Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionasparagine-tRNA ligase activity

NARS1 NARS2

1.08e-052662GO:0004816
GeneOntologyMolecularFunction5-diphosphoinositol pentakisphosphate 1-kinase activity

PPIP5K1 PPIP5K2

1.08e-052662GO:0033857
GeneOntologyMolecularFunctionnitric-oxide synthase activity

NOS1 NOS3

3.22e-053662GO:0004517
GeneOntologyMolecularFunctiontetrahydrobiopterin binding

NOS1 NOS3

6.43e-054662GO:0034617
GeneOntologyMolecularFunctioninositol hexakisphosphate 3-kinase activity

PPIP5K1 PPIP5K2

6.43e-054662GO:0052724
GeneOntologyMolecularFunctioninositol hexakisphosphate 1-kinase activity

PPIP5K1 PPIP5K2

6.43e-054662GO:0052723
GeneOntologyMolecularFunctioninositol hexakisphosphate 5-kinase activity

PPIP5K1 PPIP5K2

1.07e-045662GO:0000832
GeneOntologyMolecularFunctiondiphosphoinositol pentakisphosphate kinase activity

PPIP5K1 PPIP5K2

1.07e-045662GO:0000829
GeneOntologyMolecularFunctioninositol hexakisphosphate kinase activity

PPIP5K1 PPIP5K2

1.07e-045662GO:0000828
GeneOntologyMolecularFunctioninositol-1,3,4,5,6-pentakisphosphate kinase activity

PPIP5K1 PPIP5K2

1.07e-045662GO:0000827
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

MARS2 NARS1 NARS2

3.61e-0442663GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

MARS2 NARS1 NARS2

3.61e-0442663GO:0004812
GeneOntologyMolecularFunctionarginine binding

NOS1 NOS3

3.82e-049662GO:0034618
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP11B1 CYP26C1 OGFOD2 NOS1 NOS3

4.55e-04194665GO:0016705
GeneOntologyMolecularFunctionmonooxygenase activity

CYP11B1 CYP26C1 NOS1 NOS3

5.71e-04115664GO:0004497
GeneOntologyMolecularFunctioninositol phosphate kinase activity

PPIP5K1 PPIP5K2

5.81e-0411662GO:0180030
GeneOntologyMolecularFunctioncadmium ion binding

NOS1 NOS3

6.95e-0412662GO:0046870
GeneOntologyMolecularFunctionFMN binding

NOS1 NOS3

1.25e-0316662GO:0010181
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

MARS2 POP5 NARS1 NARS2

1.32e-03144664GO:0140101
GeneOntologyMolecularFunctiontransition metal ion binding

RTL3 CYP11B1 CYP26C1 OGFOD2 ADAMTS20 KMT2A NUDT8 ZNF593 NOS1 NOS3 ZCCHC3

1.67e-0311896611GO:0046914
GeneOntologyMolecularFunctionheme binding

CYP11B1 CYP26C1 NOS1 NOS3

1.69e-03154664GO:0020037
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP11B1 CYP26C1 NOS1 NOS3

2.13e-03164664GO:0046906
GeneOntologyMolecularFunctionfibroblast growth factor receptor binding

FGF2 FGF9

4.12e-0329662GO:0005104
GeneOntologyBiologicalProcessasparaginyl-tRNA aminoacylation

NARS1 NARS2

2.58e-053612GO:0006421
GeneOntologyCellularComponentI-kappaB/NF-kappaB complex

NFKB1 NFKB2

5.69e-054652GO:0033256
MousePhenoabnormal cerebral blood flow rate

NOS1 NOS3

1.46e-052542MP:0031182
MousePhenoabnormal brain blood flow rate

NOS1 NOS3

4.38e-053542MP:0031179
DomainIPT

NFKB1 NFKB2 PKHD1L1 PLXNB3

2.35e-0627664SM00429
DomainIPT

NFKB1 NFKB2 PKHD1L1 PLXNB3

4.75e-0632664IPR002909
DomainCAPS

CADPS CADPS2

1.23e-052662IPR033227
DomainAsn-tRNA-ligase

NARS1 NARS2

1.23e-052662IPR004522
Domain-

NOS1 NOS3

3.68e-0536623.90.340.10
DomainNO_synthase

NOS1 NOS3

3.68e-053662PF02898
DomainNOS_N

NOS1 NOS3

3.68e-053662IPR004030
DomainNOS

NOS1 NOS3

3.68e-053662PS60001
DomainNOS_euk

NOS1 NOS3

3.68e-053662IPR012144
DomainAsp/Asn-tRNA-synth_IIb

NARS1 NARS2

7.35e-054662IPR002312
Domainaa-tRNA-synt_II-like

NARS1 NARS2

1.22e-045662IPR018150
DomainRHD_CS

NFKB1 NFKB2

1.22e-045662IPR030492
Domainaa-tRNA-synt_II

NARS1 NARS2

1.22e-045662IPR004364
DomainIPT_NFkappaB

NFKB1 NFKB2

1.22e-045662IPR033926
DomaintRNA-synt_2

NARS1 NARS2

1.22e-045662PF00152
DomainDUF1041

CADPS CADPS2

1.22e-045662SM01145
DomainTIG

NFKB1 PKHD1L1 PLXNB3

1.77e-0431663PF01833
DomainAcid_Pase_AS

PPIP5K1 PPIP5K2

1.83e-046662IPR033379
DomainFAD_binding_1

NOS1 NOS3

1.83e-046662PF00667
DomainFAD-binding_1

NOS1 NOS3

1.83e-046662IPR003097
Domain-

NOS1 NOS3

1.83e-0466621.20.990.10
DomainNADPH_Cyt_P450_Rdtase_dom3

NOS1 NOS3

1.83e-046662IPR023173
DomainDUF1041

CADPS CADPS2

2.55e-047662PF06292
DomainMunc13_1

CADPS CADPS2

2.55e-047662IPR014770
DomainHIS_ACID_PHOSPHAT_2

PPIP5K1 PPIP5K2

2.55e-047662PS00778
DomainCAPS_dom

CADPS CADPS2

2.55e-047662IPR010439
DomainMHD1

CADPS CADPS2

2.55e-047662PS51258
DomainHIS_ACID_PHOSPHAT_1

PPIP5K1 PPIP5K2

2.55e-047662PS00616
DomainHis_Pase_clade-2

PPIP5K1 PPIP5K2

3.40e-048662IPR000560
DomainFLAVODOXIN_LIKE

NOS1 NOS3

3.40e-048662PS50902
DomainFlavodoxin/NO_synth

NOS1 NOS3

3.40e-048662IPR008254
DomainHis_Phos_2

PPIP5K1 PPIP5K2

3.40e-048662PF00328
DomainFlavdoxin-like

NOS1 NOS3

3.40e-048662IPR001094
DomainFlavodoxin_1

NOS1 NOS3

3.40e-048662PF00258
DomainIg_E-set

NFKB1 NFKB2 PKHD1L1 PLXNB3

5.02e-04104664IPR014756
DomainRHD_dimer

NFKB1 NFKB2

5.43e-0410662IPR032397
DomainRHD_dimer

NFKB1 NFKB2

5.43e-0410662PF16179
DomainNFkB/Dor

NFKB1 NFKB2

5.43e-0410662IPR000451
DomainREL_1

NFKB1 NFKB2

5.43e-0410662PS01204
DomainRHD_DNA_bind_dom

NFKB1 NFKB2

5.43e-0410662IPR011539
DomainFlavoprotein-like_dom

NOS1 NOS3

5.43e-0410662IPR029039
DomainRHD_DNA_bind

NFKB1 NFKB2

5.43e-0410662PF00554
DomainFlavoprot_Pyr_Nucl_cyt_Rdtase

NOS1 NOS3

5.43e-0410662IPR001709
DomainREL_2

NFKB1 NFKB2

5.43e-0410662PS50254
Domain-

NFKB1 NFKB2

5.43e-04106622.60.40.340
Domain-

NOS1 NOS3

5.43e-04106623.40.50.360
DomainOxRdtase_FAD/NAD-bd

NOS1 NOS3

7.93e-0412662IPR001433
DomaintRNA_anti-codon

NARS1 NARS2

7.93e-0412662PF01336
DomainNAD_binding_1

NOS1 NOS3

7.93e-0412662PF00175
DomainNA-bd_OB_tRNA

NARS1 NARS2

7.93e-0412662IPR004365
Domainp53-like_TF_DNA-bd

EOMES NFKB1 NFKB2

8.70e-0453663IPR008967
Domainaa-tRNA-synth_II

NARS1 NARS2

1.81e-0318662IPR006195
DomainAA_TRNA_LIGASE_II

NARS1 NARS2

1.81e-0318662PS50862
DomainFd_Rdtase_FAD-bd

NOS1 NOS3

2.02e-0319662IPR017927
DomainFAD_FR

NOS1 NOS3

2.02e-0319662PS51384
DomainRiboflavin_synthase-like_b-brl

NOS1 NOS3

2.02e-0319662IPR017938
DomainHis_PPase_superfam

PPIP5K1 PPIP5K2

2.24e-0320662IPR029033
Domain-

PPIP5K1 PPIP5K2

2.24e-03206623.40.50.1240
Domain-

CD1B NFKB1 NFKB2 HAPLN4 KIR3DL2 PKHD1L1 PLXNB3 SEMA3E

2.26e-036636682.60.40.10
DomainFGF

FGF2 FGF9

2.71e-0322662SM00442
DomainFGF

FGF2 FGF9

2.71e-0322662PF00167
DomainHBGF_FGF

FGF2 FGF9

2.71e-0322662PS00247
DomainFibroblast_GF_fam

FGF2 FGF9

2.71e-0322662IPR002209
DomainIL-1_fam/FGF_fam

FGF2 FGF9

2.97e-0323662IPR028142
Domainzf-CCHC

RTL3 ZCCHC3

2.97e-0323662PF00098
DomainIg-like_fold

CD1B NFKB1 NFKB2 HAPLN4 KIR3DL2 PKHD1L1 PLXNB3 SEMA3E

3.33e-03706668IPR013783
Domain-

RTL3 ZCCHC3

3.78e-03266624.10.60.10
DomainDEATH

NFKB1 NFKB2

4.08e-0327662SM00005
DomainSema

PLXNB3 SEMA3E

5.35e-0331662SM00630
DomainSemap_dom

PLXNB3 SEMA3E

5.35e-0331662IPR001627
DomainSema

PLXNB3 SEMA3E

5.35e-0331662PF01403
DomainSEMA

PLXNB3 SEMA3E

5.35e-0331662PS51004
DomainDeath

NFKB1 NFKB2

6.05e-0333662PF00531
DomainZF_CCHC

RTL3 ZCCHC3

6.79e-0335662PS50158
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

ITGA1 PLXNB3 SEMA3E

3.04e-0519463M10959
PathwayPID_IL12_2PATHWAY

EOMES SPHK2 NFKB1 NFKB2

4.82e-0562464M54
PathwayWP_RAS_AND_BRADYKININ_PATHWAYS_IN_COVID19

NFKB1 NOS1 NOS3

1.12e-0429463M40051
PathwayREACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION

NFKB1 NFKB2

2.16e-047462MM14930
PathwayREACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID

NFKB1 NFKB2

2.16e-047462M27463
PathwayREACTOME_DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION

NFKB1 NFKB2

2.16e-047462M27227
PathwayWP_EFFECTS_OF_NITRIC_OXIDE

NOS1 NOS3

2.88e-048462M39677
PathwayKEGG_AMINOACYL_TRNA_BIOSYNTHESIS

MARS2 NARS1 NARS2

3.18e-0441463M14691
PathwayREACTOME_TRNA_AMINOACYLATION

MARS2 NARS1 NARS2

3.41e-0442463M456
PathwayREACTOME_INTERLEUKIN_1_PROCESSING

NFKB1 NFKB2

3.70e-049462M27383
PathwayREACTOME_INTERLEUKIN_1_PROCESSING

NFKB1 NFKB2

3.70e-049462MM15129
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

NFKB1 NFKB2 KMT2A

4.47e-0446463MM14933
PathwayREACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL

PPIP5K1 PPIP5K2

4.61e-0410462MM14709
PathwayREACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL

PPIP5K1 PPIP5K2

4.61e-0410462M27051
PathwayWP_NOCGMPPKG_MEDIATED_NEUROPROTECTION

NFKB1 NOS1 NOS3

4.77e-0447463M39531
PathwayPID_ANGIOPOIETIN_RECEPTOR_PATHWAY

NFKB1 FGF2 NOS3

5.39e-0449463M92
PathwayREACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1

FGF2 FGF9

5.62e-0411462M675
PathwayWP_INCLUSION_BODY_MYOSITIS

NFKB1 NFKB2

5.62e-0411462M42545
PathwayREACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

6.73e-0412462MM14728
PathwayREACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE

NOS1 NOS3

7.94e-0413462MM15015
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

NFKB1 NFKB2

7.94e-0413462MM14616
PathwayWP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS

NOS1 NOS3

7.94e-0413462M39894
PathwayREACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

7.94e-0413462M1087
PathwayREACTOME_FGFR3_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

7.94e-0413462M27061
PathwayREACTOME_FGFR3_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

7.94e-0413462MM14723
PathwayREACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

7.94e-0413462MM14727
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

PLXNB3 SEMA3E

9.25e-0414462MM15047
PathwayREACTOME_FGFR1C_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

9.25e-0414462M27065
PathwayWP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS

SPHK2 NFKB1

9.25e-0414462M45553
PathwayWP_ECTODYSPLASIN_A_SIGNALING_IN_HAIR_FOLLICLE_DEVELOPMENT

NFKB1 NFKB2

9.25e-0414462MM15847
PathwayREACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION

NFKB1 NFKB2

9.25e-0414462MM15641
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4

FGF2 FGF9

1.06e-0315462M27509
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR4

FGF2 FGF9

1.06e-0315462MM15235
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

NFKB1 NFKB2 FGF2 NOS1

1.10e-03140464M42572
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

ITGA1 PLXNB3 SEMA3E

1.18e-0364463M7923
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR1

FGF2 FGF9

1.21e-0316462M48007
PathwayWP_QUERCETIN_AND_NFKB_AP1_INDUCED_APOPTOSIS

NFKB1 NOS1

1.21e-0316462M42567
PathwayREACTOME_THE_NLRP3_INFLAMMASOME

NFKB1 NFKB2

1.21e-0316462M1063
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR1

FGF2 FGF9

1.21e-0316462MM15233
PathwayBIOCARTA_GCR_PATHWAY

NFKB1 NOS3

1.37e-0317462M10066
PathwayREACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

1.37e-0317462MM17066
PathwayBIOCARTA_GCR_PATHWAY

NFKB1 NOS3

1.37e-0317462MM1372
PathwayREACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1

NFKB1 NFKB2

1.37e-0317462M583
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2

FGF2 FGF9

1.37e-0317462MM15234
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR3

FGF2 FGF9

1.37e-0317462MM15244
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

NFKB1 NFKB2 KMT2A

1.53e-0370463M27231
PathwayREACTOME_PHOSPHOLIPASE_C_MEDIATED_CASCADE_FGFR2

FGF2 FGF9

1.54e-0318462M27508
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR3

FGF2 FGF9

1.54e-0318462M27518
PathwayREACTOME_PI_3K_CASCADE_FGFR3

FGF2 FGF9

1.54e-0318462M27521
PathwayREACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

1.54e-0318462M1092
PathwayREACTOME_PI_3K_CASCADE_FGFR3

FGF2 FGF9

1.54e-0318462MM15247
PathwayREACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

1.54e-0318462MM14724
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RAMP1 NFKB1 NOS1 NOS3

1.56e-03154464MM15974
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

RAMP1 NFKB1 NOS1 NOS3

1.64e-03156464M39475
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

EOMES RPL24 KRT28 NTN3 NFKB1 FGF2 KMT2A FGF9 ITGA1 KRTAP13-1 PLXNB3 SEMA3E

1.69e-0314324612M509
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR4

FGF2 FGF9

1.72e-0319462MM15250
PathwayWP_ASPIRIN_AND_MIRNAS

NFKB1 NOS3

1.72e-0319462M48319
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

FGF2 FGF9

1.72e-0319462MM15245
PathwayREACTOME_FRS_MEDIATED_FGFR3_SIGNALING

FGF2 FGF9

1.91e-0320462M27519
PathwayREACTOME_PI_3K_CASCADE_FGFR4

FGF2 FGF9

1.91e-0320462M27525
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR4

FGF2 FGF9

1.91e-0320462M27524
PathwayREACTOME_PI_3K_CASCADE_FGFR4

FGF2 FGF9

1.91e-0320462MM15251
PathwayREACTOME_FGFR2_LIGAND_BINDING_AND_ACTIVATION

FGF2 FGF9

1.91e-0320462M27062
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR1

FGF2 FGF9

1.91e-0320462MM15237
PathwayREACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM

PANK4 NUDT8

1.91e-0320462M538
PathwayREACTOME_PI_3K_CASCADE_FGFR1

FGF2 FGF9

2.10e-0321462M27512
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR1

FGF2 FGF9

2.10e-0321462M27511
PathwayWP_EBV_LMP1_SIGNALING

NFKB1 NFKB2

2.10e-0321462MM15923
PathwayWP_BURN_WOUND_HEALING

FGF2 NOS3

2.10e-0321462MM15978
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

NFKB1 NFKB2

2.10e-0321462M26978
PathwayREACTOME_INFLAMMASOMES

NFKB1 NFKB2

2.10e-0321462M1072
PathwayREACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION

MARS2 NARS2

2.10e-0321462M15096
PathwayREACTOME_PI_3K_CASCADE_FGFR1

FGF2 FGF9

2.10e-0321462MM15238
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

FGF2 FGF9

2.10e-0321462MM15248
PathwayREACTOME_SHC_MEDIATED_CASCADE_FGFR2

FGF2 FGF9

2.10e-0321462MM15242
PathwayREACTOME_FRS_MEDIATED_FGFR4_SIGNALING

FGF2 FGF9

2.31e-0322462M27522
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

FGF2 FGF9

2.31e-0322462MM15239
PathwayREACTOME_PI_3K_CASCADE_FGFR2

FGF2 FGF9

2.31e-0322462MM15240
PathwayREACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE

NOS1 NOS3

2.31e-0322462M915
PathwayREACTOME_PI_3K_CASCADE_FGFR2

FGF2 FGF9

2.52e-0323462M27514
PathwayREACTOME_FRS_MEDIATED_FGFR1_SIGNALING

FGF2 FGF9

2.52e-0323462M27513
PathwayWP_EBSTEINBARR_VIRUS_LMP1_SIGNALING

NFKB1 NFKB2

2.52e-0323462M39410
PathwayWP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS

NFKB1 NFKB2

2.52e-0323462M39862
PathwayWP_SILDENAFIL_TREATMENT

NOS1 NOS3

2.52e-0323462M46455
PathwayWP_LDL_INFLUENCE_ON_CD14_AND_TLR4

NFKB1 NFKB2

2.52e-0323462M45556
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

FGF2 FGF9

2.52e-0323462MM15243
PathwayWP_ANGIOGENESIS

FGF2 NOS3

2.75e-0324462M39556
PathwayWP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS

NOS1 NOS3

2.75e-0324462M39850
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3

FGF2 FGF9

2.75e-0324462MM15246
PathwayREACTOME_FRS_MEDIATED_FGFR2_SIGNALING

FGF2 FGF9

2.98e-0325462M27517
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3

FGF2 FGF9

2.98e-0325462M27520
PathwayREACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION

NFKB1 NFKB2

2.98e-0325462M940
PathwayREACTOME_PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION

NFKB1 NFKB2

3.22e-0326462M29838
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4

FGF2 FGF9

3.22e-0326462MM15249
PathwayWP_CORTICOTROPINRELEASING_HORMONE_SIGNALING

CYP11B1 NFKB1 NOS3

3.33e-0392463M39441
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR4

FGF2 FGF9

3.47e-0327462M27523
PathwayREACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2

FGF2 FGF9

3.73e-0328462MM15241
PathwayWP_NEURAL_CREST_DIFFERENTIATION

NFKB1 NFKB2 FGF2

3.87e-0397463MM15926
PathwayKEGG_PATHWAYS_IN_CANCER

NFKB1 NFKB2 WNT8B FGF2 FGF9

3.99e-03325465M12868
PathwayREACTOME_NEGATIVE_REGULATION_OF_FGFR3_SIGNALING

FGF2 FGF9

4.00e-0329462M27528
Pubmed

Nitric oxide inhibits HIV tat-induced NF-kappaB activation.

NFKB1 NFKB2 NOS3

3.63e-07866310393859
Pubmed

CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.

CADPS CADPS2

3.55e-06266218177725
Pubmed

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.

KMT2A GAS7

3.55e-06266210706619
Pubmed

Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP.

NFKB1 NOS1

3.55e-06266218508038
Pubmed

Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.

NOS1 NOS3

3.55e-06266215350652
Pubmed

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

NOS1 NOS3

3.55e-06266224643800
Pubmed

Quantitative dissection and modeling of the NF-κB p100-p105 module reveals interdependent precursor proteolysis.

NFKB1 NFKB2

3.55e-06266225482563
Pubmed

Intron 4 polymorphism of the endothelial nitric oxide synthase gene is associated with the development of lupus nephritis.

NOS1 NOS3

3.55e-06266215119548
Pubmed

Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.

NOS1 NOS3

3.55e-06266221825026
Pubmed

Chronic NOS inhibition actuates endothelial-mesenchymal transformation.

NOS1 NOS3

3.55e-06266216963618
Pubmed

Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

PPIP5K1 PPIP5K2

3.55e-06266218981179
Pubmed

Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.

NOS1 NOS3

3.55e-0626628667023
Pubmed

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.

NOS1 NOS3

3.55e-06266211015578
Pubmed

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.

NFKB1 NFKB2

3.55e-06266228368397
Pubmed

NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives.

NFKB1 NOS3

3.55e-06266217644577
Pubmed

Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice.

NOS1 NOS3

3.55e-06266215961532
Pubmed

Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia.

NOS1 NOS3

3.55e-06266214526232
Pubmed

Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption.

NFKB1 NFKB2

3.55e-06266212568403
Pubmed

Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children.

NOS1 NOS3

3.55e-06266216238787
Pubmed

Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism.

NOS1 NOS3

3.55e-06266224076963
Pubmed

Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.55e-06266211027405
Pubmed

Neuronal nitric oxide synthase plays a key role in CNS demyelination.

NOS1 NOS3

3.55e-06266217151270
Pubmed

Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.

NOS1 NOS3

3.55e-06266218305236
Pubmed

Regulation of renin gene expression in kidneys of eNOS- and nNOS-deficient mice.

NOS1 NOS3

3.55e-06266210764216
Pubmed

Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.

NOS1 NOS3

3.55e-06266218342297
Pubmed

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity.

NOS1 NOS3

3.55e-0626627488039
Pubmed

The NOS3 G894T (Glu298Asp) polymorphism is a risk factor for frontotemporal lobar degeneration.

NOS1 NOS3

3.55e-06266219087148
Pubmed

Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.

NOS1 NOS3

3.55e-0626629932431
Pubmed

Rapid cerebral ischemic preconditioning in mice deficient in endothelial and neuronal nitric oxide synthases.

NOS1 NOS3

3.55e-06266212677017
Pubmed

Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.

NOS1 NOS3

3.55e-06266221813683
Pubmed

Expression, localization, and regulation of NOS in human mast cell lines: effects on leukotriene production.

NOS1 NOS3

3.55e-06266215044250
Pubmed

NF-kappaB to the rescue: RELs, apoptosis and cellular transformation.

NFKB1 NFKB2

3.55e-06266210354583
Pubmed

Cutaneous neuronal nitric oxide is specifically decreased in postural tachycardia syndrome.

NOS1 NOS3

3.55e-06266217660395
Pubmed

Endothelial Nitric Oxide Synthase Is Present in Dendritic Spines of Neurons in Primary Cultures.

NOS1 NOS3

3.55e-06266228725180
Pubmed

Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase.

NOS1 NOS3

3.55e-06266210534440
Pubmed

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.

RNF123 NFKB1

3.55e-06266228389511
Pubmed

Analysis of nitric oxide synthase gene polymorphisms in neonatal respiratory distress syndrome among the Chinese Han population.

NOS1 NOS3

3.55e-06266224602444
Pubmed

Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.

NOS1 NOS3

3.55e-06266212788381
Pubmed

CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.

CADPS CADPS2

3.55e-06266218022372
Pubmed

Angiotensin II response in afferent arterioles of mice lacking either the endothelial or neuronal isoform of nitric oxide synthase.

NOS1 NOS3

3.55e-06266217959704
Pubmed

Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.

NOS1 NOS3

3.55e-0626629692709
Pubmed

Myocardial and lymphocytic expression of eNOS and nNOS before and after heart transplantation: relationship to clinical status.

NOS1 NOS3

3.55e-06266223770231
Pubmed

Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis.

NOS1 NOS3

3.55e-06266215287858
Pubmed

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

NOS1 NOS3

3.55e-06266210905473
Pubmed

Nitric oxide synthase gene polymorphisms in children with minimal change nephrotic syndrome.

NOS1 NOS3

3.55e-06266219371282
Pubmed

Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.

NFKB1 NFKB2

3.55e-06266218250170
Pubmed

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.

NOS1 NOS3

3.55e-06266211907582
Pubmed

Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

NOS1 NOS3

3.55e-06266220624383
Pubmed

New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.

NFKB1 NFKB2

3.55e-0626629895331
Pubmed

Neuronal NOS-cGMP-dependent ACh-induced relaxation in pial arterioles of endothelial NOS knockout mice.

NOS1 NOS3

3.55e-0626629486242
Pubmed

Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.55e-06266210727738
Pubmed

Developmental changes in the response of murine cerebellar granule cells to nitric oxide.

NOS1 NOS3

3.55e-06266218406496
Pubmed

Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion.

NOS1 NOS3

3.55e-06266218971208
Pubmed

Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?

NOS1 NOS3

3.55e-06266212908999
Pubmed

Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.

NOS1 NOS3

3.55e-06266231259693
Pubmed

Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles.

NOS1 NOS3

3.55e-06266211161004
Pubmed

CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.

CADPS CADPS2

3.55e-06266228883501
Pubmed

How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?

NFKB1 NFKB2

3.55e-06266236706462
Pubmed

Neuronal and endothelial nitric oxide synthase gene knockout mice.

NOS1 NOS3

3.55e-06266210559836
Pubmed

A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.

RNF123 NFKB1

3.55e-06266234873064
Pubmed

Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential.

FGF2 FGF9

3.55e-06266215780951
Pubmed

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice.

NOS1 NOS3

3.55e-06266210027769
Pubmed

Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.

NOS1 NOS3

3.55e-06266229110178
Pubmed

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.

PPIP5K1 PPIP5K2

3.55e-06266228126903
Pubmed

Carvedilol induces biased β1 adrenergic receptor-nitric oxide synthase 3-cyclic guanylyl monophosphate signalling to promote cardiac contractility.

NOS1 NOS3

3.55e-06266232956449
Pubmed

Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.

NOS1 NOS3

3.55e-06266211904450
Pubmed

Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.

NOS1 NOS3

3.55e-06266212381527
Pubmed

Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure.

NOS1 NOS3

3.55e-06266215033959
Pubmed

Liver-Resident NK Cells: The Human Factor.

EOMES ITGA1

3.55e-06266228318877
Pubmed

Infarct size and nitric oxide synthase in murine myocardium.

NOS1 NOS3

3.55e-06266210652188
Pubmed

Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice.

NOS1 NOS3

3.55e-06266210982771
Pubmed

Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.

CADPS CADPS2

3.55e-06266220855507
Pubmed

Related subunits of NF-kappa B map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.

NFKB1 NFKB2

3.55e-0626621612589
Pubmed

Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase.

FGF2 NOS3

3.55e-06266210036253
Pubmed

The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas.

NFKB1 NFKB2

3.55e-06266216751281
Pubmed

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

NOS1 NOS3

3.55e-06266226152695
Pubmed

Alternatively spliced neuronal nitric oxide synthase mediates penile erection.

NOS1 NOS3

3.55e-06266216488973
Pubmed

The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.

NOS1 NOS3

3.55e-06266219095954
Pubmed

CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.

CADPS CADPS2

3.55e-06266218495893
Pubmed

Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.

NOS1 NOS3

3.55e-06266218048451
Pubmed

Monitoring a nuclear factor-κB signature of drug resistance in multiple myeloma.

NFKB1 NFKB2

3.55e-06266221846842
Pubmed

Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study.

NOS1 NOS3

3.55e-06266212802542
Pubmed

Oxygen seizure latency and peroxynitrite formation in mice lacking neuronal or endothelial nitric oxide synthases.

NOS1 NOS3

3.55e-06266212781920
Pubmed

Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS.

NOS1 NOS3

3.55e-0626627518615
Pubmed

Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90.

NOS1 NOS3

3.55e-06266217970747
Pubmed

Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms.

NOS1 NOS3

3.55e-06266217351927
Pubmed

Establishment of patterned thalamocortical connections does not require nitric oxide synthase.

NOS1 NOS3

3.55e-0626629786989
Pubmed

Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release.

NOS1 NOS3

3.55e-06266218046021
Pubmed

Nitric oxide synthase gene polymorphisms in children with primary nocturnal enuresis: a preliminary study.

NOS1 NOS3

3.55e-06266217365914
Pubmed

NOS-I and -III gene variants are differentially associated with facets of suicidal behavior and aggression-related traits.

NOS1 NOS3

3.55e-06266217579350
Pubmed

Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation.

NOS1 NOS3

3.55e-06266216545353
Pubmed

Neuronal nitric oxide synthase in epidermis is involved in cutaneous circulatory response to mechanical stimulation.

NOS1 NOS3

3.55e-06266219940861
Pubmed

Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart.

NOS1 NOS3

3.55e-06266222058155
Pubmed

Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF.

NOS1 NOS3

3.55e-06266217459722
Pubmed

NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.

NFKB1 NFKB2

3.55e-06266217109470
Pubmed

Requirement for NF-kappaB in osteoclast and B-cell development.

NFKB1 NFKB2

3.55e-0626629407039
Pubmed

Structures of human constitutive nitric oxide synthases.

NOS1 NOS3

3.55e-06266225286850
Pubmed

Protective role of peroxisome proliferator-activated receptor-β/δ against pulmonary oxygen toxicity mediated through changes in NOS expression levels.

NOS1 NOS3

3.55e-06266224624894
Pubmed

Characterization of a nitric oxide synthase from the plant kingdom: NO generation from the green alga Ostreococcus tauri is light irradiance and growth phase dependent.

NOS1 NOS3

3.55e-06266221119059
Pubmed

Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase.

NOS1 NOS3

3.55e-0626628978606
Cytoband10q24

NFKB2 WNT8B

1.17e-033566210q24
GeneFamilyAnkyrin repeat domain containing|NF-kappa B complex subunits

NFKB1 NFKB2

7.46e-0555021254
GeneFamilyAminoacyl tRNA synthetases, Class II

NARS1 NARS2

1.24e-0319502132
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

RTL3 ZCCHC3

2.16e-032550274
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#1

RAMP1 GPATCH3 GAS7 EFCC1 NUDT8 KIR3DL2 GPR179

2.69e-05291647Facebase_RNAseq_e10.5_Medial Nasal Eminence_500_K1
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SASH1 ADAMTS20 EFCC1 ITGA1 PKHD1L1

7.30e-06181665e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

SASH1 CADPS2 PKHD1L1 NOS1 NOS3

8.78e-06188665d582b76fc2faac526c9bf97503041129e1a6a211
ToppCelldroplet-Heart-HEART-1m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT28 ADAMTS20 GAS7 PLXNB3 DNAH11

9.01e-06189665a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT28 ADAMTS20 GAS7 PLXNB3 DNAH11

9.01e-061896654e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

SASH1 ITGA1 CADPS2 PKHD1L1 NOS3

9.01e-0618966575c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 CADPS ADAMTS20 NOS1 ALK

1.02e-05194665e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellCOVID-19-Lymphoid-CD8_T_cells|Lymphoid / Condition, Lineage and Cell class

EOMES APMAP GAS7 ITGA1 KIR3DL2

1.05e-05195665d4c70a462b98963e78f4e2659574bc350f8ffe1a
ToppCellnormal_Lymph_Node-T/NK_cells-NK|normal_Lymph_Node / Location, Cell class and cell subclass

EOMES RAMP1 APMAP GAS7 KIR3DL2

1.07e-0519666500ab4a1547752d419aa720b39b94a4ab2ede963a
ToppCellnormal_Lymph_Node-T/NK_cells-NK|T/NK_cells / Location, Cell class and cell subclass

EOMES RAMP1 APMAP GAS7 KIR3DL2

1.13e-0519866575e94298bf03d755fef46df685437d0d29fdbca9
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

SASH1 ADAMTS20 ITGA1 NOS1 ALK

1.18e-05200665107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellfacs-Heart-RV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP1 MYO1A FGF9 DMWD

4.84e-0513566499e7ac9b1139fe4ff036f6f048a8f1cc514c1fb9
ToppCellfacs-Heart-RV-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAMP1 MYO1A FGF9 DMWD

4.84e-051356641fe684ed5913ae757ad6befbbe12d1bee481dd12
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FGF9 NOS1 ALK SEMA3E

7.67e-05152664fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCellICU-SEP-Lymphocyte-T_NK-gdT|ICU-SEP / Disease, Lineage and Cell Type

EOMES APMAP KIR3DL2 NOS1

9.35e-051606640a14b1fed54a09c0caf263662b5bd426466c7189
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FGF9 NOS1 ALK SEMA3E

1.03e-0416466408819970174a3eb4eee8e1e675075828665b845e
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-|GI_small-bowel / Manually curated celltypes from each tissue

EOMES RAMP1 GJD3 GAS7

1.03e-0416466436e64e4f717dd59b352c20ff9742ca1e232342bb
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-mature_NK_T_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EOMES RAMP1 RTL3 APMAP

1.08e-0416666461e4b2d2db093e64f7354b534aa8571803a3bd44
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CADPS NFKB1 NFKB2 C1QTNF4

1.18e-04170664be2a34c70665d8d11332b1a70eda03d77cb7f7dd
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EOMES APMAP ITGA1 KIR3DL2

1.21e-04171664adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.24e-0417266486f52f486d67217fc1b8443ab362c975df2974a4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.24e-04172664fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.24e-04172664e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.24e-04172664e3a8891694343b6b01e80a200ae338d24797e417
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES APMAP EFCC1 KIR3DL2

1.32e-041756648fb8c4b9e2d9b7d737f59cd9bd3dc2bca5a8dfc4
ToppCellmetastatic_Brain-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

CD1B ZDHHC18 PANK4 DNAH11

1.35e-041766649c1f255de3082b3da4bef2a9bdff710cfd48261f
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GJD3 EFCC1 PKHD1L1 NOS3

1.35e-04176664460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SASH1 EFCC1 PKHD1L1 PLXNB3

1.38e-04177664b1775e05c28883a15c56628028770bc59d3233fb
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGF9 EFCC1 GPR179 SEMA3E

1.44e-041796647c8a2fa1326c73dc9e774df645b572864fd97133
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_bright-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

EOMES RAMP1 APMAP ALK

1.50e-041816649c4f9abb9335da2b07644bca8faff1baa1bb9f5b
ToppCell3'_v3-Lung-Myeloid_Dendritic-migDC|Lung / Manually curated celltypes from each tissue

CD1B RAMP1 NFKB1 NOS1

1.54e-04182664cd6e3a9f4eb4fe73b28da61d1d35c64fd9ffa892
ToppCellGlobus_pallidus-Neuronal-Inhibitory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CADPS HAPLN4 FGF9 ALK

1.54e-0418266404ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_KLHL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 ADAMTS20 ITGA1 ALK

1.57e-04183664439b1d1373b7cc73d65f3b59037a6def7cf8f4ba
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

SASH1 PKHD1L1 NOS1 NOS3

1.57e-0418366446be9f96755c7b65aeac061d95d15abeb6466034
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 GAS7 PLXNB3 SEMA3E

1.60e-04184664da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

SASH1 EFCC1 ITGA1 PKHD1L1

1.63e-041856644a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

SASH1 EFCC1 ITGA1 PKHD1L1

1.63e-0418566436ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SASH1 ADAMTS20 EFCC1 PKHD1L1

1.67e-0418666420340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCellnormal_Lung-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

CD1B RAMP1 FGF9 NOS1

1.67e-0418666400ad1239b952119b3fd2e6af8f034cba3488f9c1
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

SASH1 CADPS2 PKHD1L1 NOS3

1.70e-041876647876dcb4800c2e54874df3d933efb79307a64a97
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

SASH1 PKHD1L1 NOS1 NOS3

1.70e-041876642d20193a6cacdfa4877457c97b0077408942186c
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 GAS7 PLXNB3 SEMA3E

1.70e-04187664a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 GAS7 PLXNB3 SEMA3E

1.70e-04187664f2af79a20438108c814a73f9e24cd986d537237f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EOMES CADPS HAPLN4 C1QTNF4

1.74e-041886641efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellNS-critical-d_16-33-Lymphoid-CTL|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EOMES APMAP ITGA1 KIR3DL2

1.77e-041896648a02c40bfc92cee37c4dee7c7bf98ab826f64a14
ToppCell10x_3'_v3-spleen_(10x_3'_v3)|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

EOMES ZDHHC18 DGAT2 NFKB2

1.77e-041896640fe8901e10c619c93b7788792da1706a32102c6e
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

SASH1 ITGA1 CADPS2 PKHD1L1

1.77e-04189664c81787a8c662db5d7814c583dd64562857629e81
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HAPLN4 C1QTNF4 CADPS2 NOS1

1.77e-04189664f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SASH1 GAS7 EFCC1 PKHD1L1

1.81e-04190664876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD1B RAMP1 NFKB1 NFKB2

1.81e-041906642ff4b50b864a35f22c558d7d585cd2b54612b50c
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SASH1 CADPS2 PKHD1L1 NOS3

1.81e-041906641caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAMP1 CADPS ITGA1 SEMA3E

1.81e-04190664562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAMP1 CADPS ITGA1 SEMA3E

1.81e-04190664f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SASH1 GAS7 EFCC1 PKHD1L1

1.81e-04190664be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD1B RAMP1 NFKB1 NFKB2

1.81e-041906645175bf022d55a52988014abe7cece326a8406a38
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SASH1 GAS7 EFCC1 PKHD1L1

1.81e-0419066409a8855901c3c9332dbaab3e40166485b696d0f1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.81e-04190664600b9674197f743dea1d19d3df0fc993b6e6aa25
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD1B RAMP1 NFKB1 NFKB2

1.81e-0419066429e60b9b1c86b44550619c01306b8b1bb2e340dc
ToppCell3'_v3-bone_marrow|World / Manually curated celltypes from each tissue

RAMP1 APMAP GAS7 EMP3

1.85e-041916647b759831f1b1c8575c31f67d0d9eb11c6a833cf3
ToppCellIPF-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

RAMP1 APMAP GAS7 KIR3DL2

1.85e-04191664f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

ITGA1 CADPS2 PKHD1L1 NOS3

1.85e-04191664c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 ADAMTS20 ITGA1 ALK

1.85e-041916649c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCellcritical-Lymphoid-CTL|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EOMES KMT2A ITGA1 KIR3DL2

1.88e-041926648c83050c1578d43ca0398ff920f30ea63f092a83
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CD1B RAMP1 NFKB1 NFKB2

1.88e-041926642c69f3f388b69fb1c1968c923cdbab90658883dd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPR20 CADPS ITGA1 DNAH11

1.88e-0419266424e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCellnormal_Pleural_Fluid-T/NK_cells-NK|normal_Pleural_Fluid / Location, Cell class and cell subclass

EOMES RAMP1 APMAP KIR3DL2

1.88e-0419266459dd4f5ae9f1cca78adf60b71661092ef09e6641
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD1B RAMP1 NFKB1 NFKB2

1.88e-04192664d5a7b546ebfb2e757dd9c64cb1b651f6ed0e0fc7
ToppCellwk_08-11-Epithelial-PNS-KCNIP4+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RAMP1 NOS1 ALK GPR179

1.88e-0419266453642c88891f4e4e14b1740c5ced759b7d8b3572
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.88e-04192664c5f77c2103841505d13e09173549811312ef2f01
ToppCellcontrol-NK|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

EOMES RAMP1 APMAP KIR3DL2

1.88e-04192664cec6ab5793953072e6b0fee370551224947dd877
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

ITGA1 CADPS2 PKHD1L1 NOS3

1.88e-041926648a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.88e-04192664e981162f387a31111c0ae8355dbe9db5785c4838
ToppCellNS-critical-d_07-13-Lymphoid-CTL|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EOMES KMT2A ITGA1 KIR3DL2

1.88e-04192664e7e5ba94ee8fd3c04bb4c358c86d0227c563e9dc
ToppCellfacs-Brain_Non-Myeloid-Striatum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DGAT2 GAS7 EFCC1 DMWD

1.92e-04193664d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

SASH1 ITGA1 CADPS2 PKHD1L1

1.92e-0419366401c2df9206f1527c578e808978e58196c35e72f5
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 ADAMTS20 ITGA1 NOS1

1.92e-04193664010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.92e-0419366454604c2c5dce2ff6f3ec7ca82b595b09b8cdafe8
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SASH1 PKHD1L1 NOS1 NOS3

1.92e-041936649ba688b35a9ead5d04691b3f3f15484f02dbbd0d
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

SASH1 ITGA1 CADPS2 PKHD1L1

1.92e-041936642531266bc57339d4e2b22a88817008e32b8c1598
ToppCellInt-URO-Lymphocyte-T_NK-NK|Int-URO / Disease, Lineage and Cell Type

EOMES RAMP1 APMAP KIR3DL2

1.92e-041936645c7942f630fc69374df34ee3602ad973b6ced17a
ToppCellICU-SEP-Lymphocyte-T_NK-NK|ICU-SEP / Disease, Lineage and Cell Type

EOMES RAMP1 APMAP KIR3DL2

1.92e-04193664f110f86db305e41639087f5b1a2dff103c07adf0
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SASH1 ITGA1 NOS1 ALK

1.92e-041936645581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellNS-moderate-d_16-33-Lymphoid-CTL|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EOMES KMT2A ITGA1 EMP3

1.96e-041946646b2bb3dd11fd53fa9ab4d66c18b0714f96f99288
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD1B RAMP1 NFKB1 NFKB2

1.96e-0419466436f8ae4f2b3bf802f6ff0e9fc79e7f170f96ae8b
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

SASH1 CADPS2 PKHD1L1 NOS3

1.96e-04194664b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellControl-Myeloid-Migratory_DC|Control / Condition, Lineage and Cell class

CD1B RAMP1 NFKB1 NFKB2

1.96e-04194664374076e60dcee83eb1814aa6b55b77668909f40b
ToppCellICU-NoSEP-Lymphocyte-T_NK-NK|ICU-NoSEP / Disease, Lineage and Cell Type

EOMES RAMP1 APMAP KIR3DL2

1.96e-04194664090edfc884655e5ab38b027c6e1a5aa809ebb19d
ToppCellLeuk-UTI-Lymphocyte-T_NK-NK|Leuk-UTI / Disease, Lineage and Cell Type

EOMES RAMP1 APMAP KIR3DL2

1.96e-0419466436afc4e48d267be3b8aa1e33fad043bcd54c6bc5
ToppCelldistal-1-Hematologic-Myeloid_Dendritic_Type_1|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CD1B ZDHHC18 RAMP1 NFKB1

1.96e-0419466485a4be291c25ad1fb14199b87d822cf47d748fc0
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

1.96e-0419466452e09b14159b609af00264a8f38accf37ba8f464
ToppCell10x5'-Lung-Lymphocytic_NK-NK_CD16|Lung / Manually curated celltypes from each tissue

EOMES RAMP1 APMAP KIR3DL2

2.00e-04195664e91e7f89163c615b706f3297b641b1e4c966f5e6
ToppCellBLOOD--(1)_T_cell-(1)_EM_CTLs|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

EOMES APMAP EMP3 KIR3DL2

2.00e-041956647df67ad5c62235474ee56ea07a957253d45f066b
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_NK|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

EOMES RAMP1 APMAP KIR3DL2

2.00e-04195664ed41e709523cc3b86b1090d4fc0938ed47cb1fc9
ToppCellControl-Myeloid-Migratory_DC|Myeloid / Condition, Lineage and Cell class

CD1B RAMP1 NFKB1 NFKB2

2.00e-041956649f1ad04abc6a6c5e093ea24b60732871b1fad5a4
ToppCellT_cells-GZMK+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

EOMES APMAP GAS7 ITGA1

2.00e-04195664003ea7ddec6c1c98d2f6470bb51ebd97450eb936
ToppCell3'_v3-blood-Lymphocytic_NK|blood / Manually curated celltypes from each tissue

RAMP1 APMAP NFKB1 NFKB2

2.00e-04195664731a454e45c7b610e0140312bcabaea711dcc766
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

2.00e-0419566498b02beafe1d418442e41f85cbf0c7b194fe5957
ToppCellsystemic_lupus_erythematosus-managed-Lymphocytic_NK|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

EOMES RAMP1 APMAP KIR3DL2

2.00e-04195664acc603dc94ac6518adb0dffb43305b380ec75b52
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EOMES RAMP1 APMAP KIR3DL2

2.00e-041956649ecae6c26a0d0607d101ccf1c38f0b23c5a256a8
ToppCell10x5'-Lung-Lymphocytic_NK|Lung / Manually curated celltypes from each tissue

EOMES RAMP1 APMAP KIR3DL2

2.00e-04195664a5a10ef9254c266316e5591bec19e159cc3caead
ToppCellnormal-na-Lymphocytic_NK|normal / PBMC cell types (v2) per disease, treatment status, and sex

EOMES RAMP1 APMAP KIR3DL2

2.00e-04195664cebe79c42af5910353ba9ad7d0edb01982f772a3
Drugramiprilat

THOP1 NFKB1 NFKB2 NOS1 NOS3

5.46e-0755665CID005464096
Drugtriflusal

NFKB1 NFKB2 NOS1 NOS3

7.78e-0725664CID000009458
DrugL-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide

NOS1 NOS3

8.28e-062662DB01821
DrugS-Ethyl-N-Phenyl-Isothiourea

NOS1 NOS3

8.28e-062662DB03707
DrugL-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide

NOS1 NOS3

8.28e-062662DB02077
DrugN-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine

NOS1 NOS3

8.28e-062662DB02027
DrugN-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE

NOS1 NOS3

8.28e-062662DB08018
DrugN-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine

NOS1 NOS3

8.28e-062662DB08019
DrugNitroarginine

NOS1 NOS3

8.28e-062662DB04223
DrugS-methylisothiourea

FGF2 NOS1 NOS3

1.54e-0517663CID000005142
DrugASA404

NFKB1 NFKB2 NOS1 NOS3

1.69e-0553664CID000123964
Drugangiotensin

THOP1 CYP11B1 NFKB1 NFKB2 FGF2 NOS1 NOS3

1.73e-05282667CID003083715
DrugN-(3-(Aminomethyl)Benzyl)Acetamidine

NOS1 NOS3

2.48e-053662DB02044
Drug3-Bromo-7-Nitroindazole

NOS1 NOS3

2.48e-053662DB01997
DrugSelara

NFKB1 NFKB2 FGF2 NOS1 NOS3

3.15e-05125665CID000150310
Drugphenytoin

EOMES NFKB1 NFKB2 DMWD NOS1 NOS3

4.15e-05219666CID000001775
DrugTiron

EOMES NFKB1 NFKB2 NOS3

4.83e-0569664CID000009001
Drug(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin

NOS1 NOS3

4.95e-054662DB02692
DrugAC1L9HIO

NOS1 NOS3

4.95e-054662CID000445158
DrugN-Omega-Hydroxy-L-Arginine

NOS1 NOS3

4.95e-054662DB03144
Drugpanepoxydone

NFKB1 NFKB2 NOS3

5.11e-0525663CID000161704
DrugAC1O3R20

CYP11B1 NFKB1 NFKB2

7.24e-0528663CID006335051
DrugS-nitrosoacetylcysteine

NFKB1 NOS1 NOS3

8.05e-0529663CID000122058
DrugNSC294601

NFKB1 NFKB2

8.23e-055662CID000325606
DrugAC1MVXUL

NFKB1 NFKB2

8.23e-055662CID003715266
DrugAC1MNA05

NFKB1 NFKB2 GAS7

9.87e-0531663CID003274883
Druggoniothalamin

NFKB1 NOS1 NOS3

1.09e-0432663ctd:C103280
DrugL-Asparagine

NARS1 NARS2

1.23e-046662DB00174
DrugNapNa

NOS1 NOS3

1.23e-046662CID000128726
DrugN-nitroso-L-arginine

NOS1 NOS3

1.23e-046662CID000127762
Drug1-hexacosanol

NOS1 NOS3

1.23e-046662ctd:C051942
DrugAC1L1EDT

FGF2 NOS1 NOS3

1.31e-0434663CID000002751
DrugN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide

CYP11B1 NFKB1 FGF2 NOS1 NOS3

1.47e-04173665ctd:C063509
Drugtrinitrobenzene

NFKB1 NFKB2 NOS1 NOS3

1.49e-0492664CID000007434
DrugNSC-6354

NFKB1 NFKB2 NOS1 NOS3

1.49e-0492664CID000221534
DrugAC1NLRUC

NOS1 NOS3

1.72e-047662CID004988604
DrugCortodoxone

CYP11B1 NFKB1

1.72e-047662ctd:D003350
Drugdaunorubicin semiquinone

NFKB1 NFKB2 EMP3 DMWD NOS1 NOS3

1.77e-04285666CID000002958
Drugdiethyldithiocarbamate

NFKB1 NFKB2 NOS1 NOS3

2.13e-04101664CID000008987
Drug5H-purin-2-amine

NFKB1 NFKB2 KIR3DL2 NOS3

2.21e-04102664CID000409844
Drugudenafil

NOS1 NOS3

2.29e-048662ctd:C419664
Drug4a-d

NARS1 NARS2

2.29e-048662CID006852126
DrugZ-Ile-Glu(O-t-butyl)-Ala-Leucinal

NFKB1 NFKB2 FGF2

2.29e-0441663CID009960660
Drugcalphostin C

NFKB1 FGF2 NOS3

2.29e-0441663ctd:C058819
DrugU0126

SPHK2 DGAT2 NFKB1 NFKB2 FGF2 NOS1 NOS3

2.43e-04430667CID000005637
Drugalprazolam

EOMES CYP11B1 NFKB1 NFKB2 CYP26C1

2.44e-04193665CID000002118
DiseaseIntestinal Perforation

NOS1 NOS3

1.30e-053622C0021845
DiseaseCleft upper lip

FGF2 FGF9 NOS3

7.65e-0539623C0008924
DiseaseCleft palate, isolated

FGF2 FGF9 NOS3

9.57e-0542623C1837218
DiseaseCarcinoma, Granular Cell

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0205644
DiseaseAdenocarcinoma, Tubular

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0205645
DiseaseAdenocarcinoma, Oxyphilic

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0205642
DiseaseCarcinoma, Cribriform

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0205643
DiseaseAdenocarcinoma, Basal Cell

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0205641
DiseaseAdenocarcinoma

NFKB1 KMT2A FGF9 NOS3

1.06e-04116624C0001418
Diseasediabetic retinopathy (biomarker_via_orthology)

FGF2 NOS1 NOS3

1.18e-0445623DOID:8947 (biomarker_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

HAPLN4 ITGA1 DMWD DNAH11

1.21e-04120624EFO_0004611, EFO_0004639
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

NFKB1 NFKB2

1.55e-049622DOID:0050340 (implicated_via_orthology)
DiseaseImmunoglobulin Deficiency, Late-Onset

NFKB1 NFKB2

2.36e-0411622C2936665
DiseaseAcquired Hypogammaglobulinemia

NFKB1 NFKB2

2.36e-0411622C2936664
Diseasechronic kidney disease, Proteinuria

KMT2A GAS7

2.36e-0411622EFO_0003884, HP_0000093
DiseaseCommon variable immunodeficiency

NFKB1 NFKB2

3.34e-0413622cv:C0009447
Diseasecardiomyopathy (biomarker_via_orthology)

NOS1 NOS3

3.34e-0413622DOID:0050700 (biomarker_via_orthology)
Diseasemethylcobalamin deficiency type cblE, response to antineoplastic agent

KMT2A GAS7

3.34e-0413622GO_0097327, MONDO_0009354
Diseasetransient cerebral ischemia (implicated_via_orthology)

KMT2A NOS1 NOS3

3.36e-0464623DOID:224 (implicated_via_orthology)
DiseaseDepressive disorder

RNF123 FGF2 NOS1 ALK NOS3

3.57e-04289625C0011581
Diseasecardiovascular disease

ZDHHC18 FGF9 C1QTNF4 CADPS2 NOS3 REXO1

3.95e-04457626EFO_0000319
DiseaseCommon Variable Immunodeficiency

NFKB1 NFKB2

4.48e-0415622C0009447
Diseaseteratocarcinoma-derived growth factor 1 measurement

KMT2A GAS7

5.11e-0416622EFO_0008297
DiseaseAstrocytosis

FGF2 ITGA1

5.79e-0417622C3887640
DiseaseGliosis

FGF2 ITGA1

5.79e-0417622C0017639
DiseaseCleft Palate

FGF2 FGF9 NOS3

6.71e-0481623C0008925
Diseaseportal hypertension (implicated_via_orthology)

NOS1 NOS3

7.26e-0419622DOID:10762 (implicated_via_orthology)
DiseaseC-reactive protein measurement

ZDHHC18 POP5 APMAP NFKB1 CYP26C1 HAPLN4 C1QTNF4 ITGA1 DNAH11

8.91e-041206629EFO_0004458
Diseaseimpotence (biomarker_via_orthology)

NOS1 NOS3

9.77e-0422622DOID:1875 (biomarker_via_orthology)
DiseaseBronchiectasis

NFKB2 DNAH11

9.77e-0422622C0006267
Diseasehemoglobin change measurement

KMT2A GAS7

9.77e-0422622EFO_0600027
DiseaseS-6-hydroxywarfarin measurement

RAMP1 ADAMTS20 KMT2A GAS7 SEMA3E

1.06e-03368625EFO_0803326
Diseasesensory peripheral neuropathy, remission

KMT2A GAS7

1.07e-0323622EFO_0009785, MONDO_0002321
Diseaseneurotic disorder

FAM120A NOS1 SEMA3E

1.27e-03101623EFO_0004257
Diseasehypertension (biomarker_via_orthology)

CYP11B1 FGF2 NOS1 NOS3

1.34e-03227624DOID:10763 (biomarker_via_orthology)
DiseaseAntiglaucoma preparations and miotics use measurement

KMT2A GAS7

1.37e-0326622EFO_0009944
Diseaselissencephaly (implicated_via_orthology)

NOS1 NOS3

1.47e-0327622DOID:0050453 (implicated_via_orthology)
Diseasecystic fibrosis (is_implicated_in)

NOS1 NOS3

1.47e-0327622DOID:1485 (is_implicated_in)
Diseasecongestive heart failure (biomarker_via_orthology)

CYP11B1 NOS1 NOS3

1.50e-03107623DOID:6000 (biomarker_via_orthology)
Diseasechronic kidney disease (biomarker_via_orthology)

DGAT2 NOS3

1.59e-0328622DOID:784 (biomarker_via_orthology)
Diseasecerebral white matter volume change measurement, age at assessment

KMT2A GAS7

1.59e-0328622EFO_0008007, EFO_0021499
Diseaseleiomyoma (is_marker_for)

FGF2 NOS3

1.59e-0328622DOID:127 (is_marker_for)
Diseaseinterleukin-8 measurement

KMT2A GAS7

1.94e-0331622EFO_0004811
Diseasefatty liver disease (implicated_via_orthology)

DGAT2 NFKB1

1.94e-0331622DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
PGSGFRAHVYLCNRP

EOMES

261

O95936
ARGCLRCAFPHVLGY

GPR20

116

Q99678
LYCRTGFHLEIFPNG

FGF9

66

P31371
AAAGVFRCRLPGAYF

C1QTNF4

216

Q9BXJ3
YFHACVAGRLRFGPQ

DNAH11

4086

Q96DT5
PRRGIIFYHGGATVF

AADACL4

111

Q5VUY2
GHLYLGSFRSPFLCR

APMAP

396

Q9HDC9
GPGRLQLVCHVSGFY

CD1B

216

P29016
GRELYFYPGCCRRGS

DMWD

131

Q09019
HARLCGYFGTRAGPR

EFCC1

146

Q9HA90
AGPSDLRHCFYRGQV

ADAMTS20

121

P59510
VHGRYFRSCPISGRA

RAMP1

96

O60894
THFCRGGHFRYTLPV

NUDT8

156

Q8WV74
THGGTYRCFGSFRAL

KIR3DL2

286

P43630
HFRYCFPFGRPEGAL

CADPS

796

Q9ULU8
YPDCGGGRLDSHRAF

OGFOD2

206

Q6N063
GPGSCRGLDHDYSRY

KRT28

126

Q7Z3Y7
VLGRYLCRCRPGFYG

GPR179

311

Q6PRD1
RRAGYAHRQGYGPFL

MYO1A

621

Q9UBC5
FREERGGGFLCFHYR

GPATCH3

36

Q96I76
GGGFLCFHYRHRPER

GPATCH3

41

Q96I76
YAERAFFPGHGGCPL

PLXNB3

1336

Q9ULL4
PYRAFRVAAASGHCG

FAM120A

906

Q9NZB2
GFLACGPLYAYRCGH

ITGA1

126

P56199
FLGSFCRYHLTEPGL

SMPD4

771

Q9NXE4
VFGLGSRAYPHFCAF

NOS1

886

P29475
GLGSRAYPHFCAFAR

NOS3

651

P29474
LDRVYFGGFFIRGHP

PANK4

316

Q9NVE7
PLGFFSSHCDLDYGR

NTN3

146

O00634
GHRYPCFFNTLHVGG

POP5

91

Q969H6
IRGSGRNFYHVPFGF

CYP11B1

431

P15538
HFRYCFPFGRPEGAL

CADPS2

761

Q86UW7
RGASSRFHYIPFGGG

CYP26C1

441

Q6V0L0
RFHYIPFGGGARSCL

CYP26C1

446

Q6V0L0
LLYGFRVAPHFACAG

GJD3

156

Q8N144
YCKNGGFFLRIHPDG

FGF2

166

P09038
VGVYRSPIHGRGLFC

KMT2A

3831

Q03164
ALGPQHRAFGSYRGR

HAPLN4

101

Q86UW8
GYGVGFCRPTYLASR

KRTAP13-1

141

Q8IUC0
LEKHPRGGSFGYCFA

EMP3

126

P54852
FGRCQLAGYGFCHVP

B9D2

86

Q9BPU9
YIGFAPCIFHGRGLF

DGAT2

306

Q96PD7
GEFRFRHGYCKGNPR

RIOK1

226

Q9BRS2
KGRLCLYCGYPGHFA

RTL3

441

Q8N8U3
RPYCHFRHRGARGSG

REXO1

26

Q8N1G1
CPHGGYGLGLERFLT

NARS1

511

O43776
YLDLRRFGSVPHGGF

NARS2

431

Q96I59
CRTLYPFSGERHGQG

GAS7

6

O60861
LFRLRHFPCGNVNYG

ALK

1571

Q9UM73
YFCSRAERPRGGAAH

WNT8B

331

Q93098
RHLPGAFFLGAERGY

ZCCHC3

311

Q9NUD5
CSFSGYKIYPGHGRR

RPL24

6

P83731
LHGEFGSYPARGPRF

SPHK2

51

Q9NRA0
GCGFGYRYTRLPHLL

RNF123

976

Q5XPI4
YRGPFCGRARVHTDF

SASH1

551

O94885
YIRGCAFHHGFSPAI

PKHD1L1

3336

Q86WI1
RFYGHPCPFEGRRLG

MARS2

556

Q96GW9
PGGGLHRCLACARYF

ZNF593

56

O00488
RGAYGRPGSDFCHGT

ZNF792

86

Q3KQV3
RPGFRVCYICGREFG

ZNF474

91

Q6S9Z5
GAFDPVCAFIRVGYH

SEMA3E

136

O15041
YAGFPGCGLLRLHST

PPIP5K2

541

O43314
YPREGKYGHAACFGL

THOP1

416

P52888
GDYAGFPGCGLLRLH

PPIP5K1

551

Q6PFW1
EVFPGRNRFYCGGRL

ZDHHC18

71

Q9NUE0
GYSLRHQCPRCPRGF

ZBTB6

296

Q15916
RFRYVCEGPSHGGLP

NFKB1

56

P19838
FRFRYGCEGPSHGGL

NFKB2

51

Q00653