Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

NCOA2 BCL9L NCOA3 ATN1 PPRC1 NACA BCL9 DHX9 SMARCC2

1.09e-05303929GO:0003713
GeneOntologyMolecularFunctiontranscription coregulator activity

NCOA2 BCL9L NCOA3 ATN1 PPRC1 NACA BCL9 DHX9 NCOR1 SMARCC2 CNOT2

5.45e-055629211GO:0003712
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

NCOA2 BCL9L NCOA3 SH3RF1 ATN1 PPRC1 NACA SH2D3C ICE1 BCL9 DHX9 NCOR1 ABI2 SMARCC2 CNOT2 GAB1

7.31e-0511609216GO:0030674
GeneOntologyMolecularFunctionmolecular adaptor activity

NCOA2 BCL9L NCOA3 SH3RF1 ATN1 PPRC1 NACA SH2D3C ICE1 BCL9 TAB3 DHX9 NCOR1 ABI2 SMARCC2 CNOT2 GAB1

1.36e-0413569217GO:0060090
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA2 NCOA3 NCOR1

5.11e-0434923GO:0046966
GeneOntologyMolecularFunctiontranscription factor binding

NCOA2 NCOA3 PPRC1 NACA GATA1 DHX9 NCOR1 PER3 ZNF296 PTPRN CNOT2

6.80e-047539211GO:0008134
GeneOntologyMolecularFunctionRNA polymerase II complex binding

NCOA3 DHX9 SCAF1

7.67e-0439923GO:0000993
GeneOntologyBiologicalProcesspositive regulation of Arp2/3 complex-mediated actin nucleation

WASF3 ABI2 WASF1

4.58e-068913GO:2000601
GeneOntologyBiologicalProcesspancreatic D cell differentiation

RFX6 ONECUT1

1.93e-052912GO:0003311
GeneOntologyBiologicalProcesspositive regulation of actin nucleation

WASF3 ABI2 WASF1

2.92e-0514913GO:0051127
GeneOntologyBiologicalProcessdevelopmental growth

NCOA3 EPPK1 ATN1 FOSL2 NACA PUM2 TNS2 BCL9 NCOR1 SLC12A2 TMEM108 PAX7 WASF1 AGRN

4.37e-059119114GO:0048589
GeneOntologyBiologicalProcessCOPII-coated vesicle cargo loading

SEC24A SEC31B SEC24C

6.46e-0518913GO:0090110
GeneOntologyBiologicalProcesscellular response to Thyroglobulin triiodothyronine

NCOA2 NCOR1

1.15e-044912GO:1904017
GeneOntologyCellularComponentSCAR complex

WASF3 ABI2 WASF1

1.71e-0512913GO:0031209
GeneOntologyCellularComponentbeta-catenin-TCF complex

BCL9L TCF7 BCL9

2.21e-0513913GO:1990907
GeneOntologyCellularComponentCOPII vesicle coat

SEC24A SEC31B SEC24C

4.29e-0516913GO:0030127
GeneOntologyCellularComponentendoplasmic reticulum exit site

SEC24A SEC31B SEC24C

8.10e-0442913GO:0070971
GeneOntologyCellularComponenthemidesmosome

EPPK1 ITGB4

1.00e-0311912GO:0030056
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

TNRC6B PUM2 KHSRP DHX9 MEX3B CNOT2

1.15e-03269916GO:0036464
GeneOntologyCellularComponenttranscription regulator complex

NCOA2 BCL9L NCOA3 TCF7 FOSL2 GATA1 BCL9 NCOR1 PAX7

1.15e-03596919GO:0005667
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NCOA2 BCL9L NCOA3 TCF7 FOSL2 BCL9

1.22e-03272916GO:0090575
GeneOntologyCellularComponentribonucleoprotein granule

TNRC6B PUM2 KHSRP DHX9 MEX3B CNOT2

1.60e-03287916GO:0035770
GeneOntologyCellularComponentchromatin

NCOA2 NCOA3 TCF7 FOXN4 FOSL2 GATA1 RFX6 ICE1 ONECUT1 DHX9 NCOR1 TPRX1 SMARCC2 PAX7 FOXK1

1.74e-0314809115GO:0000785
DomainPAS

NCOA2 NCOA3 PER3 KCNH2

1.71e-0532914SM00091
DomainPAS

NCOA2 NCOA3 PER3 KCNH2

2.19e-0534914IPR000014
DomainPAS

NCOA2 NCOA3 PER3 KCNH2

2.19e-0534914PS50112
DomainBCL9_beta-catenin-bd_dom

BCL9L BCL9

2.35e-052912IPR024670
DomainBCL9

BCL9L BCL9

2.35e-052912PF11502
DomainDUF4927

NCOA2 NCOA3

2.35e-052912PF16279
DomainDUF4927

NCOA2 NCOA3

2.35e-052912IPR032565
DomainBcl-9

BCL9L BCL9

2.35e-052912IPR015668
DomainDUF1518

NCOA2 NCOA3

7.02e-053912PF07469
DomainDUF1518

NCOA2 NCOA3

7.02e-053912IPR010011
DomainNuc_rcpt_coact_Ncoa-typ

NCOA2 NCOA3

7.02e-053912IPR014920
DomainSRC-1

NCOA2 NCOA3

7.02e-053912IPR014935
DomainSCAR/WAVE_fam

WASF3 WASF1

7.02e-053912IPR028288
DomainSrc1_rcpt_coact

NCOA2 NCOA3

7.02e-053912IPR008955
DomainNuclear_rcpt_coactivator

NCOA2 NCOA3

7.02e-053912IPR017426
DomainDUF1518

NCOA2 NCOA3

7.02e-053912SM01151
DomainSRC-1

NCOA2 NCOA3

7.02e-053912PF08832
Domain-

NCOA2 NCOA3

7.02e-0539124.10.630.10
DomainNuc_rec_co-act

NCOA2 NCOA3

7.02e-053912PF08815
DomainDUF1908

MAST2 MAST1

1.40e-044912PF08926
DomainMA_Ser/Thr_Kinase_dom

MAST2 MAST1

1.40e-044912IPR015022
DomainMAST_pre-PK_dom

MAST2 MAST1

1.40e-044912IPR023142
Domain-

MAST2 MAST1

1.40e-0449121.20.1480.20
DomainPAS

NCOA2 NCOA3 KCNH2

2.38e-0425913PF00989
DomainPAS_fold

NCOA2 NCOA3 KCNH2

2.38e-0425913IPR013767
DomainPAC

NCOA2 PER3 KCNH2

2.68e-0426913IPR001610
DomainPAC

NCOA2 PER3 KCNH2

2.68e-0426913SM00086
DomainSec23/24_helical_dom

SEC24A SEC24C

3.48e-046912IPR006900
DomainNuc_rcpt_coact

NCOA2 NCOA3

3.48e-046912IPR009110
DomainSec23_24_beta_S

SEC24A SEC24C

3.48e-046912IPR012990
Domainzf-Sec23_Sec24

SEC24A SEC24C

3.48e-046912PF04810
DomainSec23_trunk

SEC24A SEC24C

3.48e-046912PF04811
DomainSec23_helical

SEC24A SEC24C

3.48e-046912PF04815
DomainSec23_BS

SEC24A SEC24C

3.48e-046912PF08033
DomainSec23/24_trunk_dom

SEC24A SEC24C

3.48e-046912IPR006896
DomainZnf_Sec23_Sec24

SEC24A SEC24C

3.48e-046912IPR006895
Domain-

SEC24A COL22A1 ITGB4 SEC24C

4.68e-04749143.40.50.410
DomainVWF_A

SEC24A COL22A1 ITGB4 SEC24C

1.39e-0399914IPR002035
DomainGelsolin

SEC24A SEC24C

2.06e-0314912PF00626
DomainGelsolin-like_dom

SEC24A SEC24C

2.06e-0314912IPR007123
DomainWH2

WASF3 WASF1

2.06e-0314912SM00246
DomainWH2

WASF3 WASF1

2.70e-0316912PF02205
Domain-

FOXN4 RFX6 SMARCC2 PAX7 FOXK1

4.27e-032189151.10.10.10
DomainWH2_dom

WASF3 WASF1

4.64e-0321912IPR003124
PathwayBIOCARTA_ACTINY_PATHWAY

WASF3 ABI2 WASF1

1.05e-0510643MM1528
PathwayBIOCARTA_ACTINY_PATHWAY

WASF3 ABI2 WASF1

1.91e-0512643M7825
PathwayKEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION

SEC24A SEC31B SEC24C

1.91e-0512643M47770
Pubmed

Human transcription factor protein interaction networks.

NCOA2 CYLD BCL9L NCOA3 TCF7 ATN1 ATXN7L1 SOBP SEC24A NACA GATA1 TNRC6B PUM2 BCL9 TAB3 NCOR1 SMARCC2 PAX7 CNOT2 FOXK1

2.19e-091429972035140242
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA2 BCL9L NCOA3 ATN1 SOBP BCL9 NCOR1 TNRC18 TPRX1 SMARCC2 FOXK1

4.34e-09351971138297188
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

NCOA2 BCL9L NCOA3 ATN1 FOSL2 BCL9 NCOR1 TNRC18 SMARCC2 FOXK1

4.36e-09268971033640491
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NCOA2 BCL9L NCOA3 ATN1 SEC24A TNRC6B PUM2 BCL9 NCOR1 NUP155 CNOT2 FOXK1

5.97e-09457971232344865
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPPK1 SH3RF1 PPRC1 FOSL2 ICE1 BCL9 MAST2 DENND1A ITGB4 SCAF1 NCOR1 TNRC18 ZNF296 KCNH2 AGRN FOXK1 AGAP3

1.05e-081105971735748872
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

NCOA2 NCOA3 ATN1 SOBP TNRC6B PUM2 BCL9 TAB3

1.15e-0815297838360978
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CYLD SH3RF1 SEC24A IQSEC2 MAST2 DENND1A TAB3 STIM1 SLC12A2 MAP2K7 MEX3B FOXK1 GAB1 OTOG AGAP3

1.67e-08861971536931259
Pubmed

Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.

NCOA2 NCOA3 NCOR1

2.09e-07597310803578
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

EPPK1 ATN1 BCL9 NCOR1 TNRC18 SLC12A2 NUP155 PAX7 MEX3B GAB1

3.63e-07430971035044719
Pubmed

A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro.

NCOA2 NCOA3 NCOR1

4.18e-07697316373399
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NCOA2 CYLD NCOA3 PRR36 IQSEC2 TNRC6B BCL9 KHSRP NCOR1 SEC24C ABI2 SMARCC2 WASF1 AGRN

4.70e-07963971428671696
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CYLD BCL9L IQSEC2 NACA TNRC6B TAB3 KHSRP STIM1 TNRC18 ABI2 SMARCC2 LNPK WASF1 CNOT2 AGAP3

6.13e-071139971536417873
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

CCHCR1 ATN1 TNRC6B TNS2 ITGB4 SCAF1 NCOR1 PTPRN SMARCC2 AGRN ALG13

1.09e-06608971116713569
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

CYLD SEC24A TNRC6B DHX9 STIM1 NCOR1 SLC12A2 NUP155 SEC24C WASF1 GAB1 AGAP3

1.79e-06777971235844135
Pubmed

Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.

NCOA2 NCOA3 NCOR1

2.49e-061097315001550
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

BCL9L NCOA3 ATN1 NACA BCL9 DHX9 NCOR1 SEC24C SMARCC2

3.09e-0642597924999758
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

SH3RF1 IQSEC2 COL22A1 MAST2 DSCAML1 STIM1 NCOR1 TNRC18 TRIM50 FOXK1 OTOG

3.62e-06689971136543142
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA2 NCOA3 BCL9 NCOR1 FOXK1

3.72e-068397528794006
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

NCOA2 TCF7 SH3RF1 FOXN4 FOSL2 GATA1 OSR2 ONECUT1 PAX7 CNOT2 FOXK1

4.75e-06709971122988430
Pubmed

Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis.

NCOA2 NCOA3

7.70e-06297221220509
Pubmed

Uterine Tumor Resembling Ovarian Sex Cord Tumor: A Distinct Entity Characterized by Recurrent NCOA2/3 Gene Fusions.

NCOA2 NCOA3

7.70e-06297230273195
Pubmed

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.

BCL9L BCL9

7.70e-06297238811552
Pubmed

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

BCL9L BCL9

7.70e-06297215371335
Pubmed

A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells.

NCOA2 NCOA3

7.70e-06297230048685
Pubmed

Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice.

PAX7 AGRN

7.70e-06297238461287
Pubmed

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.

BCL9L BCL9

7.70e-06297220682801
Pubmed

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.

BCL9L BCL9

7.70e-06297233767438
Pubmed

Direct interactions between corepressors and coactivators permit the integration of nuclear receptor-mediated repression and activation.

NCOA3 NCOR1

7.70e-06297212089344
Pubmed

Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization.

WASF3 WASF1

7.70e-06297216190876
Pubmed

Effects of a Levonorgestrel-Releasing Intrauterine System on the Expression of Steroid Receptor Coregulators in Adenomyosis.

NCOA2 NCOA3

7.70e-06297226040939
Pubmed

The Association Between WAVE1 and -3 and the ARP2/3 Complex in PC 3 Cells.

WASF3 WASF1

7.70e-06297226977009
Pubmed

The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

BCL9 SEC31B TRIM50

1.15e-051697322792322
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

BCL9L NCOA3 BCL9 KHSRP NCOR1 NUP155

1.18e-0518097635198878
Pubmed

Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.

NCOA2 NCOA3 NCOR1

1.39e-051797319183483
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

NCOA2 NCOA3 TCF7 FOSL2 GATA1 ONECUT1 NCOR1 PER3 ZNF296 CNOT2 FOXK1

1.61e-05808971120412781
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

BCL9L FOSL2 NACA TNRC6B PUM2 ICE1 DENND1A SCAF1 SLC12A2 ABI2 FBXO28 AGRN CNOT2 FOXK1 AGAP3

1.68e-051497971531527615
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

NCOA2 FKBP10 EPPK1 WASF3 WASF1 MAP2K7 CNOT2 FOXK1 AGAP3

1.89e-0553397925544563
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CYLD PPRC1 FRMPD1 TNRC6B PUM2 SEC24C FBXO28 MAST1

1.91e-0540797812693553
Pubmed

The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles.

NCOA2 NCOA3

2.31e-05397221035760
Pubmed

Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors.

NCOA2 NCOR1

2.31e-05397224550004
Pubmed

Distinctive functions of p160 steroid receptor coactivators in proliferation of an estrogen-independent, tamoxifen-resistant breast cancer cell line.

NCOA2 NCOA3

2.31e-05397221059860
Pubmed

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.

MAST2 MAST1

2.31e-05397222101766
Pubmed

Prognostic value of novel biomarkers in astrocytic brain tumors: nuclear receptor co-regulators AIB1, TIF2, and PELP1 are associated with high tumor grade and worse patient prognosis.

NCOA2 NCOA3

2.31e-05397221735116
Pubmed

The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.

BCL9L BCL9

2.31e-05397234545187
Pubmed

Genomic organization and expression profile of the human and mouse WAVE gene family.

WASF3 WASF1

2.31e-05397212856283
Pubmed

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.

NCOA2 NCOA3

2.31e-05397216675958
Pubmed

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.

BCL9L BCL9

2.31e-05397233649334
Pubmed

FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors.

NCOA2 NCOA3

2.31e-05397215698540
Pubmed

Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

NCOA2 NCOA3

2.31e-0539729506940
Pubmed

Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers.

NCOA2 NCOA3

2.31e-05397228390937
Pubmed

Estrogen signaling in colorectal carcinoma microenvironment: expression of ERbeta1, AIB-1, and TIF-2 is upregulated in cancer-associated myofibroblasts and correlates with disease progression.

NCOA2 NCOA3

2.31e-05397219277704
Pubmed

Research resource: loss of the steroid receptor coactivators confers neurobehavioral consequences.

NCOA2 NCOA3

2.31e-05397223927929
Pubmed

Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.

NCOA2 NCOA3

2.31e-05397219052561
Pubmed

SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.

WASF3 WASF1

2.31e-0539729732292
Pubmed

WAVE/Scars in platelets.

WASF3 WASF1

2.31e-05397215280206
Pubmed

HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.

HUNK AGAP3

2.31e-05397238071109
Pubmed

Characterization of the WAVE1 knock-out mouse: implications for CNS development.

WASF3 WASF1

2.31e-05397212716942
Pubmed

Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder.

NCOA2 NCOA3

2.31e-05397218845648
Pubmed

The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.

NCOA2 NCOA3

2.31e-05397212138202
Pubmed

The nuclear receptor coactivators p300/CBP/cointegrator-associated protein (p/CIP) and transcription intermediary factor 2 (TIF2) differentially regulate PKA-stimulated transcriptional activity of steroidogenic factor 1.

NCOA2 NCOA3

2.31e-05397211923473
Pubmed

Structure and chromosomal locations of mouse steroid receptor coactivator gene family.

NCOA2 NCOA3

2.31e-05397210501088
Pubmed

Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.

BCL9L BCL9

2.31e-05397220637214
Pubmed

Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage.

WASF3 WASF1

2.31e-05397215670045
Pubmed

The genomic analysis of the impact of steroid receptor coactivators ablation on hepatic metabolism.

NCOA2 NCOA3

2.31e-05397216423883
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA2 NCOA3 NCOR1

2.32e-052097311877444
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

NCOA2 NCOA3 NCOR1

2.70e-052197319596656
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

SH3RF1 ATXN7L1 PUM2 MAST2 DSCAML1

3.30e-0513097512421765
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

CYLD SH3RF1 TNRC6B TAB3 MYO1F WASF1

3.48e-0521897633378226
Pubmed

Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.

NCOA2 NCOA3 NCOR1

3.58e-052397319737349
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DTNB SEC24A TNS2 TAB3 STIM1 NCOR1 SLC12A2 NUP155 PTPRN ABI2 WASF1 GAB1

3.60e-051049971227880917
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

CYLD BCL9L SH3RF1 TNRC6B MAST2 DENND1A AGAP3 ALG13

3.67e-0544697824255178
Pubmed

miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.

NCOA2 NCOA3

4.60e-05497226066330
Pubmed

Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.

ABI2 WASF1

4.60e-05497215143189
Pubmed

Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion.

WASF3 WASF1

4.60e-05497219200726
Pubmed

P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain.

NCOA2 NCOA3

4.60e-05497218267973
Pubmed

Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells.

NCOA2 NCOA3

4.60e-05497215331759
Pubmed

Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2.

NCOA2 NCOA3

4.60e-05497210598588
Pubmed

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.

WASF3 WASF1

4.60e-05497217664349
Pubmed

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

BCL9L BCL9

4.60e-05497219699733
Pubmed

The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.

SEC24A SEC24C

4.60e-05497232058034
Pubmed

Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells.

NCOA2 NCOA3

4.60e-05497219462000
Pubmed

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.

MAST2 MAST1

4.60e-05497215951562
Pubmed

Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity.

NCOA2 NCOA3

4.60e-05497219095746
Pubmed

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.

NCOA2 NCOA3

4.60e-05497212893883
Pubmed

Estrogen receptor alpha/beta, AIB1, and TIF2 in colorectal carcinogenesis: do coregulators have prognostic significance?

NCOA2 NCOA3

4.60e-05497219198856
Pubmed

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.

NCOA2 NCOA3

4.60e-05497222560224
Pubmed

Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite outgrowth.

TMEM108 WASF1

4.60e-05497227605705
Pubmed

Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain.

NCOA2 NCOA3

4.60e-05497211851396
Pubmed

Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.

NCOA2 NCOA3

4.60e-05497226267537
Pubmed

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.

NCOA3 NCOR1

4.60e-05497220003447
Pubmed

Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases.

MAST2 MAST1

4.60e-05497210404183
Pubmed

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.

NCOA2 NCOA3

4.60e-05497215563469
Pubmed

Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.

NCOA2 NCOA3

4.60e-05497215563453
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCOA3 ATN1 FOSL2 PUM2 BCL9 DHX9 SCAF1 NCOR1 SEC24C SMARCC2

6.19e-05774971015302935
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CYLD ATN1 ATXN7L1 TNRC6B C16orf96 MAST2 SCAF1 SMARCC2 MAP2K7 FOXK1 AGAP3 ALG13

6.52e-051116971231753913
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 ATXN7L1 SOBP DTNB FOSL2 WASF3 FRMPD1 TNRC6B DENND1A ADCY1 TNRC18 MAST1 C1orf159 AGAP3

6.58e-051489971428611215
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

NCOA2 NCOA3 NCOR1 SMARCC2

6.92e-057897428611094
Pubmed

Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.

NCOA2 NCOA3

7.66e-05597210652338
Pubmed

Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.

NCOA2 NCOA3

7.66e-05597217950690
Pubmed

SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm.

NCOA2 NCOA3

7.66e-05597217476305
InteractionYWHAH interactions

NCOA2 CYLD NCOA3 EPPK1 SH3RF1 SEC24A IQSEC2 TNS2 MAST2 DENND1A TAB3 STIM1 SLC12A2 ABI2 KCNH2 MAST1 WASF1 MEX3B FOXK1 GAB1 OTOG AGAP3

7.64e-0911029622int:YWHAH
InteractionTLE3 interactions

NCOA2 BCL9L NCOA3 ATN1 SEC24A GATA1 OSR2 BCL9 NCOR1 TNRC18 SMARCC2 PAX7 ALG13

2.69e-083769613int:TLE3
InteractionYWHAE interactions

CYLD SH3RF1 SEC24A IQSEC2 WASF3 TNS2 MAST2 DENND1A TAB3 DHX9 STIM1 ABI2 KCNH2 MAST1 SMARCC2 WASF1 AGRN MEX3B FOXK1 GAB1 OTOG AGAP3

7.90e-0812569622int:YWHAE
InteractionBCL9 interactions

BCL9L EPPK1 GATA1 BCL9 TIPARP PAX7 ALG13

1.76e-0786967int:BCL9
InteractionALG13 interactions

NCOA2 NCOA3 ATN1 TNRC6B PUM2 BCL9 NCOR1 MEX3B ALG13

2.27e-07183969int:ALG13
InteractionYWHAB interactions

CYLD SH3RF1 SEC24A IQSEC2 WASF3 TNS2 MAST2 DENND1A ITGB4 DHX9 STIM1 ABI2 MAST1 WASF1 MEX3B FOXK1 GAB1 OTOG AGAP3

2.57e-0710149619int:YWHAB
InteractionNUP35 interactions

NCOA2 BCL9L NCOA3 ATN1 SEC24A TNRC6B PUM2 BCL9 NCOR1 NUP155 CNOT2 FOXK1

8.17e-074249612int:NUP35
InteractionTOP3B interactions

EPPK1 SH3RF1 PPRC1 SEC24A FOSL2 TNRC6B ICE1 BCL9 MAST2 DENND1A ITGB4 DHX9 SCAF1 NCOR1 TNRC18 ZNF296 KCNH2 AGRN MEX3B CNOT2 FOXK1 AGAP3

1.17e-0614709622int:TOP3B
InteractionFMR1 interactions

NCOA2 CYLD NCOA3 IQSEC2 TNRC6B PUM2 BCL9 KHSRP DHX9 NCOR1 SMARCC2 MEX3B ALG13

1.55e-065369613int:FMR1
InteractionEYA4 interactions

NCOA2 NCOA3 ATN1 SOBP TNRC6B PUM2 BCL9 TAB3 NUP155

2.42e-06243969int:EYA4
InteractionPAX9 interactions

NCOA2 BCL9L NCOA3 ATN1 BCL9 NCOR1 FOXK1

2.92e-06130967int:PAX9
InteractionCRX interactions

NCOA2 BCL9L NCOA3 ATN1 TNS2 BCL9 TNRC18 ABI2 FOXK1

3.48e-06254969int:CRX
InteractionSNTB2 interactions

CYLD DTNB TNS2 MAST2 TIPARP PTPRN MAST1

5.50e-06143967int:SNTB2
InteractionSEC16A interactions

SEC24A TNRC6B TIPARP STIM1 NUP155 SEC24C LNPK MAP2K7 MEX3B CNOT2 ALG13

5.82e-064269611int:SEC16A
InteractionTNRC6B interactions

CYLD SEC24A TNRC6B PUM2 TIPARP NUP155 MEX3B CNOT2 ALG13

8.11e-06282969int:TNRC6B
InteractionSEC24A interactions

SEC24A TNRC6B TIPARP KHSRP STIM1 NUP155 SEC24C LNPK

1.18e-05224968int:SEC24A
InteractionYWHAZ interactions

CYLD SH3RF1 SEC24A IQSEC2 WASF3 SH2D3C MAST2 DENND1A TAB3 STIM1 NCOR1 EFNB3 ABI2 MAST1 WASF1 MEX3B FOXK1 GAB1 OTOG

1.24e-0513199619int:YWHAZ
InteractionTBR1 interactions

NCOA2 BCL9L NCOA3 BCL9 NCOR1 FOXK1

1.67e-05113966int:TBR1
InteractionEGR2 interactions

NCOA2 BCL9L NCOA3 ATN1 BCL9 NCOR1 TNRC18

1.77e-05171967int:EGR2
InteractionTBXT interactions

NCOA2 NCOA3 ATN1 BCL9 NCOR1 SMARCC2

1.94e-05116966int:TBXT
InteractionMXRA7 interactions

MAST2 STIM1 NUP155 MAST1 LNPK

2.24e-0571965int:MXRA7
InteractionNCOR2 interactions

NCOA3 GATA1 TIPARP NCOR1 PAX7 AGRN CNOT2 ALG13

3.82e-05264968int:NCOR2
InteractionTEKT3 interactions

ATN1 TNS2 RFX6 CNOT2

3.87e-0540964int:TEKT3
InteractionSRA1 interactions

SEC24A FOSL2 GATA1 DHX9 SEC24C

4.78e-0583965int:SRA1
InteractionTRIP6 interactions

CYLD ATN1 SH2D3C GATA1 TNS2 ITGB4 TIPARP ABI2 MEX3B

5.31e-05358969int:TRIP6
InteractionTNRC6A interactions

CYLD TNRC6B ITGB4 TIPARP NUP155 MEX3B CNOT2 ALG13

5.79e-05280968int:TNRC6A
InteractionNCOR1 interactions

NCOA3 TIPARP NCOR1 SEC24C SMARCC2 PAX7 CNOT2 FOXK1 ALG13

5.91e-05363969int:NCOR1
InteractionGSC interactions

BCL9L NCOA3 ATN1 BCL9 TNRC18

5.99e-0587965int:GSC
InteractionDCAF7 interactions

SEC24A TIPARP NCOR1 NUP155 SEC24C MAST1 PAX7 MAP2K7 FOXK1

6.56e-05368969int:DCAF7
InteractionAR interactions

NCOA2 BCL9L NCOA3 EPPK1 ATN1 FOSL2 SH2D3C BCL9 TIPARP KHSRP DHX9 NCOR1 TNRC18 SMARCC2 FOXK1

6.75e-059929615int:AR
InteractionPRAM1 interactions

SH3RF1 NCOR1 ABI2 MAST1

6.77e-0546964int:PRAM1
InteractionSMARCE1 interactions

NCOA2 CCHCR1 NCOA3 GATA1 HUNK TIPARP NCOR1 SMARCC2

6.88e-05287968int:SMARCE1
InteractionZNF609 interactions

CYLD ATN1 GATA1 TIPARP PAX7 ALG13

7.07e-05146966int:ZNF609
InteractionYWHAG interactions

CYLD SH3RF1 SEC24A DZIP1L IQSEC2 SH2D3C TNS2 MAST2 DENND1A TAB3 STIM1 WASF1 MEX3B FOXK1 GAB1 OTOG AGAP3

7.67e-0512489617int:YWHAG
InteractionJUN interactions

NCOA2 CYLD NCOA3 FOSL2 NACA KHSRP DHX9 NCOR1 SMARCC2 MAP2K7

8.14e-054709610int:JUN
InteractionMAGED1 interactions

CYLD GLYCTK GPR135 TNRC6B HUNK TIPARP AGRN MEX3B

8.34e-05295968int:MAGED1
InteractionFGFR1OP2 interactions

CCHCR1 ICE1 ABI2 FBXO28 LNPK

8.67e-0594965int:FGFR1OP2
InteractionFUBP3 interactions

GATA1 TNRC6B PUM2 TIPARP KHSRP MEX3B CNOT2 ALG13

8.74e-05297968int:FUBP3
InteractionNCOA3 interactions

NCOA2 NCOA3 TIPARP NCOR1 SMARCC2 PAX7 ALG13

9.84e-05224967int:NCOA3
InteractionUPF1 interactions

CYLD ATXN7L1 SEC24A TIPARP DHX9 STIM1 SEC24C MEX3B CNOT2 AGAP3 ALG13

1.00e-045819611int:UPF1
InteractionSP7 interactions

NCOA2 BCL9L NCOA3 ATN1 BCL9 NCOR1 SMARCC2 FOXK1

1.03e-04304968int:SP7
InteractionSS18L1 interactions

TCF7 ATN1 RFX6 SMARCC2 PAX7

1.06e-0498965int:SS18L1
InteractionLHX8 interactions

CCHCR1 FOSL2 BCL9 ABI2

1.18e-0453964int:LHX8
InteractionFOS interactions

NCOA2 CYLD NCOA3 NACA BCL9 KHSRP NCOR1 SMARCC2

1.23e-04312968int:FOS
InteractionYTHDF2 interactions

CYLD TNRC6B PUM2 TIPARP MAP2K7 MEX3B CNOT2 ALG13

1.23e-04312968int:YTHDF2
InteractionFBRS interactions

GATA1 TNRC6B TIPARP PAX7 ALG13

1.28e-04102965int:FBRS
InteractionRNF214 interactions

TNRC6B PUM2 TIPARP MEX3B CNOT2

1.40e-04104965int:RNF214
InteractionSMG7 interactions

NCOA2 NCOA3 TNRC6B BCL9 NCOR1 MEX3B CNOT2 ALG13

1.43e-04319968int:SMG7
InteractionLHX4 interactions

NCOA2 BCL9L BCL9 NCOR1 ABI2 FOXK1

1.43e-04166966int:LHX4
InteractionGARRE1 interactions

CYLD TNRC6B ABI2 MEX3B CNOT2 ALG13

1.48e-04167966int:GARRE1
InteractionSEC24B interactions

SEC24A TNRC6B TIPARP KHSRP STIM1 NUP155 SEC24C

1.51e-04240967int:SEC24B
InteractionSAR1A interactions

SEC24A KHSRP DHX9 STIM1 NCOR1 SELENOK NUP155 SEC24C

1.63e-04325968int:SAR1A
InteractionDTX2 interactions

BCL9L NCOA3 GLYCTK RFX6 BCL9 KHSRP NCOR1 NUP155

1.80e-04330968int:DTX2
InteractionTLX1 interactions

NCOA2 NCOA3 ATN1 BCL9 NCOR1 FOXK1

1.91e-04175966int:TLX1
InteractionUSP24 interactions

SH2D3C LNPK AGRN CNOT2 FOXK1

1.98e-04112965int:USP24
InteractionARID1B interactions

NCOA3 GATA1 TIPARP SMARCC2 PAX7 ALG13

2.03e-04177966int:ARID1B
InteractionCNOT2 interactions

CCHCR1 TNRC6B PUM2 NCOR1 MEX3B CNOT2

2.10e-04178966int:CNOT2
InteractionWASL interactions

SH3RF1 WASF3 TIPARP ABI2 WASF1

2.43e-04117965int:WASL
InteractionZNF688 interactions

GLYCTK TNS2 RFX6 FCHO1 ABI2

2.53e-04118965int:ZNF688
InteractionSSBP3 interactions

BCL9L DTNB BCL9 SMARCC2 PAX7

2.63e-04119965int:SSBP3
InteractionNFIA interactions

NCOA2 NCOA3 BCL9 DHX9 NCOR1 PAX7

2.81e-04188966int:NFIA
InteractionKRT31 interactions

CCHCR1 EPPK1 ATN1 ATXN7L1 DTNB ITGB4 ABI2 PRR19 ALG13

3.12e-04453969int:KRT31
InteractionGCM1 interactions

NCOA3 BCL9 NCOR1 SMARCC2

3.12e-0468964int:GCM1
InteractionMYOD1 interactions

NCOA2 NCOA3 BCL9 NCOR1 SMARCC2 PAX7

3.33e-04194966int:MYOD1
InteractionSPAG5 interactions

CCHCR1 ATN1 TNRC6B TIPARP ABI2 FBXO28

3.42e-04195966int:SPAG5
InteractionSLA interactions

NCOA2 ABI2 GAB1

3.50e-0429963int:SLA
InteractionFHL3 interactions

FOXN4 FOSL2 GATA1 TNS2 RFX6 TMEM108 FOXK1

3.53e-04276967int:FHL3
InteractionPRNP interactions

CYLD SH3RF1 IQSEC2 COL22A1 MAST2 DSCAML1 KHSRP STIM1 NCOR1 TNRC18 SLC12A2 TRIM50 FOXK1 OTOG AGAP3

3.66e-0411589615int:PRNP
InteractionFAM193A interactions

TNRC6B TIPARP MEX3B CNOT2

3.68e-0471964int:FAM193A
InteractionR3HDM2 interactions

TNRC6B PUM2 MEX3B CNOT2 ALG13

3.81e-04129965int:R3HDM2
InteractionARF1 interactions

SEC24A DENND1A KHSRP STIM1 NCOR1 SEC24C LNPK

4.02e-04282967int:ARF1
InteractionKRT27 interactions

CYLD CCHCR1 EPPK1 DTNB ABI2 SMARCC2

4.13e-04202966int:KRT27
InteractionCSDE1 interactions

CYLD TNRC6B TIPARP DHX9 SEC24C MEX3B ALG13

4.19e-04284967int:CSDE1
InteractionRABGEF1 interactions

CCHCR1 KHSRP DHX9 NCOR1 SEC24C ABI2

4.35e-04204966int:RABGEF1
InteractionNUP155 interactions

EPPK1 SH3RF1 SEC24A TNRC6B TNS2 TIPARP STIM1 NUP155 LNPK

4.53e-04477969int:NUP155
InteractionPLSCR4 interactions

GATA1 ITGB4 FCHO1 ALG13

4.54e-0475964int:PLSCR4
InteractionSCGN interactions

DTNB OSR2 ABI2 CNOT2

4.54e-0475964int:SCGN
InteractionSSPOP interactions

ATN1 ATXN7L1

4.64e-047962int:SSPOP
InteractionPCGF1 interactions

GATA1 FCHO1 TIPARP SMARCC2 PAX7 ALG13

4.82e-04208966int:PCGF1
InteractionERBB2 interactions

NCOA3 SEC24A SH2D3C TNS2 ITGB4 STIM1 NCOR1 SELENOK NUP155 GAB1

4.98e-045899610int:ERBB2
InteractionTNRC6C interactions

CYLD SEC24A TNRC6B MEX3B CNOT2

5.19e-04138965int:TNRC6C
InteractionPRRC2A interactions

CYLD ATN1 TNRC6B PUM2 TIPARP MEX3B CNOT2 ALG13

5.42e-04389968int:PRRC2A
InteractionPUM2 interactions

TNRC6B PUM2 MEX3B CNOT2 ALG13

6.30e-04144965int:PUM2
InteractionGPS2 interactions

TIPARP NCOR1 PAX7 CNOT2 FOXK1

6.30e-04144965int:GPS2
InteractionSOX7 interactions

NCOA2 NCOA3 TNRC18 SMARCC2

6.36e-0482964int:SOX7
InteractionTMEM214 interactions

TIPARP STIM1 NUP155 PTPRN LNPK

6.71e-04146965int:TMEM214
InteractionEFS interactions

SH2D3C NUP155 ABI2

7.24e-0437963int:EFS
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOA3 TNRC6B TNRC18

8.37e-0525623775
GeneFamilyWiskott-Aldrich Syndrome protein family

WASF3 WASF1

1.35e-031662214
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

OPHN1 AGAP3

1.52e-03176221291
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA2 NCOA3

1.52e-0317622486
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION_CCNE1

FOSL2 GATA1 DHX9 PER3

1.87e-0543964M11048
CoexpressionRIZ_ERYTHROID_DIFFERENTIATION_CCNE1

FOSL2 GATA1 DHX9 PER3

2.24e-0545964MM1107
CoexpressionGSE21033_CTRL_VS_POLYIC_STIM_DC_24H_UP

NCOA2 CYLD GATA1 SEC24C MYO1F TMEM108

2.49e-05157966M7731
CoexpressionKAYO_AGING_MUSCLE_UP

ATN1 GATA1 ONECUT1 KHSRP EFNB3 MYO1F MAST1

3.11e-05242967M16050
ToppCell390C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SOBP FOSL2 TNS2 TMEM121 DHX9 STIM1 TNRC18

1.02e-0717297784d16cd7f618c94888920680bdc9e7130d73fd75
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CD248 RFX6 PTPRN KCNH2 CCDC78

2.07e-05152975854c841c1fc6300b7e9be9c98cbf9b0ce2678690
ToppCell5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RFX6 ADCY1 DSCAML1 WDR97 MEX3B

2.81e-05162975478cf560ef33c5c324142c76417447d4a571a2c9
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYLD TCF7 GLYCTK FCHO1 DHX9

2.89e-051639754af92b211d12c5b88b65bb746242cd702b545bd0
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYLD TCF7 GLYCTK FCHO1 DHX9

2.89e-05163975d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated|Liver / Manually curated celltypes from each tissue

TCF7 CD248 BCL9 KCNH2 GAB1

3.15e-051669759afa33b5ad27dc33576be592f9b22d8161366838
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

FRMPD1 HUNK MEX3B FBN3 OTOG

3.44e-051699759c4e83fe8225d16173a103bf5a57b17d623be923
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

RFX6 COL22A1 DSCAML1 PTPRN KCNH2

3.44e-05169975b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell390C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FKBP10 SOBP TNS2 TNRC18 WDR97

3.63e-0517197570963f79711fe6088d6d01b29206b17ab89e5e73
ToppCellCV-Mild-6|Mild / Virus stimulation, Condition and Cluster

TNRC6B PUM2 FAM157B MAP2K7 ALG13

4.06e-05175975c4d530dbb37942427c9cd0a1533faeb6a3a45381
ToppCell10x5'-lymph-node_spleen-Hematopoietic_Erythro-Mega|lymph-node_spleen / Manually curated celltypes from each tissue

WASF3 GATA1 RIPOR3 PTPRN KCNH2

4.06e-051759755ca3369ce2c2bb88ba097260195aecd67cec1a3a
ToppCellwk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

RFX6 COL22A1 DSCAML1 PTPRN KCNH2

4.52e-0517997506f92c884189197c86793191c05f65e34925c097
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

RFX6 COL22A1 DSCAML1 PTPRN KCNH2

4.89e-0518297557bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellwk_15-18-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FRMPD1 RFX6 COL22A1 DSCAML1 PTPRN

5.02e-051839758820cfed27b292bc0bc9cde4005219ed41900552
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR135 HUNK TMEM121 PTPRN C1orf159

5.28e-05185975554c5d812197fbf66bf279fcc953277e926ade15
ToppCell(00)_Basal-(4)_1wkpi|(00)_Basal / shred by cell type and Timepoint

SH3RF1 TNS2 ITGB4 TIPARP PER3

5.28e-05185975bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

SH3RF1 SH2D3C RIPOR3 DSCAML1 SLC12A2

5.42e-05186975c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RFX6 COL22A1 DSCAML1 PTPRN KCNH2

5.42e-05186975b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

SH3RF1 SH2D3C RIPOR3 DSCAML1 SLC12A2

5.56e-05187975dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

SOBP WASF3 RIPOR3 ADCY1 OPHN1

5.99e-0519097512992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

FRMPD1 RFX6 ADCY1 DSCAML1 PTPRN

5.99e-05190975b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCellControl-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

NCOA2 SH2D3C FAM157C MYO1F FAM157A

6.46e-051939753479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal-mesenchymal_stem_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 CD248 WASF3 OSR2 TNS2

7.11e-051979753bb92dd8a94e2be3b7fe51c9a21b241215477ac7
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 CD248 WASF3 OSR2 TNS2

7.11e-0519797517344464fdcc5ba0c03959696b97c195f11e644c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-mesenchymal-mesenchymal|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FKBP10 CD248 WASF3 OSR2 TNS2

7.11e-051979755b8d0d7116b20d8e27541e88ec80c9f1f477e384
ToppCellSepsis-Bac-SEP-Myeloid-tDC|Bac-SEP / Disease, condition lineage and cell class

CCHCR1 TMEM121 PNPO TNRC18 ZNF296

7.46e-05199975a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 DTNB TNRC6B DENND1A OPHN1

7.46e-0519997594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

BCL9L ANO2 ZNF296 MYO1F MAP2K7

7.64e-052009750927061536a664b4f7feb9e5b0a8c11ca0d5955c
Drugretinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A

TCF7 FOSL2 TNS2 BCL9 ITGB4 ADCY1 KCNH2 SMARCC2

1.18e-061899485208_DN
DrugProbenecid [57-66-9]; Down 200; 14uM; PC3; HT_HG-U133A

ATN1 FRMPD1 TNRC6B ITGB4 KHSRP MYO1F AGRN GAB1

1.67e-061989484185_DN
DrugAtovaquone [95233-18-4]; Down 200; 11uM; PC3; HT_HG-U133A

ATN1 FRMPD1 TNS2 KHSRP STIM1 MYO1F AGRN

1.66e-051959474201_DN
DrugFoliosidine [2520-38-9]; Down 200; 13uM; MCF7; HT_HG-U133A

EPPK1 ATN1 MAST2 KHSRP STIM1 EFNB3 C1orf159

1.77e-051979474761_DN
DrugAcetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A

CYLD TCF7 EPPK1 ATN1 PRR36 IQSEC2 MAST2

1.77e-051979473364_DN
DrugIsometheptene mucate; Down 200; 8.2uM; HL60; HT_HG-U133A

NCOA2 FOSL2 IQSEC2 GPR135 FCHO1 C1orf159 AGRN

1.77e-051979473145_DN
DrugPseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; MCF7; HT_HG-U133A

CD248 PRR36 FOSL2 GPR135 BCL9 ONECUT1 FCHO1

1.77e-051979472766_UP
DrugMephenesin [59-47-2]; Up 200; 22uM; HL60; HT_HG-U133A

NCOA2 NCOA3 FOSL2 WASF3 FRMPD1 MAST2 AGRN

1.83e-051989472342_UP
DrugAG-028671 [847803-03-6]; Down 200; 10uM; MCF7; HT_HG-U133A

NCOA2 ATN1 PRR36 PPRC1 SEC24A STIM1 C1orf159

1.83e-051989476587_DN
Drug7,8-diaminopelargonic acid

ATN1 NCOR1 LNPK

2.40e-0514943CID000000652
Diseasepolycystic ovary syndrome (implicated_via_orthology)

NCOA2 NCOR1

1.53e-046952DOID:11612 (implicated_via_orthology)
DiseasePsychotic Disorders

SOBP BCL9 SLC12A2 KCNH2

3.24e-04101954C0033975
DiseaseC-C motif chemokine 25 measurement

MAP2K7 FBN3

3.64e-049952EFO_0008050
DiseaseSmall cell carcinoma of lung

COL22A1 ADCY1 KHSRP

7.12e-0454953C0149925
DiseaseAutosomal Dominant Myotubular Myopathy

STIM1 CCDC78

7.82e-0413952C3661489
DiseaseCentronuclear myopathy

STIM1 CCDC78

7.82e-0413952C0175709
DiseaseX-linked centronuclear myopathy

STIM1 CCDC78

7.82e-0413952C0410203
DiseaseCongenital Structural Myopathy

STIM1 CCDC78

7.82e-0413952C0752282
DiseaseMyopathy, Centronuclear, 1

STIM1 CCDC78

7.82e-0413952C4551952
DiseaseMyopathy, Centronuclear, Autosomal Dominant

STIM1 CCDC78

9.10e-0414952C1834558
Diseaseresponse to 5-fluorouracil, response to cyclophosphamide, chemotherapy-induced alopecia, response to doxorubicin

BCL9 DENND1A

9.10e-0414952EFO_0005400, GO_0036275, GO_1902518, GO_1902520
DiseaseTubular Aggregate Myopathy

STIM1 CCDC78

9.10e-0414952C0410207
DiseaseGlobal developmental delay

ATN1 PNPO SMARCC2 LNPK

9.15e-04133954C0557874
DiseaseGeneralized hypotonia

ATN1 LNPK

1.05e-0315952C1858120
DiseaseAutosomal Recessive Centronuclear Myopathy

STIM1 CCDC78

1.05e-0315952C3645536
DiseaseCongenital Fiber Type Disproportion

STIM1 CCDC78

1.52e-0318952C0546264
Diseasevital capacity

NCOA3 FRMPD1 C16orf96 NCOR1 MYO1F FAM157B FBN3 FOXK1 GAB1 OTOG AGAP3

2.08e-0312369511EFO_0004312
DiseaseEpilepsy, Cryptogenic

IQSEC2 SLC12A2 ALG13

2.38e-0382953C0086237
DiseaseAwakening Epilepsy

IQSEC2 SLC12A2 ALG13

2.38e-0382953C0751111
DiseaseAura

IQSEC2 SLC12A2 ALG13

2.38e-0382953C0236018
Diseasecolon adenocarcinoma (is_implicated_in)

GATA1 MAP2K7

3.17e-0326952DOID:234 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
SLPPGMQHPASGPAE

AGAP3

511

Q96P47
PTLPNHGGPSTMVPA

ALG13

746

Q9NP73
HAGSKSPTEPMPPRG

CD248

731

Q9HCU0
GAQPLPGHLPSPHAM

ATN1

321

P54259
MAGRSHPGPLRPLLP

AGRN

1

O00468
MATPGPRDIPLLPGS

ANO2

1

Q9NQ90
MGPPLGPARLNPHGS

FBN3

371

Q75N90
RHGSMCRPSPSPVSP

ATXN7L1

121

Q9ULK2
PPSPPMSGKGTLGRH

ABI2

181

Q9NYB9
MAGRPPSVGPVLSAP

RFX6

661

Q8HWS3
GPMPGSGPTKTPSFH

OPHN1

691

O60890
PIGMPLPSQTPGHSL

PUM2

621

Q8TB72
HGMRRPPPVNPGSVT

TIPARP

601

Q7Z3E1
HLLPGGFPPTGMPTL

PAX7

286

P23759
PQPLPPSTMHQGGLA

PAX7

326

P23759
LHGPSSTPPSSGPGM

DZIP1L

596

Q8IYY4
SLILPPGPGGTMKRH

FCHO1

386

O14526
LPARTSPMPGHPTAS

PTPRN

401

Q16849
PPAHMGFRSSPKTPP

GAB1

491

Q13480
LSQLPPSSSHMGGPP

IQSEC2

271

Q5JU85
LPPPPRHASTGAMHP

KCNH2

296

Q12809
LSMGLPPSRTPSHPT

PER3

1026

P56645
TTIPGAHSGPMRPLP

FAM157A

6

C9JC47
TPPARPRHMLGLPST

MAP2K7

66

O14733
PTSAGMVPINGLPPH

ONECUT1

236

Q9UBC0
TTIPGAHSGPMRPLP

FAM157C

6

P0CG43
LPTGDSPLGPMTHRG

PNPO

236

Q9NVS9
PAMRAPSHKGTPPTP

PRR25

121

Q96S07
MGSKALPAPIPLHPS

OSR2

1

Q8N2R0
MLSSQPPPHGDLGAP

ITGB4

1116

P16144
DPHGSSPLASPMSPR

MAST1

926

Q9Y2H9
GTPSHGIQPPAMSTP

NUP155

621

O75694
VLSGPVSHLMPFPGP

GATA1

371

P15976
VSHLMPFPGPLLGSP

GATA1

376

P15976
TTIPGAHSGPMRPLP

FAM157B

6

P0CG42
PMPGVSVRAGLPPHS

ADCY1

1091

Q08828
MFPAGPPSHSLLRLP

FKBP10

1

Q96AY3
PPMSSPHPGSLPSSF

ICE1

351

Q9Y2F5
PPRPPASMALLGSQH

GPR135

6

Q8IZ08
PGPMLHRALSLDPGG

GLYCTK

51

Q8IVS8
ASGPHLTMPARPPSL

C16orf96

1081

A6NNT2
PSTEPPRAGGPHTKM

DSCAML1

2006

Q8TD84
HPMAPLTSPPSAGSP

FRMPD1

1361

Q5SYB0
DIPLGTAPSMPGHNP

BCL9

1301

O00512
RLMGSPPVPGPSAAL

FBXO28

231

Q9NVF7
PGLPSGSMSPLHTPL

HUNK

601

P57058
RLSHMPLPPASNPPG

BCL9L

886

Q86UU0
SPHTSPTHGGGRPMP

DTNB

531

O60941
PTHGGGRPMPMPVRS

DTNB

536

O60941
PGLASVPGHMALPRP

FOSL2

86

P15408
SAPASPTHPGLMSPR

FOXK1

416

P85037
PTHPGLMSPRSGGLQ

FOXK1

421

P85037
MEHAATTGPRPGPPS

CCDC78

1

A2IDD5
MFPPSGSTGLIPPSH

CCHCR1

1

Q8TD31
PGTTSLFTPHPRMPG

COL22A1

851

Q8NFW1
ITLGPPRMESPSGPH

MAST2

1566

Q6P0Q8
MGTHTSPLQPLGPPA

DENND1A

901

Q8TEH3
ESPPLAMPPGNSHGL

CYLD

456

Q9NQC7
PMNRSSGTPGRPHPG

C1orf159

126

Q96HA4
ATSRGAEGPLPPPSM

EFNB3

211

Q15768
PRLPSMTGPLLPGQS

SEC24C

221

P53992
PLSMAPPLSLGLPGH

PPRC1

1031

Q5VV67
PTTMGGPLPPHLALK

DHX9

106

Q08211
MGSPASPQPHPLPSA

OTOG

1746

Q6ZRI0
TSCPRLSPPLHMAPG

MEX3B

436

Q6ZN04
SSQLGPIHPPPRTSM

KHSRP

131

Q92945
TPSPLLHGPAGMAPR

FOXN4

91

Q96NZ1
SPSPLPHPAMGRAPV

FOXN4

391

Q96NZ1
LGHIFMPPSPSTTPP

TAB3

316

Q8N5C8
VTPSLHSGPAPRMPL

SEC24A

96

O95486
GPTPGTPSPAMARRS

PRR36

166

Q9H6K5
TNMPPTILVPHPGGT

NCOR1

1656

O75376
TILVPHPGGTSTPPM

NCOR1

1661

O75376
MSGHTLPPLPVPGTN

EPPK1

1

P58107
LNMSSPPHGSPGLAP

NCOA3

461

Q9Y6Q9
PLRPLGPGRMVSHTP

SEC31B

941

Q9NQW1
GPGRMVSHTPAPPAS

SEC31B

946

Q9NQW1
LMELSPSAPPGGSPH

STIM1

596

Q13586
AESRPTPMGPPPTSH

SMARCC2

516

Q8TAQ2
HSLASPQPAPLMPGS

SH3RF1

626

Q7Z6J0
LHTPPSPSRGILPMN

CNOT2

121

Q9NZN8
LSPRHRMSPGVAGSP

NCOA2

486

Q15596
RINHLRGPSPPPMAG

SELENOK

76

Q9Y6D0
SVHGPPPPLLSGLAM

TNRC18

11

O15417
PILSPGRMRSPGSLP

TPRX1

286

Q8N7U7
PLPPGLLPEMAHLSG

RIPOR3

446

Q96MK2
SMPTAHRGSLAPPRG

PRR19

246

A6NJB7
LSPHIHPPSTPTMPG

SOBP

456

A7XYQ1
SHRKPPSSLGMTPAP

SCAF1

1136

Q9H7N4
GSALHPPPSPTGRLM

WDR97

236

A6NE52
HGPPGRPHMSSPTRD

TMEM121

301

Q9BTD3
MEPRPTAPSSGAPGL

SLC12A2

1

P55011
GPPGPGSSLSSSPMH

WASF3

406

Q9UPY6
SPMGSPHRASPMRTP

nan

96

Q9UF83
PSLMLGSGVPGHPAA

TCF7

216

P36402
PASPVSPSGPKGSHM

SH2D3C

341

Q8N5H7
HPTPSTAPGPHVPLM

WASF1

456

Q92558
RGSNSLPMVLPPPSG

TRIM50

461

Q86XT4
PPPPPMLSVSSDSGH

TNS2

501

Q63HR2
PHRMGSPAPLLPGDL

TNRC6B

1811

Q9UPQ9
PHHSPGPMPAGAALL

ZNF296

66

Q8WUU4
LPSGTPPGTMVTAPH

TMEM108

41

Q6UXF1
LPRHLGSPATSVPGM

LNPK

221

Q9C0E8
GSPATSVPGMGLHPP

LNPK

226

Q9C0E8
PLPLEIMSGGGTHRP

MYO1F

966

O00160
PPAATPSHKGGPAMT

NACA

1371

E9PAV3