Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H2AX kinase activity	BAZ1B ATM	1.04e-04	5	65	2	GO:0141003
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	SHPRH MEIOB RFC2 XRCC5 NIPBL HMCES	2.08e-04	262	65	6	GO:0140097
GeneOntologyMolecularFunction	telomeric DNA binding	SMG1 ZBTB10 XRCC5	2.98e-04	40	65	3	GO:0042162
GeneOntologyBiologicalProcess	DNA repair	NPM1 SMG1 ABL1 RNF168 USP9X SMCHD1 SHPRH MEIOB ATM RFC2 XRCC5 SMC5 NIPBL HMCES	8.91e-09	648	64	14	GO:0006281
GeneOntologyBiologicalProcess	double-strand break repair via nonhomologous end joining	RNF168 SMCHD1 ATM XRCC5 SMC5 HMCES	1.40e-07	77	64	6	GO:0006303
GeneOntologyBiologicalProcess	DNA damage response	NPM1 SMG1 ABL1 RNF168 USP9X SMCHD1 SHPRH MEIOB BAZ1B ATM RFC2 XRCC5 SMC5 NIPBL HMCES	1.73e-07	959	64	15	GO:0006974
GeneOntologyBiologicalProcess	DNA recombination	ABL1 RNF168 SMCHD1 CD40LG MEIOB ATM XRCC5 SMC5 NIPBL HMCES	1.86e-07	368	64	10	GO:0006310
GeneOntologyBiologicalProcess	double-strand break repair	ABL1 RNF168 SMCHD1 MEIOB ATM XRCC5 SMC5 NIPBL HMCES	6.72e-07	324	64	9	GO:0006302
GeneOntologyBiologicalProcess	DNA metabolic process	NPM1 SMG1 ABL1 RNF168 USP9X SMCHD1 CD40LG SHPRH MEIOB ATM RFC2 XRCC5 SMC5 NIPBL HMCES	7.95e-07	1081	64	15	GO:0006259
GeneOntologyBiologicalProcess	recombinational repair	ABL1 SMCHD1 MEIOB ATM XRCC5 SMC5 NIPBL	2.31e-06	194	64	7	GO:0000725
GeneOntologyBiologicalProcess	cellular response to X-ray	ATM XRCC5 NIPBL	4.62e-06	11	64	3	GO:0071481
GeneOntologyBiologicalProcess	chromosome organization	SMG1 ABL1 SMCHD1 MEIOB BAZ1B ATM RFC2 XRCC5 SMC5 BECN1 NIPBL	7.60e-06	686	64	11	GO:0051276
GeneOntologyBiologicalProcess	regulation of DNA metabolic process	NPM1 SMG1 ABL1 RNF168 SMCHD1 ATM RFC2 XRCC5 SMC5 HMCES	8.67e-06	564	64	10	GO:0051052
GeneOntologyBiologicalProcess	double-strand break repair via homologous recombination	ABL1 SMCHD1 MEIOB ATM SMC5 NIPBL	2.56e-05	188	64	6	GO:0000724
GeneOntologyBiologicalProcess	positive regulation of DNA metabolic process	NPM1 RNF168 SMCHD1 ATM RFC2 XRCC5 HMCES	7.57e-05	333	64	7	GO:0051054
GeneOntologyBiologicalProcess	chromosome segregation	USP9X MEIOB BAZ1B ATM SMC5 BECN1 NIPBL DSN1	9.20e-05	465	64	8	GO:0007059
GeneOntologyBiologicalProcess	response to X-ray	ATM XRCC5 NIPBL	1.09e-04	30	64	3	GO:0010165
GeneOntologyBiologicalProcess	somatic cell DNA recombination	RNF168 CD40LG ATM HMCES	1.23e-04	82	64	4	GO:0016444
GeneOntologyBiologicalProcess	somatic diversification of immune receptors via germline recombination within a single locus	RNF168 CD40LG ATM HMCES	1.23e-04	82	64	4	GO:0002562
GeneOntologyBiologicalProcess	regulation of TOR signaling	HIF1A USP9X GAS6 PKHD1 ATM	1.31e-04	158	64	5	GO:0032006
GeneOntologyBiologicalProcess	B-1 B cell homeostasis	HIF1A ABL1	1.41e-04	6	64	2	GO:0001922
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	NPM1 RNF168 INSRR VPS13A ATM XRCC5 NIPBL	1.48e-04	371	64	7	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	NPM1 RNF168 INSRR VPS13A ATM XRCC5 NIPBL	1.48e-04	371	64	7	GO:0104004
GeneOntologyBiologicalProcess	regulation of chromosome organization	SMG1 BAZ1B ATM XRCC5 SMC5 BECN1	1.74e-04	266	64	6	GO:0033044
GeneOntologyBiologicalProcess	somatic diversification of immune receptors	RNF168 CD40LG ATM HMCES	1.84e-04	91	64	4	GO:0002200
GeneOntologyBiologicalProcess	regulation of vasoconstriction	DOCK5 HIF1A ABL1 PDE5A	2.45e-04	98	64	4	GO:0019229
GeneOntologyBiologicalProcess	TOR signaling	HIF1A USP9X GAS6 PKHD1 ATM	2.47e-04	181	64	5	GO:0031929
GeneOntologyBiologicalProcess	positive regulation of stress granule assembly	HIF1A BECN1	2.62e-04	8	64	2	GO:0062029
GeneOntologyBiologicalProcess	nuclear export	NPM1 SMG1 GAS6 NXF2 DDX39A	2.73e-04	185	64	5	GO:0051168
GeneOntologyBiologicalProcess	B cell activation involved in immune response	ABL1 RNF168 CD40LG HMCES	2.75e-04	101	64	4	GO:0002312
GeneOntologyBiologicalProcess	cellular response to radiation	NPM1 RNF168 ATM XRCC5 NIPBL	3.40e-04	194	64	5	GO:0071478
GeneOntologyBiologicalProcess	protein modification by small protein conjugation	NPM1 TRIM15 HIF1A ABL1 RNF168 USP9X KLHL13 SHPRH SMC5 ZZEF1	3.99e-04	893	64	10	GO:0032446
GeneOntologyBiologicalProcess	regulation of telomere maintenance	SMG1 ATM XRCC5 SMC5	4.07e-04	112	64	4	GO:0032204
GeneOntologyBiologicalProcess	regulation of tube diameter	DOCK5 HIF1A ABL1 PDE5A ITGA1	4.09e-04	202	64	5	GO:0035296
GeneOntologyBiologicalProcess	blood vessel diameter maintenance	DOCK5 HIF1A ABL1 PDE5A ITGA1	4.09e-04	202	64	5	GO:0097746
GeneOntologyBiologicalProcess	regulation of tube size	DOCK5 HIF1A ABL1 PDE5A ITGA1	4.18e-04	203	64	5	GO:0035150
GeneOntologyBiologicalProcess	establishment of centrosome localization	PKHD1 PARD3B	4.20e-04	10	64	2	GO:0051660
GeneOntologyBiologicalProcess	post-translational protein modification	NPM1 TRIM15 HIF1A ABL1 RNF168 USP9X KLHL13 SHPRH BAZ1B SMC5 ZZEF1	4.25e-04	1074	64	11	GO:0043687
GeneOntologyBiologicalProcess	apoptotic cell clearance	XKR9 GAS6 BECN1	4.46e-04	48	64	3	GO:0043277
GeneOntologyBiologicalProcess	vasoconstriction	DOCK5 HIF1A ABL1 PDE5A	5.46e-04	121	64	4	GO:0042310
GeneOntologyBiologicalProcess	regulation of stress granule assembly	HIF1A BECN1	6.13e-04	12	64	2	GO:0062028
GeneOntologyBiologicalProcess	cellular senescence	NPM1 ABL1 ATM SMC5	6.74e-04	128	64	4	GO:0090398
GeneOntologyBiologicalProcess	maintenance of mitotic sister chromatid cohesion	SMC5 NIPBL	7.23e-04	13	64	2	GO:0034088
GeneOntologyBiologicalProcess	positive regulation of transferase activity	NPM1 ABL1 GAS6 INSRR PDE5A RFC2 XRCC5	7.89e-04	490	64	7	GO:0051347
GeneOntologyBiologicalProcess	nuclear chromosome segregation	MEIOB BAZ1B ATM BECN1 NIPBL DSN1	8.18e-04	356	64	6	GO:0098813
GeneOntologyBiologicalProcess	maintenance of sister chromatid cohesion	SMC5 NIPBL	8.42e-04	14	64	2	GO:0034086
GeneOntologyBiologicalProcess	somatic recombination of immunoglobulin genes involved in immune response	RNF168 CD40LG HMCES	8.59e-04	60	64	3	GO:0002204
GeneOntologyBiologicalProcess	somatic diversification of immunoglobulins involved in immune response	RNF168 CD40LG HMCES	8.59e-04	60	64	3	GO:0002208
GeneOntologyBiologicalProcess	isotype switching	RNF168 CD40LG HMCES	8.59e-04	60	64	3	GO:0045190
GeneOntologyBiologicalProcess	response to radiation	NPM1 HIF1A RNF168 ATM XRCC5 ZZEF1 NIPBL	9.20e-04	503	64	7	GO:0009314
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	HIF1A ABL1 USP9X GLCE GAS6 INSRR VPS13A ITGA1 BECN1 VWA2 CCN3	9.69e-04	1186	64	11	GO:0007167
GeneOntologyBiologicalProcess	engulfment of apoptotic cell	XKR9 BECN1	9.70e-04	15	64	2	GO:0043652
GeneOntologyBiologicalProcess	cellular response to interferon-alpha	GAS6 IFIT2	9.70e-04	15	64	2	GO:0035457
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	NPM1 TRIM15 HIF1A ABL1 RNF168 USP9X KLHL13 SHPRH SMC5 ZZEF1	1.03e-03	1009	64	10	GO:0070647
GeneOntologyBiologicalProcess	immune system development	ABL1 RNF168 CD40LG ATM HMCES	1.03e-03	248	64	5	GO:0002520
GeneOntologyBiologicalProcess	cellular response to chemical stress	HIF1A ABL1 VPS13A ATM XRCC5 BECN1	1.10e-03	377	64	6	GO:0062197
GeneOntologyBiologicalProcess	phosphatidylinositol phosphate biosynthetic process	SMG1 ATM BECN1	1.13e-03	66	64	3	GO:0046854
GeneOntologyCellularComponent	chromosomal region	SMCHD1 PKHD1 ZBTB10 BAZ1B ATM XRCC5 SMC5 DSN1	4.68e-05	421	65	8	GO:0098687
GeneOntologyCellularComponent	DNA repair complex	RNF168 ATM XRCC5	4.86e-05	23	65	3	GO:1990391
GeneOntologyCellularComponent	site of DNA damage	RNF168 SMCHD1 ATM XRCC5 SMC5	6.77e-05	137	65	5	GO:0090734
GeneOntologyCellularComponent	chromosome, telomeric region	SMCHD1 ZBTB10 ATM XRCC5 SMC5	2.19e-04	176	65	5	GO:0000781
GeneOntologyCellularComponent	site of double-strand break	RNF168 SMCHD1 ATM SMC5	2.77e-04	101	65	4	GO:0035861
MousePheno	decreased tumor-free survival time	SMG1 ATM BECN1	6.90e-05	21	54	3	MP:0014237
MousePheno	abnormal tumor-free survival time	SMG1 ATM BECN1	6.90e-05	21	54	3	MP:0014235
MousePheno	abnormal DNA repair	MEIOB BAZ1B ATM XRCC5 NIPBL	1.41e-04	130	54	5	MP:0008058
MousePheno	short stride length	AGA VPS13A ATM HNRNPH2	1.43e-04	69	54	4	MP:0001407
MousePheno	abnormal placenta size	NPM1 HSD17B2 CHM DDX39A NIPBL	2.07e-04	141	54	5	MP:0004258
MousePheno	upturned snout	BAZ1B NIPBL	2.18e-04	6	54	2	MP:0006411
MousePheno	abnormal placenta junctional zone morphology	COLGALT1 HSD17B2 CHM NIPBL	2.53e-04	80	54	4	MP:0008957
MousePheno	increased cellular sensitivity to ionizing radiation	HIF1A RNF168 ATM XRCC5	2.65e-04	81	54	4	MP:0004227
MousePheno	abnormal class switch recombination	RNF168 CD40LG ATM XRCC5	2.65e-04	81	54	4	MP:0004816
MousePheno	abnormal stride length	AGA VPS13A ATM HNRNPH2	2.78e-04	82	54	4	MP:0012690
Domain	ATM/Tel1	SMG1 ATM	1.16e-05	2	64	2	IPR015519
Domain	FATC	SMG1 ATM	1.15e-04	5	64	2	PF02260
Domain	FAT	SMG1 ATM	1.72e-04	6	64	2	PS51189
Domain	FATC	SMG1 ATM	1.72e-04	6	64	2	PS51190
Domain	FATC_dom	SMG1 ATM	1.72e-04	6	64	2	IPR003152
Domain	PIK_FAT	SMG1 ATM	1.72e-04	6	64	2	IPR014009
Domain	FATC	SMG1 ATM	1.72e-04	6	64	2	SM01343
Domain	ARM-type_fold	DOCK5 SMG1 USP9X HEATR1 ATM NIPBL	1.06e-03	339	64	6	IPR016024
Domain	PI3/4_kinase_CS	SMG1 ATM	1.18e-03	15	64	2	IPR018936
Domain	-	SMG1 ATM	1.34e-03	16	64	2	1.10.1070.11
Domain	PI3Kc	SMG1 ATM	1.34e-03	16	64	2	SM00146
Domain	Zinc_finger_PHD-type_CS	PHF12 SHPRH BAZ1B	1.44e-03	65	64	3	IPR019786
Domain	PI3/4_kinase_cat_dom	SMG1 ATM	1.71e-03	18	64	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 ATM	1.71e-03	18	64	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 ATM	1.71e-03	18	64	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 ATM	1.71e-03	18	64	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 ATM	1.71e-03	18	64	2	PS00916
Domain	HEAT_REPEAT	SMG1 HEATR1 NIPBL	1.78e-03	70	64	3	PS50077
Domain	VWA	ITGA1 XRCC5 VWA2	3.00e-03	84	64	3	SM00327
Domain	PHD	PHF12 SHPRH BAZ1B	3.53e-03	89	64	3	SM00249
Domain	Znf_PHD	PHF12 SHPRH BAZ1B	3.76e-03	91	64	3	IPR001965
Domain	ZF_PHD_2	PHF12 SHPRH BAZ1B	4.24e-03	95	64	3	PS50016
Domain	ZF_PHD_1	PHF12 SHPRH BAZ1B	4.37e-03	96	64	3	PS01359
Domain	VWF_A	ITGA1 XRCC5 VWA2	4.76e-03	99	64	3	IPR002035
Pathway	WP_NIPBL_ROLE_IN_DNA_DAMAGE_CORNELIA_DE_LANGE_SYNDROME	RNF168 ATM NIPBL	1.92e-06	8	47	3	M42528
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	ABL1 RNF168 BAZ1B ATM RFC2 XRCC5	8.43e-06	146	47	6	MM15292
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR	ABL1 RNF168 BAZ1B ATM RFC2 XRCC5	2.01e-05	170	47	6	M27582
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE	ABL1 RNF168 BAZ1B ATM	3.76e-05	57	47	4	MM15298
Pathway	PID_BARD1_PATHWAY	NPM1 ATM XRCC5	1.19e-04	29	47	3	M258
Pathway	REACTOME_DNA_DOUBLE_STRAND_BREAK_RESPONSE	ABL1 RNF168 BAZ1B ATM	1.29e-04	78	47	4	M27589
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	ABL1 ATM RFC2	2.30e-04	36	47	3	MM15281
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	ABL1 ATM RFC2	2.49e-04	37	47	3	M27568
Pathway	REACTOME_DNA_REPAIR	ABL1 RNF168 BAZ1B ATM RFC2 XRCC5	4.63e-04	301	47	6	MM15433
Pathway	REACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ	RNF168 ATM XRCC5	5.08e-04	47	47	3	MM15296
Pathway	KEGG_MEDICUS_REFERENCE_LOADING_OF_THE_SMC5_SMC6_COMPLEX	RNF168 SMC5	5.87e-04	11	47	2	M47947
Pathway	REACTOME_HOMOLOGY_DIRECTED_REPAIR	ABL1 RNF168 ATM RFC2	5.91e-04	116	47	4	MM15294
Pathway	REACTOME_DNA_REPAIR	ABL1 RNF168 BAZ1B ATM RFC2 XRCC5	7.76e-04	332	47	6	M15434
Pathway	KEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING	RNF168 ATM	8.29e-04	13	47	2	M47832
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	NPM1 GTF3C1 USP9X SMCHD1 RFC2 XRCC5 DDX39A NIPBL HNRNPH2	1.18e-08	332	65	9	32786267
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	SMG1 ABL1 RNF168 ATM RFC2 XRCC5 NIPBL	1.87e-08	157	65	7	30686591
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	NPM1 AFAP1 SMCHD1 U2SURP BAZ1B HEATR1 COLGALT1 RFC2 XRCC5 DDX39A HNRNPH2	3.74e-08	660	65	11	32780723
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DOCK5 NPM1 HIF1A RNF168 GTF3C1 PHF12 SMCHD1 U2SURP BAZ1B HEATR1 RFC2 XRCC5 NIPBL HNRNPH2	9.39e-08	1294	65	14	30804502
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RNF168 GTF3C1 PHF12 SMCHD1 SHPRH ZBTB10 BAZ1B RFC2 XRCC5 NIPBL	1.87e-07	608	65	10	36089195
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	SMCHD1 U2SURP BAZ1B XRCC5 SMC5 DDX39A NIPBL HNRNPH2	2.39e-07	340	65	8	29478914
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NPM1 GTF3C1 USP9X SMCHD1 U2SURP BAZ1B HEATR1 ATM XRCC5 NIPBL	3.59e-07	653	65	10	22586326
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NPM1 GTF3C1 SMCHD1 U2SURP ZBTB10 BAZ1B HEATR1 COLGALT1 RFC2 XRCC5 DDX39A NIPBL HNRNPH2	1.10e-06	1353	65	13	29467282
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	NPM1 GTF3C1 PHF12 SMCHD1 U2SURP ZBTB10 XRCC5 DDX39A HNRNPH2	1.36e-06	583	65	9	29844126
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NPM1 GTF3C1 SMCHD1 BAZ1B HEATR1 RFC2 XRCC5 SMC5 DDX39A BECN1	1.40e-06	759	65	10	35915203
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NPM1 SMG1 GTF3C1 USP9X ZBTB10 XRCC5 THAP12 HNRNPH2	1.65e-06	440	65	8	34244565
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NPM1 GTF3C1 USP9X SMCHD1 U2SURP BAZ1B HEATR1 RFC2 XRCC5 NIPBL HNRNPH2	2.86e-06	1024	65	11	24711643
Pubmed	SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress.	SMG1 ATM	3.44e-06	2	65	2	31565865
Pubmed	hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.	SMG1 ATM	3.44e-06	2	65	2	18332866
Pubmed	ERK signaling controls productive HIF-1 binding to chromatin and cancer cell adaptation to hypoxia through HIF-1α interaction with NPM1.	NPM1 HIF1A	3.44e-06	2	65	2	34388291
Pubmed	Mitochondrial dysfunction in ataxia-telangiectasia.	ATM BECN1	3.44e-06	2	65	2	22144182
Pubmed	The role of Beclin 1 in IR-induced crosstalk between autophagy and G2/M cell cycle arrest.	ATM BECN1	3.44e-06	2	65	2	31260798
Pubmed	Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia.	SMG1 HIF1A	3.44e-06	2	65	2	19406746
Pubmed	Beclin-1 and hypoxia-inducible factor-1α genes expression: Potential biomarkers in acute leukemia patients.	HIF1A BECN1	3.44e-06	2	65	2	27002764
Pubmed	Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression.	HIF1A BECN1	3.44e-06	2	65	2	19130303
Pubmed	Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma.	HIF1A BECN1	3.44e-06	2	65	2	25596085
Pubmed	Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation.	HIF1A BECN1	3.44e-06	2	65	2	25115400
Pubmed	Developmental cell death in the liver and newborn lethality of Ku86 deficient mice suppressed by antioxidant N-acetyl-cysteine.	ATM XRCC5	3.44e-06	2	65	2	16916625
Pubmed	Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion.	SEMA4B HIF1A	3.44e-06	2	65	2	24474252
Pubmed	Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development.	ABL1 ATM	3.44e-06	2	65	2	14519491
Pubmed	Interaction between ATM protein and c-Abl in response to DNA damage.	ABL1 ATM	3.44e-06	2	65	2	9168117
Pubmed	Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma.	HIF1A BECN1	3.44e-06	2	65	2	20150769
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	GTF3C1 AGA USP9X U2SURP SHPRH ATM SMC5 ANO3	4.06e-06	497	65	8	36774506
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK5 DNAH3 GTF3C1 VPS13A PKHD1 SNX31 ATM XRCC5 ZZEF1	9.00e-06	736	65	9	29676528
Pubmed	ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.	ATM BECN1	1.03e-05	3	65	2	32187724
Pubmed	Expression of CDK13 Was Associated with Prognosis and Expression of HIF-1α and beclin1 in Breast Cancer Patients.	HIF1A BECN1	1.03e-05	3	65	2	33292020
Pubmed	SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres.	SMCHD1 ATM	1.03e-05	3	65	2	32080884
Pubmed	Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.	ABL1 ATM	1.03e-05	3	65	2	11003672
Pubmed	CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM.	CD40LG ATM	1.03e-05	3	65	2	30082430
Pubmed	RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.	RNF168 ATM	1.03e-05	3	65	2	32502756
Pubmed	Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex.	ATM XRCC5	1.03e-05	3	65	2	15371510
Pubmed	c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA Repair.	ABL1 ATM	1.03e-05	3	65	2	33019757
Pubmed	Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.	HIF1A ATM	1.03e-05	3	65	2	29860718
Pubmed	ATM is required for efficient recombination between immunoglobulin switch regions.	ATM XRCC5	1.03e-05	3	65	2	15520243
Pubmed	[Potentials of DNA-PKcs, Ku80, and ATM in enhancing radiosensitivity of cervical carcinoma cells].	ATM XRCC5	1.03e-05	3	65	2	17626748
Pubmed	Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer.	HIF1A GAS6	1.03e-05	3	65	2	22516347
Pubmed	Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.	ABL1 ATM	1.03e-05	3	65	2	17409407
Pubmed	A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway.	HIF1A PDE5A	1.03e-05	3	65	2	20413734
Pubmed	Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells.	ABL1 ATM	1.03e-05	3	65	2	12650908
Pubmed	Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.	ABL1 ATM	1.03e-05	3	65	2	11375976
Pubmed	Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway.	HIF1A XRCC5	1.03e-05	3	65	2	31023624
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATM	1.03e-05	3	65	2	15279777
Pubmed	Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation.	ABL1 ATM	1.03e-05	3	65	2	9168116
Pubmed	ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks.	ATM XRCC5	1.03e-05	3	65	2	32890395
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	NPM1 GTF3C1 USP9X SMCHD1 U2SURP BAZ1B HEATR1 ATM COLGALT1 RFC2 XRCC5 NIPBL	1.15e-05	1425	65	12	30948266
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	NPM1 SMG1 GTF3C1 USP9X SMCHD1 BAZ1B RFC2 XRCC5 DSN1 HNRNPH2	1.22e-05	971	65	10	33306668
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	NPM1 SMG1 GTF3C1 SMCHD1 U2SURP VPS13A PKHD1 HEATR1 ATM XRCC5 DDX39A NIPBL	1.29e-05	1442	65	12	35575683
Pubmed	Nucleolar proteome dynamics.	NPM1 BAZ1B ATM RFC2 XRCC5 DDX39A NIPBL	1.34e-05	419	65	7	15635413
Pubmed	Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription.	ABL1 XRCC5 DDX39A	1.57e-05	26	65	3	24140708
Pubmed	Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta.	ABL1 ATM	2.06e-05	4	65	2	15289456
Pubmed	Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.	ATM XRCC5	2.06e-05	4	65	2	11158303
Pubmed	Nucleophosmin sets a threshold for p53 response to UV radiation.	NPM1 ATM	2.06e-05	4	65	2	15082766
Pubmed	Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80.	ATM XRCC5	2.06e-05	4	65	2	32944396
Pubmed	Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.	ABL1 USP9X	2.06e-05	4	65	2	21248063
Pubmed	Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells.	HIF1A XRCC5	2.06e-05	4	65	2	15272235
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	SMG1 ATM	2.06e-05	4	65	2	15175154
Pubmed	Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast.	HIF1A CCN3	2.06e-05	4	65	2	20237132
Pubmed	Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1γ in human cells.	RNF168 NIPBL	2.06e-05	4	65	2	21784059
Pubmed	Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.	ABL1 ATM	2.06e-05	4	65	2	17992189
Pubmed	Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.	ATM XRCC5	2.06e-05	4	65	2	28109743
Pubmed	mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.	HIF1A ATM	2.06e-05	4	65	2	21095582
Pubmed	A positive role for c-Abl in Atm and Atr activation in DNA damage response.	ABL1 ATM	2.06e-05	4	65	2	20798688
Pubmed	Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.	ABL1 ATM	2.06e-05	4	65	2	10212258
Pubmed	ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.	RNF168 ATM	2.06e-05	4	65	2	20550933
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	NPM1 SMCHD1 BAZ1B NIPBL	2.10e-05	86	65	4	37253089
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	RNF168 GTF3C1 PHF12 SMCHD1 ATM SMC5 DSN1	2.20e-05	453	65	7	29656893
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	NPM1 GTF3C1 U2SURP ZBTB10 BAZ1B HEATR1 RFC2 XRCC5 DDX39A	2.73e-05	847	65	9	35850772
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	NPM1 DNAH3 USP9X U2SURP RFC2 XRCC5 DDX39A ZNF804A NIPBL	2.73e-05	847	65	9	35235311
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	NPM1 SMCHD1 BAZ1B HEATR1 RFC2 XRCC5 DDX39A NIPBL	2.88e-05	652	65	8	31180492
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	NPM1 SMCHD1 U2SURP BAZ1B IRAK1BP1 HEATR1 RFC2 XRCC5 DDX39A NIPBL HNRNPH2	3.03e-05	1318	65	11	30463901
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	GTF3C1 USP9X XRCC5 DDX39A	3.11e-05	95	65	4	29490077
Pubmed	BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.	ATM XRCC5	3.43e-05	5	65	2	20668194
Pubmed	Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.	HIF1A BECN1	3.43e-05	5	65	2	19273585
Pubmed	BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.	RNF168 ATM	3.43e-05	5	65	2	24732096
Pubmed	RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.	ATM XRCC5	3.43e-05	5	65	2	26833222
Pubmed	Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression.	HIF1A PDE5A	3.43e-05	5	65	2	24614760
Pubmed	Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit.	ABL1 XRCC5	3.43e-05	5	65	2	9312071
Pubmed	Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.	ATM XRCC5	3.43e-05	5	65	2	11248063
Pubmed	HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells.	HIF1A USP9X	3.43e-05	5	65	2	34592152
Pubmed	Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling.	HIF1A PDE5A	3.43e-05	5	65	2	18641057
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	GTF3C1 USP9X PHF12 SMCHD1 U2SURP ZBTB10 RFC2 XRCC5	3.49e-05	670	65	8	22990118
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	NPM1 PHF12 BAZ1B NIPBL DSN1	4.71e-05	210	65	5	16565220
Pubmed	Role of the translationally controlled tumor protein in DNA damage sensing and repair.	ATM XRCC5	5.13e-05	6	65	2	22451927
Pubmed	DNA-PK suppresses a p53-independent apoptotic response to DNA damage.	ATM XRCC5	5.13e-05	6	65	2	19057578
Pubmed	Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.	HIF1A GAS6	5.13e-05	6	65	2	25187556
Pubmed	ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.	HIF1A ABL1	5.13e-05	6	65	2	37040401
Pubmed	Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages.	XRCC5 BECN1	5.13e-05	6	65	2	28431397
Pubmed	Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase-dependent mechanism.	ABL1 ATM	5.13e-05	6	65	2	28842482
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SMCHD1 U2SURP ZBTB10 XRCC5 HNRNPH2	5.87e-05	220	65	5	35785414
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	GTF3C1 SMCHD1 BAZ1B HEATR1 RFC2 NIPBL HNRNPH2	6.17e-05	533	65	7	30554943
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	GTF3C1 USP9X SMCHD1 RFC2 XRCC5 HMCES HNRNPH2	6.24e-05	534	65	7	35032548
Pubmed	Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm.	ABL1 ATM	7.18e-05	7	65	2	11040211
Pubmed	The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.	RNF168 XRCC5	7.18e-05	7	65	2	22266820
Pubmed	Synthetic lethality between PAXX and XLF in mammalian development.	ATM XRCC5	7.18e-05	7	65	2	27798842
Pubmed	Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.	ATM XRCC5	7.18e-05	7	65	2	25818648
Interaction	CENPA interactions	NPM1 GTF3C1 SMCHD1 SHPRH ZBTB10 BAZ1B RFC2 XRCC5 DDX39A NIPBL DSN1	2.60e-08	377	64	11	int:CENPA
Interaction	BRCA2 interactions	NPM1 SMG1 ABL1 RNF168 AGA ATM RFC2 XRCC5 SMC5 NIPBL DSN1	3.14e-08	384	64	11	int:BRCA2
Interaction	SUMO2 interactions	NPM1 RNF168 GTF3C1 USP9X SMCHD1 BAZ1B RFC2 XRCC5 SMC5 DDX39A NIPBL HNRNPH2	2.96e-07	591	64	12	int:SUMO2
Interaction	PARP1 interactions	NPM1 HIF1A ABL1 RNF168 GTF3C1 SMCHD1 U2SURP SHPRH ZBTB10 BAZ1B HEATR1 ATM RFC2 XRCC5 SMC5 DDX39A NIPBL	4.71e-07	1316	64	17	int:PARP1
Interaction	MDC1 interactions	RNF168 GTF3C1 PHF12 SMCHD1 U2SURP ATM RFC2 XRCC5 SMC5 DSN1	6.76e-07	414	64	10	int:MDC1
Interaction	BRCA1 interactions	NPM1 HIF1A AFAP1 ABL1 RNF168 USP9X PHF12 SMCHD1 ATM RFC2 XRCC5 SMC5 DDX39A BECN1 NIPBL HNRNPH2	1.24e-06	1249	64	16	int:BRCA1
Interaction	ZNF330 interactions	NPM1 GTF3C1 SMCHD1 SHPRH ZBTB10 BAZ1B HEATR1 RFC2 NIPBL CCN3	1.33e-06	446	64	10	int:ZNF330
Interaction	H3C3 interactions	RNF168 GTF3C1 PHF12 SMCHD1 SHPRH ZBTB10 BAZ1B RFC2 XRCC5 NIPBL	3.37e-06	495	64	10	int:H3C3
Interaction	H3C1 interactions	NPM1 GTF3C1 SMCHD1 U2SURP SHPRH ZBTB10 BAZ1B ATM RFC2 XRCC5 SMC5 ZZEF1 NIPBL	4.13e-06	901	64	13	int:H3C1
Interaction	NUPR1 interactions	NPM1 AFAP1 SMCHD1 U2SURP BAZ1B HEATR1 COLGALT1 RFC2 XRCC5 DDX39A HNRNPH2	9.06e-06	683	64	11	int:NUPR1
Interaction	HECTD1 interactions	NPM1 HIF1A GTF3C1 USP9X SMCHD1 U2SURP BAZ1B HEATR1 RFC2 XRCC5 SMC5 DDX39A BECN1	1.07e-05	984	64	13	int:HECTD1
Interaction	DCPS interactions	SMCHD1 U2SURP BAZ1B XRCC5 SMC5 DDX39A NIPBL HNRNPH2	3.38e-05	394	64	8	int:DCPS
Interaction	CIC interactions	NPM1 GTF3C1 PHF12 SMCHD1 U2SURP ZBTB10 XRCC5 SMC5 DDX39A HNRNPH2	4.80e-05	673	64	10	int:CIC
Interaction	HMGA1 interactions	NPM1 HIF1A USP9X BAZ1B ATM RFC2 XRCC5 SMC5	5.22e-05	419	64	8	int:HMGA1
Interaction	BIN1 interactions	ABL1 SMCHD1 ITGA1 XRCC5 BECN1	5.60e-05	129	64	5	int:BIN1
Interaction	MSH5 interactions	ABL1 PDE5A XRCC5	6.68e-05	25	64	3	int:MSH5
Interaction	CHAF1A interactions	NPM1 USP9X RFC2 XRCC5 SMC5 BECN1 DSN1	7.09e-05	322	64	7	int:CHAF1A
Interaction	MINDY4 interactions	NPM1 GTF3C1 USP9X DDX39A	8.54e-05	73	64	4	int:MINDY4
Interaction	MACROH2A1 interactions	NPM1 RNF168 GTF3C1 USP9X PHF12 U2SURP XRCC5 SMC5	9.71e-05	458	64	8	int:MACROH2A1
Interaction	HNRNPCP2 interactions	SMC5 DDX39A	9.87e-05	5	64	2	int:HNRNPCP2
Interaction	SIRT7 interactions	NPM1 GTF3C1 USP9X SMCHD1 U2SURP BAZ1B HEATR1 ATM XRCC5 NIPBL	1.10e-04	744	64	10	int:SIRT7
Interaction	NUTM2A interactions	SMC5 DDX39A	1.48e-04	6	64	2	int:NUTM2A
Interaction	SIRT6 interactions	NPM1 SMG1 HIF1A GTF3C1 USP9X ZBTB10 XRCC5 THAP12 HNRNPH2	1.56e-04	628	64	9	int:SIRT6
Interaction	LMNA interactions	NPM1 NALCN SLC35B4 SMCHD1 U2SURP BAZ1B ATM COLGALT1 RFC2 SMC5 IFIT2 NIPBL HNRNPH2	1.69e-04	1286	64	13	int:LMNA
Interaction	PCNA interactions	ABL1 SHPRH BAZ1B ATM RFC2 XRCC5 NIPBL DSN1	1.70e-04	497	64	8	int:PCNA
Interaction	BCL10 interactions	RNF168 USP9X ATM CCDC180	1.93e-04	90	64	4	int:BCL10
Interaction	TOP2B interactions	NPM1 BAZ1B ATM XRCC5 SMC5 BECN1	1.97e-04	266	64	6	int:TOP2B
Interaction	TSACC interactions	NPM1 DDX39A	2.06e-04	7	64	2	int:TSACC
Interaction	CCDC8 interactions	NPM1 GTF3C1 USP9X SMCHD1 BAZ1B HEATR1 RFC2 XRCC5 NIPBL	2.16e-04	656	64	9	int:CCDC8
Interaction	HNRNPCL2 interactions	SMCHD1 U2SURP INSRR BAZ1B RFC2 SMC5	2.32e-04	274	64	6	int:HNRNPCL2
Interaction	NFAT5 interactions	ABL1 SHPRH ATM	2.38e-04	38	64	3	int:NFAT5
Interaction	SLF2 interactions	GLCE ITGA1 SMC5	2.38e-04	38	64	3	int:SLF2
Interaction	FZR1 interactions	NPM1 SMG1 HIF1A GTF3C1 USP9X SMCHD1 BAZ1B RFC2 XRCC5 BECN1 DSN1 HNRNPH2	2.79e-04	1172	64	12	int:FZR1
Interaction	FBXO22 interactions	GTF3C1 AGA USP9X U2SURP SHPRH ATM SMC5 ANO3	2.99e-04	540	64	8	int:FBXO22
Interaction	UCHL3 interactions	USP9X ATM XRCC5 DDX39A HNRNPH2	3.04e-04	185	64	5	int:UCHL3
GeneFamily	PHD finger proteins	PHF12 SHPRH BAZ1B	1.27e-03	90	43	3	88
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL13 ZBTB8B ZBTB10	3.96e-03	134	43	3	861
Coexpression	CALVET_IRINOTECAN_SENSITIVE_VS_RESISTANT_UP	CD40LG ATM RFC2	1.45e-07	5	65	3	M17456
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	HIF1A AFAP1 GALK2 USP9X SMCHD1 U2SURP VPS13A BAZ1B SMC5 ZZEF1 ZNF804A NIPBL	1.12e-06	856	65	12	M4500
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	NPM1 HIF1A SMCHD1 VPS13A IRAK1BP1 SMC5 IFIT2 NIPBL HNRNPH2	5.55e-06	523	65	9	M12707
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	NPM1 HIF1A SMCHD1 VPS13A IRAK1BP1 SMC5 IFIT2 NIPBL HNRNPH2	6.56e-06	534	65	9	MM1054
Coexpression	SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP	SMCHD1 KLHL13 ZBTB10 PDE5A SMC5 IFIT2 ZNF804A	6.33e-05	404	65	7	M19488
Coexpression	SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_50_TO_60DY_UP	HIF1A AFAP1 PHF12 ATM HMCES	6.35e-05	169	65	5	M40877
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	SMG1 GTF3C1 USP9X BAZ1B ATM	8.55e-05	180	65	5	M8239
Coexpression	JISON_SICKLE_CELL_DISEASE_DN	NPM1 USP9X VPS13A ATM SMC5	9.98e-05	186	65	5	M4911
Coexpression	PUJANA_BREAST_CANCER_LIT_INT_NETWORK	NPM1 ABL1 ATM RFC2	1.17e-04	101	65	4	M15356
Coexpression	GSE1740_MCSF_VS_MCSF_AND_IFNG_DAY2_DERIVED_MACROPHAGE_DN	DOCK5 ABL1 USP9X GLCE ZZEF1	1.37e-04	199	65	5	M6157
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_ACT_IN_MAST_CELL_DN	ABL1 SLC35B4 INSRR CD40LG IFIT2	1.37e-04	199	65	5	M7341
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_6H_BMDC_UP	NPM1 GALK2 ABL1 SHPRH COLGALT1	1.40e-04	200	65	5	M3970
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	AFAP1 USP9X SMCHD1 U2SURP VPS13A SMC5 ZNF804A	1.54e-04	466	65	7	M13522
Coexpression	DODD_NASOPHARYNGEAL_CARCINOMA_UP	NPM1 SMG1 AFAP1 U2SURP BAZ1B HEATR1 ITGA1 COLGALT1 XRCC5 DDX39A DSN1 CCN3	1.56e-04	1407	65	12	M14427
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLHL13 SNX31 PARD3B HSD17B2 IFIT2	1.29e-06	129	65	5	6bc85761dea1f97c19bb379a99e4daf85d53201e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLHL13 SNX31 PARD3B IFIT2	6.37e-06	82	65	4	42017b8ace6f142a8358213c95a2632226c3a867
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 USP9X SMCHD1 ITGA1 NIPBL	8.14e-06	188	65	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ZNF804A ANO3	9.96e-06	196	65	5	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ZNF804A ANO3	9.96e-06	196	65	5	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A AFAP1 USP9X HNRNPH2	1.05e-05	198	65	5	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	NALCN KLHL13 GAS6 PDE5A ITGA1	1.10e-05	200	65	5	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	Substantia_nigra-Neuronal-Excitatory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PROKR2 ZBTB8B ZNF804A ANO3	2.69e-05	118	65	4	9f1d744f46d79ff2ab7f168f54fdbd9f4640dddd
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLHL13 SNX31 PARD3B IFIT2	2.97e-05	121	65	4	2ae870f822488799cd0ad85e7f72af64e33a867f
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Mme_Fam114a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	AFAP1 KLHL13 HSD17B2 IFIT2	4.30e-05	133	65	4	fc319644868078ea0f88a71d55f5e858c6848b50
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Eya1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KLHL13 PARD3B HSD17B2 IFIT2	4.42e-05	134	65	4	657ad905b40ec3f82acdef824431b8276d291ef7
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 SMCHD1 SNX31 ITGA1	6.34e-05	147	65	4	94998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c09-GZMK-FOS_l\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD40LG TMEM63C HEATR1 ITGA1	8.39e-05	158	65	4	5775246e192629058ed89fb56031bdf4cbb9c15c
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	XKR9 KLHL13 CD40LG SLFN14	9.92e-05	165	65	4	ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	AFAP1 KLHL13 PDE5A ZNF804A	1.04e-04	167	65	4	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)\|Striatum / BrainAtlas - Mouse McCarroll V32	U2SURP TMEM63C SMC5 BECN1	1.09e-04	169	65	4	c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--\|Striatum / BrainAtlas - Mouse McCarroll V32	U2SURP TMEM63C SMC5 BECN1	1.09e-04	169	65	4	5375eb52ebadccb7bfff997a11985f23e81014d6
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-\|Striatum / BrainAtlas - Mouse McCarroll V32	U2SURP TMEM63C SMC5 BECN1	1.09e-04	169	65	4	1c132d21255f5a5174ac38db4e91927f9093418e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NALCN PDE5A ITGA1 ANO3	1.24e-04	175	65	4	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMCHD1 BAZ1B ITGA1 IFIT2	1.33e-04	178	65	4	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	normal-na-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	NPM1 SMCHD1 CD40LG ATM	1.33e-04	178	65	4	fa3585383a1e7da460c88a802aaa81246d681b6b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 NALCN PARD3B ZNF804A	1.36e-04	179	65	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 NALCN PARD3B ZNF804A	1.42e-04	181	65	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SMG1 SMCHD1 VPS13A ATM	1.42e-04	181	65	4	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 NALCN PARD3B ZNF804A	1.42e-04	181	65	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 NALCN PARD3B ZNF804A	1.48e-04	183	65	4	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN SNX31 ITGA1 ANO3	1.48e-04	183	65	4	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 NALCN PARD3B ZNF804A	1.48e-04	183	65	4	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 SMCHD1 BAZ1B NIPBL	1.51e-04	184	65	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 SMCHD1 ITGA1 NIPBL	1.54e-04	185	65	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NALCN KLHL13 PDE5A ITGA1	1.54e-04	185	65	4	e64e8c98dd88d91f6501d3fb10b60fd2f3c90af3
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NALCN KLHL13 PDE5A ITGA1	1.57e-04	186	65	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	SMG1 SMCHD1 PARD3B ITGA1	1.57e-04	186	65	4	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.64e-04	188	65	4	b2d68a32314e9b099ed74d974079ad96359d1ae3
ToppCell	ASK454-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	GLCE CD40LG ZZEF1 HMCES	1.67e-04	189	65	4	316c857dec9383823e09f966bca62d52d933b141
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN ITGA1 ZNF804A ANO3	1.71e-04	190	65	4	2e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN ITGA1 ZNF804A ANO3	1.71e-04	190	65	4	0028f886c789ba238c031eae5d96acaed4af8c25
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.74e-04	191	65	4	107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.74e-04	191	65	4	bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN SNX31 ITGA1 ANO3	1.78e-04	192	65	4	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE5A PARD3B ITGA1 ANO3	1.78e-04	192	65	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIM15 TMEM63C HSD17B2 ANO3	1.78e-04	192	65	4	4a2c82e7af700ae6f04742027877768b151f5d81
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2-Excitatory_Neuron.Slc17a7-Slc17a6.Fezf2-Htr2c_(Layer_5,_Retrosplenial_cortex_(RSG)_and_Subiculum,_Tshz2+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PROKR2 SSTR5 CCDC180	1.80e-04	75	65	3	f225f053d899db133d50e878e8ec04f2a149b93c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPM1 SMCHD1 CD40LG ATM	1.81e-04	193	65	4	2901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 SMCHD1 VPS13A ATM	1.81e-04	193	65	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NPM1 SMCHD1 CD40LG ATM	1.81e-04	193	65	4	f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NPM1 SMCHD1 CD40LG ATM	1.81e-04	193	65	4	f8af695457d2a0a911a5ac491742465864ebda37
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NPM1 SMCHD1 CD40LG ATM	1.81e-04	193	65	4	089aece40130034a89a5213be778f10b0787eeba
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NALCN PDE5A ITGA1 ANO3	1.85e-04	194	65	4	8fae8061b350336299aa81f378e07deadbd55123
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NALCN PDE5A ITGA1 ANO3	1.85e-04	194	65	4	4d7d24390fdb379f943ddcc70a63f23955e10163
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.85e-04	194	65	4	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.88e-04	195	65	4	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X INSRR VPS13A PDE5A	1.88e-04	195	65	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.92e-04	196	65	4	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN PDE5A ITGA1 ANO3	1.92e-04	196	65	4	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM15 SNX31 SSTR5	1.95e-04	77	65	3	9a29879348b32b6c2302820f75fd55efba39aae8
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4-Inhibitory_Neuron.Gad1Gad2_Sst.Rbp4_(Interneuron,_OLM2_(CA1_enriched?))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM15 SNX31 SSTR5	1.95e-04	77	65	3	c5262a0d2040b2c580601e5a8d1ec626a0c7b560
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Rbp4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TRIM15 SNX31 SSTR5	1.95e-04	77	65	3	3763b55e5ce44b844da661e9024c9f2c847ea26f
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 SMCHD1 VPS13A ATM	1.96e-04	197	65	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NALCN ITGA1 HSD17B2 ANO3	1.96e-04	197	65	4	80e153790cef37b743e22a7370ff5b3a6abf147d
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A USP9X HNRNPH2	2.00e-04	198	65	4	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	Control_saline-Epithelial_airway\|Control_saline / Treatment groups by lineage, cell group, cell type	DNAH3 HSD17B2 CCDC180 ANO3	2.00e-04	198	65	4	e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCell	Control_saline-Epithelial_airway-airway_epithelial\|Control_saline / Treatment groups by lineage, cell group, cell type	DNAH3 HSD17B2 CCDC180 ANO3	2.00e-04	198	65	4	e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A USP9X HNRNPH2	2.00e-04	198	65	4	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 SMCHD1 VPS13A ATM	2.04e-04	199	65	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	facs-Tongue-nan-3m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 HIF1A USP9X HNRNPH2	2.04e-04	199	65	4	8d50e1ee58710d896c0204937331d9f4dcd38de0
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-CD4+_T_naive\|ICU-NoSEP / Disease, condition lineage and cell class	NPM1 CD40LG ZBTB10 PARD3B	2.04e-04	199	65	4	4cb6faa6ea5d6d36b9969822f572f7a7b3855dad
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPM1 RFC2 DDX39A HMCES	2.04e-04	199	65	4	8b7f84a1e385c6a9bd45a5d41f75e30819dbe32d
ToppCell	Control-Control-Myeloid-Neutrophil\|Control / Disease, condition lineage and cell class	DOCK5 SMCHD1 PARD3B IFIT2	2.08e-04	200	65	4	95c41f147a1594d49e73cb56d86d301c3115ce20
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 SMCHD1 ATM NIPBL	2.08e-04	200	65	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	NALCN KLHL13 PDE5A ITGA1	2.08e-04	200	65	4	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KLHL13 GAS6 PDE5A ITGA1	2.08e-04	200	65	4	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Severe / Disease, condition lineage and cell class	NPM1 SMCHD1 CD40LG ATM	2.08e-04	200	65	4	deeed668b129e66156b5f6abe1a07a9bf842a14d
Disease	Congenital Heart Defects	HIF1A ABL1 NIPBL	1.27e-04	44	65	3	C0018798
Disease	alcohol dependence (implicated_via_orthology)	INSRR XRCC5	1.70e-04	9	65	2	DOID:0050741 (implicated_via_orthology)
Disease	pre-eclampsia (is_marker_for)	HIF1A CD40LG CCN3	2.89e-04	58	65	3	DOID:10591 (is_marker_for)
Disease	pre-eclampsia (implicated_via_orthology)	CD40LG PDE5A	3.67e-04	13	65	2	DOID:10591 (implicated_via_orthology)
Disease	colorectal cancer (is_marker_for)	HIF1A ABL1 ATM DSN1	4.06e-04	157	65	4	DOID:9256 (is_marker_for)
Disease	Mood Disorders	HIF1A PROKR2 VPS13A ZNF804A	5.24e-04	168	65	4	C0525045
Disease	CD40 ligand measurement	HIF1A CD40LG	5.62e-04	16	65	2	EFO_0004790
Disease	polycystic kidney disease (biomarker_via_orthology)	HIF1A BECN1	7.98e-04	19	65	2	DOID:0080322 (biomarker_via_orthology)
Disease	Adenocarcinoma of lung (disorder)	NPM1 INSRR ATM XRCC5	1.12e-03	206	65	4	C0152013
Disease	Adenoid Cystic Carcinoma	GAS6 INSRR ATM	1.42e-03	100	65	3	C0010606
Disease	Bone Diseases, Developmental	ABL1 NIPBL	1.62e-03	27	65	2	C0005941
Disease	mean platelet volume	DOCK5 AFAP1 GALK2 SLC35B4 U2SURP ZBTB10 IRAK1BP1 SLFN14	1.75e-03	1020	65	8	EFO_0004584
Disease	spontaneous coronary artery dissection	AFAP1 ITGA1	2.13e-03	31	65	2	EFO_0010820
Disease	reticulocyte measurement	DOCK5 USP9X U2SURP VPS13A PDE5A ITGA1 SLFN14 DDX39A	2.13e-03	1053	65	8	EFO_0010700

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDFVFMKTIQRCNTG	CD40LG	61	P29965
FNQVIIFVKSVQRCM	DDX39A	286	O00148
TDMKQVFTNAEVYNC	BAZ1B	1406	Q9UIG0
SVIQTAKQTFCFMNR	AFAP1	461	Q8N556
AKQTFCFMNRRVISA	AFAP1	466	Q8N556
CFMANVADKSRFTNV	GLCE	256	O94923
LMFCQFQEEQNVRSK	CCDC180	961	Q9P1Z9
LFTMNNSQVSQEICK	ANO3	421	Q9BYT9
YVKNCFRMTDQEAIQ	NPM1	271	P06748
CSRADVFNSKQLTMV	CHM	276	P24386
INFDKFRNCMTATVI	MEIOB	236	Q8N635
TFAQAQDVFRQAMKS	PARD3B	266	Q8TEW8
AEVCITFTEFGKMQN	IRAK1BP1	126	Q5VVH5
QNTQRSFFLRMKCTL	HIF1A	161	Q16665
TSNNSTMQVSFVCQR	BECN1	6	Q14457
NMTVDECFQSRNTVL	TMEM63C	16	Q9P1W3
EVMRFFSDCKIQNGT	HNRNPH2	26	P55795
ATIISFMQVQKCTIF	PDE5A	356	O76074
AVFVIANSCVEMNKA	GALK2	221	Q01415
STQNDFMVICNVAKI	NIPBL	2036	Q6KC79
CVSFNVDVKNSMTFS	ITGA1	26	P56199
NTLFCSKTQQRQMLE	THAP12	226	O43422
QNMCEVNRSFSLKES	ATM	561	Q13315
VQTVDFMRTDNTCVN	KLHL13	296	Q9P2N7
SKENRMSCTVNVLNF	DOCK5	1216	Q9H7D0
MQSVQSTSFCLRKQC	CCN3	1	P48745
RQVFFNMVKETTSNC	DNAH3	2321	Q8TD57
TVKVNTRMQCFSVTE	GAS6	461	Q14393
MDESTQCFQKVSVQL	DSN1	306	Q9H410
FMVKLINQNCDSART	IGFL1	86	Q6UW32
FCVSYVDSIQQMRNK	ABL1	1066	P00519
RTEFQNREFKATMCN	IFIT2	41	P09913
LAARNCMVSQDFTVK	INSRR	1116	P14616
ACNKLSTFTQFSFMV	AGA	316	P20933
CQISVKVTMENTFVN	HEATR1	266	Q9H583
IIVFAFSCKQAEVQM	COLGALT1	266	Q8NBJ5
KQCMAVNFFGTVEVT	HSD17B2	186	P37059
QFNTTNCRSDTVMEK	HMCES	91	Q96FZ2
QTERMLCFSVNGVFK	NXF2	491	Q9GZY0
KTVRQVAQEQFFLMC	USP9X	1326	Q93008
QQTTCQAVTRKTFMQ	SLFN14	636	P0C7P3
IFICTFMSAKQVTSQ	SLC35B4	131	Q969S0
TSVKDMRYCQVSFQD	SMCHD1	1116	A6NHR9
VMRCVTAANQVFFSE	SMG1	436	Q96Q15
QKNMTLSNRCQVFDR	PHF12	326	Q96QT6
SAVCVFTMKDVQRVF	SEMA4B	356	Q9NPR2
NNMEFAQISRVKTFQ	SHPRH	1551	Q149N8
FTIGFQNMVKNTTCD	PKHD1	631	P08F94
VNQFTSVFCLTVMSV	SSTR5	121	P35346
SQTQDIVFQMSRVKC	SNX31	306	Q8N9S9
LQSENFKQRVMTCFR	U2SURP	641	O15042
KQDCSVNMTTFKIRF	VPS13A	871	Q96RL7
QDVRVNQSRCEMKTF	TRIM15	236	Q9C019
NFAQMQSFVRSCALQ	VWA2	546	Q5GFL6
SMINTVCFVTVKNNT	PROKR2	326	Q8NFJ6
IGNIFRVCKTFQMAE	RFC2	296	P35250
SISQKSVFQMFQRCT	RNF168	556	Q8IYW5
CNSVFSMAARQLVIF	ZZEF1	1026	O43149
LQMSEVVQTCRNFIK	ZBTB10	446	Q96DT7
DSIVVNSCQMKFQLR	GTF3C1	1666	Q12789
MVVNTACKENTSQYF	SMC5	1036	Q8IY18
CKSSQVQRRFFMGNQ	XRCC5	346	P13010
AFKNNTQFCTCISME	XKR9	246	Q5GH70
MFKSTTVTVRENCNE	ZNF804A	136	Q7Z570
QMNDVVNFCKTYIRS	ZBTB8B	106	Q8NAP8
SFMKQFIDRQQQDTC	NALCN	661	Q8IZF0