Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	diacylglycerol binding	UNC13B UNC13C UNC13A	2.27e-06	16	33	3	GO:0019992
GeneOntologyMolecularFunction	phorbol ester receptor activity	UNC13B UNC13C	2.65e-06	2	33	2	GO:0001565
GeneOntologyMolecularFunction	non-kinase phorbol ester receptor activity	UNC13B UNC13C	2.65e-06	2	33	2	GO:0001566
GeneOntologyMolecularFunction	syntaxin-1 binding	UNC13B UNC13C UNC13A	8.13e-06	24	33	3	GO:0017075
GeneOntologyMolecularFunction	syntaxin binding	UNC13B UNC13C UNC13A	3.97e-04	87	33	3	GO:0019905
GeneOntologyMolecularFunction	calmodulin binding	UNC13B UNC13C UNC13A RYR2	5.40e-04	230	33	4	GO:0005516
GeneOntologyMolecularFunction	SNARE binding	UNC13B UNC13C UNC13A	1.45e-03	136	33	3	GO:0000149
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity	SPOCK1 BIRC6	2.29e-03	43	33	2	GO:0004869
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	APP SPOCK1 BIRC6	3.22e-03	180	33	3	GO:0004866
GeneOntologyMolecularFunction	peptidase inhibitor activity	APP SPOCK1 BIRC6	3.59e-03	187	33	3	GO:0030414
GeneOntologyMolecularFunction	endopeptidase regulator activity	APP SPOCK1 BIRC6	4.39e-03	201	33	3	GO:0061135
GeneOntologyBiologicalProcess	dense core granule priming	UNC13B UNC13C UNC13A	1.64e-08	4	34	3	GO:0061789
GeneOntologyBiologicalProcess	presynaptic dense core vesicle exocytosis	UNC13B UNC13C UNC13A	4.87e-07	10	34	3	GO:0099525
GeneOntologyBiologicalProcess	neuronal dense core vesicle exocytosis	UNC13B UNC13C UNC13A	8.91e-07	12	34	3	GO:0099011
GeneOntologyBiologicalProcess	dense core granule exocytosis	UNC13B UNC13C UNC13A	1.84e-06	15	34	3	GO:1990504
GeneOntologyBiologicalProcess	dense core granule docking	UNC13B UNC13A	2.64e-06	2	34	2	GO:0061790
GeneOntologyBiologicalProcess	synaptic vesicle docking	UNC13B UNC13C UNC13A	2.74e-06	17	34	3	GO:0016081
GeneOntologyBiologicalProcess	calcium ion-regulated exocytosis of neurotransmitter	UNC13B UNC13C UNC13A	9.18e-06	25	34	3	GO:0048791
GeneOntologyBiologicalProcess	dense core granule localization	UNC13B UNC13C UNC13A	1.30e-05	28	34	3	GO:0032253
GeneOntologyBiologicalProcess	synaptic vesicle priming	UNC13B UNC13C UNC13A	1.78e-05	31	34	3	GO:0016082
GeneOntologyBiologicalProcess	secretory granule localization	UNC13B UNC13C UNC13A	2.36e-05	34	34	3	GO:0032252
GeneOntologyBiologicalProcess	negative regulation of synaptic plasticity	UNC13B UNC13C	3.94e-05	6	34	2	GO:0031914
GeneOntologyBiologicalProcess	vesicle docking involved in exocytosis	UNC13B UNC13C UNC13A	5.17e-05	44	34	3	GO:0006904
GeneOntologyBiologicalProcess	vesicle docking	UNC13B UNC13C UNC13A	1.67e-04	65	34	3	GO:0048278
GeneOntologyBiologicalProcess	neuromuscular junction development	UNC13B APP UNC13A	1.91e-04	68	34	3	GO:0007528
GeneOntologyBiologicalProcess	response to redox state	GLRX2 RYR2	2.37e-04	14	34	2	GO:0051775
GeneOntologyBiologicalProcess	regulation of synaptic vesicle priming	UNC13B UNC13A	2.37e-04	14	34	2	GO:0010807
GeneOntologyBiologicalProcess	establishment of organelle localization	UNC13B SPRY1 UNC13C ARHGEF2 UNC13A KNL1	2.40e-04	546	34	6	GO:0051656
GeneOntologyBiologicalProcess	calcium-ion regulated exocytosis	UNC13B UNC13C UNC13A	3.32e-04	82	34	3	GO:0017156
GeneOntologyBiologicalProcess	regulation of neuronal synaptic plasticity	UNC13B APP UNC13A	3.44e-04	83	34	3	GO:0048168
GeneOntologyBiologicalProcess	organelle localization by membrane tethering	UNC13B UNC13C UNC13A	3.69e-04	85	34	3	GO:0140056
GeneOntologyBiologicalProcess	spontaneous synaptic transmission	UNC13B APP	3.97e-04	18	34	2	GO:0098814
GeneOntologyBiologicalProcess	membrane docking	UNC13B UNC13C UNC13A	4.50e-04	91	34	3	GO:0022406
GeneOntologyBiologicalProcess	regulation of short-term neuronal synaptic plasticity	UNC13B UNC13A	5.97e-04	22	34	2	GO:0048172
GeneOntologyBiologicalProcess	developmental growth	BNC2 SPRY1 PLAA APP ERVW-1 ZNF418 UNC13A	6.05e-04	911	34	7	GO:0048589
GeneOntologyBiologicalProcess	exocytic process	UNC13B UNC13C UNC13A	7.23e-04	107	34	3	GO:0140029
GeneOntologyBiologicalProcess	growth	BNC2 SPRY1 PLAA APP ERVW-1 ZNF418 SPOCK1 UNC13A	7.24e-04	1235	34	8	GO:0040007
GeneOntologyBiologicalProcess	positive regulation of neuron migration	ARHGEF2 PLAA	7.73e-04	25	34	2	GO:2001224
GeneOntologyBiologicalProcess	neurotransmitter transport	UNC13B UNC13C APP UNC13A	8.38e-04	259	34	4	GO:0006836
GeneOntologyBiologicalProcess	synaptic vesicle cycle	UNC13B UNC13C PLAA UNC13A	8.99e-04	264	34	4	GO:0099504
GeneOntologyBiologicalProcess	organelle localization	UNC13B SPRY1 UNC13C ARHGEF2 UNC13A KNL1	9.13e-04	703	34	6	GO:0051640
GeneOntologyBiologicalProcess	cellular homeostasis	UNC13B GLRX2 PDE3B PLAA APP RYR2 SNX10	9.38e-04	981	34	7	GO:0019725
GeneOntologyCellularComponent	neuromuscular junction	UNC13B UNC13C APP SPOCK1 UNC13A	8.50e-07	112	33	5	GO:0031594
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	UNC13B UNC13C UNC13A	6.21e-06	23	33	3	GO:0098831
GeneOntologyCellularComponent	calyx of Held	UNC13B UNC13C UNC13A	2.47e-05	36	33	3	GO:0044305
GeneOntologyCellularComponent	cell cortex region	UNC13B UNC13C UNC13A	4.86e-05	45	33	3	GO:0099738
GeneOntologyCellularComponent	presynaptic active zone	UNC13B UNC13C APP UNC13A	6.97e-05	141	33	4	GO:0048786
GeneOntologyCellularComponent	terminal bouton	UNC13B UNC13C UNC13A	4.63e-04	96	33	3	GO:0043195
GeneOntologyCellularComponent	secretory vesicle	UNC13B UNC13C VWF APP SPACA4 UNC13A KNL1 SNX10	5.67e-04	1246	33	8	GO:0099503
GeneOntologyCellularComponent	synaptic vesicle	UNC13B UNC13C APP UNC13A	1.23e-03	300	33	4	GO:0008021
GeneOntologyCellularComponent	exocytic vesicle	UNC13B UNC13C APP UNC13A	1.55e-03	320	33	4	GO:0070382
GeneOntologyCellularComponent	smooth endoplasmic reticulum	APP RYR2	2.39e-03	46	33	2	GO:0005790
GeneOntologyCellularComponent	exocytic vesicle membrane	UNC13B UNC13C UNC13A	2.79e-03	179	33	3	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	UNC13B UNC13C UNC13A	2.79e-03	179	33	3	GO:0030672
GeneOntologyCellularComponent	axon terminus	UNC13B UNC13C UNC13A	4.37e-03	210	33	3	GO:0043679
GeneOntologyCellularComponent	distal axon	UNC13B UNC13C APP UNC13A	4.69e-03	435	33	4	GO:0150034
GeneOntologyCellularComponent	platelet alpha granule lumen	VWF APP	5.01e-03	67	33	2	GO:0031093
GeneOntologyCellularComponent	neuron projection terminus	UNC13B UNC13C UNC13A	5.83e-03	233	33	3	GO:0044306
GeneOntologyCellularComponent	dendritic shaft	ARHGEF2 APP	6.08e-03	74	33	2	GO:0043198
Domain	Unc-13	UNC13B UNC13C UNC13A	4.57e-09	3	32	3	IPR027080
Domain	Munc13_dom-2	UNC13B UNC13C UNC13A	4.56e-08	5	32	3	IPR014772
Domain	Membr_traf_MHD	UNC13B UNC13C UNC13A	4.56e-08	5	32	3	PF10540
Domain	DUF1041	UNC13B UNC13C UNC13A	4.56e-08	5	32	3	SM01145
Domain	MHD2	UNC13B UNC13C UNC13A	4.56e-08	5	32	3	PS51259
Domain	Munc13_subgr_dom-2	UNC13B UNC13C UNC13A	4.56e-08	5	32	3	IPR019558
Domain	DUF1041	UNC13B UNC13C UNC13A	1.59e-07	7	32	3	PF06292
Domain	Munc13_1	UNC13B UNC13C UNC13A	1.59e-07	7	32	3	IPR014770
Domain	CAPS_dom	UNC13B UNC13C UNC13A	1.59e-07	7	32	3	IPR010439
Domain	MHD1	UNC13B UNC13C UNC13A	1.59e-07	7	32	3	PS51258
Domain	C1_1	UNC13B UNC13C ARHGEF2 UNC13A	2.63e-06	57	32	4	PF00130
Domain	ZF_DAG_PE_1	UNC13B UNC13C ARHGEF2 UNC13A	4.19e-06	64	32	4	PS00479
Domain	ZF_DAG_PE_2	UNC13B UNC13C ARHGEF2 UNC13A	4.19e-06	64	32	4	PS50081
Domain	C1	UNC13B UNC13C ARHGEF2 UNC13A	4.46e-06	65	32	4	SM00109
Domain	PE/DAG-bd	UNC13B UNC13C ARHGEF2 UNC13A	4.75e-06	66	32	4	IPR002219
Domain	GLUTAREDOXIN_1	GLRX2 GRXCR1	4.25e-05	6	32	2	PS00195
Domain	TLV/ENV_coat_polyprotein	ERVW-1 ERV3-1	7.91e-05	8	32	2	IPR018154
Domain	GLUTAREDOXIN_2	GLRX2 GRXCR1	1.02e-04	9	32	2	PS51354
Domain	Glutaredoxin	GLRX2 GRXCR1	1.02e-04	9	32	2	PF00462
Domain	Glutaredoxin	GLRX2 GRXCR1	1.27e-04	10	32	2	IPR002109
Domain	TIL	VWF MUC2	1.86e-04	12	32	2	PF01826
Domain	C8	VWF MUC2	1.86e-04	12	32	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF MUC2	2.19e-04	13	32	2	IPR014853
Domain	C8	VWF MUC2	2.19e-04	13	32	2	SM00832
Domain	TIL_dom	VWF MUC2	2.55e-04	14	32	2	IPR002919
Domain	VWFD	VWF MUC2	3.36e-04	16	32	2	PS51233
Domain	VWD	VWF MUC2	3.36e-04	16	32	2	SM00216
Domain	VWF_type-D	VWF MUC2	3.36e-04	16	32	2	IPR001846
Domain	VWD	VWF MUC2	3.36e-04	16	32	2	PF00094
Domain	CTCK_1	VWF MUC2	4.28e-04	18	32	2	PS01185
Domain	VWC_out	VWF MUC2	4.78e-04	19	32	2	SM00215
Domain	CT	VWF MUC2	6.43e-04	22	32	2	SM00041
Domain	Cys_knot_C	VWF MUC2	8.32e-04	25	32	2	IPR006207
Domain	CTCK_2	VWF MUC2	8.32e-04	25	32	2	PS01225
Domain	C2	UNC13B UNC13C UNC13A	1.44e-03	131	32	3	PF00168
Domain	C2	UNC13B UNC13C UNC13A	1.64e-03	137	32	3	SM00239
Domain	VWFC_1	VWF MUC2	1.73e-03	36	32	2	PS01208
Domain	C2	UNC13B UNC13C UNC13A	1.82e-03	142	32	3	PS50004
Domain	VWC	VWF MUC2	1.92e-03	38	32	2	SM00214
Domain	VWFC_2	VWF MUC2	1.92e-03	38	32	2	PS50184
Domain	-	UNC13B UNC13C UNC13A	2.04e-03	148	32	3	2.60.40.150
Domain	VWF_dom	VWF MUC2	2.35e-03	42	32	2	IPR001007
Domain	C2_dom	UNC13B UNC13C UNC13A	2.73e-03	164	32	3	IPR000008
Domain	VWA	VWF COCH	4.13e-03	56	32	2	PF00092
Domain	-	VWF COCH	7.11e-03	74	32	2	3.40.50.410
Domain	VWFA	VWF COCH	8.67e-03	82	32	2	PS50234
Domain	VWA	VWF COCH	9.08e-03	84	32	2	SM00327
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	UNC13B UNC13C UNC13A	8.56e-05	51	24	3	M39457
Pubmed	The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.	UNC13B UNC13C UNC13A	8.54e-10	3	34	3	23658173
Pubmed	Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.	UNC13B UNC13C UNC13A	8.54e-10	3	34	3	33105896
Pubmed	Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.	UNC13B UNC13C UNC13A	8.54e-10	3	34	3	22966208
Pubmed	Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.	UNC13B UNC13C UNC13A	8.54e-10	3	34	3	15988013
Pubmed	Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.	UNC13B APP UNC13A	3.41e-09	4	34	3	15123597
Pubmed	An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.	UNC13B UNC13C UNC13A	8.52e-09	5	34	3	34706221
Pubmed	Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.	UNC13B UNC13C UNC13A	8.52e-09	5	34	3	26575293
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	UNC13B UNC13C UNC13A	2.98e-08	7	34	3	36398873
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	UNC13B UNC13C UNC13A	4.76e-08	8	34	3	25609709
Pubmed	Molecular and functional architecture of striatal dopamine release sites.	UNC13B UNC13C UNC13A	1.40e-07	11	34	3	34767769
Pubmed	Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.	UNC13B UNC13A	9.28e-07	2	34	2	12070347
Pubmed	Regulation of insulin exocytosis by Munc13-1.	UNC13B UNC13A	9.28e-07	2	34	2	12871971
Pubmed	Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.	UNC13B UNC13A	9.28e-07	2	34	2	17561838
Pubmed	Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.	UNC13B UNC13A	9.28e-07	2	34	2	23070049
Pubmed	Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.	APP RYR2	9.28e-07	2	34	2	32966798
Pubmed	The complete cDNA sequence and structural polymorphism of the polypeptide chain of porcine submaxillary mucin.	VWF MUC2	9.28e-07	2	34	2	9407109
Pubmed	Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.	UNC13B UNC13A	9.28e-07	2	34	2	28489077
Pubmed	Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.	UNC13B UNC13A	9.28e-07	2	34	2	10440375
Pubmed	Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.	UNC13B UNC13A	9.28e-07	2	34	2	22066784
Pubmed	Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.	UNC13B UNC13A	9.28e-07	2	34	2	32187536
Pubmed	Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.	UNC13B UNC13A	9.28e-07	2	34	2	28772123
Pubmed	Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.	UNC13B UNC13A	9.28e-07	2	34	2	17267576
Pubmed	Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.	UNC13B UNC13A	9.28e-07	2	34	2	22814762
Pubmed	Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.	UNC13B UNC13A	9.28e-07	2	34	2	28426965
Pubmed	A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.	UNC13B UNC13A	9.28e-07	2	34	2	35613050
Pubmed	Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.	UNC13B UNC13A	9.28e-07	2	34	2	23770256
Pubmed	Membrane bridging by Munc13-1 is crucial for neurotransmitter release.	UNC13B UNC13A	9.28e-07	2	34	2	30816091
Pubmed	Munc13-independent vesicle priming at mouse photoreceptor ribbon synapses.	UNC13B UNC13C	9.28e-07	2	34	2	22674279
Pubmed	A common molecular basis for membrane docking and functional priming of synaptic vesicles.	UNC13B UNC13A	9.28e-07	2	34	2	19558619
Pubmed	Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.	UNC13B UNC13A	9.28e-07	2	34	2	18701688
Pubmed	Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.	UNC13B UNC13A	9.28e-07	2	34	2	31851910
Pubmed	Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.	UNC13B UNC13A	9.28e-07	2	34	2	11832228
Pubmed	Munc13 controls the location and efficiency of dense-core vesicle release in neurons.	UNC13B UNC13A	9.28e-07	2	34	2	23229896
Pubmed	Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.	UNC13B UNC13A	9.28e-07	2	34	2	11792326
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	UNC13B UNC13C UNC13A	2.19e-06	26	34	3	17124501
Pubmed	Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.	UNC13B UNC13A	2.78e-06	3	34	2	37343100
Pubmed	The role of syncytins in human reproduction and reproductive organ cancers.	ERVW-1 ERV3-1	2.78e-06	3	34	2	27486264
Pubmed	Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.	UNC13B UNC13A	2.78e-06	3	34	2	17639022
Pubmed	Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.	APP RYR2	2.78e-06	3	34	2	28476886
Pubmed	Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles.	ERVW-1 ERV3-1	2.78e-06	3	34	2	26992684
Pubmed	The synaptic vesicle cycle.	UNC13B UNC13C UNC13A	3.77e-06	31	34	3	15217342
Pubmed	Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.	UNC13B UNC13A	5.56e-06	4	34	2	10488064
Pubmed	Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.	UNC13B UNC13A	5.56e-06	4	34	2	19996097
Pubmed	ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.	UNC13B UNC13A	5.56e-06	4	34	2	28264913
Pubmed	A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.	SPRY1 RYR2	5.56e-06	4	34	2	33664309
Pubmed	A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.	UNC13B UNC13A	9.26e-06	5	34	2	32755572
Pubmed	RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.	UNC13B UNC13A	9.26e-06	5	34	2	22248876
Pubmed	Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.	UNC13B UNC13A	9.26e-06	5	34	2	33139401
Pubmed	Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.	UNC13B UNC13A	1.39e-05	6	34	2	28635948
Pubmed	Tagging genes with cassette-exchange sites.	BNC2 ARHGEF2 PLAA CHM BIRC6	1.78e-05	335	34	5	15741177
Pubmed	SNAREs and traffic.	UNC13B UNC13A	1.94e-05	7	34	2	15893389
Pubmed	Syncytins expressed in human placental trophoblast.	ERVW-1 ERV3-1	2.59e-05	8	34	2	33504453
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVW-1 ERV3-1	4.15e-05	10	34	2	12970426
Pubmed	SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.	UNC13B UNC13A	4.15e-05	10	34	2	21040848
Pubmed	The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.	UNC13B UNC13A	5.07e-05	11	34	2	25374362
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVW-1 ERV3-1	6.08e-05	12	34	2	14557543
Pubmed	Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.	APP SPOCK1	1.41e-04	18	34	2	12684764
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	ARHGEF2 UNC13A	1.93e-04	21	34	2	22959728
Pubmed	Lipid signatures reflect the function of the murine primary placentation†.	VWF ERVW-1	2.12e-04	22	34	2	34850819
Interaction	GPR15 interactions	GPR15 APP	7.32e-06	3	32	2	int:GPR15
Interaction	DIRAS1 interactions	UNC13B APP UNC13A	1.43e-05	30	32	3	int:DIRAS1
Interaction	UBXN10 interactions	UNC13B APP UNC13A	4.00e-05	42	32	3	int:UBXN10
GeneFamily	UNC13 homologs	UNC13B UNC13C UNC13A	1.19e-08	4	27	3	836
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	UNC13B SPRY1 PDE3B APP ADAMTSL2	4.14e-07	200	34	5	abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 SPRY1 PDE3B RYR2 ADAMTSL2	4.14e-07	200	34	5	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 UNC13C TMEM61 SPOCK1	7.42e-06	165	34	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 UNC13C TMEM61 SPOCK1	7.60e-06	166	34	4	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 UNC13C TMEM61 SPOCK1	7.97e-06	168	34	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	BNC2 VWF COCH TMEM61	8.75e-06	172	34	4	dd3a23dc78dc6939f41126f8d7bd23a2e4713647
ToppCell	Nasal_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	BNC2 VWF COCH TMEM61	8.75e-06	172	34	4	04fabb40fa9357d8902f3b04adc15231626cd9f8
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	UNC13C VWF TMEM61 SPOCK1	1.02e-05	179	34	4	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	BNC2 PDE3B SPOCK1 ADAMTSL2	1.07e-05	181	34	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BNC2 SPRY1 VWF SPOCK1	1.09e-05	182	34	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	NS-critical-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 UNC13C TMEM61 SPOCK1	1.12e-05	183	34	4	ba43bca2b45be1008eebd3f033cecb061fb3a966
ToppCell	critical-Epithelial-Ionocyte\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 UNC13C TMEM61 SPOCK1	1.14e-05	184	34	4	58d36577eff814d46d72f031f3533d71549e3d6e
ToppCell	critical-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 UNC13C TMEM61 SPOCK1	1.29e-05	190	34	4	05a2c3549b68f49081723bf35db14974274419d5
ToppCell	PSB-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 UNC13C COCH TMEM61	1.32e-05	191	34	4	8f4637e801554e2343b974fe7794f01dd2151418
ToppCell	LV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	BNC2 SPRY1 PDE3B SPOCK1	1.32e-05	191	34	4	d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	BNC2 SPRY1 VWF SPOCK1	1.35e-05	192	34	4	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	distal-Hematologic-B_cell-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC13C GPR15 COCH TREML2	1.38e-05	193	34	4	202dc5ec2437602c15658074728c5f5aeeab0466
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BNC2 UNC13C PDE3B RYR2	1.40e-05	194	34	4	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	BNC2 SPRY1 PDE3B SPOCK1	1.40e-05	194	34	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	distal-2-Hematologic-B_cell\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	UNC13C GPR15 COCH TREML2	1.46e-05	196	34	4	2587b5d83fb4f1c4a69894aa0f5f7cb3898faa09
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	BNC2 PDE3B SPOCK1 ADAMTSL2	1.46e-05	196	34	4	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 SPRY1 PDE3B RYR2	1.49e-05	197	34	4	6d0d68d460243a0259ada93ebda40fa7b3088eeb
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	UNC13B PDE3B APP ADAMTSL2	1.55e-05	199	34	4	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	UNC13B PDE3B APP ADAMTSL2	1.58e-05	200	34	4	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PDE3B VWF APP ADAMTSL2	1.58e-05	200	34	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PDE3B VWF APP ADAMTSL2	1.58e-05	200	34	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZNF407 VWF MUC2	2.18e-04	154	34	3	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	Ionocyte\|World / shred by cell class for nasal brushing	BNC2 TMEM61 SPOCK1	2.18e-04	154	34	3	6b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B UNC13C ADAMTSL2	2.35e-04	158	34	3	f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B UNC13C ADAMTSL2	2.35e-04	158	34	3	8c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PDE3B ZNF418 RYR2	2.44e-04	160	34	3	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PDE3B ZNF418 RYR2	2.44e-04	160	34	3	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B ERVW-1 OR12D2	2.48e-04	161	34	3	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B ERVW-1 OR12D2	2.48e-04	161	34	3	4f25eeabb841b0b9204cdd4e71d5e131e7868184
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPOCK1 RYR2 ADAMTSL2	2.71e-04	166	34	3	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPOCK1 RYR2 ADAMTSL2	2.71e-04	166	34	3	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UNC13B TMEM61 MUC2	2.81e-04	168	34	3	2163e6774eb7a3d010422e4d59be5e45b4158329
ToppCell	Ionocyte\|World / Class top	COCH APP TMEM61	2.91e-04	170	34	3	d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell	Ionocyte-iono-2\|World / Class top	COCH TMEM61 UNC13A	3.06e-04	173	34	3	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	UNC13C TMEM61 ADAMTSL2	3.06e-04	173	34	3	e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	UNC13C TMEM61 ADAMTSL2	3.06e-04	173	34	3	f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLF18 KNL1 SNX10	3.27e-04	177	34	3	67cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 TMEM61 SPOCK1	3.27e-04	177	34	3	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	VWF APP CCDC116	3.27e-04	177	34	3	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 TMEM61 SPOCK1	3.44e-04	180	34	3	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	368C-Endothelial_cells-Endothelial-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	UNC13C VWF APP	3.44e-04	180	34	3	8ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPRY1 VWF APP	3.44e-04	180	34	3	16728b9a1c52097e3a460534be71a476ecc54f0f
ToppCell	368C-Endothelial_cells-Endothelial-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	UNC13C VWF APP	3.44e-04	180	34	3	394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC116 RYR2 TREML2	3.50e-04	181	34	3	d90faa6115b408c9fbca61fc90ff951e070754ba
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SPRY1 VWF ADAMTSL2	3.55e-04	182	34	3	d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC116 TREML2 KNL1	3.55e-04	182	34	3	11494a66d986297b837332ee9d382b71b9f22591
ToppCell	(4)_B_cells-(4)_B_mantle\|(4)_B_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	SPRY1 ERV3-1 TREML2	3.61e-04	183	34	3	21b7fb6482eb1d5d31a4029e47e0992e8ddc8e2c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPRY1 VWF RYR2	3.61e-04	183	34	3	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALDH8A1 UNC13B VWF	3.61e-04	183	34	3	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 SPRY1 SPOCK1	3.61e-04	183	34	3	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPRY1 VWF RYR2	3.61e-04	183	34	3	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	SPRY1 VWF APP	3.67e-04	184	34	3	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPRY1 VWF APP	3.67e-04	184	34	3	a12a6a481e78adc62da1904431f62b119f70b15f
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D122\|Adult / Lineage, Cell type, age group and donor	BNC2 SPOCK1 ADAMTSL2	3.67e-04	184	34	3	2b7e6f91e11c228f0521e099886867d9e998e78d
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 SPOCK1 ADAMTSL2	3.73e-04	185	34	3	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	UNC13C PDE3B SNX10	3.79e-04	186	34	3	d65fa6d8e8a195ea10cfde1499d096d6acf7a634
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPRY1 COCH SPOCK1	3.79e-04	186	34	3	4e983de6d2515082f9e555f4f949cec84281c140
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B VWF COCH	3.79e-04	186	34	3	ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B VWF COCH	3.79e-04	186	34	3	ed924852cd7132c8f6703522037dc22bd2c83193
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF COCH	3.79e-04	186	34	3	1e67bfb248366d7395efdd2d5e70a97bdb2e68af
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	BNC2 RYR2 ADAMTSL2	3.85e-04	187	34	3	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B VWF COCH	3.85e-04	187	34	3	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	BNC2 PDE3B SPOCK1	3.85e-04	187	34	3	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPRY1 UNC13C ADAMTSL2	3.85e-04	187	34	3	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC13C PDE3B KNL1	3.85e-04	187	34	3	057569c9437219ecc396aa6e673b1178a2273837
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B VWF COCH	3.85e-04	187	34	3	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells-Tumor_ECs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SPRY1 VWF ADAMTSL2	3.85e-04	187	34	3	be5f8c5802b0fa8cc1e274fdf06b13eb8ceb8ad4
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	BNC2 RYR2 ADAMTSL2	3.85e-04	187	34	3	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ZNF407 PDE3B BIRC6	3.91e-04	188	34	3	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COCH TREML2 SNX10	3.91e-04	188	34	3	7b56c680e9f1851cb961b0f8faeeb987685ae36d
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF COCH	3.91e-04	188	34	3	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPRY1 VWF ADAMTSL2	3.91e-04	188	34	3	a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BNC2 SPRY1 SPOCK1	3.91e-04	188	34	3	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	moderate-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BNC2 TMEM61 SPOCK1	3.97e-04	189	34	3	6011b747e27d61d222380a7bffdd921a68e9b657
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	BNC2 SPRY1 UNC13C	3.97e-04	189	34	3	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	BNC2 UNC13C VWF	3.97e-04	189	34	3	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM61 SPOCK1 UNC13A	4.03e-04	190	34	3	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM61 SPOCK1 UNC13A	4.03e-04	190	34	3	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	BNC2 SPRY1 SPOCK1	4.03e-04	190	34	3	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	SPRY1 UNC13C PDE3B	4.03e-04	190	34	3	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC13B VWF COCH	4.03e-04	190	34	3	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPRY1 UNC13C SPOCK1	4.03e-04	190	34	3	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM61 SPOCK1 UNC13A	4.03e-04	190	34	3	a9a705455019e28d655636de73b07540798f82e6
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	BNC2 SPOCK1 RYR2	4.09e-04	191	34	3	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SPRY1 VWF APP	4.09e-04	191	34	3	2f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPRY1 TMEM61 RYR2	4.09e-04	191	34	3	08042952431ca1a6fd7dfc13f36eb28643979598
ToppCell	CV-Severe-5\|Severe / Virus stimulation, Condition and Cluster	PDE3B GPR15 APP	4.09e-04	191	34	3	d04f93fc85c882260ca4d5b4768504fbf8a47984
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	BNC2 UNC13C VWF	4.15e-04	192	34	3	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BNC2 SPRY1 RYR2	4.15e-04	192	34	3	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BNC2 SPRY1 UNC13C	4.15e-04	192	34	3	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPRY1 VWF APP	4.15e-04	192	34	3	c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCell	droplet-Fat-Mat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF RYR2	4.22e-04	193	34	3	54024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	BNC2 SPRY1 SPOCK1	4.22e-04	193	34	3	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	droplet-Fat-Mat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC13B VWF RYR2	4.22e-04	193	34	3	81d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	PDE3B RYR2 ADAMTSL2	4.22e-04	193	34	3	5896242f713ae5fd1a4ebb63827f15d7279dced2
Disease	alcohol use disorder (implicated_via_orthology)	UNC13B UNC13C UNC13A RYR2	5.75e-05	195	32	4	DOID:1574 (implicated_via_orthology)
Disease	Proteinuria	UNC13C VWF	1.19e-04	15	32	2	HP_0000093
Disease	epilepsy (implicated_via_orthology)	UNC13B UNC13C UNC13A	7.30e-04	163	32	3	DOID:1826 (implicated_via_orthology)
Disease	reticulocyte count	ALDH8A1 BNC2 PDE3B VWF BIRC6 TREML2	8.00e-04	1045	32	6	EFO_0007986
Disease	retinal drusen	UNC13C VWF	1.41e-03	51	32	2	EFO_1001155
Disease	generalised epilepsy	SPOCK1 RYR2	1.46e-03	52	32	2	EFO_0005917
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	BNC2 ZNF407 SPOCK1 BIRC6 RYR2	1.60e-03	801	32	5	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	pyroglutamine measurement	BNC2 VWF	1.81e-03	58	32	2	EFO_0005408

Protein segments in the cluster

Peptide	Gene	Start	Entry
QAMTHFACLSSKYMC	UNC13A	876	Q9UPW8
SLHVASCYVCGGMNM	ERV3-1	286	Q14264
SECTQMDHLGCMHYT	ALDH8A1	126	Q9H2A2
SMSNCHSSLMAGCLG	CCDC116	156	Q8IYX3
TCAALLMSPYCGMHS	BIRC6	3361	Q9NR09
YCMAVCGSAMSQSLL	APP	336	P05067
SNGGIMCNICHKMYS	BNC2	1031	Q6ZN30
MCNICHKMYSNKGTL	BNC2	1036	Q6ZN30
SVSGMTMCYACNKSI	ARHGEF2	46	Q92974
CKGSSYMISVNMHCS	GPR15	106	P49685
TMTCMKGTYLVHLTC	CHM	496	P24386
SVCHGSKMSMFRNCF	GRXCR1	251	A8MXD5
YAGCTKTVLMNHCSG	MUC2	5086	Q02817
CNSCGHQMLKYVSTS	PDE3B	576	Q13370
CSATCTTGVMSAYAM	ADAMTSL2	576	Q86TH1
YSSCNDAMEMTKCLS	KNL1	456	Q8NG31
SMLCKALSTCASHFM	OR12D2	231	P58182
SCSYCTMAKKLFHDM	GLRX2	76	Q9NS18
CKMSYSKACHLRTHM	KLF18	971	A0A0U1RQI7
CTHEQMMCSKTCYNS	COCH	351	O43405
MMCSKTCYNSVNIAF	COCH	356	O43405
CELTDSMQCPGTYMH	SPACA4	26	Q8TDM5
KRSNCYMVCAGESMS	RYR2	1481	Q92736
THMPRNCYHSATLCM	ERVW-1	66	Q9UQF0
KRHMASYSMCSDPST	TREML2	291	Q5T2D2
MCDGSHLASTLRYCM	TMEM61	6	Q8N0U2
SYQSHDCSGACLMKM	SETDB2	141	Q96T68
AMTHFSCLSSKYMCP	UNC13C	1421	Q8NB66
HTMCYCEDGFMHCTM	VWF	726	P04275
TEMHCMSGHSNFVSC	PLAA	56	Q9Y263
MVCGSDGHSYTSKCK	SPOCK1	146	Q08629
SHCCSRYLCMGAMSL	SPRY1	251	O43609
AMTHFACLSSKYMCP	UNC13B	801	O14795
IHTNSMCFTMKTSCV	SNX10	36	Q9Y5X0
THYSCGECMKHSSTK	ZNF418	201	Q8TF45
YCGKMCRSSNSMAFL	ZNF407	1541	Q9C0G0