Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH3 DNAH10 MYO6 KIF26A KIF26B DNAH9

2.79e-06118676GO:0003774
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH3 DNAH10 KIF26A KIF26B DNAH9

3.74e-0670675GO:0003777
GeneOntologyMolecularFunctioncalcium ion binding

ESYT3 THBS2 MYL2 CLXN MACF1 CASQ2 PLCB2 ADGRV1 MYL10 PKDREJ RYR1 ATP5F1B

6.40e-067496712GO:0005509
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH3 DNAH10 DNAH9 HTT

7.03e-0637674GO:0045505
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH3 DNAH10 DNAH9

2.84e-0518673GO:0008569
GeneOntologyMolecularFunctionenzyme regulator activity

STARD13 USP14 CPAMD8 SERPINA1 RAP1GAP GCLM PPP1R3B TRMT112 ATG13 ARHGAP12 EIF2B2 GCGR DENND1C ADGRV1 MCF2L

5.62e-0514186715GO:0030234
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH3 DNAH10 DNAH9

1.11e-0428673GO:0051959
GeneOntologyMolecularFunctionATP-dependent activity

ATP5PF DNAH3 DNAH10 MYO6 KIF26A KIF26B MACF1 DNAH9 ATP5F1B

2.02e-04614679GO:0140657
GeneOntologyMolecularFunctionphosphatidylinositol binding

ESYT3 STAM2 CGAS DENND1C STAM MCF2L

6.65e-04316676GO:0035091
GeneOntologyMolecularFunctionATP hydrolysis activity

ATP5PF DNAH3 DNAH10 KIF26A MACF1 DNAH9 ATP5F1B

6.78e-04441677GO:0016887
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

STARD13 RAP1GAP ARHGAP12 EIF2B2 GCGR DENND1C MCF2L

1.52e-03507677GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

STARD13 RAP1GAP ARHGAP12 EIF2B2 GCGR DENND1C MCF2L

1.52e-03507677GO:0030695
GeneOntologyMolecularFunctionlipid binding

STARD13 ESYT3 TARDBP STAM2 CGAS PLCB2 DENND1C STAM PPARG MCF2L

1.60e-039886710GO:0008289
GeneOntologyMolecularFunctionproton-transporting ATP synthase activity, rotational mechanism

ATP5PF ATP5F1B

1.64e-0318672GO:0046933
GeneOntologyCellularComponentESCRT-0 complex

STAM2 STAM

3.03e-053672GO:0033565
GeneOntologyCellularComponentaxoneme

SPATA7 DNAH3 CLXN DNAH10 DNAH9 AK8

5.29e-05207676GO:0005930
GeneOntologyCellularComponentciliary plasm

SPATA7 DNAH3 CLXN DNAH10 DNAH9 AK8

5.44e-05208676GO:0097014
GeneOntologyCellularComponentaxonemal dynein complex

DNAH3 DNAH10 DNAH9

6.88e-0525673GO:0005858
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

SPATA7 DNAH3 CLXN DNAH10 DNAH9 AK8 HTT

6.89e-05317677GO:0032838
GeneOntologyCellularComponentcytoplasmic region

SPATA7 DNAH3 CLXN DNAH10 DNAH9 AK8 HTT

1.52e-04360677GO:0099568
GeneOntologyCellularComponentjunctional membrane complex

CASQ2 RYR1

3.59e-049672GO:0030314
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

CASQ2 RYR1

4.48e-0410672GO:0014701
GeneOntologyCellularComponentinner dynein arm

DNAH3 DNAH10

4.48e-0410672GO:0036156
GeneOntologyCellularComponentdynein complex

DNAH3 DNAH10 DNAH9

6.94e-0454673GO:0030286
GeneOntologyCellularComponentmotile cilium

DNAH3 CFAP300 CLXN DNAH10 DNAH9 AK8

9.60e-04355676GO:0031514
GeneOntologyCellularComponent9+2 motile cilium

DNAH3 CLXN DNAH10 DNAH9 AK8

9.98e-04238675GO:0097729
MousePhenoparalysis

USP14 TARDBP CLCN1 VPS54 RYR1 HTT

8.54e-06119576MP:0000753
MousePhenoincreased susceptibility to malignant hyperthermia

RYR1 HTT

1.63e-052572MP:0020214
MousePhenopremature death

USP14 TARDBP THBS2 MYL2 CLCN1 GNE KIF26A VPS54 PRKDC STAM PPARG SIRT1 RYR1 HTT

6.09e-0510515714MP:0002083
DomainDynein_heavy_chain_D4_dom

DNAH3 DNAH10 DNAH9

1.56e-0514673IPR024317
DomainDynein_HC_stalk

DNAH3 DNAH10 DNAH9

1.56e-0514673IPR024743
DomainDynein_heavy_dom-2

DNAH3 DNAH10 DNAH9

1.56e-0514673IPR013602
DomainDHC_N2

DNAH3 DNAH10 DNAH9

1.56e-0514673PF08393
DomainMT

DNAH3 DNAH10 DNAH9

1.56e-0514673PF12777
DomainAAA_8

DNAH3 DNAH10 DNAH9

1.56e-0514673PF12780
DomainATPase_dyneun-rel_AAA

DNAH3 DNAH10 DNAH9

1.56e-0514673IPR011704
DomainAAA_5

DNAH3 DNAH10 DNAH9

1.56e-0514673PF07728
DomainDHC_fam

DNAH3 DNAH10 DNAH9

1.95e-0515673IPR026983
DomainDynein_heavy_dom

DNAH3 DNAH10 DNAH9

1.95e-0515673IPR004273
DomainDynein_heavy

DNAH3 DNAH10 DNAH9

1.95e-0515673PF03028
Domain-

MYL2 CLXN MACF1 PLCB2 MYL10 RYR1

3.44e-042616761.10.238.10
DomainDHC_N1

DNAH10 DNAH9

3.50e-048672PF08385
DomainDynein_heavy_dom-1

DNAH10 DNAH9

3.50e-048672IPR013594
DomainVHS

STAM2 STAM

4.49e-049672PF00790
DomainVHS

STAM2 STAM

4.49e-049672PS50179
DomainVHS

STAM2 STAM

4.49e-049672SM00288
DomainVHS_dom

STAM2 STAM

4.49e-049672IPR002014
DomainITAM_1

STAM2 STAM

5.60e-0410672PS51055
DomainPhos_immunorcpt_sig_ITAM

STAM2 STAM

5.60e-0410672IPR003110
DomainEF-hand-dom_pair

MYL2 CLXN MACF1 PLCB2 MYL10 RYR1

5.68e-04287676IPR011992
DomainHEAT

SCYL2 PRKDC HTT

6.80e-0448673PF02985
DomainEF-hand_6

MYL2 MYL10

9.64e-0413672PF13405
DomainSH3

STAM2 ARHGAP12 MACF1 STAM MCF2L

1.07e-03216675PS50002
DomainSH3_domain

STAM2 ARHGAP12 MACF1 STAM MCF2L

1.16e-03220675IPR001452
DomainHEAT

SCYL2 PRKDC HTT

1.18e-0358673IPR000357
DomainEF_hand_dom

MYL2 CLXN MACF1 MYL10 RYR1

1.46e-03232675IPR002048
DomainAAA+_ATPase

DNAH3 DNAH10 DNAH9 ATP5F1B

1.78e-03144674IPR003593
DomainAAA

DNAH3 DNAH10 DNAH9 ATP5F1B

1.78e-03144674SM00382
DomainUIM

STAM2 STAM

1.87e-0318672PF02809
DomainHEAT_REPEAT

SCYL2 PRKDC HTT

2.03e-0370673PS50077
DomainEFh

MYL2 CLXN MACF1 MYL10

2.50e-03158674SM00054
DomainUIM

STAM2 STAM

2.55e-0321672SM00726
DomainPentatricopeptide_repeat

PRKDC HTT

3.06e-0323672IPR002885
DomainSpectrin

MACF1 MCF2L

3.06e-0323672PF00435
DomainP-loop_NTPase

DNAH3 DNAH10 MYO6 KIF26A KIF26B DNAH9 AK8 ATP5F1B NLRP13

3.16e-03848679IPR027417
DomainUIM

STAM2 STAM

3.33e-0324672PS50330
DomainUIM_dom

STAM2 STAM

3.61e-0325672IPR003903
DomainEF_Hand_1_Ca_BS

MYL2 CLXN MACF1 MYL10

3.61e-03175674IPR018247
Domain-

STAM2 STAM

3.90e-03266721.25.40.90
DomainENTH_VHS

STAM2 STAM

4.84e-0329672IPR008942
DomainSpectrin_repeat

MACF1 MCF2L

4.84e-0329672IPR002017
DomainSpectrin/alpha-actinin

MACF1 MCF2L

5.87e-0332672IPR018159
DomainSPEC

MACF1 MCF2L

5.87e-0332672SM00150
DomainEF_HAND_1

MYL2 CLXN MACF1 MYL10

6.20e-03204674PS00018
DomainGPS

ADGRV1 PKDREJ

6.60e-0334672SM00303
PathwayKEGG_HUNTINGTONS_DISEASE

ATP5PF DNAH3 POLR2E PLCB2 PPARG HTT ATP5F1B

7.24e-06182567M13486
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH10 DNAH9 HTT

2.95e-0545564M47670
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT

DNAH3 DNAH10 DNAH9

1.62e-0427563M47755
Pubmed

Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.

DNAH3 DNAH10 DNAH9

2.73e-08467311175280
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

SCYL2 STAM2 PTPN13 MYO6 GCLM ARHGAP12 MACF1 PRKDC STAM ATP5F1B

1.00e-06708671039231216
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

USP14 STAM2 GNE GCLM TRMT112 POLR2E EIF2B2 MACF1 COPS3 PRKDC SIRT1 HTT ATP5F1B

3.51e-061455671322863883
Pubmed

Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

CLCN1 VPS54

3.66e-0626728008830
Pubmed

Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle.

CLCN1 RYR1

3.66e-06267221078869
Pubmed

SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis.

PPARG SIRT1

3.66e-06267220033348
Pubmed

Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells.

PPARG SIRT1

3.66e-06267221948987
Pubmed

Resveratrol Regulates the Quiescence-Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio.

PPARG SIRT1

3.66e-06267225833683
Pubmed

DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.

CGAS PRKDC

3.66e-06267236574362
Pubmed

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.

CGAS PRKDC

3.66e-06267233273464
Pubmed

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.

TARDBP SIRT1

3.66e-06267235264561
Pubmed

Sirt1 inhibits gouty arthritis via activating PPARγ.

PPARG SIRT1

3.66e-06267231367941
Pubmed

Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.

PRKDC PPARG

3.66e-06267217312139
Pubmed

The Function of PPARγ/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.

PPARG SIRT1

3.66e-06267231366866
Pubmed

Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease.

TARDBP HTT

3.66e-06267219018245
Pubmed

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease.

CGAS HTT

3.66e-06267232581130
Pubmed

Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease.

PPARG HTT

3.66e-06267218640979
Pubmed

Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases.

PPARG SIRT1

3.66e-06267223636469
Pubmed

From the Cover: l-Carnitine via PPARγ- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate.

PPARG SIRT1

3.66e-06267228973641
Pubmed

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.

STAM2 STAM

3.66e-06267212446783
Pubmed

Deubiquitylation and stabilization of Acf7 by ubiquitin carboxylterminal hydrolase 14 (USP14) is critical for NSCLC migration.

USP14 MACF1

3.66e-06267233737492
Pubmed

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

PTPN5 HTT

3.66e-06267221632937
Pubmed

Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor.

ATP5PF ATP5F1B

3.66e-06267216230521
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

STARD13 USP14 TARDBP GNE MYO6 SHCBP1 POLR2E CGAS MACF1 COPS3 PRKDC ATP5F1B

9.47e-061353671229467282
Pubmed

Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.

CASQ2 RYR1

1.10e-05367224143248
Pubmed

TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells.

PPARG SIRT1

1.10e-05367229175458
Pubmed

Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin.

CASQ2 RYR1

1.10e-05367214638677
Pubmed

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.

TARDBP CGAS

1.10e-05367233031745
Pubmed

SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence.

PPARG SIRT1

1.10e-05367220660480
Pubmed

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.

STAM2 STAM

1.10e-05367213679051
Pubmed

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.

PPARG SIRT1

1.10e-05367222863012
Pubmed

Hybrid structural model of the complete human ESCRT-0 complex.

STAM2 STAM

1.10e-05367219278655
Pubmed

DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro.

TARDBP PRKDC

1.10e-05367228832631
Pubmed

Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.

CLCN1 RYR1

1.10e-05367217158949
Pubmed

Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.

PPARG SIRT1

1.10e-05367217954559
Pubmed

Association with Hrs is required for the early endosomal localization, stability, and function of STAM.

STAM2 STAM

1.10e-05367215113837
Pubmed

Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice.

PPARG SIRT1

1.10e-05367225948680
Pubmed

Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}.

MYL2 PPARG

1.10e-05367220884641
Pubmed

Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.

CGAS PRKDC

1.10e-05367235460603
Pubmed

Association of triadin with the ryanodine receptor and calsequestrin in the lumen of the sarcoplasmic reticulum.

CASQ2 RYR1

1.10e-0536727721813
Pubmed

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation.

PPARG SIRT1

1.10e-05367232987623
Pubmed

MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis.

SCAMP3 PPARG

1.10e-05367231554889
Pubmed

Differential roles of cardiomyocyte and macrophage peroxisome proliferator-activated receptor gamma in cardiac fibrosis.

MYL2 PPARG

1.10e-05367218511847
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SCYL2 USP14 TARDBP STAM2 PTPN13 MYO6 MACF1 PRKDC STAM ATP5F1B

1.15e-05934671033916271
Pubmed

Genetic variation in healthy oldest-old.

PPARG SIRT1 TRDMT1

1.34e-052467319680556
Pubmed

Functional proteomics mapping of a human signaling pathway.

SCYL2 STARD13 STAM2 MYO6 PPP1R3B EXPH5 MACF1 STAM

1.79e-0559167815231748
Pubmed

The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.

STAM2 STAM

2.19e-05467226601948
Pubmed

Enhanced mitochondrial biogenesis ameliorates disease phenotype in a full-length mouse model of Huntington's disease.

PPARG HTT

2.19e-05467227008868
Pubmed

Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways.

MYO6 ARHGAP12

2.19e-05467224942165
Pubmed

Neurodegeneration-associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells.

TARDBP SIRT1

2.19e-05467222584570
Pubmed

GAPDH mediates nitrosylation of nuclear proteins.

PRKDC SIRT1

2.19e-05467220972425
Pubmed

Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties.

CLCN1 VPS54

2.19e-0546726589628
Pubmed

Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.

PPARG SIRT1

2.19e-05467223663737
Pubmed

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.

STAM2 STAM

2.19e-05467212551915
Pubmed

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.

PPARG SIRT1

2.19e-05467229233982
Pubmed

Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1α.

USP14 HTT

2.19e-05467224951540
Pubmed

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.

STAM2 STAM

2.19e-05467212972556
Pubmed

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway.

SIRT1 HTT

2.19e-05467222179316
Pubmed

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.

USP14 CGAS

2.19e-05467227666593
Pubmed

Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor γ in MC3T3-E1 cells.

PPARG SIRT1

2.19e-05467227378422
Pubmed

Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: a probable linkage between obesity and coronary arterial disease.

PPARG SIRT1

2.19e-05467227072559
Pubmed

Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1.

PPARG SIRT1

2.19e-05467225275593
Pubmed

STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.

STAM2 STAM

2.19e-05467219054391
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

STARD13 USP14 TARDBP MYL2 MACF1 COPS3 PRKDC RYR1 ATP5F1B

2.40e-0580767930575818
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

STARD13 CPAMD8 SERPINA1 RAP1GAP CLXN GNE EXPH5 SHCBP1 COPS3 DCT RYR1

3.42e-051293671115342556
Pubmed

Structure and ubiquitin binding of the ubiquitin-interacting motif.

STAM2 STAM

3.64e-05567212750381
Pubmed

Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.

STAM2 STAM

3.64e-05567217235283
Pubmed

Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.

MYL2 PPARG

3.64e-05567219490906
Pubmed

PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.

STAM2 STAM

3.64e-05567220504764
Pubmed

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity.

CGAS PRKDC

3.64e-05567231665636
Pubmed

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

PPARG SIRT1

3.64e-05567215175761
Pubmed

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

GCGR PPARG

3.64e-05567237848446
Pubmed

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.

MYO6 HTT

3.64e-05567215837803
Pubmed

Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.

STAM2 STAM

3.64e-05567222275353
Pubmed

Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex.

STAM2 STAM

3.64e-05567220736164
Pubmed

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.

STAM2 STAM

3.64e-05567211687594
Pubmed

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.

ATP5PF STAM2 MYO6 STAM

4.13e-059967429676259
Pubmed

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.

STAM2 STAM

5.46e-05667210982817
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

GCGR PRKDC

5.46e-05667228591638
Pubmed

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

TARDBP HTT

7.63e-05767224882209
Pubmed

Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility.

CGAS PRKDC

7.63e-05767234015257
Pubmed

AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.

STAM2 STAM

7.63e-05767220159979
Pubmed

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice.

PPARG SIRT1

7.63e-05767219653817
Pubmed

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.

SIRT1 HTT

7.63e-05767222956852
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SCYL2 USP14 TARDBP STAM2 PTPN13 PRKDC HTT

9.02e-0554967738280479
Pubmed

STAM2, a new member of the STAM family, binding to the Janus kinases.

STAM2 STAM

1.02e-04867210899310
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

CASQ2 RYR1

1.02e-04867211784029
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

PTPN5 MYO6 EXPH5 POLR2E PRKDC ATP5F1B TRDMT1

1.18e-0457367728330616
Pubmed

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

SCYL2 ATP5PF SHCBP1 COPS3 PRKDC ATP5F1B

1.25e-0440167625852190
Pubmed

Molecular characterization of ENU mouse mutagenesis and archives.

TARDBP HTT

1.30e-04967216139793
Pubmed

Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.

TARDBP HTT

1.30e-04967235701899
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

SCYL2 TARDBP STAM2 STAM RYR1

1.51e-0426167533277362
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

PTPN13 MYO6 EXPH5 MACF1 STAM

1.57e-0426367534702444
Pubmed

Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City.

PPARG SIRT1

1.63e-041067220503258
Pubmed

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.

MYL2 CASQ2

1.63e-041067214963485
Pubmed

A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.

MYO6 ADGRV1

1.63e-041067217329413
Pubmed

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice.

THBS2 ANPEP DNAH9

1.76e-045667330104731
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

SCYL2 TARDBP MYO6 SCAMP3 COPS3 PRKDC ATP5F1B

1.78e-0461367722268729
Pubmed

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.

PRKDC PPARG

1.99e-041167235449157
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

STAM2 STAM

1.99e-041167229604273
InteractionGJA1 interactions

SCYL2 STAM2 PTPN13 MYO6 CGAS MACF1 SCAMP3 VPS54 STAM HTT ATP5F1B

3.20e-065836711int:GJA1
GeneFamilyDyneins, axonemal

DNAH3 DNAH10 DNAH9

1.24e-0517493536
GeneFamilyESCRT-0

STAM2 STAM

2.15e-0534921115
GeneFamilyMyosin light chains|EF-hand domain containing

MYL2 MYL10

6.41e-0414492657
GeneFamilyProtein tyrosine phosphatases, non-receptor type

PTPN5 PTPN13

1.07e-0318492812
GeneFamilyF-type ATPases|Mitochondrial complex V: ATP synthase subunits

ATP5PF ATP5F1B

1.07e-0318492416
GeneFamilyF-type ATPases|Mitochondrial complex V: ATP synthase subunits

ATP5PF ATP5F1B

1.19e-0319492644
GeneFamilyEF-hand domain containing

MYL2 CLXN MACF1 MYL10

2.90e-03219494863
GeneFamilyPhospholipases

PLB1 PLCB2

5.78e-0342492467
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF26A KIF26B

6.90e-0346492622
GeneFamilyRho GTPase activating proteins|BCH domain containing

STARD13 ARHGAP12

8.11e-0350492721
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R3B VPS54 RYR1

1.30e-02181493694
CoexpressionGSE21063_3H_VS_16H_ANTI_IGM_STIM_BCELL_UP

TARDBP SLC9A9 CFAP300 ADGRV1 PPARG SIRT1

1.24e-05200676M8264
CoexpressionGAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS

CFAP300 CLXN DNAH10 TMEM151B MACF1 PLCB2 DNAH9 AK8

2.20e-05459678M39136
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9 AK8

4.09e-07189676c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9 AK8

4.49e-07192676d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellIPF-Epithelial-Ciliated|IPF / Disease state, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9 AK8

4.49e-07192676354adc1354bf596fbc60dd45c0169688e6f45165
ToppCellControl-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9 AK8

4.77e-07194676958e648138676d46698090b4046cb484083ae449
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 EXPH5 DNAH9

5.22e-0719767618fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH3 SERPINA1 ANPEP DNAH10 DNAH9 AK8

5.37e-07198676e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

DNAH3 SERPINA1 ANPEP DNAH10 DNAH9 AK8

5.37e-07198676e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH3 SERPINA1 CFAP300 ANPEP DNAH10 DNAH9

5.70e-07200676da12821e8a0657869ca0f75d351cce2d7605a505
ToppCelldistal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH3 CFAP300 CLXN PKDREJ DNAH9 AK8

5.70e-07200676f5f5a8b0e4d802d95dc42646dd5e7d7daaad72b4
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DNAH3 SERPINA1 CFAP300 ANPEP DNAH10 DNAH9

5.70e-0720067672c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC9A9 CLXN EXPH5 PPARG RYR1

2.41e-06142675d08e1880425d285c4433014fe0242ac7ff7734af
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

2.95e-06148675d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

2.95e-06148675c8e93b87212f55774223caa385859c566fa1981f
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CLXN DNAH10 DNAH9 AK8

3.58e-061546754e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CLXN DNAH10 DNAH9 AK8

3.58e-061546757556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

3.70e-061556755f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

3.70e-061556750944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 SERPINA1 CLXN ANPEP ADGRV1

4.06e-0615867535aee1c3b92169e73569331022833cb44ab7e7e8
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 CFAP300 CLXN ANPEP DNAH9

4.87e-06164675e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESYT3 SLC9A9 ANPEP PLCB2 RYR1

6.14e-06172675a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESYT3 ANPEP CGAS PLCB2 RYR1

7.25e-061786758c5e9fab7b55a654ccaabf2c4d02397399d94616
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

7.25e-06178675de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CLXN DNAH10 DNAH9 AK8

7.45e-061796755e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

7.66e-06180675adf5db5bfa9a38b1227ab0beccd8d6f3eea67ac0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 PTPN13 KIF26B SHCBP1 STAM

7.87e-06181675b7c85fbef3c06d5dc32a2a58f8d3dfabf1d79d9f
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

8.08e-061826757ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DNAH3 CLXN DNAH10 DNAH9 AK8

8.08e-06182675fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.08e-06182675975f6275777fc578eba528e50f69891c66ec44ad
ToppCell368C-Epithelial_cells-Epithelial-F_(Ciliated)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.08e-06182675f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)-|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.30e-06183675b1336eac5adbffade4cef3e0ce3de75a781ae365
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

ESYT3 RAP1GAP PTPN13 MYO6 ADGRV1

8.30e-061836758e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell367C-Epithelial_cells-Epithelial-F_(Ciliated)|367C / Donor, Lineage, Cell class and subclass (all cells)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.30e-06183675cc57dcb59c68d68a546dc108dd9e009b2aab8da5
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

8.52e-061846755daff849625f2f41d56615569c0ed59cd733b34c
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DNAH3 CLXN DNAH10 DNAH9 AK8

8.75e-0618567518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellP28-Epithelial-airway_epithelial_cell-club_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 CLXN DNAH10 DNAH9 AK8

8.98e-06186675a26811481668fa25c48a064a56c198685693ad8d
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.98e-0618667576033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellP28-Epithelial-airway_epithelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

DNAH3 CLXN DNAH10 DNAH9 AK8

8.98e-06186675df80f101954b8ec6ccdb03e702de22e70b65181f
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

8.98e-0618667585787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellCOPD-Epithelial-Ciliated|COPD / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

9.21e-06187675f0fd0792f6926f705d175f6e6fd480f12c7a3bd4
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

STARD13 ESYT3 SERPINA1 RAP1GAP STAM

9.21e-06187675030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.21e-061876759e10ed56090d82589bc457788282f664b70ace4b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDR2 SERPINA1 EXPH5 ADGRV1 MCF2L

9.21e-06187675c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.21e-06187675e61992de4f98eeea08b43213850769d923f8db48
ToppCellCiliated_cells-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.21e-06187675bc1f33f332ac939c2425f510173430ca2ba0c3ee
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 CPAMD8 PTPN13 SHCBP1 PPARG

9.21e-06187675e3095455d2f255854f339f6b05fa87852af0700f
ToppCellmulticiliated|World / shred by cell class for bronchial biopsy

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.45e-061886756833c1f0f265ef5448fa65033550ed7efc2f8d7b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.45e-0618867561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.45e-0618867534b11f72ca73153d02edcd09b38983ad1a504659
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.45e-061886752b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCelldroplet-Kidney-nan-3m-Epithelial-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP5PF RAP1GAP GCGR PKDREJ ATP5F1B

9.45e-061886756b185d0aaeea64f9ae584a9bcb9741658bb1c7bd
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

DNAH3 CLXN DNAH10 DNAH9 AK8

9.70e-06189675a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.70e-0618967568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.70e-06189675a3cd4c2da4feb9bdcd8957f3e344d095da1367b8
ToppCellMulticiliated|World / shred by cell class for nasal brushing

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.70e-0618967534b110aef839376228c5a403a6b5047a945f472b
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DNAH3 CLXN DNAH10 DNAH9 AK8

9.70e-06189675b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DNAH3 CLXN DNAH10 DNAH9 AK8

9.70e-0618967527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

9.70e-061896753e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellcellseq2-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.70e-0618967593b1026bb1ba759e5704561c9a5de14a30c08894
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDR2 SERPINA1 EXPH5 ADGRV1 MCF2L

9.95e-061906751cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.95e-061906759ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.95e-06190675833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCellcellseq2-Epithelial-Epithelial_Airway|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CFAP300 CLXN DNAH10 DNAH9

9.95e-0619067517829f4de31b3d9e4d71ba4817d18842aa699773
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 PTPN13 SHCBP1 STAM PPARG

9.95e-06190675b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.02e-051916752a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ESYT3 CPAMD8 RAP1GAP PTPN13 ADGRV1

1.02e-0519167534cc997e4e5c727495f321e6807a84aa124da486
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.02e-0519167546c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.02e-05191675995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.02e-05191675a37f20172b85566b9039254a89680e37fd503fd5
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.02e-051916752d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CLXN DNAH10 DNAH9 AK8

1.02e-05191675e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CLXN DNAH10 DNAH9 AK8

1.02e-051916759d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DNAH3 CLXN DNAH10 DNAH9 AK8

1.02e-051916751c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.05e-05192675be592e661367affced9ebe80849b466e6adb3a34
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ESYT3 RAP1GAP PTPN13 MYO6 ADGRV1

1.05e-05192675fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

1.05e-05192675eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.07e-05193675e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

1.07e-051936750e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 DNAH10 EXPH5 ADGRV1 DNAH9

1.07e-05193675ea345d34440b25f65358a53dc72831998d1c3620
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

1.07e-05193675ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.07e-051936750b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC9A9 KIF26B VWA5A ARHGAP12 PPARG

1.07e-05193675c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CPAMD8 PTPN13 MYO6 EXPH5 ADGRV1

1.07e-05193675a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.10e-051946751ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 SLC9A9 PLB1 PLCB2 RYR1

1.10e-05194675c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.10e-0519467543be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.13e-051956750e763f36786515698b593e5c93f6a56619c1242d
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

DNAH3 CLXN DNAH10 DNAH9 AK8

1.13e-0519567521dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCelldistal-Epithelial-Proximal_Ciliated|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH3 CFAP300 CLXN DNAH9 AK8

1.13e-05195675abe7998421dc59bdae35c0c2251c4a1ebef5e021
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.13e-05195675581b04220587e1d5198b1abd6965965ace7803e7
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.13e-0519567593b1559382a12cfb158aa5fac7386e38b4f87989
ToppCellNS-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.13e-0519567534e37cff4849696ca4ba5dd8fd2cf98fed8bc912
ToppCelldistal-Epithelial-Proximal_Ciliated-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DNAH3 CFAP300 CLXN DNAH9 AK8

1.13e-051956750e3f74e0877d33c11f048b9be8394596cf5c9c4c
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.13e-0519567507a6bcef6af93ed87df455dee624037cb75e011a
ToppCellCOVID-19-Epithelial-Ciliated_cells|Epithelial / Condition, Lineage and Cell class

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-05196675de7aa31354b019d7321a8ef965d59ce2e8b89276
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-0519667527b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-05196675686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-0519667567aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-05196675ca56311edc6788e032e7635fa69b1e07035202b5
ToppCellSevere_COVID-19-Epithelial-Ciliated|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

DNAH3 CFAP300 CLXN DNAH10 DNAH9

1.16e-051966751cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 SLC9A9 PLB1 PLCB2 RYR1

1.16e-05196675cbc727b55b6433a701b1a331028a49960fcee6ee
DrugBiliton

DNAH3 DNAH10 MCF2L DNAH9 SIRT1

1.31e-0741675CID000002974
Diseasepolycystic kidney disease (implicated_via_orthology)

STAM2 STAM PPARG

4.00e-0614673DOID:0080322 (implicated_via_orthology)
Diseasetransient cerebral ischemia (biomarker_via_orthology)

PTPN5 PTPN13 PPARG HTT ATP5F1B

2.96e-05157675DOID:224 (biomarker_via_orthology)
DiseaseNerve Degeneration

PTPN5 VPS54 PPARG SIRT1

3.90e-0583674C0027746
Diseasehypertrophic cardiomyopathy 10 (implicated_via_orthology)

MYL2 MYL10

5.06e-055672DOID:0110316 (implicated_via_orthology)
DiseaseDiabetes Mellitus

THBS2 PPARG SIRT1

5.29e-0532673C0011849
Diseaseglucagon measurement, glucose tolerance test

SERPINA1 MACF1

7.57e-056672EFO_0004307, EFO_0008463
DiseaseAcute Kidney Insufficiency

SERPINA1 PPARG SIRT1 ATP5F1B

8.40e-05101674C1565662
DiseaseAcute kidney injury

SERPINA1 PPARG SIRT1 ATP5F1B

8.40e-05101674C2609414
DiseaseKidney Failure, Acute

SERPINA1 PPARG SIRT1 ATP5F1B

8.40e-05101674C0022660
Diseasevisceral:gluteofemoral adipose tissue ratio measurement

SERPINA1 DNAH10 PPARG

1.48e-0445673EFO_0803319
Diseaseplatelet crit

STARD13 DNAH3 SERPINA1 KIF26A EXPH5 ADGRV1 PPARG DNAJC5B TRDMT1

2.91e-04952679EFO_0007985
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

SERPINA1 DNAH10 MACF1 PPARG HTT

3.39e-04264675EFO_0008317, EFO_0020944
DiseaseMood Disorders

SERPINA1 PPARG SIRT1 HTT

5.88e-04168674C0525045
DiseaseCongenital Fiber Type Disproportion

MYL2 RYR1

7.59e-0418672C0546264
Diseaseresponse to methotrexate, neurotoxicity

MACF1 DCT

8.47e-0419672EFO_0011057, GO_0031427
DiseasePsychoses, Drug

GCLM GRM2

1.04e-0321672C0033937
DiseaseHuntington's disease (is_implicated_in)

SIRT1 HTT

1.25e-0323672DOID:12858 (is_implicated_in)
Diseaseobesity (implicated_via_orthology)

DNAH10 PLCB2 SIRT1 ATP5F1B

1.47e-03215674DOID:9970 (implicated_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

SERPINA1 MACF1 PPARG HTT

1.65e-03222674EFO_0008317, EFO_0020943
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

DNAH10 MACF1 PPARG DCT

1.70e-03224674EFO_0004530, EFO_0008317
Diseasealkaline phosphatase measurement

SERPINA1 RAP1GAP PPP1R3B EIF2B2 MACF1 PPARG DCT AK8

2.07e-031015678EFO_0004533
Diseasepathological myopia

PPP1R3B DNAJC5B DNAH9

2.08e-03111673EFO_0004207
Diseaseresting heart rate, chronic obstructive pulmonary disease

PLB1 ADGRV1

2.12e-0330672EFO_0000341, EFO_0004351
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

SERPINA1 ANPEP STAM PPARG

2.16e-03239674EFO_0010934
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

SERPINA1 MACF1 PPARG HTT

2.16e-03239674EFO_0008317, EFO_0020945

Protein segments in the cluster

PeptideGeneStartEntry
LEPLFDETFEFFVPM

ESYT3

816

A0FGR9
DIPFAMFAPKNLELE

ATG13

391

O75143
VLFVKFSMPSVPDFE

COPS3

61

Q9UNS2
PEVKFNKPFVFLMIE

SERPINA1

386

P01009
FARTVPPDFFQAKAM

GRM2

181

Q14416
PPDFFQAKAMAEILR

GRM2

186

Q14416
MPPDLTAFAKQFDIQ

GCLM

196

P48507
MVPFNDDPFGVFILD

ADGRV1

1231

Q8WXG9
FPCFDEPAMKAEFNI

ANPEP

221

P15144
MEKDVDFPVFLQPTN

DNAJC5B

166

Q9UF47
QMVPKFCFPFDVERE

DENND1C

46

Q8IV53
SAPNEFDVMFKLEVP

CGAS

221

Q8N884
KQFAPIHAEAPEFME

ATP5F1B

161

P06576
DPFLLQAEFFEIPMN

PTPN5

296

P54829
QAEFFEIPMNFVDPK

PTPN5

301

P54829
SKEEVDQMFAAFPPD

MYL2

131

P10916
QVPPKMFAFDAVFPQ

KIF26B

501

Q2KJY2
LIQPFFEKEMAVPDS

AK8

316

Q96MA6
PQVPSAQVMDFLFEK

GCGR

21

P47871
FMPPNFPEFAERIEA

MACF1

136

O94854
MTKVPPAFDFSFLND

EXPH5

1

Q8NEV8
VPKMFAFDAVFPQDS

KIF26A

426

Q9ULI4
SEEEVKQMFAAFPPD

MYL10

191

Q9BUA6
KMFFRELPEPLFTFN

ARHGAP12

731

Q8IWW6
DMNTFPTFKFEDPKF

ATP5PF

86

P18859
DFVMAFFKDPNVIPN

CFAP300

61

Q9BRQ4
DFFPPQDIMNKVIGE

HTT

2986

P42858
APIMFGIKTEPEFFE

GNE

26

Q9Y223
NDFKEPYQEMKFFIP

DNAH3

471

Q8TD57
VPFKEPSQSLLEEMF

CDR2

281

Q01850
TFKPFFVDFMLPALI

CPAMD8

801

Q8IZJ3
PAFSEIPDKEFQNVM

MCF2L

101

O15068
FYEPFMDEPIAIPNK

CASQ2

216

O14958
DFNIPKIVTDDMPIF

DNAH9

2076

Q9NYC9
MFKLSPQFPNEEDSF

EIF2B2

271

P49770
LRDMNLPKFVFEDVP

DNAH10

2036

Q8IVF4
KYVQPPMISFEAIFE

DNAH10

3856

Q8IVF4
PCFFQDISMEIPQEF

SCAMP3

146

O14828
LVFDVPILNEFAKMP

RYR1

2626

P21817
VKVFSEFDDPLDMPF

PPP1R3B

76

Q86XI6
RNFFGPEFVKMTIEP

PTPN13

536

Q12923
VADMVKQFFRDLPEP

STARD13

731

Q9Y3M8
FQAPGQVLMEFPKIE

TRDMT1

176

O14717
QMFVFFPEEPKVGIK

POLR2E

71

P19388
KMTFDPEIFFNVLLP

SLC9A9

126

Q8IVB4
KNVDFREFMVAFPDP

TMEM151B

276

Q8IW70
DVMDVFIPKPFRAFA

TARDBP

216

Q13148
EPEFFIDMLYGQPEK

PKDREJ

2216

Q9NTG1
KPFGDFMEPKFEFAV

PPARG

386

P37231
VFQDENTPFVPDMIA

RAP1GAP

296

P47736
DEPLAIMKPEIVFFG

SIRT1

401

Q96EB6
IMKPEIVFFGENLPE

SIRT1

406

Q96EB6
PDADQMTKIPFFDDV

SCYL2

316

Q6P3W7
LQSFMPEGKTFFPEI

SHCBP1

56

Q8NEM2
VVQPFFENVDMPKTS

PLB1

626

Q6P1J6
NFRMDFPFDLKELPA

CLCN1

336

P35523
PKSQMEFEAQVFKDP

CLXN

191

Q9HAE3
EFNPNFVARMIPKVE

TRMT112

36

Q9UI30
ENEIFPSPTEFFMPI

SPATA7

481

Q9P0W8
MPLFATNPFDQDVEK

STAM

1

Q92783
MPLFTANPFEQDVEK

STAM2

1

O75886
NEEKVPLEAFFVFPM

VWA5A

41

O00534
NMVPFFPPVTNEELF

DCT

431

P40126
EPFVFEKILMPELAS

PLCB2

736

Q00722
VPFREMKPVIFLDVF

PRKDC

896

P78527
FDADRPPQLKNMEVF

ZNF862

936

O60290
ETDFRNFQMVPLDPK

THBS2

956

P35442
NTDEPPMVFKAQLFA

USP14

21

P54578
QVPKIFMKPDFALDD

VPS54

161

Q9P1Q0
DFDAPIEEFMSQPEK

NLRP13

291

Q86W25
VFFRPGKFAEFDQIM

MYO6

756

Q9UM54