Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspremeiotic DNA replication

MCM3 MCM5 MCM7

2.00e-066973GO:0006279
GeneOntologyBiologicalProcessdouble-strand break repair via break-induced replication

MCM3 MCM5 MCM7

2.15e-0512973GO:0000727
GeneOntologyBiologicalProcessdistal tubule morphogenesis

KLHL3 WNK4

2.19e-052972GO:0072156
GeneOntologyBiologicalProcessregulation of DNA-templated DNA replication initiation

MCM3 MCM5 MCM7

4.40e-0515973GO:0030174
GeneOntologyBiologicalProcessnuclear DNA replication

MCM3 MCM5 MCM7 ILKAP

6.45e-0546974GO:0033260
GeneOntologyBiologicalProcessregulation of DNA replication

JADE2 MCM3 MCM5 MCM7 ANKRD17 ILKAP

6.86e-05147976GO:0006275
GeneOntologyBiologicalProcesscell cycle DNA replication

MCM3 MCM5 MCM7 ILKAP

9.69e-0551974GO:0044786
GeneOntologyBiologicalProcessregulation of DNA-templated DNA replication

MCM3 MCM5 MCM7 ILKAP

1.13e-0453974GO:0090329
GeneOntologyBiologicalProcessDNA unwinding involved in DNA replication

MCM3 MCM5 MCM7

1.26e-0421973GO:0006268
GeneOntologyCellularComponentMCM complex

MCM3 MCM5 MCM7

1.70e-05111003GO:0042555
GeneOntologyCellularComponentCMG complex

MCM3 MCM5 MCM7

1.70e-05111003GO:0071162
GeneOntologyCellularComponentDNA replication preinitiation complex

MCM3 MCM5 MCM7

2.93e-05131003GO:0031261
DomainG8

CEMIP2 CEMIP PKHD1

5.24e-074963PF10162
DomainG8_domain

CEMIP2 CEMIP PKHD1

5.24e-074963IPR019316
DomainG8

CEMIP2 CEMIP PKHD1

5.24e-074963PS51484
DomainG8

CEMIP2 CEMIP PKHD1

5.24e-074963SM01225
DomainMCM_N

MCM3 MCM5 MCM7

2.60e-066963IPR027925
DomainMCM_N

MCM3 MCM5 MCM7

2.60e-066963PF14551
DomainMCM_CS

MCM3 MCM5 MCM7

2.60e-066963IPR018525
DomainMCM_OB

MCM3 MCM5 MCM7

7.23e-068963IPR033762
DomainMCM_2

MCM3 MCM5 MCM7

7.23e-068963PS50051
DomainMCM_1

MCM3 MCM5 MCM7

7.23e-068963PS00847
DomainMCM_OB

MCM3 MCM5 MCM7

7.23e-068963PF17207
DomainPectin_lyase_fold/virulence

CEMIP2 CEMIP PKHD1

7.23e-068963IPR011050
DomainMCM

MCM3 MCM5 MCM7

1.08e-059963SM00350
DomainMCM_dom

MCM3 MCM5 MCM7

1.08e-059963IPR001208
DomainMCM

MCM3 MCM5 MCM7

1.08e-059963IPR031327
DomainMCM

MCM3 MCM5 MCM7

1.08e-059963PF00493
DomainFAM122

PABIR1 PABIR2

7.82e-053962IPR026716
DomainZfx_Zfy_act

ZFX ZFY

7.82e-053962PF04704
DomainTranscrp_activ_Zfx/Zfy-dom

ZFX ZFY

7.82e-053962IPR006794
DomainPectin_lyas_fold

CEMIP PKHD1

3.87e-046962IPR012334
Domain-

CEMIP PKHD1

3.87e-0469622.160.20.10
DomainThiol-ester_cl

CPAMD8 CD109

7.17e-048962PF10569
DomainMacrogloblnA2_thiol-ester-bond

CPAMD8 CD109

7.17e-048962IPR019565
DomainMacrogloblnA2_CS

CPAMD8 CD109

7.17e-048962IPR019742
DomainA2M_N_2

CPAMD8 CD109

7.17e-048962SM01359
Domain-

CPAMD8 CD109

7.17e-0489622.60.40.690
DomainA2M_recep

CPAMD8 CD109

7.17e-048962SM01361
DomainA2M

CPAMD8 CD109

7.17e-048962SM01360
DomainNA-bd_OB-fold

MCM3 MCM5 MCM7 SUPT6H

8.83e-0483964IPR012340
DomainA2M_N

CPAMD8 CD109

1.15e-0310962PF01835
DomainA2M_N

CPAMD8 CD109

1.15e-0310962IPR002890
DomainA-macroglobulin_rcpt-bd

CPAMD8 CD109

1.15e-0310962IPR009048
DomainALPHA_2_MACROGLOBULIN

CPAMD8 CD109

1.15e-0310962PS00477
DomainA2M

CPAMD8 CD109

1.15e-0310962PF00207
DomainA2M_N_2

CPAMD8 CD109

1.15e-0310962IPR011625
DomainA2M_comp

CPAMD8 CD109

1.15e-0310962IPR011626
DomainAnk_3

ANK3 TNKS

1.15e-0310962PF13606
DomainA2M_N_2

CPAMD8 CD109

1.15e-0310962PF07703
DomainA2M_recep

CPAMD8 CD109

1.15e-0310962PF07677
DomainA2M_comp

CPAMD8 CD109

1.15e-0310962PF07678
DomainMacroglobln_a2

CPAMD8 CD109

1.15e-0310962IPR001599
DomainPP2C_BS

PDP2 ILKAP

1.67e-0312962IPR000222
Domain-

CPAMD8 CD109

1.67e-03129621.50.10.20
DomainPP2C_SIG

PDP2 ILKAP

2.29e-0314962SM00331
DomainPPM_1

PDP2 ILKAP

2.63e-0315962PS01032
DomainPP2C

PDP2 ILKAP

3.38e-0317962IPR015655
DomainTerpenoid_cyclase/PrenylTrfase

CPAMD8 CD109

3.79e-0318962IPR008930
DomainRhoGAP

STARD13 ARHGAP31 ARHGAP27

4.00e-0362963SM00324
DomainP-loop_NTPase

ABCA2 SPG7 MYH13 MCM3 MCM5 MCM7 RAB3C RAB41 DHX32 KIF5C MYO15A

4.14e-038489611IPR027417
DomainRhoGAP

STARD13 ARHGAP31 ARHGAP27

4.18e-0363963PF00620
DomainPP2C

PDP2 ILKAP

4.22e-0319962PF00481
DomainRHOGAP

STARD13 ARHGAP31 ARHGAP27

4.37e-0364963PS50238
DomainRhoGAP_dom

STARD13 ARHGAP31 ARHGAP27

4.37e-0364963IPR000198
Domain-

STARD13 ARHGAP31 ARHGAP27

4.37e-03649631.10.555.10
DomainPP2Cc

PDP2 ILKAP

4.68e-0320962SM00332
DomainPPM-type_phosphatase_dom

PDP2 ILKAP

4.68e-0320962IPR001932
Domain-

PDP2 ILKAP

4.68e-03209623.60.40.10
DomainPPM_2

PDP2 ILKAP

4.68e-0320962PS51746
PathwayKEGG_MEDICUS_REFERENCE_BREAK_INDUCED_REPLICATION

MCM3 MCM5 MCM7

6.18e-068693M47840
PathwayREACTOME_UNWINDING_OF_DNA

MCM3 MCM5 MCM7

2.39e-0512693M3656
PathwayKEGG_MEDICUS_REFERENCE_TRAIP_DEPENDENT_REPLISOME_DISASSEMBLY

MCM3 MCM5 MCM7

6.00e-0516693M47862
PathwayREACTOME_INTRA_GOLGI_TRAFFIC

TRIP11 RAB41 GOLIM4 COG5

6.16e-0544694M27652
PathwayBIOCARTA_MCM_PATHWAY

MCM3 MCM5 MCM7

8.69e-0518693M6682
PathwayKEGG_MEDICUS_REFERENCE_DNA_REPLICATION_TERMINATION

MCM3 MCM5 MCM7

1.40e-0421693M47861
PathwayKEGG_MEDICUS_REFERENCE_DNA_REPLICATION_LICENSING

MCM3 MCM5 MCM7

2.11e-0424693M47857
PathwayKEGG_MEDICUS_REFERENCE_PRE_IC_FORMATION

MCM3 MCM5 MCM7

3.02e-0427693M47858
PathwayKEGG_MEDICUS_REFERENCE_ORIGIN_UNWINDING_AND_ELONGATION

MCM3 MCM5 MCM7

4.14e-0430693M47859
PathwayREACTOME_DNA_STRAND_ELONGATION

MCM3 MCM5 MCM7

5.03e-0432693M19312
PathwayREACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

MCM3 MCM5 MCM7

5.03e-0432693MM15368
PathwayREACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

MCM3 MCM5 MCM7

5.51e-0433693M9694
PathwayKEGG_DNA_REPLICATION

MCM3 MCM5 MCM7

7.14e-0436693M16853
PathwayREACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS

MCM3 MCM5 MCM7

7.14e-0436693MM14687
PathwayREACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS

MCM3 MCM5 MCM7

7.74e-0437693M11153
Pubmed

Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.

MCM3 MCM5 MCM7 ANKRD17

2.24e-097100419150984
Pubmed

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids.

MCM3 MCM5 MCM7

2.31e-083100334449552
Pubmed

The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

MCM3 MCM5 MCM7

9.21e-08410038265339
Pubmed

Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors.

MCM3 MCM5 MCM7

9.21e-084100330842144
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RANGAP1 ANK3 IQSEC2 MPDZ MCM3 TRIP11 RAB3C KIAA0319 UBR5 ANKRD17 TNKS KIF5C BAIAP2 GOLGA2 GOLGA3

1.10e-079631001528671696
Pubmed

A human MAP kinase interactome.

ANK3 JADE2 RBM4B CCDC88B HIPK3 ARHGAP31 ANKRD17 YY1AP1 BAIAP2 COG5 GOLGA2

1.64e-074861001120936779
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PABIR1 RAPGEF6 IQSEC2 MPDZ ARHGEF17 TRIP11 PABIR2 BMPR2 MAP4K1 ANKRD17 BOD1L1 KIF5C BAIAP2 WNK4

1.80e-078611001436931259
Pubmed

Pairwise interactions of the six human MCM protein subunits.

MCM3 MCM5 MCM7

4.58e-076100315236977
Pubmed

Human Mcm proteins at a replication origin during the G1 to S phase transition.

MCM3 MCM5 MCM7

4.58e-076100312364596
Pubmed

Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload.

MCM3 MCM5 MCM7

4.58e-076100321220507
Pubmed

A role for USP7 in DNA replication.

MCM3 MCM5 MCM7

4.58e-076100324190967
Pubmed

The eukaryotic Mcm2-7 replicative helicase.

MCM3 MCM5 MCM7

4.58e-076100322918583
Pubmed

In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP.

MCM3 MCM5 MCM7

4.58e-07610039099751
Pubmed

O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactions.

MCM3 MCM5 MCM7

8.01e-077100330069701
Pubmed

Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma.

MCM3 MCM5 MCM7

8.01e-077100311248027
Pubmed

Identification and characterization of a novel component of the human minichromosome maintenance complex.

MCM3 MCM5 MCM7

8.01e-077100317296731
Pubmed

Interaction of chromatin-associated Plk1 and Mcm7.

MCM3 MCM5 MCM7

8.01e-077100315654075
Pubmed

Binding of human minichromosome maintenance proteins with histone H3.

MCM3 MCM5 MCM7

8.01e-07710038798650
Pubmed

Female-biased embryonic death from inflammation induced by genomic instability.

MCM3 MCM5 MCM7

1.28e-068100330787433
Pubmed

FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling.

MCM3 MCM5 MCM7

1.28e-068100323993743
Pubmed

Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

MCM3 MCM5 MCM7

1.28e-068100316899510
Pubmed

Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.

MCM3 MCM5 MCM7

1.91e-069100310846177
Pubmed

The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.

MCM3 MCM5 MCM7

1.91e-069100325049228
Pubmed

L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.

MCM3 MCM5 MCM7

1.91e-069100321149733
Pubmed

Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa.

MCM3 MCM5 MCM7

1.91e-069100330108253
Pubmed

A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.

MCM3 MCM5 MCM7

2.73e-0610100321055985
Pubmed

Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication.

MCM3 MCM5 MCM7

2.73e-0610100316902406
Pubmed

Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.

MCM3 MCM5 MCM7

3.74e-0611100330100344
Pubmed

Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.

MCM3 MCM5 MCM7

4.98e-0612100324299456
Pubmed

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

MCM3 MCM5 MCM7

4.98e-0612100322474384
Pubmed

Timeless links replication termination to mitotic kinase activation.

MCM3 MCM5 MCM7

6.46e-0613100321573113
Pubmed

Interactions of the human MCM-BP protein with MCM complex components and Dbf4.

MCM3 MCM5 MCM7

6.46e-0613100322540012
Pubmed

Protein interaction and cellular localization of human CDC45.

MCM3 MCM5 MCM7

6.46e-0613100323364835
Pubmed

MCM complex members MCM3 and MCM7 are associated with a phenotypic spectrum from Meier-Gorlin syndrome to lipodystrophy and adrenal insufficiency.

MCM3 MCM7

8.18e-062100233654309
Pubmed

Expression of MCM-3 and MCM-7 in Primary Cutaneous T-cell Lymphomas.

MCM3 MCM7

8.18e-062100226504025
Pubmed

The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence.

IQSEC2 BAIAP2

8.18e-062100219083995
Pubmed

The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.

RBM4B RBM4

8.18e-062100218708123
Pubmed

Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study.

KLHL3 WNK4

8.18e-062100227727489
Pubmed

Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.

ZFX ZFY

8.18e-06210021691708
Pubmed

The structure of the Zfx gene on the mouse X chromosome.

ZFX ZFY

8.18e-06210028188262
Pubmed

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.

KLHL3 WNK4

8.18e-062100228743496
Pubmed

Mapping the human ZFX locus to Xp21.3 by in situ hybridization.

ZFX ZFY

8.18e-06210022497060
Pubmed

Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.

ZFX ZFY

8.18e-06210022041734
Pubmed

Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice.

ZFX ZFY

8.18e-06210028318216
Pubmed

Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.

ZFX ZFY

8.18e-06210022105457
Pubmed

Interactions of human nuclear proteins P1Mcm3 and P1Cdc46.

MCM3 MCM5

8.18e-06210027705359
Pubmed

[Expression of Zfx in mouse testicular spermatogenic cells].

ZFX ZFY

8.18e-062100238602753
Pubmed

The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts.

CEMIP2 CEMIP

8.18e-062100230241936
Pubmed

Expression, nuclear localization and interactions of human MCM/P1 proteins.

MCM5 MCM7

8.18e-06210029223437
Pubmed

Phylogenetic and molecular characterization of the splicing factor RBM4.

RBM4B RBM4

8.18e-062100223527094
Pubmed

Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation.

KLHL3 WNK4

8.18e-062100230931564
Pubmed

Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.

ZFX ZFY

8.18e-062100212716983
Pubmed

Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer.

MCM3 MCM7

8.18e-062100224324072
Pubmed

KLHL3-dependent WNK4 degradation affected by potassium through the neddylation and autophagy pathway.

KLHL3 WNK4

8.18e-062100237481568
Pubmed

Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.

ZFX ZFY

8.18e-06210029126493
Pubmed

Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.

ZFX ZFY

8.18e-062100219329779
Pubmed

Identification of a recurrent transforming UBR5-ZNF423 fusion gene in EBV-associated nasopharyngeal carcinoma.

ZNF423 UBR5

8.18e-062100223878065
Pubmed

Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.

ZFX ZFY

8.18e-06210021970799
Pubmed

Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.

ZFX ZFY

8.18e-06210028487630
Pubmed

Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and TMEM2, Strongly Predicts Shorter Survival After Resection in Pancreatic Ductal Adenocarcinoma.

CEMIP2 CEMIP

8.18e-062100236395406
Pubmed

Comparison of human ZFY and ZFX transcripts.

ZFX ZFY

8.18e-06210022308929
Pubmed

RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.

ZFX ZFY

8.18e-062100228251288
Pubmed

Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex.

GOLGA2 GOLGA3

8.18e-06210028315394
Pubmed

Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.

ZFX ZFY

8.18e-062100234324278
Pubmed

Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage.

CEMIP2 CEMIP

8.18e-062100236241903
Pubmed

Zfx mutation results in small animal size and reduced germ cell number in male and female mice.

ZFX ZFY

8.18e-06210029187153
Pubmed

Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.

ZFX ZFY

8.18e-06210022265557
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

ANK3 IQSEC2 MPDZ RAB3C UBR5 KIF5C BAIAP2

8.48e-06251100727507650
Pubmed

MCM proteins are associated with RNA polymerase II holoenzyme.

MCM3 MCM5 MCM7

1.02e-0515100310454562
Pubmed

The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells.

MCM3 MCM5 MCM7

1.02e-0515100310436018
Pubmed

MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.

MCM3 MCM5 MCM7

1.02e-0515100319696745
Pubmed

The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

MCM3 MCM5 MCM7

1.26e-0516100311095689
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

MYH13 ANK3 POR MCM3 MCM7 TRIP11 RAB3C CEMIP2 UBR5 BAIAP2 GOLGA3

1.50e-057771001135844135
Pubmed

Identification of proteins that may directly interact with human RPA.

MCM3 MCM5 MCM7

1.52e-0517100320679368
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

RANGAP1 JADE2 STRBP NT5C3A CD109 MCM3 MCM5 MCM7 URB1 POLR3B UBR5 DHX32 GEMIN6 COG5 IPO11

1.55e-0514401001530833792
Pubmed

DNA replication in eukaryotic cells.

MCM3 MCM5 MCM7

1.82e-0518100312045100
Pubmed

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

MCM3 MCM5 MCM7

2.16e-0519100315226314
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ASXL1 ZNF423 RIMS3 ARHGEF17 KIAA0319 UBR5 YY1AP1 BOD1L1

2.39e-05407100812693553
Pubmed

Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.

STRBP UBR5

2.45e-053100238280476
Pubmed

The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription.

MCM5 MCM7

2.45e-053100219318354
Pubmed

Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling.

KLHL3 WNK4

2.45e-053100230718414
Pubmed

Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.

ZFX ZFY

2.45e-05310022480529
Pubmed

A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.

MCM3 MCM7

2.45e-05310027601140
Pubmed

Genetic dissection of mammalian fertility pathways.

ZFX ZFY

2.45e-053100212479614
Pubmed

Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.

MCM3 MCM7

2.45e-053100210464337
Pubmed

X chromosome genes and premature ovarian failure.

ZFX ZFY

2.45e-053100211299520
Pubmed

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.

ZFX ZFY

2.45e-053100232406922
Pubmed

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

KLHL3 WNK4

2.45e-053100224821705
Pubmed

Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.

MCM3 MCM5

2.45e-053100227239679
Pubmed

Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas.

MCM3 MCM7

2.45e-053100225046975
Pubmed

Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins.

MCM3 MCM5

2.45e-05310027610039
Pubmed

Isolation of monochromosomal hybrids for mouse chromosomes 3, 6, 10, 12, 14, and 18.

ZFX ZFY

2.45e-05310029060403
Pubmed

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.

ZFX ZFY

2.45e-053100238310188
Pubmed

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.

KLHL3 WNK4

2.45e-053100225250572
Pubmed

RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.

RBM4B RBM4

2.45e-053100227821480
Pubmed

Targeted inhibition of the expression of both MCM5 and MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in hepatocellular carcinoma cells.

MCM5 MCM7

2.45e-053100235490917
Pubmed

Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion.

MCM3 MCM7

2.45e-053100220661220
Pubmed

Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.

CEMIP2 CEMIP

2.45e-053100237196767
Pubmed

YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.

ZFX ZFY

2.45e-05310028406471
Pubmed

A novel splicing regulator shares a nuclear import pathway with SR proteins.

RBM4B RBM4

2.45e-053100212628928
GeneFamilyMCM family

MCM3 MCM5 MCM7

4.40e-0696931085
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

CPAMD8 CD109

5.08e-0496921234
GeneFamilyRho GTPase activating proteins|BCH domain containing

STARD13 ARHGAP31 ARHGAP27

9.17e-0450693721
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PDP2 ILKAP

1.88e-0317692701
GeneFamilyAnkyrin repeat domain containing

ANKRD13D ANK3 HACE1 ANKRD17 TNKS

2.31e-03242695403
GeneFamilyZinc fingers CCHC-type|RNA binding motif containing

RBM4B RBM4

4.07e-032569274
CoexpressionZHONG_PFC_C3_ASTROCYTE

ANKRD13D ANK3 STRBP MCM7 ADCY1 RPS6KC1 KIAA0319 BMPR2 BAIAP2 GOLGA3

2.23e-063899910M39102
CoexpressionGSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN

RIMS3 PABIR2 CEMIP POLR3B SH3TC1 PKHD1 COG5

1.08e-05199997M8111
CoexpressionGSE24292_WT_VS_PPARG_KO_MACROPHAGE_DN

RAPGEF6 JADE2 NT5C3A POR INTS4 COG5 GOLGA3

1.12e-05200997M8054
CoexpressionGSE15324_ELF4_KO_VS_WT_NAIVE_CD8_TCELL_UP

ABCA2 CCDC61 RPS6KC1 BMPR2 KIF5C BAIAP2 ENOX2

1.12e-05200997M3529
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 BMPR2 WNK4 IPO11

4.36e-0618910068e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 BMPR2 WNK4 IPO11

4.36e-061891006fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell(02)_Cycling_Basal_(regeneration)|World / shred by cell type and Timepoint

RANGAP1 CD109 MCM3 MCM5 MCM7 SGO2

4.49e-06190100653f017a11ca5ebe9025558e12cedc409cab2e5aa
ToppCellControl-Lymphoid-T|World / Disease state, Lineage and Cell class

RAPGEF6 ANK3 RUNX3 CEMIP2 MAP4K1 KIF5C

4.77e-061921006253cf4d2cf88ad8c45b73779336180840bef054b
ToppCellControl-Lymphoid-T|Control / Disease state, Lineage and Cell class

RAPGEF6 ANK3 RUNX3 CEMIP2 MAP4K1 KIF5C

4.92e-061931006af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCellfrontal_cortex-Neuronal|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANK3 SCG5 RAB3C GNB5 KIF5C UNC80

5.37e-061961006de7d10da862f98894ce47244fbc992f4a12d63bb
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM5 MCM7 SLC38A10 GOLIM4 SGO2

5.86e-061991006fd1d1b95e01719e3d0a17d9d1f29717a47209d32
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM5 MCM7 SLC38A10 GOLIM4 SGO2

5.86e-06199100691882af9dc7265c9b419f4415cbcf656087a2ab3
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial|GW09 / Sample Type, Dataset, Time_group, and Cell type.

MPDZ MCM3 MCM5 MCM7

3.69e-058310047893ce9fbf34c6250dca9c265fe9b2d4cb889ade
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CRYBG2 MCM5 MCM7 URB1 SGO2

4.21e-051711005846a9acfff0bf0a9baf65dc07b7d7a9217ed6598
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 CCDC61 KLHL3 GNB5 WNK4

4.32e-051721005bc1b889ac5e07b8324ae5837eca911f9c865e959
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD109 MCM3 MCM7 SGO2 COG5

4.32e-0517210052b6cd84c946b1e800caba452ae70145ea285fec1
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 CCDC61 KLHL3 GNB5 WNK4

4.32e-051721005ba70b6110b70afb1870e8dcaf58c507b8c7d918e
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CD109 MCM3 MCM5 MCM7 GOLIM4

4.45e-051731005a55f310c533432e9e26e400026a5b47245152976
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CD109 MCM3 MCM5 MCM7 GOLIM4

4.45e-0517310059c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCG5 RIMS3 RAB3C HMCN2 KIF5C

4.57e-051741005742c73c9e090848b464323cb17579b86658c6792
ToppCellE18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCG5 RIMS3 RAB3C HMCN2 KIF5C

4.57e-0517410057fed9722e64c60843092f2ba71256e3043011ef6
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RUNX3 ZFY POLR3B SH3TC1 ENOX2

4.57e-051741005c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 CEMIP2 ARHGAP31

4.82e-051761005269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIP11 BMPR2 GOLIM4 TNKS GOLGA3

4.82e-051761005749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF423 RBP1 MCM3 MCM5 MCM7

4.82e-051761005cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

GNPTAB CEMIP2 URB1 UBR5 TNKS

4.96e-05177100582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EARS2 MCM7 KIAA0319 MAP4K1 SGO2

5.09e-0517810056178706db4a855d72abc156537604d575624df56
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EARS2 MCM7 KIAA0319 MAP4K1 SGO2

5.09e-051781005f02076ece0fa899e620971c887ad4da7f48684ed
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RUNX3 CCDC88B ADCY1 KIF5C UNC80

5.37e-0518010056ac62bf1251978c8c12e715f7b73144fca619794
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRBP ADCY1 RAB3C KIF5C UNC80

5.37e-051801005f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CERKL SCG5 ADCY1 KIF5C UNC80

5.51e-051811005cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RAPGEF6 SPG7 ANK3 UBR5 RNF207

5.51e-051811005f2315414e714ac86211546a935660c4be6e85f1b
ToppCelldroplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MCM3 MCM5 MCM7 BTNL2 SGO2

5.66e-05182100511494a66d986297b837332ee9d382b71b9f22591
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCG5 RIMS3 RAB3C KIF5C UNC80

5.66e-0518210051923932a9c60e9ec33db69ded441210d1fb07bec
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCG5 RIMS3 RAB3C KIF5C UNC80

5.66e-05182100569ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM5 MCM7 BTNL2 SGO2

5.80e-0518310056c1d7ce60e67bf1df364a4e177c351e7313eb41f
ToppCellCV-Severe-3|CV / Virus stimulation, Condition and Cluster

GNPTAB MCM3 MCM5 MCM7 FES

5.96e-0518410051c9bda00bb6efd98f68781ca06655bf6c4282f27
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCG5 RIMS3 ADCY1 RAB3C UNC80

5.96e-051841005e0e5a553fb8c0947679634396d20c2ca8455b932
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCG5 RIMS3 ADCY1 RAB3C UNC80

5.96e-051841005c3b848e1438a84b3fac8a4e40f3db478cc84d970
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-lung_neuroendocrine_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 RIMS3 ADCY1 RAB3C UNC80

6.11e-05185100530263c558ee331e0879abcf8b4c2427ff05f9fe7
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRBP ADCY1 RAB3C KIF5C UNC80

6.11e-051851005cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCelldroplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MCM3 MCM5 MCM7 PABIR2 SGO2

6.11e-05185100557c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRBP ADCY1 RAB3C KIF5C UNC80

6.11e-051851005c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Neuroendocrine|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 RIMS3 ADCY1 RAB3C UNC80

6.11e-0518510051b000ca11970db8f347eb97ff44605d562aea70a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRBP ADCY1 RAB3C KIF5C UNC80

6.43e-0518710057b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 WNK4 IPO11

6.43e-051871005d9943e65eedab73d141eae524e2411653a751705
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 WNK4 IPO11

6.43e-0518710057b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellCV-Severe-3|Severe / Virus stimulation, Condition and Cluster

CD109 MCM3 MCM5 MCM7 FES

6.43e-05187100568cb43a73945f5e252530da25613f6b3f484b4d5
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

STARD13 ZNF423 CD109 BMPR2 ARHGAP31

6.43e-051871005fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA2 ANK3 POR PDP2 SPDEF

6.43e-051871005f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 CEMIP2 ARHGAP31 WNK4 IPO11

6.59e-0518810054ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 CEMIP2 ARHGAP31 WNK4 IPO11

6.59e-051881005e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

ZNF423 CD109 RAB3C CEMIP2 KLHL3

6.59e-051881005d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STRBP ADCY1 RAB3C STX1B KIF5C

6.76e-0518910053d838da870623a6a278ddc8e6cedca85d9877e50
ToppCellNeuroendocrine-neuroendo-2-Calca|World / Class top

SCG5 RIMS3 ADCY1 RAB3C UNC80

6.76e-0518910056baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCellfacs-Marrow-KLS-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 RBP1 MCM3 MCM7 IPO11

6.93e-051901005a513c1e7df62c28128c932a68b252ee8f0255172
ToppCellIPF-Lymphoid-T|IPF / Disease state, Lineage and Cell class

RAPGEF6 ANK3 RUNX3 CEMIP2 MAP4K1

6.93e-051901005d57df208aaf7a5554899bb9107c80b443fd0cf93
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

ZNF423 CD109 RAB3C CEMIP2 ARHGAP31

6.93e-05190100578e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 CEMIP2 ARHGAP31 WNK4 IPO11

7.11e-051911005f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 CEMIP2 ARHGAP31 WNK4 IPO11

7.11e-051911005e518c598719119e60c76016c586b1520c258bbcb
ToppCelldroplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 WNK4 IPO11

7.28e-0519210050b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell5'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCG5 RIMS3 RAB3C KIF5C UNC80

7.28e-051921005307d64ef7add6a2778733e9945a1bd687feb6f44
ToppCellCOPD-Lymphoid-T|World / Disease state, Lineage and Cell class

RAPGEF6 ANK3 RUNX3 CEMIP2 MAP4K1

7.28e-051921005eb4909574fb5fc91399463523e2737095773200a
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 MCM3 MCM5 MCM7 IPO11

7.28e-05192100503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellIPF-Lymphoid-T|World / Disease state, Lineage and Cell class

RAPGEF6 ANK3 RUNX3 CEMIP2 MAP4K1

7.28e-051921005b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCellNeuroendocrine|World / Class top

SCG5 RIMS3 ADCY1 RAB3C UNC80

7.28e-0519210050199da3ef9ddb6673e9aa41f346f374838aec182
ToppCellP07-Endothelial-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RANGAP1 MCM3 MCM5 MCM7 SGO2

7.46e-0519310051e95ef29357969ee385b4717c0b5a497390ac260
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RAPGEF6 RUNX3 CEMIP2 MAP4K1 KIF5C

7.46e-0519310059c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCellP07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RANGAP1 MCM3 MCM5 MCM7 SGO2

7.46e-0519310050f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCellP03-Endothelial-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RANGAP1 MCM3 MCM5 MCM7 SGO2

7.65e-05194100522bcfb0f3f73608feb22c0847ab4d34f87aeede0
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 WNK4 IPO11

7.65e-051941005c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCellP03-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RANGAP1 MCM3 MCM5 MCM7 SGO2

7.65e-0519410055e56ce9b9fe0721be3a9e6efe1422599bb867721
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

SCG5 RIMS3 ARHGEF17 RAB3C UNC80

7.65e-051941005b6488bc3a8905e926ad298332963e1bbaf010046
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma|TCGA-Adrenal / Sample_Type by Project: Shred V9

SCG5 RIMS3 ARHGEF17 RAB3C UNC80

7.65e-0519410051e1f4139ad584f493d75a9b7f1568eca4653c5a2
ToppCelldroplet-Heart-4Chambers-21m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBP1 PABIR2 CEMIP2 WNK4 IPO11

7.83e-051951005df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell10x5'-lymph-node_spleen-Lymphocytic_NK|lymph-node_spleen / Manually curated celltypes from each tissue

ABCA2 GNPTAB RUNX3 CEMIP2 GOLIM4

8.03e-05196100593ff94fc2b2ca8bd6a6492cbc0b402daf5d63ea2
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

STARD13 CD109 CEMIP2 BMPR2 BAIAP2

8.22e-05197100530dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCG5 RIMS3 RBP1 RAB3C CEMIP2

8.22e-0519710051378bf90a4b80b8166ef352c282ce51b114ba693
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

ZNF423 CD109 CEMIP2 BMPR2 ARHGAP31

8.22e-0519710057e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCG5 RIMS3 RBP1 RAB3C KIF5C

8.42e-051981005b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK3 STRBP RAB3C KIF5C UNC80

8.42e-0519810050ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellLPS_IL1RA_TNF-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-iNKT-MAIT|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MCM3 MCM5 MCM7 RUNX3 MAP4K1

8.62e-051991005c23a53a20487a8abfeb91fa5fc9c06823dd657e9
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 ANK3 UBR5 TNKS COG5

8.62e-05199100594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells|GW13 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM7 PABIR2 GOLIM4 SGO2

8.83e-052001005d933978b55fefe52cad599b36f6b47a0c7f71f96
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MPDZ MCM3 MCM5 MCM7 SGO2

8.83e-052001005474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

ANK3 RIMS3 RBP1 TMED8 KIF5C

8.83e-052001005c92e4fc0442404481fcac623d691dae6215b852d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW13-Stem_cells-Neuroepithelial_cell|GW13 / Sample Type, Dataset, Time_group, and Cell type.

MCM3 MCM7 PABIR2 GOLIM4 SGO2

8.83e-0520010053d932765c31aef1f80a118d51e8e66c50a758dbb
ToppCell10x5'v1-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RBP1 MPDZ RAB3C CEMIP2 KLHL3

8.83e-052001005ae429f2de652cc1976e63644781197e9ce0e70c8
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Interneuron|5w / Sample Type, Dataset, Time_group, and Cell type.

ANK3 SCG5 RBP1 RAB3C KIF5C

8.83e-052001005c7e33057466915d4e2b34f2062b22d9cdffa69dc
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MPDZ MCM3 MCM5 MCM7 SGO2

8.83e-05200100501a29651e9bb64ef7666c6a61ec396eeb88b2816
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

STRBP TRIP11 ANKRD17 BOD1L1

2.64e-041381004817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY1 KLHL3 MYO15A WNK4

2.95e-041421004759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 MAP4K1

3.63e-041501004cc8361bdcaa16ab6a0d6a3684690d709bc42ff3b
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 RUNX3

3.82e-0415210043951a9f5fe164002311ed2ef7c36ae958451826b
ToppCell390C-Lymphocytic-NK_cells-NK_cell_D2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

IQSEC2 TMED8 SGO2 BAIAP2

4.11e-041551004216a240bfb82cdefc59e2f342689dbaaacb7c184
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MPDZ MCM7 TMED8 GEMIN6

4.21e-041561004895927228c93cd090303984c5be6ebfb59ed6f3a
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 CEMIP2

4.31e-0415710042c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM7 TMED8 INTS4 GOLGA3

4.31e-0415710046730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JADE2 GNPTAB RUNX3 MAP4K1

4.52e-041591004bf8ff9251bcb64b2b9d6dd93461aec97659686ec
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 PDP2

4.52e-041591004a5509f0604ef0caef5ed1af83dd89c86686c73cc
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCM3 MCM5 MCM7 RUNX3

4.52e-04159100495128a2367ff2a639b21913c0350924c174faef8
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RAPGEF6 MCM3 MCM5 MCM7

4.52e-0415910048d958d79f5eb3ab683d1245ae7f4f22a2cefbc55
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EARS2 MCM3 MCM5 MCM7

4.63e-0416010045cc1b75e3c20d83112b3aa2f3c749a6c73910a2d
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RBM4 MCM3 MCM5 MCM7

5.08e-0416410045621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
DrugThiethylperazine malate [52239-63-1]; Up 200; 6uM; HL60; HT_HG-U133A

STARD13 ABCA2 ADCY1 URB1 BMPR2 MAP4K1 KIF5C BAIAP2

2.67e-0619810086154_UP
Diseasecytotoxicity measurement, response to metformin

STX1B SH3TC1 GOLIM4

3.99e-0521943EFO_0006952, GO_1901558
DiseasePseudohypoaldosteronism type 2A

KLHL3 WNK4

6.00e-054942cv:C1840389
DiseasePseudohypoaldosteronism, type 2

KLHL3 WNK4

6.00e-054942cv:C1449844
Diseasepseudohypoaldosteronism (implicated_via_orthology)

KLHL3 WNK4

1.49e-046942DOID:4479 (implicated_via_orthology)
Diseasepseudohypoaldosteronism (is_implicated_in)

KLHL3 WNK4

2.78e-048942DOID:4479 (is_implicated_in)
DiseaseSpastic Paraplegia

SPG7 HACE1

3.56e-049942C0037772
DiseasePseudohypoaldosteronism

KLHL3 WNK4

4.44e-0410942C0033805
DiseaseHyperpotassemia and Hypertension, Familial

KLHL3 WNK4

4.44e-0410942C2713447
DiseasePseudohypoaldosteronism, Type I

KLHL3 WNK4

4.44e-0410942C0268436
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

KLHL3 WNK4

4.44e-0410942C1449843
DiseasePseudohypoaldosteronism, Type II

KLHL3 WNK4

4.44e-0410942C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

KLHL3 WNK4

4.44e-0410942C1449842
Diseaseinvasive ductal carcinoma (is_implicated_in)

RUNX3 UBR5

5.42e-0411942DOID:3008 (is_implicated_in)
Diseasemultiple sclerosis

CPAMD8 JADE2 RUNX3 CCDC88B FAM221B BTNL2 HACE1 ARHGAP27

6.28e-04594948MONDO_0005301
Diseasepsoriasis vulgaris

RUNX3 CCDC88B STX1B

9.86e-0461943EFO_1001494
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

SPG7 JADE2 ZNF423 CCDC88B CEMIP2 BMPR2 HACE1 BAIAP2 GOLGA3

1.04e-03801949EFO_0003888, EFO_0007052, MONDO_0002491
Diseaseglycochenodeoxycholate measurement

ANKRD13D CEMIP

1.32e-0317942EFO_0010490
Diseasepsoriasis, type 2 diabetes mellitus

RUNX3 CCDC88B STX1B

1.79e-0375943EFO_0000676, MONDO_0005148
DiseaseColorectal Neoplasms

CPAMD8 SCG5 CD109 SH3TC1 GNB5

1.96e-03277945C0009404
Diseaseaspartate measurement

GNPTAB COG5

2.65e-0324942EFO_0010462
Diseasecoffee consumption measurement

JADE2 POR PKHD1 FES

2.77e-03182944EFO_0006781

Protein segments in the cluster

PeptideGeneStartEntry
DLRMADGVANVEHIL

NT5C3A

281

Q9H0P0
VEHAVRVMVSGQVLE

CCDC61

16

Q9Y6R9
EAGALVMEVDHDRQV

ANKRD13D

181

Q6ZTN6
MQVLESEGRQHLEEA

CCDC88B

846

A6NC98
VHRDGVEVTEMQMEE

BTNL2

76

Q9UIR0
SEADIQRLLHGVMEQ

SCG5

36

P05408
EAAREGHEEMVALLL

ANKRD17

506

O75179
LALRVADEMDVNIGH

DHX32

126

Q7L7V1
LHIGEEIDGVDMRAE

CEMIP

476

Q8WUJ3
DGEFTHEMQVRIRQE

ASXL1

326

Q8IXJ9
REHDSQIVQIAMEAG

RC3H1

281

Q5TC82
AEAFRVIGTLEEVHM

RANGAP1

201

P46060
VHMERAEDAVEAIRG

RBM4

116

Q9BWF3
DMEDERVISTERGQH

RAB3C

146

Q96E17
VEHVRAERGDDVVIM

RAB41

126

Q5JT25
HQVAERVEALGQFVM

GNB5

81

O14775
HGLEDEMYEVRIAAV

INTS4

381

Q96HW7
RVLQEIEAHIEGMED

ARHGEF17

1266

Q96PE2
IVAELGAMEHAQAVD

POR

646

P16435
RMEENAENHIGVTEV

GNPTAB

861

Q3T906
REDDRVAIHEAMEQQ

MCM5

451

P33992
AEMVVALDALHREGI

RPS6KC1

911

Q96S38
REQHGEDGVEDMTQL

MYO15A

1216

Q9UKN7
NETGEVAVMEDHLVQ

HMCN2

1536

Q8NDA2
DHVSQVQAVERMIVG

IQSEC2

946

Q5JU85
INISVEGLHDVMTED

IPO11

871

Q9UI26
AEEIRNIHNDELMGI

ENOX2

366

Q16206
NIHNDELMGIRREEE

ENOX2

371

Q16206
HGLEMRTILADNDEV

JADE2

341

Q9NQC1
VAMRAGVLADDHLIE

PDZK1P1

46

A8MUH7
EVAKAMHREEFGAQV

FAM221B

216

A6H8Z2
AREEVQLVGASHMEQ

ZFPM1

21

Q8IX07
VQHVSDVDVEDAMGQ

HACE1

151

Q8IYU2
DVDVEDAMGQTALHV

HACE1

156

Q8IYU2
AHQAVMIGDDIVGDV

LHPP

206

Q9H008
EEGMDLINRETVHER

PABIR1

91

Q96E09
VHMERAEDAVEAIRG

RBM4B

116

Q9BQ04
GANVHLIVREVAMTD

FAAP100

761

Q0VG06
ERAQLEAHLGQVMES

GOLGA2

371

Q08379
REVAQVRQHMADLEG

GOLGA3

906

Q08378
LDDVAHVNTVMDLEG

HIPK3

471

Q9H422
AEADRTAIHEVMEQQ

MCM7

451

P33993
EGLDMVNRETAHERE

PABIR2

61

Q7Z309
EEMEQVGQAEHLEEE

GOLIM4

346

O00461
DMDRTAIHEVMEQGR

MCM3

416

P25205
DMLSNEDVVRLVVGH

PDP2

416

Q9P2J9
VEMARAGEIFEHTLQ

PXDNL

656

A1KZ92
VVEHVEAEAGAAIMN

BOD1L1

1911

Q8NFC6
GDAIEAIIITMHQED

COG5

611

Q9UP83
AEATEVDLNMRVGLH

ADCY1

386

Q08828
AERFMEENEGHIVDI

CD109

661

Q6YHK3
VDHVRRSVMVEAEGV

CPAMD8

921

Q8IZJ3
DHVEDMKAGRVVVAD

CRYBG2

1546

Q8N1P7
GEREEMQDAHVILND

ILKAP

116

Q9H0C8
LMEHDNIARFIVGDE

BMPR2

251

Q13873
VAGVQDVEVHLEDQM

CCS

36

O14618
MERAIIDTFVGHDVV

ABCA2

666

Q9BZC7
SGHEQVVEMLLDRAA

ANK3

311

Q12955
DGDLMEVASEVHIRL

CERKL

526

Q49MI3
HMGEIIDGVDMRAEV

CEMIP2

471

Q9UHN6
DVMIVAEDVEIEAHR

KLHL3

51

Q9UH77
QTVETMNEGDHRVRE

GEMIN6

66

Q8WXD5
QLEEAGRAEMLDHAV

SLC38A10

686

Q9HBR0
LVQDEVVAIHREMAA

FES

236

P07332
EHRGPVQVTQVEEDM

MAP4K1

706

Q92918
EVRSMVDVLADHAGE

RUNX3

51

Q13761
QAMVEEVRHSAAEEE

RNF207

226

Q6ZRF8
EHASLEGMRVVFQEI

RNF207

481

Q6ZRF8
HEEAQLLGGVRAVVM

STARD13

1036

Q9Y3M8
EEEGEIVMVHEHREL

RAPGEF6

391

Q8TEU7
MDVIDEGKANRHVAV

KIF5C

181

O60282
VLEQQHVGLAVDMDE

NBPF10

2126

Q6P3W6
EQQHVGLAVDMDEIE

NBPF10

2616

Q6P3W6
VLEQQHVGLAVDMDE

NBPF10

3346

Q6P3W6
HIAIMDRSGQLEVEV

RIMS3

161

Q9UJD0
IEGDELHLEMRVEGV

RBP1

111

P09455
MAADVVGDVYVLVEH

ARHGAP27

1

Q6ZUM4
ESHEVMERILDSVQG

SGO2

1091

Q562F6
AVEMGHVESQLRAVQ

SH3TC1

976

Q8TE82
SHDKRFVMEVEVDGQ

STRBP

536

Q96SI9
GAMLHVENSVEIENI

PKHD1

3156

P08F94
VAGMHEAKLEVREFV

SPG7

311

Q9UQ90
QEMQIVEELHAARVG

SWT1

341

Q5T5J6
HIDDVLDMVDVLVEG

URB1

746

O60287
NRHEVASVEGDPVIM

EARS2

206

Q5JPH6
ELGDVLFQMAEVHRQ

BAIAP2

71

Q9UQB8
HVVTVAGENRDAQML

SUPT6H

846

Q7KZ85
HRPENGEEAVTMLEE

ZSCAN30

111

Q86W11
HLMEDGEVREDGVAV

UNC80

1856

Q8N2C7
VDGMDLRDASHEQAV

MPDZ

1211

O75970
EHSLEQVQSMVVGEV

SPDEF

116

O95238
GEMIDRIEYNVEHSV

STX1B

226

P61266
VEEEMQSTIREHRDG

TNKS

1121

O95271
QGEVEDLMRDLERSH

MYH13

1426

Q9UKX3
ESDQEIVQMIGTEEH

POLR3B

246

Q9NW08
DDTVTDIAQHGLEMV

ARHGAP31

891

Q2M1Z3
EELRHMADGAREVGN

YY1AP1

386

Q9H869
GVRREEMEQLFHDDQ

TRIP11

1811

Q15643
ADGTHMDGDQIVVEV

ZFX

21

P17010
REIQIHVANHMIEEG

ZNF423

1181

Q2M1K9
GRDAAEEVAQEMVAL

WNK4

481

Q96J92
DIVMIQSEHTGAIDV

TMED8

121

Q6PL24
RVDEAMELIIAHGRE

UBR5

2441

O95071
HMDGDQIVVEIQEAV

ZFY

26

P08048
EHVRGPSAVEMENID

KIAA0319

661

Q5VV43