Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein serine kinase activity

TNIK SMG1 MAST2 MAP3K5 CDC7 TESK2 ALPK3 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

1.98e-0536320114GO:0106310
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2B KMT2C KMT2D

5.42e-0582013GO:0140945
GeneOntologyMolecularFunctionmedium-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

1.01e-0422012GO:0140981
GeneOntologyMolecularFunction16-hydroxypalmitate dehydrogenase activity

CYP4A11 CYP4A22

1.01e-0422012GO:0103002
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2B KMT2C KMT2D

1.14e-04102013GO:0140999
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

TNIK SMG1 MAST2 MAP3K5 CDC7 TESK2 ALPK3 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

1.79e-0444620114GO:0004674
GeneOntologyMolecularFunctionprotein kinase activity

EPHB4 TNIK SMG1 MAST2 MAP3K5 CDC7 TESK2 ALPK3 FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

3.94e-0460020116GO:0004672
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

SMG1 PRKCB PRKD1

5.11e-04162013GO:0004697
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2B KMT2C PRDM8 KMT2D ANTKMT

6.13e-04682015GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2B KMT2C PRDM8 KMT2D ANTKMT

6.56e-04692015GO:0016278
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2B KMT2C PRDM8 ZCCHC4 KMT2D ANTKMT

6.80e-041052016GO:0008170
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2B KMT2C PRDM8 KMT2D ANTKMT

7.47e-04712015GO:0042054
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

EPHB4 TNIK SMG1 MAST2 MAP3K5 CDC7 TESK2 ALPK3 KHK FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

8.60e-0470920117GO:0016773
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2B KMT2C PRDM8 KMT2D

9.87e-04442014GO:0140938
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2B KMT2C KMT2D

1.01e-03202013GO:0042800
DomainFYrich_C

KMT2B KMT2C KMT2D

1.19e-0552003IPR003889
DomainFYrich_N

KMT2B KMT2C KMT2D

1.19e-0552003IPR003888
DomainFYRC

KMT2B KMT2C KMT2D

1.19e-0552003SM00542
DomainFYRN

KMT2B KMT2C KMT2D

1.19e-0552003SM00541
DomainFYRN

KMT2B KMT2C KMT2D

1.19e-0552003PF05964
DomainFYRC

KMT2B KMT2C KMT2D

1.19e-0552003PF05965
DomainFYRC

KMT2B KMT2C KMT2D

1.19e-0552003PS51543
DomainFYRN

KMT2B KMT2C KMT2D

1.19e-0552003PS51542
DomainMacrogloblnA2_thiol-ester-bond

CPAMD8 CD109 A2ML1

6.51e-0582003IPR019565
DomainThiol-ester_cl

CPAMD8 CD109 A2ML1

6.51e-0582003PF10569
DomainMacrogloblnA2_CS

CPAMD8 CD109 A2ML1

6.51e-0582003IPR019742
DomainA2M_N_2

CPAMD8 CD109 A2ML1

6.51e-0582003SM01359
Domain-

CPAMD8 CD109 A2ML1

6.51e-05820032.60.40.690
DomainA2M_recep

CPAMD8 CD109 A2ML1

6.51e-0582003SM01361
DomainA2M

CPAMD8 CD109 A2ML1

6.51e-0582003SM01360
DomainEPHD

KMT2B KDM4C KMT2C KMT2D

8.02e-05222004PS51805
Domain-

SAMD4B SAMD4A

1.14e-04220021.25.40.170
DomainPHAT_dom

SAMD4B SAMD4A

1.14e-0422002IPR015327
DomainA2M

CPAMD8 CD109 A2ML1

1.37e-04102003PF00207
DomainA2M_N_2

CPAMD8 CD109 A2ML1

1.37e-04102003IPR011625
DomainA2M_comp

CPAMD8 CD109 A2ML1

1.37e-04102003IPR011626
DomainA2M_recep

CPAMD8 CD109 A2ML1

1.37e-04102003PF07677
DomainA2M_comp

CPAMD8 CD109 A2ML1

1.37e-04102003PF07678
DomainA2M_N

CPAMD8 CD109 A2ML1

1.37e-04102003PF01835
DomainA2M_N

CPAMD8 CD109 A2ML1

1.37e-04102003IPR002890
DomainA-macroglobulin_rcpt-bd

CPAMD8 CD109 A2ML1

1.37e-04102003IPR009048
DomainALPHA_2_MACROGLOBULIN

CPAMD8 CD109 A2ML1

1.37e-04102003PS00477
DomainA2M_N_2

CPAMD8 CD109 A2ML1

1.37e-04102003PF07703
DomainMacroglobln_a2

CPAMD8 CD109 A2ML1

1.37e-04102003IPR001599
DomainPAC

KCNH8 NCOA2 KCNH4 EPAS1

1.59e-04262004IPR001610
DomainPAC

KCNH8 NCOA2 KCNH4 EPAS1

1.59e-04262004SM00086
DomainIg_I-set

MYOM1 DCC ALPK3 FGFR4 NRCAM DSCAM ICAM5 LINGO4 MDGA1

2.14e-041902009IPR013098
DomainI-set

MYOM1 DCC ALPK3 FGFR4 NRCAM DSCAM ICAM5 LINGO4 MDGA1

2.14e-041902009PF07679
DomainIGc2

MYOM1 DCC ALPK3 FGFR4 LILRA3 NRCAM DSCAM ICAM5 LINGO4 MDGA1

2.30e-0423520010SM00408
DomainIg_sub2

MYOM1 DCC ALPK3 FGFR4 LILRA3 NRCAM DSCAM ICAM5 LINGO4 MDGA1

2.30e-0423520010IPR003598
Domain-

CPAMD8 CD109 A2ML1

2.48e-041220031.50.10.20
DomainKinase-like_dom

EPHB4 TNIK SMG1 MAST2 MAP3K5 CDC7 TESK2 ALPK3 FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

2.52e-0454220016IPR011009
DomainK_chnl_volt-dep_ELK

KCNH8 KCNH4

3.40e-0432002IPR003950
DomainPROTEIN_KINASE_ATP

EPHB4 TNIK MAST2 MAP3K5 CDC7 TESK2 FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

4.45e-0445920014PS00107
DomainPAS

KCNH8 NCOA2 KCNH4 EPAS1

4.60e-04342004PS50112
DomainPAS

KCNH8 NCOA2 KCNH4 EPAS1

4.60e-04342004IPR000014
DomainPost-SET_dom

KMT2B KMT2C KMT2D

6.11e-04162003IPR003616
DomainPostSET

KMT2B KMT2C KMT2D

6.11e-04162003SM00508
DomainPOST_SET

KMT2B KMT2C KMT2D

6.11e-04162003PS50868
DomainProt_kinase_dom

EPHB4 TNIK MAST2 MAP3K5 CDC7 TESK2 FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

8.26e-0448920014IPR000719
DomainTerpenoid_cyclase/PrenylTrfase

CPAMD8 CD109 A2ML1

8.77e-04182003IPR008930
DomainIg_E-set

CPAMD8 CD109 NFATC1 NFATC2 A2ML1 ARHGDIG

8.89e-041042006IPR014756
DomainPROTEIN_KINASE_DOM

EPHB4 TNIK MAST2 MAP3K5 CDC7 TESK2 FGFR4 DMPK WNK4 WNK2 AATK PRKCB PRKD1 MAP3K13

8.94e-0449320014PS50011
DomainNFAT

NFATC1 NFATC2

1.12e-0352002IPR008366
DomainSET

KMT2B KMT2C PRDM8 KMT2D

1.46e-03462004SM00317
DomainOSR1_C

WNK4 WNK2

1.66e-0362002PF12202
DomainKinase_OSR1/WNK_CCT

WNK4 WNK2

1.66e-0362002IPR024678
DomainPAS_fold_3

KCNH8 KCNH4 EPAS1

1.83e-03232003IPR013655
DomainPAS_3

KCNH8 KCNH4 EPAS1

1.83e-03232003PF08447
DomainSET_dom

KMT2B KMT2C PRDM8 KMT2D

2.00e-03502004IPR001214
DomainSET

KMT2B KMT2C PRDM8 KMT2D

2.00e-03502004PS50280
DomainPAS-assoc_C

KCNH8 KCNH4 EPAS1

2.07e-03242003IPR000700
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

EPHB4 KMT2B KIAA0513 SIPA1L3 RAP1GAP2 KDM6B MAST2 REPIN1 ABCA7 ACOX3 MAP3K5 ESRP2 KMT2C TNRC18 NFATC1 TIGD3 ZC3H7B CRAMP1 WNK2 SEMA6B PLOD3 SH2B3 HIP1R GEMIN5 MLXIP FBXO46 NCOR2 KMT2D AATK DNAJC14 GAREM2 NAPRT SH3BP5L SYVN1

2.93e-1511052053435748872
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SMG1 SPAST ERMP1 KDM6B RGP1 STAB1 KMT2C ARID1B NRXN3 SULF1 ZC3H7B CRAMP1 WNK2 HIP1R TRIOBP NUDCD3 NUP93

1.98e-085292051714621295
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2B KDM4C KDM6B KMT2C KMT2D

1.28e-0721205527626377
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PHYKPL CPAMD8 UBE2K TRPC4AP KCNH8 PDE9A AIMP1 SIPA1L3 GAS6 BLNK KMT2C TNRC18 NFATC1 TGFBRAP1 CRAMP1 WNK2 NCOA2 TIGAR ANK3 SAMD4B TRIOBP NUDCD3 KIAA1671 NCOR2 GTF2I TJAP1 PRKD1

2.32e-0714892052728611215
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

ERMP1 SUCLG1 KMT2C ARID1B ALDH16A1 NONO NCOA2 TIGAR KHDC4 PCF11 NCOR2 KMT2D RAB34 NUP93

6.48e-074572051432344865
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2B KMT2C KMT2D

8.04e-074205319221051
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2B KMT2C KMT2D

8.04e-074205323129768
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2B KMT2C ARID1B NONO NCOA2 ANK3 PPP1R13B GEMIN5 CBL KIAA1671 KMT2D GTF2I ICAM5 CSTF2 CTTN

1.07e-065492051538280479
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2B KDM4C KDM6B KMT2C NCOA2 KMT2D

1.10e-0657205618022353
Pubmed

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.

NFATC1 NFATC2 EGR4

2.00e-065205312560487
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

MYF5 KMT2C KMT2D

2.00e-065205332601106
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

MYF5 KMT2B KMT2C KMT2D

2.02e-0616205424368734
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2B KMT2C KMT2D

3.98e-066205317021013
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2B KMT2C KMT2D

6.94e-067205330604749
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2B KMT2C KMT2D

6.94e-067205319556342
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

EPHB4 KCNH8 KMT2B HECW1 ARID1B GBGT1 DMPK CARS2 NONO UBE2Q2 WNK4 WNK2 GALNT14 POC1A KCNH4 PRKCB

7.83e-067302051634857952
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ESS2 TNRC18 TMEM252 FHIP1A WNK4 WNK2 TECPR1 UBQLN2 ANK3 KIAA1671 NCOR2 AATK

1.06e-054302051235044719
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2B KMT2C KMT2D

1.11e-058205322266653
Pubmed

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.

MYF5 KMT2C KMT2D

1.11e-058205330335158
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2B KMT2C KMT2D

1.11e-058205323130995
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2B KMT2C KMT2D

1.65e-059205322665483
Pubmed

NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network.

BLNK NFATC1 NFATC2

1.65e-059205321464221
Pubmed

Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkγ.

BLNK PRKCB PRKD1

2.35e-0510205321482705
Pubmed

Molecular genetics of successful smoking cessation: convergent genome-wide association study results.

TNIK CD109 NPHS2 NRXN3 DSCAM TACC2

3.10e-05101205618519826
Pubmed

NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains.

NFATC1 NFATC2

3.46e-052205226483414
Pubmed

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells.

NFATC1 NFATC2

3.46e-052205217438271
Pubmed

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

CYP4A11 CYP4A22

3.46e-052205215611369
Pubmed

A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.

MAP3K5 CBL

3.46e-052205219597496
Pubmed

NPHS2 gene polymorphism aggravates renal damage caused by focal segmental glomerulosclerosis with COL4A3 mutation.

NPHS2 COL4A3

3.46e-052205233305316
Pubmed

NFAT1 and NFAT2 Differentially Regulate CTL Differentiation Upon Acute Viral Infection.

NFATC1 NFATC2

3.46e-052205230828328
Pubmed

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

CYP4A11 CYP4A22

3.46e-052205223641057
Pubmed

Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).

KMT2B KMT2D

3.46e-052205235640156
Pubmed

Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling.

FGFR4 COL4A3

3.46e-052205235302487
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

3.46e-052205231924266
Pubmed

A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis.

HIP1R CTTN

3.46e-052205217318189
Pubmed

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

CYP4A11 CYP4A22

3.46e-052205228912346
Pubmed

Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.

CYP4A11 CYP4A22

3.46e-052205224413902
Pubmed

Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin.

PRKD1 CTTN

3.46e-052205220363754
Pubmed

Membrane microdomain organization, calcium signal, and NFAT activation as an important axis in polarized Th cell function.

NFATC1 NFATC2

3.46e-052205223184643
Pubmed

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.

CYP4A11 CYP4A22

3.46e-05220528031839
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

3.46e-052205228967912
Pubmed

Crystal structure of Ufc1, the Ufm1-conjugating enzyme.

UBA5 UBE2K

3.46e-052205217825256
Pubmed

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.

CYP4A11 CYP4A22

3.46e-052205210860550
Pubmed

Nuclear factor of activated T cells 1 and 2 are required for vertebral homeostasis.

NFATC1 NFATC2

3.46e-052205232329053
Pubmed

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription.

NFATC1 NFATC2

3.46e-052205212355451
Pubmed

Redundancy in B cell developmental pathways: c-Cbl inactivation rescues early B cell development through a B cell linker protein-independent pathway.

BLNK CBL

3.46e-052205217202354
Pubmed

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.

CYP4A11 CYP4A22

3.46e-052205211320253
Pubmed

Regulation of the murine Nfatc1 gene by NFATc2.

NFATC1 NFATC2

3.46e-052205211786533
Pubmed

Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

CYP4A11 CYP4A22

3.46e-052205212464262
Pubmed

NFATc1 and NFATc2 together control both T and B cell activation and differentiation.

NFATC1 NFATC2

3.46e-052205211163226
Pubmed

Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α.

KDM6B EPAS1

3.46e-052205225520177
Pubmed

Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

CYP4A11 CYP4A22

3.46e-052205215066132
Pubmed

An enhanced immune response in mice lacking the transcription factor NFAT1.

NFATC1 NFATC2

3.46e-05220528629027
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

3.46e-052205236601880
Pubmed

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

NFATC1 NFATC2

3.46e-05220529845362
Pubmed

The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.

NFATC1 NFATC2

3.46e-052205225680272
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

3.46e-052205228483418
Pubmed

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

CYP4A11 CYP4A22

3.46e-052205223825080
Pubmed

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

CYP4A11 CYP4A22

3.46e-052205216691295
Pubmed

The P450 gene superfamily: recommended nomenclature.

CYP4A11 CYP4A22

3.46e-05220523829886
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

3.46e-052205234156443
Pubmed

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.

NFATC1 NFATC2

3.46e-052205225583478
Pubmed

RNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.

HIP1R CTTN

3.46e-052205214742709
Pubmed

Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.

CYP4A11 CYP4A22

3.46e-052205229277328
Pubmed

Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.

KDM6B NFATC1

3.46e-052205221735477
Pubmed

NFATc1 and NFATc2 repress spontaneous osteoarthritis.

NFATC1 NFATC2

3.46e-052205224248346
Pubmed

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.

CYP4A11 CYP4A22

3.46e-052205221820496
Pubmed

Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.

NFATC1 NFATC2

3.46e-052205237933452
Pubmed

Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.

SAMD4B SAMD4A

3.46e-052205216221671
Pubmed

Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.

CYP4A11 CYP4A22

3.46e-052205220943934
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

3.46e-052205227280393
Pubmed

c-Cbl induced podocin ubiquitination contributes to the podocytes injury in diabetic nephropathy.

NPHS2 CBL

3.46e-052205238752545
Pubmed

The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.

CYP4A11 CYP4A22

3.46e-05220522766933
Pubmed

Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.

NFATC1 NFATC2

3.46e-05220527842733
Pubmed

NF-AT components define a family of transcription factors targeted in T-cell activation.

NFATC1 NFATC2

3.46e-05220528202141
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

3.46e-052205236869380
Pubmed

Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.

KMT2B KMT2D

3.46e-052205235506254
Pubmed

Retinoic acid-induced CCR9 expression requires transient TCR stimulation and cooperativity between NFATc2 and the retinoic acid receptor/retinoid X receptor complex.

NFATC1 NFATC2

3.46e-052205221148038
Pubmed

Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection.

NFATC1 NFATC2

3.46e-052205226851216
Pubmed

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.

CYP4A11 CYP4A22

3.46e-052205217112342
Pubmed

BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration.

BLNK CBL

3.46e-052205239413134
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

3.46e-052205225346535
Pubmed

Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.

NFATC1 NFATC2

3.46e-052205218809576
Pubmed

Co-Inheritance of Functional Podocin Variants with Heterozygous Collagen IV Mutations Predisposes to Renal Failure.

NPHS2 COL4A3

3.46e-052205226138234
Pubmed

High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.

CYP4A11 CYP4A22

3.46e-052205230088983
Pubmed

Reciprocal NFAT1 and NFAT2 nuclear localization in CD8+ anergic T cells is regulated by suboptimal calcium signaling.

NFATC1 NFATC2

3.46e-052205217785810
Pubmed

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

CYP4A11 CYP4A22

3.46e-052205219208908
Pubmed

Microglial phenotype is regulated by activity of the transcription factor, NFAT (nuclear factor of activated T cells).

NFATC1 NFATC2

3.46e-052205220631193
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SPAST RAP1GAP2 SULF1 ZC3H7B NUDCD3 SAMD4A

3.66e-05104205610470851
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

MYF5 CYP4A11 NFATC2 GCLC NCOA2 CYP4A22 SLC47A1 SLC7A10

4.03e-05212205819521566
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2B KMT2C KMT2D

4.27e-0512205327563068
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ESS2 BACH2 CDC7 NFATC1 NONO NCOA2 PPP1R13B TACC2 NUDCD3 KIAA1671 NCOR2 SH3BP5L SLX4

5.19e-055882051338580884
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2B KMT2C KMT2D

5.53e-0513205321502505
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TNIK SMG1 HECW1 SIPA1L3 STAB1 KMT2C TRIOBP AATK

6.13e-05225205812168954
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK HECW1 SIPA1L3 MAP3K5 WNK2 NCOA2 ANK3 NRCAM DSCAM TRIOBP KIF7 NCOR2 ICAM5 TJAP1 PRKCB PRKD1 CTTN

6.31e-059632051728671696
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C NCOA2 KMT2D

7.00e-0514205312482968
Pubmed

Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.

NFATC1 NFATC2 PRKCB PRKD1

7.40e-0538205412482669
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

KCNH8 SOCS6 KMT2C CRAMP1 WNK2 TECPR1 NCOA2 GARIN5B

7.82e-05233205837704626
Pubmed

Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.

CYP4A11 CYP4A22

1.03e-04320522354437
Pubmed

Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.

BLNK CBL

1.03e-043205210684856
InteractionTOP3B interactions

EPHB4 KMT2B KIAA0513 AIMP1 SIPA1L3 RAP1GAP2 KDM6B MAST2 REPIN1 ABCA7 ACOX3 MAP3K5 ESRP2 KMT2C TNRC18 NFATC1 TIGD3 ZC3H7B CRAMP1 WNK2 SEMA6B PLOD3 POC1A SH2B3 SAMD4B HIP1R GEMIN5 MLXIP FBXO46 NCOR2 KMT2D AATK GTF2I DNAJC14 GAREM2 NAPRT SH3BP5L SYVN1

3.76e-08147019938int:TOP3B
CytobandEnsembl 112 genes in cytogenetic band chr19q13

NLRP12 KMT2B SIPA1L3 CCNP BCL3 PPP1R13L TMEM91 ALDH16A1 DMPK GARIN5B POLD1 SAMD4B FBXO46 LHB NLRP4 SLC7A10

1.01e-04119220516chr19q13
Cytoband12q24

SH2B3 HIP1R NCOR2

1.88e-0425205312q24
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

MYOM1 DCC ALPK3 FGFR4 NRCAM DSCAM LINGO4 MDGA1

2.54e-051611338593
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

CPAMD8 CD109 A2ML1

3.16e-05913331234
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2B KMT2C PRDM8 KMT2D

1.09e-04341334487
GeneFamilyNuclear factors of activated T-cells

NFATC1 NFATC2

5.29e-0451332665
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC18 NCOR2 KMT2D

7.95e-04251333775
CoexpressionAtlaskidney

HECW1 CYP4A11 CDHR5 FREM2 NPHS2 KHK TMEM252 WNK4 GALNT14 ACOT6 CUBN CYP4A22 SLC47A1

1.34e-0532320113kidney
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK HECW1 SIPA1L3 DCC GALNT14 ANK3 CUBN KIAA1671 SLC47A1 MAP3K13

2.02e-08191204101c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK HECW1 SIPA1L3 DCC GALNT14 ANK3 CUBN KIAA1671 SLC47A1 MAP3K13

2.02e-08191204103c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellwk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TTC39B KIAA0513 ESRP2 FREM2 WNK2 HIP1R KMT2D IFFO2 PRODH

1.96e-071852049636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYOM1 RAP1GAP2 ACOX3 RABGAP1L WNK2 ANK3 PPP1R13B TACC2 SAMD4A

2.24e-0718820496d249fe92d51a19da19ec14bb2262d394255d577
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

TNIK MYOM1 MAST2 FHIP1A WNK2 ANK3 PPP1R13B TACC2 SAMD4A

2.68e-071922049ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HECW1 CYP4A11 CDHR5 DCC KHK CUBN SLC47A1 MAP3K13

2.38e-0618620488287146f0ba415ea04475588117d4668ae00f75c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HECW1 CYP4A11 CDHR5 DCC KHK CUBN SLC47A1 MAP3K13

2.48e-06187204871eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HECW1 CYP4A11 CDHR5 KHK GALNT14 CUBN SLC47A1 MAP3K13

2.58e-061882048f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HECW1 CYP4A11 CDHR5 KHK GALNT14 CUBN SLC47A1 MAP3K13

2.58e-0618820480792432cd4c564dea1102241ea9884f7ced7658c
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH8 RAP1GAP2 FREM2 ALPK3 FHIP1A WNK2 NRCAM HIP1R

2.68e-0618920485d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH8 BLNK RAP1GAP2 FREM2 NRXN3 FHIP1A ANK3 NRCAM

2.68e-0618920487659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

TNIK FREM2 FHIP1A ANK3 PPP1R13B TACC2 PRKD1 MAP3K13

2.90e-061912048a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK PDE9A SIPA1L3 BLNK ANK3 NRCAM HIP1R TACC2

2.90e-0619120483e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

MYOM1 RAP1GAP2 RABGAP1L WNK2 ANK3 PPP1R13B TACC2 SAMD4A

2.90e-0619120485d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

CPAMD8 FREM2 FHIP1A COL4A3 ANK3 DSCAM PPP1R13B MAP3K13

2.90e-061912048d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SIPA1L3 FHIP1A GALNT14 ANK3 TACC2 CUBN SLC47A1 MAP3K13

3.13e-0619320483866667dd221612589ae50f5c52f73a183a49ce6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK CPAMD8 BLNK ANK3 NRCAM WNT9B HIP1R TACC2

3.26e-06194204804bfc555743f7d8821439d05ae442d15e9886c59
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

MYOM1 ACOX3 RABGAP1L WNK2 ANK3 PPP1R13B TACC2 SAMD4A

3.26e-06194204889812fb164065041357bb37a3c2d87028ec3de4e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK CPAMD8 BLNK ANK3 NRCAM WNT9B HIP1R TACC2

3.26e-06194204869bff17df4a760ccf081cf52ff04af02c14f448d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE9A SIPA1L3 RAP1GAP2 FREM2 FHIP1A GALNT14 ANK3 NRCAM

3.51e-061962048eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

KDM4C SIPA1L3 ARID1B RABGAP1L FHIP1A NCOA2 ANK3 PRKD1

3.51e-061962048ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

KDM4C SIPA1L3 ARID1B RABGAP1L FHIP1A NCOA2 ANK3 PRKD1

3.79e-0619820481996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SIPA1L3 FREM2 FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13

3.93e-0619920485cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPAST SOCS6 SEMA6B PPP1R13B AARSD1 FGFBP3 ENTPD6 NUP93

3.93e-0619920485db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FHIP1A WNK2 ANK3 PPP1R13B TACC2 BCAS1 KIAA1671 MAP3K13

4.08e-062002048d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellP28-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TMEM91 KMT2C TNRC18 ALDH16A1 DMPK POC1A ENTPD6

1.27e-0516820478c8dbdbc7053f34e4ca0c5067af502fbea109fc1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 TMEM74B CD109 MGST2 SULF1 SLC35E4 EPAS1

1.32e-051692047c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS6 CCNP ERMP1 COL4A3 BCAS1 NCOR2 NUP93

1.59e-05174204746bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCellControl-CD4+_T_activated|Control / Disease group and Cell class

PDE9A BACH2 BCL3 NFATC1 TESK2 FHIP1A MAP3K13

1.59e-0517420472b683e81b315ad22555314433aed5681feb48da8
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAM11 TNRC18 ILVBL ANK3 NRCAM AATK PRODH

1.65e-051752047bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB4 MYOM1 GBGT1 CACNA1F ACOT6 BCAS1 RAB34

1.78e-0517720474a697866ed542d3201714234cee03451adf1dcc9
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

HECW1 CYP4A11 CDHR5 FREM2 GALNT14 CUBN SLC47A1

1.84e-05178204723a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS6 CCNP ERMP1 COL4A3 BCAS1 NCOR2 NUP93

1.91e-05179204755bc69f107fc710db7617c428575792adfdbbcc1
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR5 ESRP2 GCLC FGFR4 CREB3L3 SLC47A1 PRODH

2.12e-05182204777ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR5 ESRP2 GCLC FGFR4 CREB3L3 SLC47A1 PRODH

2.12e-0518220474921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR5 ESRP2 GCLC FGFR4 CREB3L3 SLC47A1 PRODH

2.12e-051822047770ce9f3f4538d0181a0181543841bc964c68274
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR5 KHK COL4A3 GALNT14 PPP1R13B CUBN SLC47A1

2.12e-051822047faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR5 KHK COL4A3 GALNT14 PPP1R13B CUBN SLC47A1

2.12e-051822047be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GAS6 CCNP ERMP1 COL4A3 BCAS1 NCOR2 NUP93

2.20e-05183204783592c332b1e82673f993d37c7f480befdc3dcda
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH8 ADAM11 TESK2 POC1A ANK3 BCAS1 AATK

2.20e-0518320472cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KCNH8 BLNK RAP1GAP2 ESRP2 FREM2 FHIP1A NRCAM

2.20e-051832047c5b10571599dc26476170b54b53f09c23e6b3117
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH8 ADAM11 TESK2 POC1A ANK3 BCAS1 AATK

2.20e-05183204798fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

RAP1GAP2 CSMD2 RABGAP1L CX3CL1 EGR4 ICAM5 PRKCB

2.28e-0518420476e17c8151d6dc543de16d804db956c63c3fda414
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

GAS6 ABCA7 COL4A3 DSCAM NCOR2 AATK MDGA1

2.28e-051842047cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell343B-Epithelial_cells-Epithelial-I_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

GAS6 ABCA7 COL4A3 DSCAM NCOR2 AATK MDGA1

2.28e-051842047bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH8 ADAM11 TESK2 AMH POC1A NRCAM AATK

2.28e-051842047da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

NRXN3 FHIP1A WNK2 ANK3 TACC2 MAP3K13 MUC4

2.36e-051852047cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 DIO2 GRIN2C RAB34 GAREM2 SLC7A10 PRODH

2.44e-05186204773cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4A11 SIPA1L3 CDHR5 PPP1R13B CUBN KIAA1671 MAP3K13

2.44e-051862047b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK HECW1 DCC GALNT14 SLC47A1 MAP3K13 SAMD4A

2.53e-0518720479d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCelldroplet-Kidney-nan-18m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS6 CDHR5 TMEM252 ANK3 CUBN SLC47A1 PRODH

2.53e-051872047236e9857729670e87eed30fad58f49e1f56e4a85
ToppCellLV-04._Ventricular_Cardiomyocyte_I|World / Chamber and Cluster_Paper

TNIK MYOM1 PPP1R13L FHIP1A WNK2 PPP1R13B TACC2

2.62e-0518820470758b474457efa36488e0195f7357100f4b6a090
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE9A BLNK FREM2 FHIP1A WNK4 COL4A3 GALNT14

2.62e-0518820471d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13 MUC4

2.62e-051882047c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

TTC39B BACH2 SIPA1L3 MAP3K5 FREM2 NRXN3 ANK3

2.62e-051882047b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

TNIK MYOM1 MAST2 WNK2 ANK3 PPP1R13B TACC2

2.71e-0518920479c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK HECW1 KHK GALNT14 CUBN SLC47A1 MAP3K13

2.71e-051892047204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS6 BCL3 KDM6B CX3CL1 SAMD4B NCOR2 IFFO2

2.71e-051892047965e0e388251e7318f8b463816dc96ccb4658677
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

MYOM1 MAST2 ALPK3 FHIP1A ANK3 TACC2 SAMD4A

2.71e-0518920470a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK HECW1 KHK GALNT14 CUBN SLC47A1 MAP3K13

2.71e-05189204713fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB4 ACR STAB1 SULF1 FAM181B CX3CL1 EPAS1

2.71e-0518920472e43428f1ef9683c6f8c9897d46aa7d34bf9047f
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 DIO2 GRIN2C RAB34 GAREM2 SLC7A10 PRODH

2.80e-0519020475c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RAP1GAP2 FREM2 NRXN3 FHIP1A NRCAM HIP1R KIAA1671

2.80e-051902047625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

MYOM1 MAST2 ALPK3 FHIP1A ANK3 TACC2 SAMD4A

2.80e-05190204793c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

TNIK MYOM1 RABGAP1L WNK2 PPP1R13B TACC2 SAMD4A

2.80e-051902047de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DIO2 FAM181B GRIN2C RAB34 GAREM2 SLC7A10 PRODH

2.80e-051902047b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13

2.89e-051912047e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

MYOM1 RABGAP1L WNK2 ANK3 PPP1R13B TACC2 SAMD4A

2.89e-05191204725f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

PDE9A BLNK FHIP1A WNK4 COL4A3 GALNT14 PRKD1

2.89e-051912047fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Interneuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

NRXN3 CX3CL1 NCOA2 IFFO2 SLC47A1

2.94e-057820458ad496ccbffb62a50f195c3789a95d8c80e2272d
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

FREM2 FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13

2.99e-051922047499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

CPAMD8 CX3CL1 FHIP1A ANK3 TACC2 CTTN MUC4

2.99e-051922047d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

FREM2 FHIP1A ANK3 PPP1R13B TACC2 PRKD1 MAP3K13

2.99e-05192204758c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

TNIK MYOM1 ALPK3 FHIP1A ANK3 TACC2 SAMD4A

3.09e-051932047dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CPAMD8 FREM2 FHIP1A COL4A3 ANK3 PPP1R13B MAP3K13

3.09e-051932047a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|367C / Donor, Lineage, Cell class and subclass (all cells)

LVRN TMEM74B KDM4C TGFBRAP1 SLC47A1 PRODH

3.15e-051312046aeeb5718b3a7122492ad2659d5c8112f60839ff3
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

MYOM1 RABGAP1L WNK2 ANK3 PPP1R13B TACC2 SAMD4A

3.20e-051942047c3535f7cc0076653c72db582047cff053c322397
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

KCNH8 RAP1GAP2 FREM2 FHIP1A NRCAM DSCAM AMER3

3.20e-051942047b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

TNIK MYOM1 ALPK3 FHIP1A WNK2 ANK3 TACC2

3.30e-051952047f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellBronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH8 GAS6 BLNK CDHR5 TIGD3 FHIP1A PRKCB

3.30e-051952047fbc324c3435f32b9ca269d83333faecfe940d7fe
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SIPA1L3 RAP1GAP2 FREM2 FHIP1A COL4A3 GALNT14 ANK3

3.41e-0519620476ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GAS6 BLNK CDHR5 TIGD3 FAM181B FHIP1A PRKCB

3.41e-051962047b10b386aacc672949560df2dbb0d4f76cf62e213
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPAMD8 PDE9A FHIP1A COL4A3 GALNT14 ANK3 PRKD1

3.52e-0519720477e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PPP1R13L NRXN3 COL4A3 CACNA1F ANK3 LMNTD2 ICAM5

3.52e-0519720473d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK FREM2 ANK3 PPP1R13B TACC2 PRKD1 MAP3K13

3.64e-0519820472e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK DCC FREM2 FHIP1A TACC2 PRKD1 MAP3K13

3.64e-051982047f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-CD4+_CTL|Int-URO / Disease, condition lineage and cell class

TNIK NFATC2 L3HYPDH HIP1R PPP1R13B SMTN MDGA1

3.64e-051982047717735d755745439f97ba1b71785c73945dfa9c5
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13

3.76e-0519920475f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

KDM4C SIPA1L3 KMT2C ARID1B RABGAP1L NCOA2 ANK3

3.76e-05199204794b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPAST SOCS6 SEMA6B AARSD1 FGFBP3 ENTPD6 NUP93

3.76e-05199204750e2da35edff1aadef939cfbd4549f73c1a07717
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 FHIP1A COL4A3 ANK3 PPP1R13B TACC2 MAP3K13

3.76e-0519920478587bd98de7767a575088afbea07a1feb4516b9b
ToppCellCOVID-19_Moderate-B_cell|World / disease group, cell group and cell class

BACH2 CCNP ADAM11 AMH PCDHGA7 AARSD1

4.39e-051392046b93e1da87d44e55d75e8cc1b87c2970645679c01
ToppCellCOVID-19_Moderate-B_cell|COVID-19_Moderate / disease group, cell group and cell class

BACH2 CCNP ADAM11 AMH PCDHGA7 AARSD1

4.95e-05142204688bb8d9bca66131df4ee7021b88248e146aa7aa6
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MYOM1 RAP1GAP2 STAB1 CDAN1 GCLC FGFBP3

6.47e-051492046a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MYOM1 RAP1GAP2 STAB1 CDAN1 GCLC FGFBP3

6.71e-0515020467a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NPHS2 FAM229A GBGT1 FGFR4 WNK4

7.59e-059520453699ea16660a22ea79fecfea56ece2dfb0f13467
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NPHS2 FAM229A GBGT1 FGFR4 WNK4

7.59e-05952045cbfe615d880913bafaf5e7e8d24c3ec14a9351ce
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NPHS2 FAM229A GBGT1 FGFR4 WNK4

7.59e-0595204527ac23b87747434a3084cc087e7b884e68f0eab9
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

PRDM8 TGFBRAP1 CACNA1F ANK3 TJAP1 EPAS1

7.76e-05154204626bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCellPBMC-Severe-cDC_4|Severe / Compartment, Disease Groups and Clusters

NLRP12 KIAA0513 TMEM91 POC1A TMEM177 DNAJC14

9.58e-0516020464dac64e58d9366c399f3d830848ccb720d400be7
DrugAminohippuric acid [61-78-9]; Up 200; 20.6uM; HL60; HT_HG-U133A

HECW1 BLNK MAST2 AMH DSCAM BCAS1 NCOR2 ICAM5 CTTN MUC4 SAMD4A

1.51e-06197201113076_UP
Drugchlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A

KDM6B MAST2 RGP1 FGFR4 ZC3H7B PLPPR2 AMH ARHGDIG ZNF747 EPAS1

1.06e-05197201106936_UP
DrugFlorfenicol [73231-34-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A

SIPA1L3 GAS6 ACOX3 TGFBRAP1 FGFR4 GALNT14 ANK3 SH2B3 GTF2I SAMD4A

1.06e-05197201105300_DN
DrugGelsemine [509-15-9]; Down 200; 12.4uM; MCF7; HT_HG-U133A

KIAA0513 TNFSF9 SIPA1L3 GAS6 KDM6B TESK2 FGD1 DSCAM CBL ARHGDIG

1.11e-05198201102817_DN
DrugSulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT_HG-U133A

TNIK KDM4C GAS6 SOCS6 MAST2 ZC3H7B DMPK EPM2A ARHGDIG PRKCB

1.16e-05199201103616_DN
Diseaselung non-small cell carcinoma (is_implicated_in)

KMT2C ARID1B FGFR4 NCOA2 CBL KMT2D PRKCB EPAS1

4.24e-061391958DOID:3908 (is_implicated_in)
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KDM4C DCC KMT2C FGFR4 KMT2D

1.18e-05451955DOID:3748 (is_implicated_in)
DiseaseMetastatic melanoma

EPHB4 ALPK3 WNK4 PRKD1 MAP3K13

2.91e-05541955C0278883
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

4.35e-0521952DOID:0080598 (implicated_via_orthology)
DiseaseE3 ubiquitin-protein ligase CBL measurement

NLRP12 CBL

4.35e-0521952EFO_0801552
Diseasecalcyclin-binding protein measurement

NLRP12 RABGAP1L

4.35e-0521952EFO_0801443
DiseaseColorectal Carcinoma

CPAMD8 CD109 DCC KMT2C NFATC1 PLPPR2 NRCAM POLD1 CUBN KCNH4 PPOX SMTN ICAM5 PRKCB PRKD1

7.27e-0570219515C0009402
Diseasemetabolite measurement

CYP4A11 DCC STAB1 L3HYPDH KHK NBPF3 ANK3 DSCAM ACOT6 NAPRT SLC47A1 MDGA1 PRODH

9.82e-0556019513EFO_0004725
DiseaseColorectal Neoplasms

CPAMD8 CD109 DCC NRCAM POLD1 PPOX ICAM5 PRKCB PRKD1

1.01e-042771959C0009404
Diseasetubulin-specific chaperone E measurement

NLRP12 TBCE

1.30e-0431952EFO_0802167
Diseaseprogressive myoclonus epilepsy (is_implicated_in)

SEMA6B EPM2A

1.30e-0431952DOID:891 (is_implicated_in)
Diseasesmoking behavior, smoking status measurement, systolic blood pressure

NRXN3 DIO2

2.58e-0441952EFO_0004318, EFO_0006335, EFO_0006527
Diseaseprotein DGCR14 measurement

NLRP12 ESS2

2.58e-0441952EFO_0801940
DiseaseHematuria, Benign Familial

NPHS2 COL4A3

2.58e-0441952C0241908
Diseaselatent autoimmune diabetes in adults

BACH2 RBM17

2.58e-0441952EFO_0009706
Diseasesitting height ratio

ARID1B NFATC2 FGFR4 MDGA1

3.63e-04511954EFO_0007118
DiseaseAlport Syndrome, X-Linked

NPHS2 COL4A3

4.29e-0451952C1567742
DiseaseAlport Syndrome, Autosomal Dominant

NPHS2 COL4A3

4.29e-0451952C1567743
DiseaseAlport Syndrome, Autosomal Recessive

NPHS2 COL4A3

4.29e-0451952C1567744
Diseaseapolipoprotein A 1 measurement

TTC39B UBE2K SPAST BCL3 STAB1 GPR149 FGFR4 CREB3L3 NCOA2 SH2B3 HIP1R MLXIP NCOR2 NUP93 SLC7A10

5.49e-0484819515EFO_0004614
Diseaseprostate cancer (is_marker_for)

KMT2B KDM4C KMT2C FGD1 NCOA2 KMT2D

6.17e-041561956DOID:10283 (is_marker_for)
Diseasehypertensive nephropathy

NPHS2 COL4A3

6.40e-0461952C0848548
Diseasepseudohypoaldosteronism (implicated_via_orthology)

WNK4 WNK2

6.40e-0461952DOID:4479 (implicated_via_orthology)
Diseaseartificially sweetened beverage consumption measurement

KDM4C NKX1-1

6.40e-0461952EFO_0010096
DiseaseC-C motif chemokine 22 measurement

BACH2 CX3CL1

6.40e-0461952EFO_0020196
DiseaseFamilial erythrocytosis

SH2B3 EPAS1

6.40e-0461952cv:C0152264
DiseaseX-14939 measurement

CYP4A11 CYP4A22

6.40e-0461952EFO_0800747
Diseasedaytime rest measurement

KCNH8 NRXN3 GCLC RABGAP1L DSCAM AATK PRKCB MDGA1

8.13e-042951958EFO_0007828
Disease10-undecenoate 11:1n1 measurement

CYP4A11 MAST2

8.93e-0471952EFO_0021099
DiseaseX-18899 measurement

UBA5 CYP4A11

8.93e-0471952EFO_0800793
Diseasesurvival time, coronary artery disease

PDE9A RAP1GAP2 PRKD1

1.01e-03301953EFO_0000714, EFO_0001645
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

NPHS2 COL4A3 NUP93

1.01e-03301953C1868672
DiseaseLeukemia, Myelocytic, Acute

BACH2 KMT2C SH2B3 CBL GTF2I SLX4

1.06e-031731956C0023467
Diseasecreatinine measurement, glomerular filtration rate

SIPA1L3 NFATC1 UBE2Q2 BCAS1 SLC47A1

1.10e-031171955EFO_0004518, EFO_0005208
DiseaseOvarian Mucinous Adenocarcinoma

MAST2 WNK4 AATK

1.11e-03311953C1335167
Diseasefeeling tense measurement

RABGAP1L ZC3H7B AATK

1.34e-03331953EFO_0009596
Diseasehyperuricemia

SIPA1L3 NFATC1 BCAS1

1.34e-03331953EFO_0009104
Diseaseunderweight body mass index status

DCC NRXN3

1.52e-0391952EFO_0005936
Diseasetetradecanedioate measurement

CYP4A11 MDGA1

1.52e-0391952EFO_0021057
Diseasecoronary aneurysm

CSMD2 NRXN3 MDGA1

1.59e-03351953EFO_1000881
Diseaselymphocyte percentage of leukocytes

TNIK BACH2 RAP1GAP2 ABCA7 NFATC1 ZC3H7B AARSD1 AATK ICAM5 SLC47A1 SLC7A10 RBM17

1.66e-0366519512EFO_0007993
Diseaseresponse to serotonin-norephinephrine reuptake inhibitor

NFATC1 NFATC2 ANK3

1.73e-03361953EFO_0006325
Diseasecitrate measurement

ESS2 NFATC1 WNK2 SAMD4A

1.89e-03791954EFO_0010114
DiseaseTPE interval measurement, response to exercise

NRXN3 DIO2

1.89e-03101952EFO_0004644, EFO_0007768
DiseaseX-11315 measurement

NAPRT PRODH

2.30e-03111952EFO_0021223
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 CYP4A22

2.30e-03111952DOID:0110861 (biomarker_via_orthology)
DiseaseSchizophrenia

TNIK ESS2 DCC CSMD2 NRXN3 GCLC CACNA1F ANK3 ACOT6 GRIN2C EGR4 MDGA1 SLC7A10 PRODH

2.32e-0388319514C0036341
Diseasevaline measurement

NFATC1 MLXIP PRODH

2.35e-03401953EFO_0009792
Diseaseuric acid measurement

TNIK SIPA1L3 PRDM8 NFATC1 NFATC2 RNASEH2C DSCAM BCAS1 MLXIP CUBN EPAS1

2.58e-0361019511EFO_0004761
Diseaseneutrophil percentage of leukocytes

RAP1GAP2 ABCA7 NFATC1 TGFBRAP1 ZC3H7B AARSD1 AATK ICAM5 SLC47A1 SLC7A10 RBM17

2.58e-0361019511EFO_0007990
DiseaseHematologic Neoplasms

SH2B3 CBL

2.75e-03121952C0376545
Diseasedodecanedioate measurement

CYP4A11 MDGA1

2.75e-03121952EFO_0021054
Diseasehematocrit

PDE9A GAS6 MAST2 STAB1 PRDM8 ARID1B RABGAP1L UBE2Q2 COL4A3 SH2B3 PPP1R13B NCOR2 LINGO4 SLC7A10 EPAS1

3.07e-03101119515EFO_0004348
DiseaseAmino Acid Metabolism, Inherited Disorders

GCLC PRODH

3.23e-03131952C0750905
Diseasefructose measurement

TNIK IFFO2

3.23e-03131952EFO_0010477
Diseaseundecenoylcarnitine (C11:1) measurement

CYP4A11 ACOT6

3.23e-03131952EFO_0800588
Diseasesystolic blood pressure, cigarettes per day measurement

NRXN3 DIO2

3.23e-03131952EFO_0006335, EFO_0006525
DiseaseAmino Acid Metabolism, Inborn Errors

GCLC PRODH

3.23e-03131952C0002514
DiseaseNeurodevelopmental Disorders

SPAST KMT2C ARID1B DSCAM

3.42e-03931954C1535926
Diseaserespiratory quotient

DCC AATK

3.75e-03141952EFO_0005189
DiseaseMale sterility

CBL LHB KMT2D

3.95e-03481953C0917731
DiseaseMale infertility

CBL LHB KMT2D

3.95e-03481953C0021364
DiseaseSubfertility, Male

CBL LHB KMT2D

3.95e-03481953C0848676
Diseaselymphocyte count

TNIK SPAST BACH2 GAS6 RAP1GAP2 CMTM6 NFATC1 NFATC2 ZC3H7B NCOA2 SH2B3 PCDHGA7 CBL CD5L ICAM5 PRKCB SLC47A1 SLC7A10 RBM17

3.98e-03146419519EFO_0004587
DiseaseHypogonadotropic hypogonadism

POLD1 LHB

4.31e-03151952C0271623
DiseasePrimary hypogonadism

POLD1 LHB

4.31e-03151952C0948896
DiseaseHypogonadism, Isolated Hypogonadotropic

POLD1 LHB

4.31e-03151952C3489396
DiseaseAdenoid Cystic Carcinoma

GAS6 KDM6B KMT2C FGFR4

4.43e-031001954C0010606
Diseasewhite matter microstructure measurement

TNIK KMT2B DCC MAST2 NFATC1 SLC27A3 SH2B3 MAP3K13

4.59e-033901958EFO_0005674
Diseaseresponse to trauma exposure

ILVBL NCOA2 MAP3K13

4.69e-03511953EFO_0008483
DiseaseHypogonadism

POLD1 LHB

4.91e-03161952C0020619
DiseaseT-Cell Lymphoma

KDM4C KMT2D

4.91e-03161952C0079772
DiseaseVitiligo

BACH2 SH2B3

5.54e-03171952C0042900
Diseasecopine-1 measurement

NLRP12 TRPC4AP

5.54e-03171952EFO_0008102
DiseaseHypogammaglobulinemia

BACH2 BLNK

5.54e-03171952C0086438
DiseaseFamilial Progressive Myoclonic Epilepsy

PRDM8 EPM2A

5.54e-03171952C0751777
DiseaseAtypical Inclusion-Body Disease

PRDM8 EPM2A

5.54e-03171952C0751776
DiseaseMyoclonic Epilepsies, Progressive

PRDM8 EPM2A

5.54e-03171952C0751778
Diseaseglomerulonephritis (implicated_via_orthology)

GAS6 COL4A3

5.54e-03171952DOID:2921 (implicated_via_orthology)
DiseaseBiotin-Responsive Encephalopathy

PRDM8 EPM2A

5.54e-03171952C0751780
DiseaseMay-White Syndrome

PRDM8 EPM2A

5.54e-03171952C0751782
DiseaseDentatorubral-Pallidoluysian Atrophy

PRDM8 EPM2A

5.54e-03171952C0751781
Diseaseischemia (implicated_via_orthology)

ARID1B CX3CL1

5.54e-03171952DOID:326 (implicated_via_orthology)
Diseaseresponse to lithium ion

CSMD2 NRXN3 EPAS1

6.09e-03561953GO_0010226
DiseaseAction Myoclonus-Renal Failure Syndrome

PRDM8 EPM2A

6.20e-03181952C0751779
DiseaseJT interval

TRPC4AP ALPK3 FHIP1A NCOA2 ENTPD6 EPAS1

6.28e-032481956EFO_0007885

Protein segments in the cluster

PeptideGeneStartEntry
PGAERPEEPGATFSK

nan

21

A8MZ25
PPDPAAVAAAREGTG

AMER3

21

Q8N944
EPPQGRRFPIEAGDS

FAM229A

56

H3BQW9
GAERELRPAPPTGAS

EPM2A

161

B3EWF7
DQRTEFLGAAPLGPP

EPAS1

656

Q99814
LEGTDPGTFSERGPP

BACH2

796

Q9BYV9
TERRGTILSPGFPEP

CSMD2

1801

Q7Z408
EAGPRGELSVSTPVP

COL4A3

641

Q01955
VAADAVPGSEAPGPR

CREB3L3

371

Q68CJ9
PPDFVLDSPIGRADG

ACOX3

646

O15254
FGLAVPSTLPAGPEI

ALDH16A1

506

Q8IZ83
PRRSSPVGAEAGPED

SH3BP5L

286

Q7L8J4
SPVPGTVPGASERVA

SLC7A10

21

Q9NS82
VEITPPISCGRFIGP

ACR

146

P10323
PFAEGPLATRIVPTD

ALG9

501

Q9H6U8
PPNGSVPGDRITFDA

AIMP1

241

Q12904
VPGDRITFDAFPGEP

AIMP1

246

Q12904
QPVPFGLVRFGVAPD

FDXR

71

P22570
GPRSSEGPLSFPVLV

FGFR4

576

P22455
FLVPPPAGGTEEVAT

A2ML1

81

A8K2U0
ARAAPGFGEVPEIIP

ALPK3

1691

Q96L96
GPGAPEVTEPSRLVR

ADAM11

41

O75078
VPGIGRELSTPVTFP

CYP4A11

386

Q02928
AGPVRAALFLPPDEG

ACOT6

141

Q3I5F7
AGPPASVETLGPRVA

AARSD1

356

Q9BTE6
IERGEEPPPEVFSTG

ARID1B

1226

Q8NFD5
FSPVPEGVRLADGPG

CD5L

131

O43866
RPDELPAGSLPFTGR

LVRN

116

Q6Q4G3
DGFPAGPTVSPRRLA

CCNP

46

Q9H8S5
TVEAVAAAGSPPRFP

CDHR5

341

Q9HBB8
SVTGEVEPRGYLGPP

CSTF2

336

P33240
SLAVGPRDPDEGVSP

CDAN1

1036

Q8IWY9
FTPILGRSGSEIPPD

ERMP1

606

Q7Z2K6
GSGFSPPTPVRAEAE

ARMCX2

66

Q7L311
ASAIAPPPGVTEALG

ARMCX2

136

Q7L311
QVPSAGSFPVLGDPI

PPP1R13B

351

Q96KQ4
FAESLPSVGGQIIPP

PHYKPL

211

Q8IUZ5
VEEAPPGLSPGVSVR

ABCA7

796

Q8IZY2
PAGARVVSGRFPLPT

ANTKMT

166

Q9BQD7
ESEPSYISDVGPPGR

NUP93

161

Q8N1F7
TAPGVRFPLSEAGDP

PCDHGA7

146

Q9Y5G6
VPVGSLIDFGPEAPT

KIAA0513

6

O60268
PISPSGPFQIIFEGV

MDGA1

881

Q8NFP4
GGQPPPRVFLAVFVE

PLOD3

291

O60568
LPVGDRLPDSLSFGP

CACNA1F

1681

O60840
PLPTGFTGRDPVALV

MUC4

4381

Q99102
AFDPTSIPRGIPLDA

NCOR2

1631

Q9Y618
AASPRFTLPVPGFEG

NFATC2

146

Q13469
DFPVPPGRGRSVESV

POC1A

331

Q8NBT0
ASPPARPTVAGFAGE

FGFBP3

151

Q8TAT2
PVPFPTLSVDRGFGA

DCC

1281

P43146
GPSVDPEIPSFSGLR

DNAJC14

26

Q6Y2X3
ERPLVVNFGSATUPP

DIO2

121

Q92813
APFLAPVAAPVGGIS

PRKD1

36

Q15139
IPSPEGEFGDEFVPR

MYF5

21

P13349
PDGTLGLTPPTTERF

NONO

421

Q15233
RLPFSAPPGSVVEAS

KMT2C

2571

Q8NEZ4
GPFIVAAREGDPGPA

KIAA1671

911

Q9BY89
GVSSLATGPVPFEPV

EPHB4

411

P54760
APGAVAGAAEVPREP

NUDCD3

151

Q8IVD9
EGPASPDRVFNTPEG

NRCAM

936

Q92823
ERSPEGLESPVAGPS

HECW1

781

Q76N89
GCPRGVDPVVSFPVA

LHB

91

P01229
PRVPGVVGAEPFSAK

FREM2

2511

Q5SZK8
LEELFFGTEGPPRPA

KDM6B

501

O15054
PAPVVFVSAEQGGPA

FBXO46

196

Q6PJ61
PVVAELAASPPGGVR

ICAM5

746

Q9UMF0
GAFESGQVEPRPREP

PDE9A

121

O76083
IPRPTEGGVVARAEP

EVPLL

166

A8MZ36
SFPRLGCPGFTLPEV

GCLC

146

P48506
SPKTTDPEEGFPRGL

NFATC1

211

O95644
PTEPGIRRVPGASEV

NRXN3

1546

Q9Y4C0
AERPPEETASGARGP

KIF7

361

Q2M1P5
AGTPGEPRAPAATVV

NPHS2

51

Q9NP85
PGEIPAVPSGERNSF

KDM4C

541

Q9H3R0
GTFGPPDLSPRIVDG

KCNH4

816

Q9UQ05
EREAARAGPEGTSPP

KMT2B

481

Q9UMN6
LYPGPGPEVTVTRAG

AMH

166

P03971
AGPPPSEGEESTVRF

PRKCB

6

P05771
DRFPLPEAGPGADTR

LMNTD2

486

Q8IXW0
VFNLFTPEGAEGPTP

NLRP4

376

Q96MN2
LVADIPGSSGVAAPP

EGR4

431

Q05215
PLDVFPAGASVLRGP

FAM181B

286

A6NEQ2
GLRDSVPPFTPDFEG

DMPK

346

Q09013
RPSSPGGLPEEDSVL

RABGAP1L

116

Q5R372
PDRPGPDRFVTDQGA

PLPPR2

176

Q96GM1
PTEPIRTPIIAGGLF

GALNT14

271

Q96FL9
GRVVSLSPEDAPGPS

GPR149

246

Q86SP6
LFDGPSRPSVARDGP

PCF11

751

O94913
GSLDIPSAEPVGRSP

MAP3K13

741

O43283
IAPAAIARAPGVPEF

MLXIP

611

Q9HAP2
GPDVETSPFGAPRAA

NBPF3

16

Q9H094
FAVDAPDGVLPTIAP

CUBN

1961

O60494
VDRTPGPAFKILEPG

ESS2

336

Q96DF8
AVAPGPRFLVTAPGI

CD109

21

Q6YHK3
TSGPVERPFPEAFSE

FHIP1A

471

Q05DH4
GSPGEEVAIRPSTAP

HIP1R

1016

O75146
AQSGTPGPVFVELPV

ILVBL

196

A1L0T0
PRFTEGGNPTVDGPL

BLNK

311

Q8WV28
VTVETPPEPGATAFR

DOK1

76

Q99704
IFTDNPAAVPGVPLG

GBGT1

146

Q8N5D6
TPVEEAPRGALVRGP

ARHGDIG

181

Q99819
APRAGTPGFRAPEVL

CDC7

371

O00311
RSPVLTFAGGLPDVP

GAS6

616

Q14393
TFAGGLPDVPVTSAP

GAS6

621

Q14393
LPRPPEVQFIGFSTG

CPAMD8

1066

Q8IZJ3
VPGIGRELSTPVTFP

CYP4A22

386

Q5TCH4
VGGSDPFVSIPSRPE

CRAMP1

1011

Q96RY5
PFGLAVEDRSPATTP

ANK3

3566

Q12955
GPGPSPVTAALRDDL

IFFO2

36

Q5TF58
RAAGPSEPLGEVAPR

MARCHF11

61

A6NNE9
APRFPEGPEEASSTL

MAST2

936

Q6P0Q8
LLFLPPAAPGGEVTS

KHDC4

26

Q7Z7F0
PPPRVVDTLGAGDTF

KHK

246

P50053
TEPIVVDPFDPRGSG

CBL

426

P22681
VEGLPEGVPFRRPST

GTF2I

771

P78347
AARDPTLLPPETGGA

BCAS1

166

O75363
SPEPAAPRGAAGLVV

BCL3

41

P20749
LGPRIIAPPSFDGTT

C4orf54

1771

D6RIA3
DPGSAPSLGDRVPYV

POLD1

911

P28340
LSPITEGSEARAGPP

PPP1R13L

566

Q8WUF5
PFLSVRPGPTVASGE

LILRA3

326

Q8N6C8
ITVPGIPGPFFLDSR

LINGO4

516

Q6UY18
GPDVREGTLPTFDPT

PAGE5

106

Q96GU1
VPEVTGDAPSAFRPL

POM121L1P

61

Q3SYA9
PQPSFFLVGIPGLEE

OR52L2P

26

Q8NGH6
DEGITFSVPPFAPSG

MAP3K5

6

Q99683
TPPAVTGSPEFERVF

MGST2

36

Q99735
FTRTKEDVPGPPAGV

DSCAM

1181

O60469
ISFGAAGPPRREPEA

GAREM2

451

Q75VX8
VPPAGFAGLTPEELR

SYVN1

476

Q86TM6
PEGPRSPAVFGAIIS

CARS2

441

Q9HA77
REECPVFTPPGGETL

TIGAR

111

Q9NQ88
VSVTAREDVPTFGPP

RAP1GAP2

401

Q684P5
ASIVFPPPGASEENG

TRPC4AP

351

Q8TEL6
FLPRVEGTLQASPPG

ENTPD6

261

O75354
ESPTRELGEPFPGAK

AATK

1246

Q6ZMQ8
SPGATVDEAAAPGPR

NKX1-1

236

Q15270
SEVLPIEGPPSFRGQ

RGP1

116

Q92546
ENGRLFAPPSPETGE

PRDM8

366

Q9NQV8
SIGERFSPIRGPPIT

SMG1

411

Q96Q15
RSLPLIGFEVGPPEA

FGD1

866

P98174
GSATAVRPPVPAVDF

PRODH

41

O43272
GRREPSFASPAGLEP

SIPA1L3

1551

O60292
SASAPAPVPGGEAER

SPAST

101

Q9UBP0
PTDVLGFLGPECPVT

ESRP2

371

Q9H6T0
GDVEGAAPAPRTPIT

REELD1

191

A0A1B0GV85
LDFGLVPAPPAGTRE

L3HYPDH

116

Q96EM0
AGLPEEGPTAAPRSR

TRIOBP

91

Q9H2D6
EPAPVRGGPEATLEV

SLC47A1

6

Q96FL8
PVVSFIAGLTAPPGR

SUCLG1

281

P53597
AVTAPRPGGDAVDRP

REPIN1

221

Q9BWE0
GGVLASAPDPPVLRE

SLX4

141

Q8IY92
VYSPTTEEDPGPARG

CMTM6

6

Q9NX76
LFPDTRPGAPAGSVD

NCOA2

821

Q15596
TARGSPEEELPLPAF

TJAP1

296

Q5JTD0
VAFPEQDGSPPGLRV

PPOX

351

P50336
DFVEGPEPRVDSPGR

TNRC18

1221

O15417
PPVPGGLSLEEFSRF

TIGD3

381

Q6B0B8
PVFVGSGPGRLTPAE

SEMA6B

46

Q9H3T3
LEERPVPAGPATFTA

TGFBRAP1

51

Q8WUH2
DPPFVRVVLPVLSGG

UBE2Q2

281

Q8WVN8
AVSDIPRLIPTGAPG

TNIK

856

Q9UKE5
SAPLGPVAPTREGVE

TMEM74B

46

Q9NUR3
LSPEPRAGVGSEFPA

TTC39B

41

Q5VTQ0
PQDIVSSPGPVGFED

ZP1

566

P60852
ILTDDPEGGPARIPF

ROPN1L

151

Q96C74
PSPEELGARAAFTTP

SAMD4B

251

Q5PRF9
ATVRFAGVVPPVAGP

TBCE

21

Q15813
PGATVALLLPAGPEF

SLC27A3

166

Q5K4L6
LSYRGPVSGTEPEPV

CTTN

431

Q14247
NFSGPVPDLPEGITV

UBA5

356

Q9GZZ9
DPVPSGFSAGEVLIP

RBM17

81

Q96I25
ASSEVERPGPGQILP

TECPR1

416

Q7Z6L1
LTPVRGDLDPPVGFQ

ZNF747

306

Q9BV97
GESPGTPPFRVIGEL

GEMIN5

46

Q8TEQ6
VAVDGPAPVGRFFTP

RNASEH2C

36

Q8TDP1
AAPGTPGEAAETPAR

SH2B3

161

Q9UQQ2
PEAPPVAAGVGAVLA

STAB1

2471

Q9NY15
VRALPEGSLAFPGVP

NAPRT

106

Q6XQN6
DGPRSDSVEGSPFRP

TACC2

2001

O95359
REASGIPPPLYTETG

TMEM252

116

Q8N6L7
GLFRVTPEIPAGLPS

TNFSF9

236

P41273
VLEPGLASSPGVAPA

nan

126

Q8N1X5
GLAPAPTTIRDPEAG

UBAP1L

86

F5GYI3
FTELRGEIAGPPDTP

UBE2K

36

P61086
DPPFGGLVEPLAITF

ZCCHC4

276

Q9H5U6
ALVLEAGVAPPPTAG

SLC35E4

236

Q6ICL7
ATEAPGLIPSFTPGV

UBQLN2

466

Q9UHD9
DGEGPPPRVGFVDST

WNK2

1571

Q9Y3S1
EVLTPFPGLGTAAAP

WNT9B

31

O14905
FVGREESLSDGPPPR

TESK2

471

Q96S53
PPGLAREGDARTVPA

TSPY26P

16

Q9H489
PRLPAGAVVGIPASF

TMEM177

96

Q53S58
PFFIRGPSVEPGSIV

SULF1

341

Q8IWU6
PGGAFARVSDSIPPV

WASH6P

416

Q9NQA3
ELPDSAVGPGSREPL

WNK4

126

Q96J92
AVGPGSREPLRVPEA

WNK4

131

Q96J92
APLPEGDLPGQFTRV

SAMD4A

486

Q9UPU9
SAVPPQVGGRAFPED

SOCS6

251

O14544
RSEEPGAPLPVAVGT

SMTN

436

P53814
SVSAGLGEPRPPDVE

TMEM91

56

Q6ZNR0
QDGGPVGTELFRVPP

CX3CL1

176

P78423
GSGVPSELPQLIPVF

ZC3H7B

281

Q9UGR2
PGDFDVLPTGIPGRA

GARIN5B

561

Q8N5Q1
EVLFPESPARAGTEP

KMT2D

4816

O14686
RISPPLGDPEIGAAV

KCNH8

841

Q96L42
REDLVRDTPPGGPSS

NLRP12

91

P59046
VIVGSARARPPPDGT

RAB34

36

P0DI83
PSDLAGPVVAETRPG

MYOM1

1126

P52179
RPFVIVESPDPGTGG

GRIN2C

411

Q14957