Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	2.10e-05	2	92	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	2.10e-05	2	92	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	2.10e-05	2	92	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	2.10e-05	2	92	2	GO:0004354
GeneOntologyMolecularFunction	Notch binding	DTX1 ATRNL1 EGFL7	2.56e-04	27	92	3	GO:0005112
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF274 ZNF473 NFATC1 ZNF587 ZNF180 ZNF722 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 NFAT5 ZNF865 ZNF441 ZNF669 ZNF44	3.25e-04	1459	92	17	GO:0000977
GeneOntologyMolecularFunction	NAD binding	PARP1 GLUD1 GLUD2 ME2	3.60e-04	73	92	4	GO:0051287
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	4.34e-04	7	92	2	GO:0070728
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF274 ZNF473 NFATC1 ZNF587 ZNF180 ZNF722 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 NFAT5 ZNF441 ZNF669 ZNF44	6.76e-04	1412	92	16	GO:0000981
Domain	-	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	4.95e-06	679	91	14	3.30.160.60
Domain	zf-C2H2	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	6.25e-06	693	91	14	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	6.35e-06	694	91	14	IPR013087
Domain	Kelch-typ_b-propeller	KLHDC1 KLHL30 ATRNL1 KBTBD8 CCIN	7.05e-06	55	91	5	IPR015915
Domain	KRAB	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 ZNF417 ZNF471 ZNF441 ZNF669 ZNF44	9.57e-06	358	91	10	PS50805
Domain	KRAB	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 ZNF417 ZNF471 ZNF441 ZNF669 ZNF44	9.57e-06	358	91	10	PF01352
Domain	KRAB	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 ZNF417 ZNF471 ZNF441 ZNF669 ZNF44	1.24e-05	369	91	10	SM00349
Domain	KRAB	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 ZNF417 ZNF471 ZNF441 ZNF669 ZNF44	1.27e-05	370	91	10	IPR001909
Domain	ZINC_FINGER_C2H2_2	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	2.19e-05	775	91	14	PS50157
Domain	zf-C2H2_6	ZNF473 ZNF587 ZNF735 MECOM ZNF841 ZNF417 ZNF865 ZNF669 ZNF44	2.24e-05	314	91	9	PF13912
Domain	ZINC_FINGER_C2H2_1	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	2.26e-05	777	91	14	PS00028
Domain	Kelch_1	KLHDC1 KLHL30 ATRNL1 KBTBD8 CCIN	2.32e-05	70	91	5	PF01344
Domain	Kelch_1	KLHDC1 KLHL30 ATRNL1 KBTBD8 CCIN	2.32e-05	70	91	5	IPR006652
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	2.35e-05	2	91	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	2.35e-05	2	91	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	2.35e-05	2	91	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	2.35e-05	2	91	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	2.35e-05	2	91	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	2.35e-05	2	91	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	2.35e-05	2	91	2	IPR033524
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	2.35e-05	2	91	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	2.35e-05	2	91	2	PS00074
Domain	Znf_C2H2-like	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	2.95e-05	796	91	14	IPR015880
Domain	Znf_C2H2	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	3.33e-05	805	91	14	IPR007087
Domain	ZnF_C2H2	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	3.47e-05	808	91	14	SM00355
Domain	-	KLHDC1 KLHL30 ATRNL1 KBTBD8	8.71e-05	48	91	4	2.120.10.80
Domain	Cupredoxin	EFNA5 PKHD1L1 PADI3	1.61e-04	22	91	3	IPR008972
Domain	NFAT	NFATC1 NFAT5	2.33e-04	5	91	2	IPR008366
Domain	IPT	NFATC1 NFAT5 PKHD1L1	3.01e-04	27	91	3	SM00429
Domain	TIG	NFATC1 NFAT5 PKHD1L1	4.56e-04	31	91	3	PF01833
Domain	IPT	NFATC1 NFAT5 PKHD1L1	5.01e-04	32	91	3	IPR002909
Domain	Biotin_lipoyl	MCCC1 DBT	8.27e-04	9	91	2	PF00364
Domain	RHD_dimer	NFATC1 NFAT5	1.03e-03	10	91	2	IPR032397
Domain	RHD_dimer	NFATC1 NFAT5	1.03e-03	10	91	2	PF16179
Domain	NFkB/Dor	NFATC1 NFAT5	1.03e-03	10	91	2	IPR000451
Domain	REL_1	NFATC1 NFAT5	1.03e-03	10	91	2	PS01204
Domain	RHD_DNA_bind_dom	NFATC1 NFAT5	1.03e-03	10	91	2	IPR011539
Domain	RHD_DNA_bind	NFATC1 NFAT5	1.03e-03	10	91	2	PF00554
Domain	REL_2	NFATC1 NFAT5	1.03e-03	10	91	2	PS50254
Domain	Biotin_lipoyl	MCCC1 DBT	1.03e-03	10	91	2	IPR000089
Domain	BIOTINYL_LIPOYL	MCCC1 DBT	1.03e-03	10	91	2	PS50968
Domain	-	NFATC1 NFAT5	1.03e-03	10	91	2	2.60.40.340
Domain	Single_hybrid_motif	MCCC1 DBT	1.50e-03	12	91	2	IPR011053
Domain	Kelch_2	KLHDC1 ATRNL1	1.77e-03	13	91	2	IPR011498
Domain	Kelch_2	KLHDC1 ATRNL1	1.77e-03	13	91	2	PF07646
Domain	Integrin_alpha_C_CS	ITGA1 ITGA3	2.70e-03	16	91	2	IPR018184
Domain	Kelch	KLHL30 KBTBD8 CCIN	2.84e-03	58	91	3	SM00612
Domain	Retrov_capsid_C	ZNF274 ERVK-5 ZSCAN16	2.99e-03	59	91	3	IPR008916
Domain	Gal_Oxase/kelch_b-propeller	KLHDC1 KBTBD8 CCIN	2.99e-03	59	91	3	IPR011043
Domain	BACK	KLHL30 KBTBD8 CCIN	3.13e-03	60	91	3	SM00875
Domain	BACK	KLHL30 KBTBD8 CCIN	3.28e-03	61	91	3	PF07707
Domain	BACK	KLHL30 KBTBD8 CCIN	3.28e-03	61	91	3	IPR011705
Domain	Integrin_alpha-2	ITGA1 ITGA3	3.41e-03	18	91	2	IPR013649
Domain	Integrin_alpha2	ITGA1 ITGA3	3.41e-03	18	91	2	PF08441
Domain	Integrin_alpha	ITGA1 ITGA3	3.41e-03	18	91	2	IPR000413
Domain	INTEGRIN_ALPHA	ITGA1 ITGA3	3.41e-03	18	91	2	PS00242
Domain	Int_alpha_beta-p	ITGA1 ITGA3	3.80e-03	19	91	2	IPR013519
Domain	Int_alpha	ITGA1 ITGA3	3.80e-03	19	91	2	SM00191
Domain	FG_GAP	ITGA1 ITGA3	5.09e-03	22	91	2	PS51470
Domain	FG-GAP	ITGA1 ITGA3	6.04e-03	24	91	2	PF01839
Domain	FG-GAP	ITGA1 ITGA3	6.04e-03	24	91	2	IPR013517
Domain	Integrin_dom	ITGA1 ITGA3	6.55e-03	25	91	2	IPR032695
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF274 ZNF587 ZNF841 ZNF417 ZNF441 ZNF669 ZNF44	5.55e-07	181	92	7	37372979
Pubmed	Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice.	PARP1 GLUD1 GLUD2	1.49e-06	9	92	3	9756038
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	6.92e-06	2	92	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	6.92e-06	2	92	2	28621566
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	6.92e-06	2	92	2	32078638
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	6.92e-06	2	92	2	23595828
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	6.92e-06	2	92	2	21621574
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	6.92e-06	2	92	2	28911206
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	6.92e-06	2	92	2	22875990
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	6.92e-06	2	92	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	6.92e-06	2	92	2	15044002
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	6.92e-06	2	92	2	22138648
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	6.92e-06	2	92	2	34220417
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	6.92e-06	2	92	2	26241911
Pubmed	Changes in integrin expression during chondrogenesis in vitro: an immunomorphological study.	ITGA1 ITGA3	6.92e-06	2	92	2	7560884
Pubmed	The role of NFAT transcription factors in integrin-mediated carcinoma invasion.	NFATC1 NFAT5	6.92e-06	2	92	2	12080349
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	6.92e-06	2	92	2	21446915
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	6.92e-06	2	92	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	6.92e-06	2	92	2	24593767
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	6.92e-06	2	92	2	37154294
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	6.92e-06	2	92	2	22924626
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	6.92e-06	2	92	2	11032875
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	6.92e-06	2	92	2	29943084
Pubmed	NFAT5 regulates transcription of the mouse telomerase reverse transcriptase gene.	NFAT5 TERT	6.92e-06	2	92	2	20937271
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	6.92e-06	2	92	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	6.92e-06	2	92	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	6.92e-06	2	92	2	27422263
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	6.92e-06	2	92	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	6.92e-06	2	92	2	1711373
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	6.92e-06	2	92	2	20529287
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	6.92e-06	2	92	2	25124006
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	6.92e-06	2	92	2	23673664
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	6.92e-06	2	92	2	39052831
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	6.92e-06	2	92	2	24442550
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	6.92e-06	2	92	2	27137930
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	6.92e-06	2	92	2	26440896
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	6.92e-06	2	92	2	12742085
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	6.92e-06	2	92	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	6.92e-06	2	92	2	22658952
Pubmed	PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation.	PARP1 NFATC1	6.92e-06	2	92	2	31793068
Pubmed	PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage.	PARP1 NFAT5	6.92e-06	2	92	2	34049076
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	6.92e-06	2	92	2	38124277
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	6.92e-06	2	92	2	19015267
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	6.92e-06	2	92	2	19448744
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	6.92e-06	2	92	2	11950837
Pubmed	[Effect of osmotic response element binding protein on mucus secretion with hypertonicity in human airway epithelial cells].	NFAT5 MUC5AC	2.07e-05	3	92	2	21418859
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	2.07e-05	3	92	2	12054821
Pubmed	Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese.	TH GRK4	2.07e-05	3	92	2	16636198
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	2.07e-05	3	92	2	31704028
Pubmed	The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage.	IL25 IL2RA	2.07e-05	3	92	2	22266274
Pubmed	Expression of beta 1 integrins in human dental pulp in vivo: a comparative immunohistochemical study on healthy and chronic marginal periodontitis samples.	ITGA1 ITGA3	2.07e-05	3	92	2	11307375
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	2.07e-05	3	92	2	29784783
Pubmed	Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.	GLUD1 GLUD2	2.07e-05	3	92	2	29229616
Pubmed	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.	GLUD1 GLUD2	2.07e-05	3	92	2	30002133
Pubmed	Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	GLUD1 GLUD2	2.07e-05	3	92	2	30315226
Pubmed	Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1.	PARP1 NFAT5	2.07e-05	3	92	2	17148781
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	2.07e-05	3	92	2	3585334
Pubmed	GOT1 regulates CD8+ effector and memory T cell generation.	GLUD1 GLUD2	2.07e-05	3	92	2	36640309
Pubmed	Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.	GLUD1 GLUD2	2.07e-05	3	92	2	37871770
Pubmed	Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.	PARP1 NFATC1	2.07e-05	3	92	2	18078995
Pubmed	Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.	GLUD1 GLUD2	2.07e-05	3	92	2	23560106
Pubmed	Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.	GLUD1 GLUD2	2.07e-05	3	92	2	20670938
Pubmed	Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.	GLUD1 GLUD2	2.07e-05	3	92	2	24295216
Pubmed	Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.	GLUD1 GLUD2	4.14e-05	4	92	2	24872547
Pubmed	Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.	GLUD1 GLUD2	4.14e-05	4	92	2	25721396
Pubmed	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.	GLUD1 GLUD2	4.14e-05	4	92	2	23663782
Pubmed	GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.	GLUD1 GLUD2	4.14e-05	4	92	2	39121856
Pubmed	A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.	GLUD1 GLUD2	4.14e-05	4	92	2	2566156
Pubmed	Effect of exercise on telomere length and telomere proteins expression in mdx mice.	PARP1 TERT	4.14e-05	4	92	2	32447718
Pubmed	Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.	ITGA1 ITGA3	4.14e-05	4	92	2	8626034
Pubmed	Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.	ITGA1 ITGA3	4.14e-05	4	92	2	23236390
Pubmed	Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.	UNC13D MUC5AC	4.14e-05	4	92	2	29767240
Pubmed	The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.	ITGA1 ITGA3	4.14e-05	4	92	2	3033641
Pubmed	Inherited genetic variants associated with occurrence of multiple primary melanoma.	PARP1 TERT	4.14e-05	4	92	2	25837821
Pubmed	Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.	GLUD1 GLUD2	6.89e-05	5	92	2	3182016
Pubmed	SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.	GLUD1 GLUD2	6.89e-05	5	92	2	16959573
Pubmed	Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit.	ITGA1 ITGA3	6.89e-05	5	92	2	7681433
Pubmed	Genomic organization and chromosomal localization of the mouse synexin gene.	GLUD1 GLUD2	6.89e-05	5	92	2	8053909
Pubmed	Macrophage-derived glutamine boosts satellite cells and muscle regeneration.	GLUD1 GLUD2	6.89e-05	5	92	2	33116312
Pubmed	Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway.	TH EFNA5	6.89e-05	5	92	2	19576892
Pubmed	Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14.	GLUD1 GLUD2	6.89e-05	5	92	2	2045113
Pubmed	Mutation of FAS, XIAP, and UNC13D genes in a patient with a complex lymphoproliferative phenotype.	XIAP UNC13D	6.89e-05	5	92	2	24043286
Pubmed	Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.	GLUD1 GLUD2	6.89e-05	5	92	2	7873882
Pubmed	Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin.	ITGA1 ITGA3	6.89e-05	5	92	2	10684262
Pubmed	NFAT: ubiquitous regulator of cell differentiation and adaptation.	NFATC1 NFAT5	6.89e-05	5	92	2	11877454
Pubmed	IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.	PARP1 XIAP	6.89e-05	5	92	2	15580265
Pubmed	Primary Ciliary Dyskinesia	DNAAF5 RSPH4A DNAH11	8.40e-05	32	92	3	20301301
Pubmed	A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.	NFATC1 NFAT5	1.03e-04	6	92	2	16141075
Pubmed	The human glutamate dehydrogenase gene family: gene organization and structural characterization.	GLUD1 GLUD2	1.03e-04	6	92	2	8486350
Pubmed	Screening the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK gene mutations in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.	XIAP UNC13D	1.03e-04	6	92	2	21674762
Pubmed	The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.	ITGA1 ITGA3	1.03e-04	6	92	2	1690718
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	RSPH4A DNAH11	1.03e-04	6	92	2	33347437
Pubmed	Computer sequence analysis of human highly conserved zinc finger modules.	ZNF274 ZNF587	1.03e-04	6	92	2	10520746
Pubmed	Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants.	TH SYP	1.03e-04	6	92	2	17543467
Pubmed	The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins.	NFATC1 NFAT5	1.03e-04	6	92	2	25728138
Pubmed	The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.	ITGA1 ITGA3	1.03e-04	6	92	2	3546305
Pubmed	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.	KBTBD8 MECOM WDR72	1.30e-04	37	92	3	22797727
Pubmed	Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.	GLUD1 GLUD2	1.44e-04	7	92	2	10454512
Pubmed	A temporal and spatial map of axons in developing mouse prostate.	TH SYP	1.44e-04	7	92	2	30976911
Pubmed	RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.	GLUD1 GLUD2	1.44e-04	7	92	2	19498109
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF274 ZNF473 ZNF587 ZNF180 ZNF735 MECOM ZNF841 ZSCAN16 ZNF417 ZNF471 ZNF865 ZNF441 ZNF669 ZNF44	2.44e-07	718	66	14	28
GeneFamily	Nuclear factors of activated T-cells	NFATC1 NFAT5	1.30e-04	5	66	2	665
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA1 ITGA3	1.93e-03	18	66	2	1160
Coexpression	OISHI_CHOLANGIOMA_STEM_CELL_LIKE_UP	PARP1 ZNF473 ZNF587 FGF1 MRPS16 ZSCAN16 MCCC1 PPM1B ZNF669	2.96e-06	349	89	9	M283
Coexpression	GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_3H_UP	B4GALT2 A1BG FCRL2 DTX1 ZNF587 GZMK DENND5A	4.07e-06	191	89	7	M8251
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL2 AMPD3 ZNF473 NFATC1 HLA-DOB CCDC85A DNAH11	8.24e-08	178	91	7	812e261d9cbdc74fafe3c5c3422151c1cfacb22d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 CECR2 MECOM RP1 ITGA3 HECTD1 ZNF44	9.60e-08	182	91	7	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Lymphatic\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	EFNA5 NFATC1 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	1.76e-07	199	91	7	88f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EFNA5 NFATC1 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	1.76e-07	199	91	7	64b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EFNA5 NFATC1 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	1.76e-07	199	91	7	2b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Th_Sst\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TH DHX58 PJVK LTBP1 CAPS2	2.27e-07	65	91	5	c336aa3501b9576bf12ef1bbefae55fff7705662
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSNAXIP1 RSPH4A RP1 CFAP61 CAPS2 DNAH11	7.94e-07	155	91	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSNAXIP1 RSPH4A RP1 CFAP61 CAPS2 DNAH11	7.94e-07	155	91	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFATC1 HLA-DOB KBTBD8 UNC13D TERT WDR72	9.56e-07	160	91	6	cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFATC1 DTX1 PCSK6 EGFL7 NFAT5 PKHD1L1	1.03e-06	162	91	6	96c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D122\|Adult / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	1.51e-06	173	91	6	dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	1.78e-06	178	91	6	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	COVID-19-Neuronal_cells-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	2.22e-06	185	91	6	4a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell	COVID-19-Neuronal_cells\|COVID-19 / group, cell type (main and fine annotations)	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	2.22e-06	185	91	6	36ce23893915f5c380cca39b2c33a516edf31c3a
ToppCell	BL-critical-LOC-Lymphoid-B_cell\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FCRL2 PARP1 HLA-DOB DTX1 KBTBD8 PKHD1L1	2.29e-06	186	91	6	27d4c38b180e4ce2bf3e7c4ad3db3a2ffca05ca8
ToppCell	facs-Lung-EPCAM-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 SPIRE2 RSPH4A RP1 CFAP61 PLCH1	2.37e-06	187	91	6	051b8c07d7489ce7576f6c57ce7008767ef76869
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 SPIRE2 RSPH4A RP1 CFAP61 PLCH1	2.37e-06	187	91	6	888856cde7a69ea2f14d590597e25b1af6383c51
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D175\|Adult / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	2.37e-06	187	91	6	1e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	EFNA5 MECOM RP1 ITGA3 PLCH1 DNAH11	2.44e-06	188	91	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	2.44e-06	188	91	6	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EFNA5 NFATC1 DTX1 PCSK6 EGFL7 PKHD1L1	2.52e-06	189	91	6	55a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCell	facs-Lung-nan-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 SPIRE2 RSPH4A RP1 CFAP61 CAPS2	2.59e-06	190	91	6	e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 ITGA1 EGFL7 PKHD1L1	2.59e-06	190	91	6	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	facs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSNAXIP1 SPIRE2 RSPH4A RP1 CFAP61 CAPS2	2.59e-06	190	91	6	fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 CECR2 MECOM GCGR RP1	2.59e-06	190	91	6	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	NS-critical-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TSNAXIP1 RSPH4A RP1 CAPS2 PLCH1 DNAH11	2.92e-06	194	91	6	1ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-B_lymphocytic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	FCRL2 PARP1 HLA-DOB OTUD1 KBTBD8 PKHD1L1	3.39e-06	199	91	6	1aa963ed5205d6d52262b1597a5d08707a95c3ca
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSNAXIP1 ZNF473 RSPH4A RP1 CFAP61 DNAH11	3.48e-06	200	91	6	af6a551f83808c1c839df7ba7b1702ca28ea6e1b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSNAXIP1 ZNF473 RSPH4A RP1 CFAP61 DNAH11	3.48e-06	200	91	6	73ac1cf40ddd764be1100cbfaaa29563665457d8
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RSPH4A RP1 CFAP61 CAPS2 DNAH11	1.33e-05	148	91	5	d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCell	COVID-19-kidney-Lymphatic_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EFNA5 DTX1 PCSK6 ITGA1 PKHD1L1	1.33e-05	148	91	5	f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCell	LPS-antiTNF-Epithelial_airway-Ciliated_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RSPH4A RP1 CFAP61 CAPS2 DNAH11	1.33e-05	148	91	5	c8e93b87212f55774223caa385859c566fa1981f
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MECOM RP1 CFAP61 TRIM40 DNAH11	1.47e-05	151	91	5	8216462e723fec2797387929dde095370947e10a
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSNAXIP1 RSPH4A RP1 CFAP61 DNAH11	1.47e-05	151	91	5	81cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSNAXIP1 RSPH4A RP1 CFAP61 DNAH11	1.47e-05	151	91	5	9cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCRL2 HLA-DOB DTX1 THSD7B CCDC85A	1.72e-05	156	91	5	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIF15 CECR2 UNC13D MRPS16 CFAP61	1.77e-05	157	91	5	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	PND07-Endothelial-Endothelial_lymphatic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTX1 PCSK6 EGFL7 NFAT5 PKHD1L1	2.00e-05	161	91	5	133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTX1 PCSK6 EGFL7 NFAT5 PKHD1L1	2.00e-05	161	91	5	9466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell	PND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DTX1 PCSK6 EGFL7 NFAT5 PKHD1L1	2.00e-05	161	91	5	cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSNAXIP1 RSPH4A RP1 CFAP61 CAPS2	2.45e-05	168	91	5	fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCell	E16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TSNAXIP1 RSPH4A RP1 CFAP61 CAPS2	2.45e-05	168	91	5	7edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A1BG DTX1 GZMK IL2RA PPM1B	2.52e-05	169	91	5	18ba8fc2ba8838484d3b223428cd41568e2ccb10
ToppCell	droplet-Lung-nan-3m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAAF5 KLHDC1 DTX1 GZMK PPM1B	2.52e-05	169	91	5	9df20ce0c2661eb4b3ce4c0b857e38485fabd46d
ToppCell	droplet-Lung-nan-21m-Lymphocytic-mature_NK_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	A1BG DTX1 GZMK IL2RA PPM1B	2.52e-05	169	91	5	47a63afd80cb7ba2258ba57d3084d8b2a7bc4e8d
ToppCell	droplet-Lung-nan-3m-Lymphocytic-Natural_Killer_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAAF5 KLHDC1 DTX1 GZMK PPM1B	2.52e-05	169	91	5	7ec2b6b55f51edc0084db73eaf42ae319a24f77a
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSPH4A RP1 PLCH1 PKHD1L1 DNAH11	2.52e-05	169	91	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	10x5'-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	FCRL2 HLA-DOB DTX1 ATRNL1 PKHD1L1	2.75e-05	172	91	5	2cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCell	367C-Lymphocytic-ILC-ILC-2\|367C / Donor, Lineage, Cell class and subclass (all cells)	DHX58 PRKAR2A ITGA1 ZNF441 PPM1B	2.82e-05	173	91	5	0451450605521fecb27a958628870d268adfb023
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	3.07e-05	176	91	5	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	3.07e-05	176	91	5	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	367C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DHX58 PRKAR2A ITGA1 ZNF441 PPM1B	3.32e-05	179	91	5	5aa8465e943b6b666c7f8b1937fcc3764bfe91f6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 MECOM GCGR RP1	3.41e-05	180	91	5	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 MECOM GCGR RP1	3.41e-05	180	91	5	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	(6)_Endothelial-F_(Lymphatics)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	3.79e-05	184	91	5	03ea613e00b45c81b752c14505a0538d698f551e
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Memory_B_cells\|bone_marrow / Manually curated celltypes from each tissue	FCRL2 HLA-DOB ATRNL1 PKHD1L1 CCDC85A	3.79e-05	184	91	5	ffc9eec123de34a4f17ed27fe4f0a1b3cb84697f
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EFNA5 NFATC1 DTX1 EGFL7 PKHD1L1	3.89e-05	185	91	5	f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	EFNA5 ATRNL1 FGF1 STEAP2 PKHD1L1	3.89e-05	185	91	5	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	15-Airway-Epithelial-Multiciliated_cell\|Airway / Age, Tissue, Lineage and Cell class	RSPH4A RP1 CFAP61 CAPS2 DNAH11	3.89e-05	185	91	5	0998b6bf44287eebbf39249fff23fc3689e44c4e
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RSPH4A DTX1 PCSK6 EGFL7 PKHD1L1	3.89e-05	185	91	5	3be9e05b929ac4d956b1d53284072f668a6c1959
ToppCell	PCW_13-14-Endothelial-Endothelial_mature-lymphatic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	RSPH4A DTX1 PCSK6 EGFL7 PKHD1L1	3.89e-05	185	91	5	c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 MECOM GCGR RP1	4.09e-05	187	91	5	85e58a312fc325e4063a2d250666b99b8f99beb6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 MECOM GCGR RP1	4.09e-05	187	91	5	52b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 MECOM RP1 ITGA3 ZNF44	4.09e-05	187	91	5	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 MECOM RP1 ITGA3 ZNF44	4.09e-05	187	91	5	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 MECOM RP1 ITGA3 ZNF44	4.09e-05	187	91	5	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	droplet-Lung-LUNG-1m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 PCSK6 OTUD1 LTBP1 PKHD1L1	4.09e-05	187	91	5	9c9ae8725905ba0cfe407878006ed06c2480fb72
ToppCell	Control-Lymphocyte-B-B_intermediate\|Control / Disease, Lineage and Cell Type	FCRL2 PARP1 HLA-DOB PKHD1L1 CCDC85A	4.09e-05	187	91	5	90c9b1a51539838323325f563be4adf5fdf1b38f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 CECR2 MECOM ITGA3 HECTD1	4.09e-05	187	91	5	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	droplet-Lung-LUNG-1m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 PCSK6 OTUD1 LTBP1 PKHD1L1	4.09e-05	187	91	5	9e9460e57cdc9cd0a0de2866b140e06d0bc19a8f
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DTX1 PCSK6 OTUD1 LTBP1 PKHD1L1	4.20e-05	188	91	5	dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCell	Endothelial-endothelial_cell_of_lymph_vessel\|World / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.20e-05	188	91	5	80910dcbb51990f2baed240f319456c0d3fa2065
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FCRL2 PARP1 NFATC1 DTX1 PKHD1L1	4.20e-05	188	91	5	9a10536afa2dea34c78421d36564cfd8252afe45
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.20e-05	188	91	5	c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DTX1 PCSK6 OTUD1 LTBP1 PKHD1L1	4.20e-05	188	91	5	2ef08313087e91985bcffc46c3798470cdeec49c
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DTX1 PCSK6 OTUD1 LTBP1 PKHD1L1	4.20e-05	188	91	5	1f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.20e-05	188	91	5	2db80767903703e7e0a1a37c598f7877a909ee94
ToppCell	COVID-19-lung-Lymphatic_EC\|lung / Disease (COVID-19 only), tissue and cell type	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.31e-05	189	91	5	c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TSNAXIP1 SPIRE2 RSPH4A CFAP61 PLCH1	4.41e-05	190	91	5	9ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCell	390C-Lymphocytic-B_cell-\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FCRL2 NFATC1 HLA-DOB OTUD1 PKHD1L1	4.41e-05	190	91	5	f63c9474f23bb72f0bb1fc531342f0da04ed8b3e
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Naive_B_cells\|bone_marrow / Manually curated celltypes from each tissue	FCRL2 HLA-DOB DTX1 CECR2 PKHD1L1	4.41e-05	190	91	5	3d45d5011305f13634013d9eeb98f235517dd54e
ToppCell	normal_Lung-Endothelial_cells-Lymphatic_ECs\|normal_Lung / Location, Cell class and cell subclass	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.41e-05	190	91	5	2185db6007404a2b22325f91460dd17635be9bba
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TSNAXIP1 SPIRE2 RSPH4A CFAP61 PLCH1	4.41e-05	190	91	5	3ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.41e-05	190	91	5	6e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 CECR2 MECOM GCGR RP1	4.41e-05	190	91	5	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	390C-Lymphocytic-B_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FCRL2 NFATC1 HLA-DOB OTUD1 PKHD1L1	4.41e-05	190	91	5	53bf211f0e8a44f5adb89c43b210a1e35120b6a8
ToppCell	IPF-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.41e-05	190	91	5	ac029e73da5995221c9b9af551d85e4b835e21d6
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPIRE2 RSPH4A RP1 CFAP61 DNAH11	4.53e-05	191	91	5	649fcb62ad15de2f83e61591e43923a717664ae7
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial-lung_ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPIRE2 RSPH4A RP1 CFAP61 DNAH11	4.53e-05	191	91	5	9621e22e14ea069f22713947c9faa2d882abe5fe
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EFNA5 CECR2 MECOM MCCC1 PLCH1	4.53e-05	191	91	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AMPD3 OTUD1 KBTBD8 PELI1 DENND5A	4.53e-05	191	91	5	0b296404ebad0aadb75737f8c0462ec6934fc8bb
ToppCell	COVID-19-kidney-TAL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EFNA5 MECOM RP1 ITGA3 WDR72	4.53e-05	191	91	5	fe55475ce0666ab5122447a813dc2369e24947b8
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	MECOM ITGA1 EGFL7 PKHD1L1 CCDC85A	4.53e-05	191	91	5	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	facs-Lung-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPIRE2 RSPH4A RP1 CFAP61 DNAH11	4.53e-05	191	91	5	6a8fc9dc1a4c7115862e8f20204fa2f95e50e22f
ToppCell	IPF-Endothelial-Lymphatic\|IPF / Disease state, Lineage and Cell class	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.64e-05	192	91	5	2496edd8f3a41146d418879de9ee2ccc7857431f
ToppCell	Control-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.64e-05	192	91	5	f95fb188aa642f3d0618242a770e7c4b70544adb
ToppCell	COVID-19-lung-Lymphatic_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EFNA5 DTX1 PCSK6 EGFL7 PKHD1L1	4.64e-05	192	91	5	cbe57cda44232b183821ac633b60a2668265e616
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EFNA5 DTX1 CECR2 MECOM RP1	4.64e-05	192	91	5	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	RA-09._Endothelium_I\|RA / Chamber and Cluster_Paper	MECOM ITGA1 EGFL7 PKHD1L1 CCDC85A	4.64e-05	192	91	5	8a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	EFNA5 CECR2 MECOM MCCC1 PLCH1	4.64e-05	192	91	5	06013a07e3a873b1d1c0451643c528593ac32a9c
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	TH GLUD1 GLUD2	1.18e-06	6	90	3	CID000015362
Drug	Citric Acid	GLUD1 SYP TERT MUC5AC	5.03e-06	29	90	4	ctd:D019343
Drug	phenyltriethoxysilane	GLUD1 GLUD2	1.55e-05	2	90	2	CID000013075
Drug	G-3SH	GLUD1 GLUD2	1.55e-05	2	90	2	CID000174237
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	1.55e-05	2	90	2	CID006455327
Drug	methylmercuric bromide	GLUD1 GLUD2	1.55e-05	2	90	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	1.55e-05	2	90	2	CID000068137
Drug	x 1 s	GLUD1 GLUD2	1.55e-05	2	90	2	CID000409694
Drug	tyrosinate	TH NFATC1 GRK4 GLUD1 GLUD2 NFAT5	2.71e-05	148	90	6	CID000001153
Drug	Zinc Sulfate	TH PARP1 SEC24D DHX58 NFATC1 FGF1 EGFL7 THSD7B PLCH1 TERT PKHD1L1 PPM1B	3.37e-05	739	90	12	ctd:D019287
Drug	glicentin	PCSK6 FGF1 SYP GCGR	4.22e-05	49	90	4	CID000126332
Drug	lenthionine	GLUD1 GLUD2	4.62e-05	3	90	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	4.62e-05	3	90	2	CID000125665
Drug	methoxyethylmercury	GLUD1 GLUD2	4.62e-05	3	90	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	4.62e-05	3	90	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	4.62e-05	3	90	2	CID000067347
Drug	isovaleryl-CoA	GLUD1 GLUD2 MCCC1 DBT	5.76e-05	53	90	4	CID000000810
Drug	lithium sulfate monohydrate	GLUD1 GLUD2 MUC5AC	8.71e-05	22	90	3	CID000165815
Drug	methyl benzoquate	GLUD1 GLUD2	9.22e-05	4	90	2	CID000026383
Drug	pentenoic acid	GLUD1 GLUD2	9.22e-05	4	90	2	CID000012299
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	9.22e-05	4	90	2	CID000000048
Drug	ureidoglycine	GLUD1 GLUD2	9.22e-05	4	90	2	CID000439649
Drug	Ivin	GLUD1 GLUD2	9.22e-05	4	90	2	CID000014083
Drug	Naphthalimides	XIAP TERT	9.22e-05	4	90	2	ctd:D053644
Drug	8-BDB-TADP	GLUD1 GLUD2	9.22e-05	4	90	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	9.22e-05	4	90	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	9.22e-05	4	90	2	CID000442451
Drug	Tetanus Toxoid	PARP1 TERT	9.22e-05	4	90	2	ctd:D013745
Drug	luxabendazole	GLUD1 GLUD2	9.22e-05	4	90	2	CID000072019
Drug	N-butylmaleimide	GLUD1 GLUD2	9.22e-05	4	90	2	CID000239780
Drug	alpha-methylglutamate	GLUD1 GLUD2	9.22e-05	4	90	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	9.22e-05	4	90	2	CID005327076
Drug	Gg P	GLUD1 GLUD2 STEAP2	1.29e-04	25	90	3	CID005288387
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; MCF7; HT_HG-U133A	AMPD3 EFNA5 GRK4 PCSK6 GCGR PLCH1	1.36e-04	198	90	6	4751_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Up 200; 15uM; PC3; HT_HG-U133A	FCRL2 PCSK6 GZMK SLC17A4 SYP HAPLN1	1.40e-04	199	90	6	4259_UP
Drug	bathocuproine	GLUD1 GLUD2	1.53e-04	5	90	2	CID000065149
Drug	AC1NRA4I	GLUD1 GLUD2	1.53e-04	5	90	2	CID005287695
Drug	isosteviol lactone	GLUD1 GLUD2	1.53e-04	5	90	2	CID000401559
Drug	1-pheg	GLUD1 GLUD2	1.53e-04	5	90	2	CID000152041
Drug	5'-FSBAzA	GLUD1 GLUD2	1.53e-04	5	90	2	CID000130430
Drug	adenine N1-oxide	GLUD1 GLUD2	1.53e-04	5	90	2	CID000093557
Drug	choline sulfate	GLUD1 GLUD2	1.53e-04	5	90	2	CID000000485
Drug	l-413	GLUD1 GLUD2	1.53e-04	5	90	2	CID000012475
Drug	3-aminopicolinate	GLUD1 GLUD2	1.53e-04	5	90	2	CID000073836
Disease	anencephaly (implicated_via_orthology)	EFNA5 CECR2	2.69e-05	3	89	2	DOID:0060668 (implicated_via_orthology)
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	2.69e-05	3	89	2	DOID:885 (biomarker_via_orthology)
Disease	renal system measurement, blood urea nitrogen measurement	KBTBD8 MECOM WDR72	3.92e-05	22	89	3	EFO_0004741, EFO_0004742
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	1.34e-04	6	89	2	DOID:1825 (biomarker_via_orthology)
Disease	hyperuricemia	NFATC1 NFAT5 WDR72	1.36e-04	33	89	3	EFO_0009104
Disease	Primary ciliary dyskinesia	DNAAF5 RSPH4A DNAH11	1.76e-04	36	89	3	cv:C0008780
Disease	Lymphoid leukemia	MECOM TERT	2.49e-04	8	89	2	C0023448
Disease	Primary Ciliary Dyskinesia	DNAAF5 RSPH4A DNAH11	3.91e-04	47	89	3	C4551720
Disease	Ceroid lipofuscinosis, neuronal 1, infantile	PARP1 SYP	3.98e-04	10	89	2	C2931673
Disease	adult onset asthma	HLA-DOB UNC13D IL2RA MUC5AC	4.57e-04	118	89	4	EFO_1002011
Disease	pulmonary fibrosis	TERT MUC5AC	4.86e-04	11	89	2	EFO_0009448
Disease	pulmonary function measurement, forced expiratory volume, smoking behaviour measurement	MECOM PADI3	5.82e-04	12	89	2	EFO_0003892, EFO_0004314, EFO_0005671
Disease	Myeloproliferative disease	MECOM TERT	5.82e-04	12	89	2	C0027022
Disease	atherosclerosis	KBTBD8 SLC17A4	6.87e-04	13	89	2	EFO_0003914
Disease	idiopathic pulmonary fibrosis	KIF15 TERT MUC5AC	6.90e-04	57	89	3	EFO_0000768
Disease	ovarian neoplasm	FGF1 MECOM XIAP TERT	7.37e-04	134	89	4	C0919267
Disease	Malignant neoplasm of ovary	FGF1 MECOM XIAP TERT	8.00e-04	137	89	4	C1140680
Disease	cleft lip (is_implicated_in)	FGF1 POMT1	9.21e-04	15	89	2	DOID:9296 (is_implicated_in)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	9.21e-04	15	89	2	DOID:13413 (biomarker_via_orthology)
Disease	interstitial lung disease	THSD7B TERT MUC5AC	1.11e-03	67	89	3	EFO_0004244
Disease	white matter microstructure measurement	AMPD3 SPIRE2 NFATC1 MECOM UNC13D HAPLN1	1.19e-03	390	89	6	EFO_0005674
Disease	thyroxine measurement, triiodothyronine measurement	ZNF841 EGFL7	1.19e-03	17	89	2	EFO_0005130, EFO_0008392
Disease	Disorder of organic acid metabolism	MCCC1 DBT	1.33e-03	18	89	2	cv:C1263739
Disease	osteoarthritis, knee	AMPD3 SPIRE2 LTBP1 NFAT5	1.36e-03	158	89	4	EFO_0004616
Disease	glomerulonephritis (biomarker_via_orthology)	LTBP1 ITGA3	1.65e-03	20	89	2	DOID:2921 (biomarker_via_orthology)
Disease	Lung diseases	RSPH4A TERT DNAH11	1.71e-03	78	89	3	C0024115
Disease	gastric ulcer (biomarker_via_orthology)	IL25 MUC5AC	1.82e-03	21	89	2	DOID:10808 (biomarker_via_orthology)
Disease	susceptibility to shingles measurement	HLA-DOB ZSCAN16 TRIM40	1.91e-03	81	89	3	EFO_0008401
Disease	Splenomegaly	MECOM XIAP	2.00e-03	22	89	2	C0038002
Disease	Bronchiectasis	RSPH4A DNAH11	2.00e-03	22	89	2	C0006267
Disease	idiopathic pulmonary fibrosis (is_marker_for)	PARP1 IL2RA	2.18e-03	23	89	2	DOID:0050156 (is_marker_for)
Disease	severe acute respiratory syndrome, COVID-19	EFNA5 TMPRSS13 CECR2 GRK4 PCSK6 CCDC85A	2.36e-03	447	89	6	EFO_0000694, MONDO_0100096
Disease	uric acid measurement	NFATC1 GLUD1 KBTBD8 SLC17A4 MECOM NFAT5 WDR72	2.49e-03	610	89	7	EFO_0004761
Disease	Dwarfism	RSPH4A HAPLN1	2.58e-03	25	89	2	C0013336
Disease	myeloproliferative disorder	MECOM TERT	2.58e-03	25	89	2	EFO_0004251
Disease	Deafness	RSPH4A PJVK	2.58e-03	25	89	2	C0011053
Disease	basal cell carcinoma	SPIRE2 EGFL7 IL2RA TERT	2.61e-03	189	89	4	EFO_0004193
Disease	forced expiratory volume	AMPD3 RBBP7 GRK4 MECOM XIAP ITGA1 EGFL7 NFAT5	2.65e-03	789	89	8	EFO_0004314

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLYRCGDQPRHFAIA	B4GALT2	226	O60909
RYTGKVPCNHFTLNE	CFAP61	801	Q8NHU2
QRVYQPFLTTCDGHR	EGFL7	46	Q9UHF1
PFIQKSIYSHQCGRR	CAPS2	341	Q9BXY5
RGAQYFNTPRLRVHC	CCIN	106	Q13939
AHCQYRFTKGQSPTV	GZMK	66	P49863
VGPFTRQYRQELVHC	DNAH11	3421	Q96DT5
GCYQRRDITPQTFHS	CECR2	66	Q9BXF3
TDGPTKTYCHRRLNF	AMPD3	266	Q01432
REGECQRYKPFKQLH	PARP1	841	P09874
ARLHFPSVQKVCGRY	KLHL30	111	Q0D2K2
YCGKIFPRSANLTRH	MECOM	916	Q03112
ELIFVGPQHAGNYRC	A1BG	456	P04217
RYFQTCGNVHVLKPN	DBT	21	P11182
QRNKYRFHIIPDGNC	OTUD1	306	Q5VV17
ALVDVGNGKQRHVCY	KIF15	301	Q9NS87
PRYDASNENKHGTRC	PCSK6	236	P29122
QGPAGRVLVCAHRYT	ITGA3	131	P26006
HVYPVAAKTQLGRCF	LTBP1	546	Q14766
VQHRFVFKRCGPDGQ	GCGR	91	P47871
PVHVSFYVCNGKRKR	NFATC1	671	O95644
VCTYNGQRFHPGDVI	MUC5AC	1276	P98088
YDAKRAQVFHICGPE	PADI3	206	Q9ULW8
NHNITCKVGYPFLRR	ITGA1	881	P56199
GRVKPHGFYQACRVT	NFAT5	336	O94916
GFPRHCYLPNNEKGR	DTX1	531	Q86Y01
CNPDLRLRGHQKEGY	RBBP7	166	Q16576
LGRHFECAVAKLYPQ	KBTBD8	581	Q8NFY9
RGSSHQQQVTCYPFK	POMT1	356	Q9Y6A1
YNCGQIGHLKRSCPV	ERVK-5	546	Q9HDB9
LHYAACFGRPQVAKT	HECTD1	431	Q9ULT8
VDGVCRHNYRLGAPF	HLA-DOB	101	P13765
NHYDPTTGKFSCQVR	C1QL2	186	Q7Z5L3
QYRPQKGGICVANHT	GPAT3	216	Q53EU6
QHRTPCKGGIRYSTD	GLUD1	141	P00367
KQYNLCHRRSQDPFG	DHX58	216	Q96C10
QHCQGRFKLTEPSGY	ATRNL1	91	Q5VV63
VRNEITGHTYKFPCG	DENND5A	1031	Q6IQ26
SCPGIRQHLSGNQYK	CCDC85A	536	Q96PX6
QCVQGYRALHRGPAE	IL2RA	151	P01589
KVFYREGAQANRHTP	MCCC1	696	Q96RQ3
VGLACSQYGHIFRRP	ME2	116	P23368
PRFQRGDYHIDVCIN	EFNA5	41	P52803
PRAAHTCAVLGNKGY	KLHDC1	196	Q8N7A1
GNQEVEIARCHKGQY	PRKAR2A	321	P13861
NQTVFYRRPCHGEKG	IL25	136	Q9H293
GVSSCQDLYRKHIGP	DNAAF5	551	Q86Y56
GKYYCRADNGHVPIQ	FCRL2	271	Q96LA5
CTRVAHNYLRGEPFE	GRK4	146	P32298
NHPFISAGEKRYIVC	SLC17A4	256	Q9Y2C5
QHRTPCKGGIRYSTD	GLUD2	141	P49448
PFCAHQLAGEQGYIR	PELI1	396	Q96FA3
SHRGGNVTLPCKFYR	HAPLN1	51	P10915
GESYLCSHGRKVQPV	RP1	101	P56715
FYRIVAAHNKCPRDG	MRPS16	31	Q9Y3D3
PKPHLCGRRDVSYNN	RSPH4A	156	Q5TD94
RLHQVYFDAPTCRGG	SYP	76	P08247
GTGYICPNHQKRVCR	TRIM40	66	Q6P9F5
QRIRKGQEILHCYGP	SMYD4	561	Q8IYR2
SCKRGPRTHYGQKAI	FGF1	131	P05230
PSCYRGFQTVKHRNE	SECISBP2	116	Q96T21
RCGYHVVIGSRNPKF	STEAP2	51	Q8NFT2
PKHIYFINCGDSRAV	PPM1B	141	O75688
YLVNHGESGPVRCNR	SEC24D	351	O94855
CGKVFGYPQSLTRHR	ZNF865	611	P0CJ78
ICGKGFDYPSSVQRH	ZNF441	591	Q8N8Z8
IPRTYGKCGHENLQL	ZNF735	111	P0CB33
GHTGIRYKEQRESCP	TMPRSS13	191	Q9BYE2
GRHRKVSPNCRFING	XIAP	81	P98170
DGQKYVRLHAVPCFD	PJVK	331	Q0ZLH3
CAAFHLIVARKNGYP	REPS2	341	Q8NFH8
DPRGAQAHYQAVCRA	SPIRE2	181	Q8WWL2
SVIPHQKLFTRDGCY	ZNF587	226	Q96SQ5
ECGKIFRNPRYFSVH	ZNF274	511	Q96GC6
SVIPHQKLFTRDGCY	ZNF417	226	Q8TAU3
FYSCLRNGKNESHVP	WDR72	951	Q3MJ13
HPDGPSYDRNICQKR	PKHD1L1	2591	Q86WI1
VVEHFQRGLRNGYCK	PLCH1	1396	Q4KWH8
KPYRCNESGKAFHRG	ZNF841	171	Q6ZN19
RTHTGEKPYRCNQCG	ZNF180	401	Q9UJW8
RLHTGQRPYQCFECG	ZNF471	591	Q9BX82
RQHFRKLCYQDAPGP	ZSCAN16	41	Q9H4T2
CHDPQGKKGFRTRQR	THSD7B	501	Q9C0I4
RQIYGPECTFKASHG	TIGD5	156	Q53EQ6
DDYRKRVGSCQQHPF	TSNAXIP1	26	Q2TAA8
RTETYPDRGQCHLQF	UNC13D	266	Q70J99
KGLSYRHSFQTCERP	ZNF44	196	P15621
HAVRIRGKSYVQCQG	TERT	816	O14746
QCGKFFVSVPGVRRH	ZNF669	226	Q96BR6
IPRTYGKCGHENLQF	ZNF722	111	A0A1W2PQL4
EPYKCNERGKSFRHN	ZNF473	401	Q8WTR7
DHPGFSDQVYRQRRK	TH	221	P07101