Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DUF4704	NBEAL1 NBEA	2.64e-04	5	97	2	IPR031570
Domain	DUF4704	NBEAL1 NBEA	2.64e-04	5	97	2	PF15787
Domain	PH_BEACH	NBEAL1 NBEA	3.95e-04	6	97	2	PF14844
Domain	Desmosomal_cadherin	DSC2 DSC3	5.51e-04	7	97	2	IPR009122
Domain	Cadherin_pro	DSC2 DSC3	5.51e-04	7	97	2	PF08758
Domain	Cadherin_pro	DSC2 DSC3	7.32e-04	8	97	2	SM01055
Domain	PH-BEACH_dom	NBEAL1 NBEA	7.32e-04	8	97	2	IPR023362
Domain	Cadherin_pro_dom	DSC2 DSC3	7.32e-04	8	97	2	IPR014868
Domain	-	NBEAL1 NBEA	7.32e-04	8	97	2	2.30.29.40
Domain	PH_BEACH	NBEAL1 NBEA	7.32e-04	8	97	2	PS51783
Domain	BEACH	NBEAL1 NBEA	9.39e-04	9	97	2	PS50197
Domain	Beach	NBEAL1 NBEA	9.39e-04	9	97	2	PF02138
Domain	-	NBEAL1 NBEA	9.39e-04	9	97	2	1.10.1540.10
Domain	Beach	NBEAL1 NBEA	9.39e-04	9	97	2	SM01026
Domain	BEACH_dom	NBEAL1 NBEA	9.39e-04	9	97	2	IPR000409
Pubmed	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.	RNPEPL1 PALB2 TRAFD1 CDC25B	2.33e-05	58	99	4	17554300
Pubmed	Assignment of the human genes for desmocollin 3 (DSC3) and desmocollin 4 (DSC4) to chromosome 18q12.	DSC2 DSC3	2.40e-05	3	99	2	7774948
Pubmed	Mediator modulates Gli3-dependent Sonic hedgehog signaling.	GLI3 MED12	2.40e-05	3	99	2	17000779
Pubmed	cDNA cloning and expression of a novel human desmocollin.	DSC2 DSC3	2.40e-05	3	99	2	7929347
Pubmed	New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond.	PPRC1 PPARGC1B	2.40e-05	3	99	2	25495651
Pubmed	Structure and function of desmosomal proteins and their role in development and disease.	DSC2 DSC3	2.40e-05	3	99	2	14523549
Pubmed	Desmocollin switching in colorectal cancer.	DSC2 DSC3	2.40e-05	3	99	2	17088906
Pubmed	MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.	GLI3 MED12	2.40e-05	3	99	2	23091001
Pubmed	The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.	DSC2 DSC3	2.40e-05	3	99	2	23975055
Pubmed	Compositionally different desmosomes in the various compartments of the human hair follicle.	DSC2 DSC3	2.40e-05	3	99	2	9810708
Pubmed	Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development.	DSC2 DSC3	2.40e-05	3	99	2	9389456
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	MAML1 E2F7 ZDBF2 ITPRID2 UBN2 SF3B3 NFATC1 UBR5 PIK3C2B	4.76e-05	588	99	9	38580884
Pubmed	Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis.	PPARGC1B NFATC1	4.79e-05	4	99	2	38252822
Pubmed	PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations.	PPRC1 PPARGC1B	4.79e-05	4	99	2	17341490
Pubmed	A critical role for the EphA3 receptor tyrosine kinase in heart development.	NFATC1 EPHA3	4.79e-05	4	99	2	17046737
Pubmed	Plakoglobin as a regulator of desmocollin gene expression.	DSC2 DSC3	4.79e-05	4	99	2	23652796
Pubmed	IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.	MPL TET2	7.98e-05	5	99	2	20508616
Pubmed	Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.	DSC2 DSC3	7.98e-05	5	99	2	22438068
Pubmed	Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP).	DSC2 DSC3	7.98e-05	5	99	2	1889810
Pubmed	Nomenclature of the desmosomal cadherins.	DSC2 DSC3	7.98e-05	5	99	2	8486729
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	PLEKHH1 SLIT2 PPARGC1B	8.59e-05	30	99	3	39366945
Pubmed	Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.	CACNA1E EPHA3	1.19e-04	6	99	2	16910173
Pubmed	Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons.	POU4F2 SLIT2	1.19e-04	6	99	2	12051827
Pubmed	Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.	DSC2 DSC3	1.19e-04	6	99	2	9404003
Pubmed	Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18.	DSC2 DSC3	1.19e-04	6	99	2	7959727
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TET2 E2F7 ZDBF2 SF3B3 NFATC1 MED12	1.32e-04	272	99	6	31010829
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	MPL PLB1 POLR1A NBEA RETSAT PALB2 LRRC55 PPARGC1B HHAT EPHA3	1.33e-04	832	99	10	36724073
Pubmed	VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.	POU4F2 SLIT2	1.67e-04	7	99	2	28676569
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	COL16A1 PPARGC1B EPHA3	1.90e-04	39	99	3	25859222
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 ZDBF2 PALB2 TXNL1 UBR5 CAMSAP1 MED12	1.98e-04	418	99	7	34709266
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	COL16A1 DSC2 NBEAL1 SH3GL1 ZDBF2 WDR11 UBR5 CAMSAP1	2.24e-04	568	99	8	37774976
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	POLR1A SH3GL1 MYO18A UBN2 PRKRA SLIT2 RNF214 SF3B3 CAMSAP1	2.28e-04	724	99	9	36232890
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PDE3B DSC2 DSC3 MYO18A ITPRID2 VARS2 TXNL1 SF3B3 WDR11 UBR5 ERAP2 BAZ2A PYCR2	3.06e-04	1487	99	13	33957083
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ZDBF2 TXNL1 MAST4 UBR5 CAMSAP1	3.38e-04	209	99	5	36779422
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSC2 DSC3	3.56e-04	10	99	2	12724416
Pubmed	A role for primary cilia in aortic valve development and disease.	NFATC1 GLI3	3.56e-04	10	99	2	28556366
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS12 ADAMTS10	3.56e-04	10	99	2	11167130
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	PCDHA8 NBEA ZC4H2 TDRD1 PIK3C2B BAZ2A	3.67e-04	329	99	6	17474147
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	DIS3L2 E2F7 PCDHA13 ZDBF2 VARS2 ZC4H2 RNF214 SF3B3 UBR5 GLI3 ULK2 MED12	3.93e-04	1327	99	12	32694731
Pubmed	Foxd1 is required for proper formation of the optic chiasm.	POU4F2 SLIT2	4.34e-04	11	99	2	15509772
Pubmed	Molecular mechanisms controlling midline crossing by precerebellar neurons.	POU4F2 SLIT2	4.34e-04	11	99	2	18562598
Pubmed	Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.	MPL PDE3B	4.34e-04	11	99	2	22649097
Pubmed	Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.	PCDHA13 PCDHA8	4.34e-04	11	99	2	9655502
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	E2F7 VARS2 SF3B3 UBR5 ALDH1L2	4.36e-04	221	99	5	29991511
Pubmed	Ventral neural patterning in the absence of a Shh activity gradient from the floorplate.	GLI3 HHAT	5.20e-04	12	99	2	28891097
Pubmed	Defining desmosomal plakophilin-3 interactions.	DSC2 DSC3	5.20e-04	12	99	2	12707304
Pubmed	Proteins of the CNR family are multiple receptors for Reelin.	PCDHA13 PCDHA8	5.20e-04	12	99	2	10612399
Pubmed	Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.	POU4F2 GLI3	5.20e-04	12	99	2	18417110
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS12 ADAMTS10	5.20e-04	12	99	2	25770910
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	POLR1A WDR11 UBR5 GLI3 CDC25B	5.44e-04	232	99	5	25515538
Pubmed	Genomic analysis of mouse retinal development.	COL16A1 PBK UBN2 PRKRA SLIT2 TRAFD1 NFATC1 BAZ2A TWSG1 UBALD1	5.98e-04	1006	99	10	15226823
Pubmed	Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.	POU4F2 CDC25B	6.13e-04	13	99	2	18625210
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	DSC2 DSC3	6.13e-04	13	99	2	14673151
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	TET2 CECR2	6.13e-04	13	99	2	26989192
Pubmed	Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.	PALB2 CDC25B	7.14e-04	14	99	2	21254220
Pubmed	PRSS50 is a testis protease responsible for proper sperm tail formation and function.	TEX14 SEPTIN12	7.14e-04	14	99	2	33913480
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	NFATC1 GLI3	7.14e-04	14	99	2	32151560
Pubmed	Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification.	GLI3 HHAT	7.14e-04	14	99	2	24076664
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 PDE3B DSC2 SH3GL1 ITPRID2 MAST4 PIK3C2B CAMSAP1 CDC25B	7.96e-04	861	99	9	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 CECR2 MAML1 ZC4H2 SF3B3 MAST4 CARNS1	8.08e-04	529	99	7	14621295
Pubmed	Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.	DSC2 DSC3	8.22e-04	15	99	2	9847250
Pubmed	Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.	PCDHA13 PCDHA8	8.22e-04	15	99	2	15640798
Pubmed	Desmocollin 3 is required for pre-implantation development of the mouse embryo.	DSC2 DSC3	9.38e-04	16	99	2	16418220
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	DSC2 DSC3	9.38e-04	16	99	2	29913133
Pubmed	RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.	DSC2 DSC3	9.38e-04	16	99	2	30689641
Pubmed	Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	PALB2 GLI3	9.38e-04	16	99	2	20301753
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TET2 MAML1 UBN2 TXNL1 MED12	1.04e-03	268	99	5	33640491
Pubmed	Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.	PCDHA13 PCDHA8	1.06e-03	17	99	2	29911975
Pubmed	Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities.	GLI3 EPHA3	1.06e-03	17	99	2	19168674
Pubmed	Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.	NBEAL1 RNPEPL1 PALB2 CDC25B	1.08e-03	157	99	4	12466305
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	DSC2 DSC3 MYO18A ITPRID2 SF3B3	1.15e-03	274	99	5	34244482
Pubmed	CNR/Pcdhalpha family in subplate neurons, and developing cortical connectivity.	PCDHA13 PCDHA8	1.19e-03	18	99	2	15570159
Pubmed	Genomic organization of the family of CNR cadherin genes in mice and humans.	PCDHA13 PCDHA8	1.19e-03	18	99	2	10662547
Pubmed	Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.	PALB2 CDC25B	1.19e-03	18	99	2	19308021
Pubmed	Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells.	OVOL1 NFATC1	1.19e-03	18	99	2	24735878
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	NBEA SLIT2	1.19e-03	18	99	2	27984743
Pubmed	Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.	WDR11 GLI3	1.33e-03	19	99	2	37516749
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	DSC3 NBEAL1 NBEA WDR11 TRIM36	1.36e-03	285	99	5	34369648
Pubmed	Genetic dissection of the function of hindbrain axonal commissures.	POU4F2 SLIT2	1.47e-03	20	99	2	20231872
Pubmed	Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.	POU4F2 SLIT2	1.47e-03	20	99	2	20696379
Pubmed	WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.	WDR11 GLI3	1.47e-03	20	99	2	29263200
Pubmed	The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum.	SLIT2 EPHA3	1.47e-03	20	99	2	11748150
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	PRKRA ARSB	1.63e-03	21	99	2	26234751
Pubmed	CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.	CECR2 BAZ2A	1.63e-03	21	99	2	22154806
Pubmed	Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.	SLIT2 GLI3	1.63e-03	21	99	2	23396189
Pubmed	Pten coordinates retinal neurogenesis by regulating Notch signalling.	MAML1 POU4F2	1.79e-03	22	99	2	22258620
Pubmed	Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.	SLC16A9 GLI3	1.79e-03	22	99	2	24376456
Pubmed	Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.	TRAFD1 UBR5	1.79e-03	22	99	2	24981174
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	PBK SF3B3 UBR5 CAMSAP1	1.93e-03	184	99	4	32908313
Pubmed	Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.	ZC4H2 LRP1B	1.95e-03	23	99	2	20932654
Pubmed	Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.	PALB2 UBR5	1.95e-03	23	99	2	22038470
Pubmed	Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.	TDRD1 TRIM36	2.13e-03	24	99	2	24067652
Pubmed	Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.	PPARGC1B MED12	2.13e-03	24	99	2	25348719
Pubmed	Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.	PCDHA13 PCDHA8	2.13e-03	24	99	2	24698270
Pubmed	T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.	GLI3 EPHA3	2.31e-03	25	99	2	27046536
Pubmed	BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.	DSC2 NFATC1	2.31e-03	25	99	2	23271346
Pubmed	Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling.	SLIT2 GLI3	2.49e-03	26	99	2	35927240
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	CACNA1E LRP1B ALDH1L2 GLI3	2.56e-03	199	99	4	23382691
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE3B PIK3C2B	2.69e-03	27	99	2	11156964
Pubmed	BMP receptor 1b is required for axon guidance and cell survival in the developing retina.	POU4F2 SLIT2	2.69e-03	27	99	2	12654290
GeneFamily	Desmosomal cadherins	DSC2 DSC3	2.64e-04	7	65	2	1188
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 NBEA	4.51e-04	9	65	2	1230
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS10	2.09e-03	19	65	2	50
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	COL16A1 ADAMTS12 SLIT2 MAST4 GLI3 EPHA3	4.78e-06	194	99	6	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	COL16A1 ADAMTS12 SLIT2 MAST4 GLI3 EPHA3	4.92e-06	195	99	6	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CECR2 GLI3 MED12 TTLL13	3.38e-05	82	99	4	89aff8676f98e062d0e69b38c7184e51aa1a915e
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CECR2 GLI3 MED12 TTLL13	3.38e-05	82	99	4	6875a10abf1221b3dfd954c319b5e8e12fac1ff2
ToppCell	Substantia_nigra-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Igfbp2_(Igfbp2)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CECR2 GLI3 MED12 TTLL13	3.38e-05	82	99	4	259bb4ae0373d8352cb1c3bff08f66b89a298440
ToppCell	droplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CECR2 RGS22 ADAMTS12 ADAMTS10 PPARGC1B	3.58e-05	167	99	5	3c06894fc6177f3c204094719904da42f08b9af8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B LRP1B SLIT2 SSC4D TWSG1	3.79e-05	169	99	5	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN7 MAML1 PPARGC1B PIK3C2B TWSG1	4.24e-05	173	99	5	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN7 MAML1 PPARGC1B PIK3C2B TWSG1	4.24e-05	173	99	5	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 DSC3 ADAMTS12 SLIT2 EPHA3	4.47e-05	175	99	5	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	LA-11._Adipocyte\|LA / Chamber and Cluster_Paper	PDE3B RETSAT LRP1B ADAMTS12 PPARGC1B	5.53e-05	183	99	5	3f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	RGS22 SLIT2 ARSB ALDH1L2 EPHA3	5.68e-05	184	99	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	Differ-KC\|World / shred by cell class for mouse tongue	PLB1 DSC2 SLC16A9 ALDH1L2 RNF122	6.13e-05	187	99	5	08f70e5103c6dd96f439f0cceda878963d26850d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FBLN7 PDE3B FCRL3 MAST4 CDC25B	6.29e-05	188	99	5	9db3d3010cb8a1f3ee1cdccaf3cbaac3cf983fc5
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPFIBP2 ZDBF2 UBR5 EPDR1 EPHA3	6.29e-05	188	99	5	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPFIBP2 ZDBF2 UBR5 EPDR1 EPHA3	6.29e-05	188	99	5	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPFIBP2 ZDBF2 UBR5 EPDR1 EPHA3	6.29e-05	188	99	5	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	FBLN7 PDE3B FCRL3 MAST4 CDC25B	6.29e-05	188	99	5	72be6fe654f3a5f654d3b9680145bce7ae9b721d
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PBK E2F7 NBEA POU4F2 CDC25B	6.44e-05	189	99	5	815afad947ed77a8b03724bf78014799fed34f54
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NBEAL1 MAML1 TEX14 NFATC1 DNAAF1	6.61e-05	190	99	5	4d401b73c0e7eb38e95d0851a128bf12bb0d3a9f
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 LRRC55 SLIT2 GLI3 EPHA3	6.94e-05	192	99	5	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	Control-Endothelial-VE_Arterial\|Endothelial / Disease state, Lineage and Cell class	LRP1B RND1 MAST4 PIK3C2B RNF122	6.94e-05	192	99	5	7e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 LRRC55 SLIT2 GLI3 EPHA3	6.94e-05	192	99	5	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 LRRC55 SLIT2 GLI3 EPHA3	6.94e-05	192	99	5	ac1477433704573f95111eee6263b93668d2845e
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	COL16A1 ADAMTS10 SLIT2 GLI3 EPHA3	6.94e-05	192	99	5	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FBLN7 E2F7 MAST4 GLI3 HHAT	6.94e-05	192	99	5	d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	COL16A1 ADAMTS12 SLIT2 GLI3 EPHA3	7.29e-05	194	99	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG3 DSC3 ADAMTS12 ADAMTS10 SLIT2	7.47e-05	195	99	5	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL16A1 PBK E2F7 ADAMTS12 SLIT2	7.65e-05	196	99	5	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	T_cells-Treg_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	FBLN7 PDE3B ZDBF2 RNF214 FCRL3	7.84e-05	197	99	5	ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DSC3 SLCO6A1 OVOL1 GLI3 HHAT	7.84e-05	197	99	5	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LRP1B ADAMTS12 SLIT2 MAST4 GLI3	7.84e-05	197	99	5	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LRP1B ADAMTS12 SLIT2 MAST4 GLI3	7.84e-05	197	99	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	PDE3B COL16A1 ADAMTS12 SLIT2 EPHA3	7.84e-05	197	99	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	Control-Control-Lymphocyte-T/NK-Treg\|Control / Disease, condition lineage and cell class	FBLN7 PDE3B RNF214 MAST4 CDC25B	8.22e-05	199	99	5	6b7eb14bf03aa05f2d4ac4f5dd1ccf41a7e47bd1
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-Treg\|COVID-19_Mild / Disease, condition lineage and cell class	FBLN7 PDE3B FCRL3 MAST4 CDC25B	8.41e-05	200	99	5	c6ae15f7deba26008af5b647855675003bb2ebcd
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells-Neuroepithelial_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	PLB1 PBK E2F7 HHAT POC1B	8.41e-05	200	99	5	c9c832f489629b8724501ddfede984b41a7b674d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1E NBEA SLIT2 TRIM36 EPHA3	8.41e-05	200	99	5	306926cb7a847871641f02e03d52dc56fd55711c
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	NBEAL1 PPFIBP2 NBEA SLIT2 RND1	8.41e-05	200	99	5	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Stem_cells\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	PLB1 PBK E2F7 HHAT POC1B	8.41e-05	200	99	5	d7832ab1ed0ff0a6f7e3ac11b2095dc72c90af44
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL16A1 ADAMTS12 SLIT2 ALDH1L2 GLI3	8.41e-05	200	99	5	54806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	E2F7 TIPARP ZNF16 SOCS4 EPDR1	8.41e-05	200	99	5	fe772d98c461c973dfc082e1fc50117c27ced804
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1E PPFIBP2 NBEA PLEKHH1 ALDH1L2	8.41e-05	200	99	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PLEKHH1 TRIM36 CARNS1 TEX52	1.26e-04	115	99	4	15b2c11225802cc15c01165d84a755432f02d82f
Disease	Myelofibrosis	MPL TET2	6.39e-05	4	97	2	C0026987
Disease	arrhythmogenic right ventricular cardiomyopathy (implicated_via_orthology)	DSC2 DSC3	1.06e-04	5	97	2	DOID:0050431 (implicated_via_orthology)
Disease	desmocollin-2 measurement	DSC2 DSC3	1.06e-04	5	97	2	EFO_0021936
Disease	susceptibility to rheumatic fever measurement	TMEM114 MAML1 SLIT2	1.06e-04	28	97	3	EFO_0008416
Disease	Primary Myelofibrosis	MPL TET2	1.59e-04	6	97	2	C0001815
Disease	Polycythemia Vera	MPL TET2	2.96e-04	8	97	2	C0032463
Disease	mean arterial pressure, alcohol drinking	SLC16A9 GLI3 POC1B TRIM36	3.13e-04	98	97	4	EFO_0004329, EFO_0006340
Disease	propionylcarnitine measurement	SLC16A9 CARNS1	3.79e-04	9	97	2	EFO_0020942
Disease	Thrombocythemia, Essential	MPL TET2	6.91e-04	12	97	2	C0040028
Disease	vital capacity	TET2 DIS3L2 TMEM114 PCDHA13 PCDHA8 ADAMTS10 TXNL1 PIK3C2B GLI3 CARNS1 UBALD1 EPHA3	7.40e-04	1236	97	12	EFO_0004312
Disease	polyp of colon	PIK3C2B XRRA1 TTLL13	8.41e-04	56	97	3	MONDO_0021400
Disease	lysophosphatidylcholine 15:0 measurement	POU4F2 LRP1B	9.49e-04	14	97	2	EFO_0020941
Disease	gestational age	VARS2 SLIT2 ARSB UBR5	1.13e-03	138	97	4	EFO_0005112
Disease	MYELODYSPLASTIC SYNDROME	MPL TET2 PALB2	1.42e-03	67	97	3	C3463824
Disease	Epilepsy, Benign Psychomotor, Childhood	SLIT2 KCNC4	2.59e-03	23	97	2	C0393672
Disease	Epilepsy, Lateral Temporal	SLIT2 KCNC4	2.59e-03	23	97	2	C0393682
Disease	Uncinate Epilepsy	SLIT2 KCNC4	2.59e-03	23	97	2	C0014558
Disease	Epilepsy, Temporal Lobe	SLIT2 KCNC4	2.59e-03	23	97	2	C0014556
Disease	body weight	TET2 DIS3L2 COL16A1 POLR1A NBEAL1 E2F7 LRP1B ADAMTS10 SLIT2 MAST4 POC1B	2.87e-03	1261	97	11	EFO_0004338

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRNNLEAPPCKMTEP	TDRD1	11	Q9BXT4
MCNPRNYSDTPPTSK	TWSG1	76	Q9GZX9
PSVFTPPSTCQMAQL	EPDR1	201	Q9UM22
PSMSPLSPQDIFQLA	CACNA1E	1936	Q15878
CSSASSQPLGPRRPM	COL16A1	186	Q07092
SSKPMNRPSAANPCS	BAZ2A	1356	Q9UIF9
PFCTQFIPMDIIDSP	ALDH1L2	106	Q3SY69
PTRLPGFTETAACMP	CARNS1	631	A5YM72
VFSHQRPPPNMTLTC	ADGRG3	201	Q86Y34
PPPQTRMLSDLVEFC	DIS3L2	611	Q8IYB7
LNRTFTPIPCSEFPM	CAMSAP1	646	Q5T5Y3
PPPRSLFSDKNAMAS	CECR2	1251	Q9BXF3
PCSMLENSLGPFPLF	DSC2	141	Q02487
SPAAKPPATMRCNLR	ADAMTS10	986	Q9H324
QFLAGIPPPLSMSCN	ADAMTS12	1406	P58397
APLRFPAMNEPFTSC	NBEAL1	696	Q6ZS30
PPSPPDDFSCQMRLS	TIPARP	16	Q7Z3E1
VKTSPFQCERNPCPM	FBLN7	311	Q53RD9
SSCPRVFPQAGNLMP	MAML1	706	Q92585
SLMRPLQSSDCPLPK	SLC16A9	186	Q7RTY1
KTDLMAFSPCLPPDL	PCDHA8	766	Q9Y5H6
CSSQRLFSVPPDLPM	LRRC55	51	Q6ZSA7
VPRFSSLSSCNPPAM	GLI3	1021	P10071
APDMCVKFLCPSTRP	LRP1B	3706	Q9NZR2
VNCRSMSNKELFPPS	ARNTL2	551	Q8WYA1
LPISPFMDRSSPQLA	PDE3B	971	Q13370
PETFSSCLPFPMKEN	CSNKA2IP	526	A0A1B0GTH6
SQQLAMPPDPSSCLV	NFATC1	731	O95644
MHIQFPSKPTLPRAC	LRRC74A	1	Q0VAA2
QRPSSAPDLMCLSPD	CDC25B	226	P30305
TPSTPFSDLLMCPQH	MED12	341	Q93074
QCCTPAMLFPAPAAR	PGAP4	331	Q9BRR3
FLNPSLMSPECLPTT	POC1B	391	Q8TC44
ADNLSCPSPLNVMEP	ITPRID2	1056	P28290
ELFKQEMPPRCSSPT	PPFIBP2	351	Q8ND30
VAEPPSCPLALNMSL	OVOL1	51	O14753
ITSALNQLPPCPSRM	PIK3C2B	551	O00750
KTDLMAFSPSLPPCL	PCDHA13	766	Q9Y5I0
MEFSSPSREECPKPL	GBA	1	P04062
NDRPTTDMCSPAFPI	PALB2	716	Q86YC2
LTPPALPRCVSTMFS	HHAT	316	Q5VTY9
QMPTASLAEPLAFPS	PATL2	501	C9JE40
DSQRPGLMNPCQSSP	CCDC200	136	A0A1B0GVQ3
LPSNCEPVVSPSMFR	PCIF1	251	Q9H4Z3
GQLPSFSVPCMVLPS	E2F7	736	Q96AV8
PCSMQENSLGPFPLF	DSC3	141	Q14574
FRADKDPPSMACTRP	EPHA3	311	P29320
PMTLTCETQLSPQRP	FCRL3	206	Q96P31
MPFRKCSNPDVASGP	MAST4	131	O15021
DPNFVDSSPCPRNSM	ARSB	396	P15848
MPPTCQRDAAPLTSS	DNAAF1	661	Q8NEP3
PTQARMAFPCFDEPL	ERAP2	201	Q6P179
MEISPTQLCFLSPGP	C20orf173	26	Q96LM9
TPPEPSAKQRSMRCY	PPRC1	1391	Q5VV67
PCVMASLRAQSPIPN	RETSAT	546	Q6NUM9
LPQATGETFSMCIPP	VARS2	131	Q5ST30
PSFPIVAMENPCLTF	RNPEPL1	321	Q9HAU8
KQDSFLPCSRPPNSM	SERGEF	311	Q9UGK8
PTTNFRPKILMCPEH	TRIM36	201	Q9NQ86
PRSVPGFNPDSMCES	POLR1A	721	O95602
FPRMLPTLCDPGKQN	TEX14	826	Q8IWB6
PPGLDMPFCNTTEFR	SAXO1	261	Q8IYX7
TSCLPPSRPINNMTA	TRAFD1	446	O14545
FPQMATLLPLRPKSC	RGS22	541	Q8NE09
RTASMLCLNKPSPLP	RND1	181	Q92730
AMRRACLPTPPSNIF	POU4F2	86	Q12837
PPRSSAMHLCFLPQS	NBEA	2561	Q8NFP9
PRCLMLALSQSDPTF	PPARGC1B	571	Q86YN6
DPSACMFFEPLLSTP	SOCS4	366	Q8WXH5
PLSCFPNNMPGSTRI	SLCO6A1	331	Q86UG4
FQPAPKVIRCMTNTP	PYCR2	111	Q96C36
MPITCPTQNEPFLRT	PLB1	1036	Q6P1J6
QRPSIPCSGKMYLEP	C10orf82	211	Q8WW14
MPSADPRSLSFPILN	RNF214	476	Q8ND24
RSMPPLDQPSCKALY	SH3GL1	301	Q99961
LPLHSFPTMLKECSP	UBN2	696	Q6ZU65
KSCSMPPISFQDLPL	RNF122	21	Q9H9V4
LCDEFLPTQPPTRKM	SSC4D	156	Q8WTU2
PFLQMVQASESLPPS	TEX52	21	A6NCN8
MDPLRRSPSPCLSSQ	SEPTIN12	1	Q8IYM1
FEMNFQCAPPLPSDT	ZDBF2	1746	Q9HCK1
PMVLPRTSPCDNFDC	SLIT2	1116	O94813
SPCTPLMNPFRLENV	TMEM114	76	B3SHH9
LCSTPTINIPASPFM	PBK	21	Q96KB5
REKPRACPLSSQSMP	MPL	71	P40238
PSDCLQPLSMQALPA	SF3B3	621	Q15393
RESPPHQPCMKLLTF	PLEKHH1	261	Q9ULM0
ANASICFAVPDPLMP	PRKRA	101	O75569
SCRFASPPSLPDMQH	ULK2	301	Q8IYT8
RFSLSPNLMACQEIP	ZNF16	161	P17020
PPVFSKPMDSNIRQC	TRPV3	61	Q8NET8
SPCPQPLAFSSVETM	ZNF581	6	Q9P0T4
PQFAIRMCPPLTTKN	WDR11	466	Q9BZH6
SPSPMLSERPQNNCV	TET2	471	Q6N021
APTPPSLSQRVMCND	MYO18A	61	O95411
MPKRSCPFADVAPLQ	SIVA1	1	O15304
VFGTTPLPMACPALS	XRRA1	751	Q6P2D8
SDSMTFLGCIPPNPF	UBR5	2026	O95071
TPPNFPDALTMFSRL	UBALD1	71	Q8TB05
KVPLCPASAPMLQRS	TTLL13	791	A6NNM8
PCLRIAPAFSSMSNK	TXNL1	36	O43396
TATFRQQPPPMKACL	ZC4H2	176	Q9NQZ6
VPRPAQLESPMYCKS	KCNC4	496	Q03721