Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	4.64e-05	372	70	8	GO:0061630
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST1 NDST4	7.24e-05	4	70	2	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST1 NDST4	7.24e-05	4	70	2	GO:0050119
GeneOntologyMolecularFunction	low-affinity IgG receptor activity	FCGR3A FCGR3B	7.24e-05	4	70	2	GO:0019772
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	7.45e-05	398	70	8	GO:0061659
GeneOntologyMolecularFunction	IgE receptor activity	FCGR3A FCGR3B	1.80e-04	6	70	2	GO:0019767
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	2.44e-04	473	70	8	GO:0004842
GeneOntologyMolecularFunction	IgE binding	FCGR3A FCGR3B	2.52e-04	7	70	2	GO:0019863
GeneOntologyMolecularFunction	IgG receptor activity	FCGR3A FCGR3B	2.52e-04	7	70	2	GO:0019770
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	4.14e-04	512	70	8	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	5.33e-04	532	70	8	GO:0016755
GeneOntologyMolecularFunction	ferric iron binding	TH TF	6.53e-04	11	70	2	GO:0008199
GeneOntologyMolecularFunction	IgG binding	FCGR3A FCGR3B	6.53e-04	11	70	2	GO:0019864
GeneOntologyMolecularFunction	transition metal ion binding	MRE11 TH LIMS1 THRB FN1 CYP3A43 TRIM49D1 CA5B TRIP12 TF PRDM2 L3MBTL4	8.07e-04	1189	70	12	GO:0046914
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR3A FCGR3B	1.07e-03	14	70	2	GO:0019763
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST1 NDST4	1.24e-03	15	70	2	GO:0034483
GeneOntologyMolecularFunction	acyltransferase activity	KMT2C RNF148 RNF44 TRIM49D1 ASB1 ASB4 RNF128 CDC42 TRIP12	1.49e-03	775	70	9	GO:0016746
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C FAM86B2 PRDM2	1.76e-03	68	70	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C FAM86B2 PRDM2	1.83e-03	69	70	3	GO:0016278
GeneOntologyMolecularFunction	collagen binding	FN1 SPARCL1 SMAD4	2.89e-03	81	70	3	GO:0005518
GeneOntologyMolecularFunction	GPI anchor binding	FCGR3A FCGR3B	2.92e-03	23	70	2	GO:0034235
GeneOntologyMolecularFunction	phosphatidic acid binding	GRAMD1B SESTD1	3.18e-03	24	70	2	GO:0070300
GeneOntologyBiologicalProcess	perforin production	FCGR3A FCGR3B	1.10e-05	2	69	2	GO:0035944
GeneOntologyBiologicalProcess	negative regulation of cholangiocyte proliferation	LIMS1 LIMS2	3.30e-05	3	69	2	GO:1904055
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	MRE11 LIG4 LIMS1 FN1 ABCA13 MYO3B FES EPB41L5 MACF1 LMAN2 BCL11A CDC42 TF SMAD4 RAD21	3.63e-05	1366	69	15	GO:0051130
GeneOntologyCellularComponent	Fc-gamma receptor III complex	FCGR3A FCGR3B	6.42e-05	4	69	2	GO:0033001
GeneOntologyCellularComponent	meiotic cohesin complex	RAD21L1 RAD21	2.23e-04	7	69	2	GO:0030893
GeneOntologyCellularComponent	cohesin complex	RAD21L1 RAD21	5.79e-04	11	69	2	GO:0008278
GeneOntologyCellularComponent	Fc receptor complex	FCGR3A FCGR3B	6.94e-04	12	69	2	GO:0032997
Domain	Rad21/Rec8_C_eu	RAD21L1 RAD21	3.79e-05	3	67	2	IPR006909
Domain	Rad21_Rec8_N	RAD21L1 RAD21	3.79e-05	3	67	2	IPR006910
Domain	-	RAD21L1 RAD21	3.79e-05	3	67	2	1.10.10.580
Domain	Rad21_Rec8_N	RAD21L1 RAD21	3.79e-05	3	67	2	PF04825
Domain	Rad21_Rec8	RAD21L1 RAD21	3.79e-05	3	67	2	PF04824
Domain	PINCH	LIMS1 LIMS2	3.79e-05	3	67	2	IPR017351
Domain	Rad21/Rec8_C	RAD21L1 RAD21	3.79e-05	3	67	2	IPR023093
Domain	HSNSD	NDST1 NDST4	7.57e-05	4	67	2	PF12062
Domain	Heparan_SO4_deacetylase	NDST1 NDST4	7.57e-05	4	67	2	IPR021930
Domain	zf-RING_2	RNF148 RNF44 RNF128	8.60e-04	52	67	3	PF13639
Domain	PA	RNF148 RNF128	2.08e-03	19	67	2	PF02225
Domain	PA_domain	RNF148 RNF128	2.08e-03	19	67	2	IPR003137
Domain	ZF_RING_2	KMT2C RNF148 RNF44 TRIM49D1 RNF128	4.31e-03	298	67	5	PS50089
Pubmed	Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice.	LIMS1 FN1 LIMS2	4.53e-07	8	71	3	23658024
Pubmed	Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.	LIMS1 FN1 LIMS2	2.92e-06	14	71	3	19652092
Pubmed	Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG.	FCGR3A FCGR3B	4.11e-06	2	71	2	2521732
Pubmed	FCGR Genetic Variation in Two Populations From Ecuador Highlands-Extensive Copy-Number Variation, Distinctive Distribution of Functional Polymorphisms, and a Novel, Locally Common, Chimeric FCGR3B/A (CD16B/A) Gene.	FCGR3A FCGR3B	4.11e-06	2	71	2	34108956
Pubmed	Signaling via PINCH: Functions, binding partners and implications in human diseases.	LIMS1 LIMS2	4.11e-06	2	71	2	27590440
Pubmed	Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.	FN1 CDC42	4.11e-06	2	71	2	28754687
Pubmed	Single-cell analyses identify dysfunctional CD16+ CD8 T cells in smokers.	FCGR3A FCGR3B	4.11e-06	2	71	2	33163982
Pubmed	The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential.	FCGR3A FCGR3B	4.11e-06	2	71	2	23770975
Pubmed	Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.	LIMS1 LIMS2	4.11e-06	2	71	2	31723057
Pubmed	Association study of copy number variants in FCGR3A and FCGR3B gene with risk of ankylosing spondylitis in a Chinese population.	FCGR3A FCGR3B	4.11e-06	2	71	2	26494566
Pubmed	Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis.	FCGR3A FCGR3B	4.11e-06	2	71	2	22290871
Pubmed	Fcγ receptor IIIb polymorphism and use of glucocorticoids at baseline are associated with infusion reactions to infliximab in patients with rheumatoid arthritis.	FCGR3A FCGR3B	4.11e-06	2	71	2	20980704
Pubmed	Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.	FCGR3A FCGR3B	4.11e-06	2	71	2	11034564
Pubmed	LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice.	LIMS1 LIMS2	4.11e-06	2	71	2	33083097
Pubmed	Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis.	FCGR3A FCGR3B	4.11e-06	2	71	2	23917248
Pubmed	Evidence for gene recombination in FCGR3 gene variants.	FCGR3A FCGR3B	4.11e-06	2	71	2	19320901
Pubmed	Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.	FCGR3A FCGR3B	4.11e-06	2	71	2	25966632
Pubmed	The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein.	FCGR3A FCGR3B	4.11e-06	2	71	2	2967436
Pubmed	Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene.	FCGR3A FCGR3B	4.11e-06	2	71	2	8940055
Pubmed	FCGR3A and FCGR3B copy number variations are risk factors for sarcoidosis.	FCGR3A FCGR3B	4.11e-06	2	71	2	27059607
Pubmed	Low copy numbers of FCGR3A and FCGR3B associated with Chinese patients with SLE and AASV.	FCGR3A FCGR3B	4.11e-06	2	71	2	28355982
Pubmed	Association of FCGR3A and FCGR3B copy number variations with systemic lupus erythematosus and rheumatoid arthritis in Taiwanese patients.	FCGR3A FCGR3B	4.11e-06	2	71	2	25154742
Pubmed	The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.	FCGR3A FCGR3B	4.11e-06	2	71	2	7836402
Pubmed	Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells.	FCGR3A FCGR3B	4.11e-06	2	71	2	25816339
Pubmed	A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.	FCGR3A FCGR3B	4.11e-06	2	71	2	2525780
Pubmed	FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma.	FCGR3A FCGR3B	4.11e-06	2	71	2	12445195
Pubmed	Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.	FCGR3A FCGR3B	4.11e-06	2	71	2	2526846
Pubmed	Requirement for PINCH in skeletal myoblast differentiation.	LIMS1 LIMS2	4.11e-06	2	71	2	36385586
Pubmed	The loss of the CD16 B73.1/Leu11c epitope occurring in some primary immunodeficiency diseases is not associated with the FcgammaRIIIa-48L/R/H polymorphism.	FCGR3A FCGR3B	4.11e-06	2	71	2	20664961
Pubmed	B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.	FCGR3A FCGR3B	4.11e-06	2	71	2	18292508
Pubmed	Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.	LIMS1 LIMS2	4.11e-06	2	71	2	24058607
Pubmed	Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.	LIMS1 CDC42 LIMS2	7.72e-06	19	71	3	19349584
Pubmed	Association of Fcgamma receptor IIa genotype with chronic periodontitis in Caucasians.	FCGR3A FCGR3B	1.23e-05	3	71	2	15152814
Pubmed	Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.	FCGR3A FCGR3B	1.23e-05	3	71	2	25775045
Pubmed	The Fc gamma receptor genotype as a severity factor for chronic periodontitis in Japanese patients.	FCGR3A FCGR3B	1.23e-05	3	71	2	11699473
Pubmed	Associations between FCGR3A polymorphisms and susceptibility to rheumatoid arthritis: a metaanalysis.	FCGR3A FCGR3B	1.23e-05	3	71	2	18843786
Pubmed	Fc gamma receptor genes as risk markers for localized aggressive periodontitis in African-Americans.	FCGR3A FCGR3B	1.23e-05	3	71	2	12027254
Pubmed	Novel interaction of apolipoprotein(a) with beta-2 glycoprotein I mediated by the kringle IV domain.	FN1 APOH	1.23e-05	3	71	2	9269765
Pubmed	Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.	LIMS1 LIMS2	1.23e-05	3	71	2	12167643
Pubmed	Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.	FCGR3A FCGR3B	1.23e-05	3	71	2	1825220
Pubmed	Absence of association between the Fc gamma receptor IIIA-176F/V polymorphism and the severity of malaria in Thai.	FCGR3A FCGR3B	1.23e-05	3	71	2	12501257
Pubmed	Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease.	FCGR3A FCGR3B	1.23e-05	3	71	2	16133986
Pubmed	Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya.	FCGR3A FCGR3B	1.23e-05	3	71	2	28427365
Pubmed	Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains.	FCGR3A FCGR3B	1.23e-05	3	71	2	16709862
Pubmed	Polymorphisms of Fc gamma-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases.	FCGR3A FCGR3B	1.23e-05	3	71	2	11528518
Pubmed	Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease.	FCGR3A FCGR3B	1.23e-05	3	71	2	11835346
Pubmed	FcgammaRIIa, IIIa and IIIb gene polymorphisms in Behçet's disease: do they have any clinical implications?	FCGR3A FCGR3B	1.23e-05	3	71	2	19026120
Pubmed	Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease.	FCGR3A FCGR3B	1.23e-05	3	71	2	15910853
Pubmed	Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis.	FCGR3A FCGR3B	1.23e-05	3	71	2	12064825
Pubmed	Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.	FCGR3A FCGR3B	1.23e-05	3	71	2	22565545
Pubmed	Associations between FCGR2A rs1801274, FCGR3A rs396991, FCGR3B NA1/NA2 polymorphisms and periodontitis: a meta-analysis.	FCGR3A FCGR3B	1.23e-05	3	71	2	23649770
Pubmed	FcgammaRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus.	FCGR3A FCGR3B	1.23e-05	3	71	2	12121275
Pubmed	Infectious complications after chemotherapy and stem cell transplantation in multiple myeloma: implications of Fc gamma receptor and myeloperoxidase promoter polymorphisms.	FCGR3A FCGR3B	1.23e-05	3	71	2	18452102
Pubmed	Fcgamma receptor polymorphisms in relation to periodontitis.	FCGR3A FCGR3B	1.23e-05	3	71	2	12834496
Pubmed	Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis.	FCGR3A FCGR3B	1.23e-05	3	71	2	20149216
Pubmed	Fc gamma RIIa, IIIa and IIIb polymorphisms in Turkish children susceptible to recurrent infectious diseases.	FCGR3A FCGR3B	1.23e-05	3	71	2	16550341
Pubmed	Association of the Fc gamma receptor IIA-R/R131 genotype with myasthenia gravis in Dutch patients.	FCGR3A FCGR3B	1.23e-05	3	71	2	14597109
Pubmed	Risk of periodontitis in systemic lupus erythematosus is associated with Fcgamma receptor polymorphisms.	FCGR3A FCGR3B	1.23e-05	3	71	2	12710759
Pubmed	Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms.	FCGR3A FCGR3B	1.23e-05	3	71	2	21317388
Pubmed	Allelic and copy-number variations of FcγRs affect granulocyte function and susceptibility for autoimmune blistering diseases.	FCGR3A FCGR3B	1.23e-05	3	71	2	26032265
Pubmed	Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population.	FCGR3A FCGR3B	1.23e-05	3	71	2	31433132
Pubmed	Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis.	FCGR3A FCGR3B	1.23e-05	3	71	2	22167032
Pubmed	Polymorphisms of Immunoglobulin G Fc Receptors in Pediatric Guillain-Barré Syndrome.	FCGR3A FCGR3B	1.23e-05	3	71	2	27064330
Pubmed	Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms?	FCGR3A FCGR3B	1.23e-05	3	71	2	16160618
Pubmed	Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children.	FCGR3A FCGR3B	1.23e-05	3	71	2	34551786
Pubmed	Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.	FCGR3A FCGR3B	1.23e-05	3	71	2	33424858
Pubmed	FcgammaRIIA and FcgammaRIIIB mediate nuclear factor activation through separate signaling pathways in human neutrophils.	FCGR3A FCGR3B	1.23e-05	3	71	2	19342628
Pubmed	Brief research report: Effects of Pinch deficiency on cartilage homeostasis in adult mice.	LIMS1 LIMS2	1.23e-05	3	71	2	36743414
Pubmed	The role of fcgamma receptor gene polymorphism in pediatric renal transplant rejections.	FCGR3A FCGR3B	1.23e-05	3	71	2	19100392
Pubmed	HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels.	FCGR3A FCGR3B	1.23e-05	3	71	2	9743356
Pubmed	Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients.	FCGR3A FCGR3B	1.23e-05	3	71	2	17710620
Pubmed	Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis.	FCGR3A FCGR3B	1.23e-05	3	71	2	16542359
Pubmed	FCGR2A, FCGR3A, FCGR3B polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.	FCGR3A FCGR3B	1.23e-05	3	71	2	26314337
Pubmed	Consequences of loss of PINCH2 expression in mice.	LIMS1 LIMS2	1.23e-05	3	71	2	16317048
Pubmed	Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease.	FCGR3A FCGR3B	1.23e-05	3	71	2	19946017
Pubmed	Fcgamma receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms.	FCGR3A FCGR3B	1.23e-05	3	71	2	12176802
Pubmed	Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing.	MRE11 RAD21	1.23e-05	3	71	2	29917110
Pubmed	No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS.	FCGR3A FCGR3B	1.23e-05	3	71	2	12864991
Pubmed	Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms.	FCGR3A FCGR3B	1.23e-05	3	71	2	15833371
Pubmed	Fcgamma receptor IIIA polymorphism as a risk factor for acute poliomyelitis.	FCGR3A FCGR3B	1.23e-05	3	71	2	12447772
Pubmed	Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus.	FCGR3A FCGR3B	1.23e-05	3	71	2	26773105
Pubmed	Fcgamma receptor IIa, IIIa, and IIIb polymorphisms of systemic lupus erythematosus in Taiwan.	FCGR3A FCGR3B	1.23e-05	3	71	2	15194589
Pubmed	Fc-gamma receptor polymorphisms are not associated with autoimmune Addison's disease.	FCGR3A FCGR3B	1.23e-05	3	71	2	17523948
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST1 NDST4	2.46e-05	4	71	2	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST1 NDST4	2.46e-05	4	71	2	12070138
Pubmed	FCGR2B gene polymorphism rather than FCGR2A, FCGR3A and FCGR3B is associated with anti-GBM disease in Chinese.	FCGR3A FCGR3B	2.46e-05	4	71	2	19640933
Pubmed	Genetic risk factors for infection in patients with early rheumatoid arthritis.	FCGR3A FCGR3B	2.46e-05	4	71	2	15526004
Pubmed	Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.	MRE11 LIG4	2.46e-05	4	71	2	18854157
Pubmed	Pathology and protection in nephrotoxic nephritis is determined by selective engagement of specific Fc receptors.	FCGR3A FCGR3B	2.46e-05	4	71	2	16520389
Pubmed	Fcγ receptors inhibit mouse and human basophil activation.	FCGR3A FCGR3B	2.46e-05	4	71	2	22908332
Pubmed	SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development.	FN1 SMAD4	2.46e-05	4	71	2	37650555
Pubmed	A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.	LIMS1 LIMS2	2.46e-05	4	71	2	11331308
Pubmed	Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII.	FCGR3A FCGR3B	2.46e-05	4	71	2	12389094
Pubmed	Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.	FCGR3A FCGR3B	2.46e-05	4	71	2	11740730
Pubmed	Association of Fcgamma receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations.	FCGR3A FCGR3B	2.46e-05	4	71	2	14651519
Pubmed	Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B.	FCGR3A FCGR3B	2.46e-05	4	71	2	16356189
Pubmed	Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis.	FCGR3A FCGR3B	2.46e-05	4	71	2	20707220
Pubmed	Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.	FCGR3A FCGR3B	2.46e-05	4	71	2	2139735
Pubmed	Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis.	FCGR3A FCGR3B	2.46e-05	4	71	2	29720243
Pubmed	IgEb immune complexes activate macrophages through FcgammaRIV binding.	FCGR3A FCGR3B	2.46e-05	4	71	2	17558411
Interaction	H4C5 interactions	FN1 LARP7 MOV10 RAD21	5.09e-06	34	68	4	int:H4C5
GeneFamily	LIM zinc finger domain containing\|LIM domain containing	LIMS1 LIMS2	5.04e-05	4	53	2	1163
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NDST1 THRB CYP3A43 TF L3MBTL4 ACOT12	6.35e-07	192	71	6	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ABCA13 MYO3B NDST4 RAD21L1	1.57e-06	53	71	4	5fa009c9f30c77de6cece40a47da46241f1de54c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ABCA13 MYO3B NDST4 RAD21L1	1.57e-06	53	71	4	52a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCell	droplet-Spleen-nan-24m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SESTD1 FN1 FCGR3A FCGR3B FES	9.40e-06	177	71	5	5f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NDST1 THRB CYP3A43 L3MBTL4 ACOT12	1.32e-05	190	71	5	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CYP3A43 NDST4 SPARCL1 LTBP2 LIMS2	1.39e-05	192	71	5	7ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIMS1 FN1 MACF1 SPARCL1 FREM1	1.50e-05	195	71	5	1c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THRB FN1 MACF1 SPARCL1 FREM1	1.50e-05	195	71	5	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	PND10-Mesenchymal-Mesenchymal_structural\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIMS1 FN1 MACF1 SPARCL1 FREM1	1.50e-05	195	71	5	11d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIMS1 FN1 MACF1 SPARCL1 FREM1	1.50e-05	195	71	5	1f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LIMS1 FN1 MACF1 SPARCL1 FREM1	1.50e-05	195	71	5	10f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	THRB FN1 MACF1 SPARCL1 FREM1	1.58e-05	197	71	5	31a1852911bda38543916585fda34255fd62a134
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	THRB FN1 MACF1 SPARCL1 FREM1	1.58e-05	197	71	5	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MYO3B DISP3 LTBP2 FREM1	2.32e-05	104	71	4	b5ca6e589f414e549f4990fe334d4ee54829b298
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FN1 CENPL FCGR3B FES	6.26e-05	134	71	4	932b7dd5781b730dcd2ffe43f6e142e3f8630f67
ToppCell	LPS-IL1RA-Myeloid_granulocytic\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRAMD1B FCGR3A ABCA13 RNF128	1.07e-04	154	71	4	d55fb73461885e1e02061a344ff89624ef4de487
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	THNSL1 FCGR3A MYO3B TF	1.07e-04	154	71	4	ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCell	LPS-IL1RA-Myeloid_granulocytic-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRAMD1B FCGR3A ABCA13 RNF128	1.07e-04	154	71	4	43735f7c58cac51855ded486ee8d8729a1b9909e
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYN2 SPARCL1 MOV10 LIMS2	1.13e-04	156	71	4	ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	LIMS1 FN1 MACF1 FREM1	1.27e-04	161	71	4	b19f82dd98a3064581793711bb70373f18abecd9
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYO3B NDST4 DISP3 LTBP2	1.34e-04	163	71	4	8d17f44faf0549fe71a9a45f811f50d767275414
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MYO3B NDST4 DISP3 LTBP2	1.37e-04	164	71	4	08819970174a3eb4eee8e1e675075828665b845e
ToppCell	normal-na-Lymphocytic_B-B_atypical-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	BCL11A ZBTB18 PRDM2 LIMS2	1.43e-04	166	71	4	30a180b67572c3f4fb3a291f271f855e1b20005e
ToppCell	facs-Marrow-T_cells-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 FCGR3A FCGR3B FES	1.43e-04	166	71	4	fab4da2537904ad114218f720e18a600f14a00a1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RAD21L1 FREM1 L3MBTL4	1.46e-04	64	71	3	2edc3ae3e334bb04a411778e3b102b3a84a97824
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RAD21L1 FREM1 L3MBTL4	1.46e-04	64	71	3	b8aac6e83c2e5b09b55ea22ddb29940099f186e1
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Kctd12-Inhibitory_Gad1Gad2Slc17a8_Htr3a.Ktcd12_(Interneuron,__GABA/Glutamate_co-releasing?_(candidate_CGE-derived_9))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RAD21L1 FREM1 L3MBTL4	1.46e-04	64	71	3	3e3eed30abcecd3fc8d30489dca05222ac353180
ToppCell	droplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 FCGR3A FCGR3B FES	1.50e-04	168	71	4	f3b7a7df54988de77dcc7066e2fc1feb9c280b13
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 MACF1 FAM228A FREM1	1.53e-04	169	71	4	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	droplet-Spleen-nan-3m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 FCGR3A FCGR3B FES	1.53e-04	169	71	4	91cfff1ad559cc327c6bb71c98aa29f0b3642568
ToppCell	droplet-Spleen-nan-3m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 FCGR3A FCGR3B FES	1.53e-04	169	71	4	8e5e513090e86ca29fb61dfd388014774c506914
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR3A FCGR3B ABCA13 FES	1.53e-04	169	71	4	1000eaf5158596b4898bedcc802b31db76b05a48
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR3A FCGR3B ABCA13 FES	1.53e-04	169	71	4	83b854fa8fd9017df8f9207d9ced260eee98e8c1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA13 PLEKHG7 CFAP43 WDR49	1.53e-04	169	71	4	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	droplet-Spleen-nan-3m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 FCGR3A FCGR3B FES	1.53e-04	169	71	4	972618e684321060c7af2429f853a6d639e8aae8
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NDST1 FCGR3A FCGR3B FES	1.57e-04	170	71	4	81341bf4fe090af70b2091b6b2579ed08d76e22d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GRAMD1B THNSL1 TDP1 LIMS2	1.57e-04	170	71	4	12aa9bdb18f3bf6da2a25984d08fe9497e5570ed
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 MACF1 SPARCL1 FREM1	1.57e-04	170	71	4	e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	THRB FN1 SPARCL1 LIMS2	1.60e-04	171	71	4	fe0665c5ca01b0b2cc8f20d64587f0847c3d215c
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 FREM1 LARP7 RAD21	1.64e-04	172	71	4	29c8510f26527d487d0fc3543102d067cdb281a6
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SESTD1 FN1 FCGR3B FES	1.64e-04	172	71	4	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 THG1L MRPS35 RNF128	1.72e-04	174	71	4	a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-lymphocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 THG1L MRPS35 RNF128	1.72e-04	174	71	4	7f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	CYP3A43 APOH TF ACOT12	1.72e-04	174	71	4	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYO3B RAD21L1 L3MBTL4	1.75e-04	68	71	3	cfd75c373e10b3761666ccd445ba74755efeb95f
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYO3B RAD21L1 L3MBTL4	1.75e-04	68	71	3	c25fb921dc83eecdc337353894829ae6b5192353
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Bcl11b-Inhibitory_Gad1Gad2_Id2.Bcl11b_(Interneuron,_Neurogliaform2)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYO3B RAD21L1 L3MBTL4	1.75e-04	68	71	3	712f5f4d3a1e0c0db1a340332876206b93bdac31
ToppCell	P03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FN1 MACF1 SPARCL1 FREM1	1.75e-04	175	71	4	282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCell	P03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NDST1 FN1 EPB41L5 MACF1	1.79e-04	176	71	4	f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	NLRP9 SPARCL1 WDR49 FREM1	1.79e-04	176	71	4	8e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FN1 MACF1 SPARCL1 FREM1	1.79e-04	176	71	4	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	Hippocampus\|World / BrainAtlas - Mouse McCarroll V32	SYN2 BCL11A CDC42 ZBTB18	1.79e-04	176	71	4	f120a703f6d2f2d5f55eae1aea2e6382a485828f
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP3A43 APOH TF ACOT12	1.79e-04	176	71	4	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Dpy19l1_(Neuron.Gad1Gad2.Synpr-Dpy19l1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FREM1 L3MBTL4 ACOT12	1.91e-04	70	71	3	1d06fd0e20f4b3ea71a83c87736236f5c8d39f65
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Dpy19l1_(Neuron.Gad1Gad2.Synpr-Dpy19l1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FREM1 L3MBTL4 ACOT12	1.91e-04	70	71	3	e446f52534a1e8291dbb0973c6bc5094a3ebc96b
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FN1 MACF1 SPARCL1 FREM1	1.91e-04	179	71	4	b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THRB SYN2 BCL11A L3MBTL4	1.95e-04	180	71	4	b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THRB SYN2 BCL11A L3MBTL4	1.95e-04	180	71	4	f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCell	Control-Myeloid-Alveolar_macrophages\|Control / group, cell type (main and fine annotations)	FN1 FCGR3A OVCH1 WDR49	1.99e-04	181	71	4	8d2102c8c86c59a82610f26f90946b290552e666
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 MACF1 SPARCL1 LIMS2	1.99e-04	181	71	4	beb2771820956be8b190c0088ae3c4efdb53c897
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MYO3B RAD21L1 LTBP2	2.08e-04	72	71	3	0bc1df0405fe854e0364f44b9dacc39b115a9b77
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	THRB ASB4 FREM1 ACOT12	2.08e-04	183	71	4	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KMT2C ABCA13 APOH KLK13	2.17e-04	185	71	4	686ed7550c6acd18e71e0076936ec5b07389adbd
ToppCell	P03\|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FN1 MACF1 SPARCL1 FREM1	2.17e-04	185	71	4	a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	SESTD1 FN1 SPARCL1 LTBP2	2.26e-04	187	71	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	FN1 MACF1 SPARCL1 LTBP2	2.26e-04	187	71	4	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 SPARCL1 KLK13 RAD21	2.26e-04	187	71	4	173f029dcf32af008f517912f6d110a33a9e98cf
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	SESTD1 PLEKHG7 BCL11A PRDM2	2.26e-04	187	71	4	af1327559f7e01bec070881cae52834917c3da65
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPBD1P THRB EPB41L5 BCL11A	2.31e-04	188	71	4	99fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FN1 MACF1 SPARCL1 FREM1	2.31e-04	188	71	4	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	Adult-Epithelial-ciliated_cell-D231\|Adult / Lineage, Cell type, age group and donor	ABCA13 PLEKHG7 CFAP43 WDR49	2.31e-04	188	71	4	34b11f72ca73153d02edcd09b38983ad1a504659
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPBD1P THRB EPB41L5 BCL11A	2.31e-04	188	71	4	5a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell	Fibroblast-A\|World / shred on cell class and cell subclass (v4)	FN1 MACF1 SPARCL1 FREM1	2.31e-04	188	71	4	6740bed5fb8f45b6eea17041894b804214c2a4ae
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CENPBD1P THRB EPB41L5 BCL11A	2.31e-04	188	71	4	e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCA13 PLEKHG7 CFAP43 WDR49	2.35e-04	189	71	4	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FN1 MACF1 SPARCL1 FREM1	2.35e-04	189	71	4	dc5164591dea45b420798b94dda211be03daa70c
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRAMD1B FN1 DISP3 LIMS2	2.35e-04	189	71	4	b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCell	Adult-Epithelial-ciliated_cell\|Adult / Lineage, Cell type, age group and donor	ABCA13 PLEKHG7 CFAP43 WDR49	2.35e-04	189	71	4	b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCell	COVID-19-lung-Ciliated\|lung / Disease (COVID-19 only), tissue and cell type	ABCA13 PLEKHG7 CFAP43 WDR49	2.35e-04	189	71	4	27329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-fibroblast_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SYN2 MACF1 SPARCL1	2.40e-04	190	71	4	00fd993675faf53adf985b9316a18c8a33242029
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	FN1 MACF1 SPARCL1 FREM1	2.40e-04	190	71	4	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRAMD1B FN1 DISP3 LIMS2	2.40e-04	190	71	4	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	Fibroblasts-CD55+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	GRAMD1B FN1 SPARCL1 LIMS2	2.40e-04	190	71	4	b4088128f5acf53f43244c9af9fe44e033f1a57a
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	THRB MACF1 SPARCL1 L3MBTL4	2.40e-04	190	71	4	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	FN1 SPARCL1 LTBP2 FREM1	2.40e-04	190	71	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	SESTD1 PLEKHG7 BCL11A PRDM2	2.40e-04	190	71	4	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Alveolar_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 SYN2 MACF1 SPARCL1	2.40e-04	190	71	4	8cda09d761c6b504a744959d587c183f94f1beeb
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LIMS1 FN1 MACF1 SPARCL1	2.45e-04	191	71	4	509230f50568e5a8ecf08edc4d58f9e2aa96efe9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	THRB MYO3B WDR49 L3MBTL4	2.45e-04	191	71	4	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FN1 SYN2 MACF1 SPARCL1	2.45e-04	191	71	4	beb5bb42bd53bce01339da9110d374901548793c
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FN1 CYP3A43 SPARCL1 LIMS2	2.45e-04	191	71	4	adb2e3efcad02889d8229325080da5e7830fd3ae
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LIMS1 FN1 MACF1 FREM1	2.45e-04	191	71	4	e7c605b56934d1383237c1f946dbccef25d91368
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FN1 SYN2 MACF1 SPARCL1	2.45e-04	191	71	4	6609d85fd2577633dcc067507304a6f9e5865ca3
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LIMS1 FN1 MACF1 SPARCL1	2.45e-04	191	71	4	0b3dbbc35d9970d3c749aef16dda59886b960e3d
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MACF1 SPARCL1 LTBP2 FREM1	2.45e-04	191	71	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEKHG7 OVCH1 KLK13 TF	2.50e-04	192	71	4	522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCell	proximal-3-Hematologic-Platelet/Megakaryocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEKHG7 OVCH1 KLK13 TF	2.50e-04	192	71	4	f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MACF1 SPARCL1 LTBP2 FREM1	2.50e-04	192	71	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	proximal-Hematologic-Platelet/Megakaryocyte-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLEKHG7 OVCH1 KLK13 TF	2.50e-04	192	71	4	57899a905ca3e336bb7f31edc6418a2546b9891a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CENPL FCGR3B ZBTB18 ZNF850	2.50e-04	192	71	4	c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
Disease	level of low affinity immunoglobulin gamma Fc region receptor III-A in blood serum	FCGR3A FCGR3B	5.23e-06	2	68	2	OBA_2040305
Disease	Lupus Vasculitis, Central Nervous System	FCGR3A FCGR3B	1.57e-05	3	68	2	C0752332
Disease	Lupus Meningoencephalitis	FCGR3A FCGR3B	1.57e-05	3	68	2	C0752334
Disease	Neuropsychiatric Systemic Lupus Erythematosus	FCGR3A FCGR3B	1.57e-05	3	68	2	C0752335
Disease	liver cancer (implicated_via_orthology)	MRE11 ACOT12	3.13e-05	4	68	2	DOID:3571 (implicated_via_orthology)
Disease	Intellectual Disability	NDST1 KMT2C TH MACF1 BCL11A CDC42 LARP7	7.64e-05	447	68	7	C3714756
Disease	Inherited neuropathies	MRE11 SPG11 TDP1	1.09e-04	40	68	3	C0598589
Disease	low affinity immunoglobulin gamma Fc region receptor II-a/b measurement	FCGR3A FCGR3B	1.09e-04	7	68	2	EFO_0008211
Disease	plexin-B2 measurement	FCGR3A FCGR3B	1.86e-04	9	68	2	EFO_0021867
Disease	Liver Diseases, Parasitic	KMT2C SMAD4	1.86e-04	9	68	2	C0023897
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 FREM1	3.40e-04	12	68	2	DOID:3827 (implicated_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor III-B measurement	FCGR3A FCGR3B	4.68e-04	14	68	2	EFO_0008212
Disease	GDH/6PGL endoplasmic bifunctional protein measurement	APOH OVCH1	4.68e-04	14	68	2	EFO_0801619
Disease	Eye Abnormalities	NDST1 FREM1	6.96e-04	17	68	2	C0015393
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR3A FCGR3B	6.96e-04	17	68	2	EFO_0021969
Disease	glomerulonephritis (is_marker_for)	FN1 TF	8.72e-04	19	68	2	DOID:2921 (is_marker_for)
Disease	Intrahepatic Cholangiocarcinoma	KMT2C SMAD4	1.40e-03	24	68	2	C0345905
Disease	Lynch syndrome (is_implicated_in)	MRE11 SMAD4	1.40e-03	24	68	2	DOID:3883 (is_implicated_in)
Disease	Extrahepatic Cholangiocarcinoma	KMT2C SMAD4	1.40e-03	24	68	2	C3805278
Disease	breast carcinoma (is_implicated_in)	MRE11 THRB	1.52e-03	25	68	2	DOID:3459 (is_implicated_in)
Disease	antiphospholipid antibody measurement	SESTD1 APOH	1.52e-03	25	68	2	EFO_0005200
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR3A FCGR3B	1.52e-03	25	68	2	EFO_0021970
Disease	breast cancer (implicated_via_orthology)	MRE11 THRB	1.52e-03	25	68	2	DOID:1612 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	L3MBTL4 RAD21	1.64e-03	26	68	2	DOID:1319 (implicated_via_orthology)
Disease	Cholangiocarcinoma	KMT2C SMAD4	1.64e-03	26	68	2	C0206698
Disease	azoospermia (implicated_via_orthology)	NDST1 NDST4	1.77e-03	27	68	2	DOID:14227 (implicated_via_orthology)
Disease	peptide measurement	THRB ABCA13 LIMS2	2.06e-03	109	68	3	EFO_0010520
Disease	attention deficit hyperactivity disorder, autism spectrum disorder, intelligence	THRB PLEKHG7 BAG5 BCL11A CDC42	2.26e-03	398	68	5	EFO_0003756, EFO_0003888, EFO_0004337

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHCVIPKEWHKASAR	FAM228A	111	Q86W67
DSKCFPAELHLVHWN	CA5B	146	Q9Y2D0
EEITAHKHIKPWHKA	CFAP43	1081	Q8NDM7
FREFCWKPHEVLKDL	DISP3	311	Q9P2K9
EVPKCFKEHSSLAFW	APOH	321	P02749
KLFACEEHPSHKAVW	BAG5	356	Q9UL15
DFKSPLHKAAWNCDH	ASB4	251	Q9Y574
KEWLREQFCDHPLEH	ASB1	21	Q9Y576
CHPKWSEAKNYLVHA	ABCA13	331	Q86UQ4
ISHKEEVPLCIHWDI	ACOT12	331	Q8WYK0
KHPAIHCKKWADIVT	BIVM	366	Q86UB2
EKPLCPKELWHFVHQ	GRAMD1B	206	Q3KR37
AHWEKKLTKAHVFEC	RAD21L1	21	Q9H4I0
AHWDKKLTKAHVFEC	RAD21	21	O60216
VHPKWVLTAAHCLKE	KLK13	66	Q9UKR3
WCFLSELIKKHEAVH	FAM86B2	71	P0C5J1
WVHLECDKPTDHELD	KMT2C	491	Q8NEZ4
QWHVEHFVCAKCEKP	LIMS2	216	Q7Z4I7
ELVKKELCFIHHWRD	GOLGA8T	471	H3BQL2
HFWKFCEELDSEKPA	nan	56	A8MVJ9
PCFLKDWEMHVHFKV	LMAN2	106	Q12907
ILHDWPDDKVHKLLS	ASMTL	526	O95671
CPKQEHIADKLLHWR	BCL11A	121	Q9H165
KDVEDKSCPAGWHQH	FREM1	2046	Q5H8C1
HKDIWSKEKTCDRFP	NDST1	591	P52848
KHCWKLEILSGDHEQ	LARP7	516	Q4G0J3
WCEKTKHELHIPKGY	L3MBTL4	141	Q8NA19
ENVKEKWVPEITHHC	CDC42	91	P60953
HKDIWSREKTCDHLP	NDST4	581	Q9H3R1
HVEDLVPWIEDCKAK	MACF1	4916	Q9UPN3
PKACKHLWKCAVEHH	EPB41L5	306	Q9HCM4
HKAKSDRIWGEHEIC	IDI2	136	Q9BXS1
LHHDPKYWTEPEKFC	CYP3A43	401	Q9HB55
NKHDVVKPAWLLECF	LIG4	716	P49917
IHPEDAKALWDSVHK	CENPL	256	Q8N0S6
EWTCKPIAEKCFDHA	FN1	176	P02751
LPDHDIHMDICWKKV	LTBP2	1576	Q14767
WVFKEEDPIHLRCHS	FCGR3B	116	O75015
AAHWAAHTDVKPFKC	FIZ1	216	Q96SL8
TCHDLKHFWEREIGK	FAM240A	21	A0A1B0GVK7
WVFKEEDPIHLRCHS	FCGR3A	116	P08637
CVSGFPRQHEKHWKE	FAM126B	211	Q8IXS8
KHLSIHAEEWPFKCE	PRDM2	1151	Q13029
HRAVPKDKWVLNHED	FES	546	P07332
KHCEALKDFCTEWPA	MRPS35	121	P82673
LLVVDEPHADWAKCF	SYN2	116	Q92777
GHDPDWKVFLEFCKE	MOV10	926	Q9HCE1
CHWFICAPEKHIIKL	OVCH1	446	Q7RTY7
WPDLHKNELKHVKYC	SMAD4	101	Q13485
NHIFHKTCVDPWLLE	RNF128	296	Q8TEB7
QWHVEHFVCAKCEKP	LIMS1	211	P48059
DFIDLVIWGHEHECK	MRE11	236	P49959
VIWGHEHECKIAPTK	MRE11	241	P49959
CVVKPDEFWDKKVTH	SESTD1	96	Q86VW0
WLVRFKECHCLPHFK	CENPBD1P	141	B2RD01
WEKETCLHVPEHFYK	NLRP9	111	Q7RTR0
FLEKKELHEAHPWFE	SPG11	1021	Q96JI7
NAPSLKEWIDVIHKH	TDP1	331	Q9NUW8
DECKPVKWCALSHHE	TF	356	P02787
CKHFFHKACIDPWLL	RNF148	276	Q8N7C7
PLHCDIIGDAFWKEH	THG1L	276	Q9NWX6
PNKDKHITLKEWGHC	SPARCL1	636	Q14515
LPCNHEFHTKCVDKW	RNF44	396	Q7L0R7
HAVVHTREKPHACKW	ZBTB18	456	Q99592
LTAWDKPKHCPDREH	THRB	11	P10828
KPKHCPDREHDWKLV	THRB	16	P10828
QAKHWHIENCLFLPK	WDR49	516	Q8IV35
HVWPEDCEQKVSAKF	THNSL1	236	Q8IYQ7
HCPAEWAAEEHREKL	TRIM49D1	126	C9J1S8
DKTWDEVLETHHKLP	PLEKHG7	266	Q6ZR37
AKKHDELWHDGVCPS	TRIP12	1431	Q14669
KHQHNCEDPSKLWAI	ZNF438	796	Q7Z4V0
HWRIHTGDKPYECKE	ZNF850	271	A8MQ14
WFPRKVSELDKCHHL	TH	196	P07101
LLHPEKWCEEFNHFI	MYO3B	256	Q8WXR4