Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	SPHK2 GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR14A2 GPR174 PROKR2 OR2H2	3.37e-05	884	112	16	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	SPHK2 GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 LEPR NRP2 OR2T8 OR14A2 GPR174 PROKR2 LMBR1L PLXNA1 OR2H2	5.84e-05	1353	112	20	GO:0004888
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2	1.86e-04	4	112	2	GO:0005219
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIML1 TRIM75 TRIM26 RNF112 ZZEF1 TRIM7 TRIM28 LTN1 HLTF	4.09e-04	398	112	9	GO:0061659
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2	4.61e-04	6	112	2	GO:0048763
Domain	GPCR_Rhodpsn_7TM	GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 GPR174 PROKR2 OR2H2	4.32e-05	670	111	14	IPR017452
Domain	7tm_1	GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 GPR174 PROKR2 OR2H2	4.83e-05	677	111	14	PF00001
Domain	ConA-like_dom	TRIML1 TRIM26 RYR1 RYR2 TRIM7 NRP2 EYS PROS1	4.93e-05	219	111	8	IPR013320
Domain	G_PROTEIN_RECEP_F1_1	GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 GPR174 PROKR2 OR2H2	5.48e-05	685	111	14	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 GPR174 PROKR2 OR2H2	6.02e-05	691	111	14	PS50262
Domain	GPCR_Rhodpsn	GPR12 GPR20 OR2T33 HTR5A OR6K2 GPR84 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 GPR174 PROKR2 OR2H2	6.12e-05	692	111	14	IPR000276
Domain	Ryanodine_rcpt	RYR1 RYR2	1.05e-04	3	111	2	IPR003032
Domain	Ryanrecept_TM4-6	RYR1 RYR2	1.05e-04	3	111	2	IPR009460
Domain	RyR	RYR1 RYR2	1.05e-04	3	111	2	PF02026
Domain	RR_TM4-6	RYR1 RYR2	1.05e-04	3	111	2	PF06459
Domain	Ryan_recept	RYR1 RYR2	1.05e-04	3	111	2	IPR013333
Domain	SPRY	TRIML1 TRIM26 RYR1 RYR2 TRIM7	1.70e-04	87	111	5	SM00449
Domain	SPRY	TRIML1 TRIM26 RYR1 RYR2 TRIM7	2.44e-04	94	111	5	PF00622
Domain	SPRY_dom	TRIML1 TRIM26 RYR1 RYR2 TRIM7	2.44e-04	94	111	5	IPR003877
Domain	B30.2/SPRY	TRIML1 TRIM26 RYR1 RYR2 TRIM7	2.56e-04	95	111	5	IPR001870
Domain	B302_SPRY	TRIML1 TRIM26 RYR1 RYR2 TRIM7	2.56e-04	95	111	5	PS50188
Domain	RIH_assoc-dom	RYR1 RYR2	5.17e-04	6	111	2	IPR013662
Domain	Ins145_P3_rec	RYR1 RYR2	5.17e-04	6	111	2	PF08709
Domain	RIH_assoc	RYR1 RYR2	5.17e-04	6	111	2	PF08454
Domain	RIH_dom	RYR1 RYR2	5.17e-04	6	111	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2	5.17e-04	6	111	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2	5.17e-04	6	111	2	IPR015925
Domain	-	RYR1 RYR2	5.17e-04	6	111	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR2	5.17e-04	6	111	2	PF01365
Domain	MIR	RYR1 RYR2	1.53e-03	10	111	2	PF02815
Domain	Leu-rich_rpt_4	FLII NLRC5	1.53e-03	10	111	2	IPR025875
Domain	MIR_motif	RYR1 RYR2	1.53e-03	10	111	2	IPR016093
Domain	MIR	RYR1 RYR2	1.53e-03	10	111	2	PS50919
Domain	MIR	RYR1 RYR2	1.53e-03	10	111	2	SM00472
Domain	LRR_4	FLII NLRC5	1.53e-03	10	111	2	PF12799
Domain	ZF_RING_1	TRIML1 TRIM26 RNF112 TRIM7 TRIM28 LTN1 HLTF	1.77e-03	291	111	7	PS00518
Domain	Laminin_G_1	EYS PROS1	1.86e-03	11	111	2	PF00054
Domain	PRY	TRIML1 TRIM26 TRIM7	1.98e-03	42	111	3	PF13765
Domain	ZF_RING_2	TRIML1 TRIM26 RNF112 TRIM7 TRIM28 LTN1 HLTF	2.03e-03	298	111	7	PS50089
Domain	zf-C3HC4	TRIML1 TRIM26 RNF112 TRIM7 TRIM28 LTN1	2.17e-03	223	111	6	PF00097
Domain	RING	TRIML1 TRIM26 RNF112 TRIM7 TRIM28 LTN1 HLTF	2.31e-03	305	111	7	SM00184
Domain	Olfact_rcpt	OR2T33 OR6K2 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR2H2	2.40e-03	393	111	8	IPR000725
Domain	PRY	TRIML1 TRIM26 TRIM7	2.91e-03	48	111	3	SM00589
Domain	PRY	TRIML1 TRIM26 TRIM7	2.91e-03	48	111	3	IPR006574
Domain	Znf_RING	TRIML1 TRIM26 RNF112 TRIM7 TRIM28 LTN1 HLTF	3.34e-03	326	111	7	IPR001841
Domain	Znf_C3HC4_RING-type	TRIML1 TRIM26 RNF112 TRIM7 LTN1	3.65e-03	172	111	5	IPR018957
Domain	DUF1605	DHX36 DQX1	4.49e-03	17	111	2	IPR011709
Domain	HEAT_type_2	TEX10 MROH1	4.49e-03	17	111	2	IPR021133
Domain	OB_NTP_bind	DHX36 DQX1	4.49e-03	17	111	2	PF07717
Domain	CUB_dom	ADAMTS13 ZZEF1 NRP2	4.73e-03	57	111	3	IPR000859
Domain	HA2	DHX36 DQX1	5.03e-03	18	111	2	SM00847
Domain	HA2	DHX36 DQX1	5.03e-03	18	111	2	PF04408
Domain	Helicase-assoc_dom	DHX36 DQX1	5.03e-03	18	111	2	IPR007502
Domain	ARM-like	SMG1 APC2 TEX10 MROH1 LTN1 RIPOR1	5.52e-03	270	111	6	IPR011989
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2 DAGLA	5.79e-05	13	85	3	M39589
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII SPHK2 ZNF48 TRIO GRK6 OBSCN GEMIN5 ZZEF1 WDR59 RYR1 TRIM7 MROH1 PLEKHM2 TRIM28 NLRC5 RIPOR1 PLXNA1	1.09e-07	1105	113	17	35748872
Pubmed	Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.	DHX36 GEMIN5 MSH2 TRIM28 CDC25C	8.39e-07	53	113	5	36841324
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	TRIM26 MSH2 TEX10 GATAD2B TRIM28 SLX4	1.35e-06	106	113	6	19394292
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T33 OR6K2 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR14A2 OR2H2	1.80e-06	340	113	9	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T33 OR6K2 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR14A2 OR2H2	1.80e-06	340	113	9	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T33 OR6K2 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR14A2 OR2H2	1.93e-06	343	113	9	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T33 OR6K2 OR2J3 OR2T12 OR2H1 OR13J1 OR2T8 OR14A2 OR2H2	2.07e-06	346	113	9	14611657
Pubmed	The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.	DHX36 TRIM26 MSH2 TRIM28 HLTF	2.53e-06	66	113	5	32051553
Pubmed	Control of species-dependent cortico-motoneuronal connections underlying manual dexterity.	NRP2 SEMA6D PLXNA1	2.77e-06	9	113	3	28751609
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	KNTC1 FLII TRIO RNF112 GEMIN5 MSH2 LTN1	4.61e-06	202	113	7	33005030
Pubmed	Complex transcription and splicing of odorant receptor genes.	OR2J3 OR2H1 OR2H2	5.41e-06	11	113	3	12637542
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	NRP2 SEMA6D PLXNA1	7.19e-06	12	113	3	24179230
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR2J3 OR2H1 OR2H2	9.33e-06	13	113	3	14506126
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	1.05e-05	2	113	2	17259277
Pubmed	Hepsin enhances liver metabolism and inhibits adipocyte browning in mice.	LEPR HPN	1.05e-05	2	113	2	32404422
Pubmed	ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.	LEPR RYR1	1.05e-05	2	113	2	37468098
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	1.05e-05	2	113	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	1.05e-05	2	113	2	26009179
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	1.05e-05	2	113	2	32899693
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	1.05e-05	2	113	2	15033925
Pubmed	Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.	SEMA6D PLXNA1	1.05e-05	2	113	2	37344233
Pubmed	ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.	ZNF354C TRIM28	1.05e-05	2	113	2	33154469
Pubmed	G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds.	GPR84 LEPR	1.05e-05	2	113	2	38814782
Pubmed	Amelioration of Diabetes by Protein S.	LEPR PROS1	1.05e-05	2	113	2	27207541
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	1.05e-05	2	113	2	30542613
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	1.05e-05	2	113	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	1.05e-05	2	113	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	1.05e-05	2	113	2	11673462
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	1.05e-05	2	113	2	25370123
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	1.05e-05	2	113	2	18618700
Pubmed	Aire's partners in the molecular control of immunological tolerance.	NOP56 GEMIN5 MSH2 TRIM28	1.42e-05	45	113	4	20085707
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	RNGTT RNF112 OBSCN ZZEF1 ERLEC1 RYR1 IGSF10 DQX1 PKHD1 LRRC7 CFAP57	2.91e-05	736	113	11	29676528
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2	3.13e-05	3	113	2	18403125
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2	3.13e-05	3	113	2	7876312
Pubmed	Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.	SEMA6D PLXNA1	3.13e-05	3	113	2	29777213
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	3.13e-05	3	113	2	24123915
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	3.13e-05	3	113	2	23278119
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2	3.13e-05	3	113	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2	3.13e-05	3	113	2	10788707
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2	3.13e-05	3	113	2	7621815
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2	3.13e-05	3	113	2	10473538
Pubmed	Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.	NRP2 PLXNA1	3.13e-05	3	113	2	34636164
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2	3.13e-05	3	113	2	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2	3.13e-05	3	113	2	9204703
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2	3.13e-05	3	113	2	21881589
Pubmed	Genetic architecture of human thinness compared to severe obesity.	PKHD1 PRDM6	3.13e-05	3	113	2	30677029
Pubmed	The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS.	MSH2 TRIM28	3.13e-05	3	113	2	18675275
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2	3.13e-05	3	113	2	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2	3.13e-05	3	113	2	9242641
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	3.13e-05	3	113	2	23454728
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2	3.13e-05	3	113	2	25239916
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2	3.13e-05	3	113	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2	3.13e-05	3	113	2	11159936
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	3.13e-05	3	113	2	9986730
Pubmed	The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.	PRSS8 HPN	3.13e-05	3	113	2	26673890
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2	3.13e-05	3	113	2	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2	3.13e-05	3	113	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2	3.13e-05	3	113	2	7635066
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	OR2T33 ZSWIM5 AADACL3 OBSCN OR2T12 GATAD2B IARS2 SH2D1B KCNC4 GLUL LRRC7 CFAP57 RASAL2	3.15e-05	1031	113	13	16710414
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX36 FLII NOP56 MYO9A GEMIN5 MSH2 TEX10 WDR59 TRIM28 LTN1 BYSL HLTF CSTF1 PLCG2 RASAL2	3.32e-05	1353	113	15	29467282
Pubmed	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.	MSH2 HLTF SLX4	4.92e-05	22	113	3	22902628
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	6.25e-05	4	113	2	23992453
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2	6.25e-05	4	113	2	23413940
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2	6.25e-05	4	113	2	9607712
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	6.25e-05	4	113	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	6.25e-05	4	113	2	11237759
Pubmed	Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.	SEMA6D PLXNA1	6.25e-05	4	113	2	16715077
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2	6.25e-05	4	113	2	23482488
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2	6.25e-05	4	113	2	18206662
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	6.25e-05	4	113	2	22504960
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2	6.25e-05	4	113	2	9384575
Pubmed	Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.	SEMA6D PLXNA1	6.25e-05	4	113	2	14977921
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	6.25e-05	4	113	2	27226555
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	FLII RNGTT TEX10 WDR59 CDC25C	9.42e-05	139	113	5	25476789
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	NRP2 SEMA6D PLXNA1	1.03e-04	28	113	3	18617019
Pubmed	A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.	HTR5A LEPR TPH2	1.03e-04	28	113	3	19737523
Pubmed	Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.	SEMA6D PLXNA1	1.04e-04	5	113	2	20512151
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	1.04e-04	5	113	2	9124414
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2	1.04e-04	5	113	2	23918386
Pubmed	Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.	GLUL BYSL	1.04e-04	5	113	2	26711351
Pubmed	Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.	PRSS8 HPN	1.04e-04	5	113	2	19911255
Pubmed	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.	TRIO NRP2	1.04e-04	5	113	2	18212043
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2	1.04e-04	5	113	2	19011160
Pubmed	Altered clock gene expression and vascular smooth muscle diurnal contractile variations in type 2 diabetic db/db mice.	LEPR CRY2	1.04e-04	5	113	2	22140039
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	1.04e-04	5	113	2	22939628
Pubmed	Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.	TRIM7 TRIM28	1.04e-04	5	113	2	21940674
Pubmed	Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis.	RYR1 TTC21B	1.04e-04	5	113	2	11818962
Pubmed	Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch Repair.	MSH2 HLTF	1.04e-04	5	113	2	35784486
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2	1.56e-04	6	113	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2	1.56e-04	6	113	2	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2	1.56e-04	6	113	2	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2	1.56e-04	6	113	2	14592808
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2	1.56e-04	6	113	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2	1.56e-04	6	113	2	19009018
Pubmed	Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.	SEMA6D PLXNA1	1.56e-04	6	113	2	21831918
Pubmed	Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis.	NRP2 PLXNA1	1.56e-04	6	113	2	11442635
Pubmed	Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.	NRP2 PLXNA1	1.56e-04	6	113	2	19480842
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2	1.56e-04	6	113	2	20519450
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2	1.56e-04	6	113	2	16844763
Pubmed	SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair.	TRIM26 MSH2 SLX4	1.86e-04	34	113	3	31495888
Cytoband	1q44	OR2T33 OR2T12 OR2T8 OR14A2	1.64e-04	110	113	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T33 OR2T12 OR2T8 OR14A2	2.93e-04	128	113	4	chr1q44
GeneFamily	Olfactory receptors, family 2	OR2T33 OR2J3 OR2T12 OR2H1 OR2T8 OR2H2	1.43e-05	113	84	6	149
GeneFamily	Ring finger proteins	TRIML1 TRIM75 TRIM26 RNF112 TRIM7 TRIM28 LTN1 HLTF	4.15e-05	275	84	8	58
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2	6.38e-05	3	84	2	287
GeneFamily	G protein-coupled receptors, Class A orphans	GPR12 GPR20 GPR84 GPR174	4.76e-04	78	84	4	262
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM75 TRIM26 TRIM7 TRIM28	1.00e-03	95	84	4	59
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	GPR12 RYR1 TRIM28 CDC25C WWC1	1.55e-03	181	84	5	694
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPC2 GEMIN5 WDR59 GATAD2B NLRC5 CMTR2	4.82e-06	170	113	6	070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPR20 RBM20 RYR2 LRRC7 GRIP2 PRDM6	4.98e-06	171	113	6	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF410 NRP2 NEIL3 CDC25C SLX4 PLXNA1	6.90e-06	181	113	6	3fe648db1cb8326066d8bde3ca1287c5c9af19bd
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2	3.97e-05	3	108	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2	3.97e-05	3	108	2	DOID:8545 (implicated_via_orthology)
Disease	mitochondrial myopathy (implicated_via_orthology)	COX10 ADCK2	1.97e-04	6	108	2	DOID:699 (implicated_via_orthology)
Disease	Colorectal Carcinoma	HTR5A APC2 OBSCN MSH2 ITPRID1 TRIM28 PKHD1 ATP11C RASAL2 PROS1	2.60e-04	702	108	10	C0009402
Disease	Psychotic Disorders	HTR5A TPH2 GLUL WWC1	5.28e-04	101	108	4	C0033975
Disease	estrogen measurement	CRY2 DAGLA	5.86e-04	10	108	2	EFO_0011007
Disease	nucleus accumbens volume change measurement	ITPRID1 WWC1	7.14e-04	11	108	2	EFO_0021493
Disease	obesity (implicated_via_orthology)	FLII SPHK2 GPR12 LEPR GLUL	1.19e-03	215	108	5	DOID:9970 (implicated_via_orthology)
Disease	Cannabis use, age at onset	RYR2 LRRC7	2.18e-03	19	108	2	EFO_0004847, EFO_0007585
Disease	Familial aplasia of the vermis	TTC21B TCTN1	2.42e-03	20	108	2	cv:C0431399
Disease	Infiltrating duct carcinoma of female breast	SMG1 GRK6	2.66e-03	21	108	2	C3165106
Disease	Mood Disorders	HTR5A PROKR2 TPH2 GLUL	3.43e-03	168	108	4	C0525045

Protein segments in the cluster

Peptide	Gene	Start	Entry
CPLLRRCISVLETVV	TTC21B	471	Q7Z4L5
CLECGRTFTRIVTLI	ZNF354C	386	Q86Y25
TCEYEVVILTPLLCS	ERLEC1	231	Q96DZ1
CLTTLTVPRRCIGFA	EPC2	436	Q52LR7
DICDTLVVAVPSSLC	ADCK2	471	Q7Z695
ALVCVPVDVTDTLRC	CFAP54	1861	Q96N23
SREFRLLCCDIDPVL	BCDIN3D	101	Q7Z5W3
CLRDESTCSVVRPLT	GPR12	181	P47775
SRPCCRVFALTVLEF	GPR20	191	Q99678
SSDPLRTCAVLLCVG	CMTR2	676	Q8IYT2
ISPLLAVSFATCCAV	COX10	231	Q12887
TLCCVPTIFRLLVQE	ACSM5	316	Q6NUN0
LPETCIVSCEYDALR	AADACL3	336	Q5VUY0
SCSRLLVPLLDGTEC	ADAMTS13	346	Q76LX8
LSLEECLRLLEATCP	NFE2L1	251	Q14494
ICPETCLCVTTTLDL	RBM20	941	Q5T481
IFCDFLPVLRLACTD	OR6K2	176	Q8NGY2
SIPLVQLFACVSCDL	LTN1	1266	O94822
ICTQLLTLVAPECSV	MUC6	231	Q6W4X9
CSIASRIDCFSEVPT	NOP56	376	O00567
VCEVPALIRLSCEDT	OR2H2	176	O95918
FCEAPVLVRLACADT	OR2T12	176	Q8NG77
SCNDLTRVPECLYTL	FLII	231	Q13045
CGDEIRRITCLTPIF	EYS	1236	Q5T1H1
ACDACLTSRPIDSVL	NEIL3	336	Q8TAT5
ECPTTENTETFIRLC	RNGTT	96	O60942
ECTVCDPVTATETRL	ITPRID1	736	Q6ZRS4
AVLPCSESTTCLFRT	WWC1	701	Q8IX03
LVPCRCFRGEEEIIS	LRRC7	11	Q96NW7
VLCLCFSPSEETLVA	CFAP57	341	Q96MR6
ILPATCTLVNADRCT	DEFB114	16	Q30KQ6
IRILLEECTSTAFPD	FSIP2	3761	Q5CZC0
RFCSTVETPLPSERC	FAM124A	436	Q86V42
LVCGVREACVTPFLT	MFSD6L	21	Q8IWD5
PCTLTVSETQLLCEA	PLXNA1	1196	Q9UIW2
FCETPVLVRLACADT	OR2T8	176	A6NH00
RLELFGCRVTDAPCS	NRP2	421	O60462
ESLLSPCSTVECLDL	RASAL2	91	Q9UJF2
APCLFTDIRVLQDSC	LEPR	1106	P48357
TICSPDFLLDALELC	KNTC1	1141	P50748
ARKVVSCLSTCIFPD	GFUS	106	Q13630
SLLRVEPFVCAQCRT	GATAD2B	411	Q8WXI9
LGRSIACPFVEVEIC	PLCG2	1076	P16885
CLACVLFPLLRTSDD	GPR174	146	Q9BXC1
FCETPVLVRLACADT	OR2T33	176	Q8NG76
ILATILRVPSAARCC	OR13J1	221	Q8NGT2
LRCFTVLACSSPDRL	MROH1	336	Q8NDA8
VFLPSEEEISLCCES	DQX1	266	Q8TE96
LVPVVCTCSFDRIRG	GPR84	161	Q9NQS5
LLEVISVCDCPRGRF	HPN	131	P05981
TLLCLARVAVTCPTV	NLRC5	786	Q86WI3
LLLERDTSFTVCPDV	CDC25C	31	P30307
SREILSRCCALEPSL	DDO	251	Q99489
LRDLPREVCLCTSTV	PRDM6	241	Q9NQX0
VTLACELSPACAEVV	OBSCN	1826	Q5VST9
VFLCSSRCEELRAAP	APC2	2036	O95996
ATVLNVTCLSCLPRE	IGSF10	1056	Q6WRI0
VTCLSCLPRERLTTA	IGSF10	1061	Q6WRI0
LCLLASVPSCVEDLS	CRY2	516	Q49AN0
LFCCLDPVLTIAASL	DHX36	711	Q9H2U1
VYRELPCVSETLCDI	CARD8	71	Q9Y2G2
FFLTELISPLCSCDI	HTR5A	301	P47898
ILSVCITVLCVFDPT	DAGLA	146	Q9Y4D2
LTSPRSLEACARCAV	CCDC177	91	Q9NQR7
AICLDSLTVPVITHC	HLTF	761	Q14527
DYVLLPDERTISLCC	CSTF1	366	Q05048
TRDFDCCLAVPLLAE	GRIP2	996	Q9C0E4
CATRPELSRCVAFLD	GRK6	71	P43250
DVISCCLDLSVPSIS	RYR1	741	P21817
SCCLDLSAPSISFRI	RYR2	756	Q92736
PCESAEVSIVDCILA	MSH2	696	P43246
LIPLCESGTCTLREA	BYSL	291	Q13895
CIPCCLVLTDDRLFT	PLEKHM2	886	Q8IWE5
LCEVPSLIRLSCGDT	OR2H1	176	Q9GZK4
FCEVPALLRLSCVDT	OR2J3	181	O76001
FCDVPSLLRISCSET	OR14A2	176	Q96R54
CDPFSVTEALIRTCL	GLUL	346	P15104
SCLTEVESCFRLLVP	UVSSA	191	Q2YD98
CVCLLVLSSALPVFS	LMBR1L	396	Q6UX01
AVILSTFTTVPCLCL	PIGF	116	Q07326
DDCVPLLAITDATCV	TDRD12	736	Q587J7
EDCLIPLFSEALRSC	SMG1	1371	Q96Q15
SCLVLPLDVSLAFLC	PKHD1	1786	P08F94
ESSDTLCPRCAEVVS	IARS2	996	Q9NSE4
LEVPLISRETCNCLY	PRSS8	191	Q16651
SCEVVSVCLPLNLDT	PROS1	281	P07225
ALEISPRSCELFSII	SLX4	1181	Q8IY92
RDSESIPGVLCLCVS	SH2D1B	31	O14796
CRTVEDVLTPLEDCF	CNNM3	311	Q8NE01
ETFPCDLILLSSCTT	ATP11C	156	Q8NB49
PITRACCDDIAAALI	NLRP9	896	Q7RTR0
CPECDRTFSLSSTLL	ZNF48	361	Q96MX3
LDPIDCLFLTLTEAC	ZSWIM5	606	Q9P217
EATCSICLELFREPV	TRIM7	26	Q9C029
ICLELFREPVSVECG	TRIM7	31	Q9C029
TCSICLERLRDPISL	RNF112	56	Q9ULX5
LVPLAEVSGCCTLRS	SPHK2	91	Q9NRA0
ITCLSLLPVTEASEC	ZNF410	36	Q86VK4
CSICLDYLSDPVTIE	TRIM75	16	A6NK02
HLFIEPRTIFCLTCS	GEMIN5	146	Q8TEQ6
VTDVAVLCVCDLSPA	TCTN1	71	Q2MV58
TCVVSETLLPFLASC	TEX10	786	Q9NXF1
AISDFLVAIICCPFE	PROKR2	96	Q8NFJ6
PLRSLEEEVTCSICL	TRIM26	6	Q12899
CSICLDYLRDPVTID	TRIM26	16	Q12899
DPKTTCLQECLITTF	TPH2	401	Q8IWU9
CPEATTTELSLCRIT	TRIML1	261	Q8N9V2
EPCLRQLVSCLESFV	WDR59	481	Q6PJI9
VDSFLIRITSCCSTP	ZZEF1	456	O43149
IRITSCCSTPEVELT	ZZEF1	461	O43149
CCSTPEVELTLLAFA	ZZEF1	466	O43149
VLLVFVSTLCACPSS	TEX28	341	O15482
VAFSSCIIRIPLSRC	SEMA6D	501	Q8NFY4
RLSCFLCPVERVLLT	RIPOR1	981	Q6ZS17
RLISYLACIPSEEVC	TRIO	106	O75962
PLVLFCESCDTLTCR	TRIM28	216	Q13263
CEAVLACPLVETLVT	nan	126	Q6ZVH6
FLVRIVCCPDTLDFV	KCNC4	296	Q03721
IVFAPCILRCPDTTD	MYO9A	2211	B2RTY4