Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessendosomal vesicle fusion

VPS18 ANKFY1

1.29e-0416222GO:0034058
GeneOntologyCellularComponentbasement membrane

LAMB2 LAMC3 NTN3

2.39e-04122213GO:0005604
DomainEGF_LAM_1

NTN5 LAMB2 LAMC3 NTN3

3.88e-0830224PS01248
DomainEGF_LAM_2

NTN5 LAMB2 LAMC3 NTN3

3.88e-0830224PS50027
DomainEGF_Lam

NTN5 LAMB2 LAMC3 NTN3

7.38e-0835224SM00180
DomainLaminin_EGF

NTN5 LAMB2 LAMC3 NTN3

7.38e-0835224PF00053
DomainLaminin_EGF

NTN5 LAMB2 LAMC3 NTN3

1.04e-0738224IPR002049
DomainLAMININ_NTER

LAMB2 LAMC3 NTN3

7.86e-0716223PS51117
DomainLaminin_N

LAMB2 LAMC3 NTN3

7.86e-0716223PF00055
DomainLaminin_N

LAMB2 LAMC3 NTN3

7.86e-0716223IPR008211
DomainLamNT

LAMB2 LAMC3 NTN3

7.86e-0716223SM00136
DomainEGF_1

NTN5 LAMB2 LAMC3 NTN3 MASP2

9.93e-06255225PS00022
DomainEGF_2

NTN5 LAMB2 LAMC3 NTN3 MASP2

1.20e-05265225PS01186
DomainGalactose-bd-like

LAMB2 LAMC3 NTN3

1.77e-0494223IPR008979
DomainLCE

LCE4A LCE3C

1.78e-0417222PF14672
DomainLCE

LCE4A LCE3C

1.78e-0417222IPR028205
DomainC345C

NTN5 NTN3

1.78e-0417222SM00643
DomainEGF-like_CS

LAMB2 LAMC3 NTN3 MASP2

2.24e-04261224IPR013032
DomainNTR

NTN5 NTN3

2.24e-0419222PF01759
DomainNetrin_module_non-TIMP

NTN5 NTN3

2.24e-0419222IPR018933
DomainNetrin_domain

NTN5 NTN3

3.30e-0423222IPR001134
DomainNTR

NTN5 NTN3

3.30e-0423222PS50189
DomainTIMP-like_OB-fold

NTN5 NTN3

4.23e-0426222IPR008993
DomainSPRR/LCE

LCE4A LCE3C

4.91e-0428222IPR026075
DomainGrowth_fac_rcpt_

LAMB2 LAMC3 NTN3

7.83e-04156223IPR009030
DomainEGF

LAMB2 LAMC3 MASP2

2.54e-03235223SM00181
DomainEGF-like_dom

LAMB2 LAMC3 MASP2

2.99e-03249223IPR000742
PathwayREACTOME_LAMININ_INTERACTIONS

LAMB2 LAMC3

4.52e-0430152M27216
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMB2 LAMC3

4.52e-0430152M27772
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMB2 LAMC3

8.46e-0441152M27778
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

LAMB2 LAMC3

1.06e-0346152M239
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMB2 LAMC3

1.75e-0359152M27218
PathwayREACTOME_SIGNALING_BY_MET

LAMB2 LAMC3

3.11e-0379152M27643
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMB2 LAMC3

3.50e-0384152M7098
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMB2 LAMC3

3.50e-0384152M3228
Pubmed

Laminin-Dependent Interaction between Astrocytes and Microglia: A Role in Retinal Angiogenesis.

LAMB2 LAMC3

3.82e-07222228697326
Pubmed

Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina.

LAMB2 LAMC3

3.82e-07222223571221
Pubmed

Cellular and axonal constituents of neocortical molecular layer heterotopia.

LAMB2 LAMC3

3.82e-07222225247689
Pubmed

Laminin deficits induce alterations in the development of dopaminergic neurons in the mouse retina.

LAMB2 LAMC3

3.82e-07222217711601
Pubmed

Defective formation of the inner limiting membrane in laminin beta2- and gamma3-null mice produces retinal dysplasia.

LAMB2 LAMC3

3.82e-07222219907020
Pubmed

β2 and γ3 laminins are critical cortical basement membrane components: ablation of Lamb2 and Lamc3 genes disrupts cortical lamination and produces dysplasia.

LAMB2 LAMC3

3.82e-07222222961762
Pubmed

Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina.

LAMB2 LAMC3

2.29e-06422221283711
Pubmed

Human colonic cancer cells synthesize and adhere to laminin-5. Their adhesion to laminin-5 involves multiple receptors among which is integrin alpha2beta1.

LAMB2 LAMC3

2.29e-0642229645947
Pubmed

Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis.

LAMB2 LAMC3

3.82e-06522216581764
Pubmed

Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3).

LAMB2 LAMC3

3.82e-06522211964076
Pubmed

CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.

LCE4A LCE3C

8.01e-06722236804407
Pubmed

A new nomenclature for the laminins.

LAMB2 LAMC3

8.01e-0672227921537
Pubmed

Regional differences in the expression of laminin isoforms during mouse neural tube development.

LAMB2 LAMC3

2.09e-051122221524702
Pubmed

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

LAMB2 LAMC3

2.09e-051122223472759
Pubmed

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

LAMB2 LAMC3

2.51e-051222226794322
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SHROOM4 FBXO40 ANKFY1

3.73e-0510322310574462
Pubmed

Basement membrane composition in the early mouse embryo day 7.

LAMB2 LAMC3

3.99e-051522215895400
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMB2 LAMC3

4.56e-051622217601529
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMB2 LAMC3

5.81e-051822211311202
Pubmed

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

LAMB2 LAMC3

7.21e-052022222911573
Pubmed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

LCE4A LCE3C

8.76e-052222215854049
Pubmed

Differentially expressed late constituents of the epidermal cornified envelope.

LCE4A LCE3C

9.59e-052322211698679
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

LAMB2 LAMC3

1.23e-042622224742657
InteractionHOXA1 interactions

YPEL3 LAMB2 LCE4A LPXN LCE3C

2.70e-05356215int:HOXA1
InteractionPLSCR4 interactions

YPEL3 ZDHHC13 LPXN

6.27e-0575213int:PLSCR4
InteractionKRTAP3-3 interactions

YPEL3 LCE4A LCE3C

8.19e-0582213int:KRTAP3-3
Cytoband1p36.33

TMEM240 MXRA8

6.28e-04772221p36.33
Cytoband1q21.3

LCE4A LCE3C

1.44e-031172221q21.3
Cytoband16p11.2

YPEL3 EIF3CL

3.77e-0319122216p11.2
CytobandEnsembl 112 genes in cytogenetic band chr1p36

TMEM240 MASP2 MXRA8

4.06e-03681223chr1p36
CytobandEnsembl 112 genes in cytogenetic band chr1q21

LCE4A LCE3C

1.59e-02404222chr1q21
GeneFamilyNetrins

NTN5 NTN3

1.25e-056172661
GeneFamilyLaminin subunits

LAMB2 LAMC3

5.46e-0512172626
GeneFamilyLate cornified envelope proteins

LCE4A LCE3C

1.26e-0418172627
CoexpressionNABA_BASEMENT_MEMBRANES

NTN5 LAMB2 LAMC3 NTN3

2.73e-0840214M5887
CoexpressionNABA_ECM_GLYCOPROTEINS

NTN5 LAMB2 LAMC3 NTN3

1.48e-05191214MM17059
CoexpressionNABA_ECM_GLYCOPROTEINS

NTN5 LAMB2 LAMC3 NTN3

1.64e-05196214M3008
CoexpressionNABA_CORE_MATRISOME

NTN5 LAMB2 LAMC3 NTN3

5.74e-05270214MM17057
CoexpressionNABA_CORE_MATRISOME

NTN5 LAMB2 LAMC3 NTN3

6.16e-05275214M5884
ToppCellfacs-Thymus-nan-3m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPRID1 SHROOM4 LAMC3

4.35e-05140223115bd770a9d5e6f007a9aa0eadf5dba46d500107
ToppCellfacs-Thymus-nan-3m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPRID1 SHROOM4 LAMC3

4.35e-0514022322d126e80bf7d9c0ca6ec686b5cc66fa584a1ab6
ToppCellfacs-Thymus-nan-3m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITPRID1 SHROOM4 LAMC3

4.35e-0514022362d1ef8cb78618ed89cac7ec89d7f54de06a90c7
ToppCelldroplet-Heart-4Chambers-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 SIM1 LCE3C

5.23e-0514922338890ddde0979977c8350f01497f1245ab51641a
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMB2 LAMC3 MXRA8

6.35e-0515922334c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTN5 MASP2 SIM1

6.71e-05162223966df4558140c3d541999ab553f201ae76a1c401
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTN5 MASP2 SIM1

6.71e-0516222322f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMB2 LAMC3 MXRA8

7.88e-051712232e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMB2 LAMC3 MXRA8

7.88e-05171223e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCellSubstantia_nigra-Endothelial|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

LAMB2 LAMC3 MXRA8

1.06e-04189223bef8234bd9c4d6e3cdef0791d8066b39ba56ebba
ToppCellStriatum-Endothelial|Striatum / BrainAtlas - Mouse McCarroll V32

LAMB2 LAMC3 MXRA8

1.06e-0418922395ee3b6d7fbbfcf91c780dfcd0926acec05f0a2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB2 LAMC3 MXRA8

1.09e-04191223b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB2 LAMC3 MXRA8

1.09e-04191223cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

LAMB2 LAMC3 MXRA8

1.11e-0419222336deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellLAM-LAM|LAM / Condition, Lineage and Cell class

FBXO40 LAMC3 MXRA8

1.14e-041942234c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCellLAM-LAM-LAM+|LAM / Condition, Lineage and Cell class

FBXO40 LAMC3 MXRA8

1.14e-041942234ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PKD1L3 YPEL3 UNC80

1.16e-0419522319853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellPosterior_cortex-Endothelial|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LAMB2 LAMC3 MXRA8

1.16e-04195223988e3449691cc228cb55e5e30355136c97b12262
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PKD1L3 YPEL3 UNC80

1.16e-04195223d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LAMB2 LAMC3 MXRA8

1.18e-0419622373f029d2b276776d6c24356b14c6592c9cb74bd5
DiseaseAutism Spectrum Disorders

LAMC3 UNC80

1.51e-0385202C1510586
Diseaseage at menarche

NTN5 UNC80 SIM1

7.17e-03594203EFO_0004703

Protein segments in the cluster

PeptideGeneStartEntry
TRKHHCRHCGRLLCH

ANKFY1

1121

Q9P2R3
CICCHHHPHCHGERQ

ITPRID1

806

Q6ZRS4
CHSHVLAHAYCLHLE

OR51G1

171

Q8NGK1
SHACRKCECHGHTHS

LAMB2

341

P55268
FCELHYHHRRGTLCH

LPXN

316

O60711
CRHNTAGRHCHYCRE

NTN3

341

O00634
RTCAILCHIYHHALH

EIF3CL

566

B5ME19
HHRHCEGCFNRHCHI

FBXO40

11

Q9UH90
TCDHHCHNHLGGFYC

MASP2

151

O00187
GCCLSHHRHFRSHQC

LCE3C

51

Q5T5A8
GGCCLSHHRHHRSHC

LCE4A

56

Q5TA78
RCRHHTAGRHCHYCQ

NTN5

241

Q8WTR8
PENHHHFCCYLHRVL

PKD1L3

1066

Q7Z443
YHHVHGCDTFHLRCA

SIM1

266

P81133
CHHHQCIRCSVCYHN

SHROOM4

926

Q9ULL8
DRVCHCNCGRHHIHY

TMEM240

46

Q5SV17
HVDYCHPHCYLHHSR

UNC80

1476

Q8N2C7
HCHVCNCCVARYDQH

ZDHHC13

441

Q8IUH4
LRLCAEHGHHRACVH

VPS18

701

Q9P253
DCHRRYSCAHCRAHL

YPEL3

16

P61236
RCHHCRDHTAGPHCE

LAMC3

351

Q9Y6N6
SCHLHHHYCGLHERR

MXRA8

271

Q9BRK3