Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	RUVBL1 CCT5 CHD9 ATP11C HFM1 HSPA14 KIF20B SMC1B	5.61e-05	441	61	8	GO:0016887
GeneOntologyMolecularFunction	piRNA binding	PIWIL2 PIWIL3	1.37e-04	6	61	2	GO:0034584
GeneOntologyMolecularFunction	ATP-dependent activity	RUVBL1 CCT5 CHD9 ATP11C HFM1 HSPA14 KIF20B SMC1B	5.35e-04	614	61	8	GO:0140657
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RUVBL1 CCT5 CHD9 ATP11C HFM1 RGS9 HSPA14 KIF20B SMC1B	5.42e-04	775	61	9	GO:0017111
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	ASH1L NSD1	7.01e-04	13	61	2	GO:0046975
GeneOntologyMolecularFunction	pyrophosphatase activity	RUVBL1 CCT5 CHD9 ATP11C HFM1 RGS9 HSPA14 KIF20B SMC1B	9.53e-04	839	61	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RUVBL1 CCT5 CHD9 ATP11C HFM1 RGS9 HSPA14 KIF20B SMC1B	9.62e-04	840	61	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RUVBL1 CCT5 CHD9 ATP11C HFM1 RGS9 HSPA14 KIF20B SMC1B	9.62e-04	840	61	9	GO:0016818
GeneOntologyMolecularFunction	lamin binding	PKP1 DMD	1.52e-03	19	61	2	GO:0005521
GeneOntologyBiologicalProcess	piRNA processing	TDRD7 PIWIL2 PIWIL3	3.64e-05	22	61	3	GO:0034587
GeneOntologyCellularComponent	pole plasm	TDRD7 PIWIL2 PIWIL3	7.79e-05	29	60	3	GO:0045495
GeneOntologyCellularComponent	germ plasm	TDRD7 PIWIL2 PIWIL3	7.79e-05	29	60	3	GO:0060293
GeneOntologyCellularComponent	P granule	TDRD7 PIWIL2 PIWIL3	7.79e-05	29	60	3	GO:0043186
GeneOntologyCellularComponent	R2TP complex	RUVBL1 PIH1D2	8.06e-05	5	60	2	GO:0097255
GeneOntologyCellularComponent	dense body	SND1 PIWIL2	1.69e-04	7	60	2	GO:0097433
GeneOntologyCellularComponent	protein folding chaperone complex	RUVBL1 CCT5 PIH1D2	2.38e-04	42	60	3	GO:0101031
GeneOntologyCellularComponent	chromatoid body	TDRD7 PIWIL2	1.07e-03	17	60	2	GO:0033391
Domain	AWS	ASH1L NSD1	9.75e-05	5	59	2	SM00570
Domain	AWS	ASH1L NSD1	9.75e-05	5	59	2	PS51215
Domain	AWS_dom	ASH1L NSD1	9.75e-05	5	59	2	IPR006560
Domain	PIWI	PIWIL2 PIWIL3	2.71e-04	8	59	2	PS50822
Domain	Piwi	PIWIL2 PIWIL3	2.71e-04	8	59	2	SM00950
Domain	Piwi	PIWIL2 PIWIL3	2.71e-04	8	59	2	IPR003165
Domain	Piwi	PIWIL2 PIWIL3	2.71e-04	8	59	2	PF02171
Domain	PAZ	PIWIL2 PIWIL3	3.48e-04	9	59	2	PS50821
Domain	PAZ	PIWIL2 PIWIL3	3.48e-04	9	59	2	SM00949
Domain	PAZ_dom	PIWIL2 PIWIL3	3.48e-04	9	59	2	IPR003100
Domain	PAZ	PIWIL2 PIWIL3	3.48e-04	9	59	2	PF02170
Domain	TUDOR	TDRD7 SND1	8.71e-04	14	59	2	PF00567
Domain	Post-SET_dom	ASH1L NSD1	1.14e-03	16	59	2	IPR003616
Domain	PostSET	ASH1L NSD1	1.14e-03	16	59	2	SM00508
Domain	POST_SET	ASH1L NSD1	1.14e-03	16	59	2	PS50868
Domain	TUDOR	TDRD7 SND1	2.38e-03	23	59	2	PS50304
Domain	TUDOR	TDRD7 SND1	3.27e-03	27	59	2	SM00333
Domain	Tudor	TDRD7 SND1	4.03e-03	30	59	2	IPR002999
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FASN KRT12 SND1 PYROXD1 CNTRL UBR4 ASH1L ATP11C CAGE1 HEATR1 DMD ZBTB11 SNX9 ERICH6 RPL10 CCDC158	2.44e-09	1442	61	16	35575683
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	FASN ZNF326 RUVBL1 SND1 CCT5 CHD9 SNX9 KIF20B RPL10 CAP1	1.44e-08	494	61	10	26831064
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FASN SND1 CCT5 UBR4 NSD1 HEATR1 ZBTB11 SNX9 RPL10 CAP1	1.94e-07	653	61	10	22586326
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FASN ZNF326 MIS18BP1 RUVBL1 SND1 CCT5 UBR4 PKP1 LTV1 HEATR1 KIF20B CAP1 NMD3	5.09e-07	1353	61	13	29467282
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	FASN RUVBL1 SND1 CCT5 GLG1 CNTRL UBR4 ASH1L RPL10 CAP1	1.33e-06	807	61	10	30575818
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FASN ZNF326 RUVBL1 SND1 CCT5 UBR4 HEATR1 RPL10 CAP1	1.65e-06	638	61	9	33239621
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	FASN SND1 CCT5 UBR4 PKP1 HEATR1 DMD SNX9 RPL10 CAP1	1.98e-06	844	61	10	25963833
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	FASN RUVBL1 SND1 CCT5 UBR4 RPL10	2.55e-06	221	61	6	29991511
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	TDRD7 RUVBL1 SND1 CCT5 ASH1L	2.59e-06	123	61	5	26912792
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	FASN ZNF326 RUVBL1 SND1 CCT5 UBR4 PKP1 LTV1 HEATR1 RPL10 CAP1 NMD3	5.79e-06	1425	61	12	30948266
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ZNF326 RUVBL1 SND1 LTV1 HEATR1 ZBTB11 HSPA14 KIF20B RPL10	6.74e-06	759	61	9	35915203
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FASN ZNF326 RUVBL1 SND1 CCT5 HEATR1 ZBTB11 KIF20B RPL10 NMD3	8.00e-06	989	61	10	36424410
Pubmed	HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma.	RUVBL1 HEATR1	9.07e-06	3	61	2	33894417
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	FASN ZNF326 RUVBL1 SND1 CCT5 PKP1 LTV1 HEATR1 HSPA14 KIF20B RPL10	1.05e-05	1257	61	11	36526897
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FASN RUVBL1 SND1 CCT5 CHD9 DMD PPWD1 KIF20B RPL10	1.12e-05	809	61	9	32129710
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	ODF2L ZNF326 MIS18BP1 RUVBL1 CCT5 CNTRL FAM83G LTV1 SNX9	1.71e-05	853	61	9	28718761
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FASN ZNF326 CBFA2T2 UBR4 PKP1 HEATR1 SNX9 HSPA14 HSD17B8	1.77e-05	857	61	9	25609649
Pubmed	Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.	PIWIL2 PIWIL3	1.81e-05	4	61	2	28025795
Pubmed	Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population.	PIWIL2 PIWIL3	1.81e-05	4	61	2	20940137
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	FASN RUVBL1 SND1 CCT5 LTV1 RPL10	2.50e-05	330	61	6	32529326
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	FASN RUVBL1 SND1 CCT5 UBR4 RPL10	2.58e-05	332	61	6	32786267
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	ASH1L NSD1	3.02e-05	5	61	2	39390582
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FASN ZNF326 RUVBL1 SND1 UBR4 HEATR1 HSPA14 RPL10	3.10e-05	704	61	8	29955894
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	FASN RUVBL1 SND1 CCT5 GLG1 UBR4 PKP1 LTV1 PPWD1 HSPA14 RPL10	3.13e-05	1415	61	11	28515276
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	SHLD2 RUVBL1 CCT5 PKP1 LTV1 HSPA14	3.25e-05	346	61	6	25324306
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	RUVBL1 ASH1L NSD1 CHD9 HEATR1 ZBTB11 SNX9	4.07e-05	533	61	7	30554943
Pubmed	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.	FASN SND1 CCT5 CAP1	4.30e-05	110	61	4	18307411
Pubmed	La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).	RUVBL1 CCT5 SNX9 CAP1	4.30e-05	110	61	4	25940091
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	ZNF326 RUVBL1 CCT5 DMD PPWD1 RPL10 CAP1	4.32e-05	538	61	7	28524877
Pubmed	Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.	ASH1L NSD1	4.52e-05	6	61	2	24019522
Pubmed	The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.	RUVBL1 PIH1D2	4.52e-05	6	61	2	29844425
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FASN RUVBL1 SND1 CCT5 NSD1 HEATR1 SNX9	4.91e-05	549	61	7	38280479
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FASN ZNF326 RUVBL1 SND1 CCT5 UBR4 PKP1	5.02e-05	551	61	7	34728620
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	FASN GLG1 ARHGEF9 DMD ADGRG4 RPL10	5.63e-05	382	61	6	37249651
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FASN ZNF326 RUVBL1 SND1 CCT5 PKP1 HEATR1 SNX9 RPL10	7.05e-05	1024	61	9	24711643
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	RUVBL1 PKP1 CAGE1 SNX9	7.76e-05	128	61	4	23858473
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FASN ZNF326 RUVBL1 SND1 CCT5 UBR4 LTV1 HEATR1 RPL10 NMD3	9.16e-05	1318	61	10	30463901
Pubmed	Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model.	FASN RUVBL1 CCT5 RPL10	9.54e-05	135	61	4	31405213
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	FASN ZNF326 RUVBL1 SND1 CCT5 LTV1 SNX9 HSPA14 RPL10 NMD3	1.02e-04	1335	61	10	29229926
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	FASN KRT12 RUVBL1 CCT5 UBR4	1.06e-04	266	61	5	19380743
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	FASN ZNF326 RUVBL1 CCT5 HEATR1 RPL10	1.08e-04	430	61	6	38172120
Pubmed	Identification of eight members of the Argonaute family in the human genome.	PIWIL2 PIWIL3	1.08e-04	9	61	2	12906857
Pubmed	Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.	FASN ZNF326 RUVBL1 PKP1 LTV1 HEATR1 RPL10	1.29e-04	641	61	7	36057605
Pubmed	Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.	TDRD7 PIWIL2	1.35e-04	10	61	2	19584108
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	ZNF326 CCT5 UBR4 HEATR1 NMD3	1.53e-04	288	61	5	23383273
Pubmed	Next-generation sequencing to generate interactome datasets.	TDRD7 PYROXD1 CGRRF1 CBFA2T2 PIH1D2 DMRTB1 TRIM39 CAGE1 NMD3	1.66e-04	1147	61	9	21516116
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	FASN ZNF326 SND1 CCT5 PIWIL3 RPL10	1.89e-04	477	61	6	31300519
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	ZNF326 SND1 CCT5 HEATR1	1.92e-04	162	61	4	31363146
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FASN SND1 UBR4 LTV1 HEATR1 SNX9 HSPA14 NMD3	2.33e-04	942	61	8	31073040
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	FASN SND1 CCT5 UBR4 HEATR1 RPL10 CAP1	2.34e-04	707	61	7	19738201
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	FASN RUVBL1 SND1 CCT5 LTV1 SNX9 CAP1	2.36e-04	708	61	7	39231216
Pubmed	HIV-host interactome revealed directly from infected cells.	FASN RUVBL1 CCT5 GLG1	2.42e-04	172	61	4	27375898
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	FASN RUVBL1 CCT5 GLG1 UBR4 HEATR1 RPL10	2.43e-04	711	61	7	33022573
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF326 SND1 CCT5 GLG1 ARHGEF9 NSD1 HEATR1 ZBTB11 KIF20B RPL10	2.58e-04	1497	61	10	31527615
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	FASN RUVBL1 CCT5 RPL10	2.58e-04	175	61	4	25756610
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	FASN RUVBL1 CCT5 KIF20B RPL10 CAP1	2.60e-04	506	61	6	30890647
Pubmed	Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.	RUVBL1 SND1 CCT5 RPL10 CAP1	2.75e-04	327	61	5	34428256
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	FASN RUVBL1 SND1 CCT5 GLG1 LTV1 ZBTB11 RPL10	2.85e-04	971	61	8	33306668
Pubmed	BGL3 lncRNA mediates retention of the BRCA1/BARD1 complex at DNA damage sites.	FASN SND1 CCT5	2.93e-04	73	61	3	32347575
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	MIS18BP1 HSD17B8 RPL10	3.05e-04	74	61	3	29795351
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FASN ZNF326 RUVBL1 CCT5 CNTRL HEATR1 DMD	3.46e-04	754	61	7	35906200
Pubmed	Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?	TDRD7 PIWIL2	3.57e-04	16	61	2	16787967
Pubmed	Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression.	PIWIL2 SMC1B	4.05e-04	17	61	2	19345099
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	FASN KRT12 SND1 CCT5 PKP1 RPL10	4.37e-04	558	61	6	27591049
Pubmed	CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.	SND1 LTV1 HSPA14 RPL10	4.37e-04	201	61	4	34917906
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR4 ARNT2 CHD9	4.90e-04	87	61	3	12465718
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	FASN SND1 GLG1 ARNT2	5.53e-04	214	61	4	22199357
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	ZNF326 RUVBL1 SND1 RPL10	6.13e-04	220	61	4	34091597
Pubmed	Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.	RUVBL1 CCT5	6.22e-04	21	61	2	25467444
Pubmed	SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.	RUVBL1 SND1 CCT5	6.33e-04	95	61	3	33863777
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	RUVBL1 SND1 CCT5	6.73e-04	97	61	3	37151849
Pubmed	The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.	KRT12 PKP1 CAP1	7.35e-04	100	61	3	21800051
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	ZNF326 KRT12	8.15e-04	24	61	2	27507811
Pubmed	β-dystroglycan is regulated by a balance between WWP1-mediated degradation and protection from WWP1 by dystrophin and utrophin.	SND1 RPL10	8.15e-04	24	61	2	29635000
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	FASN RUVBL1 SND1 CCT5 UBR4 SNX9 RPL10 CAP1	8.64e-04	1149	61	8	35446349
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	RUVBL1 CCT5 UBR4 PKP1 ADGRG4 RPL10	8.86e-04	639	61	6	23443559
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	FASN RUVBL1 CCT5 RPL10	9.01e-04	244	61	4	28902428
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	NSD1 CHD9 KIF20B	9.44e-04	109	61	3	33554859
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	FASN RUVBL1 CCT5 UBR4 RPL10 CAP1	9.44e-04	647	61	6	26618866
Pubmed	Defining the membrane proteome of NK cells.	FASN GLG1 CNTRL UBR4 HEATR1 HSPA14 RPL10 NMD3	9.60e-04	1168	61	8	19946888
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZNF326 GLG1 LTV1 RPL10	1.00e-03	251	61	4	28077445
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	FASN CCT5	1.03e-03	27	61	2	36266428
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	ZNF326 KRT12 RUVBL1 SND1 HEATR1 PPWD1	1.05e-03	660	61	6	32780723
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	FASN RUVBL1 CCT5 RPL10	1.08e-03	256	61	4	35777956
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FASN RUVBL1 SND1 HEATR1	1.08e-03	256	61	4	33397691
Pubmed	Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.	FASN RUVBL1 CCT5 RPL10	1.08e-03	256	61	4	32698014
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	LTV1 KIF20B CCDC158	1.13e-03	116	61	3	21282530
Pubmed	Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.	FASN RUVBL1 CCT5 SNX9 RPL10	1.15e-03	449	61	5	31732153
Pubmed	Deep sequencing and proteomic analysis of the microRNA-induced silencing complex in human red blood cells.	UBR4 SNX9	1.19e-03	29	61	2	25681748
Pubmed	TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.	TDRD7 PIWIL2	1.19e-03	29	61	2	21383078
Pubmed	A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma.	HFM1 HSPA14	1.19e-03	29	61	2	28604741
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	CCT5 LTV1 HEATR1 PPWD1 CAP1	1.21e-03	454	61	5	33226137
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FASN RUVBL1 SND1 LTV1 HEATR1 SNX9 RPL10	1.22e-03	934	61	7	33916271
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	FASN RUVBL1 HEATR1	1.25e-03	120	61	3	27320910
Pubmed	SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.	RUVBL1 CCT5 RPL10	1.25e-03	120	61	3	37929963
Pubmed	Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.	TPO KIF20B	1.28e-03	30	61	2	24554482
Pubmed	VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma.	SND1 CCT5 RPL10	1.31e-03	122	61	3	36929488
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	ODF2L FASN MIS18BP1 RUVBL1 RPL10	1.32e-03	463	61	5	27503909
Pubmed	Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.	FASN CCT5 RPL10 CAP1	1.33e-03	271	61	4	26816005
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	FASN RUVBL1 UBR4 SNX9	1.35e-03	272	61	4	31010829
Cytoband	1p22.2	ZNF326 HFM1	6.42e-04	28	61	2	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	ODF2L ZNF326 HFM1	8.24e-04	137	61	3	chr1p22
GeneFamily	Argonaute/PIWI family	PIWIL2 PIWIL3	1.61e-04	8	44	2	408
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	ODF2L FASN ZNF326 MIS18BP1 PYROXD1 CNTRL NSD1 PKP1 CHD9 ATP11C HEATR1 DMD PPWD1 KIF20B NMD3	9.43e-07	1257	58	15	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000	MIS18BP1 RUVBL1 CBFA2T2 LTV1 PIWIL2 HEATR1 HSPA14 KIF20B NMD3	4.26e-06	463	58	9	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500	ODF2L FASN ZNF326 MIS18BP1 PYROXD1 CNTRL NSD1 PKP1 CHD9 ATP11C HEATR1 DMD PPWD1 KIF20B NMD3	5.96e-06	1459	58	15	facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	MIS18BP1 CBFA2T2 HFM1 LTV1 PIWIL2 HEATR1 HSPA14 KIF20B SMC1B NMD3 IQCG	8.62e-06	795	58	11	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	ODF2L FASN ZNF326 MIS18BP1 CBFA2T2 CNTRL ARNT2 CHD9 ATP11C HEATR1 DMD KIF20B	2.38e-05	1060	58	12	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_top-relative-expression-ranked_1000	MIS18BP1 RUVBL1 CBFA2T2 LTV1 PIWIL2 HEATR1 HSPA14 KIF20B SMC1B NMD3	4.51e-05	781	58	10	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e11.5_F_PrimGermCell_Oct_top-relative-expression-ranked_1000	MIS18BP1 RUVBL1 CBFA2T2 LTV1 PIWIL2 HEATR1 HSPA14 KIF20B SMC1B NMD3	5.46e-05	799	58	10	gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	TDRD7 MIS18BP1 RUVBL1 HFM1 LTV1 PIWIL2 HEATR1 KIF20B SMC1B IQCG	6.12e-05	810	58	10	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	MIS18BP1 HFM1 PIWIL2 HEATR1 KIF20B SMC1B IQCG	8.55e-05	387	58	7	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	TDRD7 MIS18BP1 ATP11C HFM1 LTV1 PIWIL2 HEATR1 SMC1B NMD3	3.56e-04	820	58	9	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	MIS18BP1 CBFA2T2 HFM1 LTV1 PIWIL2 HEATR1 KIF20B SMC1B NMD3	3.63e-04	822	58	9	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500	ODF2L FASN ZNF326 MIS18BP1 CBFA2T2 CNTRL ARNT2 CHD9 ATP11C HEATR1 DMD KIF20B	3.69e-04	1414	58	12	facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_top-relative-expression-ranked_500	MIS18BP1 CBFA2T2 PIWIL2 HEATR1 KIF20B SMC1B	5.52e-04	376	58	6	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_200	HFM1 PIWIL2 SMC1B IQCG	5.67e-04	139	58	4	gudmap_dev gonad_e13.5_M_GermCell_Oct_200
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_500	MIS18BP1 PIWIL2 HEATR1 KIF20B	6.15e-04	142	58	4	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k3_500
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_500	TDRD7 MIS18BP1 HFM1 LTV1 PIWIL2 SMC1B	6.24e-04	385	58	6	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_500
CoexpressionAtlas	dev gonad_e11.5_M_PrimGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000	MIS18BP1 LTV1 PIWIL2 KIF20B NMD3	6.90e-04	258	58	5	gudmap_dev gonad_e11.5_M_PrimGermCell_Oct_k2_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_500	MIS18BP1 HFM1 PIWIL2 HEATR1 SMC1B IQCG	7.23e-04	396	58	6	gudmap_dev gonad_e13.5_M_GermCell_Oct_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_500	MIS18BP1 HFM1 LTV1 PIWIL2 HEATR1 SMC1B	8.23e-04	406	58	6	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_500
Disease	alpha fetoprotein measurement	SHLD2 CHD9 SMC1B	1.07e-03	100	59	3	EFO_0010583
Disease	autism spectrum disorder (implicated_via_orthology)	ASH1L PKP1 CHD9	3.53e-03	152	59	3	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GIKQDIMKTIRNIIN	ERICH6	646	Q7L0X2
TKRNNGQLMKTIIRK	ASH1L	971	Q9NR48
MSKQAEVLIKGKRQT	CNTRL	2256	Q7Z7A1
RVKELQMKITKQQVF	CAGE1	336	Q8TC20
NSVKSQIQKTRRKMI	ADGRG4	2921	Q8IZF6
VLIAIMVKVNFQRKK	ADAM2	701	Q99965
IINSKDVKVQVMGKV	CAP1	391	Q01518
MVIKTGRQIVQKKQT	DMD	1521	P11532
QKRQAAMTVRKVPKQ	ARHGEF9	441	O43307
FQQVVKLKGQVLSVM	ARNT2	386	Q9HBZ2
RQTIMTTETLKKIQI	IQCG	156	Q9H095
AQMVKNTVNRKALKT	NSD1	1036	Q96L73
NQITKTKNKNVEKMR	ODF2L	441	Q9ULJ1
VNQKQTVVAVKKEIM	RGS9	216	O75916
QVIVSFIKMLKRNVK	OR5H15	296	A6NDH6
ITAKVGTLKRKQQMR	MIS18BP1	961	Q6P0N0
KKGLTAKQTERIQMI	LTV1	391	Q96GA3
KTRKIKTVVQEMVNG	KRT12	466	Q99456
NKVKIQAMSEVQKAV	CBFA2T2	446	O43439
TSIQAMKRKVNLKTQ	TPO	96	P07202
KKQIKQVQKEVSVMR	KIF20B	1296	Q96Q89
VKIVQTEMNKGKSRN	HFM1	191	A2PYH4
PVKRLKIQMNKSQSV	HFM1	1191	A2PYH4
KCKQMITKRQITQNT	GLG1	916	Q92896
QNTQVRVMSEKKQRK	CHD9	501	Q3L8U1
RQKIMAAQKVLKTQA	DMRTB1	46	Q96MA1
MTQKVPQKVVDKITE	HSD17B8	206	Q92506
TVQQKRRQKMQQKKS	HEATR1	1176	Q9H583
SSMIRNQEKRIQKVK	CCDC158	1091	Q5M9N0
QALQTKVTQQGLKMV	FASN	1146	P49327
QFSTRVFKKQMRQVK	CGRRF1	51	Q99675
KVQARTIVTKIAQQM	PIWIL3	616	Q7Z3Z3
NIQKMQKTQVKCRKI	CCDC159	176	P0C7I6
RIRNISNTVMKVKQI	HSPA14	56	Q0VDF9
VVKEKITKVTTQQIM	MUC17	4271	Q685J3
IKEVVRKMISQAQKV	FAM83G	161	A6ND36
VQEQVMMTVKRQKSK	PKP1	41	Q13835
TSKITLQDKQNMVKR	SNX9	526	Q9Y5X1
SMVEIAKQLQAVKRK	TRIM39	86	Q9HCM9
KKKVAQMVEARIQTQ	TMC3	726	Q7Z5M5
KQMINRNKVVKVTAP	SLC24A2	291	Q9UI40
IGQVIMSIRTKLQNK	RPL10	131	P27635
MQVEVEKQNRKKSPV	SCHIP1	381	P0DPB3
KMVVFVVQKKISTNL	PIWIL2	846	Q8TC59
MEVVQRISNVKVNPK	PPWD1	616	Q96BP3
RGQKQKKVMLTVEQA	SHLD2	616	Q86V20
VMVEVRKEKQFQKVI	SND1	861	Q7KZF4
IGKKQQISLATQMVR	CCT5	511	P48643
KTGRQVNCQMRVKKT	TDRD7	96	Q8NHU6
QQKLKQRITVLETKM	CNGA2	626	Q16280
LNRKIVQVMRKQKTI	CLCN2	341	P51788
LQKAQIVRMVKNLKG	ATP11C	796	Q8NB49
TKFRIKGSIQRMKQN	PIH1D2	151	Q8WWB5
QVAQKLVQRGKKMKQ	ZBTB11	541	O95625
EVQQMLQVSKKRLIS	THAP9	141	Q9H5L6
QKQLTKAKRIMIIGN	PYROXD1	141	Q8WU10
QVRKKVATMTQQLEK	SMC1B	381	Q8NDV3
MKQIIKIRAQTEGIN	RUVBL1	371	Q9Y265
KIIQRTKKMVNKIVQ	PLAAT5	211	Q96KN8
VKVKVNRQQLVKLEM	UBR4	4516	Q5T4S7
MVNKFKKTSIRKQQT	ZNF326	361	Q5BKZ1
KVKLTIQKEVMNGAI	NMD3	111	Q96D46