Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglycerophospholipid flippase activity

ATP11A ATP10A

1.25e-0414242GO:0140333
GeneOntologyMolecularFunctionfloppase activity

ATP11A ATP10A

1.64e-0416242GO:0140328
GeneOntologyMolecularFunctionflippase activity

ATP11A ATP10A

1.86e-0417242GO:0140327
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ATP11A ATP10A

5.13e-0428242GO:0140326
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ATP11A ATP10A

1.70e-0351242GO:0140303
GeneOntologyBiologicalProcessSRP-dependent cotranslational protein targeting to membrane, translocation

TRAM1L1 TRAM1

3.93e-058252GO:0006616
GeneOntologyCellularComponentphospholipid-translocating ATPase complex

ATP11A ATP10A

1.24e-0414252GO:1990531
GeneOntologyCellularComponentrough endoplasmic reticulum membrane

PI4KB RHO

5.47e-0429252GO:0030867
GeneOntologyCellularComponentendoplasmic reticulum membrane

ATP11A TRAM1L1 ATP10A TRAM1 PI4KB RYR1 RHO

6.10e-041293257GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

ATP11A TRAM1L1 ATP10A TRAM1 PI4KB RYR1 RHO

6.28e-041299257GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

ATP11A TRAM1L1 ATP10A TRAM1 PI4KB RYR1 RHO

7.13e-041327257GO:0042175
GeneOntologyCellularComponentrough endoplasmic reticulum

PI4KB RHO

2.65e-0364252GO:0005791
MousePhenoincreased skeletal muscle size

MSTN ZBED6

1.28e-0415162MP:0003398
MousePhenoabnormal skeletal muscle size

MSTN ZBED6 RYR1

1.50e-0493163MP:0009458
MousePhenoincreased hepatoma incidence

FAH FANCM

1.65e-0417162MP:0010264
DomainTranslocation_assoc_membrane

TRAM1L1 TRAM1

5.16e-063252IPR016447
DomainTRAM1

TRAM1L1 TRAM1

5.16e-063252PF08390
DomainTRAM1

TRAM1L1 TRAM1

5.16e-063252IPR013599
DomainP_typ_ATPase_c

ATP11A ATP10A

1.55e-0414252IPR032630
DomainP-type_ATPase_N

ATP11A ATP10A

1.55e-0414252IPR032631
DomainP-type_ATPase_IV

ATP11A ATP10A

1.55e-0414252IPR006539
DomainPhoLip_ATPase_C

ATP11A ATP10A

1.55e-0414252PF16212
DomainPhoLip_ATPase_N

ATP11A ATP10A

1.55e-0414252PF16209
DomainTLC

TRAM1L1 TRAM1

2.04e-0416252PS50922
DomainTRAM_LAG1_CLN8

TRAM1L1 TRAM1

2.04e-0416252PF03798
DomainTLC-dom

TRAM1L1 TRAM1

2.04e-0416252IPR006634
DomainTLC

TRAM1L1 TRAM1

2.04e-0416252SM00724
Domain-

ATP11A ATP10A

8.32e-04322522.70.150.10
Domain-

ATP11A ATP10A

8.32e-04322523.40.1110.10
DomainATPase_P-typ_cyto_domN

ATP11A ATP10A

9.96e-0435252IPR023299
DomainATPase_P-typ_P_site

ATP11A ATP10A

1.05e-0336252IPR018303
DomainP_typ_ATPase

ATP11A ATP10A

1.05e-0336252IPR001757
DomainATPASE_E1_E2

ATP11A ATP10A

1.05e-0336252PS00154
DomainATPase_P-typ_transduc_dom_A

ATP11A ATP10A

1.11e-0337252IPR008250
DomainE1-E2_ATPase

ATP11A ATP10A

1.11e-0337252PF00122
Domain-

ATP11A ATP10A

3.30e-03642523.40.50.1000
DomainHAD-like_dom

ATP11A ATP10A

4.98e-0379252IPR023214
Pubmed

ATPase reaction cycle of P4-ATPases affects their transport from the endoplasmic reticulum.

ATP11A ATP10A

5.37e-06526231571211
Pubmed

Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics.

ATP11A ATP10A

8.05e-06626225947375
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

USP34 BEND3 DTWD1 MED13L FANCM

1.92e-0545326529656893
Pubmed

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.

ATP11A ATP10A

3.53e-051226221914794
Pubmed

Differential expression of putative transbilayer amphipath transporters.

ATP11A ATP10A

4.17e-051326211015572
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

USP34 BEND3 CCDC88A ZBED6 PI4KB

2.45e-0477726535844135
GeneFamilyTLC domain containing

TRAM1L1 TRAM1

4.19e-05101821374
GeneFamilyATPase phospholipid transporting

ATP11A ATP10A

9.75e-05151821210
GeneFamilyWD repeat domain containing

NBEAL1 WDR87

2.75e-02262182362
Drugmag-indo-1

RYR1 RHO

2.62e-057262CID000131881
Drug[(2S)-2-[(Z)-dodec-9-enoyl]oxy-3-tetradecanoyloxypropyl] [(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl] phosphate

FAH SLC24A4 FANCM

4.33e-0560263CID011968289
DrugCefadroxil [50370-12-2]; Down 200; 11uM; HL60; HT_HG-U133A

USP34 ATP11A TRAM1 PI4KB

5.60e-051862641323_DN
DrugNSC-695672

TRAM1 RYR1 RHO

6.03e-0567263CID000393593
DrugAmodiaquin dihydrochloride dihydrate [6398-98-7]; Down 200; 8.6uM; HL60; HG-U133A

USP34 MED13L ATP10A PI4KB

6.86e-051962641570_DN
DrugDextromethorphan hydrobromide monohydrate [6700-34-1]; Down 200; 10.8uM; HL60; HT_HG-U133A

USP34 ATP11A CCDC88A PI4KB

7.28e-051992641281_DN
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; HL60; HG-U133A

USP34 ATP11A MED13L PI4KB

7.28e-051992641756_DN
DrugStachydrine hydrochloride; Down 200; 22.2uM; HL60; HG-U133A

USP34 CCDC88A MED13L ATP10A

7.28e-051992641751_DN
Diseasecutaneous melanoma, hair color

PTPN14 MED13L SLC24A4 ATP10A

2.55e-0762264EFO_0000389, EFO_0003924
Diseaseautosomal dominant nonsyndromic deafness (is_implicated_in)

ATP11A PI4KB

4.09e-0511262DOID:0050564 (is_implicated_in)
Diseaseidiopathic pulmonary fibrosis

ATP11A PTPN14

1.16e-0357262EFO_0000768
Diseasewhite matter hyperintensity measurement

CCDC88A NBEAL1 CC2D2B

2.32e-03302263EFO_0005665

Protein segments in the cluster

PeptideGeneStartEntry
FKVMFQQIFNIQLMY

CC2D2B

526

Q6DHV5
ANMVLYFFYKNTMFV

ATP10A

1086

O60312
YILIMKYNVKMQAFF

SLC24A4

241

Q8NFF2
KNMQLLQQMYQYLLF

NBEAL1

991

Q6ZS30
YNPVIYIMMNKQFRN

RHO

301

P08100
NIYFLIQKMFYMLNT

BEND3

191

Q5T5X7
YMLQTMKDEQVFYIQ

MED13L

1731

Q71F56
RFYVLYTIFMKGLQM

LETMD1

81

Q6P1Q0
YELLQQMGMRSLYFF

FANCM

371

Q8IYD8
IKFYYQETLQQLIMM

CCDC88A

86

Q3V6T2
MQELILMKFIYTSQY

FBXO31

266

Q5XUX0
LKKMYMEFPQLYNNS

GDE1

186

Q9NZC3
KSNFKYMYWTMLQQL

FAH

316

P16930
LANYMFFLMYLINKD

RYR1

4986

P21817
NLLFFYSFMYQLIKN

DTWD1

276

Q8N5C7
FSYMFILYTILQMNS

OR13C3

246

Q8NGS6
MPQILIFTYLNMFYF

OR10R2

1

Q8NGX6
MQKLQLCVYIYLFML

MSTN

1

O14793
MFMIQTIAQYKFVYQ

PTPN14

1161

Q15678
FNYYKMLMLQGLIAA

PI4KB

726

Q9UBF8
FLNYQRMYYVFIQML

ATP11A

1056

P98196
MTFQMKFFYISQLAY

TRAM1L1

161

Q8N609
LMFLKMNLKNVNYDY

ZBED6

941

P86452
MTFQMKFFYISQLAY

TRAM1

161

Q15629
LNMMKLFFDNLVYYI

USP34

951

Q70CQ2
MEQFYQLMDLYQLKS

WDR87

2751

Q6ZQQ6