Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	3.45e-07	431	57	10	GO:0004984
GeneOntologyMolecularFunction	methylumbelliferyl-acetate deacetylase activity	CES1 CES2	2.40e-05	3	57	2	GO:0047374
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	NPC1 OR2T3 TRPV1 FLT4 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	8.85e-05	1353	57	13	GO:0004888
GeneOntologyMolecularFunction	carboxylesterase activity	CES1 CES2	1.19e-04	6	57	2	GO:0106435
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	1.79e-04	884	57	10	GO:0004930
GeneOntologyMolecularFunction	retinyl-palmitate esterase activity	CES1 CES2	2.85e-04	9	57	2	GO:0050253
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC9A2 SLC38A5	9.36e-04	16	57	2	GO:0015385
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	TRPV1 RYR3	1.19e-03	18	57	2	GO:0015278
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	AGMO AHR PAM KDM4E	2.28e-03	194	57	4	GO:0016705
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC9A2 SLC38A5	2.68e-03	27	57	2	GO:0051139
GeneOntologyMolecularFunction	histone kinase activity	RPS6KA5 PRKAA2	2.89e-03	28	57	2	GO:0035173
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	7.55e-08	485	57	11	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	1.64e-07	524	57	11	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	2.52e-07	547	57	11	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	2.62e-07	432	57	10	GO:0050911
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	4.67e-07	582	57	11	GO:0050906
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	5.15e-07	465	57	10	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	3.81e-06	722	57	11	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR2T3 TRPV1 OR4K2 OR8D2 OR4C11 OR4C16 CDH23 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	2.95e-05	1072	57	12	GO:0007600
GeneOntologyBiologicalProcess	cholesterol metabolic process	NPC1 CES1 PRKAA2 CUBN PLPP6	8.71e-05	163	57	5	GO:0008203
GeneOntologyBiologicalProcess	response to xenobiotic stimulus	NPC1 PARP4 SULT1C3 PRKAA2 SERPINE1 AHR PAM CES2	9.22e-05	525	57	8	GO:0009410
GeneOntologyBiologicalProcess	negative regulation of systemic arterial blood pressure	ARHGAP42 TRPV1 AHR	9.38e-05	32	57	3	GO:0003085
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	NPC1 CES1 PRKAA2 CUBN PLPP6	1.25e-04	176	57	5	GO:1902652
GeneOntologyBiologicalProcess	sterol metabolic process	NPC1 CES1 PRKAA2 CUBN PLPP6	1.28e-04	177	57	5	GO:0016125
GeneOntologyBiologicalProcess	cellular response to xenobiotic stimulus	SULT1C3 PRKAA2 SERPINE1 AHR CES2	3.67e-04	222	57	5	GO:0071466
MousePheno	decreased abdominal fat pad weight	NPC1 TRPV1 KLF3	2.57e-06	10	40	3	MP:0009287
MousePheno	abnormal liver weight	NPC1 WARS1 CES1 AHR KLF3 CES2	4.80e-05	233	40	6	MP:0004847
Domain	Olfact_rcpt	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	2.72e-07	393	57	10	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	3.10e-05	670	57	10	IPR017452
Domain	7tm_1	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	3.39e-05	677	57	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	3.74e-05	685	57	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	4.03e-05	691	57	10	PS50262
Domain	GPCR_Rhodpsn	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	4.08e-05	692	57	10	IPR000276
Domain	Carboxylesterase_B_AS	CES1 CES2	2.53e-04	8	57	2	IPR019826
Domain	CARBOXYLESTERASE_B_1	CES1 CES2	2.53e-04	8	57	2	PS00122
Domain	I-BAR_dom	ARHGAP42 BAIAP2L2	6.99e-04	13	57	2	IPR013606
Domain	Carboxylesterase_B_CS	CES1 CES2	6.99e-04	13	57	2	IPR019819
Domain	CARBOXYLESTERASE_B_2	CES1 CES2	8.13e-04	14	57	2	PS00941
Domain	COesterase	CES1 CES2	8.13e-04	14	57	2	PF00135
Domain	CarbesteraseB	CES1 CES2	8.13e-04	14	57	2	IPR002018
Domain	BRCT	PARP4 TP53BP1	1.51e-03	19	57	2	PF00533
Domain	BRCT	PARP4 TP53BP1	2.03e-03	22	57	2	SM00292
Domain	-	PARP4 TP53BP1	2.22e-03	23	57	2	3.40.50.10190
Domain	BRCT	PARP4 TP53BP1	2.84e-03	26	57	2	PS50172
Domain	BRCT_dom	PARP4 TP53BP1	3.29e-03	28	57	2	IPR001357
Domain	BROMODOMAIN_1	BRPF3 BRD9	5.69e-03	37	57	2	PS00633
Domain	-	DPP10 CES1 CES2	5.75e-03	119	57	3	3.40.50.1820
Domain	AB_hydrolase	DPP10 CES1 CES2	5.75e-03	119	57	3	IPR029058
Domain	Bromodomain	BRPF3 BRD9	6.00e-03	38	57	2	PF00439
Domain	BROMODOMAIN_2	BRPF3 BRD9	6.95e-03	41	57	2	PS50014
Domain	BROMO	BRPF3 BRD9	7.29e-03	42	57	2	SM00297
Domain	Bromodomain	BRPF3 BRD9	7.29e-03	42	57	2	IPR001487
Domain	-	BRPF3 BRD9	7.29e-03	42	57	2	1.20.920.10
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	7.17e-07	389	49	10	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	1.35e-06	417	49	10	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T3 OR4K2 OR8D2 OR4C11 OR4C16 CDH23 OR13H1 OR2A5 OR2T10 OR2T34 OR8B8	8.79e-06	636	49	11	M41834
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR8B8	1.39e-06	340	57	7	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR8B8	1.39e-06	340	57	7	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR8B8	1.48e-06	343	57	7	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2A5 OR8B8	1.57e-06	346	57	7	14611657
Pubmed	Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.	CES1 CES2	2.64e-06	2	57	2	17537833
Pubmed	Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver.	CES1 CES2	2.64e-06	2	57	2	19487248
Pubmed	Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.	CES1 CES2	2.64e-06	2	57	2	18983829
Pubmed	Carboxylesterase in the liver and small intestine of experimental animals and human.	CES1 CES2	2.64e-06	2	57	2	17764701
Pubmed	Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.	CES1 CES2	2.64e-06	2	57	2	15475733
Pubmed	Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.	CES1 CES2	2.64e-06	2	57	2	24212379
Pubmed	Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes.	CES1 CES2	2.64e-06	2	57	2	18305377
Pubmed	Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.	CES1 CES2	2.64e-06	2	57	2	26825642
Pubmed	Pharmacogenomic assessment of carboxylesterases 1 and 2.	CES1 CES2	2.64e-06	2	57	2	15475243
Pubmed	Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor.	AHR SLC30A9	2.64e-06	2	57	2	16513642
Pubmed	Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans.	CES1 CES2	2.64e-06	2	57	2	28532270
Pubmed	Different inhibitory effects in rat and human carboxylesterases.	CES1 CES2	2.64e-06	2	57	2	19225040
Pubmed	Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.	CES1 CES2	2.64e-06	2	57	2	20649590
Pubmed	Examination of the carboxylesterase phenotype in human liver.	CES1 CES2	2.64e-06	2	57	2	22525521
Pubmed	The human olfactory receptor gene family.	OR4K2 OR8D2 OR4C11 OR4C16 OR13H1 OR2T10 OR2T34 OR8B8	2.75e-06	541	57	8	14983052
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	TRPV1 AHR CDH23	7.22e-06	23	57	3	34473953
Pubmed	High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma.	BRD9 CDH23	7.91e-06	3	57	2	32276436
Pubmed	Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.	CES1 CES2	7.91e-06	3	57	2	20195289
Pubmed	Human carboxylesterases: an update on CES1, CES2 and CES3.	CES1 CES2	7.91e-06	3	57	2	19508181
Pubmed	Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms.	CES1 CES2	7.91e-06	3	57	2	10452915
Pubmed	The Ah receptor recruits IKKα to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation.	RPS6KA5 AHR	1.58e-05	4	57	2	24519526
Pubmed	Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.	CES1 CES2	1.58e-05	4	57	2	18794728
Pubmed	Mammalian carboxylesterase 3: comparative genomics and proteomics.	CES1 CES2	2.63e-05	5	57	2	20422440
Pubmed	Nppb Neurons Are Sensors of Mast Cell-Induced Itch.	TRPV1 PAM	2.63e-05	5	57	2	30917312
Pubmed	Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.	NPC1 RRAGA	2.63e-05	5	57	2	28336668
Pubmed	Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.	AHR CDH23	2.63e-05	5	57	2	38496293
Pubmed	Differential effects of HTLV-1 Tax oncoprotein on the different estrogen-induced-ER α-mediated transcriptional activities.	AHR TP53BP1	3.94e-05	6	57	2	27420286
Pubmed	Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins.	CES1 CES2	3.94e-05	6	57	2	20931200
Pubmed	Lymphoangiocrine signals promote cardiac growth and repair.	RELN FLT4	5.51e-05	7	57	2	33299187
Pubmed	Low-dose metformin targets the lysosomal AMPK pathway through PEN2.	TRPV1 PRKAA2	5.51e-05	7	57	2	35197629
Pubmed	Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.	CES1 AHR	5.51e-05	7	57	2	2505256
Pubmed	Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1).	RRAGA PRKAA2	7.34e-05	8	57	2	23184942
Pubmed	Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.	RPS6KA5 NR4A3	7.34e-05	8	57	2	16223362
Pubmed	Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord.	RELN TRPV1	9.43e-05	9	57	2	16580148
Pubmed	The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.	TRPV1 PRKAA2	9.43e-05	9	57	2	36217034
Pubmed	Irinotecan pathway genotype analysis to predict pharmacokinetics.	CES1 CES2	1.18e-04	10	57	2	12960109
Pubmed	Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.	OR8D2 OR8B8	1.18e-04	10	57	2	11130974
Pubmed	Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.	RPS6KA5 PRKAA2	1.44e-04	11	57	2	11500364
Pubmed	WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.	PRKAA2 ATG2A	2.03e-04	13	57	2	28561066
Pubmed	A Combinatorial CRISPR-Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment.	FLT4 SERPINE1	2.03e-04	13	57	2	34666996
Pubmed	Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.	AHR CDH23	2.37e-04	14	57	2	38967302
Pubmed	Noradrenergic circuit control of non-REM sleep substates.	AHR CDH23	2.37e-04	14	57	2	34648731
Pubmed	Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.	AHR CDH23	2.37e-04	14	57	2	35665767
Pubmed	Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease.	AHR CDH23	2.37e-04	14	57	2	33688799
Pubmed	Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.	AHR CDH23	2.37e-04	14	57	2	24424947
Pubmed	Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.	RELN FLT4	2.37e-04	14	57	2	22665518
Pubmed	The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.	AHR CDH23	2.37e-04	14	57	2	36787309
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR8D2 OR4C11 OR4C16	2.49e-04	74	57	3	15081110
Pubmed	Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets.	AHR CDH23	2.73e-04	15	57	2	35719268
Pubmed	AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice.	AHR CDH23	2.73e-04	15	57	2	36873496
Pubmed	SnoN facilitates ALK1-Smad1/5 signaling during embryonic angiogenesis.	FLT4 SERPINE1	2.73e-04	15	57	2	24019535
Pubmed	Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons.	AHR CDH23	2.73e-04	15	57	2	38812551
Pubmed	Activation of neuronal Ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and axonal plasticity in mice.	AHR CDH23	2.73e-04	15	57	2	32964455
Pubmed	δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.	AHR CDH23	2.73e-04	15	57	2	37707499
Pubmed	Vascular-Derived Vegfa Promotes Cortical Interneuron Migration and Proximity to the Vasculature in the Developing Forebrain.	RELN FLT4	2.73e-04	15	57	2	29901792
Pubmed	Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.	AHR CDH23	2.73e-04	15	57	2	37883185
Pubmed	ERG K+ channels mediate a major component of action potential repolarization in lymphatic muscle.	AHR CDH23	2.73e-04	15	57	2	37689781
Pubmed	Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.	AHR CDH23	3.12e-04	16	57	2	36049479
Pubmed	Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.	AHR CDH23	3.12e-04	16	57	2	33904407
Pubmed	Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.	AHR CDH23	3.53e-04	17	57	2	30995469
Pubmed	The bone microenvironment invigorates metastatic seeds for further dissemination.	AHR CDH23	3.53e-04	17	57	2	33878291
Pubmed	Movement-related increases in subthalamic activity optimize locomotion.	AHR CDH23	3.53e-04	17	57	2	39068661
Pubmed	New GPCRs from a human lingual cDNA library.	OR8D2 OR8B8	3.53e-04	17	57	2	11705801
Pubmed	A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.	AHR CDH23	3.53e-04	17	57	2	37034992
Pubmed	Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.	AHR CDH23	3.97e-04	18	57	2	37914931
Pubmed	Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.	CES1 CES2	4.43e-04	19	57	2	12721789
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR13H1 OR2A5 OR2T34 OR8B8	4.65e-04	219	57	4	12213199
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	TRPV1 CES1	6.53e-04	23	57	2	29768498
Pubmed	Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.	CES1 CES2	1.11e-03	30	57	2	20529763
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	NPC1 RRAGA PRKAA2 ATG2A ZW10	1.41e-03	504	57	5	34432599
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR8D2 OR4C16	1.52e-03	35	57	2	16939646
Cytoband	1q44	OR2T3 OR2T10 OR2T34	3.75e-04	110	58	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T3 OR2T10 OR2T34	5.84e-04	128	58	3	chr1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4C11 OR4C16	1.19e-03	40	58	2	chr11q11
Cytoband	11q11	OR4C11 OR4C16	1.63e-03	47	58	2	11q11
Cytoband	11q24.2	OR8D2 OR8B8	2.92e-03	63	58	2	11q24.2
GeneFamily	Carboxylesterases	CES1 CES2	5.00e-05	5	41	2	461
GeneFamily	Olfactory receptors, family 2	OR2T3 OR2A5 OR2T10 OR2T34	1.23e-04	113	41	4	149
GeneFamily	Olfactory receptors, family 4	OR4K2 OR4C11 OR4C16	3.10e-03	129	41	3	151
Drug	Acridines	CES1 AHR CES2	5.17e-07	7	57	3	ctd:D000166
Drug	AC1M5V1J	CES1 CES2	6.16e-06	2	57	2	CID002385967
Drug	5-iodoisatin	CES1 CES2	6.16e-06	2	57	2	CID000088695
Drug	5-chloro-7-methylisatin	CES1 CES2	6.16e-06	2	57	2	CID000366710
Drug	I08-742	CES1 CES2	6.16e-06	2	57	2	CID002786143
Drug	3,3'-dimethoxybenzil	CES1 CES2	6.16e-06	2	57	2	CID000123493
Drug	tolserine	CES1 CES2	6.16e-06	2	57	2	ctd:C412047
Drug	NSC-379518	CES1 CES2	6.16e-06	2	57	2	CID000137905
Drug	DNC005462	CES1 CES2	6.16e-06	2	57	2	CID011437501
Drug	2-nitrophenylacetic acid	CES1 CES2	6.16e-06	2	57	2	ctd:C119971
Drug	aceanthrenequinone	CES1 CES2	6.16e-06	2	57	2	CID000316765
Drug	7-trifluoromethylisatin	CES1 CES2	6.16e-06	2	57	2	CID000604575
Drug	DNC005463	CES1 CES2	6.16e-06	2	57	2	CID011392969
Drug	5-chloroisatin	CES1 CES2	6.16e-06	2	57	2	CID000087203
Drug	AC1MS20N	CES1 CES2	6.16e-06	2	57	2	CID003527426
Drug	4-Chlorobenzil	CES1 CES2	6.16e-06	2	57	2	CID000089801
Drug	9-amino-6-chloro-2-methoxyacridine	CES1 CES2	6.16e-06	2	57	2	ctd:C010847
Drug	4,5-dichloro-1H-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID005139980
Drug	1,2-bis(4-nitrophenyl)ethane-1,2-dione	CES1 CES2	6.16e-06	2	57	2	CID001812008
Drug	p-methylbenzil	CES1 CES2	6.16e-06	2	57	2	CID000075511
Drug	AC1Q27R1	CES1 CES2	6.16e-06	2	57	2	CID000087502
Drug	4-amino-2,6-dimethylphenol	CES1 CES2	6.16e-06	2	57	2	CID000082667
Drug	2-chloro-3',4'-dimeth-oxy-benzil	CES1 CES2	6.16e-06	2	57	2	CID000092036
Drug	AC1M2MWF	CES1 CES2	6.16e-06	2	57	2	CID002147394
Drug	4,7-dichloroisatin	CES1 CES2	6.16e-06	2	57	2	CID002734793
Drug	4,6-dichloro-1h-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID000251908
Drug	d18-75	CES1 CES2	6.16e-06	2	57	2	CID000076996
Drug	AC1LWPKX	CES1 CES2	6.16e-06	2	57	2	CID001755771
Drug	AC1Q2DS8	CES1 CES2	6.16e-06	2	57	2	CID002427416
Drug	1,2-dicyclohexylethane-1,2-dione	CES1 CES2	6.16e-06	2	57	2	CID011806279
Drug	DP00565	CES1 CES2	6.16e-06	2	57	2	CID002777298
Drug	NSC 408976	CES1 CES2	6.16e-06	2	57	2	CID000101375
Drug	2,2'-Dichlorobenzil	CES1 CES2	6.16e-06	2	57	2	CID000089076
Drug	diethyl fluoromalonate	CES1 CES2	6.16e-06	2	57	2	CID000012702
Drug	anisil	CES1 CES2	6.16e-06	2	57	2	CID000071043
Drug	6-chloro-7-methyl-1H-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID004513067
Drug	5,7-dichloroisatin	CES1 CES2	6.16e-06	2	57	2	CID000080771
Drug	4-chloroisatin	CES1 CES2	6.16e-06	2	57	2	CID000096047
Drug	6-O-monoacetylmorphine	CES1 CES2	6.16e-06	2	57	2	ctd:C026979
Drug	p-methoxybenzil	CES1 CES2	6.16e-06	2	57	2	CID000031494
Drug	AC1N9FPX	CES1 CES2	6.16e-06	2	57	2	CID004384851
Drug	NNMP	CES1 CES2	6.16e-06	2	57	2	CID000146767
Drug	aniracetam	CES1 CES2	6.16e-06	2	57	2	ctd:C036466
Drug	AC1Q24Z2	CES1 CES2	6.16e-06	2	57	2	CID004338240
Drug	4-nitrobenzil	CES1 CES2	6.16e-06	2	57	2	CID000283893
Drug	1-benzyl-1h-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID000264734
Drug	prolyl-beta-naphthylamide	CES1 CES2	6.16e-06	2	57	2	CID000167505
Drug	chloroisatin	CES1 CES2	6.16e-06	2	57	2	CID000137777
Drug	5-(Trifluoro-meth-oxy)isatin	CES1 CES2	6.16e-06	2	57	2	CID002732752
Drug	4-chloro-7-methyl-1h-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID001810509
Drug	hostacain	CES1 CES2	6.16e-06	2	57	2	CID000022378
Drug	acetaldophosphamide	CES1 CES2	6.16e-06	2	57	2	CID000163905
Drug	phenethylcymserine	CES1 CES2	6.16e-06	2	57	2	ctd:C576198
Drug	4,4'-Difluorobenzil	CES1 CES2	6.16e-06	2	57	2	CID000123072
Drug	5,6-dichloro-1H-indole-2,3-dione	CES1 CES2	6.16e-06	2	57	2	CID011009341
Drug	4,4'-Dichlorobenzil	CES1 CES2	6.16e-06	2	57	2	CID000018946
Drug	4-nitrophenylacetic acid	CES1 CES2	6.16e-06	2	57	2	ctd:C118008
Drug	AC1MBV04	CES1 CES2	6.16e-06	2	57	2	CID002731732
Drug	1-laurylisatin	CES1 CES2	6.16e-06	2	57	2	CID001897797
Drug	1-cetylisatin	CES1 CES2	6.16e-06	2	57	2	CID003772674
Drug	AC1N4VNK	CES1 CES2	6.16e-06	2	57	2	CID004135273
Drug	Phenylmethylsulfonyl Fluoride	TRPV1 CES1 CES2	6.63e-06	15	57	3	ctd:D010664
Drug	ethyl chloride	CES1 SLC38A5 NR4A3 CES2	8.08e-06	51	57	4	CID000006337
Drug	methanesulfonate	SLC9A2 SLC38A5 PAM TP53BP1	1.26e-05	57	57	4	CID000006395
Drug	ethyl pentanoate	CES1 CES2	1.84e-05	3	57	2	CID000010882
Drug	1-(2-bromoethyl)-1H-indole-2,3-dione	CES1 CES2	1.84e-05	3	57	2	CID003542734
Drug	6-bromo-5-methyl-1H-indole-2,3-dione	CES1 CES2	1.84e-05	3	57	2	CID001718647
Drug	AC1MBTQK	CES1 CES2	1.84e-05	3	57	2	CID002731127
Drug	2-tridecanol	CES1 CES2	1.84e-05	3	57	2	CID000015449
Drug	indandione	CES1 CES2	1.84e-05	3	57	2	CID000123358
Drug	5'-deoxy-5-fluorocytidine	CES1 CES2	1.84e-05	3	57	2	ctd:C418208
Drug	diphenyl methyl phosphate	CES1 CES2	1.84e-05	3	57	2	CID000008291
Drug	5-bromoindoxyl acetate	CES1 CES2	1.84e-05	3	57	2	CID000087075
Drug	riboflavin-5'-monobutyrate	CES1 CES2	1.84e-05	3	57	2	CID000189057
Drug	tributyl phosphite	CES1 CES2	1.84e-05	3	57	2	CID000007623
Drug	2,2-dimethylpropyl methylphosphonofluoridate	CES1 CES2	1.84e-05	3	57	2	CID000574378
Drug	7-Chloro-indoline-2,3-dione	CES1 CES2	1.84e-05	3	57	2	CID000344135
Drug	AC1L7MWY	CES1 CES2	1.84e-05	3	57	2	CID000313189
Drug	bis(tBu-SATE)PMEA	CES1 CES2	1.84e-05	3	57	2	CID000464177
Drug	cyclohexyl hexadecanoate	CES1 CES2	1.84e-05	3	57	2	CID000074288
Drug	AC1Q2MLF	CES1 CES2	1.84e-05	3	57	2	CID002305233
Drug	1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine	CES1 CES2	1.84e-05	3	57	2	ctd:C122128
Drug	Methoxypropanol acetate	CES1 CES2	1.84e-05	3	57	2	CID003033863
Drug	AC1MBVDR	CES1 CES2	1.84e-05	3	57	2	CID002731902
Drug	AC1MBVDX	CES1 CES2	1.84e-05	3	57	2	CID002731904
Drug	5-bromisatin	CES1 CES2	1.84e-05	3	57	2	CID000006889
Drug	nordalbergin	CES1 CES2	1.84e-05	3	57	2	CID005320203
Drug	NACPC	CES1 CES2	1.84e-05	3	57	2	CID000175510
Drug	6-chloroisatin	CES1 CES2	1.84e-05	3	57	2	CID000241331
Drug	monomethyl adipate	CES1 CES2	1.84e-05	3	57	2	CID000012328
Drug	NSC-127077	CES1 CES2	1.84e-05	3	57	2	CID000277990
Drug	NNMBz	CES1 CES2	1.84e-05	3	57	2	CID000124353
Drug	AC1Q6FL6	CES1 CES2	1.84e-05	3	57	2	CID003821945
Drug	ACE co	CES1 CES2	1.84e-05	3	57	2	CID000163966
Drug	acetaldoifosphamide	CES1 CES2	1.84e-05	3	57	2	CID000131513
Drug	N-methylisatin	CES1 CES2	1.84e-05	3	57	2	CID000016358
Drug	AC1Q2IW1	CES1 CES2	1.84e-05	3	57	2	CID001713189
Drug	AC1MBV07	CES1 CES2	1.84e-05	3	57	2	CID002731733
Drug	AC1Q6FOF	CES1 CES2	1.84e-05	3	57	2	CID003114312
Drug	azinphos-methyl	CES1 CES2 AZIN1	2.90e-05	24	57	3	CID000002268
Disease	Atherogenesis	NPC1 TRPV1 SERPINE1 AHR	4.56e-06	59	55	4	C1563937
Disease	Atherosclerosis	NPC1 TRPV1 SERPINE1 AHR	4.56e-06	59	55	4	C0004153
Disease	Obesity	NPC1 TRPV1 CES1 SERPINE1 AHR	4.04e-05	205	55	5	C0028754
Disease	taste liking measurement	TRPV1 AHR PAM OR2A5 OR2T10 OR2T34	8.37e-05	388	55	6	EFO_0010155
Disease	Insulin Sensitivity	PRKAA2 AHR NR4A3	1.94e-04	60	55	3	C0920563
Disease	Insulin Resistance	PRKAA2 AHR NR4A3	1.94e-04	60	55	3	C0021655
Disease	Liver diseases	NPC1 SERPINE1 AHR	3.34e-04	72	55	3	C0023895
Disease	Liver Dysfunction	NPC1 SERPINE1 AHR	3.34e-04	72	55	3	C0086565
Disease	Behcet Syndrome	SERPINE1 AHR	9.17e-04	24	55	2	C0004943
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	DXO CES1 TP53BP1 CES2	1.10e-03	243	55	4	EFO_0004612, EFO_0020944
Disease	susceptibility to rheumatic fever measurement	RELN RYR3	1.25e-03	28	55	2	EFO_0008416
Disease	Cocaine-Related Disorders	RPS6KA5 CES1 CES2	1.37e-03	117	55	3	C0236736
Disease	Cocaine Abuse	RPS6KA5 CES1 CES2	1.73e-03	127	55	3	C0009171
Disease	primary dental caries	DPP10 CUBN	1.84e-03	34	55	2	EFO_0600095

Protein segments in the cluster

Peptide	Gene	Start	Entry
EMNSTMFDELTATYK	PPP2R5E	416	Q16537
ISQEFPYKSEMDSMP	AHR	681	P35869
TYMRTKSQDPMAIFF	ACSM6	211	Q6P461
MYEFQYRPSFSSDMK	CES1	446	P23141
VLEFMSMKSYPDVSV	BRD9	486	Q9H8M2
TSDSMMKNFFFVPSC	AZIN1	421	O14977
FRMLFYTMKPSETSF	AGMO	16	Q6ZNB7
QVISTPTDFFMVMEY	PRKAA2	81	P54646
YLEFISKPMDFSTMR	BRPF3	626	Q9ULD4
VTPKQSDTYFCMSMR	PAM	66	P19021
KTSYMMNVSATDQAP	CDH23	1276	Q9H251
FIDIMDMPNTNKYSF	CDH23	3111	Q9H251
MKEQCTYFDASFSPM	DPP10	471	Q8N608
PFSSKRTMYETEEMV	ATG2A	776	Q2TAZ0
KDSFFPMDDMFSVQS	RAD51AP2	861	Q09MP3
FCYSSVITPKMLMSF	OR8B8	71	Q15620
MSQTAMSETYDFLFK	RAB4A	1	P20338
ASLPEEKVSTFIMMY	RFX4	191	Q33E94
TFMYFKPPSSTTMEK	OR8D2	256	Q9GZM6
PVSVSYPSNYMESMK	KLF3	16	P57682
VVSQMKDPTFATFMY	LRRK1	1516	Q38SD2
GFTIYSLEMKMSFFE	GLB1L3	541	Q8NCI6
STMAIYKSIMEQFNP	BAIAP2L2	11	Q6UXY1
AVSFLLPMDMSSYSK	CCDC195	166	A0A1B0GUA6
MSLASFATPKMITDY	OR4K2	71	Q8NGD2
FLSQFNMTFPSDSMS	CES2	106	O00748
MTFYPTMEEFADFNT	KDM4E	16	B2RXH2
TNVARSAMMKDSPFY	RPS6KA5	406	O75582
DMMVSAFYTIFTPVL	OR2T34	276	Q8NGX1
SMYMKTQSKSYPDQD	OR13H1	256	Q8NG92
DMMVSAFYTIFTPVL	OR2T3	276	Q8NH03
TTFPMDKMVAVFYTI	OR4C11	261	Q6IEV9
TMSIEMPYVIEFIFS	PARP4	786	Q9UKK3
SSLKTFPTMKMFEYV	DXO	301	O77932
EMASQTFPMFISESF	RELN	701	P78509
TISFVPCTMQTFLYM	OR2A5	91	Q96R48
QTPEKDMMSSFFYTI	OR2T10	266	Q8NGZ9
MPDDSYMVDYFKSIS	NPC1	866	O15118
PYVMKTDSDMFVNTE	B3GALT2	246	O43825
VPVFYSSMSTAMVIF	CUBN	3361	O60494
TVFPMDKMIAVFYTV	OR4C16	261	Q8NGL9
SVPMMAQTNKFNYTE	SERPINE1	221	P05121
YTTEIMNPDYTKLTM	NR4A3	26	Q92570
MKDMYTFDSSPEAAQ	PARS2	206	Q7L3T8
KTFIFSDLDYMGMSS	WARS1	231	P23381
TSFDVMKQNPMTNYT	SULT1C3	236	Q6IMI6
YDKGSKTFTMSVSEM	ARHGAP42	291	A6NI28
SQMSYTVPIMAFAFV	SLC38A5	256	Q8WUX1
KAFVSTKMTSYMAID	CNK3/IPCEF1	456	G9CGD6
YFMKMLSSVSETLIF	SLC9A2	361	Q9UBY0
PSMKTLFVDSYSEML	TRPV1	501	Q8NER1
MNLGTDASTFKFYTM	RYR3	1201	Q15413
FTSNTYVMVVMSDPS	RRAGA	266	Q7L523
RMKTFEEFPMTPTTY	FLT4	1251	P35916
TSFKESYETQMNMLY	TEX11	901	Q8IYF3
MLSTSEYSQSPKMES	TP53BP1	516	Q12888
QMDMFVTLSVDKYSF	PLPP6	196	Q8IY26
MSFYKYVMESRDPST	SLC30A9	376	Q6PML9
MISKKYSEFLPSMQS	ZW10	41	O43264
ETMYFAPSMKDFTQY	NAF1	271	Q96HR8