Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopolyphosphatase activity	NUDT4B NUDT11 NUDT4 NUDT10	1.48e-08	5	149	4	GO:0000298
GeneOntologyMolecularFunction	bis(5'-adenosyl)-hexaphosphatase activity	NUDT4B NUDT11 NUDT4 NUDT10	1.48e-08	5	149	4	GO:0034431
GeneOntologyMolecularFunction	diphosphoinositol-polyphosphate diphosphatase activity	NUDT4B NUDT11 NUDT4 NUDT10	1.48e-08	5	149	4	GO:0008486
GeneOntologyMolecularFunction	bis(5'-adenosyl)-pentaphosphatase activity	NUDT4B NUDT11 NUDT4 NUDT10	4.42e-08	6	149	4	GO:0034432
GeneOntologyMolecularFunction	pyrophosphatase activity	MYH4 ATP13A1 ENPP2 LRRK2 DNAJC27 CCT4 PPA1 NUDT4B GTPBP10 DDX27 NUDT11 NUDT4 MDN1 DDX18 AFG3L2 NUDT10 ABCC12 DHX29	5.53e-05	839	149	18	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	MYH4 ATP13A1 ENPP2 LRRK2 DNAJC27 CCT4 PPA1 NUDT4B GTPBP10 DDX27 NUDT11 NUDT4 MDN1 DDX18 AFG3L2 NUDT10 ABCC12 DHX29	5.61e-05	840	149	18	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	MYH4 ATP13A1 ENPP2 LRRK2 DNAJC27 CCT4 PPA1 NUDT4B GTPBP10 DDX27 NUDT11 NUDT4 MDN1 DDX18 AFG3L2 NUDT10 ABCC12 DHX29	5.61e-05	840	149	18	GO:0016818
GeneOntologyMolecularFunction	calmodulin binding	MYH1 MYH4 MYH13 ESRRG GRM7 PHKA1 USP6 NOS1	3.39e-04	230	149	8	GO:0005516
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) metabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901910
GeneOntologyBiologicalProcess	adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901911
GeneOntologyBiologicalProcess	diadenosine pentaphosphate catabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901907
GeneOntologyBiologicalProcess	diadenosine pentaphosphate metabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901906
GeneOntologyBiologicalProcess	diadenosine hexaphosphate catabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901909
GeneOntologyBiologicalProcess	diadenosine hexaphosphate metabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:1901908
GeneOntologyBiologicalProcess	diphosphoinositol polyphosphate metabolic process	NUDT4B NUDT11 NUDT4 NUDT10	1.27e-08	5	148	4	GO:0071543
GeneOntologyBiologicalProcess	diadenosine polyphosphate catabolic process	NUDT4B NUDT11 NUDT4 NUDT10	3.78e-08	6	148	4	GO:0015961
GeneOntologyBiologicalProcess	diadenosine polyphosphate metabolic process	NUDT4B NUDT11 NUDT4 NUDT10	3.12e-07	9	148	4	GO:0015959
GeneOntologyBiologicalProcess	inositol phosphate metabolic process	NUDT4B NUDT11 NUDT4 NUDT10 PPIP5K1	3.52e-05	52	148	5	GO:0043647
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	SPP1 ENPP2 LRRK2 ALS2 POU4F1 POU4F2 ZDHHC17 RREB1 PTK2 AFG3L2 VPS13A PLXNA4 PAK1 AFDN RIMS1 MAP4K4 UNC5D	8.37e-05	819	148	17	GO:0120039
GeneOntologyBiologicalProcess	cell projection morphogenesis	SPP1 ENPP2 LRRK2 ALS2 POU4F1 POU4F2 ZDHHC17 RREB1 PTK2 AFG3L2 VPS13A PLXNA4 PAK1 AFDN RIMS1 MAP4K4 UNC5D	9.28e-05	826	148	17	GO:0048858
GeneOntologyBiologicalProcess	Fc receptor mediated stimulatory signaling pathway	PTK2 PTPRC PAK1 PRKCD	1.12e-04	35	148	4	GO:0002431
GeneOntologyBiologicalProcess	organophosphate catabolic process	ENPP2 PLA2G4E NUDT4B NUDT11 NUDT4 NUDT10 PRKCD PNPLA7 MBD4	2.00e-04	281	148	9	GO:0046434
GeneOntologyCellularComponent	postsynapse	CARMIL3 PDYN LRRK2 ALS2 ZDHHC17 GRM7 PTK2 RPL10A USP6 KCTD16 PAK1 SENP6 PRKCD AFDN TANC1 RIMS1 NOS1 RPL7 BEGAIN	1.07e-04	1018	148	19	GO:0098794
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH4 MYH13	1.82e-04	16	148	3	GO:0005859
GeneOntologyCellularComponent	neuron to neuron synapse	PDYN ALS2 GRM7 RPL10A USP6 PLXNA4 PAK1 AFDN TANC1 RIMS1 NOS1 RPL7	3.56e-04	523	148	12	GO:0098984
GeneOntologyCellularComponent	dense core granule lumen	PDYN VPS13A	4.91e-04	5	148	2	GO:0098898
GeneOntologyCellularComponent	neuronal dense core vesicle lumen	PDYN VPS13A	4.91e-04	5	148	2	GO:0099013
GeneOntologyCellularComponent	presynapse	PDYN LRRK2 ZDHHC17 GRM7 RPL10A OSBPL2 KCTD16 GLUL SENP6 PRKCB AFDN TANC1 RIMS1 NOS1 RPL7 BEGAIN	5.55e-04	886	148	16	GO:0098793
GeneOntologyCellularComponent	asymmetric synapse	ALS2 GRM7 RPL10A USP6 PLXNA4 PAK1 AFDN TANC1 RIMS1 NOS1 RPL7	6.02e-04	477	148	11	GO:0032279
GeneOntologyCellularComponent	myosin filament	MYH1 MYH4 MYH13	7.13e-04	25	148	3	GO:0032982
GeneOntologyCellularComponent	axon terminus	PDYN LRRK2 GRM7 GLUL PRKCB TANC1 NOS1	7.56e-04	210	148	7	GO:0043679
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH4 MYH13	1.00e-03	28	148	3	GO:0016460
GeneOntologyCellularComponent	neuron projection terminus	PDYN LRRK2 GRM7 GLUL PRKCB TANC1 NOS1	1.38e-03	233	148	7	GO:0044306
Domain	NUDIX_hydrolase_CS	NUDT11 NUDT4 NUDT10	9.78e-05	12	146	3	IPR020084
Domain	AKAP95	ZNF326 AKAP8	1.81e-04	3	146	2	PF04988
Domain	AKAP95	ZNF326 AKAP8	1.81e-04	3	146	2	IPR007071
Domain	ZF_C2H2_AKAP95	ZNF326 AKAP8	1.81e-04	3	146	2	PS51799
Domain	Myosin_N	MYH1 MYH4 MYH13	1.99e-04	15	146	3	PF02736
Domain	Myosin_N	MYH1 MYH4 MYH13	1.99e-04	15	146	3	IPR004009
Domain	Myosin_tail_1	MYH1 MYH4 MYH13	3.50e-04	18	146	3	PF01576
Domain	Myosin_tail	MYH1 MYH4 MYH13	3.50e-04	18	146	3	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH4 MYH13	4.14e-04	19	146	3	IPR027401
Domain	-	MYH1 MYH4 MYH13	4.14e-04	19	146	3	4.10.270.10
Domain	DAG/PE-bd	RAF1 PRKCB PRKCD	5.61e-04	21	146	3	IPR020454
Domain	Autophagy-rel_C	ATG2A VPS13A	5.98e-04	5	146	2	IPR015412
Domain	ATG_C	ATG2A VPS13A	5.98e-04	5	146	2	PF09333
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT4 NUDT10 PPIP5K1	5.67e-07	10	104	4	MM14709
Pathway	REACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL	NUDT11 NUDT4 NUDT10 PPIP5K1	5.67e-07	10	104	4	M27051
Pathway	KEGG_TIGHT_JUNCTION	MYH1 MYH4 MYH13 CLDN16 PRKCB PRKCD AFDN	5.38e-05	132	104	7	M11355
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	RAF1 PLA2G4E PTPRC PAK1 PRKCB PRKCD	7.56e-05	96	104	6	M16121
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 FAT4 ZNF326 AKAP8 MYH13 EFCAB6 GPATCH1 CNTRL LRRK2 NUP98 CCT4 PKHD1L1 KIAA1671 OSBPL2 DDX18 EIF2B4 VPS13A AFDN RPL7	1.11e-09	777	149	19	35844135
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ZNF326 ATP13A1 NUP98 KRI1 CCT4 PPA1 DDX27 GTF3C5 DNTTIP2 RPL10A TTLL12 TMX1 PBRM1 NUDT4 MDN1 DDX18 KCTD16 GLUL PRKCD AFDN TAF5L MAP4K4 DHX29 RPL7	9.90e-09	1425	149	24	30948266
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ZHX3 AKAP8 NUP98 RREB1 TMX1 MDN1 PTPRC XPO6 RBM6 SENP6 PRKCD AFDN RIMS1 KAT6B MAP4K4 DHX29 UNC5D	4.21e-08	774	149	17	15302935
Pubmed	Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.	NUDT11 NUDT4 NUDT10	7.71e-08	3	149	3	12121577
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ERO1B AKAP8 ATP13A1 TEX2 PIEZO1 KRI1 DNAJC27 ZDHHC17 NDUFB8 DDX27 DNTTIP2 RPL10A TTLL12 TMX1 MDN1 DDX18 EIF2B4 AFG3L2 VPS13A TANC1 MAP4K4 DHX29 RPL7	9.74e-08	1487	149	23	33957083
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	RAF1 USP34 ZNF326 AKAP8 GPX8 PSMB7 NUP98 KRI1 PTPN23 CCT4 DDX27 RPL10A TMX1 EIF2B4 AFG3L2 GLUL AFDN DHX29	2.16e-07	974	149	18	28675297
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH4 MYH13	3.07e-07	4	149	3	10388558
Pubmed	Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.	NUDT11 NUDT4 NUDT10	3.07e-07	4	149	3	12370170
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MDN1 XPO6 PPIP5K1 ZFYVE26 RIMS1 KAT6B CABIN1	3.45e-07	104	149	7	9205841
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ZNF326 AKAP8 KRI1 GTPBP10 DDX27 GTF3C5 DNTTIP2 RPL10A PBRM1 MDN1 DDX18 EIF2B4 RBM6 DHX29 RPL7	1.04e-06	759	149	15	35915203
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ZNF326 GPX8 PTPN23 CCT4 PPA1 ARMCX1 DDX27 GTF3C5 PTK2 DNTTIP2 RPL10A MDN1 DDX18 EIF2B4 AFG3L2 PRKCD AFDN TANC1 DHX29 RPL7	1.46e-06	1353	149	20	29467282
Pubmed	Runx1 expression defines a subpopulation of displaced amacrine cells in the developing mouse retina.	POU4F1 POU4F2 GLUL NOS1	1.49e-06	20	149	4	16026391
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH4 MYH13	1.53e-06	6	149	3	10077619
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	ERO1B GPX8 ATP13A1 TEX2 RAB11FIP2 NUP98 ZDHHC17 DNTTIP2 RPL10A KIAA1671 TMX1 NUDT11 NUDT4 EIF4ENIF1 GLUL RBM6 ZNF830	1.65e-06	1007	149	17	34597346
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	RAF1 TEX2 PSMB7 NUP98 COX11 CCT4 ZDHHC17 GTPBP10 NDUFB8 DDX27 RPL10A KIAA1671 TMX1 MDN1 EIF4ENIF1 DDX18 AFG3L2 VPS13A PRKCD TANC1 RPL7	1.76e-06	1496	149	21	32877691
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	GRM7 KCTD16 AFG3L2 TM7SF2 AFDN TANC1 NOS1 BEGAIN	2.31e-06	197	149	8	36604605
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH4 MYH13	2.66e-06	7	149	3	35210422
Pubmed	14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells.	RAF1 PRKCB PRKCD	2.66e-06	7	149	3	10433554
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	C14orf93 ZNF326 AKAP8 GPATCH1 NUP98 RREB1 ARHGAP11A WDR76 GTF3C5 DNTTIP2 RPL10A PBRM1 MDN1 DDX18 AFG3L2 TAF5L MBD4 CABIN1 RPL7	3.01e-06	1294	149	19	30804502
Pubmed	A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.	USP34 ATXN7L1 CNTRL RPL10A EFHC1 NUDT11 KCTD16 NUDT10	3.11e-06	205	149	8	12040188
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	AKAP8 MSANTD2 CCT4 PTK2 PBRM1 MDN1 KCTD16 GLUL PAK1 PRKCB AFDN RIMS1 CABIN1 MAP4K4 NOS1 BEGAIN	4.16e-06	963	149	16	28671696
Pubmed	Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons.	PDYN POU4F1 POU4F2	4.25e-06	8	149	3	37733805
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ZNF326 GPATCH1 CNTRL PKD1L1 KRI1 PTPN23 CCT4 ATG2A DDX27 KIAA1671 EIF4ENIF1 AFDN TANC1 MAP4K4 RPL7	4.30e-06	853	149	15	28718761
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 NUP98 KRI1 DDX27 DNTTIP2 RPL10A TTLL12 PBRM1 MDN1 DDX18 RBM6 AFDN RPL7	5.19e-06	653	149	13	22586326
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	ATP13A1 GPATCH1 NUP98 DDX27 RPL10A MDN1 OSBPL2 EIF2B4 AFDN DHX29	5.45e-06	375	149	10	32788342
Pubmed	Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2.	RAF1 PRKCB PRKCD	6.35e-06	9	149	3	14654844
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZNF326 AKAP8 NUP98 CCT4 DDX27 GTF3C5 DNTTIP2 RPL10A KIAA1671 PBRM1 MDN1 DDX18 AFG3L2 AFDN MAP4K4 RPL7	8.97e-06	1024	149	16	24711643
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	USP34 FAT4 NUDT11 EIF4ENIF1 NUDT10 PAK1 ZNF830 MAP4K4	1.18e-05	246	149	8	15345747
Pubmed	Human transcription factor protein interaction networks.	ZHX3 ZNF326 AKAP8 ATXN7L1 PSMB7 NUP98 MSANTD2 KRI1 CCT4 RREB1 DDX27 RPL10A KIAA1671 PBRM1 EIF4ENIF1 DDX18 RBM6 TAF5L CABIN1	1.23e-05	1429	149	19	35140242
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	USP34 MYH4 GPX8 ESRRG PPA1 DNTTIP2 ZNF587B KCNH3 KIAA1671 EFHC1 ATOH8 KCTD16 MTTP ZFYVE26	1.49e-05	832	149	14	36724073
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	KRI1 CCT4 PPA1 DDX27 RPL10A KIAA1671 TMX1 MDN1 DDX18 EIF2B4 TAF5L RPL7	1.71e-05	624	149	12	33729478
Pubmed	Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+.	RAF1 PRKCD	1.82e-05	2	149	2	11171046
Pubmed	Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding.	POU4F1 POU4F2	1.82e-05	2	149	2	8537352
Pubmed	Brn3 transcription factors control terminal osteoclastogenesis.	POU4F1 POU4F2	1.82e-05	2	149	2	17668438
Pubmed	Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP.	PTPN23 PTK2	1.82e-05	2	149	2	18835089
Pubmed	Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.	PRKCB PRKCD	1.82e-05	2	149	2	16950644
Pubmed	Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.	ZAP70 PRKCB	1.82e-05	2	149	2	19907441
Pubmed	Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor.	POU4F1 POU4F2	1.82e-05	2	149	2	8995448
Pubmed	Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.	RAF1 PAK1	1.82e-05	2	149	2	9234708
Pubmed	Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.	NUDT11 NUDT10	1.82e-05	2	149	2	12689335
Pubmed	Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells.	PAK1 PRKCD	1.82e-05	2	149	2	16033904
Pubmed	Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.	POU4F1 POU4F2	1.82e-05	2	149	2	8234287
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	1.82e-05	2	149	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	1.82e-05	2	149	2	11150240
Pubmed	Role of PKCbetaII and PKCdelta in blood-brain barrier permeability during aglycemic hypoxia.	PRKCB PRKCD	1.82e-05	2	149	2	19900507
Pubmed	Protein kinase C (PKC) isoforms in cancer, tumor promotion and tumor suppression.	PRKCB PRKCD	1.82e-05	2	149	2	28571764
Pubmed	Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.	PRKCB PRKCD	1.82e-05	2	149	2	24721208
Pubmed	Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.	POU4F1 POU4F2	1.82e-05	2	149	2	10414983
Pubmed	Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.	POU4F1 POU4F2	1.82e-05	2	149	2	7904822
Pubmed	Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.	RAF1 PAK1	1.82e-05	2	149	2	12551923
Pubmed	NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons.	POU4F1 POU4F2	1.82e-05	2	149	2	9582431
Pubmed	An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.	NUDT11 NUDT10	1.82e-05	2	149	2	12105228
Pubmed	Brn3a and Brn3b knockout mice display unvaried retinal fine structure despite major morphological and numerical alterations of ganglion cells.	POU4F1 POU4F2	1.82e-05	2	149	2	27391320
Pubmed	Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.	PTPRC PRKCD	1.82e-05	2	149	2	24515435
Pubmed	A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.	ZAP70 PTPRC	1.82e-05	2	149	2	19841086
Pubmed	Protein kinase C-δ and -β coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes.	PRKCB PRKCD	1.82e-05	2	149	2	25548371
Pubmed	Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.	PRKCB PRKCD	1.82e-05	2	149	2	12117979
Pubmed	Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages.	PRKCB PRKCD	1.82e-05	2	149	2	16930534
Pubmed	Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: higher expression of ZAP70 and PKC-beta II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN.	ZAP70 PRKCB	1.82e-05	2	149	2	17926183
Pubmed	NMDA receptor activation increases free radical production through nitric oxide and NOX2.	CYBB NOS1	1.82e-05	2	149	2	19244529
Pubmed	ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange.	PTK2 OSBPL2	1.82e-05	2	149	2	34124795
Pubmed	Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.	RAF1 PAK1	1.82e-05	2	149	2	11733498
Pubmed	Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia.	HHEX NUP98	1.82e-05	2	149	2	18388181
Pubmed	Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability.	PRKCB PRKCD	1.82e-05	2	149	2	18497307
Pubmed	A single amino acid change converts an inhibitory transcription factor into an activator.	POU4F1 POU4F2	1.82e-05	2	149	2	8662774
Pubmed	Differential expression and subcellular localization of Copines in mouse retina.	POU4F1 POU4F2	1.82e-05	2	149	2	30866042
Pubmed	Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood-brain barrier.	CYBB PRKCB	1.82e-05	2	149	2	34398388
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	1.82e-05	2	149	2	11744674
Pubmed	Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.	MYH13 EFCAB6 NUP98 MSANTD2 KRI1 IFNLR1 RIMS1 CFAP61	2.02e-05	265	149	8	19240061
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH1 PRKCB PRKCD	2.14e-05	13	149	3	8948582
Pubmed	Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.	RAF1 ZAP70 PAK1	2.14e-05	13	149	3	15688026
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	AKAP8 GPATCH1 NUP98 DDX27 DNTTIP2 RPL10A PBRM1 DDX18 RBM6 DHX29	2.17e-05	440	149	10	34244565
Pubmed	DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.	POU4F1 POU4F2 PAK1	2.71e-05	14	149	3	19945391
Pubmed	Identification of potential protein interactors of Lrrk2.	AKAP8 LRRK2 MDN1	3.38e-05	15	149	3	17400507
Pubmed	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	CYBB SPP1 ZAP70 PTK2 PAK1 NOS1	3.40e-05	141	149	6	20056178
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	CYBB AMPD1 SPP1 LRRK2 POU4F1 PLA2G4E BCLAF3 PHKA1 NUDT11 LOXL2 NUDT10 PLXNA4	3.62e-05	674	149	12	37196079
Pubmed	The functional interactome landscape of the human histone deacetylase family.	ZNF326 AKAP8 NUP98 CCT4 RREB1 DDX27 DNTTIP2 MDN1	3.73e-05	289	149	8	23752268
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	ZNF326 NUP98 KRI1 CCT4 PPA1 RREB1 DDX27 DNTTIP2 RPL10A PBRM1 NUDT4 MDN1 DDX18 EIF2B4 AFG3L2 PRKCB RPL7	5.32e-05	1318	149	17	30463901
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH4	5.45e-05	3	149	2	26059207
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	5.45e-05	3	149	2	36515178
Pubmed	PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival.	RAF1 PAK1	5.45e-05	3	149	2	18668521
Pubmed	Attenuation of mouse mesangial cell contractility by high glucose and mannitol: involvement of protein kinase C and focal adhesion kinase.	PTK2 PRKCD	5.45e-05	3	149	2	14966364
Pubmed	Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems.	POU4F1 POU4F2	5.45e-05	3	149	2	9598366
Pubmed	No association between POU4F1, POU4F2, ISL1 polymorphisms and normal-tension glaucoma.	POU4F1 POU4F2	5.45e-05	3	149	2	32597291
Pubmed	Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase.	PTK2 PRKCB	5.45e-05	3	149	2	28755662
Pubmed	Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse.	POU4F1 POU4F2	5.45e-05	3	149	2	21935940
Pubmed	Prolactin-induced PAK1 tyrosyl phosphorylation promotes FAK dephosphorylation, breast cancer cell motility, invasion and metastasis.	PTK2 PAK1	5.45e-05	3	149	2	27542844
Pubmed	Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-delta in TNF-alpha-activated neutrophils.	PRKCB PRKCD	5.45e-05	3	149	2	11078718
Pubmed	Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.	PRKCB PRKCD	5.45e-05	3	149	2	18067888
Pubmed	Protein kinase C βII and δ/θ play critical roles in bone morphogenic protein-4-stimulated osteoblastic differentiation of MC3T3-E1 cells.	PRKCB PRKCD	5.45e-05	3	149	2	20971075
Pubmed	Doppel expression is regulated by the Brn-3a and Brn-3b transcription factors.	POU4F1 POU4F2	5.45e-05	3	149	2	15094508
Pubmed	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.	ZAP70 PTPRC	5.45e-05	3	149	2	29980684
Pubmed	Systematic identification of intergenic long-noncoding RNAs in mouse retinas using full-length isoform sequencing.	POU4F1 POU4F2	5.45e-05	3	149	2	31286854
Pubmed	Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.	POU4F1 POU4F2	5.45e-05	3	149	2	24736625
Pubmed	Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase.	ZAP70 PTPRC	5.45e-05	3	149	2	7737297
Pubmed	Pou4f2-GFP knock-in mouse line: A model for studying retinal ganglion cell development.	POU4F1 POU4F2	5.45e-05	3	149	2	27532212
Pubmed	Interleukin-6, osteopontin and Raf/MEK/ERK signaling modulate the sensitivity of human myeloma cells to alkylphosphocholines.	RAF1 SPP1	5.45e-05	3	149	2	22421411
Pubmed	Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.	PRKCB PRKCD	5.45e-05	3	149	2	17404251
Pubmed	POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.	POU4F1 POU4F2	5.45e-05	3	149	2	9448000
Pubmed	Assignment of human genes for phosphorylase kinase subunits alpha (PHKA) to Xq12-q13 and beta (PHKB) to 16q12-q13.	PHKA1 PRKCB	5.45e-05	3	149	2	2757032
Cytoband	2p15	USP34 CCT4 FAM161A	1.41e-04	31	149	3	2p15
Cytoband	Ensembl 112 genes in cytogenetic band chr2p15	USP34 CCT4 FAM161A	4.02e-04	44	149	3	chr2p15
GeneFamily	Myosin heavy chains	MYH1 MYH4 MYH13	6.50e-05	15	97	3	1098
GeneFamily	Nudix hydrolase family	NUDT11 NUDT4 NUDT10	2.79e-04	24	97	3	667
GeneFamily	C2 domain containing protein kinases	PRKCB PRKCD	1.25e-03	10	97	2	835
ToppCell	B_cells-Memory_B_cells\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	CYBB HHEX CNTRL LRRK2 RPL10A PTPRC CD48 PRKCB	3.44e-07	197	149	8	cdd1dbdaf257b0864c6dc8c1cbed6e9b68e114b7
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PKD1L1 POU4F1 BARX2 MROH2B SPOCD1 MAP4K4	4.20e-07	85	149	6	159b3ac93490c3e4918ea61f8ede7add9e63ca40
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERO1B CARMIL3 POU4F1 CHGB MYLK4 GLUL PRKCB	1.48e-06	166	149	7	66026988509e39e41274fa0de738383219e8ff30
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH13 PKHD1L1 ABCC12	2.07e-06	62	149	5	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYH1 MYH4 MYH13 PKHD1L1 ABCC12	2.07e-06	62	149	5	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	EFCAB6 ESRRG GRM7 SNTN CFAP299 CFAP61 PACRG	2.73e-06	182	149	7	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	EFCAB6 ESRRG GRM7 SNTN CFAP299 CFAP61 PACRG	3.04e-06	185	149	7	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	P15-Epithelial-airway_epithelial_cell-club_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EFCAB6 BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.27e-06	187	149	7	a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	EFCAB6 ESRRG FHOD3 SNTN CFAP299 CFAP61 PACRG	3.38e-06	188	149	7	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	P15-Epithelial-airway_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EFCAB6 BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.38e-06	188	149	7	e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ESRRG SNTN CFAP299 EFHC1 CFAP61 PACRG	3.50e-06	189	149	7	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BARX2 SNTN KCNH3 CFAP299 FAM161A CFAP61 PACRG	3.75e-06	191	149	7	649fcb62ad15de2f83e61591e43923a717664ae7
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BARX2 SNTN KCNH3 CFAP299 FAM161A CFAP61 PACRG	3.75e-06	191	149	7	9621e22e14ea069f22713947c9faa2d882abe5fe
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BARX2 SNTN KCNH3 CFAP299 FAM161A CFAP61 PACRG	3.75e-06	191	149	7	6a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ESRRG SNTN CFAP299 EFHC1 CFAP61 PACRG	4.02e-06	193	149	7	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	EFCAB6 ESRRG SNTN CFAP299 EFHC1 CFAP61 PACRG	4.02e-06	193	149	7	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal-BMP_responsible_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX SPP1 PIEZO1 BARX2 RREB1 PTPRC PRKCD	5.08e-06	200	149	7	26251ed8c7fa7e87973d6f59bd398c88ad025395
ToppCell	PND01-03-samps-Myeloid-Granulocyte\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYBB ARHGAP11A PTPRC CD48 PRKCB PRKCD	1.11e-05	149	149	6	7bdb396de8a1ef27ab0c2aaf1452576f4b0b5561
ToppCell	PND01-03-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CYBB ARHGAP11A PTPRC CD48 PRKCB PRKCD	1.11e-05	149	149	6	50f53018e525b3d252caa8bed9e075b1bb1086dd
ToppCell	Control-PLT_4\|World / Disease Group and Platelet Clusters	HHEX ZNF326 ERO1B ARMCX1 EIF4ENIF1 CLDN16	1.34e-05	154	149	6	a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell	droplet-Limb_Muscle-nan-18m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB GDAP1 RNF183 ARHGAP11A IFNLR1 CD48	1.78e-05	162	149	6	71d7849108a1b59beff40e46000172c45a2f5439
ToppCell	PND07-28-samps-Myeloid\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CYBB SPP1 PTPRC CD48 PRKCD PNPLA7	2.19e-05	168	149	6	87512f9e5e95333e7ffc6efa1e93bab2ba9154c6
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|Endothelial_cells / Location, Cell class and cell subclass	EFCAB6 ZAP70 KCNH3 PTPRC CD48 PRKCB	2.42e-05	171	149	6	dcb6c41980008d0b9eeb54999faff77311554976
ToppCell	facs-Lung-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYBB PTPRC PAK1 CD48 PRKCB PRKCD	2.42e-05	171	149	6	4ad28ecfde3d529a09b80be908c446bd5274518e
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LOXL2 PLXNA4 PAK1 MED12L PRKCB NOS1	2.42e-05	171	149	6	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	droplet-Limb_Muscle-nan-21m-Lymphocytic-B_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB ERO1B CFAP299 PTPRC CD48 PRKCB	2.50e-05	172	149	6	62734d231290ca725276dc62faa2ac87bd1b37b8
ToppCell	facs-Lung-EPCAM-18m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB PTPRC PAK1 CD48 PRKCB PRKCD	2.58e-05	173	149	6	50b25b7f8f29b60c22782a4492fe4b089fe7d69d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYH1 MYH4 LRRK2 KCTD16 CFAP61 UNC5D	2.75e-05	175	149	6	284fdc7a9d303636a637041846850d19d114861a
ToppCell	PND28-Immune\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB RPL10A PTPRC CD48 PRKCD RPL7	2.94e-05	177	149	6	087bcda36589e3554e6f2c170542a4be7833cfd2
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	SPP1 NUDT11 XPO6 C2orf42 ZFP69B SPOCD1	3.03e-05	178	149	6	536a601abcc60867949ea06e9aafb6c7b799b56b
ToppCell	droplet-Liver-LIVER_HEP-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH1 AMPD1 CHGB PKHD1L1 MMP24 NUDT10	3.13e-05	179	149	6	4135f9e8cd8494cbc189e5210dded84659643fb8
ToppCell	P03-Epithelial-airway_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.33e-05	181	149	6	1ea21d860d4d7abab3e21e130a16d044006656ee
ToppCell	P03-Epithelial-airway_epithelial_cell-club_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.33e-05	181	149	6	60a91587c59029a34e7bec1255083337fe21b72a
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDYN FHOD3 MMP24 MED12L PNPLA7 NOS1	3.43e-05	182	149	6	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	CF-Myeloid-Neutrophil\|CF / Disease state, Lineage and Cell class	ATG2A XPO6 GLUL PAK1 PRKCB MAP4K4	3.54e-05	183	149	6	da43827952e6fdee2ce94648c316182f272b321c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ESRRG LRRK2 GRM7 KCNH3 RIMS1 NOS1	3.65e-05	184	149	6	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	P07-Epithelial-airway_epithelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.65e-05	184	149	6	a5e7af3392e9d6ddad0397f1eeb6b91ed1107cc2
ToppCell	P07-Epithelial-airway_epithelial_cell-club_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	BARX2 SNTN CFAP299 FAM161A CFAP61 PACRG	3.65e-05	184	149	6	ab469b9e06212462cbe2e4db8775c6778db855e6
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ESRRG SNTN CFAP299 CLDN16 CFAP61 PACRG	3.65e-05	184	149	6	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	droplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZHX3 ALS2 ZDHHC17 PHKA1 TMEM132A MTTP	3.76e-05	185	149	6	6a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCell	droplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZHX3 ALS2 ZDHHC17 PHKA1 TMEM132A MTTP	3.76e-05	185	149	6	64791056cdbb739136dbef08f4b16e2b5427faad
ToppCell	(1)_B_CD27neg\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	CYBB HHEX PKHD1L1 PTPRC CD48 PRKCB	3.87e-05	186	149	6	646389147189760e9493c4f50f9583959ef0ee26
ToppCell	COVID-19-kidney-Mito-rich_Distal\|kidney / Disease (COVID-19 only), tissue and cell type	SPP1 ESRRG LRRK2 NUDT4 CLDN16 NOS1	3.99e-05	187	149	6	2ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCell	3'_v3-blood\|World / Manually curated celltypes from each tissue	ZNF326 TSHZ2 ATG2A RPL10A CD48 RPL7	3.99e-05	187	149	6	9e70e8d7cd8ae517ddf5fd56c69ec16fc33ddff5
ToppCell	Epithelial-ciliated_cell\|World / Lineage, Cell type, age group and donor	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.11e-05	188	149	6	61a459f3fe57e5728efc72637ff2edc2d343492b
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ESRRG SNTN CFAP299 CLDN16 CFAP61 PACRG	4.11e-05	188	149	6	2b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SNTN KCNH3 CFAP299 EFHC1 NUDT11 PACRG	4.23e-05	189	149	6	fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.23e-05	189	149	6	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	Monocytes-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	CYBB HHEX PTPRC CD48 PRKCB DSE	4.23e-05	189	149	6	22d08c7dde697f385100f72e009eeac8d19d329d
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.23e-05	189	149	6	68a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.23e-05	189	149	6	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPP1 ESRRG RPL10A NUDT4 CLDN16 NOS1	4.23e-05	189	149	6	55420853f730b433ef58ac9337ac84ac78a247a0
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.49e-05	191	149	6	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.49e-05	191	149	6	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EFCAB6 ESRRG SNTN CFAP299 CFAP61 PACRG	4.49e-05	191	149	6	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	ESRRG SNTN CFAP299 EFHC1 CFAP61 PACRG	4.62e-05	192	149	6	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	droplet-Lung-21m-Hematologic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYBB RPL10A PTPRC CD48 PRKCB RPL7	4.62e-05	192	149	6	3404d5feaad15bb1b040e8c146b6e88f1cc43eb9
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CYBB LRRK2 PTPRC CD48 PRKCB DSE	4.90e-05	194	149	6	b191851b2287afc8c47320f5488fd22e2a454aa6
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB HHEX LRRK2 RPL10A CD48 PRKCB	5.04e-05	195	149	6	f43dacc972dc4df574c4639952d3be9fc4201d33
ToppCell	PBMC\|World / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.04e-05	195	149	6	211eba45a502b961873ca2d4642f7852e6e89d7a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-cDC2-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PPA1 PTPRC PAK1 CD48 PRKCD DSE	5.04e-05	195	149	6	a2fe352682f548001ca2ee056e7a54af10134453
ToppCell	metastatic_Lymph_Node-T/NK_cells-Naive_CD4+_T\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TSHZ2 ZAP70 RPL10A PTPRC CD48 RPL7	5.04e-05	195	149	6	c72943618ced6797202894f78fbb8f300c2e4387
ToppCell	PBMC\|World / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.04e-05	195	149	6	8cd7667a65d77dd7b301090a9b65aba254741375
ToppCell	3'\|World / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TSHZ2 PSMB7 NDUFB8 RTF1 RPL10A RPL7	5.18e-05	196	149	6	44007f0c14e0f0703f7ee715b8eababb4d80a8b5
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	ESRRG SNTN PTK2 CFAP299 TANC1 PACRG	5.18e-05	196	149	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	ESRRG SNTN PTK2 CFAP299 TANC1 PACRG	5.18e-05	196	149	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	normal_Lung-Endothelial_cells-EPCs\|Endothelial_cells / Location, Cell class and cell subclass	CYBB ZAP70 PTPRC CD48 PRKCB SPOCD1	5.33e-05	197	149	6	bfdde765bf05c5bff88bc3ab5175bfe61e79ed60
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CYBB HHEX RPL10A PRKCB MBD4 MAP4K4	5.33e-05	197	149	6	85b5d284e7799335a1829a5d2d56bb0845f5cec5
ToppCell	distal-Hematologic-Classical_Monocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CYBB LRRK2 PTPRC CD48 PRKCB RPL7	5.33e-05	197	149	6	9f4b0857012cd503e668bac115010216a946f73c
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB HHEX RPL10A CD48 PRKCB RPL7	5.33e-05	197	149	6	b700b4c73da439d7102b8925ef16980f022c91fd
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	TSHZ2 PDYN PGM2L1 CHGB KCTD16 UNC5D	5.33e-05	197	149	6	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Memory_B\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB LRRK2 RPL10A CD48 PRKCB RPL7	5.48e-05	198	149	6	af4476194fe932689f57ef875a3085abc57e3496
ToppCell	10x3'2.3-week_12-13-Myeloid_monocytic-monocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CYBB LRRK2 PAK1 CD48 PRKCD RPL7	5.48e-05	198	149	6	64bb74e2aadfc68937464ddf0a435d7230004dcb
ToppCell	Macrophages-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	CYBB SPP1 PTPRC CD48 PRKCB DSE	5.48e-05	198	149	6	8517386a2f0d14c7d5fc6283e4e16b94d7c5732a
ToppCell	10x3'2.3-week_12-13-Myeloid_monocytic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CYBB LRRK2 PAK1 CD48 PRKCD RPL7	5.48e-05	198	149	6	de8417b536448312d6c82e424b45a610f8a455d6
ToppCell	distal-Hematologic-CD8+_Memory/Effector_T-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.64e-05	199	149	6	a2f54e56013ec2c83407fdb3fcbe5d10d146cca4
ToppCell	NS-critical\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYBB PTPRC CD48 PRKCB MAP4K4 DSE	5.64e-05	199	149	6	f7c14dc9a9e659f89352dccf8954d6cbada011ab
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_DC2\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PSMB7 PPA1 RPL10A PAK1 CD48 RPL7	5.64e-05	199	149	6	829ec877c6c16c4abf8d3d139aea94af599406fe
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPP1 RPL10A NUDT4 CLDN16 NOS1 RPL7	5.64e-05	199	149	6	9c89148d42bc442a1f08bc00225c01aa1f1d91f3
ToppCell	distal-Hematologic-CD8+_Naive_T\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.80e-05	200	149	6	127389d7a96aaec29b280e77d0a7a30856e47360
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Mesenchymal\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX PIEZO1 BARX2 CFAP299 PTPRC PRKCD	5.80e-05	200	149	6	fe22f7c97f4e37dfa7881d0f1d9245c1237d873b
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CYBB HHEX RPL10A PTPRC CD48 PRKCB	5.80e-05	200	149	6	d124acbe5d46220850fe485ed78f032daddca5b1
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX PIEZO1 RREB1 ZAP70 PRKCD TANC1	5.80e-05	200	149	6	25f4c051c2e869481f33c22ad54de97efac444ad
ToppCell	distal-1-Hematologic-CD8+_Memory/Effector_T\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.80e-05	200	149	6	daed8b9c19557fba9e7bf1e41e27688ab49ca366
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Lymphocytic-B_cells-B-cells\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	CYBB HHEX RPL10A PTPRC CD48 PRKCB	5.80e-05	200	149	6	c07e37db9d50b91378d9c8355168745560cdbd25
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	HHEX PIEZO1 RREB1 ZAP70 PRKCD TANC1	5.80e-05	200	149	6	da45a85a4667965b24ba824af871157af5b4cd19
ToppCell	distal-Hematologic-CD8+_Naive_T-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ZAP70 RPL10A PTPRC CD48 PRKCB RPL7	5.80e-05	200	149	6	12f65cc8f1b63dddd75183f636261550cd7adadd
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYH1 MYH4 LRRK2 KCTD16 UNC5D	9.46e-05	136	149	5	82b1d6d839c0d0c68e0960549f688138479defcc
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CYBB ERO1B LRRK2 CHGB DSE	9.79e-05	137	149	5	12caa8ed7cc9e7a0f78c14ad5efe2fc28c3ce9be
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYH1 MYH4 LRRK2 KCTD16 UNC5D	9.79e-05	137	149	5	0aa4e14b32da0cda677cc0ed6ae470f6ecd77bea
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB ESRRG F9 PTPRC PAK1	1.24e-04	144	149	5	f5d0d0564fcbec8a5d87119e0807b619faa77b0f
ToppCell	P07-Hematopoietic-Immune\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYBB SPP1 PTPRC CD48 PRKCB	1.24e-04	144	149	5	962698c5c15bd583fccda0593b7aab5f2eb4bc9f
ToppCell	COVID-19-Heart-CM_5_(RYR2-)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYH1 AMPD1 PHKA1 FAM181A NOS1	1.24e-04	144	149	5	f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCell	P07-Hematopoietic-Immune-immune_cell_unspecified\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYBB SPP1 PTPRC CD48 PRKCB	1.24e-04	144	149	5	eb057dbdb2a5a2d29b93e5ed5479a3fd1bf3fd26
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB PTPRC PAK1 CD48 PRKCD	1.41e-04	148	149	5	31a7c2b20970070b14d2b955020320a6f99db547
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB ESRRG F9 PTPRC PAK1	1.45e-04	149	149	5	32e0be7da42d26956683b21a1e7ae6915e4c16fb
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|390C / Donor, Lineage, Cell class and subclass (all cells)	CARMIL3 ZAP70 PTPRC CD48 PRKCB	1.50e-04	150	149	5	fdbfc8f743cf848978cf0488493f6df60be53982
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB PTPRC PAK1 CD48 PRKCD	1.59e-04	152	149	5	27718e92715ddc80f28b457a5d6d6a3ac2b205d2
ToppCell	PND01-03-samps-Epithelial-Epithelial-non_alveolar\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	EFCAB6 SNTN ZAP70 CFAP299 EFHC1	1.64e-04	153	149	5	fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|367C / Donor, Lineage, Cell class and subclass (all cells)	PGM2L1 CHGB ZAP70 PTPRC ZFP69B	1.64e-04	153	149	5	da1bff9928d8c61bb1c389d45fd897cfa4bed023
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0111269 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0111602 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0111596 (implicated_via_orthology)
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0110454 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0080719 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13	1.33e-05	10	144	3	DOID:0080326 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13	2.42e-05	12	144	3	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH4 MYH13	2.42e-05	12	144	3	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH4 MYH13	3.14e-05	13	144	3	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH4 MYH13	4.96e-05	15	144	3	DOID:0050646 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	RAF1 MYH1 HHEX AKAP8 SPP1 NUP98 PPA1 ARHGAP11A PBRM1 PTPRC LOXL2 DDX18 PAK1 ZFYVE26 KAT6B SPOCD1	7.45e-05	1074	144	16	C0006142
Disease	opioid overdose severity measurement	CFAP299 DDX18	1.41e-04	4	144	2	EFO_0010140
Disease	migraine disorder, type 2 diabetes mellitus	ZHX3 RREB1 KCTD16 SENP6	2.15e-04	60	144	4	MONDO_0005148, MONDO_0005277
Disease	Parkinson's disease (is_marker_for)	LRRK2 NDUFB8 AFDN NOS1	3.28e-04	67	144	4	DOID:14330 (is_marker_for)
Disease	Autosomal Dominant Parkinsonism	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0752097
Disease	Parkinsonism, Experimental	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0752101
Disease	Autosomal Recessive Parkinsonism	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0752100
Disease	Familial Juvenile Parkinsonism	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C0242423
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	PDYN LRRK2 PRKCD	3.41e-04	28	144	3	C1868675
Disease	leiomyoma (is_implicated_in)	PTK2 KAT6B	3.50e-04	6	144	2	DOID:127 (is_implicated_in)
Disease	cardiomyopathy (implicated_via_orthology)	RAF1 MYH1 MYH4 MYH13	4.10e-04	71	144	4	DOID:0050700 (implicated_via_orthology)
Disease	Parkinsonism, Juvenile	PDYN LRRK2 PRKCD	4.20e-04	30	144	3	C0752105
Disease	Parkinsonian Disorders	PDYN LRRK2 PRKCD	4.20e-04	30	144	3	C0242422
Disease	hypertension (implicated_via_orthology)	PTK2 CLDN16 PRKCB PRKCD NOS1	4.22e-04	128	144	5	DOID:10763 (implicated_via_orthology)
Disease	cerebellar ataxia (implicated_via_orthology)	VPS13A PNPLA7	6.50e-04	8	144	2	DOID:0050753 (implicated_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	TBPL2 FAT4 LRRK2 AFG3L2 PNPLA7	7.44e-04	145	144	5	DOID:1289 (implicated_via_orthology)
Disease	Proteinuria	CYBB SPP1 PAK1	1.22e-03	43	144	3	C0033687
Disease	myopathy (implicated_via_orthology)	MYH1 MYH4 MYH13	1.68e-03	48	144	3	DOID:423 (implicated_via_orthology)
Disease	Fulminant Hepatic Failure with Cerebral Edema	GLUL NOS1	1.78e-03	13	144	2	C0751197
Disease	Hepatic Stupor	GLUL NOS1	1.78e-03	13	144	2	C0751198
Disease	Hepatic Encephalopathy	GLUL NOS1	1.78e-03	13	144	2	C0019151
Disease	Hepatic Coma	GLUL NOS1	1.78e-03	13	144	2	C0019147
Disease	Childhood Ataxia with Central Nervous System Hypomyelinization	SPP1 EIF2B4	2.07e-03	14	144	2	C1858991
Disease	myocarditis (implicated_via_orthology)	SPP1 PPA1	2.07e-03	14	144	2	DOID:820 (implicated_via_orthology)
Disease	severe combined immunodeficiency (is_implicated_in)	ZAP70 PTPRC	2.07e-03	14	144	2	DOID:627 (is_implicated_in)
Disease	Hepatitis C	PTPRC LOXL2	2.38e-03	15	144	2	C0019196
Disease	vitamin K-dependent protein C measurement	CNBD2 MMP24	2.38e-03	15	144	2	EFO_0008318
Disease	femoral neck bone mineral density	TBPL2 SPP1 GPATCH1 OSBPL2 PLXNA4	2.81e-03	196	144	5	EFO_0007785
Disease	response to cyclophosphamide	BARX2 TMX1	3.07e-03	17	144	2	GO_1902518
Disease	diet measurement, HOMA-B	RAB11FIP2 PLXNA4	3.83e-03	19	144	2	EFO_0004469, EFO_0008111
Disease	Omenn Syndrome	ZAP70 PTPRC	3.83e-03	19	144	2	C2700553
Disease	Severe Combined Immunodeficiency	ZAP70 PTPRC	4.24e-03	20	144	2	C0085110
Disease	Seizures	PDYN GLUL MED12L PRKCD NOS1	4.41e-03	218	144	5	C0036572
Disease	response to ketamine	KIAA1671 XPO6 MROH2B	4.71e-03	69	144	3	EFO_0009748

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRYGARKQPSVEAVK	C2orf42	51	Q9NWW7
KPRPKSEGFELYNNS	AFDN	1121	P55196
NPTEKPRQYLKRVFE	CFAP61	1191	Q8NHU2
APDESPYIGKSRYKR	CNTRL	381	Q7Z7A1
AYQRFCSRPPKGFEK	AFG3L2	61	Q9Y4W6
YLNSRDELFDRKPPA	BEGAIN	326	Q9BUH8
TGRKRKQFQLYEEPD	AKAP8	301	O43823
PSLYESDKDRPKVFR	ALS2	1266	Q96Q42
GTKDPSRNRYKLFLE	ATP13A1	466	Q9HD20
ETKGEGPRRLKNLYF	ERO1B	291	Q86YB8
YKLNITAKDQGRPPR	FAT4	1386	Q6V0I7
KDVGPERNYPYSLRK	CLDN16	191	Q9Y5I7
QRFPKTPSKYLRNID	AMPD1	156	P23109
REPRVKQGPKIYSFN	DHX29	56	Q7Z478
KQYRAGPSFEERKQL	DDX27	761	Q96GQ7
ALDPKSTGRKYFLPQ	ATG2A	721	Q2TAZ0
KPYRRLSEREFDPNK	ATXN7L1	281	Q9ULK2
LGKRLREYFNSEKPE	MSANTD2	341	Q6P1R3
NQTRTYDPEGFKKRA	NUDT10	6	Q8NFP7
EKNKIRPRGQRDSSY	RAF1	326	P04049
PGAVERVKKLRDYAF	RBM46	261	Q8TBY0
SKKFRRPDIQYPDAT	SPP1	171	P10451
PTKPTAFRKFYERGD	PACRG	66	Q96M98
KQKVARYFPTERGQP	PTPN23	1296	Q9H3S7
EADFAKRGYKLPKVR	PSMB7	26	Q99436
PPANEIYRRKDLSVF	KAT6B	776	Q8WYB5
NLPEYKVAAIRKSPF	KCNH3	201	Q9ULD8
KEPARRANGYKTFRL	ATOH8	31	Q96SQ7
RGPPNKRFYEKAEES	OGFOD1	321	Q8N543
KFDNQKLSVEPGYPR	MMP24	546	Q9Y5R2
EKRSLEAYFAVQPRP	POU4F1	366	Q01851
PQSDTPEIRKYKKRF	MAP4K4	911	O95819
SRKQGAQFKEYRPET	NUP98	856	P52948
GEERNPTSKYYRNKR	PBRM1	321	Q86U86
LPQARFDPAVKREYK	MDN1	3236	Q9NU22
KREKPRELIFPSNYD	MED12L	686	Q86YW9
KRAYSEKGPPANIRE	KIAA1671	1406	Q9BY89
DLYNKFKGRVRTVSP	IFNLR1	91	Q8IU57
PEKGRLKREAEYFQL	KCTD16	101	Q68DU8
PNQTRTYDREGFKKR	NUDT4B	6	A0A024RBG1
RPKVKSPRDYSNFDQ	PRKCD	621	Q05655
PGASRDEVNKAYRKL	DNAJC27	226	Q9NZQ0
FETQKYLSPPERKRL	HHEX	156	Q03014
FLRDGYKTPKEDPNR	PHKA1	296	P46020
VFSPDGPSRFRKAYK	LOXL2	306	Q9Y4K0
RKGREAPPAFKQFFS	CARMIL3	406	Q8ND23
GLPRVKRDKYSVFNF	GPATCH1	636	Q9BRR8
PGYRQERVEKGLKLF	PLXNA4	1341	Q9HCM2
VEFNDRNKPRYPKAS	LCTL	476	Q6UWM7
PNQTRTYDREGFKKR	NUDT4	6	Q9NZJ9
PFRQFEKKYERLSTG	MTTP	836	P55157
RLRNFDSPKEYPKFC	PGM2L1	506	Q6PCE3
EDPKEQVKRYGGFLR	PDYN	166	P01213
LNRPKRYNSGKLEEF	F9	41	P00740
GKRPNLETYYERVLK	GDAP1	271	Q8TB36
ARRYKPREKLKVNFG	MYLK4	251	Q86YV6
KELLNKRGFPAIRDY	LRRK2	1471	Q5S007
RAGKRYKFVDAVPDI	DSE	811	Q9UL01
ADYDPSQPRKKKREA	KRI1	456	Q8N9T8
PYKPKARDKRDTSNF	PRKCB	616	P05771
KGFPSRILYADFKQR	MYH1	711	P12882
NQTRTYDPEGFKKRA	NUDT11	6	Q96G61
YPRTPEERAAAAKKY	NDUFB8	41	O95169
RPEELGFLRYLKQSK	DDX18	531	Q9NVP1
RKAGNFYVPAEPKLA	RPL7	76	P18124
KPERQQVPTRKDYGS	EIF2B4	161	Q9UI10
QAQPTPQYRFRKRDK	PNPLA7	41	Q6ZV29
KPRKSYSLGRDQVAP	OR8H3	261	Q8N146
RELYTAYSREPDKPK	NOS1	1311	P29475
KGRSQDYPDTPEKRD	RIMS1	321	Q86UR5
KDKSRLRYPINGFQA	TM7SF2	91	O76062
KDRFYRSILPGDKTN	PAK1	51	Q13153
NDTFRKYKAPGVERS	PLA2G4E	786	Q3MJ16
KQLKDRYPRKRFVAG	GTPBP10	56	A4D1E9
EEDRKYSFQKGPLNR	BCLAF3	306	A2AJT9
RTPDQGKKYLRDADR	CABIN1	1631	Q9Y6J0
VNAKGRLKYPDFLSR	EFCAB6	1226	Q5THR3
ALAFYRAKNPTDKPV	COX11	181	Q9Y6N1
GRQKYKRRIDAENSP	ESRRG	206	P62508
SPGQLKAARRRYKTF	BARX2	11	Q9UMQ3
KRREYRNSLNPFKGL	C14orf93	371	Q9H972
PSFKPNQVRDLREKY	FHOD3	386	Q2V2M9
QTSPKKQEEARREYP	BTBD7	996	Q9P203
KYNKEALSPPRRKAF	MBD4	421	O95243
RRYKVPDGKPENEFA	PPA1	191	Q15181
SYLNFARKRIKNPEG	CYBB	151	P04839
RKQPLRKYVTPSDFD	EFHC1	216	Q5JVL4
YRIFEQGKKSVTAPR	GRM7	681	Q14831
KTNRFKARPIPRSTY	FAM161A	351	Q3B820
PRPSKEVESFARKNY	GPX8	116	Q8TED1
YFESKFKGRVRLDPQ	CD48	76	P09326
YGDKRPFPKELQNSV	CD48	166	P09326
TAEKRKRLGELFNPY	CHGB	511	P05060
DYDRKPPNRYLAKAV	PKD1L1	1666	Q8TDX9
GRIRSKFSNNAKYDP	ENPP2	391	Q13822
QLKRFSQKYSRLPRG	FAM181A	106	Q8N9Y4
PRTVGQEKKGYFEDR	GLUL	326	P15104
QEKKGYFEDRRPSAN	GLUL	331	P15104
VKEKERFRKAPPNYA	RTF1	496	Q92541
YLKRRQYVDSDGPLK	TAF5L	16	O75529
QSFDSPERKRIKYSR	RBM6	1021	P78332
EYETPGEYKRKRRQS	ARHGAP11A	271	Q6P4F7
KDQPKSRYFLRQPQV	RNF183	101	Q96D59
FVLRYQRKEPPDSAT	TMEM132A	871	Q24JP5
EKRSLEAYFAIQPRP	POU4F2	356	Q12837
YDPSRRPRFTELKAQ	PTK2	661	Q05397
RNFAEGQETKPKYRE	SNTN	91	A6NMZ2
IFYRNEIRKVTGKDP	PLEKHJ1	116	Q9NW61
RAQEVKARFAPYKPQ	TANC1	351	Q9C0D5
KGAYQDRDKPAQIRF	CCT4	21	P50991
KGFPSRILYADFKQR	MYH4	711	Q9Y623
DFPYPRLDANRLSDK	MROH2B	171	Q7Z745
KQRSEAYSERSPPAK	ABCC12	466	Q96J65
PVSYESFKKQERRGD	OSBPL2	311	Q9H1P3
RYTKEQDYRPKATGR	EIF4ENIF1	776	Q9NRA8
DNPEGLLFRYKRDRK	CFAP299	181	Q6V702
PVRRGKFNFPYKIDD	ARMCX1	186	Q9P291
SQLFTPNRPKKREIY	CNBD2	511	Q96M20
DPKRFYKKNDRDGFP	DNTTIP2	671	Q5QJE6
KFLLRPRKEQGTYAL	ZAP70	186	P43403
RSEDPPKRIYFNKQE	VPS13A	2361	Q96RL7
PPEDKLLRAKRNSYT	RREB1	1226	Q92766
SKVEKRYYQPDDRRP	SPOCD1	1041	Q6ZMY3
KGFPSRILYADFKQR	MYH13	711	Q9UKX3
AQSSLDRKERKEYPP	SENP6	151	Q9GZR1
LRVPYEPSRKAGKFS	RAB11FIP2	496	Q7L804
VLFDSADVKPNRRPY	PKHD1L1	721	Q86WI1
TGPKAFKIPYSIRQR	UNC5D	846	Q6UXZ4
FKDYRKLSQERPGVL	TTLL12	341	Q14166
RPTSYSKPRKRAFQD	TSHZ2	251	Q9NRE2
YDPQKDKRFSGTVRL	RPL10A	41	P62906
PLYERARKPEGSKNL	nan	141	Q3C1V9
RQAKGYDNPSFLRKL	ZDHHC17	281	Q8IUH5
KPYRGSVEEALFVKR	ZNF587B	146	E7ETH6
RKYDTPGKRSRYNID	ZFP69B	251	Q9UJL9
FSGLSPYERKRLKNI	WDR76	156	Q9H967
KRIESPFAKYNRLGQ	ZNF830	36	Q96NB3
IRFGYDPRKNPDAKI	GTF3C5	301	Q9Y5Q8
KLRAYRPSGQRKEAA	PIEZO1	331	Q92508
KPPFKFSREGQEFLR	USP34	1801	Q70CQ2
DYRNLKPSAVAPQRK	XPO6	761	Q96QU8
KNISRRASYNEPKPE	TEX2	586	Q8IWB9
FTPTKYKERAPEQLR	ZHX3	611	Q9H4I2
FKEPRKYIAAQGPRD	PTPRC	716	P08575
FRRYQGPRTKKDFIN	TMX1	111	Q9H3N1
EKALDFPYPQREKRS	ZFYVE26	1726	Q68DK2
RRTIAKYAPKFDGFQ	USP6	606	P35125
FPLDKAVAYSKLRNP	PPIP5K1	116	Q6PFW1
ARKYARVVQKLGFPA	TBPL2	271	Q6SJ96
KPYRGSVEEALFAKR	ZNF814	146	B7Z6K7
KRENPYARGKPLEYD	ZNF487	206	B1APH4
PIVKARYERFVKGEN	ZNF326	456	Q5BKZ1