Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR1 TLR6	9.23e-05	4	79	2	GO:0035663
GeneOntologyMolecularFunction	steroid hormone binding	ATP1A1 ATP1A3	3.20e-04	7	79	2	GO:1990239
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP2C2 ATP1A1 ATP1A3	3.87e-04	36	79	3	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP2C2 ATP1A1 ATP1A3	3.87e-04	36	79	3	GO:0015662
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A1 ATP1A3	6.81e-04	10	79	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A1 ATP1A3	6.81e-04	10	79	2	GO:0005391
GeneOntologyMolecularFunction	lipopeptide binding	TLR1 TLR6	6.81e-04	10	79	2	GO:0071723
GeneOntologyMolecularFunction	ATP-dependent activity	DNHD1 MYO9A ATP2C2 WRN ATP1A1 ATP1A3 POLQ DNAH9 KIF24	7.02e-04	614	79	9	GO:0140657
GeneOntologyMolecularFunction	amyloid-beta binding	AGER GRIN2A TLR6 ATP1A3	7.19e-04	102	79	4	GO:0001540
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A1 ATP1A3	8.31e-04	11	79	2	GO:0008556
GeneOntologyMolecularFunction	amide binding	ACADM AGER TLR1 GRIN2A TLR6 ATP1A3	1.19e-03	299	79	6	GO:0033218
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 MYO9A DNAH9 KIF24	1.24e-03	118	79	4	GO:0003774
GeneOntologyBiologicalProcess	cellular response to amyloid-beta	AGER GRIN2A TLR6 ATP1A3	3.70e-05	49	79	4	GO:1904646
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR1 TLR6	4.33e-05	3	79	2	GO:0070340
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR1 TLR6	8.65e-05	4	79	2	GO:0042494
GeneOntologyBiologicalProcess	response to amyloid-beta	AGER GRIN2A TLR6 ATP1A3	8.81e-05	61	79	4	GO:1904645
GeneOntologyCellularComponent	photoreceptor inner segment membrane	ATP1A1 ATP1A3	8.64e-05	4	80	2	GO:0060342
Domain	RHOGAP	MYO9A SH3BP1 ARHGAP29 DEPDC1 ARHGAP33	7.47e-06	64	79	5	PS50238
Domain	RhoGAP_dom	MYO9A SH3BP1 ARHGAP29 DEPDC1 ARHGAP33	7.47e-06	64	79	5	IPR000198
Domain	-	MYO9A SH3BP1 ARHGAP29 DEPDC1 ARHGAP33	7.47e-06	64	79	5	1.10.555.10
Domain	Rho_GTPase_activation_prot	MYO9A SH3BP1 ARHGAP29 DEPDC1 ARHGAP33	3.55e-05	88	79	5	IPR008936
Domain	-	ATP2C2 ATP1A1 ATP1A3	3.92e-05	16	79	3	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2C2 ATP1A1 ATP1A3	3.92e-05	16	79	3	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2C2 ATP1A1 ATP1A3	4.75e-05	17	79	3	IPR006068
Domain	Cation_ATPase_C	ATP2C2 ATP1A1 ATP1A3	4.75e-05	17	79	3	PF00689
Domain	Cation_ATPase_N	ATP2C2 ATP1A1 ATP1A3	5.68e-05	18	79	3	PF00690
Domain	Cation_ATPase_N	ATP2C2 ATP1A1 ATP1A3	5.68e-05	18	79	3	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2C2 ATP1A1 ATP1A3	6.72e-05	19	79	3	IPR004014
Domain	RhoGAP	MYO9A SH3BP1 ARHGAP29 ARHGAP33	1.37e-04	62	79	4	SM00324
Domain	RhoGAP	MYO9A SH3BP1 ARHGAP29 ARHGAP33	1.46e-04	63	79	4	PF00620
Domain	Toll-like_receptor	TLR1 TLR6	1.75e-04	5	79	2	IPR017241
Domain	P-type_ATPase_IIC	ATP1A1 ATP1A3	2.62e-04	6	79	2	IPR005775
Domain	ATPase_P-typ_cyto_domN	ATP2C2 ATP1A1 ATP1A3	4.32e-04	35	79	3	IPR023299
Domain	P_typ_ATPase	ATP2C2 ATP1A1 ATP1A3	4.70e-04	36	79	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP2C2 ATP1A1 ATP1A3	4.70e-04	36	79	3	IPR018303
Domain	ATPASE_E1_E2	ATP2C2 ATP1A1 ATP1A3	4.70e-04	36	79	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2C2 ATP1A1 ATP1A3	5.10e-04	37	79	3	IPR008250
Domain	E1-E2_ATPase	ATP2C2 ATP1A1 ATP1A3	5.10e-04	37	79	3	PF00122
Domain	Dynein_HC_stalk	DNHD1 DNAH9	1.56e-03	14	79	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH9	1.56e-03	14	79	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH9	1.56e-03	14	79	2	PF08393
Domain	MT	DNHD1 DNAH9	1.56e-03	14	79	2	PF12777
Domain	DHC_fam	DNHD1 DNAH9	1.79e-03	15	79	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH9	1.79e-03	15	79	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH9	1.79e-03	15	79	2	PF03028
Domain	TIR	TLR1 TLR6	3.52e-03	21	79	2	SM00255
Domain	TIR	TLR1 TLR6	3.86e-03	22	79	2	PF01582
Domain	-	TLR1 TLR6	4.22e-03	23	79	2	3.40.50.10140
Domain	HAD-like_dom	ATP2C2 ATP1A1 ATP1A3	4.57e-03	79	79	3	IPR023214
Domain	TIR	TLR1 TLR6	4.59e-03	24	79	2	PS50104
Pubmed	Na,K-ATPase expression in the mouse cochlea is not dependent on the mineralocorticoid receptor.	NR3C2 ATP1A1 ATP1A3	4.68e-08	4	80	3	11591489
Pubmed	Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes.	CP TF	5.23e-06	2	80	2	3436225
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR1 TLR6	5.23e-06	2	80	2	22315281
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR1 TLR6	5.23e-06	2	80	2	18036178
Pubmed	Rage signalling promotes intestinal tumourigenesis.	AGER APC	5.23e-06	2	80	2	22469986
Pubmed	Immunohistochemical analyses of alpha1 and alpha3 Na+/K+-ATPase subunit expression in medulloblastomas.	ATP1A1 ATP1A3	5.23e-06	2	80	2	21498719
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR1 TLR6	5.23e-06	2	80	2	24445834
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR1 TLR6	5.23e-06	2	80	2	26470427
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR1 TLR6	5.23e-06	2	80	2	21852947
Pubmed	Arctigenin antagonizes mineralocorticoid receptor to inhibit the transcription of Na/K-ATPase.	NR3C2 ATP1A1	5.23e-06	2	80	2	26446917
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR1 TLR6	5.23e-06	2	80	2	24984237
Pubmed	Ceruloplasmin/Transferrin system is related to clinical status in acute stroke.	CP TF	5.23e-06	2	80	2	19228837
Pubmed	Hypertension increases urinary excretion of immunoglobulin G, ceruloplasmin and transferrin in normoalbuminuric patients with type 2 diabetes mellitus.	CP TF	5.23e-06	2	80	2	24256706
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR1 TLR6	5.23e-06	2	80	2	11123271
Pubmed	All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.	ATP1A1 ATP1A3	5.23e-06	2	80	2	11546672
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR1 TLR6	5.23e-06	2	80	2	25261617
Pubmed	Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.	CP TF	5.23e-06	2	80	2	29079528
Pubmed	Properties and expression of Na+/K+-ATPase α-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance.	ATP1A1 ATP1A3	5.23e-06	2	80	2	24391932
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR1 TLR6	5.23e-06	2	80	2	29175392
Pubmed	Increased urinary excretions of immunoglobulin g, ceruloplasmin, and transferrin predict development of microalbuminuria in patients with type 2 diabetes.	CP TF	5.23e-06	2	80	2	16373913
Pubmed	The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis.	DNAJA3 APC	5.23e-06	2	80	2	19900451
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR1 TLR6	5.23e-06	2	80	2	28474755
Pubmed	Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.	ATP1A1 ATP1A3	5.23e-06	2	80	2	23761886
Pubmed	Diurnal changes in urinary excretion of IgG, transferrin, and ceruloplasmin depend on diurnal changes in systemic blood pressure in normotensive, normoalbuminuric type 2 diabetic patients.	CP TF	5.23e-06	2	80	2	19670106
Pubmed	The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit.	ATP1A1 ATP1A3	5.23e-06	2	80	2	3030810
Pubmed	Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation.	POSTN APC	5.23e-06	2	80	2	31968254
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR1 TLR6	5.23e-06	2	80	2	22778390
Pubmed	Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.	ATP1A1 ATP1A3	1.57e-05	3	80	2	2822726
Pubmed	Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.	ATP1A1 ATP1A3	1.57e-05	3	80	2	30819023
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR1 TLR6	1.57e-05	3	80	2	16081826
Pubmed	DEPDC1 drives hepatocellular carcinoma cell proliferation, invasion and angiogenesis by regulating the CCL20/CCR6 signaling pathway.	CCR6 DEPDC1	1.57e-05	3	80	2	31322256
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR1 TLR6	1.57e-05	3	80	2	18752252
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR1 TLR6	1.57e-05	3	80	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR1 TLR6	1.57e-05	3	80	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR1 TLR6	1.57e-05	3	80	2	25246533
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR1 TLR6	1.57e-05	3	80	2	11095740
Pubmed	Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.	ATP1A1 ATP1A3	1.57e-05	3	80	2	27836549
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A1 ATP1A3	1.57e-05	3	80	2	26373354
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR6	1.57e-05	3	80	2	11607792
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR1 TLR6	1.57e-05	3	80	2	25850295
Pubmed	Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.	ATP1A1 ATP1A3	1.57e-05	3	80	2	17947306
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR1 TLR6	1.57e-05	3	80	2	18451040
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR1 TLR6	1.57e-05	3	80	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR1 TLR6	1.57e-05	3	80	2	24922103
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR1 TLR6	1.57e-05	3	80	2	24683188
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR1 TLR6	1.57e-05	3	80	2	16177110
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR1 TLR6	1.57e-05	3	80	2	22150367
Pubmed	Levels of antioxidant proteins and soluble intercellular adhesion molecule-1 in serum of patients with rheumatoid arthritis.	CP TF	1.57e-05	3	80	2	12175089
Pubmed	Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.	TLR1 TLR6	1.57e-05	3	80	2	30028533
Pubmed	Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.	ATP1A1 ATP1A3	1.57e-05	3	80	2	19058785
Pubmed	Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients.	CP TF	1.57e-05	3	80	2	30359420
Pubmed	Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.	ATP1A1 ATP1A3	1.57e-05	3	80	2	28465228
Pubmed	Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.	TLR1 TLR6	1.57e-05	3	80	2	19931471
Pubmed	Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.	ATP1A1 ATP1A3	1.57e-05	3	80	2	8203495
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR1 TLR6	1.57e-05	3	80	2	23626692
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR1 TLR6	1.57e-05	3	80	2	15812078
Pubmed	Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients.	CP TF	1.57e-05	3	80	2	15111541
Pubmed	Na,K-ATPase and the role of alpha isoforms in behavior.	ATP1A1 ATP1A3	1.57e-05	3	80	2	18044013
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR1 TLR6	1.57e-05	3	80	2	28123183
Pubmed	Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.	ATP1A1 ATP1A3	1.57e-05	3	80	2	26988030
Pubmed	Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.	TLR1 TLR6	1.57e-05	3	80	2	22822027
Pubmed	TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.	TLR1 TLR6	1.57e-05	3	80	2	24511099
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR1 TLR6	1.57e-05	3	80	2	18091991
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR1 TLR6	1.57e-05	3	80	2	16461792
Pubmed	GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.	APC ATP1A1	1.57e-05	3	80	2	30600262
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR1 TLR6	1.57e-05	3	80	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR1 TLR6	1.57e-05	3	80	2	14966134
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR1 TLR6	1.57e-05	3	80	2	17932345
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR1 TLR6	1.57e-05	3	80	2	24112285
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR1 TLR6	1.57e-05	3	80	2	23151486
Pubmed	Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.	ATP1A1 ATP1A3	1.57e-05	3	80	2	26911348
Pubmed	Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.	CP TF	1.57e-05	3	80	2	18022819
Pubmed	The effect of occupational lead exposure on blood levels of zinc, iron, copper, selenium and related proteins.	CP TF	1.57e-05	3	80	2	22923205
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR1 TLR6	1.57e-05	3	80	2	12077222
Pubmed	CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.	APC CCR6	1.57e-05	3	80	2	24866282
Pubmed	Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.	TLR1 TLR6	1.57e-05	3	80	2	17595379
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR1 TLR6	1.57e-05	3	80	2	18056480
Pubmed	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	TLR1 TLR6	1.57e-05	3	80	2	16374251
Pubmed	Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.	ATP1A1 ATP1A3	1.57e-05	3	80	2	25994790
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR1 TLR6	1.57e-05	3	80	2	21998742
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR1 TLR6	1.57e-05	3	80	2	22280448
Pubmed	Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation.	APC ATP1A3	1.57e-05	3	80	2	17234755
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CSDE1 PTPRA MYO9A APC EWSR1 GRIN2A ATP1A1 ATP1A3 PLCH1 TF SLC39A7 PDLIM5 ARCN1	2.22e-05	1431	80	13	37142655
Pubmed	Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.	ATP1A1 ATP1A3	3.13e-05	4	80	2	21731499
Pubmed	The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.	ATP1A1 ATP1A3	3.13e-05	4	80	2	12458206
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR1 TLR6	3.13e-05	4	80	2	18547625
Pubmed	TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.	TLR1 TLR6	3.13e-05	4	80	2	22198949
Pubmed	Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway.	PTPN5 PTPRA	3.13e-05	4	80	2	25951993
Pubmed	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	TLR1 TLR6	3.13e-05	4	80	2	20478617
Pubmed	Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.	PTPRA APC	3.13e-05	4	80	2	22354965
Pubmed	Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.	TLR1 TLR6	3.13e-05	4	80	2	11739528
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A1 ATP1A3	3.13e-05	4	80	2	21849490
Pubmed	Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.	ATP1A1 ATP1A3	3.13e-05	4	80	2	17446412
Pubmed	Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.	TLR1 TLR6	3.13e-05	4	80	2	16622218
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR1 TLR6	3.13e-05	4	80	2	25253287
Pubmed	Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.	TLR1 TLR6	3.13e-05	4	80	2	23255565
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR1 TLR6	3.13e-05	4	80	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR1 TLR6	3.13e-05	4	80	2	20348427
Pubmed	Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.	DNAJA3 APC	3.13e-05	4	80	2	17588722
Pubmed	Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1.	ATP1A1 ATP1A3	3.13e-05	4	80	2	19751721
Cytoband	2p13.3	GMCL1 GKN1 APLF	3.49e-05	36	80	3	2p13.3
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A1 ATP1A3	2.40e-04	7	62	2	1208
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR6	5.12e-04	10	62	2	948
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SH3BP1 ARHGAP29 ARHGAP33	6.71e-04	50	62	3	721
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZFHX2 ZEB2	1.18e-03	15	62	2	529
GeneFamily	DNA polymerases	POLE3 POLQ	2.79e-03	23	62	2	535
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF23 ZNF660 ZNF608 ZFHX2 ZNF740 ZNF721 ZNF112 ZEB2	3.02e-03	718	62	8	28
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	STK33 ATP2C2 KCTD4 CP TF DNAH9	1.64e-06	200	80	6	cf191104484bfb2b9f87de416b9453135f8833c1
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	ADAMTS12 KIAA0408 POSTN GALNT17 PDE5A ZEB2	1.64e-06	200	80	6	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	LPS_IL1RA-Epithelial_airway\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	STK33 ATP2C2 KCTD4 CP TF DNAH9	1.64e-06	200	80	6	a5ae33dd4dc1ff6e1a1eec22c4d523d5ab657607
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CP GRIN2A ZEB2 PDLIM5	1.39e-05	170	80	5	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CP GRIN2A ZEB2 PDLIM5	1.39e-05	170	80	5	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 KIAA0408 POSTN GALNT17 PDE5A	1.78e-05	179	80	5	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A EXPH5 ATP2C2 ARHGAP29 GRIN2A	1.88e-05	181	80	5	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO9A EXPH5 ATP2C2 ARHGAP29 GRIN2A	1.93e-05	182	80	5	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 KIAA0408 POSTN GALNT17 PDE5A	1.98e-05	183	80	5	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 KIAA0408 POSTN GALNT17 PDE5A	2.09e-05	185	80	5	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS12 KIAA0408 POSTN GALNT17 PDE5A	2.09e-05	185	80	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	POSTN SLC25A33 PDE5A ZEB2 GPR179	2.09e-05	185	80	5	b1e84228c95be8ccf7c3c1afb66b71ffb93cf61e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 POSTN DEPDC1 POLQ KIF24	2.20e-05	187	80	5	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 POSTN DEPDC1 POLQ KIF24	2.20e-05	187	80	5	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	ASK454-Epithelial-Type_1\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	KIAA0408 EXPH5 AGER ZNF112 ATP1A1	2.25e-05	188	80	5	13f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCell	Control-Epithelial_cells\|Control / group, cell type (main and fine annotations)	NBEAL1 EXPH5 STK33 ATP2C2 PLCH1	2.25e-05	188	80	5	707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 POSTN PDE5A ZEB2 PDLIM5	2.37e-05	190	80	5	70c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 POSTN PDE5A ZEB2 PDLIM5	2.43e-05	191	80	5	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ZNF608 ATP2C2 NR3C2 ATP1A1 PLCH1	2.43e-05	191	80	5	ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCell	Children_(3_yrs)-Epithelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF608 EXPH5 STK33 ATP2C2 PLCH1	2.43e-05	191	80	5	e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 POSTN PDE5A ZEB2 PDLIM5	2.43e-05	191	80	5	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	Epithelial\|World / Lineage, Cell type, age group and donor	EXPH5 STK33 ATP2C2 NR3C2 PLCH1	2.49e-05	192	80	5	499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA0408 PTPN5 CP PCOLCE2 ZEB2	2.68e-05	195	80	5	1c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCell	PND10-Mesenchymal-Mesenchymal_structural\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA0408 PTPN5 CP PCOLCE2 ZEB2	2.68e-05	195	80	5	11d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 PDE5A GRIN2A ZEB2 PDLIM5	2.68e-05	195	80	5	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MYO9A EXPH5 STK33 ATP2C2 PLCH1	2.68e-05	195	80	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA0408 PTPN5 CP PCOLCE2 ZEB2	2.68e-05	195	80	5	1f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIAA0408 PTPN5 CP PCOLCE2 ZEB2	2.68e-05	195	80	5	10f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR1 CCR6 SLAMF7 CLNK POLQ	2.75e-05	196	80	5	53d1f9e9f009d1417a19ca6f9a83ecdf7776ef88
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CP GRIN2A ZEB2 PDLIM5	2.75e-05	196	80	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	PND10-Mesenchymal\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POSTN CP PDE5A PCOLCE2 ZEB2	2.75e-05	196	80	5	ace167a40adb7022b365be3c2b1cbd4ba963739a
ToppCell	PND07-Mesenchymal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POSTN CP PDE5A PCOLCE2 ZEB2	2.75e-05	196	80	5	0050c7134473fbfd7b9f0ae8d6d337713e60b57d
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CSDE1 PTPRA ATP1A1 ARCN1 AZIN1	2.82e-05	197	80	5	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	PND03-Mesenchymal\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POSTN CP PDE5A PCOLCE2 ZEB2	2.82e-05	197	80	5	e3053ef8f604b6892c21c03e12612b49d3d30f23
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CP ATP1A1 CLNK TF SLC39A7	2.82e-05	197	80	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSDE1 PTPRA ATP1A1 ARCN1 AZIN1	2.82e-05	197	80	5	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	MYO9A EXPH5 AGER CP ATP1A1	2.82e-05	197	80	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	PND14-Mesenchymal\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POSTN CP PDE5A PCOLCE2 ZEB2	2.82e-05	197	80	5	9a14bc2e7d6081e2ab0e2e5555fc8804f13d3dbe
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CP ATP1A1 CLNK TF SLC39A7	2.82e-05	197	80	5	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	facs-Heart-RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSDE1 POSTN CP PCOLCE2 ZEB2	2.82e-05	197	80	5	940cf1e54d7c820e04946258a8b784f35c6a144c
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 DUOX2 CP TF ERVFRD-1	2.89e-05	198	80	5	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 DUOX2 CP TF ERVFRD-1	2.89e-05	198	80	5	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	AGER CP ATP1A1 CLNK TF	2.89e-05	198	80	5	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	E18.5-Mesenchymal\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POSTN CP PDE5A PCOLCE2 ZEB2	2.89e-05	198	80	5	a16aa41eab2e297e56de43c22c355df0f79315da
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 DUOX2 CP TF ERVFRD-1	2.96e-05	199	80	5	165ac94b2d56072ad43358b5127d77555221e2d8
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO9A EXPH5 STK33 ATP2C2 PLCH1	2.96e-05	199	80	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Airway-Club\|Control_saline / Treatment groups by lineage, cell group, cell type	KCTD4 CP SLAMF7 TF ERVFRD-1	2.96e-05	199	80	5	5cc8b553a58669a30eb10845beb23983dcdf5a6a
ToppCell	control-unassigned\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SEMA6B ZNF660 AGER DSN1 ARHGAP33	2.96e-05	199	80	5	50e2da35edff1aadef939cfbd4549f73c1a07717
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADAMTS12 KIAA0408 POSTN PDE5A ZEB2	2.96e-05	199	80	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	control-unassigned\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SEMA6B ZNF660 AGER DSN1 ARHGAP33	2.96e-05	199	80	5	5db7c8089172ac8e796613b3cef618d87007a0ab
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CSDE1 PTPRA APC ATP1A1 ZEB2	3.03e-05	200	80	5	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ATP2C2 DUOX2 CP TF DNAH9	3.03e-05	200	80	5	da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	MYO9A NBEAL1 EXPH5 AGER CP	3.03e-05	200	80	5	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SEMA6B POSTN ATP1A1 PDLIM5 SH3BP5	3.03e-05	200	80	5	50b8788494b744e0f0ec8c4d67a1c90ae09dca65
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SEMA6B POSTN ATP1A1 PDLIM5 SH3BP5	3.03e-05	200	80	5	f5f24273bee3259a4a3be99ba53b88defa1286c0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Glia_progenitor_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	ADAMTS12 POSTN PCOLCE2 GRIN2A TF	3.03e-05	200	80	5	6c1b7b0f3cd35d8cfee181ea83c73127dbc41ac5
ToppCell	LPS_IL1RA_TNF-Epithelial_airway\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ATP2C2 DUOX2 CP TF DNAH9	3.03e-05	200	80	5	72c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCell	severe-unassigned\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	POLQ TF DSN1 ARHGAP33	8.36e-05	128	80	4	bef9cf0078fa8498d63f0723f1fa4a3c92405e10
ToppCell	LPS-antiTNF-Unknown\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POSTN DEPDC1 POLQ ARHGAP33	8.62e-05	129	80	4	739b263296c28554967362060b154f7a95e1341d
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	POSTN DEPDC1 POLQ ARHGAP33	8.88e-05	130	80	4	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT17 PCARE CLNK GPR179	9.42e-05	132	80	4	7d6cd16ca1d83d9a618ef5b7fb300c1509eeb129
ToppCell	LPS_only-Myeloid-Dendritic_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TLR1 PCOLCE2 SLAMF7 CLNK	1.46e-04	148	80	4	cb9365663f9cba35d47b5dd9079f42e88b70d915
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 GRIN2A ZEB2 SH3BP5	1.54e-04	150	80	4	1270f33f9d7e46e55adf1a96e8beee858b95589d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 GRIN2A ZEB2 SH3BP5	1.54e-04	150	80	4	156118ce1d69522624196410cba18b8354cd0bb4
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF740 DEPDC1 PLCH1 ARHGAP33	1.66e-04	153	80	4	c4dcdcaa672929c1da870e9fb8ada1bb030ad12f
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor\|E16.5-samps / Age Group, Lineage, Cell class and subclass	EXPH5 KRT74 AGER GPR179	1.71e-04	154	80	4	8a643d91896af9b630a715fb284c1523d01ad1a3
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK33 ATP2C2 DUOX2 DNAH9	1.75e-04	155	80	4	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STK33 ATP2C2 DUOX2 DNAH9	1.75e-04	155	80	4	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	Control-Epithelial_airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP2C2 KCTD4 CP TF	1.88e-04	158	80	4	35aee1c3b92169e73569331022833cb44ab7e7e8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 U2AF2 ZEB2 SH3BP5	1.93e-04	159	80	4	330ecbba97d47bc818a5e8d1d84b05d056bd831e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 U2AF2 ZEB2 SH3BP5	1.93e-04	159	80	4	cbb331eb689d8cea9e1146ba85e0a05d23301c47
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 KIAA0408 CP ZNF112	1.93e-04	159	80	4	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALNT17 STK33 WRN ARHGAP33	1.93e-04	159	80	4	2233fee5dcdb6c7dee5b1bd8efbc07d86b339927
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGB1 DEPDC1 KIF24 DSN1	2.02e-04	161	80	4	0dd1401b4c990d49fccb702a9f9867590a58e203
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGB1 DEPDC1 KIF24 DSN1	2.02e-04	161	80	4	b6a31c033edc74f23a20aab1f18e80cc83ffee4c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF23 GALNT17 SH3BP1 CLNK	2.02e-04	161	80	4	176a4a72bb4892932da3c834d1fea5e211847f92
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGB1 DEPDC1 KIF24 DSN1	2.02e-04	161	80	4	efb811dda4d73107983a5f68302bdcf4f408d5b4
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PCDHGB1 DEPDC1 KIF24 DSN1	2.02e-04	161	80	4	28d5dbd20c9f8e0069f172d552997a044790e1a7
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	STPG1 PCOLCE2 NR3C2 ATP1A3	2.12e-04	163	80	4	0ab043b68e8739adcedda01165a3758cd0d22728
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ATP2C2 DUOX2 TF DNAH9	2.17e-04	164	80	4	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CP PCOLCE2 ATP1A3 ZEB2	2.17e-04	164	80	4	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR1 SH3BP1 SLAMF7 CLNK	2.27e-04	166	80	4	d80c2522cf314d56730d60f160b1247933443378
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR1 SH3BP1 SLAMF7 CLNK	2.27e-04	166	80	4	f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SH3BP1 ZFHX2 ATP1A3 SLAMF7	2.27e-04	166	80	4	de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ATP2C2 FSCN2 CP TF	2.32e-04	167	80	4	31633899aae852873a4887e72c621474b0a51a33
ToppCell	Control-Epithelial_airway-Club_cells-Airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCTD4 CP SLAMF7 TF	2.38e-04	168	80	4	ce87981f4da2779de952c2e5d2bbcdabb265e705
ToppCell	Control\|World / group, cell type (main and fine annotations)	EXPH5 ATP2C2 NR3C2 PLCH1	2.38e-04	168	80	4	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 GRIN2A ZEB2 SH3BP5	2.38e-04	168	80	4	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	Control-Epithelial_airway-Club_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCTD4 CP SLAMF7 TF	2.38e-04	168	80	4	e85bc5398eb36b2b0773a8a7082e3ba740452165
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 ZNF23 GALNT17 EXPH5	2.43e-04	169	80	4	1d5ce2c97f7ef7bdc9f861938077a9aa31d84db6
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	KCTD4 ARHGAP29 SLAMF7 ZEB2	2.43e-04	169	80	4	e7470a5b060881b2a8ce2ab04b0788396aa13889
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	ADAMTS12 ZNF23 GALNT17 EXPH5	2.43e-04	169	80	4	58098f8801ca941aeddafb47e88ab0df8b9edb57
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 ZNF112 POLQ KIF24	2.49e-04	170	80	4	21bfe070e63722672176052b386167ea4c3dc4e5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SCGB1D2 BAZ2A GRIN2A KIF24	2.54e-04	171	80	4	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA0408 POSTN GRIN2A ZEB2	2.60e-04	172	80	4	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KIAA0408 POSTN GRIN2A ZEB2	2.60e-04	172	80	4	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	droplet-Fat-Gat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STPG1 STK33 PLCH1 DNAH9	2.66e-04	173	80	4	f3f67531f72d6d52e19c7f1f2db1ab4026fb70da
ToppCell	droplet-Fat-Gat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STPG1 STK33 PLCH1 DNAH9	2.66e-04	173	80	4	a40a52d8041d45dc3bef74fe55945ae07aa018d6
ToppCell	droplet-Fat-Gat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STPG1 STK33 PLCH1 DNAH9	2.66e-04	173	80	4	f0b4dd1cf41d6ee6abb0e1968b8b39f4fabebcb5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DEPDC1 POLQ KIF24 ARHGAP33	2.72e-04	174	80	4	dbb4e1a6c3319ce40f81bfd2d1745a88a2cc412e
Disease	aspergillosis (is_implicated_in)	AGER TLR1 TLR6	9.48e-07	8	77	3	DOID:13564 (is_implicated_in)
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A1 ATP1A3	1.40e-04	7	77	2	DOID:0060178 (implicated_via_orthology)
Disease	Iron Overload	CP TF	1.40e-04	7	77	2	C0282193
Disease	epilepsy (is_implicated_in)	CP ATP1A3	2.39e-04	9	77	2	DOID:1826 (is_implicated_in)
Disease	nervous system disease (implicated_via_orthology)	ATP1A1 ATP1A3	4.36e-04	12	77	2	DOID:863 (implicated_via_orthology)
Disease	Schizophrenia	ADAMTS12 PTPN5 PTPRA AGER APC CP GRIN2A TF PDLIM5	4.83e-04	883	77	9	C0036341
Disease	Autistic Disorder	CSDE1 APC CP GRIN2A TF	6.13e-04	261	77	5	C0004352
Disease	impotence (implicated_via_orthology)	AGER PDE5A	6.90e-04	15	77	2	DOID:1875 (implicated_via_orthology)
Disease	Tremor, Rubral	CP ARCN1	7.88e-04	16	77	2	C0750940
Disease	Ataxia, Appendicular	CP ARCN1	7.88e-04	16	77	2	C0750937
Disease	Ataxia, Motor	CP ARCN1	7.88e-04	16	77	2	C0278161
Disease	Abnormal coordination	CP ARCN1	7.88e-04	16	77	2	C0520966
Disease	Ataxia, Truncal	CP ARCN1	7.88e-04	16	77	2	C0427190
Disease	transferrin saturation measurement	DUOX2 TF	7.88e-04	16	77	2	EFO_0006333
Disease	Ataxia, Sensory	CP ARCN1	7.88e-04	16	77	2	C0240991
Disease	myocardial infarction (biomarker_via_orthology)	POSTN AIMP1 AGER ZEB2	8.28e-04	160	77	4	DOID:5844 (biomarker_via_orthology)
Disease	phosphatidylcholine 40:6 measurement	PTPRA DNAH9	8.91e-04	17	77	2	EFO_0010389
Disease	Vitiligo	CCR6 CLNK	8.91e-04	17	77	2	C0042900
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR6	8.91e-04	17	77	2	DOID:8677 (biomarker_via_orthology)
Disease	age of onset of asthma	PTPRA TLR1 TLR6	1.17e-03	79	77	3	OBA_2001001
Disease	chronic kidney disease (is_marker_for)	POSTN AGER	1.24e-03	20	77	2	DOID:784 (is_marker_for)
Disease	periodontitis (biomarker_via_orthology)	POSTN AGER	1.37e-03	21	77	2	DOID:824 (biomarker_via_orthology)
Disease	Drug toxicity	TLR1 CP TF	1.40e-03	84	77	3	C0013221
Disease	Adverse reaction to drug	TLR1 CP TF	1.40e-03	84	77	3	C0041755
Disease	Anhedonia	CCR6 ATP1A3	1.79e-03	24	77	2	C0178417
Disease	Ataxia	CP ARCN1	1.94e-03	25	77	2	C0004134
Disease	tuberculosis (is_implicated_in)	TLR1 TLR6	2.43e-03	28	77	2	DOID:399 (is_implicated_in)
Disease	bipolar disorder (is_implicated_in)	GRIN2A ATP1A3	2.61e-03	29	77	2	DOID:3312 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FKQCGVVKMNKRTGQ	EWSR1	381	Q01844
LQGSEGNKVKRTSCM	APLF	366	Q8IW19
MKVGICRNEGSQAKP	CXorf49;	216	A8MYA2
MKQLSLQCSKGRDGI	SH3BP5	431	O60239
GNMKFGTTLKNCRHL	AZIN1	166	O14977
KMRQKVQRGECQTTI	BAZ2A	716	Q9UIF9
KGKGVCRAQTMSNSG	AIMP1	296	Q12904
KRLQACLQGQSGADM	SH3BP1	51	Q9Y3L3
CLQGQSGADMDKRVK	SH3BP1	56	Q9Y3L3
LGKMNRSCQSEKLIG	CCR6	281	P51684
IVGMANKGDCLQKGE	CSDE1	636	O75534
QLQKLKGRCMTVFGD	DNHD1	3426	Q96M86
IQIGRKELNMGQRCS	ACADM	231	P11310
GRNIGLCNGKLQAMS	ATP2C2	611	O75185
GDGSSCQTVRKMFKQ	ADAMTS12	696	P58397
GMKQVQCTGSNERAK	CLDN17	101	P56750
NKEELEGNSMRCGRK	GMCL1	386	Q96IK5
IGRGNLQVCAMASAK	NBEAL1	1581	Q6ZS30
IFRCQAMNRNGKETK	AGER	96	Q15109
QRVCSGEGKQKTDLM	PCDHA9	756	Q9Y5H5
KTTCQLRQDRGGMIQ	PTPN5	526	P54829
TGGMKQKYTVNQCRR	CP	706	P00450
QKCLQAGMNLGARKS	NR3C2	661	P08235
GEDVSKGMAKLCQQQ	GPR179	1856	Q6PRD1
ICKTRRNSVFQQGMK	ATP1A1	936	P05023
GMTKNVEKACQLVNR	DUOX2	1521	Q9NRD8
KVRDKDSGQNGMVTC	PCDHGB1	366	Q9Y5G3
GVCQLVNKMEENTGK	PDE5A	466	O76074
QISNPGFQERCAKKM	DEPDC1	366	Q5TB30
APLCSEKNRMGNKTV	KIF24	666	Q5T7B8
QGKNCKSTLMTLNVG	KCTD4	26	Q8WVF5
KREQSLVSGGNQMCK	KIAA0408	106	Q6ZU52
LVSGGNQMCKEQKAT	KIAA0408	111	Q6ZU52
CANNFAMKGKRKTLN	POLE3	51	Q9NRF9
GDIGTNCQKMTNKTL	EXPH5	1486	Q8NEV8
AQNKIKGCTGSLNMT	PDLIM5	66	Q96HC4
QAGKNMSARLTVVCK	PCOLCE2	351	Q9UKZ9
RGCQNSYMANGEKKL	MSL2	496	Q9HCI7
ACQQEMCSKLRGAQG	ARHGAP33	851	O14559
GRNMGNVNLDKFCKN	ARHGAP29	1036	Q52LW3
LSKFGKNIANMCRGI	GKN1	131	Q9NS71
NREMKNQGSKKTLGS	POLQ	2146	O75417
KKGFSVNPRCQAQME	POLQ	2286	O75417
QCFQKVSVQLGKRSM	DSN1	311	Q9H410
QNGAIMNKGTGRCLE	GALNT17	556	Q6IS24
ICKTRRNSVFQQGMK	ATP1A3	926	P13637
GQLSKGDRQKIMTIC	DNAH9	1766	Q9NYC9
VCRGAGQAKQKKRVM	DNAJA3	291	Q96EY1
KITLTCGRDGGLQNM	ARCN1	281	P48444
NGETALMKACKRGNS	MPHOSPH8	666	Q99549
RKFCIQQVGDMTNRK	PTPRA	381	P18433
RNQTTAKGLCQLMGD	PCARE	66	A6NGG8
KASNGRYVCMKKNGQ	FSCN2	346	O14926
KKQSRSEAMLQATCG	STK33	271	Q9BYT3
QVQKASLGIMGTEKC	WRN	921	Q14191
GVKRCTDQMSLQKRS	SCGB1D2	61	O95969
KVRGSKQMNTLQCAR	SLC25A33	161	Q9BSK2
QSCQKMRSIKAGDNP	TLR1	511	Q15399
GKVRSNSEISGQMKQ	APC	2201	P25054
MNRQGNRKTTKEGSN	CLNK	1	Q7Z7G1
SDINVCRMKGKQEGE	SEMA6B	111	Q9H3T3
FQMNQLRGKKSCHTG	TF	126	P02787
ARQKARKNACEGGSM	ZFHX2	1646	Q9C0A1
CVMAKRKNGTNVGTL	ERVFRD-1	126	P60508
VQSGCSKKQAMRLQL	SLC39A7	371	Q92504
KQRNNVCTRAGFMSK	STPG1	161	Q5TH74
GHDNLQLRKGCKSMN	ZNF721	31	Q8TF20
GKTCGSNTKIMDHQR	ZNF660	196	Q6AZW8
PKVTMGLQSNKNGTC	SLAMF7	131	Q9NQ25
NRKGEKNGMGLCRLS	TFDP3	101	Q5H9I0
MQLNRAKFKANGNCG	PLCH1	691	Q4KWH8
QSCQKMRSIKAGDNP	TLR6	516	Q9Y2C9
HERGRGNSKMKACNN	nan	91	Q8IYB0
KARKSIAQSGVNMCN	ZNF644	686	Q9H582
DGCSGRKNQQKMESI	ZNF112	76	Q9UJU3
DCQKAMQGLTGRKFA	U2AF2	441	P26368
EQKMAQTGRGDCERK	ZNF608	1116	Q9ULD9
NECGKAFSVNGKLMR	ZNF23	451	P17027
QMLTQGAGNRKFKCT	ZEB2	271	O60315
SCMEKGSKQGRNGAI	POSTN	471	Q15063
KRMCQGCQSKTSDGQ	ZNF740	176	Q8NDX6
RKIRGNCDSSGMNLN	ZNF487	161	B1APH4
MSRQLNIKSSGDKGN	KRT74	1	Q7RTS7
SKTDRMGTQLNVACK	MYO9A	1621	B2RTY4
CRKFVKINNSTNEGM	GRIN2A	436	Q12879