C ZNF658 RPN1 ITSN1 APOB NEB RYR2 CHRNB3 MDN1 CLTC ASPM ARHGEF2 PLCH1 MYBPC1

2.58e-0414421411635575683
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

RPN1 RPS2 MCM4 APOB TECTA NEB DHX15 TRIM28 CLTC

2.58e-04513141925798074
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

HUWE1 MDN1 AKAP9 CSNK1A1

2.65e-0476141427542412
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ATP13A4 POT1 TBC1D25 NCLN NEB RYR2 TBC1D32 PTPN9 MDN1 ARHGEF2

2.89e-046381411031182584
Pubmed

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.

RPN1 RPS2 HUWE1 DHX15 TRIM28 CLTC

2.95e-04221141629991511
Pubmed

Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

L3MBTL2 GASK1B ZNF786 REXO2 CAMKV ASCC3 ZNF572 MYBPC1 EXOC4

2.98e-04523141911256614
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

MYO1C RPN1 NCLN DHX15 CLTC

3.12e-04144141535681168
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MYO1C ITSN1 MCM4 HUWE1 ZFX MDN1 TRIM28 ZNF335 CLTC ARHGEF2 WDR44

3.32e-047741411115302935
Pubmed

The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration.

ZNF429 TRIM28

3.38e-047141222801370
Pubmed

A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development.

RLF TRIM28

3.38e-047141219099580
Pubmed

[Population study of the Udmurt population: analysis of ten polymorphic DNA loci of the nuclear genome].

APOB NOS3

3.38e-047141217633563
Pubmed

A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.

CLTCL1 CLTC

3.38e-047141219478182
Pubmed

Global/temporal gene expression in diaphragm and hindlimb muscles of dystrophin-deficient (mdx) mice.

NEB TBC1D32

3.38e-047141212176734
Pubmed

Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.

MAGEA2 MAGEA12

3.38e-047141217634428
Pubmed

The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.

TRIM28 CLTC

3.38e-047141221382013
InteractionTRIM28 interactions

MAGEA2 KIF13B AMFR EMC1 ZNF354A L3MBTL2 ZNF658 ZNF607 ZNF268 RPS2 MCM4 ZNF223 HUWE1 ZNF416 ZNF585B DHX15 ZNF10 ZNF182 PDE12 ZNF33B TRIM28 RBAK CLTC ZNF624 ZNF841 ZNF91 ASCC3 DNAH5 ZNF614 EXOC4

4.53e-08147413730int:TRIM28
InteractionZNF33B interactions

MAGEA12 ZNF33B TRIM28

1.05e-0571373int:ZNF33B
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF438 ZNF717 ZNF586 ZNF585A ZNF354A ZNF658 ZNF607 ZNF268 ZNF177 ZNF180 ZNF429 ZNF397 ZNF223 ANKZF1 ZNF623 ZNF416 ZNF786 ZFX ZNF585B RLF ZNF10 ZNF16 ZNF182 ZNF610 ZNF33B ZNF827 ZNF335 RBAK ZNF624 ZNF841 ZNF91 ZNF782 ZNF439 ZNF614 ZNF572

1.23e-237181033528
GeneFamilyExocyst complex

EXOC8 EXOC4

1.13e-03910321055
Drugvinylene

ZNF354A RPS2 ENPP3 ZNF177 ZNF180 ZFX TRIM28 ZNF335 RBAK ZNF91

3.12e-0624514110CID000006326
DiseaseTachycardia, Ventricular

ABCC9 RYR2 NOS3

1.37e-05111313C0042514
Diseaseresponse to bronchodilator, response to corticosteroid

ZNF841 ZNF614

1.94e-0451312GO_0031960, GO_0097366
DiseaseDevelopmental delay (disorder)

IGF1R ALKBH8 ZNF335

5.95e-04371313C0424605
DiseaseAtrial Fibrillation

MYO1C RPS2 ABCC9 IGF1R NOS3

7.56e-041601315C0004238
Diseasephosphatidylethanolamine measurement

GCNT3 ABCC9 APOB STRADA NAV1

1.07e-031731315EFO_0010228
Diseasecardiomyopathy (biomarker_via_orthology)

IGF1R NOS3

1.48e-03131312DOID:0050700 (biomarker_via_orthology)
Diseasesalicylurate measurement

B3GALT1 RYR2

1.48e-03131312EFO_0010532
DiseaseAutosomal recessive primary microcephaly

ZNF335 ASPM

1.98e-03151312cv:C3711387
Diseaseamenorrhea, response to antineoplastic agent

APOB DERA

1.98e-03151312EFO_0010269, GO_0097327
Diseaseovarian cancer (is_implicated_in)

POT1 APOB NOS3

2.00e-03561313DOID:2394 (is_implicated_in)
Diseasesickle cell anemia (is_implicated_in)

APOB NOS3

2.25e-03161312DOID:10923 (is_implicated_in)
Diseasethyroid volume

IGF1R DNAH5

2.25e-03161312EFO_0004865
DiseaseLipidemias

APOB NOS3

2.55e-03171312C1706412
DiseaseHyperlipidemia

APOB NOS3

2.55e-03171312C0020473
DiseaseFetal Growth Retardation

IGF1R NOS3

3.53e-03201312C0015934
DiseaseTNF-related apoptosis-inducing ligand measurement

CHST9 TRAPPC8 PCSK6

4.08e-03721313EFO_0008300
Diseaseblood pressure

CNTNAP5 EXOC4

4.26e-03221312EFO_0004325

Protein segments in the cluster

PeptideGeneStartEntry
DHTYRLISVVSHLGK

USP26

821

Q9BXU7
RDHSIYTQLLEITLH

ACCSL

21

Q4AC99
HIRKGSIVVVDHLSY

BHLHB9

516

Q6PI77
YISRHVKKEHFISQV

CHRNB3

401

Q05901
HISETETLKREHYVA

AKAP9

2846

Q99996
LTRIHFHTLVYHILA

ADPGK

376

Q9BRR6
VHLISRVTFHYKRSS

ADAM23

386

O75077
LIIESTYGTHIHEKR

CPSF3

201

Q9UKF6
HAHYSRTTVLRLLET

TBC1D32

361

Q96NH3
ECIIKHDHIVSTIYS

HTR1F

171

P30939
KHTLLRHEGIETVSY

ALKBH8

26

Q96BT7
VYDLREQSVKLHHLV

ATP13A4

241

Q4VNC1
YELIQTELHHVRTLK

ARHGEF2

241

Q92974
IYKTSLHTRLLHLED

B3GALT1

251

Q9Y5Z6
LVLVTHKLQYLTHAD

ABCC9

866

O60706
HTKETLTLVFEYVHT

CDK14

201

O94921
VAHLERTGHYLTVKD

DHX15

701

O43143
IRHVIEIHIVHYNSK

CA6

131

P23280
VHLESTIAHEIYQKI

ASPM

351

Q8IZT6
RKHYLHLRATVVSIQ

ASPM

2641

Q8IZT6
FIHIRHSGLYLVVTT

AP4M1

56

O00189
LLSVVYISHRAHINV

NBEAL1

1221

Q6ZS30
SHTLHEVLRKYVRIG

RAD17

236

O75943
HYKKTTLEIHNTEER

PTPN9

441

P43378
LSTLEHHLSRYLKDV

NCLN

476

Q969V3
IHLSVLTFHTEVLKY

ANKAR

676

Q7Z5J8
SNVKSVYKTHIDVIH

MCM4

406

P33991
LVQEIHHYVTSIAKA

MDN1

3326

Q9NU22
HTITYAIHLDQKLRL

LHCGR

466

P22888
RALIETSYVKVLHHT

MAGEA2

276

P43356
RALVETSYVKVLHHL

MAGEA12

276

P43365
THRLHLVVYSLVLAA

LPAR5

21

Q9H1C0
VRREVHSYLTDTLHS

MGAT4B

151

Q9UQ53
ATVKRVVHRLLSIHF

L3MBTL2

556

Q969R5
CSDLRSQIHLHKYVV

IL17RB

431

Q9NRM6
IEVVTGYVKIRHSHA

IGF1R

381

P08069
GYVKIRHSHALVSLS

IGF1R

386

P08069
VVYLEHVVVRTSISH

PCSK6

536

P29122
SYVHIAHAVLRVKST

OR2Y1

216

Q8NGV0
NSYVIVLVTVKHHSS

OR4K2

216

Q8NGD2
HRHLYTKKVTEDALI

PDE12

281

Q6L8Q7
LHTEETYVKRLHLLD

FGD3

166

Q5JSP0
HSYKEIIIEATKHRN

EXOC8

556

Q8IYI6
KIEKRTTSNTLHYIH

HUWE1

211

Q7Z6Z7
VLHSYQLAKVTIVDH

NOS3

406

P29474
HLHYRIIDVSTVKEL

REXO2

161

Q9Y3B8
SIYKDVTSVHLDHLR

PDP2

196

Q9P2J9
IEHRAKILITYINAH

GASK1B

496

Q6UWH4
VLIDELHRHLYIKST

EXOC4

191

Q96A65
LHRHLYIKSTSRVVQ

EXOC4

196

Q96A65
TELEYIHALTLLHRS

EXOC4

921

Q96A65
SLDEHYHIRVNLVKT

APOB

2211

P04114
YHIRVNLVKTIHDLH

APOB

2216

P04114
RSHLNEIKVYITFHS

CPA3

291

P15088
EAVAYLHSLKIVHRN

CAMKV

131

Q8NCB2
ILSGVLASHYIHIVK

GNE

666

Q9Y223
LASHYIHIVKDVIRQ

GNE

671

Q9Y223
EVVTHKTFHRYTVRA

ANKZF1

226

Q9H8Y5
LQRVLHKLTTLHVYE

ANKZF1

336

Q9H8Y5
DYFHSVLLIKHATER

ENPP3

726

O14638
VHRHATAYRVVIESL

COL14A1

941

Q05707
SHHNIIRLEGVISKY

EPHA2

671

P29317
HISHIDRVYTLRAES

ITSN1

1541

Q15811
KYHFEVVRDTLHLTN

GCNT3

266

O95395
SIHRHTVVKLAHTYQ

CENPM

111

Q9NSP4
LHHVVTLILIVSSYA

CERS1

181

P27544
QFTRTHHVVRKTTLY

MAPKBP1

606

O60336
EKRKLSVLHIHGVYT

FAM118B

196

Q9BPY3
RYIAVLKKTTLALHH

EMC1

141

Q8N766
SYQHSDLSKIEIHRV

FRY

2301

Q5TBA9
RETEAVIHKHRSATY

DNAAF5

826

Q86Y56
VIHKHRSATYCEQLL

DNAAF5

831

Q86Y56
STLLSDIERQIYHHV

DERA

291

Q9Y315
HASLIDSLLHTVYRL

RYR2

2541

Q92736
SHRIIAVHYVLEESS

RYR2

4551

Q92736
VRYHLNKEETHVFTI

CNTNAP5

1076

Q8WYK1
TERVKYETLITIHVH

DNAH5

1881

Q8TE73
ILKVARTHHVQAESY

FAM120B

576

Q96EK7
VTYLHALLHTVLIAQ

OR1C1

151

Q15619
KLVYHNETTVHHILV

MOXD2P

231

A6NHM9
IHGYSISHVKRVLDA

NAV1

1486

Q8NEY1
IRHLTTTTDYHTLVA

GPRASP1

1261

Q5JY77
VALSHVDARSYHLLV

PTGFRN

346

Q9P2B2
RSHAVFKITLTHTLY

KIF13B

221

Q9NQT8
YVHRSVKASHILISV

STRADA

191

Q7RTN6
LRALHDLLTTYAVTH

TBC1D25

311

Q3MII6
HLVYVLHLISKNSEV

TAGAP

211

Q8N103
FLTSYSLRIHVRVHT

MTF1

181

Q14872
ISRIEYVHTKNFIHR

CSNK1A1

121

P48729
LVYDNHVHVARSLKV

POT1

221

Q9NUX5
KISVIVETVYTHVLH

RPN1

126

P04843
DLHSVGTSRLLYHIT

FAM13C

216

Q8NE31
HKTISIFEERAHILY

SERTAD4

96

Q9NUC0
VTVRTAHVILRYVIH

AMFR

226

Q9UKV5
IITTHDKLSHYLTLL

ASCC3

866

Q8N3C0
TDLYDIKRAVVHTHL

CLTC

631

Q00610
TDLYDIKRAVVHTHL

CLTCL1

631

P53675
HTVSRIYVEDKHKIL

CHST9

201

Q7L1S5
SYVLIEHQRTHTGEK

ZNF572

256

Q7Z3I7
LSYLARHQIIHSTEK

ZNF610

356

Q8N9Z0
VIHRAYKHTVLVNSE

TECTA

1171

O75443
VIHKHDLSETNVYLI

TDP1

341

Q9NUW8
TKSYLIVHQRTHTGE

ZNF624

651

Q9P2J8
FSRKSSLIIHLRVHT

ZNF586

326

Q9NXT0
IAYLHSKSIVHRDLK

TSSK4

136

Q6SA08
EKSTVIIHYRTHTGE

ZNF182

301

P17025
SSYLLIHQRVHTGEK

ZNF223

356

Q9UK11
FYHKSVLTRHQIIHT

ZNF33B

506

Q06732
SKSYLIIHTRTHTGE

ZNF268

511

Q14587
LIVHKRTHTGEKTYE

ZNF177

411

Q13360
KLESSIVRHYKRTHQ

RLF

1561

Q13129
RDLYVTATHSVHEEK

SAGE1

666

Q9NXZ1
YHGHTLTSKILFRDV

PLCD3

396

Q8N3E9
VSYLTIHYRSHLEEK

RBAK

441

Q9NYW8
ASYLVIHERIHTGEK

ZNF607

461

Q96SK3
TEHLKYHTQIHVRST

WDR44

721

Q5JSH3
ALTVHQRIHTGEKSY

ZNF585B

396

Q52M93
AKHHITIAEIYETEL

NAPB

121

Q9H115
VEHEKIKSTLRRHIY

SLF1

326

Q9BQI6
VVHHGYTLTSKILFR

PLCH1

356

Q4KWH8
ALTVHQRIHTGEKSY

ZNF585A

396

Q6P3V2
TFVYKAALIVHQRIH

ZNF658

806

Q5TYW1
SYKSSLIIHQRIHTG

ZNF717

321

Q9BY31
YDKTVLTIHQRTHTG

ZNF717

796

Q9BY31
TLSRHLSLHTEERKY

ZNF827

831

Q17R98
YTQRSSLTKHLVIHT

ZNF841

546

Q6ZN19
LVTHQRTHTGDKLYT

ZNF10

336

P21506
SYVLVVHQRTHTGEK

ZNF180

421

Q9UJW8
LIRHQATHTEEKLYE

ZNF180

676

Q9UJW8
FIYKSKLAEHIRVHT

ZNF786

741

Q8N393
TLTEHKRIHTREKTY

ZNF91

896

Q05481
SYTLVEHQKIHTGLR

ZNF416

506

Q9BWM5
SSYLIIHQRIHTGEK

ZNF397

381

Q8NF99
SIYHTTRLLEKKLHR

ZSWIM3

306

Q96MP5
SDLKRHIISVHTKDY

ZFX

646

P17010
YSSTLTRHKRIHTEE

ZNF429

436

Q86V71
SYSSVLRKHQIIHTG

ZNF16

471

P17020
HHVILRTIGKEAFSY

TRAPPC8

1261

Q9Y2L5
YKSILIVHQRTHTGE

ZNF782

461

Q6ZMW2
LSTSLYKHLRTHTVE

ZNF354A

281

O60765
LIVHQRSHTGEKSYI

ZNF614

386

Q8N883
SSLIRHYQIHTEVKQ

ZNF623

276

O75123
LSSYLIRHQKIHTGE

ZNF623

386

O75123
TYHATLTHSVFVRLE

TEX2

561

Q8IWB9
YQEFTDHLVKTHTRV

RPS2

266

P15880
TSVYRKDVIRHAAVH

ZNF335

531

Q9H4Z2
VYFGHLKEVHRVVIS

ZNF438

581

Q7Z4V0
HQRVKYTKDHTVRST

TRIM28

181

Q13263
LSLYLIHERTHTGEK

ZNF439

226

Q8NDP4
KTIISAHSVLRHNYR

TTLL13

341

A6NNM8
TFVYKAALIVHQRIH

ZNF658B

566

Q4V348
HILSYLLEKSRVVHQ

MYO1C

216

O00159
VIEHYHRTSATITEL

MYBPC1

981

Q00872
VRETQRHISTVKYHE

NEB

6426

P20929