Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellular sodium-activated potassium channel activity

KCNT2 KCNT1

3.23e-0521142GO:0005228
HumanPhenoDisinhibition

DMXL2 DNAJC13 MID2 SPR RTTN BAZ1B SHOC2 MADD FANCD2 LINS1 PIK3CA DEPDC5 ATXN10 ATM HEPHL1 KCNT1 UNC80 KCNH5

5.62e-058074418HP:0000734
HumanPhenoInappropriate behavior

DMXL2 DNAJC13 MID2 SPR RTTN BAZ1B SHOC2 MADD FANCD2 LINS1 PIK3CA DEPDC5 ATXN10 ATM HEPHL1 KCNT1 UNC80 KCNH5

5.62e-058074418HP:0000719
HumanPhenoAbnormal response to social norms

DMXL2 DNAJC13 MID2 SPR RTTN BAZ1B SHOC2 MADD FANCD2 LINS1 PIK3CA DEPDC5 ATXN10 ATM HEPHL1 KCNT1 UNC80 KCNH5

5.62e-058074418HP:5200123
HumanPhenoSocial disinhibition

DMXL2 DNAJC13 MID2 SPR RTTN BAZ1B SHOC2 MADD FANCD2 LINS1 PIK3CA DEPDC5 ATXN10 ATM HEPHL1 KCNT1 UNC80 KCNH5

5.62e-058074418HP:5200029
HumanPhenoFocal motor seizure

DMXL2 PIK3CA DEPDC5 ATXN10 ERMARD KCNT1 KCNH5

1.10e-04131447HP:0011153
HumanPhenoAbnormal renal collecting system morphology

RTTN SHOC2 FANCD2 FANCE

1.13e-0430444HP:0004742
HumanPhenoAbnormality of multiple cell lineages in the bone marrow

ACD SRP54 UNC13D SHOC2 LYST FANCD2 FANCE LRBA

1.24e-04180448HP:0012145
DomainARM-type_fold

DNAJC13 CIP2A RTTN ARMH1 HEATR5A VIRMA LYST RYR3 URB1 AP2A1 AP2A2 CNOT9 CEBPZ PIK3CA ATXN10 NUP188 ATM LRBA UNC79 TNPO3 ARMC8

1.37e-1533911421IPR016024
Domain-

DNAJC13 CIP2A RTTN ARMH1 HEATR5A AP2A1 AP2A2 CNOT9 ATXN10 LRBA TNPO3 ARMC8

1.12e-08222114121.25.10.10
DomainARM-like

DNAJC13 CIP2A RTTN ARMH1 HEATR5A AP2A1 AP2A2 CNOT9 ATXN10 LRBA TNPO3 ARMC8

9.74e-0827011412IPR011989
Domain-

AP2A1 AP2A2

3.69e-05211422.60.40.1030
DomainClathrin_a-adaptin_app_Ig-like

AP2A1 AP2A2

3.69e-0521142IPR013038
DomainAP2_complex_asu

AP2A1 AP2A2

3.69e-0521142IPR017104
DomainClathrin_a-adaptin_app_sub_C

AP2A1 AP2A2

3.69e-0521142IPR003164
DomainAlpha_adaptin_C

AP2A1 AP2A2

3.69e-0521142PF02296
DomainClathrin_a/coatomer_app_sub_C

AP2A1 AP2A2

2.20e-0441142IPR015873
DomainBK_channel_a

KCNT2 KCNT1

2.20e-0441142PF03493
DomainK_chnl_Ca-activ_BK_asu

KCNT2 KCNT1

2.20e-0441142IPR003929
Domain-

AP2A1 AP2A2

2.20e-04411423.30.310.30
DomainPH_BEACH

LYST LRBA

5.45e-0461142PF14844
DomainPH-BEACH_dom

LYST LRBA

1.01e-0381142IPR023362
DomainCoatomer/calthrin_app_sub_C

AP2A1 AP2A2

1.01e-0381142IPR009028
Domain-

LYST LRBA

1.01e-03811422.30.29.40
DomainPH_BEACH

LYST LRBA

1.01e-0381142PS51783
DomainAlpha_adaptinC2

AP2A1 AP2A2

1.29e-0391142PF02883
DomainBEACH

LYST LRBA

1.29e-0391142PS50197
DomainBeach

LYST LRBA

1.29e-0391142PF02138
Domain-

LYST LRBA

1.29e-03911421.10.1540.10
DomainBeach

LYST LRBA

1.29e-0391142SM01026
DomainClathrin_a/b/g-adaptin_app_Ig

AP2A1 AP2A2

1.29e-0391142IPR008152
DomainBEACH_dom

LYST LRBA

1.29e-0391142IPR000409
DomainAlpha_adaptinC2

AP2A1 AP2A2

1.29e-0391142SM00809
DomainCoatomer/clathrin_app_Ig-like

AP2A1 AP2A2

2.34e-03121142IPR013041
DomainDnaJ

DNAJC13 DNAJB9 DNAJB14

3.14e-03481143PF00226
DomainDNAJ_1

DNAJC13 DNAJB9 DNAJB14

3.33e-03491143PS00636
DomainDNAJ_2

DNAJC13 DNAJB9 DNAJB14

3.33e-03491143PS50076
DomainDnaJ

DNAJC13 DNAJB9 DNAJB14

3.33e-03491143SM00271
Domain-

DNAJC13 DNAJB9 DNAJB14

3.33e-034911431.10.287.110
DomainClathrin/coatomer_adapt-like_N

AP2A1 AP2A2

3.68e-03151142IPR002553
DomainPI3/4_kinase_CS

PIK3CA ATM

3.68e-03151142IPR018936
DomainAdaptin_N

AP2A1 AP2A2

3.68e-03151142PF01602
DomainDnaJ_domain

DNAJC13 DNAJB9 DNAJB14

3.73e-03511143IPR001623
Domain-

PIK3CA ATM

4.19e-031611421.10.1070.11
DomainPI3Kc

PIK3CA ATM

4.19e-03161142SM00146
Domain-

DMXL2 TEP1 LYST ZNF106 PLXNA4 WDR12 LRBA

4.35e-0333311472.130.10.10
DomainWD40/YVTN_repeat-like_dom

DMXL2 TEP1 LYST ZNF106 PLXNA4 WDR12 LRBA

4.49e-033351147IPR015943
DomainWD40

DMXL2 TEP1 LYST ZNF106 WDR12 LRBA

5.15e-032591146PF00400
DomainPI3_PI4_kinase

PIK3CA ATM

5.30e-03181142PF00454
DomainPI3_4_KINASE_1

PIK3CA ATM

5.30e-03181142PS00915
DomainPI3_4_KINASE_2

PIK3CA ATM

5.30e-03181142PS00916
DomainPI3/4_kinase_cat_dom

PIK3CA ATM

5.30e-03181142IPR000403
DomainPI3_4_KINASE_3

PIK3CA ATM

5.30e-03181142PS50290
DomainWD40

DMXL2 TEP1 LYST ZNF106 WDR12 LRBA

6.06e-032681146SM00320
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MYCBP2 MARK3 RALGAPB DYRK4 VIRMA LYST MADD FSIP2 ZNF106 TBC1D4 STARD9 N4BP2 OSBPL8 TSSK1B UTRN TNPO3

2.65e-088611151636931259
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

DMXL2 DNAJC13 MYCBP2 MARK3 SYNE1 CIP2A COPE RALGAPB BAZ1B SRP54 DNAJB9 DNAJB14 GRAMD1B URB1 CEBPZ N4BP2 OSBPL8 WDR12 ATXN10 ATM

8.84e-0814871152033957083
Pubmed

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin.

FANCD2 FANCE ATM

3.50e-075115315199141
Pubmed

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.

CBLB AP2A1 AP2A2 PIK3CA

4.23e-0719115431959764
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

HEATR5A VIRMA DNAH1 STARD9 N4BP2 UNC79 KCNT1

8.18e-07153115710718198
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DMXL2 MYCBP2 SYNE1 RALGAPB URB1 AP2A2 OSBPL8 UNC80

8.84e-07225115812168954
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

MYCBP2 MARK3 RALGAPB SRP54 DNAJB9 FANCD2 URB1 AP2A2 CEBPZ PDE4DIP CEP135 WDR12 TNPO3

1.35e-067541151333060197
Pubmed

Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.

PIK3CA ATM EPHA3

2.92e-069115320838624
Pubmed

Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.

MYCBP2 CIP2A AP2A1 PIK3CA ATXN10

3.20e-0668115525754235
Pubmed

Functional proteomics mapping of a human signaling pathway.

MYCBP2 CBLB LAPTM5 PPP1R26 ZNF106 AP2A1 AP2A2 PDE4DIP CEP135 UTRN TNPO3

4.49e-065911151115231748
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DMXL2 VPS18 DNAJC13 MARK3 SYNE1 ZC3HC1 COPS3 VIRMA MADD GRAMD1B AP2A1 AP2A2 PDE4DIP PLXNA4 OSBPL8 UTRN ARMC8

4.86e-0614311151737142655
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DMXL2 MYCBP2 SYNE1 DNAJB9 ADARB1 RYR3 MADD MIA2 AP2A1 PDE4DIP OSBPL8 ATXN10 ATM LRBA UTRN ARMC8

5.28e-0612851151635914814
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

CIP2A COPE COPS3 POLR3C AP2A2 CNOT9 ATXN10 TNPO3

5.52e-06288115823383273
Pubmed

The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.

BAZ1B FANCD2 ATM

5.70e-0611115324800743
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DMXL2 VPS18 CIP2A LAPTM5 PPP1R26 AP2A2 N4BP2 CEP135 OSBPL8 UNC80

5.91e-064931151015368895
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MARK3 SYNE1 RALGAPB HEATR5A VIRMA MADD GRAMD1B STARD9 PDE4DIP

8.89e-06407115912693553
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

DNAJC13 MYCBP2 CIP2A COPE RALGAPB SHOC2 MADD FANCD2 CCNH TBC1D4 CEBPZ CEP135 ATXN10 UTRN

9.96e-0610491151427880917
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

VPS18 SPR MARK3 CBLB LYST GRAMD1B CCNH AP2A1 AP2A2 PDE4DIP OSBPL8 NUP188 UTRN

1.03e-059101151336736316
Pubmed

Can serum resistin predict severity of acute pancreatitis?

CRP RETN

1.08e-052115233089708
Pubmed

Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.

KCNT2 KCNT1

1.08e-052115225347289
Pubmed

Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.

KCNT2 KCNT1

1.08e-052115217344399
Pubmed

Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins).

AP2A1 AP2A2

1.08e-05211522564002
Pubmed

Insights into Fanconi Anaemia from the structure of human FANCE.

FANCD2 FANCE

1.08e-052115217308347
Pubmed

ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery Disease and Large Artery Ischemic Stroke.

ZC3HC1 ADAMTS7

1.08e-052115231679296
Pubmed

Serum resistin and high sensitive CRP levels in patients with subclinical hypothyroidism before and after L-thyroxine therapy.

CRP RETN

1.08e-052115223518675
Pubmed

Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

KCNT2 KCNT1

1.08e-052115226845140
Pubmed

Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.

PIK3CA ATM

1.08e-052115216728507
Pubmed

Molecular mechanisms of Slo2 K+ channel closure.

KCNT2 KCNT1

1.08e-052115227682982
Pubmed

Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with C-reactive protein in Chinese Han patients with spontaneous basal ganglia hemorrhage.

CRP RETN

1.08e-052115222869540
Pubmed

Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin.

CRP RETN

1.08e-052115218023360
Pubmed

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

KCNT2 KCNT1

1.08e-052115226587966
Pubmed

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways.

FANCD2 ATM

1.08e-052115212086603
Pubmed

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.

KCNT2 KCNT1

1.08e-052115230796290
Pubmed

Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene.

AP2A1 AP2A2

1.08e-052115212036598
Pubmed

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.

CBLB ATM

1.08e-052115217364027
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

MARK3 RALGAPB CBLB AP2A1 PIK3CA OSBPL8 LRBA UTRN EPHA3

1.16e-05421115936976175
Pubmed

APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.

TFAP2B AP2A1 AP2A2

1.25e-0514115329262337
Pubmed

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

MYCBP2 MARK3 AP2A1 AP2A2

1.39e-0544115426471122
Pubmed

The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.

FANCD2 FANCE ATM

1.56e-0515115319536649
Pubmed

Mutations in UNC80, Encoding Part of the UNC79-UNC80-NALCN Channel Complex, Cause Autosomal-Recessive Severe Infantile Encephalopathy.

UNC79 UNC80

3.24e-053115226708753
Pubmed

Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.

AP2A1 AP2A2

3.24e-053115235014951
Pubmed

A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.

AP2A1 AP2A2

3.24e-053115218032517
Pubmed

Genetic variants in components of the NALCN-UNC80-UNC79 ion channel complex cause a broad clinical phenotype (NALCN channelopathies).

UNC79 UNC80

3.24e-053115230167850
Pubmed

Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection.

SCGB1A1 ATM

3.24e-053115235196880
Pubmed

Interleukin-6 up-regulates the expression of interleukin-15 is associated with MAPKs and PI3-K signaling pathways in the human keratinocyte cell line, HaCaT.

IL15 PIK3CA

3.24e-053115221769475
Pubmed

Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis.

CRP RETN

3.24e-053115221325757
Pubmed

The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC.

FANCD2 FANCE

3.24e-053115216513431
Pubmed

Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.

UNC79 UNC80

3.24e-053115221040849
Pubmed

Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.

UNC79 UNC80

3.24e-053115232620897
Pubmed

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

AP2A1 AP2A2

3.24e-053115222262466
Pubmed

Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.

AP2A1 AP2A2

3.24e-053115226269175
Pubmed

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

KCNT2 KCNT1

3.24e-053115226559620
Pubmed

Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.

FANCD2 ATM

3.24e-053115216943440
Pubmed

Predictive Value of the TP53/PIK3CA/ATM Mutation Classifier for Patients With Bladder Cancer Responding to Immune Checkpoint Inhibitor Therapy.

PIK3CA ATM

3.24e-053115234421886
Pubmed

A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.

AP2A1 AP2A2

3.24e-053115219129443
Pubmed

Interaction of Shc with adaptor protein adaptins.

AP2A1 AP2A2

3.24e-05311528617812
Pubmed

Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children.

CRP RETN

3.24e-053115223729554
Pubmed

The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein.

AP2A1 AP2A2

3.24e-05311528662627
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

CIP2A AP2A1 AP2A2 ATXN10 TNPO3 ARMC8

3.42e-05183115623956138
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

DMXL2 NEBL INPP1 RALGAPB BAZ1B ZC3HC1 TGM6 VIRMA KIF24 LAPTM5 ZNF106 AP2A2 CNOT9 ATXN10

6.32e-0512421151430973865
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYCBP2 BAZ1B VIRMA URB1 CEBPZ OSBPL8 WDR12 NUP188 ATM UTRN

6.47e-056531151022586326
Pubmed

Evaluation of serum adipokines in peripheral arterial occlusive disease.

CRP RETN

6.48e-054115222547903
Pubmed

Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.

TFAP2B AP2A1

6.48e-054115212749383
Pubmed

Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate.

AP2A1 AP2A2

6.48e-054115220500056
Pubmed

FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway.

FANCD2 FANCE

6.48e-054115216127171
Pubmed

EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway.

PIK3CA EPHA3

6.48e-054115227101199
Pubmed

The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.

AP2A1 AP2A2

6.48e-054115212646615
Pubmed

A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint.

FANCD2 ATM

6.48e-054115215377654
Pubmed

Association and colocalization of Eps15 with adaptor protein-2 and clathrin.

AP2A1 AP2A2

6.48e-05411529049247
Pubmed

FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.

FANCD2 ATM

6.48e-054115218931676
Pubmed

The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.

UNC79 UNC80

6.48e-054115232494638
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SYNE1 COPE BAZ1B COPS3 FANCD2 URB1 AP2A1 AP2A2 CEBPZ STARD9 WDR12 ATXN10 NUP188 ATM ARMC8

7.34e-0514251151530948266
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MYCBP2 RTTN TEP1 LYST MADD PPP1R26 URB1 AP2A1 ADAMTS7 DEPDC5 NUP188 LRBA TNPO3

7.66e-0511051151335748872
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

MARK3 CIP2A COPE COPS3 FANCD2 GRAMD1B URB1 AP2A2 CNOT9 CEBPZ OSBPL8 NUP188 ATM TNPO3 ARMC8

8.25e-0514401151530833792
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

CIP2A SRP54 FANCD2 AP2A1 AP2A2 UTRN

8.36e-05215115635973513
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DMXL2 DNAJC13 MYCBP2 SYNE1 VIRMA AP2A1 AP2A2 N4BP2 PDE4DIP UNC79 KCNT1 ARMC8

8.58e-059631151228671696
Pubmed

Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.

VIRMA KIF24 CEP135

9.72e-0527115335709258
Pubmed

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.

ACD ATM

1.08e-045115217948054
Pubmed

Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.

PIK3CA ATM

1.08e-045115220177704
Pubmed

Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.

AP2A1 AP2A2

1.08e-045115216139856
Pubmed

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.

AP2A1 AP2A2

1.08e-045115231671891
Pubmed

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.

FANCD2 FANCE

1.08e-045115219704162
Pubmed

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

CBLB PIK3CA

1.08e-045115211526404
Pubmed

Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.

SLC7A2 UTRN

1.08e-045115223009292
Pubmed

Weak Molecular Interactions in Clathrin-Mediated Endocytosis.

AP2A1 AP2A2

1.08e-045115229184887
Pubmed

Association of inflammatory and other immune markers with gallbladder cancer: Results from two independent case-control studies.

CRP RETN

1.08e-045115227173614
Pubmed

A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.

AP2A1 AP2A2

1.08e-045115217108326
Pubmed

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.

AP2A1 AP2A2

1.08e-04511529723620
Pubmed

Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder.

INPP1 TFAP2B

1.08e-045115216787706
Pubmed

Perforin is a critical physiologic regulator of T-cell activation.

UNC13D LYST

1.08e-045115221606480
Pubmed

Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.

AP2A1 AP2A2

1.08e-045115215941406
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

SYNE1 COPE COPS3 SHOC2 KIF24 FANCE ZNF106 URB1 AP2A1 CNOT9 CEP135 NUP188 ATM

1.19e-0411551151320360068
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DNAJC13 RASA2 MID2 MYCBP2 MARK3 RALGAPB SRP54 TEP1 ADARB1 DNAH1 TBC1D4 LRBA ERMARD UTRN FRMD3

1.19e-0414891151528611215
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SYNE1 BAZ1B URB1 CEBPZ OSBPL8 WDR12 NUP188

1.23e-04332115725693804
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

NEBL MARK3 SYNE1 RALGAPB BAZ1B SRP54 VIRMA CCNH URB1 CNOT9 CEBPZ OSBPL8 WDR12 UTRN ARMC8

1.27e-0414971151531527615
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

VPS18 MARK3 RALGAPB OXGR1 UNC13D DNAJB9 VIRMA FANCD2 LINS1 ZNF106 PIK3CA CEP135 DEPDC5 NUP188

1.27e-0413271151432694731
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

SYNE1 ADARB1 VIRMA KIAA1549L LRBA TNPO3

1.33e-04234115636243803
Pubmed

Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.

FANCD2 FANCE ATM

1.48e-0431115319690177
Pubmed

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect.

UNC13D LYST

1.61e-046115238722309
Pubmed

Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.

AP2A1 AP2A2

1.61e-046115222713487
InteractionFPR1 interactions

DMXL2 CIP2A FANCD2 SLC7A2 URB1 CNOT9 ATM TNPO3

1.35e-061471098int:FPR1
InteractionEFNA4 interactions

DMXL2 VPS18 CIP2A URB1 PDE4DIP ATM LRBA TNPO3 EPHA3

6.08e-062391099int:EFNA4
InteractionH2BC9 interactions

BAZ1B TEP1 ADARB1 VIRMA DNAH1 FSIP2 TBC1D4 CEBPZ PDE4DIP DEPDC5 EPHA3

3.02e-0544610911int:H2BC9
InteractionSTX6 interactions

VPS18 MARK3 RALGAPB HEATR5A SLC7A2 AP2A1 AP2A2 OSBPL8 LRBA UTRN ARMC8

3.14e-0544810911int:STX6
InteractionDUXAP9 interactions

STYK1 CBLB VIRMA

3.27e-05121093int:DUXAP9
InteractionPCDHA3 interactions

MYCBP2 KCNT2 CNOT9 ABCD4

3.31e-05341094int:PCDHA3
Cytoband15q14-q15

VPS18 RYR3

6.19e-055115215q14-q15
GeneFamilyPotassium sodium-activated channel subfamily T

KCNT2 KCNT1

1.70e-052752856
GeneFamilyWD repeat domain containing|BEACH domain containing

LYST LRBA

6.00e-0497521230
GeneFamilyDNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing

DNAJC13 DNAJB9 DNAJB14

1.10e-0349753584
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000

DNAJC13 CIP2A HEATR5A RNF17 KIF24 FANCD2 URB1 NUP188 ATM ERMARD

7.82e-0633310810gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 BAZ1B SRP54 LYST ZNF106 MIA2 CEBPZ UTRN

2.55e-0818411481154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 RTTN CBLB STARD9 ATM LRBA UTRN

7.68e-071971147e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF17 RYR3 DNAH1 PLXNA4 UNC79 UNC80

4.90e-06169114612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CIP2A TFAP2B LAPTM5 FANCD2 CEP135 FRMD3

5.24e-06171114641932c9e70829ee3d55ca5fdb74d290fc8229416
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARMH1 CBLB ADARB1 LYST PIK3CA UTRN

5.60e-061731146694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellSevere-B_naive-8|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARMH1 CBLB ADARB1 LYST LAPTM5 UTRN

5.79e-061741146f3f8c924420f46321bd47e2b97f18c7241541599
ToppCellHealthy/Control-pDC|World / Disease group and Cell class

DCDC1 HMSD GRAMD1B TBC1D4 PLXNA4 P2RY14

7.49e-06182114697e0eee10905f2cf2bebb09e474629fc224f4397
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

RGS7BP MYCBP2 ZNF106 OSBPL8 UTRN EPHA3

7.97e-06184114667164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RGS7BP SLC7A2 KCNT2 STARD9 KCNT1 EPHA3

9.29e-061891146fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RGS7BP CBLB SLC7A2 STARD9 UTRN EPHA3

9.86e-06191114604c4d454b57e29a8d1dcdeb4678ce71bdc29b77b
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARMH1 CBLB ADARB1 LYST PIK3CA UTRN

1.11e-0519511460a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 RTTN CBLB ATM LRBA UTRN

1.25e-051991146f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR3 KIAA1549L KCNT2 HEPHL1 UNC80

5.74e-051601145c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR3 KIAA1549L KCNT2 HEPHL1 UNC80

5.74e-05160114525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CIP2A OXGR1 KIAA1549L HEPHL1 UNC80

6.09e-051621145bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellSevere-Lymphoid-NK-CD8_T|Severe / Condition, Lineage, Cell class and cell subclass

SYNE1 STYK1 CBLB STARD9 CUZD1

7.03e-0516711458d41015871616ab7eced5104cd8f70d0efe504f2
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ADARB1 LAPTM5 PIK3CA P2RY14 HEPHL1

7.43e-051691145c3a6179a64589a370108fea809b157839347759c
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

IL15 SYNE1 ADARB1 KCNT2 EPHA3

8.08e-05172114536a96714a0eb6ac438648135336c9791881ddadb
ToppCelldroplet-Marrow-nan-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEP1 FANCD2 PPP1R26 SCGB1A1 ABCD4

8.30e-0517311456d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCellCOVID-19_Moderate-NK_CD56bright|COVID-19_Moderate / disease group, cell group and cell class

INPP1 STYK1 CBLB LYST PLXNA4

8.30e-051731145a07dcb1e555caaa2235aec219334fcbf2d07f10c
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRP54 LYST ZNF106 TBC1D4 KCNT2

9.00e-051761145749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CIP2A LYST PPP1R26 MIA2 DEPDC5

9.00e-05176114576fdf211bce101e83a27d822cb399487bd107027
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYNE1 BAZ1B SRP54 LYST UTRN

9.49e-05178114501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL CBLB RYR3 KCNT2 FRMD3

9.75e-0517911457394e77e665bf16d3733df91bb12907be460ab44
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL CRPPA TFAP2B PDE4DIP PLXNA4

9.75e-05179114555bc69f107fc710db7617c428575792adfdbbcc1
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NEBL ADARB1 SLC7A2 PLXNA4 FRMD3

1.00e-04180114508ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCelldroplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRPPA TFAP2B ADAMTS7 LRRC8B UNC80

1.05e-0418211456fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL CBLB RYR3 KCNT2 FRMD3

1.08e-041831145848fc6dd129150897ee339343e83c645b6e779eb
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-MPO+_mono-neutrophil|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CIP2A LYST KIF24 FANCD2 RETN

1.08e-04183114501c7f01498a9894920edf8243e41187cbdf90688
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL CBLB RYR3 KCNT2 PDE4DIP

1.08e-0418311457c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 RYR3 DNAH1 UNC79 UNC80

1.11e-0418411452cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 RYR3 DNAH1 UNC79 UNC80

1.11e-041841145ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EFCAB6 RYR3 DNAH1 UNC79 UNC80

1.11e-0418411452b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP ADARB1 TBC1D4 UNC79 UNC80

1.14e-041851145cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

DMXL2 MYCBP2 CBLB URB1 LRBA

1.14e-041851145a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

HMSD GRAMD1B TBC1D4 PLXNA4 P2RY14

1.14e-0418511457fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCelldroplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 ADARB1 SLC7A2 SCGB1A1 CUZD1

1.17e-041861145f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCelldroplet-Lung-nan-21m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 ADARB1 SLC7A2 SCGB1A1 CUZD1

1.17e-0418611458f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

DMXL2 MYCBP2 CBLB URB1 LRBA

1.17e-0418611458571956890fc9894d766ba294a28e376b4aba428
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGS7BP SLC7A2 P2RY14 FRMD3 EPHA3

1.17e-0418611450c477016c1b539b3086a8066c3c6443f08c222a3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A2 KCNT2 STARD9 KCNT1 EPHA3

1.20e-04187114548bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

HMSD GRAMD1B TBC1D4 PLXNA4 P2RY14

1.20e-041871145aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A2 KCNT2 STARD9 KCNT1 EPHA3

1.20e-041871145958402fcc78f4c7a7d13d659d776f3817137975f
ToppCell(1)_T_CD4_naive|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ARMH1 LINS1 TBC1D4 N4BP2 ATM

1.23e-041881145b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGS7BP ADARB1 TFAP2B UNC80 FRMD3

1.23e-0418811451efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NEBL SYNE1 TBC1D4 LRBA UTRN

1.26e-041891145830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASA2 SYNE1 CBLB ATM UTRN

1.29e-041901145d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

MYCBP2 CBLB LYST URB1 LRBA

1.32e-0419111459454f642c3621370fa23640b631301346b300950
ToppCellControl-Lymphoid_T/NK-NK_CD56bright|Control / Disease group, lineage and cell class

SYNE1 STYK1 CBLB STARD9 UTRN

1.32e-041911145e842f29bc03ed6734b2a7b975e7830a498f2743c
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PDE4DIP PLXNA4 LRBA UTRN FRMD3

1.35e-0419211456c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCellCOPD-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

SYNE1 LYST MADD PLXNA4 UTRN

1.39e-0419311450020249fa71afb500af73700543bb6f349be6b10
ToppCellnormal_Lymph_Node-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

IL15 LYST HMSD TBC1D4 CEP135

1.39e-041931145024d30eb143d8278c0851c3a6c9426226fa3b480
ToppCellLPS-antiTNF-Stromal_mesenchymal|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ADARB1 SLC7A2 PLXNA4 EPHA3

1.42e-0419411456e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RGS7BP ADARB1 SLC7A2 KCNT2 UTRN

1.42e-0419411455c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RGS7BP ADARB1 SLC7A2 KCNT2 UTRN

1.42e-041941145ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCellILEUM-inflamed-(2)_B_cell-(2)_Naive_B_cells|(2)_B_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DNAJB9 ADARB1 LYST LAPTM5 P2RY14

1.42e-041941145a89e67a40382600739be92e395bf47dd44aa4122
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYCBP2 MCMDC2 CBLB LRBA UTRN

1.45e-0419511454b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCellT_cells-GZMK+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

IL15 SYNE1 CBLB LYST UTRN

1.45e-041951145003ea7ddec6c1c98d2f6470bb51ebd97450eb936
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYCBP2 MCMDC2 CBLB LRBA UTRN

1.49e-041961145c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

CBLB LYST HMSD TBC1D4 CEP135

1.53e-041971145c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCellControl-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARMH1 CBLB ADARB1 LAPTM5 PIK3CA

1.53e-041971145925bf0d38e4ce279fa45f455546ebd199282c0df
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGS7BP SYNE1 KIAA1549L UNC79 UNC80

1.56e-0419811454ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 CBLB CCNH ATM UTRN

1.64e-042001145d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

MYCBP2 SYNE1 KIAA1549L UNC79 UNC80

1.64e-04200114548d801219bc771d6c7e151dc88ca4c179988de85
ToppCellmild-gd_T|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 CBLB CEBPZ ATM UTRN

1.64e-042001145109f673a4967ffa52270a0b4f818b3461288db44
Diseasestroke, coronary artery disease

ZC3HC1 ADAMTS7 WDR12

6.74e-05211123EFO_0000712, EFO_0001645
Diseasesmoking behavior, body mass index

DMXL2 RASA2 CHRNB4 ADAMTS7 EPHA3

1.09e-041231125EFO_0004318, EFO_0004340
DiseaseCoronary Arteriosclerosis

ZC3HC1 CRP ADAMTS7 WDR12

1.11e-04651124C0010054
DiseaseCoronary Artery Disease

ZC3HC1 CRP ADAMTS7 WDR12

1.11e-04651124C1956346
Diseaselarge artery stroke, coronary artery disease

ZC3HC1 CHRNB4 WDR12

1.15e-04251123EFO_0001645, EFO_0005524
Diseasecathepsin H measurement

CHRNB4 ADAMTS7

2.96e-0471122EFO_0020243
DiseaseAutosomal Dominant Nocturnal Frontal Lobe Epilepsy

DEPDC5 KCNT1

2.96e-0471122C3696898
DiseaseMalignant Head and Neck Neoplasm

FANCD2 FANCE PIK3CA

6.29e-04441123C0278996
Diseasecomparative body size at age 10, self-reported

RGS7BP RASA2 DNAJB9 TFAP2B KCNT2 CNOT9 SCGB1A1

1.13e-034201127EFO_0009819
Diseaseleukemia

FANCD2 FANCE ATM

1.21e-03551123C0023418
DiseaseFanconi anemia

FANCD2 FANCE

1.26e-03141122cv:C0015625
Diseasecigarettes per day measurement

DCDC1 ADARB1 CHRNB4 CRP ADAMTS7 LRBA EPHA3

1.44e-034381127EFO_0006525
Diseaseanxiety

EFCAB6 MADD DNAH1 PLXNA4 UNC80

1.64e-032231125EFO_0005230
DiseaseBenign neoplasm of stomach

PIK3CA ATM

1.87e-03171122C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

PIK3CA ATM

1.87e-03171122C0496905
DiseaseCarcinoma in situ of stomach

PIK3CA ATM

1.87e-03171122C0154060
DiseaseCCL5 measurement

SYNE1 ATXN10 UTRN

1.87e-03641123EFO_0005117
DiseaseBone marrow hypocellularity

FANCD2 FANCE

2.10e-03181122C1855710
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RASA2 SHOC2

2.34e-03191122C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

RASA2 SHOC2

2.34e-03191122C1843181
DiseaseCardio-facio-cutaneous syndrome

RASA2 SHOC2

2.34e-03191122C1275081
DiseaseCostello syndrome (disorder)

RASA2 SHOC2

2.34e-03191122C0587248
Diseasestomach cancer (is_implicated_in)

CAPN9 TEP1 PIK3CA

2.62e-03721123DOID:10534 (is_implicated_in)
Diseasetype 1 diabetes mellitus (is_marker_for)

IL15 CRP RETN

2.62e-03721123DOID:9744 (is_marker_for)
DiseaseBREAST CANCER

PIK3CA ATM

2.86e-03211122114480
Diseaseectonucleoside triphosphate diphosphohydrolase 5 measurement

DNAL1 ABCD4

2.86e-03211122EFO_0008115
DiseaseStomach Carcinoma

PIK3CA ATM

2.86e-03211122C0699791
DiseaseMetabolic Syndrome X

CRP RETN

2.86e-03211122C0524620
Diseaserenal system measurement, blood urea nitrogen measurement

DCDC1 TFAP2B

3.14e-03221122EFO_0004741, EFO_0004742
DiseaseLEOPARD Syndrome

RASA2 SHOC2

3.14e-03221122C0175704
DiseasePrimary microcephaly

RTTN CEP135

3.14e-03221122C0431350
DiseaseNasopharyngeal carcinoma

SYNE1 PIK3CA

3.14e-03221122C2931822
DiseaseCarcinoma of lung

PIK3CA EPHA3

3.43e-03231122C0684249
Diseaseepilepsy (implicated_via_orthology)

KCNT2 DEPDC5 KCNT1 KCNH5

3.51e-031631124DOID:1826 (implicated_via_orthology)
Diseaselung squamous cell carcinoma (is_implicated_in)

CHRNB4 ATM

3.73e-03241122DOID:3907 (is_implicated_in)
DiseaseNoonan Syndrome

RASA2 SHOC2

3.73e-03241122C0028326

Protein segments in the cluster

PeptideGeneStartEntry
GEKMTLCISVLLALT

CHRNB4

261

P30926
LMLKENRTCLSQLLD

CCNH

236

P51946
MTQLCELINKSGELL

COPS3

21

Q9UNS2
LLDVLCEMTVNTELL

ATXN10

306

Q9UBB4
LSCMVKTEQCLVALL

BAZ1B

1426

Q9UIG0
MTDSCLEKLLRSIGI

ARMH1

71

Q6PIY5
MDSVKQSAALCLLRL

AP2A1

161

O95782
LCLRIMESGSELSKT

CNOT9

166

Q92600
LECTAMTVQILLKLD

COPE

146

O14579
ACLKILMTELRTLAT

DMXL2

2046

Q8TDJ6
LLDMSLKSQDCEILG

ABCD4

351

O14678
EDTKLCRCLSTMDLI

SLC7A2

26

P52569
AICILMITELILASK

DNAJB9

11

Q9UBS3
ETLLTVRLKDICSMT

GRAMD1B

146

Q3KR37
DTAILLTRKDLCAAM

ADAMTS7

336

Q9UKP4
MDSVKQSAALCLLRL

AP2A2

161

O94973
MLLATKQLCKEFTDL

TFAP2B

356

Q92481
TTEMLKSICLLGSLQ

RGS7BP

136

Q6MZT1
FTLSLLKLQKMEEAC

RASA2

766

Q15283
TQKLLSMLEESSLCI

CRPPA

351

A4D126
MLCKHTTSLLTLDIQ

LRRC9

781

Q6ZRR7
LSALLEMEASQKCLG

DEPDC5

1041

O75140
TLLLEECTEKLNLNM

DCDC1

196

M0R2J8
MSDILRELLCVSEKA

INPP1

1

P49441
CQMEILELKRTASAL

KRT40

301

Q6A162
MLECLSLSDNKLTEL

LRRD1

396

A4D1F6
DTSKIVNILMCFLDL

LINS1

241

Q8NG48
MLDLLKCTVLSLEQS

MADD

1011

Q8WXG6
LLKLCLLMSLVQTTD

MCMDC2

321

Q4G0Z9
TAMKCFLLELQVISL

IL15

86

P40933
VLCVSSLKIDLLMDF

KCNT1

356

Q5JUK3
ELKEDIQLLSCRMTA

KCNH5

916

Q8NCM2
LEAMALKSTIDLTCN

CBLB

211

Q13191
CKLLMIAENVLTEIS

FSIP2

2856

Q5CZC0
KMKSLDESALCIFIL

PLXNA4

346

Q9HCM2
EMLSLLKLACVDTSL

OR2V2

181

Q96R30
LDEIMVLKSKCIQSL

KIF24

1331

Q5T7B8
TICSTLLAFIMELLK

LRBA

496

P50851
CQMSSKLLVKTVLFL

KIAA1549L

821

Q6ZVL6
HVVLCVSSLKIDLLM

KCNT2

301

Q6UVM3
KLSCSDTSMNELLLL

OR5J2

186

Q8NH18
FKLCVTKEMLLLSIT

MFSD11

231

O43934
ACSDTSLLELMVILL

OR6C4

186

Q8NGE1
LQGERLLTMSCSDKI

ADARB1

546

P78563
SMLLSSEQLKLCVLE

PIK3CA

231

P42336
MITLTELKCLADAQS

LRRC8B

1

Q6P9F7
KLACTDTFTLELLMI

OR4D9

186

Q8NGE8
KSSTIIMLNLACTDL

OXGR1

66

Q96P68
ELALKCSSLLKRTMI

OSBPL8

261

Q9BZF1
LEETMAKLQLELNLC

CEP135

361

Q66GS9
KSLSQEMRCTIRLLD

FRMD3

26

A2A2Y4
MLDSLRDCNKILDLV

DNAH1

1296

Q9P2D7
TLSVLKCLQMLSVEK

DYRK4

211

Q9NR20
LVLEKILVSLTMKNC

ATM

606

Q13315
LLTSKLMNDIADICK

ATM

806

Q13315
EILVVASSMLCNLLL

ARMC8

441

Q8IUR7
KIIMTLAEDLLCSAA

HEATR5A

526

Q86XA9
CAVDLLTQLSSILKM

HEATR5A

641

Q86XA9
QSCVLLLKAKESSLM

EFCAB6

1386

Q5THR3
LSMDNCKELERLTSL

DNAJB14

361

Q8TBM8
MEKLLCFLVLTSLSH

CRP

1

P02741
MDCQLSILLLLSCSV

EPHA3

1

P29320
TDLATLILNMLITMC

DNAJC13

1041

O75165
ICMLELNLLSASKAK

LYST

1271

Q99698
VILSLRLCSAMKQTD

HEPHL1

1131

Q6MZM0
MSTDCENLLKRFLVL

MARK3

276

P27448
FLLQLTELTLNMCLE

HMSD

11

P0C7T4
AISLSLMKLTSCLER

ERMARD

121

Q5T6L9
QTELLCCLVKMESLE

FANCE

416

Q9HB96
TLLILSCLAELTMAE

CUZD1

11

Q86UP6
DASLSMLANCEKLSL

DNAL1

41

Q4LDG9
LSLISCKNIISLMDT

CAPN9

561

O14815
QCLMALDTFKELLIT

CEBPZ

281

Q03701
LVLKDMCSSILSLAQ

FANCD2

426

Q9BXW9
EIQMSTKESDFLCLL

MIA2

106

Q96PC5
KLVCVDTSLVQLIML

OR13F1

186

Q8NGS4
LMDDSLMQISLQLLC

RTTN

1961

Q86VV8
INKILLCMDDVELSL

UTRN

1876

P46939
EVLNAMLKEVCTALL

SRP54

26

P61011
CSELEAKQMLLKSLI

SYNE1

4391

Q8NF91
LMTLQLLDFCLSILT

LAPTM5

136

Q13571
ELALCSKLSIMSIEN

SHOC2

536

Q9UQ13
QELCIVMCLKDLTSI

MYCBP2

3731

O75592
MSILCSDTNELELII

OR8K1

191

Q8NGG5
LMCAEAILDISKTIL

PPP1R26

481

Q5T8A7
SSLDCVLDLTMLKIH

STARD9

2356

Q9P2P6
MKEFTLLLSAANVCL

P2RY14

276

Q15391
ELMASTLETCKGLLR

URB1

2046

O60287
MLCISENDQLILSSL

ACD

226

Q96AP0
MDSTACLKSLLLTVS

CIP2A

1

Q8TCG1
ENLKTMGRLSLECSL

RNF17

1016

Q9BXT8
MLLECSLSDKLCVIQ

STYK1

6

Q6J9G0
TMCLTEDKISLLLHL

ZC3HC1

206

Q86WB0
MKLAVTLTLVTLALC

SCGB1A1

1

P11684
SIIKLMEKIAQSSLC

SCGB1A1

76

P11684
LKMAACQLLLEITTF

UNC80

1341

Q8N2C7
MTQAEIKLCSLLLQE

POLR3C

1

Q9BUI4
LQEKKMALLSLLCST

TEP1

241

Q99973
AFLLMDTKECLLSTE

SPO16

56

Q5VVC0
QMSTETLKTLLALGC

RYR3

921

Q15413
LNLTSMLCLTSSVLK

SPR

126

P35270
QLCMSLGKDTLLRID

VPS18

66

Q9P253
SILETCALIMKIICL

NUP188

1031

Q5SRE5
KDAAEATLTCIMQLL

RALGAPB

896

Q86X10
LSLLSSQETLIMECE

TBC1D4

1121

O60343
LSELCSVQVMALKKL

TNPO3

581

Q9Y5L0
IEILAMLNHCSIIKT

TSSK1B

61

Q9BXA7
KDSLSCLLLSASMDQ

WDR12

151

Q9GZL7
LFSLKMETLESELTC

MID2

16

Q9UJV3
VLGLLVSSKTLCSME

RETN

11

Q9HD89
ARCTLTLLKTMLTEL

VIRMA

1006

Q69YN4
ISLKELCQLRMSSSE

UNC13D

561

Q70J99
ISLREEELSKSLQCM

ZNF106

1056

Q9H2Y7
LTEDKKILLAAMCLV

TGM6

576

O95932
VKDALLCDAMTLVNL

TTLL13

406

A6NNM8
KCSLDSSLRIMICLL

UNC79

2191

Q9P2D8
AMAKSLTIDCLELAL

N4BP2

1366

Q86UW6
RNTMLSLCLENAELK

PDE4DIP

1046

Q5VU43
DLSMELARKCTELIS

NEBL

36

O76041