Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Cyt_P450_E_grp-I	CYP4F8 CYP2B6 CYP27B1	4.69e-04	45	63	3	IPR002401
Domain	Cyt_P450_CS	CYP4F8 CYP2B6 CYP27B1	7.60e-04	53	63	3	IPR017972
Domain	CYTOCHROME_P450	CYP4F8 CYP2B6 CYP27B1	9.40e-04	57	63	3	PS00086
Domain	-	CYP4F8 CYP2B6 CYP27B1	9.89e-04	58	63	3	1.10.630.10
Domain	p450	CYP4F8 CYP2B6 CYP27B1	9.89e-04	58	63	3	PF00067
Domain	C2	RPGRIP1L RASA1 CC2D1B RIMS1	1.00e-03	131	63	4	PF00168
Domain	Cyt_P450	CYP4F8 CYP2B6 CYP27B1	1.09e-03	60	63	3	IPR001128
Domain	C2	RPGRIP1L RASA1 CC2D1B RIMS1	1.18e-03	137	63	4	SM00239
Domain	C2	RPGRIP1L RASA1 CC2D1B RIMS1	1.35e-03	142	63	4	PS50004
Domain	-	RPGRIP1L RASA1 CC2D1B RIMS1	1.57e-03	148	63	4	2.60.40.150
Domain	-	AMBP COL7A1	1.65e-03	18	63	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	AMBP COL7A1	1.65e-03	18	63	2	IPR020901
Domain	BPTI_KUNITZ_2	AMBP COL7A1	1.85e-03	19	63	2	PS50279
Domain	Kunitz_BPTI	AMBP COL7A1	1.85e-03	19	63	2	PF00014
Domain	BPTI_KUNITZ_1	AMBP COL7A1	1.85e-03	19	63	2	PS00280
Domain	C2_dom	RPGRIP1L RASA1 CC2D1B RIMS1	2.28e-03	164	63	4	IPR000008
Domain	ADAM_spacer1	ADAMTS19 ADAMTS15	2.71e-03	23	63	2	IPR010294
Domain	ADAM_spacer1	ADAMTS19 ADAMTS15	2.71e-03	23	63	2	PF05986
Domain	Kunitz_BPTI	AMBP COL7A1	2.71e-03	23	63	2	IPR002223
Domain	Peptidase_M12B_ADAM-TS	ADAMTS19 ADAMTS15	2.95e-03	24	63	2	IPR013273
Domain	Rho_GTPase_activation_prot	RASA1 ARHGAP36 SYDE1	3.27e-03	88	63	3	IPR008936
Domain	ACR	ADAMTS19 ADAMTS15	3.72e-03	27	63	2	SM00608
Domain	ADAM_Cys-rich	ADAMTS19 ADAMTS15	3.72e-03	27	63	2	IPR006586
Domain	Peptidase_M12B_N	ADAMTS19 ADAMTS15	7.66e-03	39	63	2	IPR002870
Domain	Pep_M12B_propep	ADAMTS19 ADAMTS15	7.66e-03	39	63	2	PF01562
Domain	DISINTEGRIN_1	ADAMTS19 ADAMTS15	8.04e-03	40	63	2	PS00427
Domain	Reprolysin	ADAMTS19 ADAMTS15	8.04e-03	40	63	2	PF01421
Domain	ADAM_MEPRO	ADAMTS19 ADAMTS15	8.04e-03	40	63	2	PS50215
Domain	DISINTEGRIN_2	ADAMTS19 ADAMTS15	8.04e-03	40	63	2	PS50214
Domain	Peptidase_M12B	ADAMTS19 ADAMTS15	8.04e-03	40	63	2	IPR001590
Domain	CYSTEINE_SWITCH	ADAMTS19 ADAMTS15	8.44e-03	41	63	2	PS00546
Domain	Disintegrin_dom	ADAMTS19 ADAMTS15	8.44e-03	41	63	2	IPR001762
Domain	Pept_M10_metallopeptidase	ADAMTS19 ADAMTS15	9.25e-03	43	63	2	IPR001818
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F8 CYP2B6 CYP27B1 NCOA1	4.58e-05	64	44	4	M5650
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F8 CYP2B6 CYP27B1 NCOA1	5.17e-05	66	44	4	MM14839
Pathway	WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY	CYP2B6 CYP27B1 ABCB11	1.09e-04	30	44	3	MM15866
Pathway	BIOCARTA_NUCLEARRS_PATHWAY	CYP2B6 CYP27B1 ABCB11	1.59e-04	34	44	3	M16393
Pathway	WP_NUCLEAR_RECEPTORS_IN_LIPID_METABOLISM_AND_TOXICITY	CYP2B6 CYP27B1 ABCB11	1.73e-04	35	44	3	M39488
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP4F8 CYP2B6 CYP27B1 NCOA1	3.02e-04	104	44	4	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	CYP4F8 CYP2B6 CYP27B1 NCOA1	3.14e-04	105	44	4	MM14842
Pubmed	STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.	BRSK2 PLK1	1.10e-05	3	67	2	33500714
Pubmed	Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.	RASA1 NFKBIA	1.10e-05	3	67	2	12151397
Pubmed	Activation of IKK/NF-κB provokes renal inflammatory responses in guanylyl cyclase/natriuretic peptide receptor-A gene-knockout mice.	NPR1 NFKBIA	2.19e-05	4	67	2	22318993
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRUNE2 TTBK1 RTEL1 SOCS5 BRSK2 CC2D1B UBN2	4.60e-05	493	67	7	15368895
Pubmed	Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1.	NFKBIA PLK1	5.46e-05	6	67	2	18957422
Pubmed	Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.	ADAMTS19 ADAMTS15	7.63e-05	7	67	2	11867212
Pubmed	Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption.	ABCB11 NCOA1	7.63e-05	7	67	2	21195347
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP4F8 CYP2B6 CYP27B1	8.55e-05	44	67	3	12745259
Pubmed	Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.	HEG1 FGF12	1.63e-04	10	67	2	22898778
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	NFATC2IP ETV3 NCOA1 UBN2 KIFC1	1.71e-04	268	67	5	33640491
Pubmed	Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.	ADAMTS19 ADAMTS15	1.99e-04	11	67	2	29337306
Pubmed	Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.	CYP27B1 NCOA1	2.81e-04	13	67	2	19255064
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	FRMD4A AMER2 MPRIP	3.00e-04	67	67	3	29254152
Pubmed	TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.	PLK1 KIFC1	3.28e-04	14	67	2	31904480
Pubmed	The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.	NFKBIA CARD10	3.78e-04	15	67	2	15125833
Pubmed	Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action.	CYP27B1 NCOA1	4.31e-04	16	67	2	10882104
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	CYP4F8 CYP2B6 CYP27B1 ABCB11	5.36e-04	193	67	4	19343046
Pubmed	Report of the sixth international workshop on human chromosome 3 mapping 1995.	COL7A1 NKTR	7.50e-04	21	67	2	8641130
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SPTBN4 RASA1 NFATC2IP MAP4K1 ADAMTS15 BSDC1 CARD10 SYDE1	7.57e-04	1021	67	8	26760575
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	CYP27B1 ABCB11 CARD10 PLK1 SLC4A2	8.51e-04	381	67	5	18676680
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	RPGRIP1L ADO NFATC2IP KDM5C UBN2 MPRIP	9.49e-04	588	67	6	38580884
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PEX6 CC2D1B TNFAIP2 SYDE1 KIFC1 SLC4A2	1.58e-03	650	67	6	38777146
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	COL7A1 ITGA7	1.75e-03	32	67	2	23154389
Pubmed	SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.	RASA1 MAP4K1	1.75e-03	32	67	2	22974441
Pubmed	Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.	ADAMTS19 ADAMTS15	1.75e-03	32	67	2	31434798
Cytoband	16p12.2	POLR3E PLK1	1.35e-03	37	67	2	16p12.2
Coexpression	GSE14000_UNSTIM_VS_16H_LPS_DC_DN	NFATC2IP NFKBIA CYP27B1 ETV3 AIDA TNFAIP2	1.14e-05	200	66	6	M3350
Drug	Itraconazole	NFKBIA CYP27B1 ABCB11 NCOA1	2.18e-06	32	66	4	ctd:D017964
Disease	gliosarcoma	CYP2B6 NFKBIA	5.28e-04	16	63	2	C0206726
Disease	cathepsin L1 measurement	TNFAIP2 SLC15A3	5.28e-04	16	63	2	EFO_0010619
Disease	alcoholic hepatitis (biomarker_via_orthology)	NFKBIA ABCB11	6.71e-04	18	63	2	DOID:12351 (biomarker_via_orthology)
Disease	Kidney Diseases	NPR1 RPGRIP1L HOXD11	8.94e-04	88	63	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
GEQEPEPILIPRVRR	AMBP	191	P02760
TRLEVERERELPPPA	SLC4A2	476	P04920
RRLNRIPIEPHPKEE	AMER2	491	Q8N7J2
ILRRQREEDPAPPKR	CARD10	531	Q9BWT7
REIEQVIGPHRPPEL	CYP2B6	326	P20813
EGQLVLERVRDTPPP	BLACE	56	A4D250
PEPRPPARVETLREE	BSDC1	346	Q9NW68
PLQPREREAVRPGVL	ADO	156	Q96SZ5
LQPPPVGRKNRERVE	ETV3	346	P41162
LPAARPEDGRPRLVV	BTBD17	381	A6NE02
PVQEEVEPAPVRRIL	ABCB11	731	O95342
RPLRRIISVEEDPLP	CRACR2A	466	Q9BSW2
DVQPVPLRRILAPGE	AIDA	111	Q96BJ3
RERVPEPQRSLRPGV	ZNF436-AS1	41	Q8NC38
PERRENGVLRPVPQK	CDADC1	486	Q9BWV3
IIERVTRGEQPPFRP	NPR1	751	P16066
PEREVVVPIRLDPDI	ADAMTS15	21	Q8TE58
PVAPPEPVEDRRRVR	RASA1	271	P20936
PIPEQDRPLLRVPRE	ARHGAP36	521	Q6ZRI8
REVRSVAPVPLEEPV	ADAMTS19	81	Q8TE59
PALVEELLRQEGPRP	CYP27B1	91	O15528
EAQPFREPGLRPRIL	ATOH8	141	Q96SQ7
PLRPEAEPGELERER	MPRIP	571	Q6WCQ1
ARPPEERVPRVAVIV	MATN4	131	O95460
IRSEEPEVVQRLPPA	RPGRIP1L	936	Q68CZ1
PDLQRLPVREVPFRE	LRRN2	401	O75325
DLPPRNEIDPPRKRV	BRSK2	351	Q8IWQ3
IRVFCRVRPVLPGEP	KIFC1	311	Q9BW19
RRGETLPVPGPRVLE	PEX6	126	Q13608
RILKPGRELPPDIRR	LARP6	231	Q9BRS8
EIRLEPQEVPRGSEP	NFKBIA	51	P25963
GLELQLERRPEREPP	HEG1	51	Q9ULI3
PPILTERGERVPKLV	KLLN	151	B2CW77
EIIVSRPIGDIPRIP	RIMS1	686	Q86UR5
PGEEPPIVRRRIGTA	FRMD4A	431	Q9P2Q2
ILPDHREPRRTPEIV	CYP4F8	491	P98187
QRELLPPAGRRPDVL	HOXD11	126	P31277
ELPERFRIRPVTPVE	C20orf85	66	Q9H1P6
RRGRKINEDEIPPPV	CC2D1B	211	Q5T0F9
RPRDVEAIPRAIINP	DCAF12L1	246	Q5VU92
VRREPETPLAVPGLR	COL7A1	591	Q02388
RRRELEPPEQQEPGE	ITGA7	956	Q13683
AREQPRVPGERQPLL	SLC15A3	6	Q8IY34
RRKEQLRVPAVPPGV	POLR3E	481	Q9NVU0
LRVPAVPPGVRIKEE	POLR3E	486	Q9NVU0
EEPELPPAIPRRIRS	MAP4K1	306	Q92918
PVRRRPEPQLKGIVT	FGF12	61	P61328
EQEPVPARQRPRGLL	RTEL1	821	Q9NZ71
LPLADPEVVTRPRGR	SYDE1	626	Q6ZW31
PILEPVDRRIPRIEN	PRUNE2	2216	Q8WUY3
ERRRLSIEEGVDPPP	SOCS5	266	O75159
EIPPVPENRFLLRRD	NKTR	286	P30414
IARRLPRPPAITGVE	NCOA1	246	Q15788
RFRDRLPTPIPGEVV	SLC26A10	221	Q8NG04
PRVDRPRKVPVIQEE	NSMCE4A	231	Q9NXX6
RRLVLDPGEAPLVPV	NFATC2IP	111	Q8NCF5
VLPPLRDVRTRPEVG	RIC8A	356	Q9NPQ8
LGPSPEQRVEIVPRD	ALKAL2	76	Q6UX46
RAPPLGNPLRLEERI	LINC01559	86	Q495D7
VLGVLRRPLEAPPER	TNFAIP2	136	Q03169
AEQPPRPPRETVRLE	UBN2	116	Q6ZU65
PEELRPLPEEGEERR	TTBK1	571	Q5TCY1
PPQEEIGLIRLLRRE	MRPL10	71	Q7Z7H8
ERLQPRIDRLPEIPG	SPTBN4	2186	Q9H254
RIDRLPEIPGRVEPA	SPTBN4	2191	Q9H254
HAEERRVPPPPERLV	nan	86	Q6ZVL8
RAEERVLVRPHEPPP	WASF1	266	Q92558
LQVIDIRRVGPREPE	TSNAXIP1	641	Q2TAA8
MEGEPPPVEERRRLQ	SNRNP48	1	Q6IEG0
LPERPREKEEPVVRE	PLK1	351	P53350
LRQRLQAEPRPEEPP	KDM5C	1311	P41229
GVRRLISVEPRPEQP	MYO1G	986	B0I1T2