Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	embryonic growth arrest	TMX2 SMG1 ZNF407 UBE2M ATE1 PTEN RNPC3	2.91e-05	346	37	7	MP:0001730
Domain	Homeobox_antennapedia	HOXC4 HOXD4	3.69e-04	12	45	2	IPR017995
Domain	Homeobox_Antennapedia_CS	HOXC4 HOXD4	1.16e-03	21	45	2	IPR001827
Domain	ANTENNAPEDIA	HOXC4 HOXD4	1.51e-03	24	45	2	PS00032
Domain	UBQ-conjugating_AS	UBE2M UBE2L6	1.64e-03	25	45	2	IPR023313
Domain	ZnF_U1	ZNF407 ZFHX3	2.21e-03	29	45	2	SM00451
Domain	Znf_U1	ZNF407 ZFHX3	2.21e-03	29	45	2	IPR003604
Domain	UQ_con	UBE2M UBE2L6	3.97e-03	39	45	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2M UBE2L6	4.18e-03	40	45	2	PS00183
Domain	UBIQUITIN_CONJUGAT_2	UBE2M UBE2L6	4.38e-03	41	45	2	PS50127
Domain	UBQ-conjugat_E2	UBE2M UBE2L6	4.38e-03	41	45	2	IPR000608
Pubmed	Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression.	PTEN EGFR	1.64e-06	2	45	2	15986432
Pubmed	Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR.	PTEN EGFR	1.64e-06	2	45	2	25870120
Pubmed	[Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors].	PTEN EGFR	1.64e-06	2	45	2	17236582
Pubmed	Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors.	PTEN EGFR	1.64e-06	2	45	2	23110505
Pubmed	Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles.	PTEN EGFR	1.64e-06	2	45	2	27823967
Pubmed	Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.	PTEN EGFR	1.64e-06	2	45	2	17646270
Pubmed	Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.	ZFHX3 PTEN	1.64e-06	2	45	2	26233892
Pubmed	Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation.	PTEN EGFR	1.64e-06	2	45	2	18240930
Pubmed	Inactivation of PTEN and ZFHX3 in Mammary Epithelial Cells Alters Patterns of Collective Cell Migration.	ZFHX3 PTEN	1.64e-06	2	45	2	36613756
Pubmed	The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.	PTPN13 PTEN	1.64e-06	2	45	2	29581186
Pubmed	PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.	PTPN13 PTEN	1.64e-06	2	45	2	25448478
Pubmed	Stromal PTEN determines mammary epithelial response to radiotherapy.	PTEN EGFR	1.64e-06	2	45	2	30018330
Pubmed	Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.	PTEN EGFR	1.64e-06	2	45	2	12743604
Pubmed	Phosphatidylinositol 3-kinase signaling determines kidney size.	PTEN EGFR	1.64e-06	2	45	2	25985273
Pubmed	Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.	PTEN EGFR	1.64e-06	2	45	2	19276385
Pubmed	PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors.	PTEN EGFR	1.64e-06	2	45	2	17255257
Pubmed	Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency.	PTEN EGFR	1.64e-06	2	45	2	23274758
Pubmed	Identification of CD28 and PTEN as novel prognostic markers for cervical cancer.	PTEN CD28	1.64e-06	2	45	2	30362552
Pubmed	The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.	SMG1 SMG8	1.64e-06	2	45	2	21245168
Pubmed	Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort.	PTEN EGFR	1.64e-06	2	45	2	17328268
Pubmed	Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas.	PTEN EGFR	1.64e-06	2	45	2	20208477
Pubmed	Cryo-EM structure of SMG1-SMG8-SMG9 complex.	SMG1 SMG8	4.91e-06	3	45	2	31729466
Pubmed	Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN.	PTEN EGFR	4.91e-06	3	45	2	26531778
Pubmed	EGFR, PIK3CA and PTEN gene status and their protein product expression in neuroblastic tumours.	PTEN EGFR	4.91e-06	3	45	2	21225506
Pubmed	PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation.	PTEN EGFR	4.91e-06	3	45	2	35240162
Pubmed	Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin.	PTEN EGFR	4.91e-06	3	45	2	22075159
Pubmed	Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.	PTEN EGFR	4.91e-06	3	45	2	16912159
Pubmed	EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal cancer treated with cetuximab.	PTEN EGFR	4.91e-06	3	45	2	24595598
Pubmed	InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex.	SMG1 SMG8	4.91e-06	3	45	2	31792449
Pubmed	Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms.	PTEN EGFR	4.91e-06	3	45	2	25808866
Pubmed	Difference in expression of EGFR, pAkt, and PTEN between oropharyngeal and oral cavity squamous cell carcinoma.	PTEN EGFR	4.91e-06	3	45	2	22682934
Pubmed	Radiogenomics to characterize regional genetic heterogeneity in glioblastoma.	PTEN EGFR	4.91e-06	3	45	2	27502248
Pubmed	Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer.	PTEN EGFR	4.91e-06	3	45	2	23242174
Pubmed	The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.	PTEN CD28	4.91e-06	3	45	2	11932928
Pubmed	Protein-structure-guided discovery of functional mutations across 19 cancer types.	PTEN EGFR	4.91e-06	3	45	2	27294619
Pubmed	FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence.	PTEN EGFR	4.91e-06	3	45	2	26653334
Pubmed	Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial tumor specimens.	PTEN EGFR	4.91e-06	3	45	2	19657395
Pubmed	Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.	PTEN EGFR	4.91e-06	3	45	2	23291982
Pubmed	EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.	EGFR ASH2L	4.91e-06	3	45	2	25996283
Pubmed	Matrine derivative WM130 inhibits hepatocellular carcinoma by suppressing EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways.	PTEN EGFR	4.91e-06	3	45	2	26259512
Pubmed	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.	PTEN EGFR	4.91e-06	3	45	2	37031335
Pubmed	PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.	PTEN EGFR	4.91e-06	3	45	2	11504770
Pubmed	PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression.	PTEN EGFR	4.91e-06	3	45	2	38499532
Pubmed	PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.	PTEN EGFR	4.91e-06	3	45	2	12517803
Pubmed	[Molecular mechanism of erlotinib resistance in epidermal growth factor receptor mutant non-small cell lung cancer cell line H1650].	PTEN EGFR	4.91e-06	3	45	2	23249714
Pubmed	Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy.	PTEN EGFR	4.91e-06	3	45	2	31122699
Pubmed	Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity.	SMG1 SMG8	4.91e-06	3	45	2	32469312
Pubmed	Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR.	PTEN EGFR	4.91e-06	3	45	2	19763916
Pubmed	MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol.	PTEN EGFR	4.91e-06	3	45	2	20113523
Pubmed	Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer.	PTEN EGFR	4.91e-06	3	45	2	25454348
Pubmed	Comparative study of HER2, EGFR, p53 and PTEN expression in the human gastrointestinal tract during fetal period.	PTEN EGFR	9.81e-06	4	45	2	26193216
Pubmed	HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies.	PTEN EGFR	9.81e-06	4	45	2	26853466
Pubmed	The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.	PTEN EGFR	9.81e-06	4	45	2	20308550
Pubmed	Clinicopathological significance of PTEN and PI3K/AKT signal transduction pathway in non-small cell lung cancer.	PTEN EGFR	9.81e-06	4	45	2	24133589
Pubmed	PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.	PTEN EGFR	9.81e-06	4	45	2	20018398
Pubmed	SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.	PTEN EGFR	9.81e-06	4	45	2	22649008
Pubmed	Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation.	PTEN EGFR	9.81e-06	4	45	2	31318186
Pubmed	Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.	PTEN EGFR	9.81e-06	4	45	2	33323972
Pubmed	Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.	PTEN EGFR	9.81e-06	4	45	2	19196966
Pubmed	Targeting the cyclin-dependent kinase 5 in metastatic melanoma.	PTEN CDK5	9.81e-06	4	45	2	32193336
Pubmed	Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.	PTEN EGFR	9.81e-06	4	45	2	19884556
Pubmed	Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma.	PTEN EGFR	9.81e-06	4	45	2	24115218
Pubmed	Correlation of chromosomal imbalances by comparative genomic hybridization and expression of EGFR, PTEN, p53, and MIB-1 in diffuse gliomas.	PTEN EGFR	9.81e-06	4	45	2	17390041
Pubmed	Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.	PTEN EGFR	1.63e-05	5	45	2	25051360
Pubmed	EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells.	EGFR CDK5	1.63e-05	5	45	2	24091658
Pubmed	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.	SMG1 SMG8	1.63e-05	5	45	2	26841701
Pubmed	PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.	PTEN EGFR	2.45e-05	6	45	2	16456542
Pubmed	Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.	PTEN EGFR	2.45e-05	6	45	2	27165742
Pubmed	Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.	SMG1 SMG8	2.45e-05	6	45	2	33205750
Pubmed	Comparative characteristics of genetic aberrations in glioblastomas in children and adults.	PTEN EGFR	2.45e-05	6	45	2	25033601
Pubmed	Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.	ZFHX3 PTPN13	3.42e-05	7	45	2	29093530
Pubmed	Sequence and embryonic expression of the murine Hox-3.5 gene.	HOXC4 HOXD4	3.42e-05	7	45	2	1363091
Pubmed	Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.	HOXC4 HOXD4	3.42e-05	7	45	2	8660891
Pubmed	Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.	CFH CD28	3.42e-05	7	45	2	10693874
Pubmed	Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP.	NR4A2 PTEN	3.42e-05	7	45	2	28831020
Pubmed	Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.	UBE2M EGFR	3.42e-05	7	45	2	16735510
Pubmed	The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.	HOXC4 HOXD4	4.56e-05	8	45	2	11279128
Pubmed	Hox genes regulate the onset of Tbx5 expression in the forelimb.	HOXC4 HOXD4	4.56e-05	8	45	2	22872086
Pubmed	Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.	PTEN EGFR	4.56e-05	8	45	2	20534535
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	SMG1 SMG8 NOL9 PTEN	5.42e-05	159	45	4	30581152
Pubmed	Region-specific gastrointestinal Hox code during murine embryonal gut development.	HOXC4 HOXD4	5.86e-05	9	45	2	11869294
Pubmed	Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.	HOXC4 HOXD4	5.86e-05	9	45	2	10579975
Pubmed	Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.	PTEN EGFR	7.32e-05	10	45	2	20881644
Pubmed	Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL.	PTEN EGFR	8.94e-05	11	45	2	34831026
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PTEN CD28	1.07e-04	12	45	2	12077252
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXC4 HOXD4	1.07e-04	12	45	2	8105001
Pubmed	The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.	HOXC4 HOXD4	1.27e-04	13	45	2	8887324
Pubmed	Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.	CFH SMG8	1.47e-04	14	45	2	23620142
Pubmed	The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies.	PTEN EGFR GLIS2	1.55e-04	80	45	3	28205554
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXC4 HOXD4	1.70e-04	15	45	2	1682814
Pubmed	Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.	PTEN EGFR	1.70e-04	15	45	2	22094257
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	NR4A2 FZD8	1.70e-04	15	45	2	18255031
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 SMG8 NOL9 ASH2L RSPRY1 RALGAPB	1.82e-04	650	45	6	38777146
Pubmed	Nipbl and mediator cooperatively regulate gene expression to control limb development.	HOXC4 HOXD4	1.94e-04	16	45	2	25255084
Pubmed	Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons.	EGFR CDK5	1.94e-04	16	45	2	24142862
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	TMX2 ZNF407 UBE2M PTEN LYST	3.04e-04	457	45	5	32968282
Pubmed	SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.	SMG1 SMG8	3.06e-04	20	45	2	19417104
Pubmed	The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.	HOXC4 HOXD4	3.06e-04	20	45	2	12370779
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	HOXC4 HOXD4 MYT1 GLIS2	3.13e-04	251	45	4	29031500
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	HOXC4 HOXD4	3.38e-04	21	45	2	30254164
Cytoband	5q32	SPINK13 HMGXB3	1.30e-03	54	45	2	5q32
Cytoband	Ensembl 112 genes in cytogenetic band chr5q32	SPINK13 HMGXB3	2.83e-03	80	45	2	chr5q32
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2M UBE2L6	2.53e-03	41	33	2	102
GeneFamily	HOXL subclass homeoboxes	HOXC4 HOXD4	4.05e-03	52	33	2	518
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NR4A2 HOXD4 EGFR CD28	2.20e-05	163	45	4	240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	NR4A2 CFH ZFHX3 EGFR	4.26e-05	193	45	4	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	CFH ZFHX3 PTEN EGFR	4.44e-05	195	45	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 CD28 RNPC3	4.62e-05	197	45	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Bronchial-NucSeq-Stromal-Peri/Epineurial_\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NR4A2 CFH PTPN13 EGFR	4.62e-05	197	45	4	ee8f7def9d5af7b1e636830a4ea1da158d02f25a
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 ZNF407 RNPC3	4.80e-05	199	45	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH PTPN13 EGFR AHNAK2	4.80e-05	199	45	4	ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	NR4A2 SMG1 UBE2L6 LYST	4.89e-05	200	45	4	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFH PTPN13 EGFR AHNAK2	4.89e-05	200	45	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	droplet-Fat-Scat-18m-Hematologic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2L6 PP2D1 GABRA4	7.55e-05	81	45	3	9a1cc6da6b7e697159a857c0dfe6e2a494160f9c
ToppCell	droplet-Fat-Scat-18m-Hematologic-erythroblast\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2L6 PP2D1 GABRA4	7.55e-05	81	45	3	40981efef1b79adaa08fd20cf87955d0ae973ca7
ToppCell	droplet-Fat-Scat-18m-Hematologic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2L6 PP2D1 GABRA4	7.55e-05	81	45	3	98ee7f5a66dc29c9563cabea8160f118bcbbde73
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN13 UBE2L6 GABRA4	5.21e-04	156	45	3	5caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN13 UBE2L6 GABRA4	5.21e-04	156	45	3	758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PTPN13 EGFR PANK1	5.51e-04	159	45	3	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	URO-Lymphocyte-T_NK-CD4_TEM\|URO / Disease, Lineage and Cell Type	CFH ST8SIA5 CD28	5.61e-04	160	45	3	e406f77b1c1a01d74f39ba65f99d5f8c7d75faf1
ToppCell	COVID-19_Moderate-MAIT\|World / disease group, cell group and cell class	CFH PTPN13 CD28	5.61e-04	160	45	3	bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCell	droplet-Marrow-BM-30m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ZFHX3 UBE2L6	5.61e-04	160	45	3	822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PTPN13 CD28	5.72e-04	161	45	3	140b3c7077947c541cff54f6754e2df968345f4d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 CD28	5.72e-04	161	45	3	580153e131247e6ec12a1a920f050a0a763e7e87
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 SMG1 CD28	5.82e-04	162	45	3	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PTPN13 CD28	5.82e-04	162	45	3	16f9fbcaa0093ffc5a2a5e32db6040e2cb519d47
ToppCell	droplet-Marrow-BM-30m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ZFHX3 UBE2L6	5.82e-04	162	45	3	76e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH FZD8 PTPN13	6.03e-04	164	45	3	8f3255d7f67890389a768453492243ea982eb38a
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VPS13D UBE2L6 LYST	6.03e-04	164	45	3	f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR4A2 CFH ZFHX3	6.14e-04	165	45	3	1121f78574b9fe64d966b7f8c9cbc4d59e9b6e5e
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR4A2 CFH ZFHX3	6.14e-04	165	45	3	fee7f2f8d0e25c0d067adc73f8913721bd709a3e
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VPS13D FMO3 EGFR	6.25e-04	166	45	3	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR4A2 CFH ZFHX3	6.25e-04	166	45	3	739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH HOXC4 AHNAK2	6.36e-04	167	45	3	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR4A2 CFH ZFHX3	6.36e-04	167	45	3	a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXC4 PTPN13 GABRA4	6.36e-04	167	45	3	e1b1a952fce27ab9cf16919b290625ff4a75261e
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH HOXC4 AHNAK2	6.36e-04	167	45	3	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NR4A2 CFH ZFHX3	6.58e-04	169	45	3	0c341f91dc21aaf92bead18d59684d11510502ce
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	EGFR PANK1 AHNAK2	6.58e-04	169	45	3	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH PTPN13 CD28	6.58e-04	169	45	3	3ad534303b4b60a77d171e605a1ba2ef20b5e2a3
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FZD8 ZNF407 KIAA1586	6.58e-04	169	45	3	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH PTPN13 CD28	6.58e-04	169	45	3	29dca061864c86218ab73a86cf6e3c522472da47
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FZD8 ZNF407 KIAA1586	6.58e-04	169	45	3	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	6.58e-04	169	45	3	a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH EGFR AHNAK2	6.69e-04	170	45	3	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Regulatory_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN13 PP2D1 CD28	6.69e-04	170	45	3	064786c1f1ad7665358964765910b0ad46d14685
ToppCell	droplet-Lung-nan-18m-Lymphocytic-regulatory_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPN13 PP2D1 CD28	6.69e-04	170	45	3	6725747df336697708b94999b3ebb40f1721da16
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 PP2D1	6.69e-04	170	45	3	51dbfa07daf6f972b566f3f6abe7f46e080ec01c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH EGFR AHNAK2	6.69e-04	170	45	3	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN13 PP2D1 CD28	6.81e-04	171	45	3	7c0a1b0676f6749ee710c6bdeca6d6f7fac79b69
ToppCell	wk_20-22-Mesenchymal-Chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFH FZD8 ZFHX3	6.81e-04	171	45	3	d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SMG1 ZNF407 CD28	6.81e-04	171	45	3	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	Healthy/Control-MAIT\|World / Disease group and Cell class	NR4A2 CFH CD28	6.81e-04	171	45	3	61515114b17816a8f9ef6a57262eb9e977b6ede4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PTPN13 PP2D1 CD28	6.81e-04	171	45	3	10492832db8ebc3cf85503c441f33bd94df9458e
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH EGFR GABRA4	6.92e-04	172	45	3	bd01b39a5699824ab14827cc9dc98e547d65b160
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH EGFR GABRA4	7.16e-04	174	45	3	911eac6f6ec1e5e85348a7fe774243498388a810
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH PTPN13 EGFR	7.16e-04	174	45	3	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NR4A2 SMG8 CD28	7.28e-04	175	45	3	f456d8d958b71f7a942b718605712593d9de1bfd
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Dedifferentiated_Liposarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	CFH CD28 GBGT1	7.28e-04	175	45	3	2eca4c168dea2017ea0e383006e28abed22f32ec
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FAM149B1 NOL9 CD28	7.28e-04	175	45	3	a3f8c54c77bce9b035a4835945ab341909be4946
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PTPN13 CD28	7.40e-04	176	45	3	e2b4be7d4f31a78d7862c0fd629dd9cc84589193
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PTPN13 CD28	7.40e-04	176	45	3	299075e65ca86564e1c0b06058bd4371a60a3bcd
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	SMG1 ZNF407 LYST	7.40e-04	176	45	3	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-erythroid_macrophage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EGFR CD28 MYT1	7.52e-04	177	45	3	b647667da62a91dbe3890820142626e26aa779d2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	7.52e-04	177	45	3	b872ee91e01265b101b81bd304cf6b95d5419e68
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	SMG1 ZNF407 LYST	7.52e-04	177	45	3	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	FZD8 ST8SIA5 MYT1	7.65e-04	178	45	3	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	facs-Heart-RA-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2M PTEN CD28	7.65e-04	178	45	3	b505e2550860e777535ee95f29c936242fd607f1
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH FZD8 AHNAK2	7.65e-04	178	45	3	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	7.65e-04	178	45	3	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	T_cells-TFH-like_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ZC3H12C PTPN13 CD28	7.65e-04	178	45	3	e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFH PTPN13 EGFR	7.65e-04	178	45	3	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	7.65e-04	178	45	3	78a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-MAIT_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMGXB3 FAM149B1 LYST	7.65e-04	178	45	3	0290868dc990878eac5c182fe64968333bc52450
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ST8SIA5 ZC3H12C MYT1	7.77e-04	179	45	3	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTPN13 PANK1 CD28	7.77e-04	179	45	3	35f014b6e752626909d829c5ab9bb761c1f3e3dc
ToppCell	BAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PTPN13 PANK1 CD28	7.77e-04	179	45	3	a634ca46ffc394c5f5215fc5d8eae4a77819af9c
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Trm_Th1/Th17\|GI_large-bowel / Manually curated celltypes from each tissue	CFH PTPN13 CD28	7.77e-04	179	45	3	6359f30005b17dc5b5c4c8f3a6a38c87ccfe4ee9
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l4\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NR4A2 PTPN13 CD28	8.02e-04	181	45	3	a2c03bd7adc4a65f3b373c229ec0ecc84f724b17
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-mature_NK_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NR4A2 PTPN13 CD28	8.02e-04	181	45	3	c073e6c917354528ac5bad88a226e1134004ba43
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 SMG1 CD28	8.02e-04	181	45	3	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTR1B ZC3H12C RSPRY1	8.02e-04	181	45	3	709e9c7a60d5f98635b99895ce30bb87a9f7376d
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 LYST CD28	8.15e-04	182	45	3	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	Control-Epithelial-Basal\|Control / Disease state, Lineage and Cell class	CFH PTPN13 EGFR	8.15e-04	182	45	3	caddd0a52f0234ea6a916186ffaf2454cdcd80ee
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 LYST CD28	8.15e-04	182	45	3	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	8.42e-04	184	45	3	c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPN13 EGFR AHNAK2	8.55e-04	185	45	3	e0172e0ab0f1d7151a3c3c63bb7c84d6bda92035
ToppCell	PBMC-Mild-cDC_8\|Mild / Compartment, Disease Groups and Clusters	NR4A2 UBE2M UBE2L6	8.55e-04	185	45	3	891b39c20fe9858fbba90d9ef7a253f1a0870211
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 CD28	8.55e-04	185	45	3	e34473eea3a58c041183a4f52137366cd9489495
ToppCell	Mild-CD4+_T\|Mild / Disease group and Cell class	CFH PTPN13 CD28	8.55e-04	185	45	3	c28ecb63146de1b02418e5a4fad0ae7c2b66a41d
ToppCell	droplet-Liver-LIVER-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 PTPN13 CD28	8.68e-04	186	45	3	ad55da1dbb173721101126826b6db9d3434cb377
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	USP34 SMG1 VPS13D	8.68e-04	186	45	3	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMO3 HOXD4 GABRA4	8.82e-04	187	45	3	150023e6a50c9da461f2321074d2d5e96caafb06
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NR4A2 CFH PTPN13	8.82e-04	187	45	3	f1ba41f2ec703251a81c46e08d45e70210f298e7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 CD28	8.82e-04	187	45	3	e1d6c1194476cf26969e405b0951796fed519f44
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c07-AHNAK\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 CD28	8.95e-04	188	45	3	3e3055dacc05a932f2beb114babf1dc76994e1af
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 SMG1 ZNF407	8.95e-04	188	45	3	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CFH PTPN13 CD28	8.95e-04	188	45	3	fe08277d5aa693a2e12786738d12ec6390e8d13d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	9.09e-04	189	45	3	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	9.09e-04	189	45	3	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	(1)_T_CD8_gd\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	NR4A2 CFH LYST	9.09e-04	189	45	3	62eda4bcfd21d5025ac676d524994ede22721c1d
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	ZFHX3 ST8SIA5 MYT1	9.23e-04	190	45	3	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CFH FMO3 PTEN	9.37e-04	191	45	3	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	CFH ZFHX3 EGFR	9.37e-04	191	45	3	70c067c54084bfb02c29bab085f4defd477194fb
Computational	Neighborhood of MSH3	CFH SMG1 PTEN HOXD4 GLE1	5.09e-04	243	30	5	MORF_MSH3
Computational	Neighborhood of FOSL1	CFH SMG1 PTEN HOXD4 GLE1 MYT1	7.68e-04	406	30	6	MORF_FOSL1
Computational	Neighborhood of PSMF1	SMG1 PTEN HOXD4 GLE1	1.12e-03	167	30	4	MORF_PSMF1
Computational	Neighborhood of ESR1	CFH SMG1 HOXD4 GLE1	1.25e-03	172	30	4	MORF_ESR1
Computational	Neighborhood of MLLT10	CFH PTEN HOXD4 GLE1 MYT1	1.35e-03	302	30	5	MORF_MLLT10
Computational	Genes in the cancer module 4.	UBE2M UBE2L6	1.53e-03	21	30	2	MODULE_4
Computational	Genes in the cancer module 233.	UBE2M UBE2L6	1.68e-03	22	30	2	MODULE_233
Drug	azathioprine, USP; Down 200; 100uM; MCF7; HG-U133A	NR4A2 USP34 VPS13D LYST CD28 GABRA4	2.28e-06	200	44	6	338_DN
Disease	lung adenocarcinoma (is_implicated_in)	ZFHX3 PTPN13 EGFR	5.07e-05	49	43	3	DOID:3910 (is_implicated_in)
Disease	Malignant tumor of prostate	ZFHX3 PTEN	7.42e-05	9	43	2	cv:C0376358
Disease	oral squamous cell carcinoma (is_marker_for)	PTPN13 PTEN EGFR	1.08e-04	63	43	3	DOID:0050866 (is_marker_for)
Disease	Polyposis, Adenomatous Intestinal	FMO3 EGFR	2.46e-04	16	43	2	C2713442
Disease	Familial Intestinal Polyposis	FMO3 EGFR	2.46e-04	16	43	2	C2713443
Disease	Adenomatous Polyposis Coli	FMO3 EGFR	2.78e-04	17	43	2	C0032580
Disease	Malignant neoplasm of endometrium	PTEN EGFR	3.13e-04	18	43	2	C0007103
Disease	Carcinoma in situ of endometrium	PTEN EGFR	3.13e-04	18	43	2	C0346191
Disease	leukemia (implicated_via_orthology)	HOXC4 HOXD4	3.49e-04	19	43	2	DOID:1240 (implicated_via_orthology)
Disease	Adenocarcinoma of prostate	PTEN EGFR	3.88e-04	20	43	2	C0007112
Disease	Carcinoma of lung	PTEN EGFR	5.15e-04	23	43	2	C0684249
Disease	Neoplasm of the genitourinary tract	ZFHX3 PTEN	5.61e-04	24	43	2	cv:C0042065
Disease	Intrahepatic Cholangiocarcinoma	PTEN EGFR	5.61e-04	24	43	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	PTEN EGFR	5.61e-04	24	43	2	C3805278
Disease	Cholangiocarcinoma	PTEN EGFR	6.59e-04	26	43	2	C0206698
Disease	myeloperoxidase measurement	CFH SMG8	6.59e-04	26	43	2	EFO_0005243
Disease	prostate cancer (is_implicated_in)	ZFHX3 PTEN EGFR	6.68e-04	117	43	3	DOID:10283 (is_implicated_in)
Disease	Sezary Syndrome	PTEN CD28	7.11e-04	27	43	2	C0036920
Disease	Chloracne	EGFR CD28	1.06e-03	33	43	2	C0263454
Disease	lung non-small cell carcinoma (is_implicated_in)	ZFHX3 PTEN EGFR	1.10e-03	139	43	3	DOID:3908 (is_implicated_in)
Disease	Parkinsonism (biomarker_via_orthology)	NR4A2 EGFR	1.13e-03	34	43	2	DOID:0080855 (biomarker_via_orthology)
Disease	Malignant neoplasm of brain	PTEN EGFR	1.41e-03	38	43	2	C0153633

Protein segments in the cluster

Peptide	Gene	Start	Entry
FCKIEVMYPPPYLDN	CD28	111	P10747
YLKDYKPTCMLNIPF	ADAM7	381	Q9H2U9
TKLPDYKPYPMYPAT	CDK5	231	Q00535
PKYCFPNYVGRPKHM	ACTR1B	31	P42025
KKCPYSVPFYPTFKE	GLE1	526	Q53GS7
EYYCNPRFLMKGPNK	CFH	656	P08603
CFKYPPKDLTYRPMS	ASH2L	581	Q9UBL3
KPRCKMYIPLDPDYN	SPINK13	36	Q1W4C9
RTPQKMVYYGKPSCK	NOL9	366	Q5SY16
KLAMEVYFGPCSPYQ	FMO3	456	P31513
KPDMFPPYKYSCTVT	HMGXB3	596	Q12766
PSAYYSDILFPKMPK	KIAA1586	56	Q9HCI6
CPLKFGSYAYPKSEM	GABRA4	186	P48169
THYVDKPYYCKMPGC	GLIS2	286	Q9BZE0
YMVNSKYVDPKFPPC	HOXD4	6	P09016
MYTPICLEDYKKPLP	FZD8	91	Q9H461
KDTCPPLMLYNPTTY	EGFR	261	P00533
VPYYLPCPEIFNMKL	GBGT1	36	Q8N5D6
YLMDSNYIDPKFPPC	HOXC4	6	P09017
VMPCKYGKPVNDYSK	LYST	1696	Q99698
MKYKGQYRPSDLLCP	ATE1	416	O95260
GVIPYFPYSKQCKMR	PRPSAP2	106	O60256
YIFKPCQSALYMPVP	KRTAP29-1	211	A8MX34
TMFYYPQKIPNKPEF	PTPN13	1706	Q12923
DKFMYFEFPQPLPVC	PTEN	236	P60484
LCQKKPYCLDNPYPM	PANK1	396	Q8TE04
GYPPIAPFYCMKEDV	FAM149B1	256	Q96BN6
YDVKPPCLYQMPLSG	NR4A2	71	P43354
PCFPPKENVQLMSYK	SMG8	966	Q8ND04
KPFKYPPSMKFSTFN	RSPRY1	481	Q96DX4
KYEMQYAPQPPPTVC	SMG1	2686	Q96Q15
PKDMPYYRSQFKKCA	ST8SIA5	151	O15466
YKPKFVFSVPQMAVP	AHNAK2	4866	Q8IVF2
TCKPPLYMGPEYIKY	TMX2	126	Q9Y320
FPLNSCLKYMYPPPS	RNPC3	151	Q96LT9
YPFKPPMIKFTTKIY	UBE2L6	61	O14933
PCRPFDTVFIFYMKP	RALGAPB	1156	Q86X10
TPMPYEQYPKCDSPV	ZC3H12C	571	Q9C0D7
KMYNCPKCDYGTNVP	ZNF407	1771	Q9C0G0
NPRPFCKTYTMDKQP	USP34	1956	Q70CQ2
YPHDPPKVKCETMVY	UBE2M	86	P61081
EIKPEQMYQCPYCKY	ZFHX3	1216	Q15911
MYKETYCPIIPNKSP	PP2D1	476	A8MPX8
CVAIKKENYPDYMPS	VPS13D	3146	Q5THJ4
MCFVKQLEVPPYGSY	MYT1	546	Q01538