Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM1 GRM4 GRM5 GRM7

1.69e-0791234GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM1 GRM4 GRM5 GRM7

1.69e-0791234GO:0001640
GeneOntologyMolecularFunctionglutamate receptor activity

GRM1 GRM4 GRM5 GRM7

2.16e-05271234GO:0008066
GeneOntologyMolecularFunctionPLC activating G protein-coupled glutamate receptor activity

GRM1 GRM5

3.76e-0521232GO:0001639
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7

1.12e-0431232GO:0008389
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETMAR NSD1 EZH1 KMT2A

1.54e-04441234GO:0140938
GeneOntologyMolecularFunctionphosphatidylinositol-4-phosphate phosphatase activity

INPP5F FIG4

2.24e-0441232GO:0043812
GeneOntologyMolecularFunctionhistone H3K36 dimethyltransferase activity

SETMAR NSD1

2.24e-0441232GO:0140954
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

GRM1 GRM5

2.24e-0441232GO:0099583
GeneOntologyMolecularFunctiongroup III metabotropic glutamate receptor activity

GRM4 GRM7

2.24e-0441232GO:0001642
GeneOntologyMolecularFunctionG protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

GRM1 GRM5

3.72e-0451232GO:0099530
GeneOntologyMolecularFunctionhistone modifying activity

KDM3A SETMAR NSD1 PCGF3 EZH1 BAZ1A KMT2A

5.48e-042291237GO:0140993
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETMAR NSD1 EZH1 KMT2A

8.24e-04681234GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETMAR NSD1 EZH1 KMT2A

8.70e-04691234GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETMAR NSD1 EZH1 KMT2A

9.69e-04711234GO:0042054
GeneOntologyMolecularFunctionspectrin binding

GBP1 GBP2 SPTBN4

1.19e-03341233GO:0030507
GeneOntologyMolecularFunctionprotein kinase activity

RIPK3 NEK10 MATK ROR2 PAK6 CDC42BPB TNNI3K NEK1 NRBP2 FER TSSK1B

1.21e-0360012311GO:0004672
GeneOntologyMolecularFunctionmetallopeptidase activity

CPM ADAMTS7 LTA4H KEL ADAM2 MMP14

1.51e-032001236GO:0008237
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 4-phosphatase activity

INPP5F FIG4

1.64e-03101232GO:0034596
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

GRM1 GRM4 GRM5 GRM7

1.39e-0791214GO:0007196
GeneOntologyBiologicalProcessG protein-coupled glutamate receptor signaling pathway

GRM1 GRM4 GRM5 GRM7

1.94e-06161214GO:0007216
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRM1 GRM4 GRM5 GRM7 TIAM1

2.48e-05591215GO:0007215
GeneOntologyBiologicalProcesslearning

PAK6 IDUA GRM4 GRM5 GRM7 KMT2A SORCS3 ADAM2

3.63e-052121218GO:0007612
GeneOntologyCellularComponentperoxisome

NUDT19 SZT2 VWA8 ISOC1 AGPS ABCD2

3.98e-041621236GO:0005777
GeneOntologyCellularComponentmicrobody

NUDT19 SZT2 VWA8 ISOC1 AGPS ABCD2

3.98e-041621236GO:0042579
GeneOntologyCellularComponenthost intracellular region

GBP1 GBP2

5.07e-0461232GO:0043656
GeneOntologyCellularComponenthost cell cytoplasm

GBP1 GBP2

5.07e-0461232GO:0030430
GeneOntologyCellularComponenthost cell part

GBP1 GBP2

5.07e-0461232GO:0033643
GeneOntologyCellularComponenthost intracellular part

GBP1 GBP2

5.07e-0461232GO:0033646
GeneOntologyCellularComponenthost cell cytoplasm part

GBP1 GBP2

5.07e-0461232GO:0033655
GeneOntologyCellularComponentsymbiont-containing vacuole

GBP1 GBP2

5.07e-0461232GO:0020003
GeneOntologyCellularComponentsymbiont-containing vacuole membrane

GBP1 GBP2

5.07e-0461232GO:0020005
GeneOntologyCellularComponentsymbiont cell surface

GBP1 GBP2

9.40e-0481232GO:0106139
GeneOntologyCellularComponentcentriolar satellite

SPAG9 CCDC13 NEK1 G6PD WDR62

9.66e-041281235GO:0034451
GeneOntologyCellularComponentlysosome

SZT2 HYAL1 PSMD1 SPG11 SPAG9 IDUA ANKRD27 KLHL22 EPG5 HGS LAMP3 SLC35F6 VTI1B

9.89e-0481112313GO:0005764
GeneOntologyCellularComponentlytic vacuole

SZT2 HYAL1 PSMD1 SPG11 SPAG9 IDUA ANKRD27 KLHL22 EPG5 HGS LAMP3 SLC35F6 VTI1B

9.89e-0481112313GO:0000323
GeneOntologyCellularComponentother organism part

GBP1 GBP2

1.20e-0391232GO:0044217
GeneOntologyCellularComponentadherens junction

AHI1 SPTBN4 FER CTNNA2 MPP7 CDH18

1.61e-032121236GO:0005912
DomainGPCR_3_mtglu_rcpt

GRM1 GRM4 GRM5 GRM7

1.08e-0781194IPR000162
DomainNCD3G

GRM1 GRM4 GRM5 GRM7

1.07e-06131194PF07562
DomainGPCR_3_9-Cys_dom

GRM1 GRM4 GRM5 GRM7

1.07e-06131194IPR011500
DomainGPCR_3_CS

GRM1 GRM4 GRM5 GRM7

1.49e-06141194IPR017979
DomainGPCR_3

GRM1 GRM4 GRM5 GRM7

8.62e-06211194IPR000337
Domain7tm_3

GRM1 GRM4 GRM5 GRM7

1.05e-05221194PF00003
DomainG_PROTEIN_RECEP_F3_2

GRM1 GRM4 GRM5 GRM7

1.05e-05221194PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM1 GRM4 GRM5 GRM7

1.05e-05221194PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM1 GRM4 GRM5 GRM7

1.05e-05221194PS00979
DomainG_PROTEIN_RECEP_F3_4

GRM1 GRM4 GRM5 GRM7

1.05e-05221194PS50259
DomainGPCR_3_C

GRM1 GRM4 GRM5 GRM7

1.05e-05221194IPR017978
DomainGluR_Homer-bdg

GRM1 GRM5

4.03e-0521192PF10606
DomainMetabotropic_Glu_rcpt_Homer-bd

GRM1 GRM5

4.03e-0521192IPR019588
DomainGPCR_3_mtglu_rcpt_1

GRM1 GRM5

4.03e-0521192IPR001256
DomainGluR_Homer-bdg

GRM1 GRM5

4.03e-0521192SM01229
DomainGPCR_3_mtglu_rcpt_5

GRM1 GRM5

4.03e-0521192IPR000202
DomainANF_lig-bd_rcpt

GRM1 GRM4 GRM5 GRM7

8.79e-05371194IPR001828
DomainANF_receptor

GRM1 GRM4 GRM5 GRM7

8.79e-05371194PF01094
DomainPeripla_BP_I

GRM1 GRM4 GRM5 GRM7

1.08e-04391194IPR028082
DomainPC_rep

PSMD1 ANAPC1

1.20e-0431192PF01851
DomainProteasome/cyclosome_rpt

PSMD1 ANAPC1

1.20e-0431192IPR002015
DomainSET

SETMAR NSD1 EZH1 KMT2A

1.32e-04411194PF00856
DomainPost-SET_dom

SETMAR NSD1 KMT2A

1.33e-04161193IPR003616
DomainPostSET

SETMAR NSD1 KMT2A

1.33e-04161193SM00508
DomainPOST_SET

SETMAR NSD1 KMT2A

1.33e-04161193PS50868
DomainKinase-like_dom

RIPK3 NEK10 MATK ROR2 PAK6 ARHGAP35 CDC42BPB TNNI3K NEK1 NRBP2 FER TSSK1B

1.79e-0454211912IPR011009
DomainSET

SETMAR NSD1 EZH1 KMT2A

2.08e-04461194SM00317
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7

2.40e-0441192IPR008067
DomainSET_dom

SETMAR NSD1 EZH1 KMT2A

2.88e-04501194IPR001214
DomainSET

SETMAR NSD1 EZH1 KMT2A

2.88e-04501194PS50280
DomainProt_kinase_dom

RIPK3 NEK10 MATK ROR2 PAK6 CDC42BPB TNNI3K NEK1 NRBP2 FER TSSK1B

2.93e-0448911911IPR000719
DomainPROTEIN_KINASE_DOM

RIPK3 NEK10 MATK ROR2 PAK6 CDC42BPB TNNI3K NEK1 NRBP2 FER TSSK1B

3.14e-0449311911PS50011
DomainSortilin_C

SORCS1 SORCS3

3.98e-0451192PF15901
DomainSortilin-Vps10

SORCS1 SORCS3

3.98e-0451192PF15902
DomainVPS10

SORCS1 SORCS3

3.98e-0451192IPR006581
DomainSyja_N

INPP5F FIG4

3.98e-0451192PF02383
DomainSortilin_N

SORCS1 SORCS3

3.98e-0451192IPR031778
DomainSortilin_C

SORCS1 SORCS3

3.98e-0451192IPR031777
DomainVPS10

SORCS1 SORCS3

3.98e-0451192SM00602
DomainSAC

INPP5F FIG4

3.98e-0451192PS50275
DomainSAC_dom

INPP5F FIG4

3.98e-0451192IPR002013
DomainPROTEIN_KINASE_ATP

RIPK3 NEK10 MATK ROR2 PAK6 CDC42BPB TNNI3K NEK1 FER TSSK1B

7.13e-0445911910PS00107
DomainProtein_kinase_ATP_BS

RIPK3 NEK10 MATK PAK6 CDC42BPB TNNI3K NEK1 FER TSSK1B

7.22e-043791199IPR017441
DomainPKD

SORCS1 SORCS3

8.28e-0471192PF00801
DomainSialidases

SORCS1 SORCS3

1.41e-0391192IPR011040
DomainGBP_C

GBP1 GBP2

1.75e-03101192PF02841
DomainG_GB1_RHD3_dom

GBP1 GBP2

2.13e-03111192IPR030386
DomainGuanylate-bd_N

GBP1 GBP2

2.13e-03111192IPR015894
DomainPKD

SORCS1 SORCS3

2.13e-03111192PS50093
DomainPKD_dom

SORCS1 SORCS3

2.13e-03111192IPR000601
DomainGuanylate-bd_C

GBP1 GBP2

2.13e-03111192IPR003191
DomainGBP

GBP1 GBP2

2.13e-03111192PF02263
Domain-

SORCS1 SORCS3

2.13e-031111922.60.40.670
DomainG_GB1_RHD3

GBP1 GBP2

2.13e-03111192PS51715
DomainZnf_FYVE_PHD

KDM3A NSD1 BAZ1A HGS KMT2A

2.51e-031471195IPR011011
DomainPROTEIN_KINASE_TYR

NEK10 MATK ROR2 FER

3.44e-03971194PS00109
DomainTyr_kinase_AS

NEK10 MATK ROR2 FER

3.44e-03971194IPR008266
DomainZINC_PROTEASE

ADAMTS7 LTA4H KEL MMP14

3.57e-03981194PS00142
DomainIg_E-set

A2M FLNC PKHD1L1 SNRNP200

4.41e-031041194IPR014756
DomainPBD

PAK6 CDC42BPB

4.56e-03161192SM00285
DomainPBD

PAK6 CDC42BPB

5.14e-03171192PF00786
DomainHATPase_c

PMS1 MORC4

5.76e-03181192SM00387
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM1 GRM4 GRM5 GRM7

2.83e-0615984M39442
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM1 GRM4 GRM5 GRM7

2.83e-0615984MM15845
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GRM1 GRM4 GRM5 GRM7

1.22e-0437984MM15067
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

GRM1 GRM4 GRM5 GRM7

1.50e-0439984M793
Pubmed

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.

GRM1 GRM4 GRM5 GRM7

5.34e-09712449920659
Pubmed

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

GRM1 GRM4 GRM5 GRM7

3.18e-081012449069281
Pubmed

The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.

GRM1 GRM5 GRM7

4.42e-083124316024054
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

MATK ROR2 PAK6 PCGF3 KLHL22 TNNI3K SF3B3 DTX4 FER TSSK1B

9.62e-073721241022939624
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

FLNC RARS1 COQ6 RPS15 ISOC1 PSMD1 PSMD3 EPG5 ERLIN2 SF3B3 KMT2A LTA4H G6PD SNRNP200

1.21e-068071241430575818
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRM1 GRM4 GRM5 GRM7

1.55e-0624124435746896
Pubmed

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

MATK RPS15 PAK6 NEK1

1.84e-0625124424947832
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

HECTD4 KCNAB2 NSD1 GRM1 GRM4 GRM5 CDC42BPB SPTBN4 CCDC13 FARSA ANAPC1 KIF5A CTNNA2 NEURL4 NIPBL

1.86e-069631241528671696
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

A2M FLNC PLOD3 RPS15 PSMD1 PSMD3 SPAG9 TRMT10C ERLIN2 TTC17 KIF5A MMP14 G6PD SNRNP200 MPP7

2.14e-069741241528675297
Pubmed

The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.

GRM1 GRM4 GRM7

5.21e-0610124317156446
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

PMS1 PLOD3 PDPR RPS15 PSMD1 PSMD3 SPAG9 CDC42BPB TRMT10C TIAM1 HGS RELL1 G6PD NEURL4 MPP7

5.25e-0610491241527880917
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NUDT19 PMS1 PLOD3 PDPR VWA8 ROR2 SPG11 CDC42BPB TRMT10C SF3B3 TIAM1 HGS TTC17 RELL1 SNRNP200 NEURL4 WDR62 MPP7

5.71e-0614871241833957083
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM3A NSD1 EZH1 KMT2A

5.81e-0633124426864203
Pubmed

WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.

RFX2 TDRD6 MAPKBP1 WDR62

1.03e-0538124434059773
Pubmed

Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.

PDE1A RARS1 ARHGAP35

1.23e-0513124321844884
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

USP18 KDM3A NSD1 CPM INPP5F PCGF3 LRP1B CDC42BPB NEK1 KMT2A ADAM2 MMP14

1.25e-057301241234857952
Pubmed

Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn.

GRM1 GRM5

1.26e-052124218554818
Pubmed

Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.

GRM1 GRM5

1.26e-052124222028929
Pubmed

Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP.

GRM1 GRM5

1.26e-05212429185557
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

1.26e-052124212325023
Pubmed

Dimerization and its role in GMP formation by human guanylate binding proteins.

GBP1 GBP2

1.26e-052124220923658
Pubmed

Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex.

GRM1 GRM5

1.26e-052124227392515
Pubmed

SORCS1 and SORCS3 control energy balance and orexigenic peptide production.

SORCS1 SORCS3

1.26e-052124229440124
Pubmed

Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia.

GRM4 GRM7

1.26e-052124219351574
Pubmed

Genetic inactivation of mGlu5 receptor improves motor coordination in the Grm1crv4 mouse model of SCAR13 ataxia.

GRM1 GRM5

1.26e-052124228982591
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

1.26e-052124216636685
Pubmed

Neutrophil-derived glutamate regulates vascular endothelial barrier function.

GRM1 GRM4

1.26e-052124211847215
Pubmed

mGluR₁,5 activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: implication for anxiety-like behavior in DBA/2 mice.

GRM1 GRM5

1.26e-052124222681774
Pubmed

Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase.

INPP5F FIG4

1.26e-052124211274189
Pubmed

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

GRM4 GRM5

1.26e-052124225747602
Pubmed

Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus.

GRM1 GRM5

1.26e-052124218035501
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

1.26e-05212422322567
Pubmed

Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice.

GRM1 GRM5

1.26e-052124212623213
Pubmed

Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.

GRM1 GRM5

1.26e-052124215184389
Pubmed

mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment.

GRM1 GRM5

1.26e-052124223280324
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

1.26e-05212427864805
Pubmed

Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.

GBP1 GBP2

1.26e-052124236460216
Pubmed

Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition.

GRM1 GRM5

1.26e-052124217093122
Pubmed

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

GRM1 GRM5

1.26e-052124211591458
Pubmed

Proteasome 26S subunit, non-ATPases 1 (PSMD1) and 3 (PSMD3), play an oncogenic role in chronic myeloid leukemia by stabilizing nuclear factor-kappa B.

PSMD1 PSMD3

1.26e-052124233712704
Pubmed

A negative feedback loop between JNK-associated leucine zipper protein and TGF-β1 regulates kidney fibrosis.

SPAG9 CDH16

1.26e-052124232504044
Pubmed

Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons.

GRM4 GRM5

1.26e-052124218174899
Pubmed

Identification and characterization of SorCS, a third member of a novel receptor family.

SORCS1 SORCS3

1.26e-052124210600506
Pubmed

Symmetric signal transduction and negative allosteric modulation of heterodimeric mGlu1/5 receptors.

GRM1 GRM5

1.26e-052124233279506
Pubmed

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.

GRM1 GRM4

1.26e-052124217446080
Pubmed

Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.

GBP1 GBP2

1.26e-052124223086406
Pubmed

In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

GRM1 GRM5

1.26e-052124231102766
Pubmed

26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy.

PSMD1 PSMD3

1.26e-052124234572038
Pubmed

Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine.

GBP1 GBP2

1.26e-052124220483731
Pubmed

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning.

GRM1 GRM5

1.26e-052124235805089
Pubmed

JLP/Foxk1/N-cadherin axis fosters a partial epithelial-mesenchymal transition state in epithelial tubular cells.

SPAG9 CDH16

1.26e-052124237013185
Pubmed

Corticostriatal LTP requires combined mGluR1 and mGluR5 activation.

GRM1 GRM5

1.26e-052124212559117
Pubmed

Enhanced Function and Overexpression of Metabotropic Glutamate Receptors 1 and 5 in the Spinal Cord of the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis during Disease Progression.

GRM1 GRM5

1.26e-052124231540330
Pubmed

Differential distribution of group I metabotropic glutamate receptors in developing human cortex.

GRM1 GRM5

1.26e-052124220149785
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RARS1 VWA8 KCNAB2 ISOC1 PSMD1 PSMD3 ARHGAP35 GRM5 LRP1B CDC42BPB TRMT10C ERLIN2 KCNQ5 CTNNA2 POLD3

1.39e-0511391241536417873
Pubmed

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

GRM1 GRM4 GRM5

1.56e-0514124321795692
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

PMS1 FLNC RARS1 RPS15 PSMD3 CDC42BPB G6PD

1.71e-05225124731478661
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

NUDT19 FLNC PSMD1 PSMD3 INPP5F ERLIN2 SNRNP200 NEURL4

1.75e-05313124838270169
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

FLNC PSMD1 PSMD3 SPAG9 KIF5A G6PD SNRNP200

2.03e-05231124736597993
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

GRM1 GRM4 GRM5 GRM7

2.05e-0545124425979088
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FLNC RARS1 RPS15 ISOC1 PSMD1 PSMD3 AGPS IFI16 ANKRD27 SF3B3 BAZ1A POLD3 MMP14 G6PD SNRNP200 NIPBL

2.63e-0513531241629467282
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM3A NSD1 EZH1 KMT2A

2.88e-0549124434368113
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

FLNC RARS1 RPS15 PSMD1 CDC42BPB SORCS1 FARSA TRMT10C SF3B3 ANAPC1 SNRNP200 WDR62

3.41e-058091241232129710
Pubmed

Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.

AHI1 CTNNA2 NIPBL

3.47e-0518124333323119
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 G6PD

3.77e-053124218068688
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7

3.77e-053124231645370
Pubmed

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

CYP2A6 CYP2A7

3.77e-053124211960914
Pubmed

Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.

GRM1 GRM5

3.77e-053124219717561
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7

3.77e-05312423346244
Pubmed

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

GBP1 GBP2

3.77e-053124230062052
Pubmed

The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation.

ANKRD27 VTI1B

3.77e-053124223104059
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7

3.77e-05312422733794
Pubmed

Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.

GBP1 GBP2

3.77e-053124226416908
Pubmed

Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.

GRM1 GRM5

3.77e-053124212364493
Pubmed

SIRT1 Activation Attenuates Bone Cancer Pain by Inhibiting mGluR1/5.

GRM1 GRM5

3.77e-053124231270711
Pubmed

Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.

GBP1 GBP2

3.77e-053124232354743
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7

3.77e-05312428297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7

3.77e-05312428188299
Pubmed

Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.

SORCS1 SORCS3

3.77e-053124231095505
Pubmed

GTPase properties of the interferon-induced human guanylate-binding protein 2.

GBP1 GBP2

3.77e-05312428706832
Pubmed

Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.

GRM1 GRM5

3.77e-053124220410124
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7

3.77e-05312428484736
Pubmed

Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.

GBP1 GBP2

3.77e-053124232620042
Pubmed

[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].

GBP1 GBP2

3.77e-053124229089068
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7

3.77e-05312428250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7

3.77e-05312422703500
Pubmed

Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.

GBP1 GBP2

3.77e-053124223248289
Pubmed

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

GBP1 GBP2

3.77e-05312421715024
Pubmed

GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer.

GBP1 GBP2

3.77e-053124233552086
Pubmed

The three sorCS genes are differentially expressed and regulated by synaptic activity.

SORCS1 SORCS3

3.77e-053124215009648
Pubmed

Two families of GTPases dominate the complex cellular response to IFN-gamma.

GBP1 GBP2

3.77e-05312429862701
Pubmed

The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.

GBP1 GBP2

3.77e-053124211726669
Pubmed

Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.

GRM4 GRM7

3.77e-053124233068816
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7

3.77e-05312421417950
Pubmed

GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.

GBP1 GBP2

3.77e-053124238636926
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7

3.77e-053124224045421
Pubmed

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.

SORCS1 SORCS3

3.77e-053124228827148
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7

3.77e-053124232987105
Pubmed

Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.

GRM4 GRM5

3.77e-053124230488581
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7

3.77e-053124222217847
Cytoband10q23-q25

SORCS1 SORCS3

4.33e-054124210q23-q25
Cytoband19q13.11

NUDT19 ANKRD27 RHPN2

2.51e-0445124319q13.11
Cytoband8p11.2

ERLIN2 ADAM2

6.45e-041412428p11.2
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM1 GRM4 GRM5 GRM7

2.33e-088794281
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD1 EZH1 KMT2A

4.36e-0434793487
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

GRM1 GRM5 GRM7 FER POLD3

1.18e-03181795694
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM1 GRM5 GRM7 LRP1B SORCS1 SORCS3 CTNNA2 CDH18

5.17e-091391238a1945b07f177cde40e7eea03a19236ce76165857
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM5 GRM7 LRP1B C1orf141 SORCS3 CTNNA2 CDH18

2.04e-0715012370205318a870e091add66ee4305747dda9f51510d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M KDM3A ZNF407 SPG11 PCGF3 HGS MMP14

4.59e-071691237665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M KDM3A ZNF407 SPG11 PCGF3 HGS MMP14

4.59e-0716912376614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOK6 SZT2 GRM4 GRM7 CCDC13 KEL CDH18

8.74e-071861237bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 MATK KCNAB2 PAK6 GRM1 GRM5 SPTBN4

1.12e-061931237be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 MATK KCNAB2 PAK6 GRM1 GRM5 SPTBN4

1.12e-0619312370c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 MATK KCNAB2 PAK6 GRM1 GRM5 SPTBN4

1.12e-0619312378689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R--|Neuronal / cells hierarchy compared to all cells using T-Statistic

AHI1 RFX2 SORCS1 KCNQ5 SORCS3 MPP7 CDH18

1.42e-062001237dc8702e3cb4ac8c1a9849fc8abf8777f12d55b0b
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R---L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

AHI1 RFX2 SORCS1 KCNQ5 SORCS3 MPP7 CDH18

1.42e-062001237d92d51021ab6d78e9c8f89f7c150181004dcbcbd
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R-|Neuronal / cells hierarchy compared to all cells using T-Statistic

AHI1 RFX2 SORCS1 KCNQ5 SORCS3 MPP7 CDH18

1.42e-062001237cbbb9044283ff9ab63bbfc24d7a9f006b1372705
ToppCellNeuronal-Excitatory-eA(LAMP5_LINC00507)-GLP2R|Neuronal / cells hierarchy compared to all cells using T-Statistic

AHI1 RFX2 SORCS1 KCNQ5 SORCS3 MPP7 CDH18

1.42e-062001237a3e36bbeed19431d07bc205f14f4e0f12bd8f730
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM1 GRM5 GRM7 LRP1B CTNNA2 CDH18

3.54e-061481236d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

USP18 GBP1 GRM5 ADAM2 TDRD6 CDH18

6.39e-061641236362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

SAMD8 SPAG9 EZH1 LRP1B FCHSD2 KMT2A

9.89e-061771236e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 PDE1A ARHGAP40 LRP1B GRHL1

1.02e-05178123635a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M ROR2 GRM4 C1orf141 FBLN1 LAMP3

1.05e-0517912367ae67e1c09a4ce9b3bcec4c48ee9cf2b1cb4e339
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A VWA8 NEK10 SLC43A1 CPM F11

1.09e-0518012369e09b3dfe344b5d50520711513d389865d73a861
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

USP18 GBP1 GBP2 IFI16 BAZ1A LAMP3

1.19e-0518312368f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M GRM1 LRP1B PKHD1L1 SORCS1 KIF5A

1.23e-0518412362cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M GRM1 LRP1B PKHD1L1 SORCS1 KIF5A

1.23e-051841236ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M GRM1 LRP1B PKHD1L1 SORCS1 KIF5A

1.23e-0518412362b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellBAL-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-051851236ae966929fb5bbb08ffcbac76cb21941638727f55
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-0518512363beebaa92275086b1fae5f8c0c3d54016c5ba2aa
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-051851236ceff11cfa679147ccfd0a0f8079e697a6bea34d9
ToppCellBAL-Severe-Myeloid-Macrophage|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-0518512369aea5ed8f9cee5ee933891203aac7adb85d68201
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-05185123642939b294ea3e871274d8b73124c850dc1904fd2
ToppCellSevere_COVID-19-Myeloid-transitional_Macro|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-051851236f7ef0d7740b4cfedc38846e802898c402dc411fd
ToppCellBAL-Severe-Myeloid-Macrophage-transitional_Macro|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M KCNAB2 CPM SLC35F6 LTA4H MMP14

1.27e-0518512367a3612520ae4f0cd61480eadba31eecce001419d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A NEK10 SLC43A1 CPM LRP1B F11

1.35e-05187123685e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A GRM1 GRM7 SORCS1 KCNQ5 CDH18

1.39e-05188123650c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A GRM1 GRM7 LRP1B F11 SORCS3

1.39e-0518812363cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A GRM7 SORCS1 KCNQ5 MPP7 CDH18

1.43e-051891236c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

USP18 GBP1 GBP2 IFI16 BAZ1A LAMP3

1.52e-0519112362da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

CYP2A6 CYP2A7 ARHGAP40 IFI16 GRHL1 DTX4

1.71e-051951236b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CYP2A6 CYP2A7 ARHGAP40 GRM4 GRHL1 DTX4

1.71e-051951236b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

USP18 GBP1 GBP2 IFI16 BAZ1A LAMP3

1.71e-051951236b64d9e1a8834401b4dc501566546647754ae21fc
ToppCelldroplet-Marrow-BM-1m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP18 RIPK3 PSMD1 PSMD3 SF3B3 BAZ1A

1.71e-051951236637b06ef3967b03f7165d102d316e8b7161a817d
ToppCellMild-CD4+_T_activated|Mild / Disease group and Cell class

USP18 GBP1 GBP2 IFI16 BAZ1A LAMP3

1.76e-051961236daa1c3322d81e649161e889e1d78451d2d425d09
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOK6 AHI1 GRM5 SPTBN4 KCNQ5 CDH18

1.87e-0519812360ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

USP18 GBP1 SPAG9 IFI16 KMT2A NIPBL

1.97e-05200123612f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NDST1 PDE1A LRP1B RELL1 CDH18

3.07e-05130123505d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCellCOVID-19-kidney-Technical/muscle|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRM5 GRM7 LRP1B CTNNA2 CDH18

4.22e-05139123513247bcb21c57c808657e0f543d6f134eeea7cc1
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe-9|TCGA-Kidney / Sample_Type by Project: Shred V9

SETMAR ABHD3 SPTBN4 ADAM2 CTNNA2

4.22e-051391235a93b861906d7f01ff715084f99152ec83529f8b3
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe|TCGA-Kidney / Sample_Type by Project: Shred V9

SETMAR ABHD3 SPTBN4 ADAM2 CTNNA2

4.37e-051401235bc5bed94c33129391ca35791febb55cc4cdff989
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

GRM1 GRM5 GRM7 CTNNA2 CDH18

5.34e-051461235c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH7B INPP5F GRM1 TIAM1 SORCS3

5.88e-05149123510ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

USP18 GBP1 GBP2 IFI16 LAMP3

6.46e-051521235b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

GRM5 GRM7 KCNQ5 CTNNA2 CDH18

7.99e-0515912355335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B PKHD1L1 SORCS1 CTNNA2 TDRD6

8.23e-051601235c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1B PKHD1L1 SORCS1 CTNNA2 TDRD6

8.23e-05160123525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 PDE1A ARHGAP40 GRHL1

8.73e-0516212355c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

GRM7 C1orf141 KCNQ5 CTNNA2 CDH18

8.98e-05163123519c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SZT2 CPM INPP5F TIAM1 BFSP2

8.98e-0516312359f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X

PDE1A PKHD1L1 DTX4 EFCAB7 MPP7

8.98e-051631235961c3a1303108afd680365466045f3460a30a7b0
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M DOK6 ABHD3 NRBP2 KEL

9.52e-0516512354f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M CPM LRP1B ADAMTS7 FER

9.52e-05165123537615622c736e43260c38016e7c9e565ac97a3e8
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M DOK6 ABHD3 NRBP2 KEL

9.52e-0516512353e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M CPM LRP1B ADAMTS7 FER

9.52e-051651235640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M CPM LRP1B ADAMTS7 FER

9.52e-051651235f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellICU-SEP-Lymphocyte-T_NK-dnT|ICU-SEP / Disease, Lineage and Cell Type

GPAM KCNQ5 ABCD2 MMP14 BFSP2

9.79e-05166123596d92316cee20b722fe782db9dafcceb8f2c220b
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

A2M CPM LRP1B ADAMTS7 FER

1.06e-041691235fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEK10 GRM5 GRM7 CFAP65 CCDC13

1.06e-04169123514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

A2M CPM LRP1B ADAMTS7 FER

1.09e-041701235c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AHI1 GRM7 SORCS1 KCNQ5 KIF5A

1.25e-0417512358362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AHI1 GRM7 SORCS1 KCNQ5 KIF5A

1.25e-0417512358b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMS1 GRM1 GRM4 KIF5A CDH18

1.25e-04175123565571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 PDE1A ARHGAP40 GRHL1

1.36e-041781235f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellT_cells-ISG-high_CD4+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

USP18 GBP1 GBP2 IFI16 LAMP3

1.39e-041791235af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell(05)_Ciliated-(4)_1wkpi|(05)_Ciliated / shred by cell type and Timepoint

SAMD8 CFAP65 NRBP2 MAPKBP1 ABCD2

1.43e-04180123585fc9b164147b28545e2397d32302eea03ef6346
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A CPM GRM1 LRP1B F11

1.43e-041801235eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A CPM GRM1 LRP1B F11

1.43e-041801235a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

RFX2 SORCS1 FBLN1 KCNQ5 TIAM1

1.47e-0418112352b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC RIPK3 MATK RFX2 WDR62

1.47e-041811235c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNC RIPK3 MATK RFX2 WDR62

1.47e-0418112350ec9621a078d004bbd25a587757d24b5cf162959
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CYP2A6 CYP2A7 ARHGAP40 GRHL1 TSSK1B

1.47e-041811235c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A GRM1 GRM7 KCNQ5 MPP7

1.51e-04182123514a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCellHSPCs-Neutro_prog.|World / Lineage and Cell class

MATK AGPS BAZ1A LTA4H ABCD2

1.51e-041821235f2512354b90f55bf4172c28084bf52cf79e41d8a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-6_RORB_HPCA|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A GRM1 LRP1B SORCS1 KCNQ5

1.54e-041831235c7e94fe3e7669db9304b249979fef7a69c30a143
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A GRM1 LRP1B F11 SPTBN4

1.58e-041841235e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCellControl-CD8+_T_activated|Control / Disease group and Cell class

USP18 GBP1 IDUA TRMT10C LAMP3

1.58e-041841235b86cc48b744b3206880ec1373fe6068e14bf9680
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M PMS1 GRM1 TIAM1 KIF5A

1.63e-041851235cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

USP18 GBP1 GBP2 IFI16 BAZ1A

1.63e-041851235f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A VWA8 NEK10 CPM F11

1.63e-04185123503f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellBAL-Control-Myeloid-MoAM-MoAM4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MATK SPAG9 SORCS1 TDRD6 MMP14

1.63e-04185123529d7ddcb9a2e45f76cd5611f7c52b6df689effd3
ToppCellBAL-Control-Myeloid-MoAM-MoAM4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MATK SPAG9 SORCS1 TDRD6 MMP14

1.63e-041851235780bdb63ef913a09930063286011c9108381d3a9
ToppCellBAL-Control-Myeloid-MoAM-MoAM4|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MATK SPAG9 SORCS1 TDRD6 MMP14

1.63e-041851235274b8acccdfe434d14af4cb32fb615c06ec98435
ToppCellBAL-Control-Myeloid-MoAM-MoAM4-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MATK SPAG9 SORCS1 TDRD6 MMP14

1.63e-041851235b640d9ed6a1e6aa595053065bb992efc0402353e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PDE1A CPM KCNQ5 LTA4H MPP7

1.67e-0418612352ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRM7 LRP1B SORCS1 SORCS3 CTNNA2

1.67e-0418612358915436d09775f2828a7678af203b1082b36e21c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A VWA8 NEK10 CPM F11

1.67e-0418612351850583d23903d08226aeb0edb3e07b0994330e4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRM7 SORCS1 KCNQ5 MPP7 CDH18

1.67e-041861235bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A VWA8 NEK10 CPM F11

1.67e-0418612354dafc215c42e7949f932a3627359c107943b5d6b
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATK KCNAB2 PAK6 GRM5 SPTBN4

1.67e-0418612357278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell10x5'v1-week_12-13-Myeloid_macrophage-stroma-osteoclast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HYAL1 MATK ROR2 GBP2 MMP14

1.67e-041861235c9dfcf7bba7e5ef97ad5d9b7084fba932c91ab68
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A GRM7 SORCS1 KCNQ5 CDH18

1.71e-041871235f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A NEK10 SLC43A1 CPM F11

1.71e-04187123552b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A GRM1 LRP1B F11 SORCS3

1.71e-0418712357ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellnormal_Lung-Myeloid_cells-pDCs|normal_Lung / Location, Cell class and cell subclass

USP18 INPP5F FCHSD2 KCNQ5 HGS

1.71e-041871235d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

USP18 GBP1 GBP2 IFI16 LAMP3

1.75e-0418812356f8946d4710f6e32c937213f99b790b098b8819c
Drugcis-MCG-I

GRM1 GRM4 GRM5 GRM7

5.58e-0881234CID003035584
DrugmM PEP

GRM1 GRM4 GRM5 GRM7

1.00e-0791234CID005311462
DrugAC1N21PP

GRM1 GRM4 GRM5 GRM7

1.00e-0791234CID004014619
Drug1,3-cyclopentanedicarboxylic acid

GRM1 GRM4 GRM5 GRM7

1.00e-0791234CID000107216
DrugNS-105

GRM1 GRM4 GRM5 GRM7

1.66e-07101234CID000198695
Drugcyclobutylene AP5

GRM1 GRM4 GRM5 GRM7

2.60e-07111234CID000126582
DrugMspg

GRM1 GRM4 GRM5 GRM7

5.58e-07131234CID003964410
DrugMSOPPE

GRM1 GRM4 GRM5 GRM7

5.58e-07131234CID005311463
DrugAC1NSKBB

GRM1 GRM4 GRM5 GRM7

5.58e-07131234CID005311256
DrugCbpg

GRM1 GRM4 GRM5

6.13e-0741233CID005311040
DrugMTPG

GRM1 GRM4 GRM5 GRM7

7.79e-07141234CID005311456
Drug2-methyl-6-styrylpyridine

GRM1 GRM4 GRM5 GRM7

7.79e-07141234CID000235382
DrugLuteolin [491-70-3]; Down 200; 14uM; PC3; HT_HG-U133A

AHI1 ARHGAP35 IFI16 NEK1 FCHSD2 TIAM1 BAZ1A MMP14 NIPBL

9.85e-0719112396658_DN
Drugethylglutamate

GRM1 GRM4 GRM5 GRM7

1.40e-06161234CID000014241
Drug2-PMPA

GRM1 GRM4 GRM5 GRM7

1.40e-06161234CID010130754
Drug3HPG

GRM1 GRM4 GRM5 GRM7

1.83e-06171234CID000001217
Drugacromelic acid A

GRM1 GRM4 GRM5 GRM7

2.34e-06181234CID000108086
Drugaminocyclopentane

GRM1 GRM4 GRM5 GRM7

2.95e-06191234CID000002906
DrugAC1MBZ3L

GRM1 GRM4 GRM5

3.04e-0661233CID002733524
Drug4-carboxy-3-hydroxyphenylglycine

GRM1 GRM4 GRM5 GRM7

3.67e-06201234CID000001297
Drug3,4-dihydroxyphenylglycine

GRM1 GRM4 GRM5 GRM7

4.52e-06211234CID000027915
Drugphorbol 12,13-diacetate

SPAG9 GRM1 GRM4 GRM5 GRM7

6.03e-06481235CID000072293
DrugMSOP

GRM1 GRM4 GRM5 GRM7

6.63e-06231234CID003964633
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A

RARS1 ABHD3 SPAG9 CPM IFI16 FIG4 LTA4H G6PD

7.89e-0618612381612_UP
DrugRS)-2-chloro-5-hydroxyphenylglycine

GRM1 GRM4 GRM5 GRM7

7.93e-06241234CID003645780
DrugAC1NQH9B

GRM1 GRM4 GRM5 GRM7

1.11e-05261234CID005221504
DrugDeferoxamine mesylate [138-14-7]; Down 200; 6uM; MCF7; HT_HG-U133A

A2M KCNAB2 KLHL22 FBLN1 KMT2A KIF5A MAPKBP1 WDR62

1.16e-0519612383936_DN
DrugDiltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; HL60; HG-U133A

RARS1 PSMD1 IFI16 FCHSD2 KMT2A MAPKBP1 NIPBL GPN3

1.29e-0519912382032_DN
DrugOrnidazole [16773-42-5]; Up 200; 18.2uM; PC3; HT_HG-U133A

NDST1 AHI1 EZH1 RFX2 TIAM1 KMT2A ADAM2 MMP14

1.29e-0519912382109_UP
DrugPBDA

GRM1 GRM4 GRM5 GRM7

1.99e-05301234CID000004408
Drugalpha-methyl-4-carboxyphenylglycine

GRM1 GRM4 GRM5 GRM7

2.59e-05321234CID000001222
Drugxanthanoic acid

GRM1 GRM5

2.89e-0521232CID000065736
Drug1-aminoindan-1,5-dicarboxylic acid

GRM1 GRM4 GRM5 GRM7

2.94e-05331234CID000002071
DrugAMN082

GRM1 GRM5 GRM7

3.27e-05121233CID001894360
DrugCPPG

GRM1 GRM4 GRM5 GRM7

3.32e-05341234CID000002878
Drug1m5d

GRM1 GRM4 GRM5 GRM7

3.73e-05351234CID000447082
Drugbenzyloxyaspartate

GRM1 GRM4 GRM5 GRM7

4.67e-05371234CID004133412
DrugAC1L9FMM

GRM1 GRM4 GRM5 GRM7 ABCD2

4.75e-05731235CID000444055
DrugL-BMAA

GRM1 GRM4 GRM5 GRM7

5.19e-05381234CID000028558
Drug4CPG

GRM1 GRM4 GRM5 GRM7

5.19e-05381234CID000005115
Drug4-aminopyrrolidine-2,4-dicarboxylate

GRM1 GRM4 GRM5 GRM7

5.76e-05391234CID003331970
DrugDETC-MeSO

GRM1 GRM4 GRM5 GRM7

5.76e-05391234CID003035711
Drug2-amino-3-phosphonopropionic acid

GRM1 GRM4 GRM5 GRM7 GRHL1

5.77e-05761235CID000003857
DrugL000369

GRM1 GRM4 GRM5 GRM7

7.04e-05411234CID003931705
DrugAC1NNRU4

GRM1 GRM4 GRM5 GRM7

7.04e-05411234CID005126051
DrugU-U-U

MATK RPS15 PSMD3 FARSA

7.04e-05411234CID005289515
Drugbutenafine

GRM1 GRM4 GRM5 GRM7

7.74e-05421234CID000002484
DrugLY341495

GRM1 GRM4 GRM5 GRM7

8.50e-05431234CID006324636
DrugJoro spider toxin

GRM1 GRM4 GRM5 GRM7

8.50e-05431234CID000119582
Drugfenobam

GRM1 GRM5

8.65e-0531232CID000162834
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7

8.65e-0531232CID000068481
DrugHomochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; MCF7; HT_HG-U133A

A2M FLNC AHI1 IDUA RFX2 FBLN1 SNRNP200

8.75e-0519312375998_UP
DrugLetrozole [112809-51-5]; Down 200; 14uM; PC3; HT_HG-U133A

NDST1 ARHGAP35 EZH1 GRM4 KLHL22 TIAM1 MMP14

8.75e-0519312374240_DN
Drug6-Hydroxytropinone [5932-53-6]; Down 200; 25.8uM; PC3; HT_HG-U133A

SZT2 ARHGAP35 GRM1 GRM4 FBLN1 ADAM2 MMP14

9.33e-0519512374250_DN
DrugThalidomide [50-35-1]; Up 200; 15.4uM; MCF7; HT_HG-U133A

A2M NDST1 AHI1 KCNAB2 SORCS3 MMP14 CDH18

9.33e-0519512375990_UP
DrugGuanethidine sulfate [60-02-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A

NDST1 SZT2 KCNAB2 ARHGAP35 IDUA SPTBN4 SORCS3

9.63e-0519612373171_UP
DrugKetorolac tromethamine [74103-07-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A

A2M NDST1 SLC43A1 GBP1 GRM1 IDUA RFX2

1.03e-0419812375988_UP
Drughaloperidol; Down 200; 10uM; MCF7; HT_HG-U133A

AHI1 ARHGAP35 EZH1 NEK1 TIAM1 DTX4 WDR62

1.03e-0419812377003_DN
DrugTranexamic acid [1197-18-8]; Down 200; 25.4uM; PC3; HT_HG-U133A

AHI1 RARS1 SLC43A1 KCNAB2 NSD1 GBP1 MMP14

1.03e-0419812372085_DN
DrugMinaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; PC3; HT_HG-U133A

NDST1 CPM GRM1 KLHL22 FBLN1 ADAM2 MMP14

1.03e-0419812374230_DN
DrugOxytetracycline dihydrate [6153-64-6]; Down 200; 8uM; HL60; HG-U133A

NDST1 MED6 SLC43A1 FBXL5 FBLN1 MAPKBP1 NIPBL

1.03e-0419812371553_DN
Drugmemantine

CPM GRM1 GRM4 GRM5 GRM7

1.04e-04861235CID000004054
DrugPHA-00745360 [351320-33-7]; Down 200; 1uM; PC3; HT_HG-U133A

KCNAB2 ARHGAP35 PCGF3 KLHL22 FBLN1 ADAM2 MMP14

1.06e-0419912374562_DN
DrugAzathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A

NDST1 RARS1 CPM ARHGAP35 FBXL5 FER MAPKBP1

1.06e-0419912371528_DN
DrugIPSP

SPAG9 GRM1 GRM4 GRM5 GRM7

1.10e-04871235CID000022083
Drugcysteine sulfinic acid

GRM1 GRM4 GRM5 GRM7

1.11e-04461234CID000000109
DrugAC1L1R04

CYP2A6 COQ6 NSD1 HGS

1.21e-04471234CID000008439
Drughexachlorophene

GRM1 GRM4 GRM5 GRM7 F11

1.29e-04901235CID000003598
Drugmethylenecyclopropylglycine

GRM1 GRM4 GRM5 GRM7

1.42e-04491234CID000441452
DrugL-CCG-I

GRM1 GRM4 GRM5 GRM7

1.54e-04501234CID000001271
DrugLY354740

GRM1 GRM4 GRM5 GRM7

1.67e-04511234CID000114827
Drug3H-MA

COQ6 KEL

1.72e-0441232CID000194573
DrugAC1L1EKQ

GRM1 GRM4 GRM5 GRM7

1.80e-04521234CID000002834
DrugN-Ac-D-E

GRM1 GRM4 GRM5 GRM7

1.94e-04531234CID000005255
Drug2-phenylglycine

GRM1 GRM4 GRM5 GRM7

2.24e-04551234CID000003866
Diseaseprimary autosomal recessive microcephaly 2 with or without cortical malformations (implicated_via_orthology)

MAPKBP1 WDR62

1.67e-0521212DOID:0070293 (implicated_via_orthology)
Diseasehemolytic anemia (implicated_via_orthology)

A2M G6PD

1.67e-0521212DOID:583 (implicated_via_orthology)
DiseaseAdenocarcinoma of large intestine

PMS1 MATK ROR2 CDC42BPB TNNI3K

4.84e-05961215C1319315
DiseaseAttention Deficit Disorder

GRM1 GRM5 GRM7

9.78e-05221213C0041671
DiseaseMinimal Brain Dysfunction

GRM1 GRM5 GRM7

9.78e-05221213C1321905
DiseaseIntellectual Disability

NDST1 AHI1 RARS1 NSD1 ERLIN2 KCNQ5 KIF5A CTNNA2 WDR62

9.81e-054471219C3714756
DiseaseEpilepsy, Benign Psychomotor, Childhood

GRM1 GRM4 GRM5

1.12e-04231213C0393672
DiseaseEpilepsy, Lateral Temporal

GRM1 GRM4 GRM5

1.12e-04231213C0393682
DiseaseUncinate Epilepsy

GRM1 GRM4 GRM5

1.12e-04231213C0014558
DiseaseEpilepsy, Temporal Lobe

GRM1 GRM4 GRM5

1.12e-04231213C0014556
DiseaseAttention deficit hyperactivity disorder

GRM1 GRM5 GRM7

1.28e-04241213C1263846
DiseaseColorectal Carcinoma

CYP2A6 FLNC PAK6 GRM1 TNNI3K KCNQ5 TIAM1 RHPN2 POLD3 ABCD2 SNRNP200

1.53e-0470212111C0009402
DiseaseWeaver syndrome

NSD1 KMT2A

1.65e-0451212C0265210
DiseaseProfound Mental Retardation

NDST1 AHI1 NSD1 ERLIN2 WDR62

2.77e-041391215C0020796
DiseaseMental Retardation, Psychosocial

NDST1 AHI1 NSD1 ERLIN2 WDR62

2.77e-041391215C0025363
DiseaseMental deficiency

NDST1 AHI1 NSD1 ERLIN2 WDR62

2.77e-041391215C0917816
Diseasetheobromine measurement

CYP2A6 CPM

4.59e-0481212EFO_0021179
DiseaseCornelia De Lange Syndrome

KMT2A NIPBL

4.59e-0481212C0270972
Disease3-hydroxypropylmercapturic acid measurement

ISOC1 GPAM CPM PAK6 GRM7 LRP1B KMT2A

6.40e-043521217EFO_0007014
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7

1.07e-03121212EFO_0007794
Diseaselower face morphology measurement

ROR2 RFX2 LRP1B ANAPC1

1.07e-031091214EFO_0010948
DiseaseSmall cell carcinoma of lung

PAK6 FER KMT2A

1.43e-03541213C0149925
DiseaseMalformations of Cortical Development

NDST1 WDR62

1.47e-03141212C1955869
DiseaseSpastic Paraplegia, Hereditary

ERLIN2 KIF5A

1.47e-03141212C0037773
DiseaseCortical Dysplasia

NDST1 WDR62

1.47e-03141212C0431380
Diseasediffuse idiopathic skeletal hyperostosis

ROR2 POLD3

1.69e-03151212EFO_0007236
Diseaseshigellosis

C1orf141 MPP7

1.93e-03161212EFO_0005585
Diseasepancreatitis

HECTD4 MORC4

1.93e-03161212EFO_0000278
DiseaseAmyotrophic lateral sclerosis

SPG11 FIG4

2.18e-03171212cv:C0002736
Diseasefactor XI measurement, Ischemic stroke

HECTD4 F11

2.18e-03171212EFO_0004694, HP_0002140
Diseasevenous thromboembolism, fibrinogen measurement

HECTD4 F11 TTC17

2.66e-03671213EFO_0004286, EFO_0004623
Diseasecystathionine measurement

DOK6 CTNNA2

2.72e-03191212EFO_0010474
Diseaseemphysema pattern measurement

CYP2A6 VWA8

2.72e-03191212EFO_0005850
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7

2.72e-03191212EFO_0007872
Diseasepulmonary arterial hypertension

PDE1A TMEM217

3.65e-03221212EFO_0001361
Diseasecotinine measurement

CYP2A6 CTNNA2

3.99e-03231212EFO_0007813
Diseasegranulocyte count

AHI1 HECTD4 PSMD3 PCGF3 IFI16

4.02e-032541215EFO_0007987
Diseaseunipolar depression

CPM GRM5 GRM7 CDC42BPB ANKRD27 TRMT10C KCNQ5 FIG4 FER SORCS3 SNRNP200 CDH18

4.02e-03120612112EFO_0003761

Protein segments in the cluster

PeptideGeneStartEntry
NMERIYHEFQETVGL

EPG5

1451

Q9HCE0
KQFVGYLDKAVIHEM

C1orf141

326

Q5JVX7
YMEAVIHEIQRFGDV

CYP2A6

351

P11509
IAFYRGHKVEMKQLQ

ABCD2

306

Q9UBJ2
HVAQQEAEMFKRYNG

AHI1

921

Q8N157
EPQQDFAKYIEMHVI

ADAM2

171

Q99965
VQFVIDAVYAMGHAL

GRM4

406

Q14833
YIVENDVIMHALTKQ

COQ6

141

Q9Y2Z9
DRVFKQFVQAMVEHG

ABHD3

391

Q8WU67
DMEVGITIQHAYEKQ

DTX4

106

Q9Y2E6
VEYMAKVHALEQVSQ

BFSP2

116

Q13515
TLVVADAKMVEYHGQ

ADAMTS7

246

Q9UKP4
YEMKLHTEAQIQEEG

A2M

316

P01023
VVHYLAMALFQIEQG

BAZ1A

1076

Q9NRL2
YIREGHEKQADIMIF

MMP14

166

P50281
QYIGHDRTMQDIVYK

PCGF3

66

Q3KNV8
KAIVMFEGRHQFEEL

NSD1

381

Q96L73
IYRIDHYLGKEMVQN

G6PD

196

P11413
QHLQDVDIEPYVSKM

SPAG9

1121

O60271
GHIKRMQEVYNFNAI

LTA4H

516

P09960
VQYVVDHAMKIVFLN

ANAPC1

236

Q9H1A4
NLMKQAVEIYVHHEI

ANKRD27

206

Q96NW4
NVPTVDIHMKQVGYE

PLOD3

606

O60568
NEVVIMRDYQHFNVV

PAK6

451

Q9NQU5
SLYGDQIDMHRKFVV

ISOC1

56

Q96CN7
HYIMVKGSIQQEELT

nan

96

O00370
IQHQYLMPENVVEEK

NRBP2

321

Q9NSY0
HVQDSKMGFVINAIY

GRM5

391

P41594
VVHMKVYDKEAQQGS

LRP1B

1821

Q9NZR2
YIVMEHVSKGNLVNF

MATK

301

P42679
KILHLVMADGAYQED

NEK1

1241

Q96PY6
EIMKEGKQFHRIVTY

NUDT19

331

A8MXV4
QEQMVELKYSHLFIG

CFAP65

1251

Q6ZU64
VKDVIEQYSAGHLDM

KCNQ5

546

Q9NR82
NKMLEYLVTGGQEHE

SLC43A1

326

O75387
QHMFVLEQEEYKREG

MYH7B

536

A7E2Y1
GEEQHTVDKLVNMTY

NEK10

176

Q6ZWH5
ALHVYNEVMSVGQKY

PDPR

686

Q8NCN5
IVHAVQAGIFVERMY

PDE1A

121

P54750
EVYVKHMGNRVYNVT

FLNC

2681

Q14315
MESQYGHLFDKIIIN

MPP7

531

Q5T2T1
QLVEIDKKYAGFIHM

NIPBL

2341

Q6KC79
MVQKFLGVTNTIDYH

NDST1

791

P52848
ETIYQGIKHAVVMFQ

LAMP3

316

Q9UQV4
AAVQKAIAHYEQQMG

GBP1

326

P32455
VEKAIAHYEQQMGQK

GBP2

326

P32456
LVETYGKIMNHEERF

CDC42BPB

286

Q9Y5S2
INLEFLKAHTMYQVG

HECTD4

3871

Q9Y4D8
EYHMFQREKVEVQLP

KCNAB2

216

Q13303
VAQVAEITYGQKVME

ERLIN2

221

O94905
HAVLKLEMNYVVGGV

FBLN1

671

P23142
GILVNMDDNIVKHYS

GRHL1

581

Q9NZI5
MEQEEVLIHGVSYNA

KLHL22

86

Q53GT1
VKNVIYHAVKDAVAM

KDM3A

1296

Q9Y4C1
MNIVLQHIDFAIQYG

GPN3

241

Q9UHW5
IHIINAEMENYEAGV

CTNNA2

551

P26232
NYHRQEGMEAFLKTV

CPM

21

P14384
FQTREGEMIYQKVHS

DOK6

211

Q6PKX4
DAKVMDGYENIIVHT

EFCAB7

541

A8K855
KKSYIGVHQQIEAEM

FER

111

P16591
GHAIYKVEDTNMIYI

FIG4

121

Q92562
YMEAVIHEIQRFGDV

CYP2A7

351

P20853
MYHEILGQVKSVFLQ

CCDC13

691

Q8IYE1
FGVQEIIIHDQYKMA

F11

461

P03951
VTYAAMVVKVIAQHQ

IDUA

316

P35475
LKGLEVINDYHFRMV

IFI16

11

Q16666
AKYIVSVGYQHDMIV

MAPKBP1

146

O60336
HYSVVIQAKDMAGQV

CDH18

231

Q13634
QVYHACAMQIVKDVL

KIF5A

61

Q12840
GKVQFVIDAVYAMAH

GRM7

406

Q14831
DGQKHIVIFAMRKIY

KMT2A

3921

Q03164
GKSQMYVQHRVAEAF

HYAL1

256

Q12794
MHEQIENEYIIGLLQ

FBXL5

56

Q9UKA1
VNIMKALDGNVYDHL

FCHSD2

231

O94868
HEGVLNIDDYKIQMN

GRM1

501

Q13255
MELFQAKDHYILQQG

INPP5F

1

Q9Y2H2
DIQDIIYRMKHQFGN

PMS1

896

P54277
DLYGMAVKVTIVHNN

NEURL4

471

Q96JN8
EYQLQVTLEMQDGHV

CDH16

91

O75309
NQMVGIEYILLHAQE

MED6

61

O75586
ADMIIYVVDNGQSVH

RARS1

401

P54136
TYHGQQFLEIKMAER

SZT2

2791

Q5T011
HVNVTFVDYGDREMV

TDRD6

846

O60522
ELVGHKVNLQMVYDS

FARSA

476

Q9Y285
QKIHIDVLEEMGYNS

SAMD8

76

Q96LT4
FYVLEQQHVGLAVDM

NBPF10

1636

Q6P3W6
YVLEQQHVGLAVDMD

NBPF10

1881

Q6P3W6
FYVLEQQHVGLAVDM

NBPF10

2856

Q6P3W6
YVLEQQHVGLAVDMD

NBPF10

3101

Q6P3W6
VDVVMNLQFHYIEKL

RFX2

381

P48378
YAQVQHDKEQEMIGS

SORCS3

1156

Q9UPU3
YVLFIQERDVHKGMF

GPAM

111

Q9HCL2
HMGYRQAEFQILKAE

MORC4

831

Q8TE76
DMVGYAQETQHEKIL

PSMD1

531

Q99460
IREHVYNGQVMETFV

SETMAR

196

Q53H47
DFVHLVAQIAAGMEY

ROR2

591

Q01974
GVHVNQAKQMLYDYV

POLD3

31

Q15054
SVYMDIYGKHQKQII

ARHGAP35

471

Q9NRY4
KVGEVYQQLHAAMSQ

RHPN2

316

Q8IUC4
MKKNIYGNIEDLVVH

AGPS

321

O00116
YGNIEDLVVHIKMVT

AGPS

326

O00116
VEKLYLGHFQENMQI

SPG11

796

Q96JI7
TFNQVEIKPEMIGHY

RPS15

101

P62841
QLHEYNDIKDVGQML

SWI5

196

Q1ZZU3
HVLFMQENKYKEAIG

TTC30B

466

Q8N4P2
INHEKGYVQSKEMID

PSMD3

451

O43242
AEGAAEVVQIMVHYQ

ARHGAP40

451

Q5TG30
INEMQKIHEEFGAVF

TIAM1

1231

Q13009
LKEVVLGMFYLHDQN

RIPK3

121

Q9Y572
TVGQIVHYIMKNEAN

RELL1

116

Q8IUW5
INNYDGKVHGEEEMI

EZH1

151

Q92800
KVVQDTYQIMKVEGH

HGS

126

O14964
SVEVLMNYHQGLKTE

SPTBN4

1976

Q9H254
KVGEVYQQLHAAMSQ

RHPN2P1

231

A8MT19
NMVTGRIEYVEVFHA

PKHD1L1

2451

Q86WI1
VNHFTLGNVYVAMEE

TTC17

1086

Q96AE7
SQKAEVIMNYHVGET

SF3B3

1086

Q15393
AIQMVLEEKFVYKHN

SLC35F6

191

Q8N357
KVVYVENDIQHLQDM

WDR62

461

O43379
EIVYEKIMEHAGKNQ

SNRNP200

706

O75643
VIIMDTQYYNGKIHA

SNRNP200

1661

O75643
QYELFAVIAHVGMAD

USP41

301

Q3LFD5
TSHGKVYIVMELAVQ

TSSK1B

81

Q9BXA7
HVLFMQENKYKEAIG

TTC30A

466

Q86WT1
QYELFAVIAHVGMAD

USP18

301

Q9UMW8
IGVQLQEHSYLEKGM

ZNF407

801

Q9C0G0
VDMYLIFEQKHLGNG

TMEM217

26

Q8N7C4
VNLSSMEDGIKHVYQ

SORCS1

846

Q8WY21
MEDGIKHVYQNVGIF

SORCS1

851

Q8WY21
DVLFYDNIQHVIVME

VWA8

751

A3KMH1
IAVDVAKGMEYLHNL

TNNI3K

566

Q59H18
KYGIYAVENEHMNRL

VTI1B

111

Q9UEU0
NVMTTFRHDKVYVIG

TRMT10C

296

Q7L0Y3
VVHDVEYLKNMSQLV

KEL

336

P23276