Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acyltransferase activity	KMT2C TRIM9 ZDHHC9 LONRF1 TRIM56 RNF146 ZFP91 RNF10 CUL9 G2E3 ZDHHC19 KAT2A RNF180 RNF126	2.75e-07	775	68	14	GO:0016746
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D KMT2A	2.09e-06	8	68	3	GO:0140945
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM9 LONRF1 TRIM56 RNF146 ZFP91 RNF10 CUL9 G2E3 RNF180 RNF126	4.30e-06	473	68	10	GO:0004842
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D KMT2A	4.46e-06	10	68	3	GO:0140999
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM9 LONRF1 TRIM56 RNF146 RNF10 CUL9 G2E3 RNF180 RNF126	4.59e-06	372	68	9	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM9 LONRF1 TRIM56 RNF146 RNF10 CUL9 G2E3 RNF180 RNF126	7.91e-06	398	68	9	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM9 LONRF1 TRIM56 RNF146 ZFP91 RNF10 CUL9 G2E3 RNF180 RNF126	8.62e-06	512	68	10	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM9 LONRF1 TRIM56 RNF146 ZFP91 RNF10 CUL9 G2E3 RNF180 RNF126	1.20e-05	532	68	10	GO:0016755
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	1.51e-05	44	68	4	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D KMT2A	4.13e-05	20	68	3	GO:0042800
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	8.50e-05	68	68	4	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	9.00e-05	69	68	4	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	1.01e-04	71	68	4	GO:0042054
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	4.22e-04	103	68	4	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	4.54e-04	105	68	4	GO:0008170
GeneOntologyMolecularFunction	zinc ion binding	ZFAND1 TRIM9 TRIM56 RNF146 NSD1 KMT2A CUL9 ZFR RNF207 ADH4	8.25e-04	891	68	10	GO:0008270
GeneOntologyMolecularFunction	histone modifying activity	KMT2C KMT2D NSD1 KMT2A KAT2A	1.10e-03	229	68	5	GO:0140993
GeneOntologyMolecularFunction	transition metal ion binding	ZFAND1 TRIM9 TRIM56 RNF146 NSD1 KMT2A CUL9 ZFR XPNPEP1 RNF207 ADH4	2.14e-03	1189	68	11	GO:0046914
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	KMT2C KMT2D NSD1 KMT2A	2.82e-03	172	68	4	GO:0008757
GeneOntologyMolecularFunction	transcription coregulator activity	SFMBT1 KMT2C KMT2D FIZ1 NR0B1 NSD1 KAT2A	2.96e-03	562	68	7	GO:0003712
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC9 ZDHHC19	3.52e-03	26	68	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC9 ZDHHC19	3.52e-03	26	68	2	GO:0019707
GeneOntologyMolecularFunction	chromatin binding	SFMBT1 CCNT1 CHD5 INSM1 NSD1 KMT2A KAT2A PHF21A	3.53e-03	739	68	8	GO:0003682
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC9 ZDHHC19	4.67e-03	30	68	2	GO:0016417
GeneOntologyCellularComponent	histone methyltransferase complex	KMT2C KMT2D NSD1 KMT2A	1.11e-04	75	69	4	GO:0035097
GeneOntologyCellularComponent	contractile actin filament bundle	SHROOM4 ABLIM1 FBLIM1 ABLIM3	4.34e-04	107	69	4	GO:0097517
GeneOntologyCellularComponent	stress fiber	SHROOM4 ABLIM1 FBLIM1 ABLIM3	4.34e-04	107	69	4	GO:0001725
GeneOntologyCellularComponent	methyltransferase complex	KMT2C KMT2D NSD1 KMT2A	4.50e-04	108	69	4	GO:0034708
GeneOntologyCellularComponent	actomyosin	SHROOM4 ABLIM1 FBLIM1 ABLIM3	6.09e-04	117	69	4	GO:0042641
GeneOntologyCellularComponent	actin filament bundle	SHROOM4 ABLIM1 FBLIM1 ABLIM3	6.29e-04	118	69	4	GO:0032432
GeneOntologyCellularComponent	MLL3/4 complex	KMT2C KMT2D	6.94e-04	12	69	2	GO:0044666
Domain	RING	RNF32 KMT2C KMT2D TRIM9 LONRF1 TRIM56 CHD5 RNF146 RNF10 NSD1 CUL9 G2E3 RNF180 RNF207 RNF126 PHF21A	1.94e-14	305	70	16	SM00184
Domain	Znf_RING	RNF32 KMT2C KMT2D TRIM9 LONRF1 TRIM56 CHD5 RNF146 RNF10 NSD1 CUL9 G2E3 RNF180 RNF207 RNF126 PHF21A	5.44e-14	326	70	16	IPR001841
Domain	-	RNF32 KMT2C KMT2D ZNF341 TRIM9 LONRF1 TRIM56 CHD5 RNF146 RNF10 NSD1 KMT2A G2E3 RNF180 RNF207 RNF126 PHF21A	5.42e-13	449	70	17	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF32 KMT2C KMT2D ZNF341 TRIM9 LONRF1 TRIM56 CHD5 RNF146 RNF10 NSD1 KMT2A G2E3 RNF180 RNF207 RNF126 PHF21A	7.72e-13	459	70	17	IPR013083
Domain	ZF_RING_2	RNF32 KMT2C KMT2D TRIM9 LONRF1 TRIM56 RNF146 RNF10 CUL9 RNF180 RNF207 RNF126	1.02e-09	298	70	12	PS50089
Domain	ZF_RING_1	RNF32 KMT2D TRIM9 LONRF1 TRIM56 RNF146 RNF10 CUL9 RNF180 RNF207 RNF126	1.04e-08	291	70	11	PS00518
Domain	PHD	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	4.13e-08	89	70	7	SM00249
Domain	Znf_PHD	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	4.82e-08	91	70	7	IPR001965
Domain	ZF_PHD_2	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	6.50e-08	95	70	7	PS50016
Domain	ZF_PHD_1	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	6.99e-08	96	70	7	PS01359
Domain	zf-C3HC4	RNF32 TRIM9 LONRF1 TRIM56 RNF146 RNF10 RNF180 RNF207 RNF126	1.45e-07	223	70	9	PF00097
Domain	Znf_RING_CS	TRIM9 LONRF1 TRIM56 RNF146 RNF10 CUL9 RNF180 RNF207	1.69e-07	163	70	8	IPR017907
Domain	AbLIM_anchor	ABLIM1 ABLIM2 ABLIM3	2.01e-07	4	70	3	PF16182
Domain	AbLIM_anchor	ABLIM1 ABLIM2 ABLIM3	2.01e-07	4	70	3	IPR032402
Domain	Znf_C3HC4_RING-type	RNF32 TRIM9 LONRF1 TRIM56 RNF10 RNF180 RNF207 RNF126	2.55e-07	172	70	8	IPR018957
Domain	Post-SET_dom	KMT2C KMT2D NSD1 KMT2A	3.18e-07	16	70	4	IPR003616
Domain	PostSET	KMT2C KMT2D NSD1 KMT2A	3.18e-07	16	70	4	SM00508
Domain	POST_SET	KMT2C KMT2D NSD1 KMT2A	3.18e-07	16	70	4	PS50868
Domain	PHD	KMT2C KMT2D CHD5 NSD1 KMT2A PHF21A	3.66e-07	75	70	6	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D CHD5 NSD1 KMT2A PHF21A	4.99e-07	79	70	6	IPR019787
Domain	FYrich_C	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	IPR003889
Domain	FYrich_N	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	IPR003888
Domain	FYRC	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	SM00542
Domain	FYRN	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	SM00541
Domain	FYRN	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	PF05964
Domain	FYRC	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	PF05965
Domain	FYRC	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	PS51543
Domain	FYRN	KMT2C KMT2D KMT2A	5.01e-07	5	70	3	PS51542
Domain	EPHD	KMT2C KMT2D KMT2A G2E3	1.26e-06	22	70	4	PS51805
Domain	Znf_FYVE_PHD	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	1.28e-06	147	70	7	IPR011011
Domain	HP	ABLIM1 ABLIM2 ABLIM3	2.79e-06	8	70	3	PS51089
Domain	-	ABLIM1 ABLIM2 ABLIM3	2.79e-06	8	70	3	1.10.950.10
Domain	VHP	ABLIM1 ABLIM2 ABLIM3	2.79e-06	8	70	3	PF02209
Domain	Villin_headpiece	ABLIM1 ABLIM2 ABLIM3	2.79e-06	8	70	3	IPR003128
Domain	VHP	ABLIM1 ABLIM2 ABLIM3	2.79e-06	8	70	3	SM00153
Domain	SET	KMT2C KMT2D NSD1 KMT2A	1.65e-05	41	70	4	PF00856
Domain	SET	KMT2C KMT2D NSD1 KMT2A	2.62e-05	46	70	4	SM00317
Domain	AT_hook	KMT2C KMT2A PHF21A	2.73e-05	16	70	3	PF02178
Domain	SET_dom	KMT2C KMT2D NSD1 KMT2A	3.66e-05	50	70	4	IPR001214
Domain	SET	KMT2C KMT2D NSD1 KMT2A	3.66e-05	50	70	4	PS50280
Domain	Zinc_finger_PHD-type_CS	CHD5 NSD1 G2E3 PHF21A	1.03e-04	65	70	4	IPR019786
Domain	DHHC	KMT2C ZDHHC9 ZDHHC19	1.09e-04	25	70	3	PS50216
Domain	Znf_DHHC_palmitoyltrfase	KMT2C ZDHHC9 ZDHHC19	1.09e-04	25	70	3	IPR001594
Domain	LIM	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.30e-04	69	70	4	PF00412
Domain	-	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.38e-04	70	70	4	2.10.110.10
Domain	AT_hook	KMT2C KMT2A PHF21A	1.38e-04	27	70	3	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C KMT2A PHF21A	1.38e-04	27	70	3	IPR017956
Domain	Znf_LIM	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.45e-04	71	70	4	IPR001781
Domain	LIM_DOMAIN_1	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.45e-04	71	70	4	PS00478
Domain	LIM_DOMAIN_2	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.45e-04	71	70	4	PS50023
Domain	LIM	ABLIM1 FBLIM1 ABLIM2 ABLIM3	1.45e-04	71	70	4	SM00132
Domain	Haem_d1	WDR19 KMT2A	2.06e-04	6	70	2	IPR011048
Domain	Znf-RING_LisH	RNF32 LONRF1 TRIM56	2.78e-04	34	70	3	IPR027370
Domain	zf-RING_UBOX	RNF32 LONRF1 TRIM56	2.78e-04	34	70	3	PF13445
Domain	Quinoprot_gluc/sorb_DH	TRIM56 EML2	8.92e-04	12	70	2	IPR011041
Domain	zf-RING_2	RNF32 RNF10 RNF126	9.77e-04	52	70	3	PF13639
Domain	HMG_box_dom	KMT2C KMT2D CHD5	1.86e-03	65	70	3	IPR009071
Domain	ZINC_FINGER_C2H2_1	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZFR ZNF513	2.39e-03	777	70	9	PS00028
Domain	zf-B_box	TRIM9 TRIM56 RNF207	2.50e-03	72	70	3	PF00643
Domain	Znf_C2H2-like	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZFR ZNF513	2.81e-03	796	70	9	IPR015880
Domain	Znf_C2H2	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZFR ZNF513	3.03e-03	805	70	9	IPR007087
Domain	ZnF_C2H2	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZFR ZNF513	3.10e-03	808	70	9	SM00355
Domain	zf-DHHC	ZDHHC9 ZDHHC19	3.33e-03	23	70	2	PF01529
Domain	ZF_BBOX	TRIM9 TRIM56 RNF207	3.37e-03	80	70	3	PS50119
Domain	Znf_B-box	TRIM9 TRIM56 RNF207	3.49e-03	81	70	3	IPR000315
Domain	-	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZNF513	3.79e-03	679	70	8	3.30.160.60
Domain	zf-C2H2	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZNF513	4.29e-03	693	70	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF777 ZNF142 ZNF341 ZNF689 INSM1 FIZ1 ZFP91 ZNF513	4.33e-03	694	70	8	IPR013087
Domain	HMGI/Y_DNA-bd_CS	KMT2C PHF21A	6.00e-03	31	70	2	IPR000637
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2C KMT2D KMT2A KAT2A	1.11e-05	42	47	4	M48018
Pathway	REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	ABLIM1 ABLIM2 ABLIM3	1.23e-05	14	47	3	M889
Pathway	WP_HISTONE_MODIFICATIONS	KMT2C KMT2D NSD1 KMT2A	6.33e-05	65	47	4	M39374
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2C KMT2D NSD1 KMT2A	8.46e-05	70	47	4	M27231
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KMT2C KMT2D NSD1 KMT2A KAT2A PHF21A	2.70e-04	272	47	6	M29619
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2D KMT2A KAT2A	2.70e-04	38	47	3	MM17073
Pathway	REACTOME_NETRIN_1_SIGNALING	ABLIM1 ABLIM2 ABLIM3	4.18e-04	44	47	3	M875
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2D NSD1 KMT2A	4.77e-04	46	47	3	MM14933
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RNF32 KMT2C IBTK ABLIM1 ZNF777 TRIM9 RNF146 NR0B1 RNF10 KMT2A ZFR KAT2A FBLIM1 RNF180 PHF21A	1.20e-11	709	71	15	22988430
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D KMT2A	8.15e-09	3	71	3	23932714
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WDR19 TUBGCP6 KMT2C IBTK ERBB2 AMIGO3 TRIM9 CHD5 RNF10 G2E3 PHF21A	1.02e-08	529	71	11	14621295
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D KMT2A	3.26e-08	4	71	3	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D KMT2A	3.26e-08	4	71	3	24081332
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C KMT2D NSD1 KMT2A KAT2A	1.18e-07	57	71	5	18022353
Pubmed	Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin.	ABLIM1 ABLIM2 ABLIM3	1.62e-07	6	71	3	17194709
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D KMT2A	2.84e-07	7	71	3	36598580
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D KMT2A	4.53e-07	8	71	3	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D KMT2A	4.53e-07	8	71	3	22266653
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D KMT2A	6.79e-07	9	71	3	22665483
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	IBTK ABLIM1 ZNF689 FIZ1 NR0B1 ZFR KAT2A FBLIM1 ABLIM2 PHF21A ZNF513	7.16e-07	808	71	11	20412781
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D KMT2A	1.77e-06	12	71	3	27563068
Pubmed	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.	KMT2D KMT2A KAT2A	2.30e-06	13	71	3	16510874
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TUBGCP6 CCNT1 ERBB2 BMPR1A TRIM56 CHD5 FIZ1 ZFP91 CUL9 KAT2A PHF21A ADH4	2.51e-06	1116	71	12	31753913
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	RNF32 TRIM9 LONRF1 RNF10 RNF126	2.53e-06	105	71	5	22493164
Pubmed	Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.	KMT2C KMT2A KAT2A	3.64e-06	15	71	3	35907431
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	4.11e-06	2	71	2	28483418
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	4.11e-06	2	71	2	34156443
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	4.11e-06	2	71	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	4.11e-06	2	71	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	4.11e-06	2	71	2	36869380
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	4.11e-06	2	71	2	26711341
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	4.11e-06	2	71	2	28967912
Pubmed	Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.	KMT2D KMT2A	4.11e-06	2	71	2	24423662
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	4.11e-06	2	71	2	25346535
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	4.11e-06	2	71	2	36601880
Pubmed	The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.	CCNT1 NSD1 KMT2A	6.51e-06	18	71	3	21030982
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2C KMT2D KMT2A	1.06e-05	21	71	3	27626377
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2C KMT2D KMT2A	1.22e-05	22	71	3	26886794
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D KMT2A	1.23e-05	3	71	2	26902498
Pubmed	MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.	KMT2D KMT2A	1.23e-05	3	71	2	23192982
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	1.23e-05	3	71	2	22183980
Pubmed	Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.	KMT2D KMT2A	1.23e-05	3	71	2	30315824
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	1.23e-05	3	71	2	21683083
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	RNF32 LONRF1 RNF146 RNF10 RNF126	1.40e-05	149	71	5	19549727
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2C ERBB2 KMT2D ZNF341 LONRF1 CHD5 NSD1 CUL9 EML2 KAT2A SLC52A3	1.42e-05	1105	71	11	35748872
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	2.46e-05	4	71	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	2.46e-05	4	71	2	34645806
Pubmed	Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.	BMPR1A KMT2A	2.46e-05	4	71	2	23736260
Pubmed	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.	KMT2D KMT2A	2.46e-05	4	71	2	22863532
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	2.46e-05	4	71	2	28398509
Pubmed	KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.	KMT2D KMT2A	2.46e-05	4	71	2	37722486
Pubmed	The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.	BMPR1A KMT2A	2.46e-05	4	71	2	30625324
Pubmed	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.	KMT2C KMT2A	2.46e-05	4	71	2	19703992
Pubmed	Evolving Catalytic Properties of the MLL Family SET Domain.	KMT2D KMT2A	4.09e-05	5	71	2	26320581
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	4.09e-05	5	71	2	31127101
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2D KMT2A	4.09e-05	5	71	2	28609655
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	4.09e-05	5	71	2	32601106
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	4.09e-05	5	71	2	26744420
Pubmed	Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.	KMT2D KMT2A	6.13e-05	6	71	2	24176642
Pubmed	GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.	KMT2D KMT2A	6.13e-05	6	71	2	34933446
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D KMT2A	6.13e-05	6	71	2	16199523
Pubmed	Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.	CCNT1 KMT2A	6.13e-05	6	71	2	21896721
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	6.13e-05	6	71	2	17021013
Pubmed	miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.	ABLIM1 ABLIM3	8.57e-05	7	71	2	22684256
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	8.57e-05	7	71	2	30604749
Pubmed	SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.	CCNT1 KMT2A	8.57e-05	7	71	2	19818711
Pubmed	Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.	KMT2D KMT2A	8.57e-05	7	71	2	19219072
Pubmed	Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.	KMT2C KMT2A	8.57e-05	7	71	2	26324722
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	8.57e-05	7	71	2	19556342
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C KMT2D KMT2A	9.49e-05	43	71	3	33472061
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C ABLIM1 TRIM9 CHD5 RNF10	9.97e-05	225	71	5	12168954
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	1.14e-04	8	71	2	21447625
Pubmed	The mutational landscape of lethal castration-resistant prostate cancer.	KMT2D KMT2A	1.14e-04	8	71	2	22722839
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	1.14e-04	8	71	2	30335158
Pubmed	Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment.	KMT2A KAT2A	1.14e-04	8	71	2	23868976
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	ASB17 ERBB2 BMPR1A TRIM56 RNF10 G2E3	1.15e-04	372	71	6	22939624
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KMT2C NSD1 KMT2A	1.40e-04	49	71	3	34368113
Pubmed	The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.	KMT2D KMT2A	1.47e-04	9	71	2	24930734
Pubmed	WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.	KMT2D KMT2A	1.47e-04	9	71	2	15960974
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	KMT2D KMT2A	1.47e-04	9	71	2	16951254
Pubmed	Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.	KMT2D KMT2A	1.47e-04	9	71	2	26691508
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2C KMT2D KMT2A	1.49e-04	50	71	3	37974198
Pubmed	A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.	CCNT1 KMT2A	1.83e-04	10	71	2	20153263
Pubmed	Expression of signaling components in embryonic eyelid epithelium.	ERBB2 BMPR1A	1.83e-04	10	71	2	24498290
Pubmed	CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis.	CCNT1 KMT2A	1.83e-04	10	71	2	22094252
Pubmed	Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.	KMT2D KAT2A	1.83e-04	10	71	2	20937768
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	2.23e-04	11	71	2	37012455
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	KMT2D KMT2A	2.23e-04	11	71	2	18082152
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2C FIZ1 NR0B1 ZFR	2.33e-04	146	71	4	23892456
Pubmed	Chromatin dynamics associated with HIV-1 Tat-activated transcription.	CCNT1 KAT2A	2.68e-04	12	71	2	19716452
Pubmed	A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.	CCNT1 KMT2C KMT2A	2.70e-04	61	71	3	20305087
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SFMBT1 KMT2C KMT2D FIZ1 NSD1 KMT2A ZFR G2E3 KAT2A PHF21A	2.88e-04	1294	71	10	30804502
Pubmed	Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.	TRIM9 LONRF1 RNF126	2.97e-04	63	71	3	23105109
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	3.16e-04	13	71	2	21502505
Pubmed	The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection.	ZFP91 RNF10	3.16e-04	13	71	2	36379255
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	3.16e-04	13	71	2	17761849
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KMT2C KMT2A	3.16e-04	13	71	2	24619213
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	3.68e-04	14	71	2	12482968
Pubmed	MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.	CCNT1 KMT2A	3.68e-04	14	71	2	20854876
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	WDR87 KAT2A	3.68e-04	14	71	2	28878358
Pubmed	Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.	KMT2D KMT2A	4.24e-04	15	71	2	14992727
Pubmed	Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.	KIAA0319 ULBP1	4.24e-04	15	71	2	20923822
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	KMT2D KMT2A	4.24e-04	15	71	2	16510875
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	4.24e-04	15	71	2	17925232
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2C KMT2A	4.84e-04	16	71	2	23870121
Pubmed	Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.	DEFB4A ADH4	4.84e-04	16	71	2	31682009
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	4.84e-04	16	71	2	24368734
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SFMBT1 KMT2A KAT2A	4.95e-04	75	71	3	25593309
Cytoband	1p36.31	CHD5 RNF207	2.12e-04	14	71	2	1p36.31
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	RNF32 KMT2C ZNF777	1.96e-03	159	71	3	chr7q36
GeneFamily	PHD finger proteins	KMT2C KMT2D CHD5 NSD1 KMT2A G2E3 PHF21A	1.46e-08	90	58	7	88
GeneFamily	Ring finger proteins	RNF32 TRIM9 LONRF1 TRIM56 RNF146 RNF10 RNF180 RNF207 RNF126	2.12e-07	275	58	9	58
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D NSD1 KMT2A	4.11e-06	34	58	4	487
GeneFamily	LIM domain containing	ABLIM1 FBLIM1 ABLIM2 ABLIM3	3.80e-05	59	58	4	1218
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC9 ZDHHC19	2.67e-03	24	58	2	76
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	4.93e-06	2	66	2	DOID:0080598 (implicated_via_orthology)
Disease	Weaver syndrome	NSD1 KMT2A	4.91e-05	5	66	2	C0265210
Disease	acute myeloid leukemia (implicated_via_orthology)	ZFP91 KMT2A	3.21e-04	12	66	2	DOID:9119 (implicated_via_orthology)
Disease	Intellectual Disability	SHROOM4 KMT2C ZNF142 ZDHHC9 NSD1 PHF21A	4.93e-04	447	66	6	C3714756
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D KMT2A	5.04e-04	69	66	3	DOID:1682 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	KMT2C ERBB2 ZFP91	5.71e-04	72	66	3	DOID:10534 (is_implicated_in)
Disease	hypertrophic cardiomyopathy	KMT2C RNF207 PHF21A	1.16e-03	92	66	3	EFO_0000538
Disease	Squamous cell carcinoma of esophagus	KMT2C KMT2D SLC52A3	1.28e-03	95	66	3	C0279626
Disease	Intrahepatic Cholangiocarcinoma	KMT2C ERBB2	1.32e-03	24	66	2	C0345905
Disease	stomach carcinoma (is_marker_for)	KMT2C ERBB2	1.32e-03	24	66	2	DOID:5517 (is_marker_for)
Disease	Extrahepatic Cholangiocarcinoma	KMT2C ERBB2	1.32e-03	24	66	2	C3805278
Disease	Cholangiocarcinoma	KMT2C ERBB2	1.55e-03	26	66	2	C0206698
Disease	Sezary Syndrome	KMT2C KMT2D	1.67e-03	27	66	2	C0036920
Disease	Carcinoma, Ovarian Epithelial	ERBB2 PHF21A	2.06e-03	30	66	2	C4721610

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACAHYKDPPFCVARC	ERBB2	586	P04626
YHPKCFVCSLCRKPF	ABLIM3	101	O94929
KCCNHPYLFPVAAVE	CHD5	991	Q8TDI0
TYHPNCFACTICKRP	ABLIM1	176	O14639
VIPLYAPLCRKCKFC	ADH4	91	P08319
TYHPDCFVCAVCRLP	ABLIM2	101	Q6H8Q1
YTPPVVACVCIHLAC	CCNT1	191	O60563
FPPRALHNCPYKCIC	AMIGO3	26	Q86WK7
AICHPVFCPRRYKQI	DEFB4A	36	O15263
CLLPLCGKFYHEECV	NSD1	1606	Q96L73
CDVPLCVVPCFEIYH	PGBD4	566	Q96DM1
CFSSEKPAAYRPCHL	ADAMTS19	1126	Q8TE59
LCYCHVPQSCDSLPR	KAT2A	296	Q92830
CHIAYFFCDIPPVLK	OR10S1	186	Q8NGN2
AICHPFRYKAVSGPC	GPR39	136	O43194
LCPFCGKCYHPELQK	KMT2C	466	Q8NEZ4
VPCDYDHCRHLQVPC	LRRN4CL	46	Q8ND94
PCHKCVLCARLEYFH	IBTK	781	Q9P2D0
NCLERCLDHAPYCPL	LONRF1	501	Q17RB8
CLDHAPYCPLCKESL	LONRF1	506	Q17RB8
PSTRYKDPCELLHLC	ASB17	246	Q8WXJ9
CSRVYHLDCLDPPLK	PHF21A	506	Q96BD5
DCHVEGTCLPPCYLV	KRTAP1-4	66	P0C5Y4
KLCCPRHYLCWSDVP	TUBGCP6	606	Q96RT7
PSTFFKYCDCIPRHL	LDLRAD1	171	Q5T700
LFPVAPCCCRPHYLF	OXA1L	41	Q15070
ARPQSCHPCCYKPEA	KCTD17	291	Q8N5Z5
LAPCFRDKCHPLYRA	NBAS	1586	A2RRP1
ALLYRCCFCGKDHPR	NR0B1	61	P51843
IGCVAPRCKRSYHFP	G2E3	91	Q7L622
FYVCSRLPCPHKIDC	GJC1	206	P36383
LPFLKCYCSGHCPDD	BMPR1A	56	P36894
PFPCLECGKFFRHEC	FIZ1	441	Q96SL8
CYPLNNHLFCKPCHV	FBLIM1	351	Q8WUP2
VYCQVCCEPFHKFCL	KMT2A	1446	Q03164
CAPIYCRRTCYHPTS	KRTAP9-7	106	A8MTY7
CYLYHPRKCLPTEFC	CUL9	1711	Q8IWT3
KVHLFSYPCCQPRAL	EML2	596	O95834
LRTEHKPCTYQQCPC	MENT	241	Q9BUN1
YPCHHIFCEPCLRTL	RNF180	446	Q86T96
RLLHAAQVFPCKYCP	INSM1	461	Q01101
DRHCAICDPLLYPSK	TAAR5	131	O14804
PLCHVQYERPCLLDC	RNF207	26	Q6ZRF8
KAAPCCPAHLAFIYT	SLC52A3	291	Q9NQ40
YAVEALPTCPFSCKC	LRTM2	31	Q8N967
YFCHCCSVEIVPRLP	RNF126	11	Q9BV68
DRPPFHACPLCRSCY	RNF32	341	Q9H0A6
LVHDPCIYCSGEICP	SHROOM4	896	Q9ULL8
HPVSLPCKHVFCYLC	RNF146	46	Q9NTX7
VCPHCDFPALYSELK	WDR19	1291	Q8NEZ3
HPPISCFYCECEEKR	OSBPL10	536	Q9BXB5
KPFRCARCPYASAHL	ZNF513	386	Q8N8E2
FPCPHCQKVFPCERY	ZNF341	566	Q9BYN7
HRCCMPYTPICIAKA	XPNPEP1	306	Q9NQW7
CYTCKIFRPPRASHC	ZDHHC9	141	Q9Y397
RCKCICPPYKENSGH	TMEM9B	41	Q9NQ34
RICSHEVPSCPICLY	RNF10	216	Q8N5U6
PSHCLPYLLDKLCCD	TEX50	51	A0A1B0GTY4
DVFYCDPCRLRCHPP	TRIM9	186	Q9C026
KPYHCPDCGRCFRRS	ZNF689	231	Q96CS4
KPPQIHYCDVCKISC	ZFR	326	Q96KR1
KCCFHRPPRTYHCPW	ZDHHC19	116	Q8WVZ1
CCPKIYFNHRCFSGP	SFMBT1	501	Q9UHJ3
HCLCYDFIITPKSRP	ULBP1	31	Q9BZM6
AVICPYCEKNFCLRH	ZFAND1	76	Q8TCF1
KYVCPHPSCGRLFRL	ZFP91	341	Q96JP5
HCHLCPYACADPSRL	ZNF142	1481	P52746
RQCIPACRKPFSYCT	THSD7B	1471	Q9C0I4
TGERPYPCTHCAKCF	ZNF777	801	Q9ULD5
KVPCRFNISCLCYDP	WDR87	106	Q6ZQQ6
PKTLPCLHTYCQDCL	TRIM56	31	Q9BRZ2
CASLVTCPICHAPYV	KMT2D	1501	O14686
RCYLVSCPHKENCEP	KIAA0319	76	Q5VV43