Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	creatine kinase activity	CKB CKM	2.98e-04	6	90	2	GO:0004111
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A7 SLC4A8	2.98e-04	6	90	2	GO:0008510
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A7 SLC4A8 SLC26A6	4.00e-04	32	90	3	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A7 SLC4A8 SLC26A6	4.00e-04	32	90	3	GO:0005452
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	NET1 DOCK9 DENND4B SBF2 SH3BP1 TBC1D25 ARHGAP8 PLEKHG5 FAM13B	4.66e-04	507	90	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	NET1 DOCK9 DENND4B SBF2 SH3BP1 TBC1D25 ARHGAP8 PLEKHG5 FAM13B	4.66e-04	507	90	9	GO:0030695
GeneOntologyMolecularFunction	phosphotransferase activity, nitrogenous group as acceptor	CKB CKM	5.53e-04	8	90	2	GO:0016775
GeneOntologyCellularComponent	SCF ubiquitin ligase complex	FBXO38 FBXW5 USP47 FBXW11	2.47e-04	70	91	4	GO:0019005
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	FBXO38 KLHL9 FBXW5 ZSWIM4 USP47 FBXW11	3.30e-04	212	91	6	GO:0031461
Domain	ARM-type_fold	TNPO1 PPP2R1B PIK3CA DOCK9 PKP1 SERAC1 HEATR5A ARID1A WDFY4	3.41e-05	339	89	9	IPR016024
Domain	-	TNPO1 PPP2R1B PKP1 SERAC1 HEATR5A ARID1A WDFY4	9.20e-05	222	89	7	1.25.10.10
Domain	ATP-gua_PtransN	CKB CKM	1.34e-04	4	89	2	PF02807
Domain	PHOSPHAGEN_KINASE	CKB CKM	1.34e-04	4	89	2	PS00112
Domain	ATP-guanido_PTrfase_N	CKB CKM	1.34e-04	4	89	2	IPR022413
Domain	ATP-guanido_PTrfase_AS	CKB CKM	1.34e-04	4	89	2	IPR022415
Domain	ATP-guanido_PTrfase_cat	CKB CKM	1.34e-04	4	89	2	IPR022414
Domain	ATP-gua_Ptrans	CKB CKM	1.34e-04	4	89	2	PF00217
Domain	-	CKB CKM	1.34e-04	4	89	2	1.10.135.10
Domain	PHOSPHAGEN_KINASE_N	CKB CKM	1.34e-04	4	89	2	PS51509
Domain	PHOSPHAGEN_KINASE_C	CKB CKM	1.34e-04	4	89	2	PS51510
Domain	ATP-guanido_PTrfase	CKB CKM	2.22e-04	5	89	2	IPR000749
Domain	ARM-like	TNPO1 PPP2R1B PKP1 SERAC1 HEATR5A ARID1A WDFY4	3.06e-04	270	89	7	IPR011989
Domain	Gln_synth/guanido_kin_cat_dom	CKB CKM	3.33e-04	6	89	2	IPR014746
Domain	-	CKB CKM	3.33e-04	6	89	2	3.30.590.10
Domain	ANION_EXCHANGER_2	SLC4A7 SLC4A8	4.64e-04	7	89	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A7 SLC4A8	4.64e-04	7	89	2	PS00219
Domain	SWIM	ZSWIM1 ZSWIM4	4.64e-04	7	89	2	PF04434
Domain	ERAP1-like_C_dom	ERAP2 ENPEP	6.17e-04	8	89	2	IPR024571
Domain	ERAP1_C	ERAP2 ENPEP	6.17e-04	8	89	2	PF11838
Domain	Band3_cytoplasmic_dom	SLC4A7 SLC4A8	7.91e-04	9	89	2	IPR013769
Domain	Band_3_cyto	SLC4A7 SLC4A8	7.91e-04	9	89	2	PF07565
Domain	-	SLC4A7 SLC4A8	7.91e-04	9	89	2	3.40.1100.10
Domain	Znf_SWIM	ZSWIM1 ZSWIM4	7.91e-04	9	89	2	IPR007527
Domain	ZF_SWIM	ZSWIM1 ZSWIM4	7.91e-04	9	89	2	PS50966
Domain	HCO3_cotransp	SLC4A7 SLC4A8	9.86e-04	10	89	2	PF00955
Domain	HCO3_transpt_C	SLC4A7 SLC4A8	9.86e-04	10	89	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A7 SLC4A8	9.86e-04	10	89	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A7 SLC4A8	9.86e-04	10	89	2	IPR003020
Domain	Peptidase_M1	ERAP2 ENPEP	1.44e-03	12	89	2	IPR001930
Domain	WD40	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	1.49e-03	259	89	6	PF00400
Domain	Peptidase_M1	ERAP2 ENPEP	1.69e-03	13	89	2	PF01433
Domain	Peptidase_M1_N	ERAP2 ENPEP	1.69e-03	13	89	2	IPR014782
Domain	WD40	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	1.77e-03	268	89	6	SM00320
Domain	Ubiquitin-rel_dom	UBTD1 PIK3CA DVL3 PLEKHG5 USP47	1.87e-03	184	89	5	IPR029071
Domain	WD40_repeat	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	1.91e-03	272	89	6	IPR001680
Domain	uDENN	DENND4B SBF2	1.97e-03	14	89	2	SM00800
Domain	WD_REPEATS_1	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	2.13e-03	278	89	6	PS00678
Domain	WD_REPEATS_2	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	2.17e-03	279	89	6	PS50082
Domain	WD_REPEATS_REGION	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	2.17e-03	279	89	6	PS50294
Domain	uDENN	DENND4B SBF2	2.26e-03	15	89	2	PF03456
Domain	UDENN	DENND4B SBF2	2.58e-03	16	89	2	PS50946
Domain	DDENN	DENND4B SBF2	2.58e-03	16	89	2	PS50947
Domain	DENN	DENND4B SBF2	2.58e-03	16	89	2	SM00799
Domain	dDENN	DENND4B SBF2	2.58e-03	16	89	2	SM00801
Domain	DENN	DENND4B SBF2	2.58e-03	16	89	2	PF02141
Domain	dDENN_dom	DENND4B SBF2	2.58e-03	16	89	2	IPR005112
Domain	uDENN_dom	DENND4B SBF2	2.58e-03	16	89	2	IPR005113
Domain	dDENN	DENND4B SBF2	2.58e-03	16	89	2	PF03455
Domain	DENN	DENND4B SBF2	2.58e-03	16	89	2	PS50211
Domain	DENN_dom	DENND4B SBF2	2.58e-03	16	89	2	IPR001194
Domain	WD40_repeat_dom	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	2.96e-03	297	89	6	IPR017986
Domain	RhoGAP	SH3BP1 ARHGAP8 FAM13B	3.23e-03	62	89	3	SM00324
Domain	RhoGAP	SH3BP1 ARHGAP8 FAM13B	3.38e-03	63	89	3	PF00620
Domain	RHOGAP	SH3BP1 ARHGAP8 FAM13B	3.53e-03	64	89	3	PS50238
Domain	RhoGAP_dom	SH3BP1 ARHGAP8 FAM13B	3.53e-03	64	89	3	IPR000198
Domain	-	SH3BP1 ARHGAP8 FAM13B	3.53e-03	64	89	3	1.10.555.10
Domain	F-box	FBXO38 FBXW5 FBXW11	4.02e-03	67	89	3	PF00646
Domain	HEAT_REPEAT	TNPO1 PPP2R1B HEATR5A	4.55e-03	70	89	3	PS50077
Domain	FBOX	FBXO38 FBXW5 FBXW11	4.92e-03	72	89	3	PS50181
Domain	-	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	5.17e-03	333	89	6	2.130.10.10
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CKB PPP2R1B SLC4A7 NET1 PIK3CA DOCK9 SH3BP1 DVL3 CCDC187 ARHGAP8 PLEKHG5 FAM13B PHIP LRRC41	2.63e-06	720	63	14	M41838
Pathway	REACTOME_RHO_GTPASE_CYCLE	CKB SLC4A7 NET1 PIK3CA DOCK9 SH3BP1 CCDC187 ARHGAP8 PLEKHG5 FAM13B PHIP	4.27e-06	450	63	11	M27078
Pathway	REACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3	CKB PPP2R1B SLC4A7 NET1 PIK3CA DOCK9 SH3BP1 DVL3 ARHGAP8 PLEKHG5 FAM13B PHIP LRRC41	4.62e-06	649	63	13	MM15690
Pathway	REACTOME_RHO_GTPASE_CYCLE	CKB SLC4A7 NET1 PIK3CA DOCK9 SH3BP1 ARHGAP8 PLEKHG5 FAM13B PHIP	2.26e-05	439	63	10	MM15595
Pubmed	Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma.	EGFR PIK3CA	7.07e-06	2	93	2	19272638
Pubmed	Targeted sequencing of a specific gene panel detects a high frequency of ARID1A and PIK3CA mutations in ovarian clear cell carcinoma.	PIK3CA ARID1A	7.07e-06	2	93	2	30851247
Pubmed	Myocardial creatine kinase expression after left ventricular assist device support.	CKB CKM	7.07e-06	2	93	2	12039490
Pubmed	Creatine kinase transcript accumulation: effect of nerve during muscle development.	CKB CKM	7.07e-06	2	93	2	10417818
Pubmed	Phosphoinositide-3-kinase catalytic alpha and KRAS mutations are important predictors of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer.	EGFR PIK3CA	7.07e-06	2	93	2	21258250
Pubmed	Creatine kinase activity in normal and Duchenne muscular dystrophy fibroblasts.	CKB CKM	7.07e-06	2	93	2	7057800
Pubmed	EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma.	EGFR PIK3CA	7.07e-06	2	93	2	27020207
Pubmed	Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response.	EGFR PIK3CA	7.07e-06	2	93	2	22662165
Pubmed	B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity.	CD19 BTLA	7.07e-06	2	93	2	27412504
Pubmed	PIK3CA mutations and specific treatment: do not forget lessons from RAS mutations and EGFR targeting.	EGFR PIK3CA	7.07e-06	2	93	2	31970497
Pubmed	The effects of prior calcium channel blocker therapy on creatine kinase-MB levels after percutaneous coronary interventions.	CKB CKM	7.07e-06	2	93	2	19337554
Pubmed	High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers.	EGFR PIK3CA	7.07e-06	2	93	2	26680641
Pubmed	Dissimilarity in the folding of human cytosolic creatine kinase isoenzymes.	CKB CKM	7.07e-06	2	93	2	21931810
Pubmed	Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3).	EGFR EHD3	7.07e-06	2	93	2	27811356
Pubmed	Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC.	EGFR PIK3CA	7.07e-06	2	93	2	28446642
Pubmed	Expression and significance of EBV, ARID1A and PIK3CA in gastric carcinoma.	PIK3CA ARID1A	7.07e-06	2	93	2	30747208
Pubmed	The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.	EGFR PIK3CA	7.07e-06	2	93	2	27317099
Pubmed	Subunit conformation and dynamics in a heterodimeric protein: studies of the hybrid isozyme of creatine kinase.	CKB CKM	7.07e-06	2	93	2	9748661
Pubmed	Exploring the role of the active site cysteine in human muscle creatine kinase.	CKB CKM	7.07e-06	2	93	2	16981706
Pubmed	Creatine kinase in non-muscle tissues and cells.	CKB CKM	7.07e-06	2	93	2	7808454
Pubmed	Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells.	CKB CKM	7.07e-06	2	93	2	7808458
Pubmed	A patient with metastatic lung adenocarcinoma harboring concurrent EGFR L858R, EGFR germline T790M, and PIK3CA mutations: the challenge of interpreting results of comprehensive mutational testing in lung cancer.	EGFR PIK3CA	7.07e-06	2	93	2	24453288
Pubmed	Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.	PIK3CA ARID1A	7.07e-06	2	93	2	22157930
Pubmed	Genetic mutation screen in early non--small-cell lung cancer (NSCLC) specimens.	EGFR PIK3CA	7.07e-06	2	93	2	24370118
Pubmed	Diagnostic significance of total creatine kinase and its isoform in tubal ectopic pregnancy.	CKB CKM	7.07e-06	2	93	2	23876027
Pubmed	Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas.	EGFR PIK3CA	7.07e-06	2	93	2	26334752
Pubmed	Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer.	PIK3CA ARID1A	7.07e-06	2	93	2	38017109
Pubmed	UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling.	UBTD1 EGFR	7.07e-06	2	93	2	33884955
Pubmed	ALCAM-EGFR interaction regulates myelomagenesis.	EGFR ALCAM	7.07e-06	2	93	2	34592762
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	FBXO38 KLHL9 FBXW5 FBXW11	8.52e-06	48	93	4	33504946
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PPP2R1B KLHL9 EGFR RTEL1 SBF2 MACROD1 CEP192 ALCAM ZSWIM1 ZSWIM4 ARID1A ARHGAP8 LRRC41 FBXW11 EHD3	9.36e-06	1489	93	15	28611215
Pubmed	Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.	CNNM2 ST7L ENPEP	1.01e-05	16	93	3	21572416
Pubmed	Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer.	EGFR PIK3CA	2.12e-05	3	93	2	23136247
Pubmed	Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.	EGFR PIK3CA	2.12e-05	3	93	2	25953087
Pubmed	EGFR, PIK3CA and PTEN gene status and their protein product expression in neuroblastic tumours.	EGFR PIK3CA	2.12e-05	3	93	2	21225506
Pubmed	Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.	PIK3CA ARID1A	2.12e-05	3	93	2	23702729
Pubmed	Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.	SLC4A7 SLC4A8	2.12e-05	3	93	2	14736710
Pubmed	Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance.	CKB CKM	2.12e-05	3	93	2	20588136
Pubmed	Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model.	EGFR PIK3CA	2.12e-05	3	93	2	24964744
Pubmed	ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.	PIK3CA ARID1A	2.12e-05	3	93	2	31391455
Pubmed	Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling.	EGFR PIK3CA	2.12e-05	3	93	2	21780115
Pubmed	Blocking the PI3K/AKT and MEK/ERK signaling pathways can overcome gefitinib-resistance in non-small cell lung cancer cell lines.	EGFR PIK3CA	2.12e-05	3	93	2	22037177
Pubmed	Survival prediction model for non-small cell lung cancer based on somatic mutations.	EGFR PIK3CA	2.12e-05	3	93	2	32367667
Pubmed	Gene mutations in squamous cell NSCLC: insignificance of EGFR, KRAS and PIK3CA mutations in prediction of EGFR-TKI treatment efficacy.	EGFR PIK3CA	2.12e-05	3	93	2	23564819
Pubmed	[Involvement of EGF receptor and PI3K in ICAM-1 expression in human airway epithelial cells exposed to zinc sulfate].	EGFR PIK3CA	2.12e-05	3	93	2	19069650
Pubmed	Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer.	PIK3CA ARID1A	2.12e-05	3	93	2	27681437
Pubmed	SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR.	EGFR SGCE	2.12e-05	3	93	2	32714745
Pubmed	Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.	CD19 ALCAM	2.12e-05	3	93	2	31723036
Pubmed	TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.	TNPO1 ARID1A	2.12e-05	3	93	2	34044070
Pubmed	Interaction between the epidermal growth factor receptor and phosphoinositide kinases.	EGFR PIK3CA	2.12e-05	3	93	2	1845983
Pubmed	DNA Methylation Profiles of Ovarian Clear Cell Carcinoma.	PIK3CA ARID1A	2.12e-05	3	93	2	34697060
Pubmed	Clinicopathologic Significance of HNF-1β, AIRD1A, and PIK3CA Expression in Ovarian Clear Cell Carcinoma: A Tissue Microarray Study of 130 Cases.	PIK3CA ARID1A	2.12e-05	3	93	2	26945423
Pubmed	Analysis of EGFR, KRAS, and PIK3CA gene mutation rates and clinical distribution in patients with different types of lung cancer.	EGFR PIK3CA	2.12e-05	3	93	2	34217313
Pubmed	Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma.	EGFR PIK3CA	2.12e-05	3	93	2	23392229
Pubmed	The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.	SLC4A7 SLC4A8	2.12e-05	3	93	2	12444018
Pubmed	Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.	CKB CKM	2.12e-05	3	93	2	28806770
Pubmed	Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.	EGFR PIK3CA	2.12e-05	3	93	2	30590030
Pubmed	Dysferlin and myoferlin regulate transverse tubule formation and glycerol sensitivity.	CKM MYOF	2.12e-05	3	93	2	24177035
Pubmed	Esculetin Induces Apoptosis Through EGFR/PI3K/Akt Signaling Pathway and Nucleophosmin Relocalization.	EGFR PIK3CA	4.23e-05	4	93	2	26447856
Pubmed	Mutational status of EGFR, BRAF, PI3KCA and JAK2 genes in endocrine tumors.	EGFR PIK3CA	4.23e-05	4	93	2	19003996
Pubmed	Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.	PIK3CA ARID1A	4.23e-05	4	93	2	25625625
Pubmed	Amplification of CCND1, EMS1, PIK3CA, and ERBB oncogenes in ethmoid sinus adenocarcinomas.	EGFR PIK3CA	4.23e-05	4	93	2	16815198
Pubmed	Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling.	EGFR PIK3CA	4.23e-05	4	93	2	22135231
Pubmed	EGFR, KRAS, BRAF, and PIK3CA characterization in squamous cell anal cancer.	EGFR PIK3CA	4.23e-05	4	93	2	24122611
Pubmed	Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.	PIK3CA ARID1A	4.23e-05	4	93	2	26334097
Pubmed	cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer.	EGFR PIK3CA	4.23e-05	4	93	2	20959404
Pubmed	Oncogenic mutations in gastric cancer with microsatellite instability.	EGFR PIK3CA	4.23e-05	4	93	2	20937558
Pubmed	SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.	EGFR PIK3CA	4.23e-05	4	93	2	22649008
Pubmed	The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.	SLC4A7 SLC4A8	4.23e-05	4	93	2	12403779
Pubmed	ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway.	EGFR PIK3CA	4.23e-05	4	93	2	23625205
Pubmed	Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival.	PIK3CA ARID1A	4.23e-05	4	93	2	26279473
Pubmed	Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.	SLC4A7 SLC4A8	4.23e-05	4	93	2	17715183
Pubmed	Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.	EGFR PIK3CA	4.23e-05	4	93	2	19826477
Pubmed	Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with non-small cell lung cancer.	EGFR PIK3CA	4.23e-05	4	93	2	22430133
Pubmed	Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma.	PIK3CA ARID1A	4.23e-05	4	93	2	26138514
Pubmed	Mutations affecting BRAF, EGFR, PIK3CA, and KRAS are not associated with sporadic vestibular schwannomas.	EGFR PIK3CA	4.23e-05	4	93	2	23224067
Pubmed	Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations.	EGFR PIK3CA	4.23e-05	4	93	2	26670666
Pubmed	Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.	EGFR PIK3CA	4.23e-05	4	93	2	21408138
Pubmed	Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP.	CKB CKM	4.23e-05	4	93	2	25141318
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	TNPO1 SLC4A7 PIK3CA SPCS2 MACROD1 TRMT1 VARS2 EXOC3L2 HCCS SLC26A6 MSTO1 LRRC41 LCMT1	5.22e-05	1327	93	13	32694731
Pubmed	Genomic profiling in a homogeneous molecular subtype of non-small cell lung cancer: An effort to explore new drug targets.	EGFR PIK3CA	7.04e-05	5	93	2	26853422
Pubmed	Defining the interactions between intermediate filaments and desmosomes.	DSC1 PKP1	7.04e-05	5	93	2	9606214
Pubmed	Targeted Exome Sequencing of the Cancer Genome in Patients with Very High-risk Bladder Cancer.	PIK3CA ARID1A	7.04e-05	5	93	2	27520487
Pubmed	Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002.	EGFR PIK3CA	7.04e-05	5	93	2	25013125
Pubmed	Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention.	EGFR PIK3CA	7.04e-05	5	93	2	25051360
Pubmed	Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas.	EGFR PIK3CA	7.04e-05	5	93	2	20495538
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A7 SLC4A8	7.04e-05	5	93	2	23500099
Pubmed	Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.	CD19 BTLA	7.04e-05	5	93	2	35320716
Pubmed	EGFR and downstream genetic alterations in KRAS/BRAF and PI3K/AKT pathways in colorectal cancer: implications for targeted therapy.	EGFR PIK3CA	7.04e-05	5	93	2	23021375
Pubmed	Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase.	CKB CKM	7.04e-05	5	93	2	2914937
Pubmed	The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners.	DSC1 PKP1	7.04e-05	5	93	2	19136012
Pubmed	Developmental regulation of creatine kinase gene expression by myogenic factors in embryonic mouse and chick skeletal muscle.	CKB CKM	7.04e-05	5	93	2	1668275
Pubmed	Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.	EGFR PIK3CA	7.04e-05	5	93	2	16397024
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CKB FBXO38 PPP2R1B KLHL9 DSC1 NET1 FBXW5 PKP1 CEP192 USP47 FBXW11	7.81e-05	1005	93	11	19615732
Pubmed	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.	EGFR PIK3CA	1.05e-04	6	93	2	10648629
Pubmed	The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.	USP47 FBXW11	1.05e-04	6	93	2	19966869
Pubmed	Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.	EGFR PIK3CA	1.47e-04	7	93	2	17487277
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	EGFR PIK3CA	1.47e-04	7	93	2	8561895
Pubmed	ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.	CD19 ARID1A	1.47e-04	7	93	2	38458187
Pubmed	Creatine and creatinine metabolism.	CKB CKM	1.47e-04	7	93	2	10893433
GeneFamily	WD repeat domain containing	CORO2A FBXW5 TLE6 WDFY4 PHIP FBXW11	2.07e-04	262	59	6	362
GeneFamily	Zinc fingers SWIM-type\|Mitogen-activated protein kinase kinase kinases	ZSWIM1 ZSWIM4	3.71e-04	9	59	2	90
GeneFamily	Immunoglobulin like domain containing	IL1RAPL1 CD19 BTLA ALCAM SDK1	4.13e-04	193	59	5	594
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW5 FBXW11	5.65e-04	11	59	2	559
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	SH3BP1 ARHGAP8 FAM13B	5.80e-04	50	59	3	721
GeneFamily	Aminopeptidases\|CD molecules	ERAP2 ENPEP	1.38e-03	17	59	2	104
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4B SBF2	2.99e-03	25	59	2	504
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 DOCK9 SBF2 PLEKHG5	4.57e-03	206	59	4	682
GeneFamily	Kelch like\|BTB domain containing	KLHL9 KLHL33	8.29e-03	42	59	2	617
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CORO2A BTLA ALCAM WDFY4 SLC26A6	1.09e-06	160	93	6	5c28121916a12dbc22ef2421040bdc9148a40b78
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CORO2A BTLA ALCAM WDFY4 SLC26A6	1.09e-06	160	93	6	b7093678987575f2f99d648821d31b4a37075aca
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CKB CORO2A SH3BP1 BTLA ALCAM WDFY4	3.13e-06	192	93	6	8b4bbbadeac70f65378697120c754f10501b5651
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Plasma_cells\|normal_Pleural_Fluid / Location, Cell class and cell subclass	ASB3 JMJD4 SERAC1 ALCAM HMCES	8.51e-06	132	93	5	4e37400ae7375e6986f060234c373194603346f8
ToppCell	PND07-Immune-Immune_Myeloid-DC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC4A8 CORO2A SH3BP1 BTLA WDFY4	1.43e-05	147	93	5	bbc52cbea37a38058436e3fc6fc0777f83404524
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	ASB3 JMJD4 SERAC1 ALCAM HMCES	1.74e-05	153	93	5	a156710217ef07c07a80ca6504fa0784d86380fa
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ALKBH4 MACROD1 BTLA VARS2	2.06e-05	77	93	4	ebb1a537751739232820a60f88911877fc683855
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CORO2A DENND4B BTLA WDFY4	2.29e-05	162	93	5	388670cf3acef17df971c0d8ae3ce14398945192
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CORO2A DENND4B BTLA WDFY4	2.29e-05	162	93	5	9333d923225df7bfdf6b3a4c32816751315aec50
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CORO2A SH3BP1 BTLA WDFY4	2.43e-05	164	93	5	90404b3b6b6a9b88a75cba09baa94c718e577c44
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKB CORO2A SH3BP1 BTLA WDFY4	2.43e-05	164	93	5	662f74ad2656c0af158dbf9eb81d5bf70f54e529
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_C\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CKB MYO15B CEP192 MSTO1	2.64e-05	82	93	4	32ab4ee9c39b976b1ddf68864a256a0e942327ff
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EGFR CORO2A PKP1 GSDMC SDK1	2.73e-05	168	93	5	6521bead9789d626b86cbd08692c621c5a5aef33
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EGFR CORO2A PKP1 GSDMC SDK1	2.80e-05	169	93	5	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	droplet-Pancreas-Endocrine-21m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD19 SH3BP1 BTLA WDFY4 TESPA1	2.88e-05	170	93	5	6086d658a52a1961a1e293cbc3703ae8d309cd11
ToppCell	droplet-Lung-nan-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CORO2A BTLA ALCAM WDFY4	2.97e-05	171	93	5	06fe7eeffc6e0735342b88e1d1ae26a9b477fece
ToppCell	droplet-Lung-LUNG-30m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD19 BTLA KLHL33 WDFY4 TG	3.22e-05	174	93	5	28ec25767bbd4fd898738f9f4d2b585dc91b5adf
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CKB MYO15B CD19 ST7L SLC26A6	3.31e-05	175	93	5	87e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCell	COVID-mDC1-\|COVID / Condition, Cell_class and T cell subcluster	CKB NET1 NUTM2D BTLA WDFY4	3.31e-05	175	93	5	83a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCell	COVID-mDC1\|COVID / Condition, Cell_class and T cell subcluster	CKB NET1 NUTM2D BTLA WDFY4	3.31e-05	175	93	5	b9280444016e21c28131a61df65cc5c56d402412
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	PPP2R1B STOX2 KLHL9 DOCK9 MBD1	3.40e-05	176	93	5	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	facs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CORO2A SH3BP1 BTLA WDFY4	3.50e-05	177	93	5	7bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCell	facs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB CORO2A SH3BP1 BTLA WDFY4	3.50e-05	177	93	5	3cb96d7d56c9ff90f1f8a6caaf49e580e2524c7d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A DENND4B BTLA WDFY4 TESPA1	3.59e-05	178	93	5	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALKBH4 SH3BP1 BTLA TESPA1 GASK1B	3.59e-05	178	93	5	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A DENND4B BTLA WDFY4 TESPA1	3.59e-05	178	93	5	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CORO2A DENND4B BTLA WDFY4 TESPA1	3.59e-05	178	93	5	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	droplet-Limb_Muscle-nan-18m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD19 BTLA WDFY4 TESPA1 TG	3.59e-05	178	93	5	4523da0901b78cea5654c1d78c65363455e4f745
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD19 BTLA WDFY4 TESPA1 TG	3.79e-05	180	93	5	c12c1cc206f7e63e5722471bd3eb84caddb84129
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD19 BTLA WDFY4 TESPA1 TG	3.79e-05	180	93	5	d8135f73a89b97168f2048258f4648e23536ece4
ToppCell	droplet-Fat-Mat-18m-Lymphocytic-B_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD19 BTLA WDFY4 TESPA1 TG	4.32e-05	185	93	5	98bb853c495eb16c3663685a8e20755bd309b520
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	STOX2 DOCK9 ALCAM ARHGAP8 SDK1	4.32e-05	185	93	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKM KY FBXW5 VARS2 MSTO1	4.66e-05	188	93	5	40ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKM KY FBXW5 VARS2 MSTO1	4.66e-05	188	93	5	ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYOF KLHL9 NET1 COLGALT1 WDFY4	4.78e-05	189	93	5	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYOF SLC4A7 PHACTR3 SGCE ALCAM	4.78e-05	189	93	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	facs-Marrow-KLS-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CKB SLC4A8 ABCB8 SH3BP1 COLGALT1	4.90e-05	190	93	5	c03c735a0ed850bf460a1847f5e2dd61753e577d
ToppCell	B_cells-Activate_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CD19 BTLA WDFY4 EHD3 NUAK2	5.28e-05	193	93	5	b6da81920cf2e55f87ec8d4b2b5530cbf7ba2155
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CKB CKM KY PHACTR3 MACROD1	5.54e-05	195	93	5	80b973d2a23ef9b101c90e1635e68c9a3f78f65d
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MYOF FBXW5 COLGALT1 EXOC3L2 GASK1B	5.82e-05	197	93	5	ec92d60f802c9d4bdf9877bed5c0a91a5a5ed5d0
ToppCell	343B-Endothelial_cells-Endothelial-A_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MYOF FBXW5 COLGALT1 EXOC3L2 GASK1B	5.82e-05	197	93	5	7bec9c1bc8851064eb229324493b47a31201c83c
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYOF NET1 EGFR PKP1 SDK1	5.96e-05	198	93	5	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CKM MYO15B DSC1 COLGALT1 WDFY4	5.96e-05	198	93	5	732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYOF EGFR PKP1 GSDMC SDK1	5.96e-05	198	93	5	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYOF EGFR PKP1 GSDMC SDK1	6.10e-05	199	93	5	94a7867e800df352731796de8c24cba133c29622
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYOF NET1 EGFR PKP1 ALCAM	6.25e-05	200	93	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYOF NET1 EGFR PKP1 ALCAM	6.25e-05	200	93	5	ecbe89ff95d046155b984c8c150e0b9e7278f839
Drug	thallium	CKB CKM AOC2 TG	2.83e-06	25	91	4	CID000105005
Drug	Dithallium chromate	CKB CKM AOC2 TG	5.25e-06	29	91	4	CID000061626
Drug	stannous pyrophosphate	CKB CKM AOC2	9.96e-06	11	91	3	CID000066379
Drug	Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; HL60; HG-U133A	ALKBH4 MYOF CNNM2 SLC4A7 RTEL1 MBD1 ARID1A	1.34e-05	195	91	7	1573_UP
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	UBTD1 CNNM2 SLC4A7 DVL3 ALCAM ENPEP LRRC41	1.38e-05	196	91	7	4408_DN
Disease	Lung cancer	PPP2R1B EGFR PIK3CA	9.75e-06	14	90	3	cv:C0242379
Disease	LUNG CANCER	PPP2R1B EGFR PIK3CA	9.75e-06	14	90	3	211980
Disease	Neoplasm of lung	PPP2R1B EGFR PIK3CA	9.75e-06	14	90	3	cv:C0024121
Disease	age at onset, glioblastoma multiforme	EGFR RTEL1	2.55e-04	8	90	2	EFO_0000519, EFO_0004847
Disease	breast carcinoma	PPP2R1B SLC4A7 EGFR SBF2 MBD1 CCDC87 SGCE CEP192 ALCAM PHIP MSTO1	2.72e-04	1019	90	11	EFO_0000305
Disease	glioblastoma multiforme	EGFR RTEL1	3.27e-04	9	90	2	EFO_0000519
Disease	Head and Neck Carcinoma	EGFR PIK3CA	4.07e-04	10	90	2	C3887461
Disease	Carcinoma, Granular Cell	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0205644
Disease	Adenocarcinoma, Tubular	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0205642
Disease	Carcinoma, Cribriform	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0205643
Disease	Adenocarcinoma, Basal Cell	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0205641
Disease	Adenocarcinoma	CKB EGFR PIK3CA ARID1A	4.47e-04	116	90	4	C0001418
Disease	Small cell carcinoma of lung	CKB EGFR GRIK3	6.08e-04	54	90	3	C0149925
Disease	mean reticulocyte volume	TNPO1 FBXO38 PPP2R1B PIK3CA MBD1 ASB3 DNAH2 MACROD1 EXOC3L2	7.48e-04	799	90	9	EFO_0010701
Disease	Adenocarcinoma Of Esophagus	PIK3CA ARID1A	8.17e-04	14	90	2	C0279628
Disease	central nervous system cancer, glioblastoma multiforme	EGFR RTEL1	8.17e-04	14	90	2	EFO_0000326, EFO_0000519
Disease	anemia (implicated_via_orthology)	SLC4A7 SLC4A8	9.41e-04	15	90	2	DOID:2355 (implicated_via_orthology)
Disease	granulysin measurement	ERAP2 FBXW5	9.41e-04	15	90	2	EFO_0008144
Disease	white matter lesion progression measurement	CNNM2 SLC4A8 GLE1	1.35e-03	71	90	3	EFO_0007746
Disease	lung cancer (is_implicated_in)	RTEL1 MBD1 DVL3	1.52e-03	74	90	3	DOID:1324 (is_implicated_in)
Disease	metabolite measurement	MYOF ABCB8 UGT2B10 ALCAM ZSWIM1 WDFY4 ENPEP	1.64e-03	560	90	7	EFO_0004725
Disease	pancreatic carcinoma	CKB SBF2 ASB3 ST7L	2.01e-03	174	90	4	EFO_0002618
Disease	Nasopharyngeal carcinoma	PIK3CA ARID1A	2.04e-03	22	90	2	C2931822
Disease	glioma	EGFR RTEL1	2.04e-03	22	90	2	EFO_0005543
Disease	platelet component distribution width	CKB SLC4A7 EGFR DOCK9 PHACTR3 EXOC3L2 ST7L EHD3	2.17e-03	755	90	8	EFO_0007984
Disease	Carcinoma of lung	EGFR PIK3CA	2.23e-03	23	90	2	C0684249
Disease	Glioma	EGFR RTEL1 PIK3CA	2.42e-03	87	90	3	C0017638
Disease	Intrahepatic Cholangiocarcinoma	EGFR ARID1A	2.43e-03	24	90	2	C0345905
Disease	aspartate measurement	GRIK3 ENPEP	2.43e-03	24	90	2	EFO_0010462
Disease	Extrahepatic Cholangiocarcinoma	EGFR ARID1A	2.43e-03	24	90	2	C3805278
Disease	platelet crit	TNPO1 SLC4A7 EGFR RTEL1 FBXW5 ST7L ARID1A FAM13B EHD3	2.50e-03	952	90	9	EFO_0007985
Disease	Left Ventricular Hypertrophy	CKB CKM	2.64e-03	25	90	2	C0149721
Disease	Cholangiocarcinoma	EGFR ARID1A	2.85e-03	26	90	2	C0206698

Protein segments in the cluster

Peptide	Gene	Start	Entry
VMPTLRQAAEDKSWR	PPP2R1B	256	P30154
AELVRLMDRDPWKLS	ALKBH4	86	Q9NXW9
LMDRDPWKLSQSGRR	ALKBH4	91	Q9NXW9
LMRRKWLSSPEALDG	EXOC3L2	186	Q2M3D2
SPWAMTERKHSSLER	CCDC187	426	A0A096LP49
RPRSIWRAKATLDMP	C8orf33	206	Q9H7E9
WRAKATLDMPDEEFR	C8orf33	211	Q9H7E9
ERPSKDEMASRPWLL	BTLA	141	Q7Z6A9
RSTWDVEAKMPLSAL	GSDMC	481	Q9BYG8
DDWMRAASLKEPGAR	SH3BP1	366	Q9Y3L3
SMLAEEWKRPLGRRA	CALHM1	76	Q8IU99
MPSEGRCWETLKALR	GLE1	1	Q53GS7
RPALDSLSAVWDRMK	HCCS	246	P53701
SMPSLREGWRLADEL	CCDC87	311	Q9NVE4
SPESGLEVRDRMWLK	DVL3	421	Q92997
TPAKRRSSALWSEML	NET1	146	Q7Z628
RRRLTMKDIGTPEAW	ARID1A	1656	O14497
IPLESDMERALSWGR	AOC2	611	O75106
MAEAPGLERLWSKAR	KLHL33	81	A6NCF5
LLLASGMARDWPDAR	CKB	201	P12277
KTAMDLAAEQLRLWP	SBF2	711	Q86WG5
LAMERPAATTSRWLL	CRB2	961	Q5IJ48
PWDRSSLKSMSLDLQ	KY	136	Q8NBH2
SRAASMPELLEQLWK	FAM13B	836	Q9NYF5
LDRERAWKLEAFSRM	CCNYL2	316	Q5T2Q4
AMKRLLPSVWSESED	MBD1	381	Q9UIS9
DDATIKAWRSPRTMR	FBXW5	531	Q969U6
RLIREMEAWAAFPAR	PNMA6E	486	A0A0J9YXQ4
MSKEEDSIWFRPTLL	IL1RAPL1	96	Q9NZN1
DLTKLDLRRWASFMD	MSTO1	526	Q9BUK6
MVRTDPLWKGLSERR	FBXW11	171	Q9UKB1
FKAACRWLRLEDPRM	KLHL9	216	Q9P2J3
ASRLPVKEVMDTWTR	ENPEP	526	Q07075
LEECRIMSSAKRPLW	PIK3CA	766	P42336
LMWSQPDDRLRKSGV	PABPC5	91	Q96DU9
PGLARWDRASEVRKM	MYO15B	1506	Q96JP2
MISDFPWLRSLRAAE	FBXO38	1101	Q6PIJ6
SAPSWLSKDDIRRMR	GASK1B	211	Q6UWH4
WMIDADSRPKFRELI	EGFR	951	P00533
WKTLAPAVERMLSAR	ASB3	431	Q9Y575
PAVERMLSARASNAW	ASB3	436	Q9Y575
SPMARAEKSRTAWTD	HEATR5A	1786	Q86XA9
PELRKTWLDSMARIH	DOCK9	1611	Q9BZ29
LSLELKDDRPARDMW	CD19	226	P15391
AWRISTAPLRAMFKD	DCST1	161	Q5T197
RPVLSWMDRETRALA	JMJD4	41	Q9H9V9
SSSLLEEKMPRWAAE	CORO2A	441	Q92828
RTWAPLAMAAKVDLS	MACROD1	76	Q9BQ69
SRASMSDTWDLSLPK	CEP192	801	Q8TEP8
RMAQKSAAVPELWAR	DENND4B	751	O75064
RSKRRWAPIPASLME	DSC1	131	Q08554
WDRMLRSALLKLACD	ERAP2	746	Q6P179
VEKWSMERLQAAPRS	GRIK3	296	Q13003
LRQAALKSARDMWAD	COLGALT1	146	Q8NBJ5
SQKPLAAWTRDLAMR	DNAH2	4246	Q9P225
LWDMFVKDIPRSATS	SDK1	1946	Q7Z5N4
WMKDNIRLRSSPSFS	ALCAM	366	Q13740
KDADSSERIIAPMRW	HMCES	61	Q96FZ2
VMLDGRDLRTLDPSW	ABCB8	531	Q9NUT2
ARRKPTMTLEEGLWR	NUTM2D	296	Q5VT03
RRKPTMTLEEGLWRA	NUTM2G	246	Q5VZR2
RADKPWTRLSAADKA	PHACTR3	516	Q96KR7
AEAARLLLSDMWSSK	PKP1	701	Q13835
MEKSLEFWRARDLAR	RTEL1	566	Q9NZ71
SPMDAWILSRLALAA	VARS2	776	Q5ST30
SLSDWRARCPMERKS	SERAC1	456	Q96JX3
VKTDAPASALWDIMR	TRMT1	486	Q9NXH9
FTKRELSWLDDLMPE	SLC4A7	1126	Q9Y6M7
DDALRMLEVTWSSLP	TBC1D25	421	Q3MII6
LLLASGMARDWPDAR	CKM	201	P06732
MDTTFWRLKDEDLLP	LCMT1	101	Q9UIC8
LWDELMKTRPSSLES	LRRC41	106	Q15345
SDMRSLWKANRADLL	SLC26A6	461	Q9BXS9
TMDLWNHLRPRASEK	SLC5A11	401	Q8WWX8
FSKRELSWLDDLMPE	SLC4A8	996	Q2Y0W8
SMADWLRRSSRPLLE	NUAK2	331	Q9H093
MFSWLGTDDRRRKDP	EHD3	1	Q9NZN3
LRDMSKNREIAWPLS	SGCE	371	O43556
ALPTWKMAARRSLSA	CNNM2	21	Q9H8M5
RLWASVMAPVLEKAR	PLEKHG5	396	O94827
RREWKSILLDMATRP	PHIP	396	Q8WWQ0
MDPDDIWQLSSSLKR	SPCS2	151	Q15005
MTPEWDVSGELAKRR	STOX2	436	Q9P2F5
SMSQLAVLSRRWKPS	USP47	1221	Q96K76
QSSSPTALWDMLERK	WDFY4	36	Q6ZS81
FLRPSDTVMQKAWRE	ST7L	201	Q8TDW4
PMTDGQLRSKRDEFW	UBTD1	41	Q9HAC8
AVASWINPKDDLRDM	TNPO1	846	Q92973
EFDRKDGDLTMWPRL	ARHGAP8	96	P85298
RPTTLSETMRKADIW	UGT2B10	241	P36537
MEASVLSPTSWEKRR	TESPA1	1	A2RU30
MLERLKAPWSAALQR	ZSWIM1	1	Q9BR11
CPIIDMASAWAKRAR	TG	2591	P01266
EDIMATRSSDWLRRP	TLE6	121	Q9H808
APMLSDILRRWTLSA	ZSWIM4	876	Q9H7M6
MRKWLLLNDPEDTSS	MYOF	296	Q9NZM1