Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainAquaporin_12

AQP12A AQP12B

1.12e-052632IPR023265
DomainAquaporin_11/12

AQP12A AQP12B

3.35e-053632IPR016697
DomainRetinoicA-induced_16-like

FHIP1B FHIP1A

6.69e-054632IPR019384
DomainRAI16-like

FHIP1B FHIP1A

6.69e-054632PF10257
DomainLAM_G_DOMAIN

CELSR3 SLIT1 LAMA3

2.84e-0438633PS50025
DomainLaminin_G_2

CELSR3 SLIT1 LAMA3

3.31e-0440633PF02210
DomainLamG

CELSR3 SLIT1 LAMA3

4.39e-0444633SM00282
DomainLaminin_G

CELSR3 SLIT1 LAMA3

9.89e-0458633IPR001791
DomainMIP

AQP12A AQP12B

9.93e-0414632PS00221
DomainMIP

AQP12A AQP12B

9.93e-0414632PF00230
DomainMIP

AQP12A AQP12B

1.14e-0315632IPR000425
Domain-

AQP12A AQP12B

1.14e-03156321.20.1080.10
DomainAquaporin-like

AQP12A AQP12B

1.14e-0315632IPR023271
DomainCTCK_1

SLIT1 MUC2

1.65e-0318632PS01185
DomainCT

SLIT1 MUC2

2.48e-0322632SM00041
Domain-

CD163L1 TMPRSS5

3.20e-03256323.10.250.10
DomainCys_knot_C

SLIT1 MUC2

3.20e-0325632IPR006207
DomainCTCK_2

SLIT1 MUC2

3.20e-0325632PS01225
DomainWD40_repeat_dom

IFT140 ELP2 WDR90 LRRK1 HERC1

3.26e-03297635IPR017986
DomainSRCR_1

CD163L1 TMPRSS5

3.45e-0326632PS00420
DomainSRCR_2

CD163L1 TMPRSS5

3.45e-0326632PS50287
DomainSRCR-like_dom

CD163L1 TMPRSS5

3.45e-0326632IPR017448
DomainSRCR

CD163L1 TMPRSS5

3.72e-0327632IPR001190
DomainHRM

CELSR3 ADGRA2

4.00e-0328632PF02793
Domain-

CELSR3 SLIT1 LAMA3

4.06e-03956332.60.120.200
DomainEGF_LAM_2

CELSR3 LAMA3

4.58e-0330632PS50027
DomainEGF_LAM_1

CELSR3 LAMA3

4.58e-0330632PS01248
DomainLRR

SLIT1 NLRP1 LRRK1 ADGRA2

4.73e-03201634PS51450
Domain-

IFT140 ELP2 WDR90 HERC1 PLXNB2

5.28e-033336352.130.10.10
DomainWD40/YVTN_repeat-like_dom

IFT140 ELP2 WDR90 HERC1 PLXNB2

5.41e-03335635IPR015943
DomainGPS

CELSR3 ADGRA2

5.86e-0334632SM00303
DomainGPCR_2_secretin-like_CS

CELSR3 ADGRA2

5.86e-0334632IPR017983
DomainGPS

CELSR3 ADGRA2

6.20e-0335632PF01825
DomainLaminin_EGF

CELSR3 LAMA3

6.20e-0335632PF00053
DomainEGF_Lam

CELSR3 LAMA3

6.20e-0335632SM00180
DomainConA-like_dom

CELSR3 SLIT1 LAMA3 HERC1

6.38e-03219634IPR013320
DomainLRR_1

SLIT1 NLRP1 LRRK1 ADGRA2

6.38e-03219634PF00560
DomainGPS

CELSR3 ADGRA2

6.55e-0336632PS50221
DomainGPS

CELSR3 ADGRA2

6.91e-0337632IPR000203
DomainLaminin_EGF

CELSR3 LAMA3

7.28e-0338632IPR002049
DomainTPR-like_helical_dom

IFT140 TMTC2 EEF2K CDC23

7.91e-03233634IPR011990
DomainG_PROTEIN_RECEP_F2_1

CELSR3 ADGRA2

8.04e-0340632PS00649
DomainGPCR_2_extracellular_dom

CELSR3 ADGRA2

8.04e-0340632IPR001879
DomainG_PROTEIN_RECEP_F2_3

CELSR3 ADGRA2

8.04e-0340632PS50227
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

RHPN1 THADA GBF1 MDN1 CELSR3 WDR90 LRRK1 HERC1 FHIP1B PLXNB2 ADGRA2 TEX19 GAREM1

9.16e-081105641335748872
Pubmed

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.

AQP12A AQP12B

3.33e-06264219726746
Pubmed

Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.

AQP12A AQP12B

3.33e-06264236167651
Pubmed

Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.

AQP12A AQP12B

3.33e-06264215809071
Pubmed

Experimental validation of 5 in-silico predicted glioma biomarkers.

SPON1 PLXNB2

9.99e-06364224158112
Pubmed

Sialylation shapes mucus architecture inhibiting bacterial invasion in the colon.

BATF2 MUC2

2.00e-05464237385587
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

IFT140 CELSR3 USP38 SPG11 WDR90 LRRK1 ADGRA2

5.32e-0552964714621295
Pubmed

Novel Cul3 binding proteins function to remodel E3 ligase complexes.

NLRP1 WDR90 LRRK1

5.59e-054064325011449
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

CELSR3 SLIT1

1.19e-0496429693030
Pubmed

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.

RHPN1 USP38 WDR90

2.18e-046364311572484
Pubmed

The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.

FHIP1B FHIP1A

2.57e-041364232073997
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

SPON1 LAMA3 PLXNB2 MUC2

2.60e-0416764422159717
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

MDN1 HSF2BP CCAR1 SPG11 HERC1 CDC23

3.07e-0449764636774506
Pubmed

Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.

AQP12A AQP12B

3.45e-041564234540996
Pubmed

Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.

CCAR1 CDC23

3.45e-041564227030811
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

IPO5 THADA GBF1 GEMIN4

3.68e-0418364423956138
Pubmed

Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.

AQP12A AQP12B

4.45e-041764226847765
Pubmed

Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.

AQP12A AQP12B

5.59e-041964219367412
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

GBF1 SPON1 SLIT1 ADGRA2

8.00e-0422564412168954
Pubmed

GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.

DNHD1 THADA

8.23e-042364223725790
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

TDRD5 CELSR3 GEMIN4 HERC1

8.82e-0423164436597993
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DNHD1 MDN1 CCAR1 HERC1

9.25e-0423464436243803
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

GBF1 ELP2 CDC23

1.00e-0310664331024071
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ACSS1 SPG11 LRRK1

1.03e-0310764311347906
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

SLC34A3 UTRN

1.14e-032764218468998
Pubmed

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

TDRD5 H6PD

1.22e-032864225993318
Pubmed

Network organization of the human autophagy system.

IPO5 GBF1 GEMIN4 CCAR1 UTRN

1.27e-0343764520562859
Pubmed

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

CELSR3 ADGRA2

1.31e-032964215203201
Pubmed

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

JMJD1C TEX19

1.31e-032964227649575
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

IPO5 THADA MDN1 ACSS1 MRPS24 GEMIN4 HERC1 PLXNB2 CDC23

1.61e-03149664932877691
Pubmed

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

CELSR3 ADGRA2

1.70e-033364225713288
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

IPO5 MDN1 CDC23

1.76e-0312964323022380
Cytoband22q13.33

BRD1 PLXNB2 ALG12

2.10e-053864322q13.33
CytobandEnsembl 112 genes in cytogenetic band chr18q12

ELP2 ZNF396 GAREM1

4.26e-04104643chr18q12
Cytoband10q21.3

CCAR1 JMJD1C

1.04e-033464210q21.3
Cytoband1p13.2

ADORA3 TAFA3

1.90e-03466421p13.2
GeneFamilyAquaporins

AQP12A AQP12B

4.06e-0414392305
GeneFamilyWD repeat domain containing

IFT140 ELP2 WDR90 HERC1

2.38e-03262394362
GeneFamilyUbiquitin specific peptidases

USP38 USP16

6.49e-0356392366
CoexpressionNIKOLSKY_BREAST_CANCER_22Q13_AMPLICON

BRD1 PLXNB2 ALG12

8.78e-0617633M12053
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSS1 SLIT1 EEF2K RAET1E UTRN

5.47e-0617664529cda51a99100ddd2928cadc92da40f001d7e1f4
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACSS1 SLIT1 EEF2K RAET1E UTRN

5.47e-0617664501774a86d7d92f31a056b753f9844f923038003e
ToppCellfacs-Marrow-B-cells-18m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BNIP5 CD163L1 SPON1 CPED1 YIPF6

5.63e-0617764535d42b07d9c31528bf59199e361bb8a3bfbe3b75
ToppCellGlobus_pallidus-Endothelial|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LRRK1 OSMR CPED1 ADGRA2 UTRN

7.74e-06189645ad7dc9d25edd68fb624380a082c389fe7d640e7d
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

LAMA3 TMTC2 OSMR FHIP1A GAREM1

8.35e-06192645efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
Diseaseglucagon measurement, glucose tolerance test

SPON1 HERC1

6.69e-056632EFO_0004307, EFO_0008463
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

PCIF1 SPG11 JMJD1C

4.03e-0467633EFO_0008595, EFO_0020946
Diseaseacetate measurement

ACSS1 SPG11

8.32e-0420632EFO_0010112
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

GBF1 PCIF1 SPG11 JMJD1C

8.93e-04200634EFO_0004611, EFO_0020945
DiseaseC-reactive protein measurement, high density lipoprotein cholesterol measurement

PCIF1 JMJD1C

2.41e-0334632EFO_0004458, EFO_0004612
Diseasefree cholesterol in small HDL measurement

NYNRIN PCIF1

2.55e-0335632EFO_0022270
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

PCIF1 SPG11 JMJD1C

2.56e-03127633EFO_0008595, EFO_0020947
DiseaseDNA methylation

DNHD1 THADA MDN1 NLRP1 TMPRSS5 BRD1

2.74e-03656636GO_0006306
Diseasedegree of unsaturation measurement

PCIF1 JMJD1C

3.16e-0339632EFO_0022261
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

PCIF1 SPG11 JMJD1C

3.65e-03144633EFO_0004611, EFO_0020943

Protein segments in the cluster

PeptideGeneStartEntry
CSLAWVRPVEEHWTS

TDRD5

591

Q8NAT2
DDRWGHVVCALWIPE

BRD1

286

O95696
VGEPINCEAWEWLHR

ACSS1

416

Q9NUB1
THVLPLHWGAWLELC

CDC23

196

Q9UJX2
LMRLCWAWELSDLHL

AQP12A

116

Q8IXF9
DNRTCDWREITWQPH

CPED1

736

A4D0V7
VTTHRRIWLALGLCW

ADORA3

121

P0DMS8
CHLRWLLPWAQNRSL

ADGRA2

196

Q96PE1
VWHCLPTRSEWETLS

CCAR1

576

Q8IX12
RPAASLAAWLWAVLH

DNHD1

3321

Q96M86
LTRLCWAWELSDLHL

AQP12B

116

A6NM10
WGSLCDTHWDPEDAR

CD163L1

921

Q9NR16
HISIWQCLSAPWERR

CD163L1

1216

Q9NR16
WRHLPGFSDCLEWIL

ANXA2R

156

Q3ZCQ2
VVLLALAAWLRHEWA

ALG12

156

Q9BV10
IHWSSSSLPDRWIIL

RAET1E

216

Q8TD07
HWSWESELPLECATH

OSMR

96

Q99650
LRSWAWLPVWLHSLE

SLC34A3

546

Q8N130
DDWHCLRREDWLGVP

FHIP1B

281

Q8N612
LWDWSVCVPLLRSHD

MDN1

166

Q9NU22
RWRPAAWEQSHECEA

LAMA3

341

Q16787
SHLRLPWVDLDWLID

LRRK1

261

Q38SD2
DIPHSWICEKHILWL

JMJD1C

2156

Q15652
VLDWPTWHVCESEDR

HERC1

2961

Q15751
CPRAEEASHWLWSRS

PLXNB2

501

O15031
LCCLWSDWINEDHPS

MUC2

1301

Q02817
GWVLQEPSSELCLHW

NLRP1

416

Q9C000
ESWPETLVHHWLGIC

GAREM1

316

Q9H706
CVNVEEVLPHWLSWL

IPO5

986

O00410
HQPCLIRWISERGSW

MARCHF9

136

Q86YJ5
EEWHCLLKDDWLLLP

FHIP1A

266

Q05DH4
SWDCHWLSLPTAPSR

BNIP5

31

P0C671
PEELVHAGWEKCWSR

PCIF1

41

Q9H4Z3
AWWSRTLHVHERLCP

BATF2

71

Q8N1L9
LPRWASCWLVKRSHV

ITIH6

1286

Q6UXX5
EADSRTLWAHCWCPL

GBF1

1531

Q92538
LSPDRCQDWLEALHW

EEF2K

626

O00418
SVHSRIIWSCDWSPD

ELP2

666

Q6IA86
PDFCWISVHEPLIWS

CELSR3

2671

Q9NYQ7
LLLDLLWHLCSWTSQ

FAM30A

116

Q9NZY2
WAHTHLWLVDERCVP

H6PD

611

O95479
LSGPRRLTWSWCSDH

SCNN1D

21

P51172
SLCWHPTRLVLAVGW

IFT140

66

Q96RY7
THCNWIFSLLWELLP

NYNRIN

1376

Q9P2P1
SWSRELPCAWRALHT

MRPS24

16

Q96EL2
LALCLAWLWTHLTLA

TAFA3

16

Q7Z5A8
WWLLSDPDAEVCLHV

HSF2BP

261

O75031
HTLEEVWSCWIELLH

UTRN

1226

P46939
HTIPCLLSPWSEWSD

SPON1

611

Q9HCB6
LHCEWRLPSWQVALL

SVOP

111

Q8N4V2
QWHETWVSPLLFILC

THADA

521

Q6YHU6
QPCRWWRHAEVVTEL

RHPN1

561

Q8TCX5
LQCSEEPDSWHWLLV

SPG11

1446

Q96JI7
SDWLRNHCELVDWLS

WDR90

1606

Q96KV7
LRDWDLWGPLILCVT

YIPF6

86

Q96EC8
EPHCLVLSLDNWSVW

USP16

101

Q9Y5T5
LWLLLCPDTLSFDWS

TMTC2

281

Q8N394
WRWLTDSNAHRCPPT

TEX52

121

A6NCN8
RDQPRWLLVCHEGWS

TMPRSS5

126

Q9H3S3
LCRMIDWLSWPLAQH

USP38

271

Q8NB14
PHEALSRLWELCHLW

ZNF396

66

Q96N95
SRLWELCHLWLRPEV

ZNF396

71

Q96N95
CHLAWLSQWLRQRPT

SLIT1

221

O75093
LLSSLWPVVAAVWRH

TMEM239

131

Q8WW34
PWRFEELLTCSHWPS

TEX19

146

Q8NA77
SCRDWLPLEGWNHVV

GEMIN4

926

P57678