Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K36me/H3K36me2 demethylase activity

KDM2B KDM2A

6.94e-064222GO:0140680
GeneOntologyMolecularFunctionunmethylated CpG binding

KDM2B KDM2A

5.19e-0510222GO:0045322
GeneOntologyMolecularFunctionhistone H3K36 demethylase activity

KDM2B KDM2A

6.34e-0511222GO:0051864
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM2B KDM2A

4.30e-0428222GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM2B KDM2A

5.28e-0431222GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM2B KDM2A

5.63e-0432222GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM2B KDM2A

1.07e-0344222GO:0032451
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM2B KDM2A

2.31e-0365222GO:0016706
GeneOntologyMolecularFunctionzinc ion binding

MMP20 KDM2B KDM2A TRAF3 ARIH2

2.44e-03891225GO:0008270
GeneOntologyBiologicalProcessthird ventricle development

ATP1B2 KDM2B

1.08e-055222GO:0021678
GeneOntologyBiologicalProcessprotein demethylation

KDM2B KDM2A

4.86e-0510222GO:0006482
GeneOntologyBiologicalProcessprotein dealkylation

KDM2B KDM2A

4.86e-0510222GO:0008214
GeneOntologyBiologicalProcesslateral ventricle development

ATP1B2 KDM2B

9.81e-0514222GO:0021670
GeneOntologyBiologicalProcessneural tube closure

KDM2B KDM2A SFRP5

2.29e-04113223GO:0001843
GeneOntologyBiologicalProcesstube closure

KDM2B KDM2A SFRP5

2.35e-04114223GO:0060606
GeneOntologyBiologicalProcessprimary neural tube formation

KDM2B KDM2A SFRP5

2.73e-04120223GO:0014020
GeneOntologyBiologicalProcessdemethylation

KDM2B KDM2A

2.96e-0424222GO:0070988
GeneOntologyBiologicalProcessneural tube formation

KDM2B KDM2A SFRP5

3.77e-04134223GO:0001841
DomainPHD_4

KDM2B KDM2A

3.97e-063222PF16866
Domainzf-CXXC

KDM2B KDM2A

7.24e-0511222PF02008
DomainZF_CXXC

KDM2B KDM2A

7.24e-0511222PS51058
DomainZnf_CXXC

KDM2B KDM2A

7.24e-0511222IPR002857
DomainLeu-rich_rpt_Cys-con_subtyp

KDM2B KDM2A

2.24e-0419222IPR006553
DomainLRR_CC

KDM2B KDM2A

2.24e-0419222SM00367
DomainJmjC

KDM2B KDM2A

3.60e-0424222PF02373
DomainJMJC

KDM2B KDM2A

6.43e-0432222PS51184
DomainJmjC_dom

KDM2B KDM2A

6.43e-0432222IPR003347
DomainJmjC

KDM2B KDM2A

6.84e-0433222SM00558
DomainFBOX

KDM2B KDM2A

1.69e-0352222SM00256
Domain-

KDM2B KDM2A TRAF3 ARIH2

1.71e-034492243.30.40.10
DomainZnf_RING/FYVE/PHD

KDM2B KDM2A TRAF3 ARIH2

1.85e-03459224IPR013083
DomainF-box

KDM2B KDM2A

2.80e-0367222PF00646
DomainFBOX

KDM2B KDM2A

3.22e-0372222PS50181
DomainF-box_dom

KDM2B KDM2A

3.49e-0375222IPR001810
DomainZnf_PHD-finger

KDM2B KDM2A

3.86e-0379222IPR019787
DomainPHD

KDM2B KDM2A

4.87e-0389222SM00249
DomainZnf_PHD

KDM2B KDM2A

5.09e-0391222IPR001965
DomainZF_PHD_2

KDM2B KDM2A

5.53e-0395222PS50016
DomainZF_PHD_1

KDM2B KDM2A

5.65e-0396222PS01359
DomainZnf_FYVE_PHD

KDM2B KDM2A

1.28e-02147222IPR011011
DomainZnf_RING_CS

TRAF3 ARIH2

1.56e-02163222IPR017907
Pubmed

Biological Functions of the KDM2 Family of Histone Demethylases.

KDM2B KDM2A

3.82e-07222237751135
Pubmed

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.

KDM2B KDM2A

3.82e-07222231363749
Pubmed

Combined expression levels of KDM2A and KDM2B correlate with nucleolar size and prognosis in primary breast carcinomas.

KDM2B KDM2A

3.82e-07222232901907
Pubmed

Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.

KDM2B KDM2A

1.15e-06322226004508
Pubmed

A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.

KDM2B KDM2A

1.15e-06322230033217
Pubmed

Histone demethylation by a family of JmjC domain-containing proteins.

KDM2B KDM2A

2.29e-06422216362057
Pubmed

The human IL-3/granulocyte-macrophage colony-stimulating factor locus is epigenetically silent in immature thymocytes and is progressively activated during T cell development.

MMP20 ERCC2

3.82e-06522220147630
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

LARS1 STARD7 KDM2A TRAF3 BSCL2 ERCC2 YTHDF3

1.03e-05129722733545068
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KDM2B KDM2A

1.71e-051022229276034
Pubmed

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.

KDM2B KDM2A

3.46e-051422221220025
Pubmed

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

KDM2B KDM2A

3.46e-051422217463251
Pubmed

The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators.

KDM2B KDM2A

3.99e-051522225463925
Pubmed

The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types.

KDM2B KDM2A

7.21e-052022237073980
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

MMP20 CDC25B KDM2A TRAF3 ARIH2

7.87e-0573022534857952
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM2B KDM2A

7.96e-052122227626377
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

ATP1B2 CDC25B CFH ERCC2

8.26e-0537422419625176
Pubmed

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

MMP20 ERCC2

8.76e-052222210932192
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

ATP1B2 CDC25B CFH ERCC2

8.87e-0538122418676680
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

ATP1B2 CDC25B CFH ERCC2

8.96e-0538222419170196
Pubmed

CPEB2-eEF2 interaction impedes HIF-1α RNA translation.

ATP1B2 BSCL2

1.05e-042422222157746
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

ATP1B2 CDC25B CFH ERCC2

1.30e-0442122419692168
Pubmed

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

KDM2B KDM2A

2.12e-043422230894540
Pubmed

A family of mammalian F-box proteins.

KDM2B KDM2A

3.24e-044222210531037
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM2B KDM2A

4.41e-044922234368113
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

KDM2A ERCC2

5.56e-045522227114453
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM2B KDM2A

5.97e-045722218022353
CytobandEnsembl 112 genes in cytogenetic band chr8q12

YTHDF3 TMEM68

8.94e-0492222chr8q12
GeneFamilyZinc fingers CXXC-type

KDM2B KDM2A

3.66e-0512142136
GeneFamilyF-box and leucine rich repeat proteins

KDM2B KDM2A

1.16e-0421142558
GeneFamilyPHD finger proteins|Lysine demethylases

KDM2B KDM2A

1.52e-0424142485
GeneFamilyPHD finger proteins

KDM2B KDM2A

2.14e-039014288
CoexpressionGSE3982_MAST_CELL_VS_NEUTROPHIL_UP

LARS1 STARD7 BSCL2 ERCC2

1.74e-05199214M5432
CoexpressionGSE40274_FOXP3_VS_FOXP3_AND_PBX1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP

ELOVL5 CDC25B TM6SF1 BSCL2

1.78e-05200214M9181
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-double_negative_T_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 BSCL2 MARVELD2 ARIH2

1.30e-06168224de1042267407719f19eb3f580a5df0c9cd0e8273
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

ATP1B2 CFH BSCL2

6.47e-05160223bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

8.87e-05178223ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.47e-0518222382ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.47e-05182223a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.47e-05182223d568a8aec7e27ce632e248baea2ccd0e8dd255ac
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.47e-05182223e89cc30db8e5c77a8bbddd1d5a4b5af09f1ccd67
ToppCelldroplet-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 CFH SFRP5

9.63e-05183223ddc45fb591ba0ce3fa05c08051d58286a89ef835
ToppCelldroplet-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 CFH SFRP5

9.63e-05183223a253ad65673fce6cb453e709cb235ce7cbfa18b7
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.94e-051852233d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

9.94e-05185223995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-CLDN10+_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GJB1 MARVELD2 SFRP5

1.01e-0418622356d2f463800d189212ea0acaaf7db09b65a54eb6
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.01e-04186223adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.01e-04186223ea936e66ae4b7b40564711fad60ac0137327995f
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.03e-04187223f2af79a20438108c814a73f9e24cd986d537237f
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.03e-04187223a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.04e-041882238385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.04e-04188223cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP1B2 GJB1 SFRP5

1.08e-04190223e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL5 ATP1B2 SFRP5

1.09e-0419122360bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL5 ATP1B2 SFRP5

1.16e-041952230bdf845939bc4b8cc94f2808aea60f818425b076
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GJB1 MARVELD2 SFRP5

1.25e-04200223eef5f6bd9ff5d985def8befcf45786234317f144
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GJB1 MARVELD2 MGAM2

1.25e-042002234b1ae9f71f0fe998b06fa580885572d1fc1544e2
Diseasemacular degeneration (is_implicated_in)

CFH ERCC2

1.84e-0427222DOID:4448 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
YTYPYAYYMESGPRK

ARIH2

426

O95376
RRPYFPVAVGKYYSY

CFH

341

P08603
PAYKKNSYGVHPYYM

MGAM2

1116

Q2M2H8
YSYYGLSSVPSMRPY

ELOVL5

181

Q9NYP7
MYFPYYGKKFHVNYT

ATP1B2

226

P14415
YPSLYYPEMYILKGG

CDC25B

511

P30305
YFPYDYIYPEQFSYM

ERCC2

11

P18074
PNKFRYPFYYEMCWY

KDM2A

321

Q9Y2K7
QPKFRYPFYYEMCWY

KDM2B

351

Q8NHM5
EAVFMYVFYLLYPGY

GJB1

146

P08034
SMYGGYYYTGPKTPF

MARVELD2

241

Q8N4S9
RPFYQKTAPYVPMYY

CSN3

36

P07498
VPMYYVPNSYPYYGT

CSN3

46

P07498
VFLYGSFYYSYMPTV

BSCL2

46

Q96G97
YYGPFIFTYMRPKSY

OR2AJ1

251

Q8NGZ0
SALMYPTYKYKNPYG

MMP20

241

O60882
KFMFSYPCSLYYPFF

SFRP5

296

Q5T4F7
TSKGKYFVTFPYPYM

LARS1

41

Q9P2J5
YMPSYYAPSIGFPYS

YTHDF3

56

Q7Z739
YSQPFYTGYFGYKMC

TRAF3

441

Q13114
YEKFRYPFAPMYGGF

TMEM68

256

Q96MH6
VTHFPYPMYSRDYVY

STARD7

216

Q9NQZ5
YMFYSVPYFVTALYG

TM6SF1

271

Q9BZW5