Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10 ALG10B	1.35e-05	2	74	2	GO:0106073
GeneOntologyCellularComponent	inhibitory synapse	ERBB4 IGSF9B RIMS2	1.78e-04	31	74	3	GO:0060077
GeneOntologyCellularComponent	GABA-ergic synapse	ERBB4 HAP1 CAMK4 IGSF9B RIMS2	2.91e-04	164	74	5	GO:0098982
Domain	Alg10	ALG10 ALG10B	1.55e-05	2	74	2	IPR016900
Domain	DIE2_ALG10	ALG10 ALG10B	1.55e-05	2	74	2	PF04922
Domain	Growth_fac_rcpt_	ERBB4 UMODL1 MATN4 TNXB GPR179	3.86e-04	156	74	5	IPR009030
Domain	2OG-FeII_Oxy_3	P3H1 P4HA3	8.32e-04	11	74	2	PF13640
Domain	-	DOK1 ADAP1 FGD2 CYTH3 MTM1 PLCL2 RGS3	9.01e-04	391	74	7	2.30.29.30
Domain	PH_dom-like	DOK1 ADAP1 FGD2 CYTH3 MTM1 PLCL2 RGS3	1.48e-03	426	74	7	IPR011993
Domain	P4Hc	P3H1 P4HA3	1.79e-03	16	74	2	SM00702
Domain	Pro_4_hyd_alph	P3H1 P4HA3	1.79e-03	16	74	2	IPR006620
Domain	TPR-like_helical_dom	FBXO9 P3H1 TTC14 P4HA3 CRTAP	2.32e-03	233	74	5	IPR011990
Domain	EGF	SNED1 UMODL1 MATN4 TNXB GPR179	2.41e-03	235	74	5	SM00181
Domain	2OG-FeII_Oxy	P3H1 P4HA3	2.54e-03	19	74	2	PF03171
Domain	FE2OG_OXY	P3H1 P4HA3	3.10e-03	21	74	2	PS51471
Domain	Oxoglu/Fe-dep_dioxygenase	P3H1 P4HA3	3.71e-03	23	74	2	IPR005123
Domain	fn3	SNED1 UMODL1 IGSF9B TNXB	3.92e-03	162	74	4	PF00041
Domain	TPR_REGION	FBXO9 P3H1 TTC14 P4HA3	4.18e-03	165	74	4	PS50293
Domain	TPR	FBXO9 P3H1 TTC14 P4HA3	4.18e-03	165	74	4	PS50005
Pubmed	A "double adaptor" method for improved shotgun library construction.	DMTF1 DOK1 KIAA0930 ERBB4 POLR2B PRKAR1A CPD RIMS2 RGS3 ADD2	3.86e-07	574	74	10	8619474
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	DMTF1 RHBDL2 PA2G4 CSNK1G3 POLR2B PLCL2 TTC14 SAFB2 GCNT2 MTO1 TASOR ZMAT1	2.93e-06	1084	74	12	11544199
Pubmed	Large-scale concatenation cDNA sequencing.	DMTF1 DOK1 KIAA0930 ERBB4 POLR2B PRKAR1A RIMS2 RGS3 ADD2	3.34e-06	568	74	9	9110174
Pubmed	Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex.	P3H1 CRTAP	4.47e-06	2	74	2	19846465
Pubmed	Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta.	P3H1 CRTAP	4.47e-06	2	74	2	19862557
Pubmed	Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.	P3H1 CRTAP	4.47e-06	2	74	2	24465224
Pubmed	CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta.	P3H1 CRTAP	4.47e-06	2	74	2	18566967
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CACNA1B PA2G4 SAFB2 PRKAR1A RIMS2 ADD2	1.02e-05	231	74	6	16452087
Pubmed	Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.	P3H1 CRTAP	1.34e-05	3	74	2	20089953
Pubmed	An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.	P3H1 CRTAP	1.34e-05	3	74	2	24043621
Pubmed	Osteogenesis imperfecta caused by COL1A1, CRTAP and LEPRE1 mutations. Report of 2cases.	P3H1 CRTAP	1.34e-05	3	74	2	30389107
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10 ALG10B	1.34e-05	3	74	2	24303013
Pubmed	Mutational characterization of the P3H1/CRTAP/CypB complex in recessive osteogenesis imperfecta.	P3H1 CRTAP	1.34e-05	3	74	2	26634552
Pubmed	Dok1 encoding p62(dok) maps to mouse chromosome 6 and human chromosome 2 in a region of translocation in chronic lymphocytic leukemia.	DOK1 ADD2	1.34e-05	3	74	2	9790776
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10 ALG10B	2.67e-05	4	74	2	14525949
Pubmed	Mutation and polymorphism spectrum in osteogenesis imperfecta type II: implications for genotype-phenotype relationships.	P3H1 CRTAP	2.67e-05	4	74	2	18996919
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B RIMS2	9.31e-05	7	74	2	35176221
Pubmed	High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.	DOK1 ADD2	1.99e-04	10	74	2	9806835
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	PA2G4 CAMK4 POLR2B SAFB2 P4HA3 RIMS2 TASOR STAG3	2.01e-04	754	74	8	35906200
Pubmed	Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.	FGD2 MLC1 MOV10L1 ADD2	3.77e-04	159	74	4	24927181
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CTDSPL2 CEBPZ P3H1 MTM1 POLR2B PLCL2 CPD AJUBA ADD2	3.81e-04	1049	74	9	27880917
Pubmed	The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.	CEBPZ PA2G4 SAFB2	3.84e-04	66	74	3	32051553
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	CTDSPL2 CEBPZ CHD8 CPD TASOR	4.11e-04	293	74	5	31741433
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	ADAP1 CSNK1G3	4.61e-04	15	74	2	15003508
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	CACNA1B PRKAR1A CHGB RGS3	7.51e-04	191	74	4	20195357
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	CACNA1B CHGB RIMS2	8.06e-04	85	74	3	23055939
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	INTS6 P3H1 CSNK1G3 NMRAL1 MCOLN1 ADD2 SNX13	8.50e-04	719	74	7	35337019
Pubmed	Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.	IRF5 TNXB	9.14e-04	21	74	2	21408207
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10 ALG10B	1.10e-03	23	74	2	12955145
Pubmed	The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.	INTS6 POLR2B	1.30e-03	25	74	2	34004147
Pubmed	Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.	PLCL2 IRF5	1.40e-03	26	74	2	21399635
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PLCL2 IGSF9B TASOR	1.44e-03	104	74	3	10470851
Pubmed	Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.	CACNA1B CAMK4	1.63e-03	28	74	2	10087302
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	PA2G4 POLR2B PRKAR1A	1.74e-03	111	74	3	32683582
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	INTS6 POLR2B SAFB2 TASOR	1.85e-03	244	74	4	29884807
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	SAFB2 PRKAR1A MCOLN1 ADD2	1.91e-03	246	74	4	15345747
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	PA2G4 P3H1 TENT5C CPD	1.96e-03	248	74	4	32963011
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	FOXRED2 NDUFS7 P3H1 POLR2B CPD CRTAP	1.97e-03	613	74	6	22268729
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	CACNA1B RGS3	2.13e-03	32	74	2	19320717
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10 ALG10B	6.90e-06	2	48	2	448
Coexpression	GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN	ACSL1 FZD7 PUS3 FBXO9 POLR2B MTO1	2.08e-05	198	74	6	M5782
Coexpression	GSE14308_TH1_VS_INDUCED_TREG_UP	CACNA1B GALNS CTDSPL2 TTC14 KATNA1 STAG3	2.20e-05	200	74	6	M3378
CoexpressionAtlas	Myeloid Cells, Mo.6C-II-.BM, B220neg CD3neg CD115+ Ly-6C/Glo CD43+, Bone marrow, avg-3	DOK1 FZD7 KIAA0930 ADAP1 IP6K3 FGD2 CYTH3 IRF5 CPD GCNT2	1.51e-06	409	74	10	GSM854332_500
CoexpressionAtlas	DevelopingGonad_P2_testes_emap-30171_k-means-cluster#1_top-relative-expression-ranked_1000	MOV10L1 DMRTA1 CHD8 STAG3	1.25e-05	41	74	4	gudmap_developingGonad_P2_testes_1000_k1
ToppCell	RA-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	ESRP2 ERBB4 MLC1 MATN4 CHGB	3.08e-06	135	74	5	6121b1d30d05b7d476661b932f51191da09dfeeb
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAP1 CHGB SHISA6 GPR179 ADD2	1.25e-05	180	74	5	0677bf4a5177d9cbc6716195bd966eeae8de2f31
ToppCell	(2)_5-FU-(4)_COL2.3+_osteoblasts\|World / Stress and Cell class	RHBDL2 P3H1 TENT5C MATN4 CRTAP	1.39e-05	184	74	5	684d05340a3dfb8aa08b881516a37f9627a10448
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ACSL1 CACNA1B TENT5C CHGB RIMS2	1.62e-05	190	74	5	b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1B HAP1 PLCL2 CHGB ADD2	1.66e-05	191	74	5	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1B HAP1 PLCL2 CHGB ADD2	1.66e-05	191	74	5	73dae4cdea86aec62393ad7303dc7375a6b3fc86
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10 MTO1 ALG10B	2.66e-07	6	71	3	DOID:0050563 (implicated_via_orthology)
Disease	Long Qt Syndrome 2	ALG10 ALG10B	1.71e-05	3	71	2	C3150943
Disease	3b-hydroxy-5-cholenoic acid measurement	ADCK5 SLC27A5	3.41e-05	4	71	2	EFO_0800348
Disease	Osteogenesis imperfecta, dominant perinatal lethal	P3H1 CRTAP	5.68e-05	5	71	2	C0268358
Disease	Lobstein Disease	P3H1 CRTAP	5.68e-05	5	71	2	C0023931
Disease	Chronic schizophrenia	MLC1 CHGB	2.03e-04	9	71	2	C0221765
Disease	Osteogenesis imperfecta type III (disorder)	P3H1 CRTAP	3.10e-04	11	71	2	C0268362
Disease	Osteogenesis Imperfecta	P3H1 CRTAP	4.38e-04	13	71	2	C0029434
Disease	hair colour measurement	FZD7 KIAA0930 GALNS NMRAL1 GCNT2 RGS3 SNX13	6.93e-04	615	71	7	EFO_0007822
Disease	S-adenosylhomocysteine measurement	CACNA1B KATNA1	7.58e-04	17	71	2	EFO_0010531
Disease	unipolar depression, alcohol dependence	RHBDL2 IGSF9B STAG3	8.92e-04	78	71	3	EFO_0003761, MONDO_0007079
Disease	Osteogenesis imperfecta	P3H1 CRTAP	1.16e-03	21	71	2	cv:C0029434
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 MTM1	1.52e-03	24	71	2	DOID:10595 (implicated_via_orthology)
Disease	TEMPS-A questionnaire	ERBB4 SHISA6	1.65e-03	25	71	2	EFO_0004783

Protein segments in the cluster

Peptide	Gene	Start	Entry
RDFLELFFRMVRGSL	UMODL1	816	Q5DID0
AAEFSRMARDPQRYL	ERBB4	971	Q15303
EFAVDPRFLAYMEDR	CHD8	2346	Q9HCK8
VRLRPFFREFLERMS	CTDSPL2	326	Q05D32
ARARMREPEAREDYF	AJUBA	321	Q96IF1
LFRYFRMPELVDFRQ	ACSL1	6	P33121
APVDRYFLMAKRAVR	ADCK5	496	Q3MIX3
RLMYFKDPLDAFARG	ADAP1	281	O75689
AFSRALREPYMDEIF	ALG10B	26	Q5I7T1
ALYSEMDPEERLRFA	CACNA1B	786	Q00975
PLFAVYRRVLRMYDD	DMTF1	206	Q9Y222
LDESRPLFERYRAMF	DOHH	166	Q9BU89
PLFERYRAMFALRNA	DOHH	171	Q9BU89
RIFGLMEKDSYPRFL	RGS3	1166	P49796
RDPASRGDRYMLVTF	INTS6	41	Q9UL03
RRIMESYFRLDTPLY	P3H1	546	Q32P28
REFLLYSPDNKRMAR	P4HA3	251	Q7Z4N8
PEEEDLRRRLKYFFM	MCOLN1	36	Q9GZU1
RRFDAMPFTLRAFED	PA2G4	271	Q9UQ80
FPLRAFSRREDMERA	MATN4	86	O95460
SFLERLMSRPAYQRD	MOV10L1	936	Q9BXT6
DLANMFRFYALRPDR	NMRAL1	256	Q9HBL8
FRFYALRPDRDIELT	NMRAL1	261	Q9HBL8
GRSFMRYLAEFPEAL	GPR179	716	Q6PRD1
FYDERGDQFMFRRIL	CAMK4	241	Q16566
EPYRMFTSRVEFRLS	MTO1	486	Q9Y2Z2
DFGTFERLFRAIYMP	GCNT2	106	Q8N0V5
YDMRRLSEILAFPRA	KIAA1109	4256	Q2LD37
PRQDDMLFYVRRKLA	KIAA0930	46	Q6ICG6
KSRDFRLIYDGPRDM	IRF5	96	Q13568
RAYFPDARDMVRYLG	FOXRED2	116	Q8IWF2
REQRFYESLPLAMKR	IP6K3	46	Q96PC2
PEMATYLRYVRRLDF	CSNK1G3	281	Q9Y6M4
FIYSPVHRREFRERM	RIMS2	876	Q9UQ26
GLMYFKEEERRFARL	FZD7	241	O75084
RLMDRPIFYYRGDTL	GALNS	376	P34059
PYFRAMFTGELAESR	KLHL20	91	Q9Y2M5
LRRYGRDKVMFSFEA	DOK1	206	Q99704
EMFLERPRVRFDGVY	FBXO9	256	Q9UK97
YSFRSFPRDELMPLE	CRTAP	31	O75718
EMPRGDTSSLRYDFR	HAP1	511	P54257
FRPALDYAFSGMIRD	DMRTA1	466	Q5VZB9
FPDMEIFLRRFANEY	CPD	506	O75976
SRDPFYDMLATRKRR	CYTH3	381	O43739
FRRNDPMERYLFLFN	FGD2	331	Q7Z6J4
PMAFLREYFERLEKE	PRKAR1A	46	P10644
RLLFEMARFYSPATI	KATNA1	291	O75449
PRAYFMSDTREEKRF	CHGB	426	P05060
TLMRFLDRFVYRNPK	CEBPZ	751	Q03701
AFLFEYDTPRMVLVR	P2RX1	11	P51575
ELMLRDERFYPSFRQ	SNX13	491	Q9Y5W8
RYFFPRADLDIVTMD	PUS3	196	Q9BZE2
LDMGFALYRRFFVPE	RHBDL2	226	Q9NX52
YVLRPAIMREEVSFF	PLCL2	726	Q9UPR0
TRSMEYLRFRELPAG	POLR2B	761	P30876
EADEYYMRRRHLPDL	SHISA6	321	Q6ZSJ9
LPDMFFSFYDLRREF	ESRP2	151	Q9H6T0
YDMDRFGVVFRASPR	NDUFS7	101	O75251
LERYMCSRFFIDFPD	TENT5C	266	Q5VWP2
VYYREATDPAMLRRA	SNED1	116	Q8TER0
REFIMFPYDSRLDDK	TASOR	571	Q9UK61
FDRFSEDDPEYMRLR	ADD2	21	P35612
AFSRALREPYMDEIF	ALG10	26	Q5BKT4
RDMFEILTRYAFPLA	MTM1	131	Q13496
LPAFIEMRDLARRFA	STAG3	951	Q9UJ98
VLAMDREGFLYFRDR	SLC27A5	536	Q9Y2P5
SFPIDRYIMEFRVAE	IGSF9B	641	Q9UPX0
FDTFMVQYRDRDGRP	TNXB	1186	P22105
KQRYRMIDFLRFRPE	MRPL2	101	Q5T653
PSMDRRELFFRDIER	TTC14	111	Q96N46
KRVAMEDRYRADFPR	SAFB2	746	Q14151
AMREPSLLRFYVSRE	USP20	701	Q9Y2K6
GFLLREEEPEYMDFR	ZSWIM2	41	Q8NEG5
DFMYEGRLDLRSLPV	ZBTB42	81	B2RXF5
YKEAMVVSSFRRFPR	TEX36	131	Q5VZQ5
RMFEQRLPFETFRTY	ZMAT1	266	Q5H9K5
FREELAYDRMPTLER	MLC1	6	Q15049