Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX1 TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 MAZ SKOR2 POU3F3 POU4F1 TUG1 EN2 NEUROG2 ZNF865	3.27e-05	1271	71	15	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX1 TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 MAZ SKOR2 POU3F3 POU4F1 EN2 NEUROG2 ZNF865	1.04e-04	1244	71	14	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX1 TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 MAZ SKOR2 ZBTB10 POU3F3 POU4F1 ZNF579 EN2 NEUROG2	1.08e-04	1412	71	15	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX1 TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 MAZ SKOR2 ZBTB10 POU3F3 POU4F1 EN2 NEUROG2 ZNF865	1.56e-04	1459	71	15	GO:0000977
GeneOntologyMolecularFunction	chromatin binding	PRDM8 ARID1B CBX6 MAZ SKOR2 KMT2A POU4F1 TOP2B SBNO2 RING1	2.72e-04	739	71	10	GO:0003682
GeneOntologyBiologicalProcess	central nervous system neuron differentiation	SOX1 SPTBN4 PRDM8 BCL11B SKOR2 POU4F1 NEUROG2	9.73e-06	217	71	7	GO:0021953
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX1 TBX18 ZBTB7A FOXD3 PRDM8 FOXL2 MYOZ1 CBX6 MAZ SKOR2 ZBTB10 POU3F3 POU4F1 SBNO2 RING1	6.79e-05	1399	71	15	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX1 TBX18 ZBTB7A FOXD3 PRDM8 FOXL2 MYOZ1 CBX6 MAZ SKOR2 ZBTB10 POU3F3 POU4F1 SBNO2 RING1	7.60e-05	1413	71	15	GO:1902679
GeneOntologyBiologicalProcess	neuron development	SOX1 SPTBN4 NKX2-8 PRDM8 ARID1B BCL11B SKOR2 POU4F1 TUG1 RAB21 EN2 NEUROG2 MTCH1 TOP2B ADCYAP1	1.12e-04	1463	71	15	GO:0048666
Domain	BTB	ZBTB7A KCTD13 KCNC3 KBTBD11 ZBTB10	5.74e-04	180	70	5	SM00225
Domain	BTB/POZ_dom	ZBTB7A KCTD13 KCNC3 KBTBD11 ZBTB10	6.49e-04	185	70	5	IPR000210
Domain	SKP1/BTB/POZ	ZBTB7A KCTD13 KCNC3 KBTBD11 ZBTB10	7.15e-04	189	70	5	IPR011333
Domain	POU	POU3F3 POU4F1	1.61e-03	16	70	2	SM00352
Domain	POU_2	POU3F3 POU4F1	1.61e-03	16	70	2	PS00465
Domain	POU_dom	POU3F3 POU4F1	1.61e-03	16	70	2	IPR000327
Domain	POU_3	POU3F3 POU4F1	1.61e-03	16	70	2	PS51179
Domain	Pou	POU3F3 POU4F1	1.61e-03	16	70	2	PF00157
Domain	POU_1	POU3F3 POU4F1	1.61e-03	16	70	2	PS00035
Domain	POU	POU3F3 POU4F1	1.82e-03	17	70	2	IPR013847
Domain	-	LONP1 TOP2B	2.78e-03	21	70	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	LONP1 TOP2B	3.05e-03	22	70	2	IPR014721
Domain	BTB	ZBTB7A KCTD13 KBTBD11 ZBTB10	3.07e-03	160	70	4	PS50097
Domain	Collagen	COL23A1 C1QL2 COL17A1	4.00e-03	85	70	3	IPR008160
Domain	Collagen	COL23A1 C1QL2 COL17A1	4.00e-03	85	70	3	PF01391
Domain	-	POU3F3 POU4F1	4.57e-03	27	70	2	1.10.260.40
Domain	Homeobox_CS	NKX2-8 POU3F3 POU4F1 EN2	5.24e-03	186	70	4	IPR017970
Domain	Lambda_DNA-bd_dom	POU3F3 POU4F1	5.27e-03	29	70	2	IPR010982
Domain	Ribosomal_S5_D2-typ_fold	LONP1 TOP2B	7.19e-03	34	70	2	IPR020568
Domain	Ion_trans_dom	KCNC3 CACNA1I RYR3	9.01e-03	114	70	3	IPR005821
Domain	Ion_trans	KCNC3 CACNA1I RYR3	9.01e-03	114	70	3	PF00520
Domain	PH	SPTBN4 TBC1D2B IRS1 EXOC8	1.07e-02	229	70	4	PF00169
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX1 TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 MAZ SKOR2 KMT2A POU3F3 POU4F1 EN2 NEUROG2	9.48e-09	908	76	14	19274049
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	TBX18 ZBTB7A FOXD3 NKX2-8 BCL11B FOXL2 SKOR2 POU4F1 EN2 NEUROG2	3.06e-07	544	76	10	28473536
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	FZD8 BCL11B POU3F3	4.48e-06	15	76	3	18255031
Pubmed	Retinoic acid influences the development of the inferior olivary nucleus in the rodent.	POU4F1 PCDH10	4.71e-06	2	76	2	15882583
Pubmed	Intermediate Progenitor Cohorts Differentially Generate Cortical Layers and Require Tbr2 for Timely Acquisition of Neuronal Subtype Identity.	BCL11B NEUROG2 ADCYAP1	7.99e-06	18	76	3	27320921
Pubmed	m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs.	ARID1B BCL11B POU4F1	9.47e-06	19	76	3	36039295
Pubmed	Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord.	FOXD3 POU4F1 NEUROG2	1.30e-05	21	76	3	15930101
Pubmed	Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord.	FOXD3 POU4F1 EN2	1.30e-05	21	76	3	12062038
Pubmed	DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.	SOX1 BCL11B POU3F3	1.72e-05	23	76	3	30329130
Pubmed	Multiple knockout mouse models reveal lincRNAs are required for life and brain development.	BCL11B POU3F3 TUG1	1.96e-05	24	76	3	24381249
Pubmed	Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.	BCL11B POU3F3 NEUROG2	2.23e-05	25	76	3	39271675
Pubmed	Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord.	SOX1 FOXD3 PRDM8	2.51e-05	26	76	3	28082864
Pubmed	Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation.	EN2 NEUROG2	2.82e-05	4	76	2	18974090
Pubmed	Defining developmental diversification of diencephalon neurons through single cell gene expression profiling.	C1QL2 POU4F1 NEUROG2	4.31e-05	31	76	3	30872278
Pubmed	Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development.	POU4F1 NEUROG2	4.69e-05	5	76	2	18308300
Pubmed	Spatial rearrangement of Purkinje cell subsets forms the transverse and longitudinal compartmentalization in the mouse embryonic cerebellum.	SKOR2 PCDH10	4.69e-05	5	76	2	28542916
Pubmed	IRS pleckstrin homology domains bind to acidic motifs in proteins.	LONP1 IRS1	4.69e-05	5	76	2	9813005
Pubmed	A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.	FOXD3 POU4F1 NEUROG2	6.24e-05	35	76	3	26988119
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F3 POU4F1	7.03e-05	6	76	2	2739723
Pubmed	ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.	ARID1B BCL11B	7.03e-05	6	76	2	38816354
Pubmed	Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.	PNMA6F PNMA6E	7.03e-05	6	76	2	27250503
Pubmed	USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.	CBX6 RING1	7.03e-05	6	76	2	28839133
Pubmed	Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.	POU4F1 NEUROG2	7.03e-05	6	76	2	19641016
Pubmed	The dynamics of native Atoh7 protein expression during mouse retinal histogenesis, revealed with a new antibody.	POU4F1 NEUROG2	7.03e-05	6	76	2	29225067
Pubmed	Common Origin of the Cerebellar Dual Somatotopic Areas Revealed by Tracking Embryonic Purkinje Cell Clusters with Birthdate Tagging.	SKOR2 PCDH10	7.03e-05	6	76	2	33055198
Pubmed	MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis.	KMT2A EN2	9.83e-05	7	76	2	9724755
Pubmed	Dual functions of Dab1 during brain development.	BCL11B POU3F3	9.83e-05	7	76	2	18981215
Pubmed	Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum.	BCL11B NEUROG2	9.83e-05	7	76	2	21864333
Pubmed	POU-III transcription factors (Brn1, Brn2, and Oct6) influence neurogenesis, molecular identity, and migratory destination of upper-layer cells of the cerebral cortex.	BCL11B POU3F3	1.31e-04	8	76	2	22892427
Pubmed	Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin.	BCL11B POU3F3	1.31e-04	8	76	2	28213441
Pubmed	The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells.	EN2 NEUROG2	1.31e-04	8	76	2	20873986
Pubmed	Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors.	BCL11B NEUROG2	1.31e-04	8	76	2	22935140
Pubmed	Distribution of protocadherin 9 protein in the developing mouse nervous system.	POU4F1 PCDH10	1.68e-04	9	76	2	22982106
Pubmed	Long noncoding RNA uc.338 promotes cell proliferation through association with BMI1 in hepatocellular carcinoma.	TUG1 RING1	1.68e-04	9	76	2	27154519
Pubmed	Dual recombinase fate mapping reveals a transient cholinergic phenotype in multiple populations of developing glutamatergic neurons.	BCL11B POU4F1	1.68e-04	9	76	2	31396962
Pubmed	Chromosomal organization of mammalian POU domain factors.	POU3F3 POU4F1	1.68e-04	9	76	2	8276396
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F3 EN2	1.68e-04	9	76	2	15872005
Pubmed	Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly.	PRDM8 BCL11B	1.68e-04	9	76	2	22284184
Pubmed	Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome.	BCL11B TOP2B	1.68e-04	9	76	2	31541646
Pubmed	WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.	FZD8 FOXL2 POU4F1	1.83e-04	50	76	3	18351662
Pubmed	Molecular architecture of the developing mouse brain.	FZD8 TBX18 NKX2-8 EN2	2.06e-04	132	76	4	34321664
Pubmed	Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons.	POU4F1 NEUROG2	2.10e-04	10	76	2	15901662
Pubmed	Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.	BCL11B POU3F3	2.10e-04	10	76	2	32161359
Pubmed	Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.	ARID1B KMT2A	2.10e-04	10	76	2	12665591
Pubmed	Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain.	BCL11B NEUROG2	2.10e-04	10	76	2	24124161
Pubmed	Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons.	POU4F1 NEUROG2	2.10e-04	10	76	2	11502254
Pubmed	The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.	POU4F1 NEUROG2	2.10e-04	10	76	2	15872002
Pubmed	Emergence of the sensory nervous system as defined by Foxs1 expression.	POU4F1 NEUROG2	2.10e-04	10	76	2	17309606
Pubmed	Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.	FOXL2 POU4F1	2.10e-04	10	76	2	38714644
Pubmed	KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.	BCL11B KCTD13	2.10e-04	10	76	2	38489388
Pubmed	TSHZ3 and SOX9 regulate the timing of smooth muscle cell differentiation in the ureter by reducing myocardin activity.	TBX18 MYLK	2.10e-04	10	76	2	23671695
Pubmed	Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.	BCL11B PCDH10	2.10e-04	10	76	2	34145365
Pubmed	Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord.	FOXD3 POU4F1	2.56e-04	11	76	2	31787878
Pubmed	Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia.	FOXD3 NEUROG2	2.56e-04	11	76	2	10398684
Pubmed	scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse.	BCL11B POU3F3	2.56e-04	11	76	2	34184026
Pubmed	Expression of the mouse PR domain protein Prdm8 in the developing central nervous system.	PRDM8 BCL11B	2.56e-04	11	76	2	19616129
Pubmed	Temporal control of neural crest lineage generation by Wnt/β-catenin signaling.	POU4F1 NEUROG2	2.56e-04	11	76	2	22573620
Pubmed	MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2.	KMT2A RING1	2.56e-04	11	76	2	31856871
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ARID1B MAZ POU3F3 IRS1 INTS3 RAB21 MTCH1 TMUB2 TOP2B EXOC8	2.84e-04	1203	76	10	29180619
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	ZBTB7A BCL11B MAZ ZBTB10 INTS3 ZNF865 RING1	2.89e-04	583	76	7	29844126
Pubmed	Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.	FOXD3 POU4F1	3.07e-04	12	76	2	28625870
Pubmed	Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.	POU4F1 NEUROG2	3.07e-04	12	76	2	21771810
Pubmed	Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex.	BCL11B POU4F1	3.62e-04	13	76	2	30858607
Pubmed	Characterization of Olig2 expression during cerebellar development.	SKOR2 NEUROG2	3.62e-04	13	76	2	24594479
Pubmed	The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway.	BCL11B POU3F3	3.62e-04	13	76	2	25698753
Pubmed	Progenitor cell diversity in the developing mouse neocortex.	BCL11B POU3F3	3.62e-04	13	76	2	33649223
Pubmed	Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon.	EN2 NEUROG2	3.62e-04	13	76	2	16438966
Pubmed	A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors.	BCL11B NEUROG2	3.62e-04	13	76	2	35915089
Pubmed	Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.	POU4F1 NEUROG2	3.62e-04	13	76	2	16396906
Pubmed	Kctd13 deletion reduces synaptic transmission via increased RhoA.	BCL11B KCTD13	3.62e-04	13	76	2	29088697
Pubmed	Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation.	BCL11B POU3F3	3.62e-04	13	76	2	21485009
Pubmed	Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain.	SOX1 BCL11B	3.62e-04	13	76	2	24927931
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB7A BCL11B ZBTB10	3.62e-04	63	76	3	34351428
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	LONP1 ARID1B MAP3K15 FAM181B NEUROG2 RING1	3.68e-04	431	76	6	33660365
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	ARID1B BCL11B NEUROG2	3.97e-04	65	76	3	26655900
Pubmed	Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.	BCL11B NEUROG2	4.22e-04	14	76	2	26138486
Pubmed	Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development.	POU4F1 NEUROG2	4.22e-04	14	76	2	31371375
Pubmed	Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.	POU4F1 NEUROG2	4.22e-04	14	76	2	15733660
Pubmed	Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.	ARID1B TOP2B	4.22e-04	14	76	2	36289231
Pubmed	Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.	POU4F1 NEUROG2	4.22e-04	14	76	2	17159989
Pubmed	Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors.	BCL11B POU3F3	4.22e-04	14	76	2	20460369
Pubmed	MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression.	BCL11B NEUROG2	4.22e-04	14	76	2	28232627
Pubmed	The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.	BCL11B NEUROG2	4.22e-04	14	76	2	25757017
Pubmed	Formation and function of the meningeal arachnoid barrier around the developing mouse brain.	TBX18 BCL11B	4.22e-04	14	76	2	36996816
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F3 NEUROG2	4.22e-04	14	76	2	17141158
Pubmed	PRC1 preserves epidermal tissue integrity independently of PRC2.	COL17A1 RING1	4.22e-04	14	76	2	30567998
Pubmed	Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina.	POU4F1 NEUROG2	4.22e-04	14	76	2	25100656
Pubmed	Orchestration of Neuronal Differentiation and Progenitor Pool Expansion in the Developing Cortex by SoxC Genes.	BCL11B NEUROG2	4.86e-04	15	76	2	26203155
Pubmed	FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development.	SOX1 BCL11B	4.86e-04	15	76	2	34301831
Pubmed	Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate.	NKX2-8 EN2	4.86e-04	15	76	2	34884468
Pubmed	DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.	BCL11B POU3F3	4.86e-04	15	76	2	25556833
Pubmed	Satb2 Is Required for the Development of a Spinal Exteroceptive Microcircuit that Modulates Limb Position.	BCL11B POU4F1	4.86e-04	15	76	2	27478017
Pubmed	Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex.	POU3F3 NEUROG2	4.86e-04	15	76	2	18940587
Pubmed	An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes.	POU4F1 NEUROG2	4.86e-04	15	76	2	23515312
Pubmed	Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.	POU4F1 NEUROG2	4.86e-04	15	76	2	18507827
Pubmed	Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.	CBX6 RING1	4.86e-04	15	76	2	20601937
Pubmed	Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes.	BCL11B POU3F3	4.86e-04	15	76	2	22723706
Pubmed	Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.	BCL11B POU3F3	4.86e-04	15	76	2	28552558
Pubmed	Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development.	SKOR2 NEUROG2	4.86e-04	15	76	2	22513377
Pubmed	Integral bHLH factor regulation of cell cycle exit and RGC differentiation.	POU4F1 NEUROG2	4.86e-04	15	76	2	29770538
Coexpression	DAWSON_METHYLATED_IN_LYMPHOMA_TCL1	SOX1 TBX18 FOXD3 PCDH10	2.50e-05	59	75	4	M1238
Coexpression	DAWSON_METHYLATED_IN_LYMPHOMA_TCL1	SOX1 TBX18 FOXD3 PCDH10	2.50e-05	59	75	4	MM528
Coexpression	BENPORATH_EED_TARGETS	SOX1 FZD8 ZBTB7A FOXD3 NKX2-8 FOXL2 POU4F1 EN2 NEUROG2 PCDH10 ADCYAP1 RYR3	4.43e-05	1059	75	12	M7617
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SOX1 C1QL2 FOXD3 NKX2-8 PRDM8 KCNC3 POU3F3 POU4F1 ADCYAP1	4.74e-05	591	75	9	M2019
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	SOX1 TBX18 C1QL2 PRDM8 ADRA1D FOXL2 KCNC3 HS3ST6 FAM181B EN2 NEUROG2 HRH3	5.08e-05	1074	75	12	M1941
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	SOX1 C1QL2 FOXD3 NKX2-8 PRDM8 KCNC3 POU3F3 POU4F1 ADCYAP1	5.39e-05	601	75	9	MM866
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL23A1 RNF150 COL17A1 MYLK SKOR2 RYR3	1.07e-06	196	76	6	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QL2 KSR1 RAVER2 ADCYAP1 RYR3	2.61e-06	127	76	5	fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QL2 BCL11B RAVER2 ADCYAP1 RYR3	3.64e-06	136	76	5	1f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C1QL2 BCL11B RAVER2 ADCYAP1 RYR3	4.20e-06	140	76	5	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C1QL2 BCL11B RAVER2 ADCYAP1 RYR3	4.82e-06	144	76	5	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRDM8 ADRA1D TMEM121B CACNA1I ADCYAP1	7.34e-06	157	76	5	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ADRA1D BCL11B TMEM121B RAVER2 RYR3	1.02e-05	168	76	5	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL23A1 KBTBD11 ZNF865 SBNO2 KIF1C	1.14e-05	172	76	5	1bbf5ed7d13635f9a7e528060341e0652699bd7c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXD3 GOLGA6L2 POU3F3 EN2 NEUROG2	1.31e-05	177	76	5	6f3b254e56e722cc23495b49e99a4abce0243cb3
ToppCell	droplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL11B SPNS2 KBTBD11 KMT2A TOP2B	1.35e-05	178	76	5	8aef208b6351143562c87715bb11628880abce94
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX1 FOXD3 GOLGA6L2 POU3F3 FAM181B	1.58e-05	184	76	5	7712f2e1fae5cdde2d4e355b860dc8536b28e4f6
ToppCell	droplet-Skin\|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL23A1 BCL11B COL17A1 HS3ST6 SLC27A3	1.62e-05	185	76	5	657fd191ed160f8620d57b33820ec7222806f289
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL23A1 RNF150 MYLK IRS1 RYR3	1.75e-05	188	76	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	COL23A1 RNF150 MYLK IRS1 RYR3	1.85e-05	190	76	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL23A1 RNF150 COL17A1 MYLK RYR3	2.20e-05	197	76	5	f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell	Skin-Mesangial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	SOX1 C1QL2 ADRA1D MYLK KCNC3	2.30e-05	199	76	5	bcb78838a91cc7828680fb413fbacdb091c5fac0
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	TBX18 ADRA1D MYLK MYOZ1 PCDH10	2.30e-05	199	76	5	2c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 FZD8 C11orf68 RAVER2 FAM181B	2.36e-05	200	76	5	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	SOX1 FZD8 C11orf68 RAVER2 FAM181B	2.36e-05	200	76	5	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Mixed_Serous_and_Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	SOX1 BCL11B PNMA6E SKOR2	4.51e-05	115	76	4	c724e8b1fddcefdaa8d247aaff68c986538068f7
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-mesenchymal_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SPTBN4 VSIG8 MTCH1 SLC27A3	5.50e-05	121	76	4	176de42c088988fe1a7838f96add26ee8a30e543
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7-Slc17a6.Nptxr-Rorb_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PRDM8 ADRA1D COL17A1 ADCYAP1	6.24e-05	125	76	4	be820e4db3da737101f34ea9d2848a3ceb53f417
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPTBN4 FOXL2 MYOZ1 SPNS2	6.44e-05	126	76	4	10e1448a03f79965b72922fd83ef51de1b7b474f
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL11B RAVER2 ADCYAP1 RYR3	6.44e-05	126	76	4	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Nos1_(CA3_Principal_cells)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRDM8 ADRA1D MYOZ1 RAVER2	6.84e-05	128	76	4	9128b633879d21de2ebe651384cfec6d2c3c2932
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 CACNG8 RAVER2 SBNO2	6.84e-05	128	76	4	7e3f5cea91af005f08d8e9340fb8630bf1c887c3
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 CACNG8 RAVER2 SBNO2	6.84e-05	128	76	4	a876303c852db2af9418d1a1711d7c950805018a
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)-\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 CACNG8 RAVER2 SBNO2	6.84e-05	128	76	4	388062f840fd04cb8087f27a9a78e7a192920e3e
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL11B RAVER2 ADCYAP1 RYR3	7.94e-05	133	76	4	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
ToppCell	mild-Myeloid-CD14_Monocytes_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	COL23A1 RNF150 KCNC3 MPEG1	8.17e-05	134	76	4	8ba1f8d0af63bb7a802a002e72fe181b203cb451
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BCL11B RAVER2 ADCYAP1 RYR3	8.17e-05	134	76	4	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
Disease	amnestic disorder (implicated_via_orthology)	IRS1 HRH3	2.21e-04	9	74	2	DOID:10914 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	SKOR2 KIF1C	4.03e-04	12	74	2	DOID:863 (implicated_via_orthology)
Disease	acute myeloid leukemia (implicated_via_orthology)	KMT2A TOP2B	4.03e-04	12	74	2	DOID:9119 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	NKX2-8 ARID1B CBX6 TOP2B RING1	5.75e-04	268	74	5	DOID:162 (implicated_via_orthology)
Disease	response to radiation, Urinary retention	NKX2-8 MEX3D	8.24e-04	17	74	2	GO_0009314, HP_0000016
Disease	ischemia (implicated_via_orthology)	LONP1 ARID1B	8.24e-04	17	74	2	DOID:326 (implicated_via_orthology)
Disease	Myeloid Leukemia	KMT2A TOP2B	9.25e-04	18	74	2	C0023470
Disease	Leukemia, Monocytic, Chronic	KMT2A TOP2B	9.25e-04	18	74	2	C0023466

Protein segments in the cluster

Peptide	Gene	Start	Entry
EATGGAAGAGGAGRG	KCTD13	281	Q8WZ19
GGAGSLGAGGAFGEA	COL17A1	1316	Q9UMD9
IDKGAGGGGAGQGAG	CBX6	181	O95503
GAGAGGAGAGAVAAA	ARID1B	411	Q8NFD5
AAAAAAAAGGGGGGG	ARID1B	426	Q8NFD5
GDNWEEGGGGGGGME	CDV3	121	Q9UKY7
GAGAEAGAEAGAGAG	ARMCX4	1826	Q5H9R4
MAAAAGDGGGEGGAG	RAVER2	1	Q9HCJ3
MAAAGGGGGGAAAAG	RAB21	1	Q9UL25
AAAAASGAAGGGGGG	INTS3	11	Q68E01
HGDGGGLSGGAAAGV	MPEG1	646	Q2M385
AGGAGAAAGGGGAHD	POU4F1	131	Q01851
LCGGGVGADGGGSDR	MYLK	831	Q15746
GAEAGQGARGGVAAG	NEUROG2	56	Q9H2A3
GGAAGAGGAGTGAAN	HECA	61	Q9UBI9
DGAGGGAAGEDGDLG	LRFN1	736	Q9P244
ADAGAAGGEAGGAGA	LMTK3	1256	Q96Q04
RAGGGGDAGKGNAAG	COL23A1	6	Q86Y22
AGEGGGAGEAGGVGE	PNMA6E	121	A0A0J9YXQ4
GAGEAGGVGEVGAAG	PNMA6E	126	A0A0J9YXQ4
GGVGEVGAAGEAGGT	PNMA6E	131	A0A0J9YXQ4
VGAAGEAGGTGEAGA	PNMA6E	136	A0A0J9YXQ4
AAGEAGGAGEAGGVG	PNMA6E	156	A0A0J9YXQ4
GGAGEAGGVGEAGAA	PNMA6E	161	A0A0J9YXQ4
AGGVGEAGAAGEAGG	PNMA6E	166	A0A0J9YXQ4
EAGAAGEAGGAGEAG	PNMA6E	171	A0A0J9YXQ4
GEAGGAGEAGAAGEG	PNMA6E	176	A0A0J9YXQ4
AGEAGAAGEGGAAGE	PNMA6E	181	A0A0J9YXQ4
AAGEGGAAGEAGGAG	PNMA6E	186	A0A0J9YXQ4
GAAGEAGGAGEAGGV	PNMA6E	191	A0A0J9YXQ4
AGGAGEAGGVGEAGA	PNMA6E	196	A0A0J9YXQ4
GEAGAAGEAGGAGEA	PNMA6E	206	A0A0J9YXQ4
AGEAGGAGEAGGVGE	PNMA6E	211	A0A0J9YXQ4
GAGEAGGVGEAGAAG	PNMA6E	216	A0A0J9YXQ4
GGVGEAGAAGEAGGA	PNMA6E	221	A0A0J9YXQ4
AGAAGEAGGAGEAGA	PNMA6E	226	A0A0J9YXQ4
EAGGAGEAGAAGEAG	PNMA6E	231	A0A0J9YXQ4
GEAGAAGEAGGAGEG	PNMA6E	236	A0A0J9YXQ4
GAAGEAGAVGEAGGT	PNMA6E	281	A0A0J9YXQ4
GAGEAGAAGEAGSVG	PNMA6F	116	A0A0J9YX94
GAAGEAGSVGEAGGV	PNMA6F	121	A0A0J9YX94
AGGIGEAGGVGEAGA	PNMA6F	146	A0A0J9YX94
AAGEAGAAGEAGGAG	PNMA6F	166	A0A0J9YX94
GAAGEAGGAGEAGGA	PNMA6F	171	A0A0J9YX94
AGGAGEAGGAGEAGG	PNMA6F	176	A0A0J9YX94
EAGGAGEAGGAGEEG	PNMA6F	181	A0A0J9YX94
GTGEEGGAGEAGGAG	PNMA6F	196	A0A0J9YX94
GGAGEAGGAGEEGGE	PNMA6F	201	A0A0J9YX94
EGGGGGDAAAAEGGA	KSR1	16	Q8IVT5
LFGAGGAAGGCGVAG	FOXL2	166	P58012
GAAGGCGVAGAGADG	FOXL2	171	P58012
GAAGDGAAAAGGADG	MEX3D	81	Q86XN8
TVGEEEGGGAGSGGG	KIF1C	806	O43896
GGGGEAGAGGGAAAV	MAZ	246	P56270
AGAGGGAAAVAAGGV	MAZ	251	P56270
SEGGAEEGAGGAGGS	LONP1	86	P36776
EEGAGGAGGSAGAGE	LONP1	91	P36776
GAGGEDVGAGGEDVG	GOLGA6L2	676	Q8N9W4
GAGGEDVGAGGEDAG	GOLGA6L2	791	Q8N9W4
GEDAGAGGEDAGAGG	GOLGA6L2	801	Q8N9W4
GGEDVGAGGEDVGAG	GOLGA6L2	856	Q8N9W4
AGLGGAGTGGAGGDV	FAM181B	191	A6NEQ2
CGGGGGGEVGTAAAQ	NKX2-8	181	O15522
LTAVDGGGGGGVGEG	PCDH10	201	Q9P2E7
HDGAAALGAGGGGGS	IRS1	121	P35568
AASGGEEGVGGAGGR	EXOC8	116	Q8IYI6
RGVGGSLGGGAGDDA	ADCYAP1	111	P18509
GGAGGAAAGAGAAGA	FZD8	351	Q9H461
GAAVGGGAGATAAGG	FZD8	626	Q9H461
GAVGAFGGAAGGAGG	CACNG8	331	Q8WXS5
GCGDAGAGGAVNGRG	BCL11B	641	Q9C0K0
VVGGGAGVGGDSEGE	C1QL2	131	Q7Z5L3
SDEEGRGGAGGGGAG	CACNA1I	2106	Q9P0X4
RGGAGGGGAGSEHSE	CACNA1I	2111	Q9P0X4
EEGGGGQGDGGSSLA	FBXO28	11	Q9NVF7
AVGAEAGEATLGGGG	HRH3	281	Q9Y5N1
AVFGESGGGGGSGED	KMT2A	131	Q03164
SGGGGGSGEDEQFLG	KMT2A	136	Q03164
RGGGAGGEGGASGAE	EN2	96	P19622
ASGAEGGGGAGGSEQ	EN2	106	P19622
IVHSDAAGAGGGGGG	POU3F3	21	P20264
GGVGGGAGSEDSGDR	RING1	221	Q06587
ADGCKGGVGGEEGGA	FOXD3	101	Q9UJU5
AGGGQGAGAGQGAAL	HS3ST6	11	Q96QI5
GETGAAGVDGGCGGR	LIPE	1061	Q05469
GAGAAGGGGAELHTE	RNF150	56	Q9ULK6
AEGAAGGSGEGESGG	MAP3K15	41	Q6ZN16
GAGAGAGARGGAAAG	MTCH1	21	Q9NZJ7
EAAAAGGGVGAGAGG	RRAGC	36	Q9HB90
GCGAGAGVGGGNGAL	TOP2B	6	Q02880
GGAGGGLGAAAAAGE	TMEM121B	296	Q9BXQ6
GSGSGGGGGHQEAEL	PRDM8	286	Q9NQV8
GAAGGAGGGQGAASD	PRDM8	481	Q9NQV8
GALGEGAGAGGAAGG	SBNO2	1331	Q9Y2G9
GARGAGGAGVSAAGD	SPNS2	41	Q8IVW8
AGGGGAAVAMGVGVG	SOX1	146	O00570
AREGEAGGDAGQGGG	KBTBD11	576	O94819
AGGDAGQGGGFEALG	KBTBD11	581	O94819
GGGGGVVGAGSGEDN	ADRA1D	51	P25100
AAAVAGVGRGGGGAE	C11orf68	6	Q9H3H3
GGGGSSGIGGEDGVH	ZNF865	11	P0CJ78
GVSGGEDAGGAAVAG	ZNF865	766	P0CJ78
EDAGGAAVAGAGGGA	ZNF865	771	P0CJ78
GNGGGVGGGACGDLA	VSIG8	306	P0DPA2
AEFAGGDGAARGGGA	SLC27A3	146	Q5K4L6
DDGGCSRGGGAGEKG	TBX18	51	O95935
TGENGGEGAAQGGGH	RYR3	86	Q15413
GFGAAGEAGVAGAGL	TUG1	101	A0A6I8PU40
GGGGAAGAAGAAGTA	SPTBN4	671	Q9H254
GRGDSTGEAGAGGGV	TMUB2	116	Q71RG4
AAAAGQDGGGGGGAD	PPP1R3F	66	Q6ZSY5
AAVAAGGAGGGGEGS	PPP1R3F	501	Q6ZSY5
GAGGGCVAGVGVGAG	SKOR2	351	Q2VWA4
GVGAGAGAGAGAGAK	SKOR2	361	Q2VWA4
AEALGGAGAGGAGAA	SKOR2	431	Q2VWA4
GGDGGDEVEGSGVGA	ZBTB10	211	Q96DT7
ECGGASEGGEGQNGG	ZNF579	356	Q8NAF0
GGGGGEGAAQGAAAE	TBC1D2B	11	Q9UPU7
LNVAGAGGGGDSGGG	ZBTB7A	556	O95365
GEAAGAAGDGVAAGG	GOLGA8CP	486	A6NN73
DEAGAGGGGLDGAGG	KCNC3	226	Q14003
GVGETGSGDQAGGEG	MYOZ1	161	Q9NP98