Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.41e-20	114	65	15	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.26e-20	124	65	15	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.48e-19	137	65	15	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.35e-17	192	65	15	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 MST1L USP17L22 USP17L15 USP17L13 USP17L18	2.13e-10	654	65	16	GO:0008233
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	EHMT2 MECOM PRDM16	1.82e-06	8	65	3	GO:0140948
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	EHMT2 MECOM PRDM16	3.89e-06	10	65	3	GO:0140947
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	EHMT2 MECOM PRDM16	9.20e-06	13	65	3	GO:0046974
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	EHMT2 MECOM PRDM16	3.96e-04	44	65	3	GO:0140938
GeneOntologyMolecularFunction	ribonuclease P activity	POP1 PRORP	6.74e-04	12	65	2	GO:0004526
GeneOntologyMolecularFunction	tRNA-specific ribonuclease activity	POP1 PRORP	1.37e-03	17	65	2	GO:0004549
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	EHMT2 MECOM PRDM16	1.42e-03	68	65	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	EHMT2 MECOM PRDM16	1.48e-03	69	65	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	EHMT2 MECOM PRDM16	1.61e-03	71	65	3	GO:0042054
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC21 ZDHHC3	3.22e-03	26	65	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC21 ZDHHC3	3.22e-03	26	65	2	GO:0019707
GeneOntologyMolecularFunction	hyaluronic acid binding	USP17L24 USP17L6P	4.00e-03	29	65	2	GO:0005540
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC21 ZDHHC3	4.28e-03	30	65	2	GO:0016417
GeneOntologyMolecularFunction	protein methyltransferase activity	EHMT2 MECOM PRDM16	4.62e-03	103	65	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	EHMT2 MECOM PRDM16	4.87e-03	105	65	3	GO:0008170
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.24e-18	125	63	14	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	9.57e-18	144	63	14	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 KLHL25 USP17L12 USP17L17 USP17L20 TRIM26 USP17L11 USP17L24 USP17L6P USP17L5 RNF213 USP17L10 TNKS USP17L19 USP17L22 ZNF598 USP17L15 USP17L13 USP17L18	8.43e-11	1009	63	19	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L21 KLHL25 USP17L12 USP17L17 USP17L20 TRIM26 USP17L11 USP17L24 USP17L6P USP17L5 RNF213 USP17L10 TNKS USP17L19 USP17L22 ZNF598 USP17L15 USP17L13 USP17L18	2.43e-10	1074	63	19	GO:0043687
GeneOntologyBiologicalProcess	endolysosomal toll-like receptor signaling pathway	TNIP2 TLR3 TLR7 ZDHHC3	2.58e-05	56	63	4	GO:0140894
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L21 USP17L12 RDH16 SMIM14 USP17L17 USP17L20 USP17L11 TLR3 USP17L6P USP17L5 USP17L10 TLR7 USP17L19 USP17L22 USP17L15 TMCC3 USP17L13 USP17L18	2.81e-08	1293	63	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L21 USP17L12 RDH16 SMIM14 USP17L17 USP17L20 USP17L11 TLR3 USP17L6P USP17L5 USP17L10 TLR7 USP17L19 USP17L22 USP17L15 TMCC3 USP17L13 USP17L18	3.02e-08	1299	63	18	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L21 USP17L12 RDH16 SMIM14 USP17L17 USP17L20 USP17L11 TLR3 USP17L6P USP17L5 USP17L10 TLR7 USP17L19 USP17L22 USP17L15 TMCC3 USP17L13 USP17L18	4.18e-08	1327	63	18	GO:0042175
GeneOntologyCellularComponent	ribonuclease P complex	POP1 PRORP	7.95e-04	14	63	2	GO:0030677
GeneOntologyCellularComponent	endolysosome membrane	TLR3 TLR7	1.64e-03	20	63	2	GO:0036020
HumanPheno	Optic neuritis	TLR7 PRORP KLRC4	1.72e-05	23	12	3	HP:0100653
HumanPheno	Neuroinflammation	TLR7 PRORP KLRC4	1.72e-05	23	12	3	HP:0033429
HumanPheno	Glomerulonephritis	LAMB2 TLR7 NUP93 KLRC4	9.24e-05	111	12	4	HP:0000099
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	7.49e-25	16	61	11	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	7.49e-25	16	61	11	IPR006861
Domain	USP_CS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	2.01e-18	66	61	12	IPR018200
Domain	USP_1	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	4.30e-18	70	61	12	PS00972
Domain	UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	5.16e-18	71	61	12	PF00443
Domain	USP_2	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	5.16e-18	71	61	12	PS00973
Domain	USP_3	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.17e-18	72	61	12	PS50235
Domain	USP_dom	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.17e-18	72	61	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L22 USP17L13 USP17L18	6.17e-18	72	61	12	IPR001394
Domain	Evi1/Prdm16	MECOM PRDM16	1.05e-05	2	61	2	IPR030413
Domain	ZINC_FINGER_C2H2_2	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	8.71e-04	775	61	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	8.87e-04	777	61	9	PS00028
Domain	Znf_C2H2-like	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	1.05e-03	796	61	9	IPR015880
Domain	Znf_C2H2	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	1.14e-03	805	61	9	IPR007087
Domain	ZnF_C2H2	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	1.17e-03	808	61	9	SM00355
Domain	-	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 PRDM16 ZNF441 ZNF222	1.57e-03	679	61	8	3.30.160.60
Domain	zf-C2H2	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 PRDM16 ZNF441 ZNF222	1.79e-03	693	61	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 PRDM16 ZNF441 ZNF222	1.81e-03	694	61	8	IPR013087
Domain	TIR	TLR3 TLR7	2.12e-03	21	61	2	SM00255
Domain	TIR	TLR3 TLR7	2.32e-03	22	61	2	PF01582
Domain	-	TLR3 TLR7	2.54e-03	23	61	2	3.40.50.10140
Domain	zf-DHHC	ZDHHC21 ZDHHC3	2.54e-03	23	61	2	PF01529
Domain	TIR	TLR3 TLR7	2.77e-03	24	61	2	PS50104
Domain	DHHC	ZDHHC21 ZDHHC3	3.00e-03	25	61	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC21 ZDHHC3	3.00e-03	25	61	2	IPR001594
Domain	TIR_dom	TLR3 TLR7	3.00e-03	25	61	2	IPR000157
Domain	Galactose-bd-like	CEP104 MKLN1 LAMB2	3.60e-03	94	61	3	IPR008979
Domain	FYVE	ZFYVE28 HGS	4.02e-03	29	61	2	PF01363
Domain	FYVE	ZFYVE28 HGS	4.02e-03	29	61	2	SM00064
Domain	LRRCT	TLR3 TLR7	4.89e-03	32	61	2	PF01463
Domain	Znf_FYVE-rel	ZFYVE28 HGS	5.50e-03	34	61	2	IPR017455
Domain	KRAB	ZNF14 ZNF221 ZNF223 ZNF441 ZNF222	6.22e-03	358	61	5	PS50805
Domain	KRAB	ZNF14 ZNF221 ZNF223 ZNF441 ZNF222	6.22e-03	358	61	5	PF01352
Domain	Znf_FYVE	ZFYVE28 HGS	6.84e-03	38	61	2	IPR000306
Domain	KRAB	ZNF14 ZNF221 ZNF223 ZNF441 ZNF222	7.05e-03	369	61	5	SM00349
Domain	KRAB	ZNF14 ZNF221 ZNF223 ZNF441 ZNF222	7.13e-03	370	61	5	IPR001909
Domain	ZF_FYVE	ZFYVE28 HGS	7.56e-03	40	61	2	PS50178
Domain	SET	EHMT2 PRDM16	9.90e-03	46	61	2	SM00317
Domain	-	KLHL25 MKLN1	1.07e-02	48	61	2	2.120.10.80
Domain	SET_dom	EHMT2 PRDM16	1.16e-02	50	61	2	IPR001214
Domain	SET	EHMT2 PRDM16	1.16e-02	50	61	2	PS50280
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.07e-22	45	53	13	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 HGS USP17L6P USP17L5 USP17L10 TNKS USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.18e-16	191	53	15	MM15289
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 TNIP2 HGS USP17L6P USP17L5 USP17L10 TNKS USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.03e-15	262	53	16	MM15286
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 HGS USP17L24 USP17L5 USP17L10 TNKS USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.95e-15	221	53	15	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 TNIP2 HGS USP17L24 USP17L5 USP17L10 TNKS USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.24e-15	299	53	16	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.15e-10	318	53	13	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 KLHL25 USP17L12 USP17L17 USP17L20 USP17L11 TNIP2 HGS USP17L24 LAMB2 USP17L5 USP17L10 TNKS USP17L19 NUP93 USP17L22 USP17L15 USP17L13 USP17L18	7.64e-07	1475	53	19	M19806
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 KLHL25 USP17L12 USP17L17 USP17L20 USP17L11 TNIP2 HGS USP17L6P USP17L5 USP17L10 TNKS USP17L19 NUP93 USP17L22 USP17L15 USP17L13 USP17L18	1.54e-06	1389	53	18	MM15307
Pathway	WP_MRNA_VACCINE_ACTIVATION_OF_DENDRITIC_CELL_AND_INDUCTION_OF_IFN1	TLR3 TLR7	6.12e-04	10	53	2	M45510
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.36e-31	21	66	13	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.75e-31	22	66	13	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.42e-30	33	66	14	20228807
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	15780755
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.42e-30	34	66	14	21448158
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.88e-30	24	66	13	8995226
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.02e-30	35	66	14	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.02e-30	35	66	14	16611142
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	5.99e-30	25	66	13	21115691
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	6.58e-30	36	66	14	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.06e-29	37	66	14	20228808
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.20e-29	26	66	13	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	7.77e-29	29	66	13	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	3.95e-25	50	66	13	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 ZBTB7C USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.82e-11	674	66	14	37196079
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	3.03e-09	119	66	7	28625976
Pubmed	High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML.	MECOM PRDM16	3.55e-06	2	66	2	25567132
Pubmed	Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts.	TLR3 TLR7	3.55e-06	2	66	2	27586271
Pubmed	Toll-like receptors 3 and 7 agonists enhance tumor cell lysis by human gammadelta T cells.	TLR3 TLR7	3.55e-06	2	66	2	19887600
Pubmed	Plasmacytoid dendritic cells regulate colitis-associated tumorigenesis by controlling myeloid-derived suppressor cell infiltration.	TLR3 TLR7	3.55e-06	2	66	2	32810576
Pubmed	Type I IFN-mediated synergistic activation of mouse and human DC subsets by TLR agonists.	TLR3 TLR7	3.55e-06	2	66	2	26255864
Pubmed	Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-κB signaling pathway.	TLR3 TLR7	3.55e-06	2	66	2	27046485
Pubmed	TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.	TLR3 TLR7	3.55e-06	2	66	2	16105838
Pubmed	TLR3\TLR7 as Differentially Expressed Markers Among Viral, Nonviral, and Autoimmune Diseases in Egyptian Patients.	TLR3 TLR7	3.55e-06	2	66	2	34342515
Pubmed	U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7.	TLR3 TLR7	3.55e-06	2	66	2	16368889
Pubmed	A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells.	MECOM PRDM16	3.55e-06	2	66	2	11050005
Pubmed	Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.	TLR3 TLR7	3.55e-06	2	66	2	30906301
Pubmed	Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma.	TLR3 TLR7	3.55e-06	2	66	2	37133342
Pubmed	Upregulation of TLR7 and TLR3 gene expression in the lung of respiratory syncytial virus infected mice.	TLR3 TLR7	3.55e-06	2	66	2	19445181
Pubmed	Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo.	TLR3 TLR7	3.55e-06	2	66	2	16537810
Pubmed	Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.	TLR3 TLR7	3.55e-06	2	66	2	34161582
Pubmed	RNA receptors, TLR3 and TLR7, are potentially associated with SLE clinical features.	TLR3 TLR7	3.55e-06	2	66	2	33650302
Pubmed	Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines.	TLR3 TLR7	3.55e-06	2	66	2	20309865
Pubmed	Association of TLR3 gene 1377C/T (rs3775290) and TLR7 gene C/G (rs3853839) polymorphism with hand, foot, and mouth disease caused by human enterovirus 71 infection susceptibility and severity in the Chinese Han population: A meta-analysis of case-control studies.	TLR3 TLR7	3.55e-06	2	66	2	35801751
Pubmed	Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.	TLR3 TLR7	3.55e-06	2	66	2	25539593
Pubmed	Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production.	TLR3 TLR7	3.55e-06	2	66	2	27084119
Pubmed	Activation of autoreactive B cells by endogenous TLR7 and TLR3 RNA ligands.	TLR3 TLR7	3.55e-06	2	66	2	23019335
Pubmed	Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.	MECOM PRDM16	3.55e-06	2	66	2	18496560
Pubmed	Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells.	MECOM PRDM16	3.55e-06	2	66	2	16109773
Pubmed	Prognostic impact of toll-like receptors gene polymorphism on outcome of COVID-19 pneumonia: A case-control study.	TLR3 TLR7	3.55e-06	2	66	2	35063671
Pubmed	Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice.	TLR3 TLR7	3.55e-06	2	66	2	26581984
Pubmed	Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.	ZNF221 ZNF223 ZNF222	7.27e-06	20	66	3	12743021
Pubmed	Vitamin D3 Alters the Expression of Toll-like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus.	TLR3 TLR7	1.06e-05	3	66	2	28544067
Pubmed	Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758.	TLR3 TLR7	1.06e-05	3	66	2	25008898
Pubmed	Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.	MECOM PRDM16	1.06e-05	3	66	2	32437910
Pubmed	Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma.	TLR3 TLR7	1.06e-05	3	66	2	15634897
Pubmed	Respiratory macrophages and dendritic cells mediate respiratory syncytial virus-induced IL-33 production in TLR3- or TLR7-dependent manner.	TLR3 TLR7	1.06e-05	3	66	2	26603638
Pubmed	EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization.	EHMT2 MECOM	1.06e-05	3	66	2	19776757
Pubmed	Cervical cancer cell supernatants induce a phenotypic switch from U937-derived macrophage-activated M1 state into M2-like suppressor phenotype with change in Toll-like receptor profile.	TLR3 TLR7	1.06e-05	3	66	2	25309919
Pubmed	The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development.	MECOM PRDM16	1.06e-05	3	66	2	32044379
Pubmed	The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.	TLR3 TLR7	1.06e-05	3	66	2	29947302
Pubmed	Toll-like receptor 3 and 7/8 function is impaired in hepatitis C rapid fibrosis progression post-liver transplantation.	TLR3 TLR7	1.06e-05	3	66	2	23425350
Pubmed	Immunoadjuvant effects of polyadenylic:polyuridylic acids through TLR3 and TLR7.	TLR3 TLR7	1.06e-05	3	66	2	17981792
Pubmed	Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population.	TLR3 TLR7	1.06e-05	3	66	2	24445780
Pubmed	Expression of toll-like receptors 3, 7, and 9 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.	TLR3 TLR7	1.06e-05	3	66	2	24692849
Pubmed	Toll-like receptor polymorphisms and age-related macular degeneration.	TLR3 TLR7	1.06e-05	3	66	2	18385087
Pubmed	Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.	TLR3 TLR7	1.06e-05	3	66	2	16111635
Pubmed	Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.	MECOM PRDM16	1.06e-05	3	66	2	16582916
Pubmed	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.	TLR3 TLR7	1.06e-05	3	66	2	28300057
Pubmed	B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.	TLR3 TLR7	1.06e-05	3	66	2	23761632
Pubmed	In vivo liver expression of TLR2, TLR3 and TLR7 in chronic hepatitis C.	TLR3 TLR7	1.06e-05	3	66	2	23489702
Pubmed	TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.	TLR3 TLR7	1.06e-05	3	66	2	22565312
Pubmed	Cryo-EM structures of Toll-like receptors in complex with UNC93B1.	TLR3 TLR7	1.06e-05	3	66	2	33432245
Pubmed	Toll-like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma.	TLR3 TLR7	1.06e-05	3	66	2	25912131
Pubmed	Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses.	TLR3 TLR7	1.06e-05	3	66	2	16935934
Pubmed	Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV.	TLR3 TLR7	1.06e-05	3	66	2	30321082
Pubmed	Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes.	HGS TLR3	1.06e-05	3	66	2	31089414
Pubmed	Modulation of TLR 3, 7 and 8 expressions in HCV genotype 3 infected individuals: potential correlations of pathogenesis and spontaneous clearance.	TLR3 TLR7	1.06e-05	3	66	2	25126563
Pubmed	Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.	TLR3 TLR7	1.06e-05	3	66	2	18021446
Pubmed	Contribution of Toll like receptor polymorphisms to dengue susceptibility and clinical outcome among eastern Indian patients.	TLR3 TLR7	1.06e-05	3	66	2	31481269
Pubmed	TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells.	TLR3 TLR7	1.06e-05	3	66	2	15210814
Pubmed	Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.	TLR3 TLR7	1.06e-05	3	66	2	27405980
Pubmed	Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41.	ZNF221 ZNF223	1.06e-05	3	66	2	10449920
Pubmed	Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants.	TLR3 TLR7	1.06e-05	3	66	2	27729782
Pubmed	MAVS mediates a protective immune response in the brain to Rift Valley fever virus.	TLR3 TLR7	1.06e-05	3	66	2	35584192
Pubmed	Expression of IL-27 p28 by Theiler's virus-infected macrophages depends on TLR3 and TLR7 activation of JNK-MAP-kinases.	TLR3 TLR7	1.06e-05	3	66	2	17675254
Pubmed	Genetically defined variants of toll-like receptors 3, 7 and 9 as phenotype and risk modifier factors for psoriasis.	TLR3 TLR7	1.06e-05	3	66	2	29290528
Pubmed	Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells.	TLR3 TLR7	1.06e-05	3	66	2	19559490
Pubmed	The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.	TLR3 TLR7	1.06e-05	3	66	2	29768176
Pubmed	Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.	TLR3 TLR7	1.06e-05	3	66	2	37020259
Pubmed	A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a.	EHMT2 MECOM	1.06e-05	3	66	2	18619962
Pubmed	Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7.	TLR3 TLR7	1.06e-05	3	66	2	34211474
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	EHMT2 TRIM26 POP1 MKLN1 MECOM NUP93	1.63e-05	282	66	6	23667531
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	EHMT2 TRIM26 FAM167A MECOM RNF213 AKAP13 NUP93 ZNF598	1.81e-05	601	66	8	33658012
Pubmed	Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma.	TLR3 TLR7	2.12e-05	4	66	2	21990957
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 RNF213 USP17L19 NUP93 USP17L18	3.95e-07	318	60	9	int:FLT3
Cytoband	4p16.1	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.09e-28	79	66	15	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	ZFYVE28 USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 TNIP2 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.73e-25	222	66	17	chr4p16
Cytoband	16q13	NLRC5 NUP93	1.24e-03	36	66	2	16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	NLRC5 NUP93	1.53e-03	40	66	2	chr16q13
Cytoband	19q13.2	ZNF221 ZNF223 ZNF222	1.74e-03	164	66	3	19q13.2
Cytoband	4p16.3	ZFYVE28 TNIP2	6.73e-03	85	66	2	4p16.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF14 ZBTB7C MECOM ZNF221 ZNF223 ZNF598 PRDM16 ZNF441 ZNF222	1.07e-05	718	37	9	28
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	EHMT2 MECOM PRDM16	4.52e-05	34	37	3	487
GeneFamily	CD molecules\|Toll like receptors	TLR3 TLR7	1.81e-04	10	37	2	948
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	MECOM PRDM16	5.44e-04	17	37	2	1197
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC21 ZDHHC3	1.09e-03	24	37	2	76
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE28 HGS	1.83e-03	31	37	2	81
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.27e-20	86	64	13	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	8.45e-19	112	64	13	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.00e-16	160	64	13	MM1155
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	ROCK2 USP17L21 USP17L12 SMIM14 USP17L17 USP17L20 USP17L11 USP17L6P SSMEM1 USP17L5 CCL1 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.96e-10	1072	64	17	MM1031
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.64e-09	647	64	13	MM981
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 GJB5 USP17L12 USP17L17 USP17L20 USP17L11 USP17L6P USP17L5 USP17L10 TMEM183BP USP17L19 NUP93 USP17L22 USP17L15 USP17L13 USP17L18	2.02e-08	1198	64	16	MM1062
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	CEP104 USP17L21 KLHL25 USP17L12 USP17L17 USP17L20 USP17L11 TLR3 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.78e-08	1226	64	16	MM979
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_10H_DN	TRIM26 MKLN1 NLRC5 RNF213 TMCC3 MXD1	9.50e-06	200	64	6	M4269
Coexpression	GIAROLA_SILVA_BLOOD_PANDEMRIX_AGE_21_51YO_3DY_UP	TLR3 TLR7	5.84e-05	5	64	2	M41182
Coexpression	GIAROLA_SILVA_BLOOD_INFLUENZA_A_AGE_21_51YO_3DY_UP	TLR3 TLR7	5.84e-05	5	64	2	M41181
Coexpression	GSE18893_TCONV_VS_TREG_2H_TNF_STIM_DN	ZFYVE28 SMIM14 AKAP13 TMCC3 ZNF222	1.13e-04	194	64	5	M7306
Coexpression	GSE3720_VD1_VS_VD2_GAMMADELTA_TCELL_UP	POP1 MECOM RNF213 CCL1 TLR7	1.24e-04	198	64	5	M6361
Coexpression	GSE18791_CTRL_VS_NEWCASTLE_VIRUS_DC_12H_DN	TRIM26 MKLN1 NLRC5 RNF213 TMCC3	1.24e-04	198	64	5	M4272
Coexpression	GSE28737_WT_VS_BCL6_HET_FOLLICULAR_BCELL_UP	ROCK2 KLHL25 PDE7A TRIM26 HGS	1.30e-04	200	64	5	M9391
Coexpression	GSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY7_DN	RDH16 CBX6 TNIP2 HGS POP1	1.30e-04	200	64	5	M6585
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	2.52e-27	46	64	14	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	1.56e-24	69	64	14	DOID:1682 (implicated_via_orthology)
Disease	smoking status measurement, systolic blood pressure	EHMT2 FAM167A MECOM TNKS	3.73e-04	156	64	4	EFO_0006335, EFO_0006527
Disease	sex interaction measurement, ulcerative colitis	EHMT2 TRIM26	6.17e-04	17	64	2	EFO_0000729, EFO_0008343
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR3 TLR7	6.17e-04	17	64	2	DOID:8677 (biomarker_via_orthology)
Disease	migraine disorder, Headache	RDH16 RNF213 PRDM16	8.76e-04	86	64	3	HP_0002315, MONDO_0005277
Disease	smoking status measurement, chronic obstructive pulmonary disease	EHMT2 TRIM26 MECOM	9.36e-04	88	64	3	EFO_0000341, EFO_0006527
Disease	anogenital venereal wart (is_marker_for)	TLR3 TLR7	1.46e-03	26	64	2	DOID:11168 (is_marker_for)
Disease	cytotoxicity measurement, response to clozapine	CCL1 TMCC3	1.81e-03	29	64	2	EFO_0006952, GO_0097338
Disease	nicotine dependence symptom count	ZFYVE28 SPOCK3 PRDM16 TMCC3	3.44e-03	285	64	4	EFO_0009262
Disease	systolic blood pressure, alcohol consumption measurement	FAM167A MECOM	4.70e-03	47	64	2	EFO_0006335, EFO_0007878
Disease	smoking status measurement, diastolic blood pressure	EHMT2 MECOM TNKS	5.03e-03	159	64	3	EFO_0006336, EFO_0006527

Protein segments in the cluster

Peptide	Gene	Start	Entry
VQRHRKMLRHCPSKR	CCL1	81	P22362
RMCLRHSRECLALKQ	ANTXRL	511	A6NF34
VHRLKKDIRRCHRMS	CBX6	116	O95503
REHRMFDQQICHRSK	AKAP13	1656	Q12802
CETHRARMVKHHCCP	EHMT2	481	Q96KQ7
RMERLRCHAVHVALV	NUP93	481	Q8N1F7
KHNCLQRRCMPLHSR	APELA	36	P0DMC3
TVIRRKHHCRSCGKI	ZFYVE28	831	Q9HCC9
LCRHKRMHADCRTQI	MECOM	391	Q03112
HNEMEKNRRAHLRLC	MXD1	61	Q05195
CNIKHRGHVRESEMC	MST1L	636	Q2TV78
DTRHRHLVLQMALKC	PDE7A	346	Q13946
CHCRQHMVGRRCEQV	LAMB2	541	P55268
SRRMRLTHCGLQEKH	NLRC5	976	Q86WI3
AMVILCRFRKLHCTR	ADCYAP1R1	171	P41586
CRFRKLHCTRNFIHM	ADCYAP1R1	176	P41586
NKCHKARRCHMNRTL	POP1	176	Q99575
HCLMLTRCDHCKQVV	CEP104	776	O60308
CVLAHLNTLRKHCMF	KLHL25	31	Q9H0H3
LKRHHARMQLLRKCS	FNDC11	61	Q9BVV2
LHHSMCTRKRHRRCE	LYST	491	Q99698
KRCHECLAARKAQAM	GJB5	211	O95377
SLNRRMQKARHCGHC	KLRC4	106	O43908
LKIEHTCRLHRRMLN	FAM167A	151	Q96KS9
HRCKSRVERHDMNTL	TMCC3	21	Q9ULS5
RSCHKMCIDIQRRQI	MKLN1	326	Q9UL63
RIGHCMLFHSKNRCL	MKLN1	456	Q9UL63
NCMEHALIACHPRTR	RDH16	266	O75452
YQMSERHCLHCKALR	SSMEM1	191	Q8WWF3
LHCLRACVIRSLYHM	TMEM183BP	196	Q1AE95
FSNLCRHKRMHADCR	PRDM16	406	Q9HAZ2
RHKRMHADCRTQIKC	PRDM16	411	Q9HAZ2
CVCSHEHAMRRLINL	SMIM14	11	Q96QK8
NHCRFITRDLMRDHK	PRORP	491	O15091
NCGSIERHQKRHLMR	C15orf32	146	Q32M92
TAHMCQHLAKCLDER	TNIP2	161	Q8NFZ5
HREAIEKHARFRQMC	RNF213	4051	Q63HN8
RRNLRCHMVERACEI	ZNF441	61	Q8N8Z8
NHALCLRRGMFKSHC	TLR3	861	O15455
FRCRSALTVHCKLHM	ZNF223	241	Q9UK11
HHCSVCKRCIRKMDH	ZDHHC3	141	Q9NYG2
THKDRSCYICHRQML	TNKS	1236	O95271
REHSQTCHRHKGCML	USP17L18	111	D6R9N7
CHRCRVQFGVMTRKH	HGS	166	O14964
REHSQTCHRHKGCML	USP17L5	111	A8MUK1
REHSQTCHRHKGCML	USP17L21	111	D6R901
REHSQTCHRHKGCML	USP17L13	111	C9JLJ4
LECRRCHIKCHKDHM	ROCK2	1291	O75116
REHSQTCHRHKGCML	USP17L19	111	D6RCP7
CVMCRESREHRPHTA	TRIM26	121	Q12899
KMLLLHHNRFLCTCD	TLR7	776	Q9NYK1
CISHRRLTHRMKEAG	SPOCK3	111	Q9BQ16
LCNKCNLMRPKRSHH	ZDHHC21	91	Q8IVQ6
QHMRRQHELFCCRLC	ZNF598	136	Q86UK7
REHSQTCHRHKGCML	USP17L12	111	C9JPN9
DHLHRHIKRQSCRMA	ZBTB7C	461	A1YPR0
ICRRDFCKHQMVHTG	ZNF221	376	Q9UK13
REHSQTCHRHKGCML	USP17L24	111	Q0WX57
REHSQTCHRHKGCML	USP17L6P	111	Q6QN14
REHSQTCHRHKGCML	USP17L22	111	D6RA61
REHSQTCHRHKGCML	USP17L15	111	C9J2P7
REHSQTCHRHKGCML	USP17L17	111	D6RBQ6
REHSQTCHRHKGCML	USP17L23	111	D6RBM5
REHSQTCHRHKGCML	USP17L20	111	D6RJB6
RCRSALKVHCKLHMR	ZNF222	211	Q9UK12
REHSQTCHRHKGCML	USP17L10	111	C9JJH3
ACDQLHFCRRHMLGK	ZC3HAV1L	101	Q96H79
HRNQGKNRRCHMVER	ZNF14	56	P17017
REHSQTCHRHKGCML	USP17L11	111	C9JVI0